Journal of neurophysiology最新文献_第3页

Inhibitory effects of dopamine agonists on pain-responsive neurons in the central nucleus of the amygdala. 多巴胺激动剂对杏仁核中央核疼痛反应神经元的抑制作用。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00135.2025

Robert J Heuermann, Robert W Gereau

{"title":"Inhibitory effects of dopamine agonists on pain-responsive neurons in the central nucleus of the amygdala.","authors":"Robert J Heuermann, Robert W Gereau","doi":"10.1152/jn.00135.2025","DOIUrl":"10.1152/jn.00135.2025","url":null,"abstract":"The central nucleus of the amygdala (CeA) is a heterogenous region of primarily GABAergic neurons that contributes to numerous behaviors, including fear learning, feeding, reward, and pain. Dopaminergic inputs to the CeA have been shown to regulate many of these behaviors, but how dopamine exerts these effects at the cellular level has not been well characterized. We used the Targeted Recombination in Active Populations (TRAP) mouse line to fluorescently label pain-responsive CeA neurons, and then targeted these cells for patch-clamp recordings in acute slices to test the effects of dopamine agonists. The D1 agonist SKF-38393 and D2 agonist quinpirole both had inhibitory effects, reducing the input resistance and evoked firing and increasing rheobase of labeled CeA neurons. Both agents also inhibited the NMDA component of excitatory postsynaptic currents (EPSCs) evoked by basolateral amygdala (BLA) stimulation, but did not affect the AMPA component. D1 activation, but not D2, also had a possible presynaptic effect, increasing the frequency of spontaneous EPSCs. These results provide new insights into how dopamine regulates activity within pain-responsive CeA networks.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-specific generalization in walking adaptation: the role of training speed. 行走适应的年龄泛化：训练速度的作用。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00225.2025

Cris Rossi

引用次数: 0

Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular end organ electrical potentials, and increases sensory hypersensitivities. 全身降钙素基因相关肽（CGRP）改变听觉和前庭末端器官电位，增加感觉超敏反应。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00226.2024

Shafaqat M Rahman, Stefanie Faucher, Raajan Jonnala, Joseph C Holt, Choongheon Lee, Anne E Luebke

{"title":"Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular end organ electrical potentials, and increases sensory hypersensitivities.","authors":"Shafaqat M Rahman, Stefanie Faucher, Raajan Jonnala, Joseph C Holt, Choongheon Lee, Anne E Luebke","doi":"10.1152/jn.00226.2024","DOIUrl":"https://doi.org/10.1152/jn.00226.2024","url":null,"abstract":"Migraine is a severe and chronic neurological disorder that affects ~18% of people worldwide, the majority being female (3:1). It is characterized by recurrent, debilitating headaches and heightened sensory sensitivities. People with migraine may develop vestibular migraine (VM), characterized by a heightened motion sensitivity and preponderance for spontaneous vertigo attacks and balance problems such as postural instability. Calcitonin gene-related peptide (CGRP) is implicated in migraine and is believed to act on brain meninges or in subcortical central nervous system (CNS) structures, and CGRP-based antagonists have shown efficacy for migraine treatment. CGRP also signals at efferent synapses of the cochlea and vestibular end organs, but it is unclear if exogenous CGRP can modulate inner ear function at the end organ level and cause heightened behavioral responses consistent with VM. We tested if intraperitoneally (IP) delivered CGRP to wildtype mice can modulate end organ potentials to sound [via auditory brainstem responses (ABRs)] and jerk stimuli [via vestibular sensory evoked potentials (VsEPs)]. We also assessed behavioral measures of phonophobia [acoustic startle reflex (ASR)] and static imbalance [postural sway-center of pressure (CoP)] after IP CGRP, and observed female mice exhibited heightened sensitivities to IP CGRP in all assays. Male mice showed similar auditory sensitivity and end organ effects to CGRP, but systemic CGRP did not modify male postural sway as it did in females. In conclusion, we show that intraperitoneally delivered CGRP affects ABRs and VsEPs and elicits behaviors suggestive of auditory hypersensitivity and postural instability in mice related to the phonophobia and postural instability seen in VM patients.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct and Complementary Roles of Corticospinal and Corticoreticulospinal Pathways in Motor Behaviors Post-Stroke. 脑卒中后运动行为中脊髓皮质和脊髓皮质网通路的独特和互补作用。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00068.2025

Christopher M Patrick

引用次数: 0

EEG characteristics of central nervous system graft-versus-host disease. 中枢神经系统移植物抗宿主病的脑电图特征。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00142.2025

Nicolas Lambert, Majdouline El Moussaoui, Jan Brijs, Paul Chauvet, Jonathan D Santoro, Sara Gil-Perotín, Sophie Servais, Evelyne Willems, Frédéric Baron, Yves Beguin, Julie Truong, Pierre Maquet, Olivier Bodart

引用次数: 0

Locomotor CPG of mammals: the role of pacemaker and network mechanisms. 哺乳动物运动CPG：起搏器的作用及网络机制。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-27 DOI: 10.1152/jn.00208.2025

Yuri I Arshavsky

引用次数: 0

Simulations reveal that beta burst detection may inappropriately characterize the beta band. 模拟结果表明，β突发探测可能不恰当地表征了β波段。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-23 DOI: 10.1152/jn.00125.2024

Zachary D Langford, Charles R E Wilson

{"title":"Simulations reveal that beta burst detection may inappropriately characterize the beta band.","authors":"Zachary D Langford, Charles R E Wilson","doi":"10.1152/jn.00125.2024","DOIUrl":"https://doi.org/10.1152/jn.00125.2024","url":null,"abstract":"In neurophysiological research, the traditional view of beta band activity as sustained oscillations is being reinterpreted as transient bursts. Bursts are characterized by a distinct wavelet shape, high amplitude, and, most importantly, brief temporal occurrence. The primary method for their detection relies on a threshold-based analysis of spectral power, and this presents two fundamental issues. First, the threshold selection is effectively arbitrary, being influenced by both temporally proximal and distal factors in the signal. Second, the method necessarily detects temporal events, as such it is susceptible to misidentifying sustained signals as transient bursts. To address these issues, this study systematically explores burst detection through simulations, shedding light on the method's robustness across various scenarios. Although the method is effective in detecting transients in numerous cases, it can be overly sensitive, leading to spurious detections. Moreover, when applied to simulations featuring exclusively sustained events, the method frequently yields events exhibiting characteristics consistent with a transient burst interpretation. By simulating an average difference in power between experimental conditions, we illustrate how apparent burst rate differences between conditions can emerge even in the absence of actual burst rate disparities, and even in the absence of bursts. This capacity to produce misleading outcomes challenges the reinterpretation of sustained beta oscillations as transient bursts and prompts a critical reassessment of the existing literature.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models. 在基于电导的神经元模型中，高去极化基线偏移的机制和意义。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-19 DOI: 10.1152/jn.00617.2024

Anal Kumar, Anzal K Shahul, Upinder Singh Bhalla

引用次数: 0

Indecision under time pressure arises from suboptimal switching behaviour. 时间压力下的优柔寡断源于次优切换行为。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-17 DOI: 10.1152/jn.00563.2024

Seth R Sullivan, Rakshith Lokesh, Jan A Calalo, Truc Ngo, John H Buggeln, Adam M Roth, Christopher Peters, Isaac Kurtzer, Michael J Carter, Joshua G A Cashaback

{"title":"Indecision under time pressure arises from suboptimal switching behaviour.","authors":"Seth R Sullivan, Rakshith Lokesh, Jan A Calalo, Truc Ngo, John H Buggeln, Adam M Roth, Christopher Peters, Isaac Kurtzer, Michael J Carter, Joshua G A Cashaback","doi":"10.1152/jn.00563.2024","DOIUrl":"https://doi.org/10.1152/jn.00563.2024","url":null,"abstract":"Indecisive behaviour can be catastrophic, leading to car crashes or stock market losses. Despite fruitful efforts across several decades to understand decision-making, there has been little research on what leads to indecision. Here we examined how indecisions arise under high-pressure deadlines. In our first experiment participants attempted to select a target by either reacting to a stimulus or guessing, when acting under a high pressure time constraint. We found that participants were suboptimal, displaying a below chance win percentage due to an excessive number of indecisions. Computational modelling suggested that participants were excessively indecisive because they failed to account for a time delay and temporal uncertainty when switching from reacting to guessing, a phenomenon previously unreported in the literature. In a follow-up experiment we pro- vide direct evidence for a functionally relevant time delay and temporal uncertainty when switching from reacting to guessing. Collectively, our results indicate that participants failed to account for a time delay and temporal uncertainty associated with switching from reacting to guessing, leading to suboptimal and indecisive behaviour.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex. 腹侧纹状体优先与突出网络相关，包括背外侧前额皮质区域。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-05-16 DOI: 10.1152/jn.00477.2024

Heather L Kosakowski, Jingnan Du, Vaibhav Tripathi, Mark C Eldaief, Randy L Buckner

{"title":"Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex.","authors":"Heather L Kosakowski, Jingnan Du, Vaibhav Tripathi, Mark C Eldaief, Randy L Buckner","doi":"10.1152/jn.00477.2024","DOIUrl":"10.1152/jn.00477.2024","url":null,"abstract":"The ventral striatum (VS) receives input from the cerebral cortex and is modulated by midbrain dopaminergic projections in support of processing reward and motivation. Here we explored the organization of cortical regions linked to the human VS using within-individual functional connectivity MRI in intensively scanned participants. In two initial participants (scanned 31 sessions each), seed regions in the VS were preferentially correlated with distributed cortical regions that are part of the Salience network. The VS seed regions recapitulated Salience network topography and replicated in each individual including anterior and posterior midline regions, anterior insula, and dorsolateral prefrontal cortex (DLPFC). The topography was distinct from adjacent striatal seed regions and from cortical networks associated with domain-flexible cognitive control. Unbiased comprehensive analyses of the full striatum confirmed that the VS is coupled to the Salience network while also revealing the established, spatially separated cognitive zones of the caudate and motor zones of the putamen. VS correlation with the Salience network including DLPFC was observed in 15 additional participants (scanned 8 or more times each) indicating it is a robust and generalizable finding. These results suggest that the VS contributes to a cortico-basal ganglia loop that is part of the Salience network and raise the possibility that the DLPFC may be an effective neuromodulatory target for neuropsychiatric disorders of reward and motivation because of its preferential coupling to the VS.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0