Journal of nuclear medicine technology最新文献

{"title":"The SNMMI Procedure Standard/ACNM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 3.0.","authors":"Hung Q Dam, David C Brandon, Crystal G Gantz, Vesper V Grantham, Chen S Low, Harry W Schroeder, Michael G Stabin, Lionel S Zuckier","doi":"10.2967/jnmt.124.269004","DOIUrl":"https://doi.org/10.2967/jnmt.124.269004","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Dose Savings Associated with Personalized CT Scan Range in ¹⁸F-NaF Bone PET/CT.","authors":"Natalie A Bebbington, Helle D Zacho, Paw C Holdgaard","doi":"10.2967/jnmt.124.268246","DOIUrl":"https://doi.org/10.2967/jnmt.124.268246","url":null,"abstract":"<p><p>A disadvantage of ¹⁸F-NaF PET/CT compared with other types of bone scintigraphy is the additional radiation dose from the standard whole-body CT scan for lesion localization and characterization (L/C). This study investigated whether the L/C CT region can be personalized to reduce CT radiation dose, according to uptake in the PET images. <b>Methods:</b> Attenuation-corrected ¹⁸F-NaF PET images were reviewed for the clinically required L/C CT range by 1 medical observer and 1 technologist observer in 25 patients with breast cancer scanned before neoadjuvant chemotherapy. For each patient, effective doses were estimated for whole-body L/C CT, personalized L/C CT, and whole-body CT for attenuation correction only. Dose savings for the personalized method incorporating both whole-body CT for attenuation correction and personalized L/C CT were expressed relative to standard whole-body L/C CT. The clinical impact of the personalized method was determined by evaluating whether lesions clinically requiring coverage had been missed from the L/C CT region. <b>Results:</b> Potential dose savings of 43%-54% were estimated for the personalized CT method, according to the observers. From the 25 patients reviewed, the medical observer did not miss any clinically significant lesions from the L/C CT region, whereas the technologist observer missed 2 clinically significant lesions of 61 suggestive lesions identified by medical observer follow-up. <b>Conclusion:</b> Mean CT dose could be reduced by around half in this patient group with personalized CT. Future work should further evaluate whether this method can be implemented in clinical practice without compromising clinical image evaluation.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo Simulation of Characteristics of Discovery NM/CT 670 Pro SPECT System for Routinely Used Diagnostic and Therapeutic Radionuclides.","authors":"Viraj Sawant, Sneha Mithun, Ashish K Jha, Venkatesh Rangarajan","doi":"10.2967/jnmt.124.268696","DOIUrl":"https://doi.org/10.2967/jnmt.124.268696","url":null,"abstract":"<p><p>The collimator in the SPECT imaging system is a critical component that uniquely influences image quality. Collimator selection for the imaging of the specific isotope is of the utmost importance. This study used Monte Carlo simulations to evaluate the response of different collimators for commonly used radionuclides in SPECT imaging. <b>Methods:</b> The Simulating Medical Imaging Nuclear Detectors Monte Carlo program was used to simulate the Discovery NM/CT 670 Pro SPECT system equipped for a collimator-radionuclide pair to optimize the selection of the collimator for SPECT imaging. Low-energy high-resolution (LEHR), medium-energy general-purpose (MEGP), and high-energy general-purpose (HEGP) collimators were simulated with ^99mTc, ¹⁷⁷Lu, and ¹³¹I point sources (1 MBq) to evaluate spatial resolution, sensitivity, scatter fraction, and septal penetration. The results were analyzed for the optimization of the collimator-radionuclide pair. <b>Results:</b> For ^99mTc (γ-energy, 140 keV), the resolution (full width at half maximum), sensitivity, scatter fraction, and septal penetration for LEHR, MEGP, and HEGP were 7.03 mm, 189 counts per minute (cpm)/μCi, 3.50%, and 2.65%; 9.3 mm, 184 cpm/μCi, 2.32%, and 1.35%; and 11.3 mm, 224 cpm/μCi, 2.05%, and 1.27%, respectively. For ¹⁷⁷Lu (γ-energy, 113 and 208 keV), the respective values were 7.5 mm, 62.52 cpm/μCi, 22.22%, and 18.56%; 9.6 mm, 20 cpm/μCi, 3.36%, and 2.19%; and 12.03 mm, 25 cpm/μCi, 2.88%, and 1.89%. For ¹³¹I (γ-energy, 364 keV), the respective values were 11.5 mm, 6,027 cpm/μCi, 28.80%, and 49.78%; 11.3 mm, 152 cpm/μCi, 43.49%, and 32.89%; and 14.08 mm, 86 cpm/μCi, 23.85%, and 17.96%. <b>Conclusion:</b> The study highlighted the need to understand collimator characteristics as a function of photon energy, where quantitative evaluation is the main aspect. The study suggests that the collimators that had optimal characteristics for imaging with ^99mTc, ¹⁷⁷Lu, and ¹³¹I were the LEHR, MEGP, and HEGP collimators, respectively.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robustness of ¹⁸F-FDG PET Radiomic Features in Lung Cancer: Impact of Advanced Reconstruction Algorithm.","authors":"Pooja Dwivedi, Sagar Barage, Ashish Kumar Jha, Sayak Choudhury, Venkatesh Rangarajan","doi":"10.2967/jnmt.124.268252","DOIUrl":"https://doi.org/10.2967/jnmt.124.268252","url":null,"abstract":"<p><p>¹⁸F-FDG PET radiomics is emerging as a promising tool to identify imaging biomarkers for quantifying intratumor heterogeneity in lung cancer. However, the robustness of PET radiomic features (RFs) is influenced by factors such as image reconstruction algorithms, tumor segmentation, and discretization. Although the impact of these factors on RFs has been explored, the specific influence of the advanced block sequential regularized expectation maximization (BSREM) reconstruction algorithm remains unclear. This study investigated the potential variations in PET RFs associated with different factors when using BSREM. <b>Methods:</b> Retrospective data of ¹⁸F-FDG PET from 120 lung cancer patients were reconstructed twice using advanced BSREM and conventional ordered-subset expectation maximization methods. For each reconstruction set, 3 tumor segmentations were performed, including manual, 40% threshold, and Nestle methods. Two discretization methods using absolute and relative settings were applied for each dataset before RF extraction. Stable and robust RFs were assessed by the coefficient of variance and intraclass correlation coefficient, respectively. <b>Results:</b> High instability was exhibited by 19%, 33%, and 36% of RFs, with a coefficient of variation of more than 20% for reconstruction, segmentation, and discretization, respectively. Conversely, 60%, 19%, and 35% of RFs demonstrated robustness against these factors, with an intraclass correlation coefficient of more than 0.90. The comparative evaluation revealed significantly greater robustness for most RF subtypes in BSREM than in ordered-subset expectation maximization under varying segmentation and discretization conditions (<i>P</i> < 0.05). <b>Conclusion:</b> The stability and robustness of PET RFs are enhanced if BSREM is applied rather than the conventional method. Study results suggest that the advanced reconstruction method could offer potential benefits in providing consistent PET-based radiomic analysis for improving diagnostic and prognostic value.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG Myocardial Uptake Related to Continuous Venovenous Hemodialysis: The Importance of Eliminating All Things Sweet.","authors":"Reja E A Schaaf, Hein J Verberne, Dave A Dongelmans","doi":"10.2967/jnmt.124.268968","DOIUrl":"https://doi.org/10.2967/jnmt.124.268968","url":null,"abstract":"<p><p>When ¹⁸F-FDG PET/CT is used to diagnose cardiovascular inflammation or infection, it is important to differentiate between pathologic and physiologic ¹⁸F-FDG myocardial uptake. Several methods to suppress physiologic ¹⁸F-FDG myocardial uptake have been reported, all based on the principle of promoting free fatty acid metabolism over glucose metabolism. However, despite rigorous implementation of these protocols, there is variation in successful myocardial glucose suppression. Sometimes this variation can be explained by specific patient conditions or treatment regimes. Here, we describe a patient on continuous venovenous hemodialysis with ¹⁸F-FDG myocardial uptake despite adequate preparation.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation Lung Imaging: Technegas.","authors":"Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle","doi":"10.2967/jnmt.125.269536","DOIUrl":"https://doi.org/10.2967/jnmt.125.269536","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Logistics of Adopting ¹⁷⁷Lu-Vipivotide Tetraxetan Therapy in a Community-Based Hospital Setting.","authors":"Kathleen Marsh, Kayla Allickson, Amanda Jesz, Cheryl Hanson, Donna Newman, Erica Martin-Macintosh","doi":"10.2967/jnmt.124.268039","DOIUrl":"https://doi.org/10.2967/jnmt.124.268039","url":null,"abstract":"<p><p>Prostate cancer is a leading cause of cancer death in men. Advanced disease may progress to metastatic castration-resistant prostate cancer. In March 2022, ¹⁷⁷Lu-vipivotide tetraxetan was U.S. Food and Drug Administration-approved for patients with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer who have previously received other therapies, including androgen deprivation and taxane therapies. <b>Methods:</b> Although preliminary data for ¹⁷⁷Lu-vipivotide tetraxetan has shown extension of overall survival of patients, there is little literature about realistically initiating ¹⁷⁷Lu-vipivotide tetraxetan into non-academic-based clinical practices. <b>Results:</b> This article presents a multidisciplinary practice implementation workflow for ¹⁷⁷Lu-vipivotide tetraxetan. It also highlights the challenges and considerations for initiating such a theranostics practice. <b>Conclusion:</b> The aim of this work is to help nontertiary medical centers improve patient accessibility for beneficial radiopharmaceutical therapies, specifically ¹⁷⁷Lu-vipivotide tetraxetan.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technegas at Last! Implementing Technegas into Clinical Practice in the United States: Considerations, Challenges, and Recommendations.","authors":"Delynn Silvestros, Tina M Buehner","doi":"10.2967/jnmt.124.269231","DOIUrl":"https://doi.org/10.2967/jnmt.124.269231","url":null,"abstract":"<p><p>Technegas, ^99mTc-labeled aerosolized carbon nanoparticles, has been used internationally since 1986 for pulmonary ventilation imaging. Unlike traditional gases, Technegas exhibits only a gaslike behavior, allowing deep and uniform deposition in the lungs' subsegmental regions. This hydrophobic property minimizes central airway clumping, as is particularly advantageous for patients with chronic obstructive pulmonary disease. Approved by the U.S. Food and Drug Administration in September 2023, Technegas is now available in the United States for diagnosing pulmonary embolism and broader ventilation and airway evaluations. The Technegas Plus system, which produces the radioaerosol onsite by heating [^99mTc]sodium pertechnetate in a carbon crucible at ultrahigh temperatures, requires a specific infrastructure, including a 220-volt power supply and an argon gas source. Its rapid administration-often requiring only 1-3 breaths-streamlines workflows while ensuring patient comfort, especially for those with respiratory limitations. Additionally, Technegas supports SPECT and SPECT/CT imaging, enabling sensitivity and specificity superior to those of traditional planar methods. Despite the global adoption of ventilation-perfusion SPECT as the standard for pulmonary embolism diagnosis, its use in the United States remains limited. Now that Technegas is available in the United States, U.S. nuclear medicine departments can transition to advanced ventilation imaging, aligning with international best practices. This paper outlines essential considerations for Technegas implementation: infrastructure requirements, staff training, protocol development, and imaging optimization, including clinical experiences and perspectives from the staff at Barnes Jewish Hospital in St. Louis, Missouri. By integrating Technegas, departments can enhance diagnostic accuracy, improve workflow efficiency, and expand clinical applications, particularly for patients with complex pulmonary conditions.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Residual [^99mTc]Tc-Tetrofosmin Activity in Routine Nuclear Medicine Practice at Hospital Kuala Lumpur.","authors":"Ren Yi Fong, Nurul Maisara Jaffar, Rachel Jen Lyn Chung, Hui Ling Tong, Syifaa' Aminudin, Kee Wei Lau","doi":"10.2967/jnmt.124.268886","DOIUrl":"https://doi.org/10.2967/jnmt.124.268886","url":null,"abstract":"<p><p>Myocardial perfusion imaging using the radiopharmaceutical [^99mTc]Tc-tetrofosmin plays a crucial role in diagnosing cardiac conditions. However, variations in the residual activity of [^99mTc]Tc-tetrofosmin in plastic syringes after administration may impact imaging quality and patient safety. This study aimed to evaluate the residual activity of [^99mTc]Tc-tetrofosmin in plastic syringes after administration during routine nuclear medicine procedures at Hospital Kuala Lumpur, assessing compliance with department protocols and variability among different syringe brands. <b>Methods:</b> A single-center prospective observational study was conducted using stratified quota sampling, encompassing 396 samples across 3 syringe brands (SJ, BD, and Ciringe). Residual activity was measured immediately after administration, and statistical analysis was performed to compare brands and assess compliance with the department dosage protocol range of 333-555 MBq. <b>Results:</b> All injected activities aligned with the department protocol dose, with a mean effective activity of 451.23 ± 30.73 MBq and a mean residual activity of 12.63% ± 4.73%. However, variability in residual activity was observed among syringe brands. BD exhibited the highest mean residual activity (16.45%), significantly differing from SJ (9.95%) and Ciringe (11.50%) (<i>P</i> < 0.001). <b>Conclusion:</b> Rigorous syringe selection is crucial in myocardial perfusion imaging procedures to minimize residual activity and ensure compliance with dosimetry standards, emphasizing the importance of integrating pharmacy practices into nuclear medicine protocols. Standardized protocols and quality assurance measures are essential to optimize imaging outcomes and prioritize patient safety. These findings highlight the importance of ongoing monitoring and interdisciplinary collaboration to navigate residual activity management effectively in routine nuclear medicine practice.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Arthrography Improve Accuracy of SPECT/CT for Diagnosis of Aseptic Loosening in Patients with Painful Knee Arthroplasty: A Systematic Review and Metaanalysis.","authors":"Charlie Timon, Aoife Feeley, John Mahon, Iain Feeley, John Quinlan, Eoin Sheehan","doi":"10.2967/jnmt.123.266050","DOIUrl":"https://doi.org/10.2967/jnmt.123.266050","url":null,"abstract":"<p><p>SPECT/CT combines scintigraphy with a CT scan forming a 3-dimensional reconstruction of bone-tracer uptake patterns. It has become a fundamental component of the work-up of a painful total knee arthroplasty (TKA). The addition of an arthrogram is purported to improve its diagnostic yield. The aim of this study was to assess whether the addition of a concurrent arthrogram to a SPECT/CT enhances its sensitivity and specificity for diagnosing aseptic loosening in a painful total knee replacement. <b>Methods:</b> PubMed, Embase, and Scopus were searched in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies compared the results of SPECT/CT with or without an arthrogram against an appropriate reference standard for diagnosing TKA aseptic loosening. The quality of included studies was independently assessed using the QUADAS-2 tool. <b>Results:</b> In total, 160 abstracts were identified by our search strategy. Of these, 6 studies comprising 472 patients met our inclusion criteria. All included studies used operative findings or a period of clinical and radiologic observation as reference standards. The SPECT/CT arthrogram was more sensitive in identifying aseptic loosening of knee prostheses, and it also provided greater specificity for excluding its diagnosis. <b>Conclusion:</b> The amalgamated results of included studies of the use of SPECT/CT demonstrate it is the best test in helping determine aseptic loosening in patients with painful TKAs (specificity, 97% vs. 85%). It is also a more sensitive test (sensitivity, 78% vs. 75%). Considering the potential morbidity of injection of contrast into the prosthetic joint, addition of an arthrogram to SPECT/CT is not beneficial and is potentially harmful.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}