{"title":"Motion Artifacts in SPECT Myocardial Perfusion Imaging.","authors":"Sara G Johnson","doi":"10.2967/jnmt.125.269853","DOIUrl":"10.2967/jnmt.125.269853","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"138-139"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wesley Ng, Kunthi Pathmaraj, Natalia Kovaleva, Aurora Poon, Peter Kench, Steven Meikle, Andrew Scott, Raef Boktor
{"title":"Single- Versus Dual-Time-Point Imaging for Transthyretin Cardiac Amyloid Using <sup>99m</sup>Tc-Pyrophosphate.","authors":"Wesley Ng, Kunthi Pathmaraj, Natalia Kovaleva, Aurora Poon, Peter Kench, Steven Meikle, Andrew Scott, Raef Boktor","doi":"10.2967/jnmt.124.269395","DOIUrl":"10.2967/jnmt.124.269395","url":null,"abstract":"<p><p>Nuclear medicine scintigraphy using <sup>99m</sup>Tc-pyrophosphate has proven valuable in the diagnosis of cardiac transthyretin amyloidosis in recent years. However, there is still confusion over the optimal imaging time points. The American Society of Nuclear Cardiology has recommended different imaging time points over the last decade. We aimed to determine whether single- or dual-time-point imaging is required for reporting purposes and which time point would be the most appropriate if a single time point was to be considered. <b>Methods:</b> Cardiac amyloid scans using <sup>99m</sup>Tc-pyrophosphate acquired from 2017 to 2023 were retrieved from our Picture Archiving and Communications System. Scans with static views and SPECT/CT images of the chest for both imaging time points, at 1 h (early) and 3 h (delayed) after injection, were included. Each study was independently read by 3 nuclear medicine physicians. Original clinical reports using both imaging time points were used as a reference to calculate the accuracy of a single time point. <b>Results:</b> In total, 70 patients were included in this study. Reports of cardiac amyloid studies using any single-time-point imaging were highly sensitive, accurate, and specific. There was agreement among all readers. Of the 140 datasets reported by each reader, 4 scans were classified as equivocal, requiring more imaging for confident reporting. <b>Conclusion:</b> Single-time-point imaging showed an accuracy comparable to the dual-time-point imaging in diagnosing cardiac transthyretin amyloidosis. This was further validated by agreement among the 3 readers. Early time-point imaging is preferred, and additional delayed imaging can be acquired when the early result is equivocal.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"140-145"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can an Abnormal Gastric Emptying Study Be Normal?","authors":"Ben Freiberg","doi":"10.2967/jnmt.124.269182","DOIUrl":"10.2967/jnmt.124.269182","url":null,"abstract":"<p><p>The American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine and Molecular Imaging collaboratively wrote consensus statements to standardize gastric emptying scintigraphy. Despite this, centers are using nonstandard protocols. This study examined how these protocols contrast with standards. <b>Methods:</b> Consecutive charts were analyzed for meal, radionuclide dose, half-emptying time (T½) and its normal range, and documented retention and emptying. Impressions were compared with how emptying mapped on a graph based on standard 4-h values. <b>Results:</b> Thirty-four studies were identified. Ten of 14 abnormal studies were normal when plotted on the standard 4-h graph. Eight of 10 abnormal studies had normal 2- or 4-h retention. Normal T½ ranges varied significantly. Most altered the meal, and over 25% received a radionucleotide dose outside the recommended range. <b>Conclusion:</b> The upper bound of normal T½ falls within standard 4-h bounds, with many individuals given an erroneous impression. Though further optimization may be needed, adhering to standards is critical.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"158-161"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sunil R Selvin, Erin Stevens, Mary Beth Farrell, Gary V Heller
{"title":"Patient Motion During Cardiac PET Imaging.","authors":"Sunil R Selvin, Erin Stevens, Mary Beth Farrell, Gary V Heller","doi":"10.2967/jnmt.125.269911","DOIUrl":"10.2967/jnmt.125.269911","url":null,"abstract":"<p><p>Cardiac PET imaging is increasingly used for myocardial perfusion studies because of its high diagnostic accuracy and low radiation exposure to the patient. However, patient motion can be challenging, affecting a large number of studies. Motion artifacts can lead to inconclusive or false-positive results, complicating clinical interpretation. This article explores the causes of motion artifacts and their characteristic appearance in cardiac PET imaging, highlighting their distinction from true perfusion abnormalities. Strategies for minimizing motion through effective patient positioning and communication are discussed. Understanding and addressing motion artifacts are crucial for optimizing diagnostic accuracy and ensuring the full benefit of cardiac PET imaging.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"135-137"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reja E A Schaaf, Hein J Verberne, Dave A Dongelmans
{"title":"<sup>18</sup>F-FDG Myocardial Uptake Related to Continuous Venovenous Hemodialysis: The Importance of Eliminating All Things Sweet.","authors":"Reja E A Schaaf, Hein J Verberne, Dave A Dongelmans","doi":"10.2967/jnmt.124.268968","DOIUrl":"10.2967/jnmt.124.268968","url":null,"abstract":"<p><p>When <sup>18</sup>F-FDG PET/CT is used to diagnose cardiovascular inflammation or infection, it is important to differentiate between pathologic and physiologic <sup>18</sup>F-FDG myocardial uptake. Several methods to suppress physiologic <sup>18</sup>F-FDG myocardial uptake have been reported, all based on the principle of promoting free fatty acid metabolism over glucose metabolism. However, despite rigorous implementation of these protocols, there is variation in successful myocardial glucose suppression. Sometimes this variation can be explained by specific patient conditions or treatment regimes. Here, we describe a patient on continuous venovenous hemodialysis with <sup>18</sup>F-FDG myocardial uptake despite adequate preparation.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"174-175"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empowering Technologists, Elevating Care.","authors":"Julie Dawn Bolin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 2","pages":"7A-8A"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myocardial Sympathetic Innervation Imaging.","authors":"Justin G Peacock, Mary Beth Farrell","doi":"10.2967/jnmt.125.270093","DOIUrl":"10.2967/jnmt.125.270093","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"101-103"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kara Weatherman, Erin Elizabeth Grady, Nic Mastascusa, Sara Johnson, George H Hinkle, Richard Laforest, Chloee Wendorf, Kathy S Thomas
{"title":"The SNMMI/ACNM Practice Guideline for the Use of Radiopharmaceuticals 5.0.","authors":"Kara Weatherman, Erin Elizabeth Grady, Nic Mastascusa, Sara Johnson, George H Hinkle, Richard Laforest, Chloee Wendorf, Kathy S Thomas","doi":"10.2967/jnmt.125.269834","DOIUrl":"10.2967/jnmt.125.269834","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"130-134"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justin G Peacock, Haley Majot, Avani T Bansal, Patrick Neshiwat, Kelsy Dimeff, Kalpna Prasad
{"title":"Illuminating the Hidden: Standardizing Cardiac MIBG Imaging for Sympathetic Dysfunction.","authors":"Justin G Peacock, Haley Majot, Avani T Bansal, Patrick Neshiwat, Kelsy Dimeff, Kalpna Prasad","doi":"10.2967/jnmt.124.269436","DOIUrl":"10.2967/jnmt.124.269436","url":null,"abstract":"<p><p>The heart's innervation relies on a delicate balance between the sympathetic and parasympathetic nervous systems, each using distinct neurotransmitters to regulate heart rate, contractility, and vascular tone. The sympathetic division primarily uses norepinephrine, whereas the parasympathetic division operates through acetylcholine. A range of diseases, through intrinsic and extrinsic mechanisms, can disrupt these neural pathways, resulting in autonomic dysfunction. This review highlights intrinsic causes such as dysautonomias, amyloidosis, diabetes mellitus, Parkinsonian syndromes, and Lewy body dementia, as well as extrinsic factors such as heart failure, myocardial ischemia, infarction, and drug-induced cardiotoxicity. This article examines the effects of various conditions on cardiac sympathetic innervation and highlights how <sup>123</sup>I-radiolabeled metaiodobenzylguanidine (MIBG), a norepinephrine analog, can target the cardiac sympathetic nervous system for early detection and disease characterization. Currently, variability in cardiac <sup>123</sup>I-MIBG imaging protocols across institutions leads to inconsistencies in image acquisition and interpretation, limiting the establishment of universal benchmarks for distinguishing normal from abnormal cardiac sympathetic innervation. To address this, we propose a simple, clinically useful, standardized protocol based on European Association of Nuclear Medicine guidelines and the AdreView Myocardial Imaging for Risk Evaluation in Heart Failure trial, incorporating both qualitative and semiquantitative methods for disease assessment and highlight cutoff values for some pathologies that can assist in visual interpretation. Standardizing these protocols will enhance the consistency, reliability, and diagnostic accuracy of <sup>123</sup>I-MIBG imaging, improving clinical decision-making and optimizing patient outcomes.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"90-100"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improvement of Anatomic Alignment and Image Quality Using a Respiratory Motion Reduction Block in Oncologic PET/CT.","authors":"Hajime Ichikawa, Takayuki Shibutani, Toyohiro Kato, Tomoya Banno, Mitsuaki Terabe, Hideki Shimada","doi":"10.2967/jnmt.124.269096","DOIUrl":"10.2967/jnmt.124.269096","url":null,"abstract":"<p><p><sup>18</sup>F-FDG PET/CT is crucial for cancer diagnosis; however, respiratory motion often causes misregistration between PET and CT images. This study aimed to evaluate the impact of a custom-made respiratory motion reduction block (RRB) in reducing misregistration and improving image quality in <sup>18</sup>F-FDG PET/CT. <b>Methods:</b> The RRB was developed to minimize the effects of respiratory motion. It is a pentagonal block made of Styrofoam designed to compress the upper abdomen. This study included 170 patients who underwent whole-body <sup>18</sup>F-FDG PET/CT. Patients were categorized into 4 groups based on the CT and PET scanning technique used: a control free-breathing (FB) group (breath-holding [BH] CT without RRB and respiration-gated [RG] PET), a control RG group (BH CT without RRB with RG PET), a BH RRB group (BH CT with RRB), and a FB RRB group (FB CT with RRB). Various parameters, including the incidence rate and distance of anatomic misregistration, and signal-to-noise ratio, were measured and compared. <b>Results:</b> For the control FB, control RG, BH RRB, and FB RRB groups, the incidence rates of anatomic misregistration between PET and CT images were 47.1%, 27.5%, 34.0%, and 16.7%, respectively. The mean misregistration distances in these groups were 5.1 ± 6.0, 3.1 ± 5.5, 3.8 ± 6.2, and 1.3 ± 3.2 mm, respectively. Furthermore, the RRB improved the signal-to-noise ratio of the liver. <b>Conclusion:</b> The RRB effectively improved registration between PET and CT images. Our approach is cost-effective and provides respiratory motion suppression not only during PET but also during CT scans. The use of RRB with FB PET scanning was found to be more beneficial than respiratory gating.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"146-151"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}