{"title":"Comparing Occupational Exposure from <sup>18</sup>F-FDG Injection Procedure Using a Traditional Injection Method Versus an Automated Injection System.","authors":"Raju Gupta, Shantanu Pande, Ashwini P Shinde","doi":"10.2967/jnmt.124.269103","DOIUrl":"https://doi.org/10.2967/jnmt.124.269103","url":null,"abstract":"<p><p>We evaluated occupational radiation exposure associated with <sup>18</sup>F-FDG injection using a traditional manual approach versus an automated injection system. <b>Methods:</b> Wrist and whole-body radiation exposure of nuclear medicine personnel using a manual injection method versus an automated injection system for <sup>18</sup>F-FDG administration were assessed using electronic personal dosimeters. Radiation exposure while configuring both systems was also evaluated. The dose administered met the requirements of the \"as low as reasonably achievable\" principle. Radiation exposure during initial setup and dose administration, residual activity, dose accuracy, presence of contamination, and frequency of extravasation were compared between methods. <b>Results:</b> Compared with the traditional manual method, use of the automated injection system resulted in significantly lower mean radiation exposure to medical physicists' wrists (<i>P</i> < 0.01). Radiation exposure was 79.41% lower at the wrist while using the automated injection system. Differences in whole-body radiation exposure were not significant between injection methods (<i>P</i> < 0.56). The overall radiation dose per injection at the wrist and in the whole body and mean residual activity after injection were noticeably lower with the automated system (<i>P</i> < 0.01), with mean residual activity decreasing by 73.58%. <b>Conclusion:</b> The overall radiation exposure for nuclear medicine personnel was significantly decreased when administering <sup>18</sup>F-FDG via an automated injection system.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Equine Bone Imaging, Part 2: Role of Nuclear Medicine in Racehorses.","authors":"Peter Tually, Geoffrey Currie","doi":"10.2967/jnmt.125.270050","DOIUrl":"https://doi.org/10.2967/jnmt.125.270050","url":null,"abstract":"<p><p>The horse racing industry, like any sport, must contend with the effects of injuries on an athlete's performance and longevity. Catastrophic fractures linked to preexisting bone fatigue can be prevented with the use of imaging technology, such as the nuclear medicine bone scan. The accessibility and affordability of imaging for racehorses remain obstacles. The conventional role of bone scintigraphy has evolved with the advent of advanced techniques, including MRI, CT, and PET. Concurrently, SPECT has expanded the role of scintigraphy in the racehorse. This article explores the conventional and contemporary role of bone scintigraphy in the racehorse. Some applications are transferrable to other athletic horses (e.g., equestrian) and stock horses. Nuclear medicine planar and SPECT imaging provide valuable insights into underlying causes of pain or lameness and represent an opportunity to prevent catastrophic injuries. The increasing demand for scintigraphy among racehorses also affords an opportunity for role diversity or alternative career pathways for nuclear medicine scientists and technologists.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger
{"title":"Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with <sup>68</sup>Ga-FAPI-46 PET/CT.","authors":"Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger","doi":"10.2967/jnmt.125.269645","DOIUrl":"https://doi.org/10.2967/jnmt.125.269645","url":null,"abstract":"<p><p>We sought to assess the diagnostic value of <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). <b>Methods:</b> In this retrospective study, 4 children with a diagnosis of jSSc underwent <sup>68</sup>Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. <b>Results:</b> In this case series, <sup>68</sup>Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. <b>Conclusion:</b> <sup>68</sup>Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using <sup>68</sup>Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Equine Bone Imaging, Part 1: Establishing an Equine Nuclear Medicine Facility.","authors":"Peter Tually, Geoffrey Currie","doi":"10.2967/jnmt.125.270049","DOIUrl":"https://doi.org/10.2967/jnmt.125.270049","url":null,"abstract":"<p><p>While the establishment and operation of an equine nuclear medicine department share several principles with those of human nuclear medicine departments, they require an additional skill set to ensure safe and effective operation. This article explores the practical aspects of equine nuclear medicine facility location and design and details important considerations for safe and practical operation. Key considerations associated with the differences in physical and radiation safety and imaging approaches are explored. Specific adaptations of γ-camera gantries to allow either planar imaging or SPECT in a standing horse are described. The skill set and insights of nuclear medicine scientists and technologists are crucial for the safe and effective establishment of an equine nuclear medicine facility.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastric-Emptying Pitfalls in Nuclear Medicine.","authors":"Sara G Johnson","doi":"10.2967/jnmt.125.270459","DOIUrl":"https://doi.org/10.2967/jnmt.125.270459","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prominent Right Ventricular Tracer Uptake: A Harbinger of Multivessel Coronary Artery Disease.","authors":"Adam Adam, Saurabh Malhotra","doi":"10.2967/jnmt.125.270002","DOIUrl":"10.2967/jnmt.125.270002","url":null,"abstract":"<p><p>A 65-y-old woman with multiple cardiovascular risk factors presented with atypical chest pain, prompting a 1-d pharmacologic stress myocardial perfusion test using <sup>99m</sup>Tc sestamibi. Initial interpretation suggested ischemia, but closer inspection revealed increased right ventricular uptake and increased left ventricular chamber size at stress, indicative of significant 3-vessel coronary artery disease (CAD). These findings were confirmed by cardiac catheterization, showing 3-vessel disease, including significant left main CAD. The patient underwent coronary artery bypass graft surgery. This case highlights the importance of meticulous SPECT image interpretation, particularly focusing on right ventricular uptake and transient ischemic dilation, to accurately diagnose severe CAD and improve cardiovascular outcomes.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"172-173"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lung Ventilation: Technegas.","authors":"Tina M Buehner","doi":"10.2967/jnmt.125.269769","DOIUrl":"10.2967/jnmt.125.269769","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"183"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ching-Liang Kuo, Rhoh-Fang Yen, Yao-Ming Wu, Mei-Hui Wang
{"title":"Phase I Study of <sup>68</sup>Ga-NOTA-HL for PET/CT Imaging of Hepatic Asialoglycoprotein Receptors in Healthy Volunteers.","authors":"Ching-Liang Kuo, Rhoh-Fang Yen, Yao-Ming Wu, Mei-Hui Wang","doi":"10.2967/jnmt.124.268430","DOIUrl":"10.2967/jnmt.124.268430","url":null,"abstract":"<p><p>This study investigated the safety, biodistribution, and dosimetry of <sup>68</sup>Ga-hexavalent lactoside (<sup>68</sup>Ga-NOTA-HL), a PET tracer targeting asialoglycoprotein receptors (ASGPRs) on hepatocytes. ASGPRs, key for glycoprotein homeostasis, serve as a valuable biomarker of liver function. <sup>68</sup>Ga-NOTA-HL demonstrated excellent safety in 12 healthy volunteers with no adverse events. Biodistribution studies revealed high liver uptake with minimal uptake in other organs, consistent with ASGPR targeting. The effective dose was 0.0289 mSv/MBq, indicating low radiation exposure. These findings suggest <sup>68</sup>Ga-NOTA-HL PET/CT holds significant promise as a safe and effective imaging technique for assessing liver function. The high liver specificity and extremely low background activity provide a strong foundation for further clinical investigations into its potential for evaluating liver function in various clinical settings, including the assessment of liver reserve in patients with liver diseases.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"152-157"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SPECT/CT for Discrimination Between Active and Inactive Os Trigonum in Posterior Ankle Syndrome.","authors":"Michael Pöhlmann, Martin Freesmeyer, Falk Gühne","doi":"10.2967/jnmt.124.269284","DOIUrl":"10.2967/jnmt.124.269284","url":null,"abstract":"<p><p>[<sup>99m</sup>Tc]-3,3-diphosphono-1,2-propanodicarboxylic acid bone scintigraphy was used to differentiate between posterior impingement syndrome and Haglund syndrome in a 34-y-old man with unclear right-sided ankle pain. The patient had an accessory os trigonum bilaterally, and previous x-ray, MRI, and CT were inconclusive. Using SPECT/CT with new iterative reconstruction algorithms based on CT images, the pathologic activation of bone metabolism at the right-sided os trigonum and the adjacent talus joint was revealed. Other causes of posterior ankle pain were ruled out, and posterior impingement syndrome was diagnosed.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"178-179"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diane K Soulek, Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle
{"title":"Cardiac Sarcoidosis Imaging: PET.","authors":"Diane K Soulek, Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle","doi":"10.2967/jnmt.125.269838","DOIUrl":"10.2967/jnmt.125.269838","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"113-115"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}