Journal of neurophysiology最新文献_第3页

Maximal human motor unit firing rates decline in response to non-volitional induced torque loss: further evidence for peripheral feedback inhibition. 最大人类运动单位放电率下降响应非意志诱导扭矩损失：进一步的证据外周反馈抑制。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-27 DOI: 10.1152/jn.00173.2025

Alexander M Zero, Jacob Fanous, Charles L Rice

{"title":"Maximal human motor unit firing rates decline in response to non-volitional induced torque loss: further evidence for peripheral feedback inhibition.","authors":"Alexander M Zero, Jacob Fanous, Charles L Rice","doi":"10.1152/jn.00173.2025","DOIUrl":"https://doi.org/10.1152/jn.00173.2025","url":null,"abstract":"The purpose was to assess whether voluntary descending drive is obligatory to reduce maximal motor unit (MU) firing rates following high-intensity muscle fatiguing activation. Maximal MU firing rates were compared following a sustained 60s maximal voluntary contraction (MVC) and separately following 60s of supramaximal tetanic peripheral nerve stimulation (decaying rate 40-20 Hz) at high torque levels (initial torque ~81% MVC). In ten participants grouped firing rates of 2290 MUs from the tibialis anterior were recorded with intramuscular tungsten microelectrodes. Baseline MU firing rates during dorsiflexion MVC were 40 ±11.5 Hz. Immediately (~2s) after both tasks, MVC torque (P = 0.08) and maximal MU firing rates (P = 0.14) were depressed equally (all ~30%, P<0.001). After 10-min of rest, MVC torque recovered to baseline values following both tasks (P ≥ 0.17) and maximal firing rates recovered similarly (P = 0.12) in both tasks throughout recovery and returned to ~95% of baseline values (P ≤ 0.02) by 10-min. Furthermore, there were negative correlations (all P ≤0.003) between MU firing rates with both electrically evoked doublet half-relaxation time (r=-0.48, r=-0.38) and contraction time (r=-0.39, r=-0.38) during recovery from both fatiguing tasks. These results indicate that factors related to voluntary activation of descending pathways are not directly responsible for the frequently observed reduction of maximal MU firing rates after sustained high-intensity activation. Rather, with non-volitional induced contractile failure, firing rates declined similar to the voluntary task, providing novel support for peripheral feedback mechanisms as the primary regulator of firing rate during this fatiguing task.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human motor unit discharge patterns reveal differences in neuromodulatory and inhibitory drive to motoneurons across contraction levels. 人类运动单元放电模式揭示了运动神经元在收缩水平上的神经调节和抑制性驱动的差异。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-27 DOI: 10.1152/jn.00249.2025

Jakob Škarabot, James A Beauchamp, Gregory E P Pearcey

{"title":"Human motor unit discharge patterns reveal differences in neuromodulatory and inhibitory drive to motoneurons across contraction levels.","authors":"Jakob Škarabot, James A Beauchamp, Gregory E P Pearcey","doi":"10.1152/jn.00249.2025","DOIUrl":"https://doi.org/10.1152/jn.00249.2025","url":null,"abstract":"All motor commands converge onto motor units (MUs), which transduce the signals into mechanical actions of muscle fibres. This process is highly non-linear due to combinations of ionotropic (excitatory/inhibitory) and metabotropic (neuromodulatory) inputs. Neuromodulatory inputs facilitate dendritic persistent inward currents, which introduce non-linearities in MU discharge patterns and provide insights into the structure of motor commands. Here, we investigated the relative contribution of neuromodulation and the pattern of inhibition to modulate human MU discharge patterns with contraction forces up to 70% maximum. Leveraging MU discharge patterns identified from three human muscles (tibialis anterior - TA, and vastus lateralis and medialis), we show that with increased contraction force, the onset-offset discharge rate hysteresis (ΔF) increased whilst ascending MU discharge patterns become more linear, with lower slopes. In a follow-up experiment, we demonstrated that the observations of increased ΔF and more linear ascending MU discharge patterns with greater contraction force are maintained even when accounting for contraction duration and rate of force increase. We then reverse-engineered TA MU discharge patterns using highly realistic in silico motoneuron pools to substantiate the inferred physiological mechanisms from human recordings. We demonstrate a sharply restricted solution space, whereby the contraction force-induced changes in experimentally obtained MU discharge patterns can only be recreated with increased neuromodulation and a more reciprocal (i.e. push-pull) inhibitory pattern. In summary, our experimental and computational data suggest that neuromodulation and inhibitory patterns are uniquely shaped to generate discharge patterns that support force increases across a large proportion of the motor pool's recruitment range.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive spatiotemporal spinal neuromodulation targeting dorsal roots improves paretic leg motor control during walking in persons with stroke. 针对背根的非侵入性时空脊髓神经调节可改善中风患者行走时的瘫腿运动控制。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-27 DOI: 10.1152/jn.00316.2025

Hyosok Lim, Shijun Yan, Iram Hameeduddin, Weena Dee, Velarie Pech, William Z Rymer, Ming Wu

{"title":"Non-invasive spatiotemporal spinal neuromodulation targeting dorsal roots improves paretic leg motor control during walking in persons with stroke.","authors":"Hyosok Lim, Shijun Yan, Iram Hameeduddin, Weena Dee, Velarie Pech, William Z Rymer, Ming Wu","doi":"10.1152/jn.00316.2025","DOIUrl":"https://doi.org/10.1152/jn.00316.2025","url":null,"abstract":"Individuals post-stroke demonstrate impaired motor control and muscle weakness in the paretic leg interfering their mobility. We aimed to determine whether applying spatiotemporally controlled transcutaneous spinal cord stimulation (tSCS), when combined with constraint force induced forced use (CIFU), enhances paretic leg motor control during walking in individuals post-stroke. Thirteen individuals with stroke (age: 64.2 ± 7.1 years old; time post stroke: 14.1 ± 6.1 years) were tested in a crossover design under two conditions: active vs sham tSCS during CIFU treadmill walking (tSCS+CIFU vs sham+CIFU). In both conditions, CIFU treadmill walking was performed with constraint force applied to the non-paretic leg during swing phase of gait. For the active condition, tSCS was delivered at L4 during the swing phase (80 Hz) and at S1 during the stance phase (30 Hz) of the paretic leg, filled with a carrier frequency of 9.5 kHz. Spatiotemporal gait parameters, muscle activity, and propulsive force were assessed. Participants showed greater increases in paretic step length and step height in the tSCS+CIFU condition compared to the sham+CIFU condition, while showed prolonged paretic stance time in both conditions. The tSCS+CIFU condition also showed significantly less foot path variability of the paretic leg compared to sham+CIFU. Muscle synergy analysis revealed increased muscle weightings in plantarflexion, dorsiflexion, and hip/knee extension synergies of the paretic leg in both conditions. Propulsive force of the paretic leg showed no change in both conditions. In conclusion, applying spatiotemporally controlled tSCS during CIFU treadmill walking may enhance paretic leg motor control in individuals post-stroke.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating Activity-Dependence of Exogenous Proctolin's Ability to Modulate Muscle Contraction in Drosophila. 外源性Proctolin调节果蝇肌肉收缩能力的活性依赖性研究。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-27 DOI: 10.1152/jn.00549.2024

JaeHwan Jung, Kerstyn L Lutz, Katie-Christina Dreager-Tougas, A Joffre Mercier

{"title":"Investigating Activity-Dependence of Exogenous Proctolin's Ability to Modulate Muscle Contraction in Drosophila.","authors":"JaeHwan Jung, Kerstyn L Lutz, Katie-Christina Dreager-Tougas, A Joffre Mercier","doi":"10.1152/jn.00549.2024","DOIUrl":"https://doi.org/10.1152/jn.00549.2024","url":null,"abstract":"Proctolin, an arthropod neuropeptide, is present in synaptic terminals innervating body wall muscles of Drosophila larvae. It acts as a cotransmitter with the excitatory neurotransmitter, L-glutamate (Glu). Previous work showed that exogenous proctolin increases nerve-evoked contractions in larval muscles, and increasing neural activity decreases threshold and EC50 values for the effect. We investigated the possibility that the decrease in threshold is related to an increase in Glu release as neural activity increases. We directly applied exogenous Glu to muscles to mimic Glu release in the absence of nerve activity to avoid synaptic release of proctolin and other cotransmitters. Applying Glu to larval muscles elicited contraction, and increasing Glu concentration increased contraction amplitude in a dose-dependent manner. Increasing Glu from a low to a moderate concentration decreased the threshold for exogenous proctolin to enhance contraction. At a higher Glu concentration, however, the threshold increased to the same level observed at the lower concentration. These results do not agree with predicted effects of exogenous proctolin. Applying proctolin also increased caffeine-induced contractions, but increasing caffeine concentration did not alter the threshold for this effect. Exogenous proctolin did not alter Glu-induced depolarization. These results suggest that the activity-dependent increase in exogenous proctolin's effectiveness is not due solely to increased Glu release, increased muscle depolarization or increases in cytosolic Ca2+ in muscle. Exogenous proctolin and Glu both induced contraction. Their effects were supra-additive, but proctolin did not decrease the threshold for Glu to elicit contractions. Thus, the two substances do not exhibit synergism.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Speed-dependent locomotor adjustments following staggered thoracic lateral hemisections in adult cats. 成年猫交错胸外侧半切后的速度依赖运动调节。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-23 DOI: 10.1152/jn.00331.2025

Sirine Yassine, Johannie Audet, Charly Lecomte, Stephen Mari, Angèle N Merlet, Jonathan Harnie, Ilya A Rybak, Boris I Prilutsky, Alain Frigon

{"title":"Speed-dependent locomotor adjustments following staggered thoracic lateral hemisections in adult cats.","authors":"Sirine Yassine, Johannie Audet, Charly Lecomte, Stephen Mari, Angèle N Merlet, Jonathan Harnie, Ilya A Rybak, Boris I Prilutsky, Alain Frigon","doi":"10.1152/jn.00331.2025","DOIUrl":"https://doi.org/10.1152/jn.00331.2025","url":null,"abstract":"Animals adjust their locomotor pattern to increased speed demands by decreasing stance/extensor phase duration while the swing/flexor phase remains relatively unchanged, which we refer to here as 'stance/extensor dominance'. The control of locomotor speed involves dynamic interactions between spinal circuits, supraspinal drive and somatosensory feedback. While complete spinal cord injuries abolish brain-spinal cord interactions, incomplete lesions, such as lateral hemisections, preserve some connectivity between brain and spinal circuits. In this study, we investigated adjustments in the locomotor pattern at different treadmill speeds before and after staggered lateral thoracic hemisections performed on opposite sides of the spinal cord (first at right T5-T6 and then at left T10-T11). We collected kinematic and electromyographic data during treadmill locomotion from 0.4 to 0.8 m/s before and eight weeks after each spinal lesion in eight adult cats. Our main results show left-right asymmetries in hindlimb phase durations after each lesion, with prolonged swing on the ipsilesional side and prolonged stance on the contralesional side across speeds. Hindlimb stance dominance was also weakened on the side of each lesion, first on the right and then on the left after the first and second hemisections, respectively. In contrast to phase durations, hindlimb stride lengths remained symmetric after both injuries across speeds. Using our recent computational models (1,2) and experimental data of the present study, we provide predictions of altered interactions between supraspinal drive and somatosensory feedback onto flexor and extensor half centers to explain left-right changes in hindlimb phase durations across speeds after staggered lateral thoracic hemisections.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensorimotor Integration During Grasping Is Mediated by Distinct M1 Circuits. 抓握过程中感觉运动整合由不同的M1回路介导。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-22 DOI: 10.1152/jn.00189.2025

Katia Botta, Elisa Dolfini, Andrea Casarotto, Giacomo Koch, Alessandro D'Ausilio, Luciano Fadiga

{"title":"Sensorimotor Integration During Grasping Is Mediated by Distinct M1 Circuits.","authors":"Katia Botta, Elisa Dolfini, Andrea Casarotto, Giacomo Koch, Alessandro D'Ausilio, Luciano Fadiga","doi":"10.1152/jn.00189.2025","DOIUrl":"https://doi.org/10.1152/jn.00189.2025","url":null,"abstract":"Motor control relies on the dynamic interplay between excitatory and inhibitory influences shaping sensorimotor integration during hand movements. In this study, we investigated short-latency afferent inhibition (SAI)-a neurophysiological marker of sensorimotor integration-during different isometric grasping behaviours (precision vs. power grip). We applied transcranial magnetic stimulation (TMS) with different coil orientations [antero-posterior (AP) vs. postero-anterior (PA)] to engage distinct neuronal populations within the primary motor cortex (M1). We found increased SAI in the AP direction during grasp execution and enhanced corticospinal excitability for precision grip when tested with AP stimulation. These findings provide evidence that distinct cortical circuits within M1 are differentially engaged during different hand configurations. Notably, we observe no grip-specific modulation of SAI, which may reflect less topographically precise distribution of thalamocortical afferents-along with their lower temporal resolution, potentially shaped by cholinergic modulation. In addition, the execution of a grasping action engages a complex parieto-frontal network, with the ventral premotor cortex (PMv) playing a crucial role in motor planning by transforming object-related visual properties into motor plans. PMv may play a more prominent role than primary somatosensory cortex in distinguishing between precision and power grips, as recent findings suggest a preferential involvement of superficial M1 populations-targeted by PMv input-during precision grip execution. Future studies should investigate SAI dynamics across different phases (i.e. preparation vs. execution) of naturalistic prehension.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural circuit architecture and directional information processing of airflow stimuli in the cricket brain. 蟋蟀脑内气流刺激的神经回路结构及方向信息处理。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-18 DOI: 10.1152/jn.00254.2025

Hikaru Chida, Hisashi Shidara, Hiroto Ogawa

{"title":"Neural circuit architecture and directional information processing of airflow stimuli in the cricket brain.","authors":"Hikaru Chida, Hisashi Shidara, Hiroto Ogawa","doi":"10.1152/jn.00254.2025","DOIUrl":"https://doi.org/10.1152/jn.00254.2025","url":null,"abstract":"Animals process spatial information of external stimuli and exhibit goal-directed behaviors based on this information. However, the neural circuits that link sensory inputs to motor outputs for directional control remain poorly understood. To clarify the entire picture of sensory-motor association underlying the goal-directed behavior, we examined the central nervous system of crickets, which exhibit wind-elicited escape behaviors. Crickets exhibit directed escape movements in response to a short air puff, moving precisely in the opposite direction to the stimulus. Directional control in escape behavior requires descending signals from the brain to the thoracic ganglia that include a motor center for the legs in insects. To clarify the brain neural circuit involved in directed escape behavior, we examined the firing activities of brain interneurons evoked by airflow stimuli applied from various directions by using intracellular recordings. Based on the morphology of the recorded cells, the wind-sensitive interneurons were classified into three types: ascending neurons (ANs, n=27), local interneurons (LIs, n=42), and descending neurons (DNs, n=23). The ANs showed short-latency responses and directional preference toward the side ipsilateral to their ascending axon. LIs exhibited morphological diversity and variable directional tuning. DNs responded with longer latencies and displayed diverse directional preferences. Several DNs had dendritic arborizations in the lateral accessory lobe and showed strong directional selectivity. This study reveals the morphologies and response properties of brain interneurons that link mechanosensory processing to directional motor output, thereby contributing to a deeper understanding of the neural basis underlying goal-directed behaviors.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroscience of Human Ventral Lateral (VL) Thalamic Nucleus Related to Movement and Movement Disorders. 与运动和运动障碍相关的人类丘脑腹侧核神经科学。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-17 DOI: 10.1152/jn.00038.2025

Frederick A Lenz, Timothy J Meeker, Mark I Saffer, Kenichi Oishi

{"title":"Neuroscience of Human Ventral Lateral (VL) Thalamic Nucleus Related to Movement and Movement Disorders.","authors":"Frederick A Lenz, Timothy J Meeker, Mark I Saffer, Kenichi Oishi","doi":"10.1152/jn.00038.2025","DOIUrl":"10.1152/jn.00038.2025","url":null,"abstract":"The ventral lateral nucleus (VL) in the human ventral group exhibits activity associated with active and passive limb movements, as well as pathological movements found in patients with movement disorders. This group includes the anterior (VLa) and posterior (VLp) nuclei, which receive excitatory inputs from the deep cerebellar nuclei and inhibitory inputs from the internal segment of the globus pallidus (GPi). These nuclei primarily project to the primary and supplementary motor cortices. Despite differences in input sources, neurons in VLa and VLp often show similar activity patterns during active movements. In contrast, neurons in the cerebellar receiving nucleus respond more frequently during active movements, and microstimulation of these regions induces peripheral movements in monkeys, presumably due to their connections with the motor cortices. Neuronal activity in patients with movement disorders often mirrors the frequency of EMG activity during disordered movements, with a cross-correlation observed between neuronal firing and EMG signals. A long history of research demonstrates that stereotactic ablation of the VL nucleus can lead to sustained improvements in some movement disorders, similar to the effects achieved through high-frequency stimulation of the VL nucleus through implanted deep brain stimulation (DBS) devices.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of responses to gradual and abrupt visuo-proprioceptive cue conflict with and without feedback. 有反馈和无反馈时，对逐渐和突然的视觉本体感觉提示冲突的反应时间。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-15 DOI: 10.1152/jn.00493.2024

Reshma Babu, Roma K Matharu, Chelsea W Lo, Hannah J Block

{"title":"Timing of responses to gradual and abrupt visuo-proprioceptive cue conflict with and without feedback.","authors":"Reshma Babu, Roma K Matharu, Chelsea W Lo, Hannah J Block","doi":"10.1152/jn.00493.2024","DOIUrl":"10.1152/jn.00493.2024","url":null,"abstract":"When people observe conflicting visual and proprioceptive cues about their static hand position, visuo-proprioceptive recalibration results: The proprioceptive estimate of hand position shifts toward the visual estimate, and vice versa. Recalibration also occurs during gradual or abrupt visuomotor adaptation, in response to both cue conflict and sensory prediction errors experienced as the hand reaches to a target. Here we asked whether creating a cue conflict gradually vs. abruptly, or providing error feedback, affects recalibration in a static hand. We examined participants' responses to a 70 mm conflict imposed by shifting the visual cue forward from the proprioceptive cue (static left hand). Participants pointed with their unseen right hand to indicate perceived bimodal and unimodal cue positions. Conflict was introduced gradually (groups 1 and 2) or abruptly (groups 3 and 4), with performance feedback present (groups 2 and 4) or absent (groups 1 and 3). For abrupt groups, most behavioral change occurred immediately after the conflict began. No-feedback groups (1 and 3) showed comparable magnitudes of overall recalibration, indicating that abrupt and gradual conflicts result in similar recalibration but with different timings. Proprioceptive recalibration occurred in the presence of error feedback (groups 2 and 4); however, recalibration was not increased by the addition of error-based processes. Control groups confirmed accurate performance on the pointing task despite the visual cue shift. These findings highlight the distinct timing of recalibration mechanisms for gradual versus abrupt cue conflicts and potential smaller contribution of error mechanisms for a cue conflict in a stationary hand.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of simple motor exercise on motor adaption in complex dynamic tasks: Exploring Age-related Variations. 简单运动训练对复杂动态任务中运动适应的影响：探索年龄相关变化。

IF 2.1 3区医学

Journal of neurophysiology Pub Date : 2025-09-15 DOI: 10.1152/jn.00194.2025

Kimia Kiani, Qiushi Fu

{"title":"Effect of simple motor exercise on motor adaption in complex dynamic tasks: Exploring Age-related Variations.","authors":"Kimia Kiani, Qiushi Fu","doi":"10.1152/jn.00194.2025","DOIUrl":"https://doi.org/10.1152/jn.00194.2025","url":null,"abstract":"Dexterous manual actions rely on the integration of precise sensorimotor control and adaptive learning. However, it remains unclear how repetition of simple motor tasks influences subsequent adaptation to force perturbations in a dynamic manipulation task. This study examined whether different types of motor repetition, force-based or movement-based, affect the adaptation process in young and older adults. Sixty right-handed participants (30 young, 30 older) performed a dynamic manipulation task using a robotic interface, where they had to counteract perturbation torques during a handle-lifting movement. Before the perturbation trials, participants engaged in either force repetition, which required producing discrete isometric torque pulses, or movement repetition, which involved continuous wrist rotations. We found that young adults who performed force repetition exhibited enhanced adaptation in the dominant hand, while movement repetition did not yield the same benefit. However, older adults showed no significant modulation of adaptation based on repetition type. Additionally, across all participants, adaptation performance differed between supination and pronation directions, with greater accuracy observed in the supination condition. This asymmetry was more pronounced in young adults and in the non-dominant hand. These findings suggest that the benefits of force repetition for predictive motor control may depend on both age and limb dominance, with implications for motor training and rehabilitation strategies.","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0