Journal of nuclear medicine technology最新文献

{"title":"Clinical Evaluation of BSREM Reconstruction in Pediatric Oncology Using [¹⁸F]FDG PET/CT.","authors":"Nicholas A Shkumat, Reza Vali, Amer Shammas","doi":"10.2967/jnmt.125.269555","DOIUrl":"https://doi.org/10.2967/jnmt.125.269555","url":null,"abstract":"<p><p>Recent technologic advancements in PET, including silicon photomultipliers and block-sequential regularized expectation maximization (BSREM) tools, have allowed for renewed assessment of the optimal acquisition and reconstruction parameters in pediatric imaging. This work evaluates the performance of BSREM reconstruction and varied count density (CD) in digital [¹⁸F]FDG PET/CT to investigate the feasibility of reducing the injected activity or duration of acquisition in children with cancer. <b>Methods:</b> Five hundred unique reconstructions from 20 pediatric patients evaluated with PET/CT per clinical standard of care (SOC) were included in this retrospective study. Three-dimensional, whole-body imaging was acquired on a silicon photomultiplier PET/CT system in list mode with time-of-flight modeling. Imaging volumes were reconstructed with varying time per bed position (180, 120, 90, 60, and 45 s) to simulate a range of CDs using conventional iterative techniques (ordered-subset expectation maximization) and BSREM with varied regularization strength (β, 175-700). Two pediatric nuclear medicine physicians individually scored all studies, with patient information, reconstruction method, and CD concealed, rating technical quality and overall diagnostic satisfaction on a 5-point Likert scale. Quantitative SUV measurements on all reconstructions were compared with the clinical SOC. <b>Results:</b> Reconstruction with BSREM with a β of 500 or greater significantly improved overall scores across all CDs when compared with ordered-subset expectation maximization. Noise performance improved after application of a higher regularization parameter. Spatial resolution (sharpness) was greatest with a β of 350. Mean overall image quality at 25% CD using a β of 500 or greater was considered diagnostic. Mean liver and blood-pool SUV-to-noise ratio performed best with the highest β and CD. SUV_max behavior was complex, varying with reconstruction strength and CD, with measurements at β of 500 or greater differing from the SOC by no more than 15% across all CDs, and specific combinations varying by 10% or less. <b>Conclusion:</b> Clinical evaluation of whole-body [¹⁸F]FDG PET/CT in pediatric patients was diagnostic at all reductions in CD when using BSREM with a β of 500 or greater. Quantitative performance was variable, yet SUV_max differences of 10% or less were achievable with the appropriate selection of acquisition and reconstruction parameters. This study found that customized imaging parameters can reduce injected activity (radiation dose) and imaging time to best suit the pediatric patient.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrous Dysplasia of Frontal Process of Maxilla: False-Positive Finding on ¹⁸F-FDG PET in Multiple Myeloma.","authors":"Fathima Fijula Palot Manzil, Pokhraj Suthar, Surjith Vattoth","doi":"10.2967/jnmt.125.270668","DOIUrl":"https://doi.org/10.2967/jnmt.125.270668","url":null,"abstract":"<p><p>¹⁸F-FDG focal uptake in bone is always concerning, especially in patients with a history of cancer. We report a case of increasing hypermetabolic activity of a maxillary bone lesion in a patient with a history of multiple myeloma that was managed with definitive treatment. A targeted CT scan revealed that the abnormal ¹⁸F-FDG uptake was fibrous dysplasia. Vigilant interpretation is required for focal osseous activity on PET/CT in patients with a history of cancer to avoid false-positive readings.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Detection of Meningioma on ^99mTc-Sestamibi SPECT: A Case Report.","authors":"Mürsel Daşar, Koray Demirel, Gökhan Koca, Aylin Akbulut, Meliha Korkmaz","doi":"10.2967/jnmt.125.270437","DOIUrl":"https://doi.org/10.2967/jnmt.125.270437","url":null,"abstract":"<p><p>A 64-y-old woman presented to our hospital with general weakness, difficulty walking, and a history of kidney stones. Laboratory findings revealed elevated parathyroid hormone and calcium levels. ^99mTc-sestamibi SPECT imaging was performed to evaluate suspected parathyroid adenoma. Although no uptake characteristic of parathyroid adenoma was observed, a focal uptake with delayed washout was unexpectedly detected in the right frontal lobe. Subsequent MRI confirmed the lesion as a meningioma. This case underscores the diagnostic value of ^99mTc-sestamibi scintigraphy in detecting incidental cranial lesions, emphasizing its role in guiding further imaging and clinical management.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of PSMA-Targeted Theranostics into Multidisciplinary Care for Improved Efficiencies and Patient Care.","authors":"Phillip H Kuo, Erasmus Kofi Poku, Dave M Yamauchi, Susan H Cha, Maria L Parayno, Nicole E Chong, Charles B Nguyen, Sandy T Liu, Alexander M Chehrazi-Raffle, Abhishek Tripathi, Benjamin S Gerendash, Kathleen D Burns, Tanya B Dorff","doi":"10.2967/jnmt.125.270053","DOIUrl":"https://doi.org/10.2967/jnmt.125.270053","url":null,"abstract":"<p><p>The widespread success of ¹⁷⁷Lu-PSMA-617 for prostate cancer has generated unprecedented volume in theranostics. Prostate-specific membrane antigen-targeted theranostics is possibly the most complex program in nuclear medicine, requiring interpretation of prostate-specific membrane antigen PET according to specific criteria, incorporating laboratory tests, and on-treatment imaging to guide patient management. Adding to the complexity, these patients often have aggressive disease biology, toxicities from multiple failed therapies, and significant comorbidities. This combination of complexity and growing number of patients has created the critical need for efficient integration of theranostics into regular practice. We describe here the key components of our evolving program and protocols that have improved patient care delivery within our health system. At the core of the program is the establishment of a dedicated multidisciplinary team and regular conference to provide a forum to discuss challenging cases and issues. The creation and distribution of guidelines for imaging and laboratory criteria are critical for streamlining care so that cases are properly selected for further discussion.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[^99mTc]Tc-Sestamibi/[^99mTc]NaTcO₄ Subtraction SPECT of Parathyroid Glands Using Analysis of Principal Components.","authors":"Irena Maříková, Soňa Balogová, David Zogala, Václav Ptáčník, Ivan Raška, Petr Libánský, Jean-Noël Talbot, Martin Šámal, Jiří Trnka","doi":"10.2967/jnmt.125.270082","DOIUrl":"10.2967/jnmt.125.270082","url":null,"abstract":"<p><p>The aim of the study was to validate a new method for semiautomatic subtraction of [^99mTc]Tc-sestamibi and [^99mTc]NaTcO₄ SPECT 3-dimensional datasets using principal component analysis (PCA) against the results of parathyroid surgery and to compare its performance with an interactive method for visual comparison of images. We also sought to identify factors that affect the accuracy of lesion detection using the two methods. <b>Methods:</b> Scintigraphic data from [^99mTc]Tc-sestamibi and [^99mTc]NaTcO₄ SPECT were analyzed using semiautomatic subtraction of the 2 registered datasets based on PCA applied to the region of interest including the thyroid and an interactive method for visual comparison of the 2 image datasets. The findings of both methods were compared with those of surgery. Agreement with surgery was assessed with respect to the lesion quadrant, affected side of the neck, and the patient positivity regardless of location. <b>Results:</b> The results of parathyroid surgery and histology were available for 52 patients who underwent [^99mTc]Tc-sestamibi/[^99mTc]NaTcO₄ SPECT. Semiautomatic image subtraction identified the correct lesion quadrant in 46 patients (88%), the correct side of the neck in 51 patients (98%), and true pathologic lesions regardless of location in 51 patients (98%). Visual interactive analysis identified the correct lesion quadrant in 44 patients (85%), correct side of the neck in 49 patients (94%), and true pathologic lesions regardless of location in 50 patients (96%). There was no significant difference between the results of the 2 methods (<i>P</i> > 0.05). The factors supporting lesion detection were accurate positioning of the patient on the camera table, which facilitated subsequent image registration of the neck, and, after excluding ectopic parathyroid glands, focusing detection on the thyroid ROI. <b>Conclusion:</b> The results of semiautomatic subtraction of [^99mTc]Tc-sestamibi/[^99mTc]NaTcO₄ SPECT using PCA had good agreement with the findings from surgery as well as the visual interactive method, comparable to the high diagnostic accuracy of [^99mTc]Tc-sestamibi/[¹²³I]NaI subtraction scintigraphy and [¹⁸F]fluorocholine PET/CT reported in the literature. The main advantages of semiautomatic subtraction are minimum user interaction and automatic adjustment of the subtraction weight. Principal component images may serve as optimized input objects, potentially useful in machine-learning algorithms aimed at fully automated detection of hyperfunctioning parathyroid glands.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Availability of Radiopharmaceuticals and Imaging Equipment in English-Speaking African Countries.","authors":"Lerato S Mosima, Amanda E Manicum, Beverley Summers","doi":"10.2967/jnmt.125.270432","DOIUrl":"https://doi.org/10.2967/jnmt.125.270432","url":null,"abstract":"<p><p>Radiopharmaceutical services are key in cancer screening, diagnosis, staging, treatment monitoring, detection of remission, and therapy. Unfortunately, due to the high costs of these services, their availability is very limited in developing countries. This study highlights issues related to access to radiopharmaceuticals and imaging equipment in English-speaking African countries. <b>Methods:</b> The study used a cross-sectional, quantitative online survey approach. <b>Results:</b> Findings revealed that only 13 of the 24 English-speaking African countries have nuclear medicine sites; 62% of countries with nuclear medicine sites rely on sole suppliers for ⁹⁹Mo/^99mTc generators. Of these countries, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe procure their generators only from South Africa, whereas Kenya, Mauritius, and Sudan procure theirs solely from European countries and Turkey. Cameroon, Ethiopia, Ghana, Namibia, and Nigeria procure generators from multiple countries. South Africa is the only English-speaking African country that commercializes radiopharmaceuticals and therefore has the greatest access to radiopharmaceuticals in this region. Only 23% of English-speaking African countries having access to PET services and theranostics. <b>Conclusion:</b> Gaps in access to radiopharmaceuticals among English-speaking African countries have been identified and are largely due to the lack of equipment and poor infrastructure. Plans to strengthen access to radiopharmaceuticals in some of the countries in this region are under way. Our survey found that 331,758,822 people from 11 English-speaking African countries from the region have no access to radiopharmaceutical services.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Diagnostic Reference Levels for Nuclear Medicine in Brazil: Insights from a University Hospital.","authors":"Lucas Paixão, Luciene G Mota, Stephanie S Freitas, Sandra M Dumont","doi":"10.2967/jnmt.125.270129","DOIUrl":"https://doi.org/10.2967/jnmt.125.270129","url":null,"abstract":"<p><p>Diagnostic reference levels (DRLs) are essential for optimizing radiologic practices and ensuring patient safety. This study aimed to establish typical DRLs for nuclear medicine (NM) procedures performed at a Brazilian public university hospital. <b>Methods:</b> A retrospective analysis of 2,609 patient records from 13 routine NM procedures was conducted. Administered activities were analyzed to determine typical DRLs using the median (50th percentile), and data dispersion was evaluated using the interquartile range. Effective doses were estimated on the basis of International Commission on Radiological Protection dose coefficients. <b>Results:</b> For most procedures, typical DRLs were below the national reference levels, indicating optimized practices. Two procedures (static renal and parathyroid scintigraphy) had DRLs exceeding national values because of specific protocol adjustments. Elevated variability was observed in myocardial perfusion (1-d protocol) and lung perfusion procedures, attributed to clinical workflow constraints and individualized adjustments based on patient condition or clinical indications. Dosimetric estimates confirmed that all procedures were within safe exposure limits. <b>Conclusion:</b> This study reinforces the importance of establishing typical DRLs as a foundation for national DRL updates. The results provide valuable insights for optimizing NM practices in Brazil, supporting radiologic protection, and improving patient safety.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Glomerular Filtration Rate Estimation: A Simplified Method for Improved Accuracy and Efficiency.","authors":"Elena Solfaroli Camillocci, Davide Ciucci, Claudia Polito, Salvatore Donatiello, Antonio Napolitano, Damiano Palmieri, Luigi Rinaldi, Andrea Apollonio, Maria Felicia Villani, Milena Pizzoferro, Claudio Altini, Maria Carmen Garganese, Vittorio Cannatà","doi":"10.2967/jnmt.125.270100","DOIUrl":"https://doi.org/10.2967/jnmt.125.270100","url":null,"abstract":"<p><p>The glomerular filtration rate (GFR) is a key measure of renal function, typically estimated using creatinine-based equations. More precise clearance measurements are obtained with radiotracers, such as [^99mTc]Tc-diethylenetriaminepentaacetic acid (DTPA), and blood samples over several hours. However, standard plasma clearance methods require labor-intensive plasma preparation, limiting efficiency in clinical practice. This study proposes a simplified approach to GFR estimation by directly measuring radioactivity in whole blood and applying a correction factor based on hematocrit, eliminating the need for blood centrifugation and reducing calibration steps. <b>Methods:</b> Sixty-seven adults and children undergoing GFR assessment with [^99mTc]Tc-DTPA were included in the study. GFR was estimated using both the standard plasma-based method and a whole-blood approach, which directly measured radioactivity in whole blood and applied a correction factor based on hematocrit. The γ-counter's response linearity and reproducibility were assessed to validate the correction factor. Comparisons between plasma-based and whole blood-derived GFRs were performed using linear regression and deviation analysis. <b>Results:</b> The γ-counter demonstrated a detection efficiency of 50.5% in the activity range of 30-150 kBq, confirming its reliability for whole-blood measurements. The proposed whole-blood method yielded GFRs that were highly correlated with the plasma-based approach, with an average deviation of 4%. Significant deviations (>15%) were observed in only 2 of 67 cases. The whole-blood method eliminated the need for plasma separation, reduced processing time, and maintained measurement accuracy. <b>Conclusion:</b> The proposed whole-blood approach provides a reliable alternative to standard plasma-based GFR estimation, simplifying sample preparation and reducing clinical workload. This method enhances efficiency in nuclear medicine while preserving measurement accuracy, making it a viable option for routine renal function assessment.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Momentum: A Year of Wins and Next Steps for SNMMI-TS.","authors":"Cybil J Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 3","pages":"7A-8A"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>JNMT</i> Outstanding Article Awards for 2024.","authors":"Kathy S Thomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 3","pages":"6A"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}