Journal of nuclear medicine technology最新文献

{"title":"The SNMMI Procedure Standard/ACNM Practice Guideline for Gastrointestinal Bleeding Scintigraphy 3.0.","authors":"Hung Q Dam, David C Brandon, Crystal G Gantz, Vesper V Grantham, Chen S Low, Harry W Schroeder, Michael G Stabin, Lionel S Zuckier","doi":"10.2967/jnmt.124.269004","DOIUrl":"10.2967/jnmt.124.269004","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"14-23"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Dose Savings Associated with Personalized CT Scan Range in ¹⁸F-NaF Bone PET/CT.","authors":"Natalie A Bebbington, Helle D Zacho, Paw C Holdgaard","doi":"10.2967/jnmt.124.268246","DOIUrl":"10.2967/jnmt.124.268246","url":null,"abstract":"<p><p>A disadvantage of ¹⁸F-NaF PET/CT compared with other types of bone scintigraphy is the additional radiation dose from the standard whole-body CT scan for lesion localization and characterization (L/C). This study investigated whether the L/C CT region can be personalized to reduce CT radiation dose, according to uptake in the PET images. <b>Methods:</b> Attenuation-corrected ¹⁸F-NaF PET images were reviewed for the clinically required L/C CT range by 1 medical observer and 1 technologist observer in 25 patients with breast cancer scanned before neoadjuvant chemotherapy. For each patient, effective doses were estimated for whole-body L/C CT, personalized L/C CT, and whole-body CT for attenuation correction only. Dose savings for the personalized method incorporating both whole-body CT for attenuation correction and personalized L/C CT were expressed relative to standard whole-body L/C CT. The clinical impact of the personalized method was determined by evaluating whether lesions clinically requiring coverage had been missed from the L/C CT region. <b>Results:</b> Potential dose savings of 43%-54% were estimated for the personalized CT method, according to the observers. From the 25 patients reviewed, the medical observer did not miss any clinically significant lesions from the L/C CT region, whereas the technologist observer missed 2 clinically significant lesions of 61 suggestive lesions identified by medical observer follow-up. <b>Conclusion:</b> Mean CT dose could be reduced by around half in this patient group with personalized CT. Future work should further evaluate whether this method can be implemented in clinical practice without compromising clinical image evaluation.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"80-86"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Software Discrepancies in Radionuclide-Derived Left Ventricular Ejection Fraction.","authors":"Rune H Kappel, Helle Precht, Thomas Q Christensen, Søren Hess, Martin W Kusk","doi":"10.2967/jnmt.124.268665","DOIUrl":"10.2967/jnmt.124.268665","url":null,"abstract":"<p><p>Gated equilibrium radionuclide angiography (ERNA), or multigated acquisition scanning, is a well-established technique to monitor left ventricular ejection fraction (LVEF) in patients treated with potentially cardiotoxic chemotherapy. To determine the results of a true change in LVEF, low inter- and intrareader variability is important. The aim of this study was to investigate inter- and intrareader variability in LVEF measurements using 2 different commercially available software packages with cardiac MR (CMR) as a reference standard. <b>Methods:</b> In 46 ERNA scans, LVEF was measured by 2 experienced nuclear medicine technologists, using the 2 software packages Xeleris and Corridor4DM. All patients had CMR performed within 1.5 h from ERNA. CMR-derived LVEF was measured by a cardiologist using cvi42 software. Eight patients were reanalyzed to investigate intrareader variability. Bland-Altman analysis was used to assess agreement between readers and software. Repeated-measures ANOVA was used to assess interactions between readers and software. Differences in mean LVEF were compared using a <i>t</i> test. The Lin concordance correlation coefficient (CCC) was used to test LVEF agreement between software packages and readers and the reference CMR results. <b>Results:</b> Corridor4DM had a significantly higher mean LVEF than did Xeleris. No significant interreader difference was observed within the same software. ANOVA found that readers did not influence LVEFs. The CCC between software packages was similar for both readers, at 0.409 for reader 1 and 0.418 for reader 2. Both software packages showed a significant LVEF bias compared with CMR (4% for Xeleris vs. 11% for Corridor4DM). For both readers, the CCC for correlation with MRI was higher for Xeleris (0.438/0.572) than for Corridor4DM (0.257/0.244). <b>Conclusion:</b> A high degree of variability was found between the 2 different software packages for the calculation of LVEF. No significant difference in LVEF was found between readers using the same software. Corridor4DM gave higher LVEF estimates than did Xeleris. Our findings suggest that different software programs for assessing LVEF in ERNA examinations are not interchangeable. The utmost caution is recommended if switching between different types of software.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"36-43"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 1","pages":"86"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technologist News.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 1","pages":"7A"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a Stronger Workforce: SNMMI-TS Progress and Partnerships.","authors":"Julie Dawn Bolin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 1","pages":"5A-6A"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo Simulation of Characteristics of Discovery NM/CT 670 Pro SPECT System for Routinely Used Diagnostic and Therapeutic Radionuclides.","authors":"Viraj Sawant, Sneha Mithun, Ashish K Jha, Venkatesh Rangarajan","doi":"10.2967/jnmt.124.268696","DOIUrl":"10.2967/jnmt.124.268696","url":null,"abstract":"<p><p>The collimator in the SPECT imaging system is a critical component that uniquely influences image quality. Collimator selection for the imaging of the specific isotope is of the utmost importance. This study used Monte Carlo simulations to evaluate the response of different collimators for commonly used radionuclides in SPECT imaging. <b>Methods:</b> The Simulating Medical Imaging Nuclear Detectors Monte Carlo program was used to simulate the Discovery NM/CT 670 Pro SPECT system equipped for a collimator-radionuclide pair to optimize the selection of the collimator for SPECT imaging. Low-energy high-resolution (LEHR), medium-energy general-purpose (MEGP), and high-energy general-purpose (HEGP) collimators were simulated with ^99mTc, ¹⁷⁷Lu, and ¹³¹I point sources (1 MBq) to evaluate spatial resolution, sensitivity, scatter fraction, and septal penetration. The results were analyzed for the optimization of the collimator-radionuclide pair. <b>Results:</b> For ^99mTc (γ-energy, 140 keV), the resolution (full width at half maximum), sensitivity, scatter fraction, and septal penetration for LEHR, MEGP, and HEGP were 7.03 mm, 189 counts per minute (cpm)/μCi, 3.50%, and 2.65%; 9.3 mm, 184 cpm/μCi, 2.32%, and 1.35%; and 11.3 mm, 224 cpm/μCi, 2.05%, and 1.27%, respectively. For ¹⁷⁷Lu (γ-energy, 113 and 208 keV), the respective values were 7.5 mm, 62.52 cpm/μCi, 22.22%, and 18.56%; 9.6 mm, 20 cpm/μCi, 3.36%, and 2.19%; and 12.03 mm, 25 cpm/μCi, 2.88%, and 1.89%. For ¹³¹I (γ-energy, 364 keV), the respective values were 11.5 mm, 6,027 cpm/μCi, 28.80%, and 49.78%; 11.3 mm, 152 cpm/μCi, 43.49%, and 32.89%; and 14.08 mm, 86 cpm/μCi, 23.85%, and 17.96%. <b>Conclusion:</b> The study highlighted the need to understand collimator characteristics as a function of photon energy, where quantitative evaluation is the main aspect. The study suggests that the collimators that had optimal characteristics for imaging with ^99mTc, ¹⁷⁷Lu, and ¹³¹I were the LEHR, MEGP, and HEGP collimators, respectively.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"30-35"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robustness of ¹⁸F-FDG PET Radiomic Features in Lung Cancer: Impact of Advanced Reconstruction Algorithm.","authors":"Pooja Dwivedi, Sagar Barage, Ashish Kumar Jha, Sayak Choudhury, Venkatesh Rangarajan","doi":"10.2967/jnmt.124.268252","DOIUrl":"10.2967/jnmt.124.268252","url":null,"abstract":"<p><p>¹⁸F-FDG PET radiomics is emerging as a promising tool to identify imaging biomarkers for quantifying intratumor heterogeneity in lung cancer. However, the robustness of PET radiomic features (RFs) is influenced by factors such as image reconstruction algorithms, tumor segmentation, and discretization. Although the impact of these factors on RFs has been explored, the specific influence of the advanced block sequential regularized expectation maximization (BSREM) reconstruction algorithm remains unclear. This study investigated the potential variations in PET RFs associated with different factors when using BSREM. <b>Methods:</b> Retrospective data of ¹⁸F-FDG PET from 120 lung cancer patients were reconstructed twice using advanced BSREM and conventional ordered-subset expectation maximization methods. For each reconstruction set, 3 tumor segmentations were performed, including manual, 40% threshold, and Nestle methods. Two discretization methods using absolute and relative settings were applied for each dataset before RF extraction. Stable and robust RFs were assessed by the coefficient of variance and intraclass correlation coefficient, respectively. <b>Results:</b> High instability was exhibited by 19%, 33%, and 36% of RFs, with a coefficient of variation of more than 20% for reconstruction, segmentation, and discretization, respectively. Conversely, 60%, 19%, and 35% of RFs demonstrated robustness against these factors, with an intraclass correlation coefficient of more than 0.90. The comparative evaluation revealed significantly greater robustness for most RF subtypes in BSREM than in ordered-subset expectation maximization under varying segmentation and discretization conditions (<i>P</i> < 0.05). <b>Conclusion:</b> The stability and robustness of PET RFs are enhanced if BSREM is applied rather than the conventional method. Study results suggest that the advanced reconstruction method could offer potential benefits in providing consistent PET-based radiomic analysis for improving diagnostic and prognostic value.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"50-56"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Data-Driven Gating FDG PET/CT for Abdominal Region.","authors":"Ryoma Ito, Kazuki Motegi, Kosuke Yamashita, Noriaki Miyaji, Mitsutomi Ishiyama, Naoki Shimada, Shohei Fukai, Takashi Terauchi","doi":"10.2967/jnmt.124.268350","DOIUrl":"10.2967/jnmt.124.268350","url":null,"abstract":"<p><p>This study aimed to validate the effectiveness of MotionFree (MF) in the abdominal region using 2 different PET/CT scanners to determine how to use MF efficiently. <b>Methods:</b> All 198 patients underwent respiratory-gated ¹⁸F-FDG PET/CT with MF. Imaging was performed using Discovery MI (DMI) and Discovery IQ (DIQ) PET/CT scanners, and all data were divided into 2 groups in each category (abdominal: upper and lower abdomen, lesion size, <20 mm and ≥20 mm; scanner group: DMI and DIQ). A physician assessed whether the respiratory motion artifacts were reduced with MF. The SUV change rate (ΔSUV) of 80 measurable lesions with and without MF was calculated. The relationship between the ΔSUVs and these groups was compared. <b>Results:</b> Motion artifacts were reduced in 62 of 198 patients (31.3%) in the upper abdomen, in 1 of 198 patients (0.5%) in the lower abdomen, in 51 of 98 patients (52.0%) in the DMI, and in 12 of 100 patients (12.0%) in DIQ with MF. ΔSUVs were significantly higher in the upper abdomen than in the lower abdomen. ΔSUV was up to 58.3% in DMI and up to 47.6% in DIQ. ΔSUVs of lesions with a size of less than 20 mm were significantly higher than those with a lesion size of 20 mm or greater. Although DMI was more effective than DIQ in terms of motion artifacts, both DMI and DIQ have the potential to increase the SUV with MF. MF significantly reduced the respiratory motion artifacts and increased the SUV for lesions smaller than 20 mm in the upper abdomen. <b>Conclusion:</b> MF reduced the motion artifacts in higher-spatial-resolution PET/CT images. In both PET/CT scanners, SUVs in lesions smaller than 20 mm and lesions in the upper abdomen increased significantly with MF. To use MF without increasing the acquisition time, it may be useful to apply it to the upper abdomen.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"24-29"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]FDG PET/CT in Metastatic Extragonadal Choriocarcinoma.","authors":"Ralph Emerson P, Sai Sradha Patro, Parneet Singh, Girish Kumar Parida, Kanhaiyalal Agrawal, Saurav Kumar Mishra","doi":"10.2967/jnmt.124.268758","DOIUrl":"10.2967/jnmt.124.268758","url":null,"abstract":"<p><p>Extragonadal choriocarcinoma in men is an extremely rare and highly aggressive malignancy. Inconclusive biopsies due to a high necrotic component often delay diagnosis. Here is such a case, in which suggestive imaging findings on [¹⁸F]FDG PET/CT, a raised level of serum β-human chorionic gonadotropin, and gynecomastia clinched the diagnosis.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"87-88"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}