Journal of nuclear medicine technology最新文献_第3页

Ventilation Lung Imaging: Technegas. 通气肺成像：Technegas。

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.125.269536

Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle

引用次数: 0

Logistics of Adopting ¹⁷⁷Lu-Vipivotide Tetraxetan Therapy in a Community-Based Hospital Setting. 在社区医院环境中采用177Lu-Vipivotide Tetraxetan治疗的后勤。

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.124.268039

Kathleen Marsh, Kayla Allickson, Amanda Jesz, Cheryl Hanson, Donna Newman, Erica Martin-Macintosh

{"title":"Logistics of Adopting 177Lu-Vipivotide Tetraxetan Therapy in a Community-Based Hospital Setting.","authors":"Kathleen Marsh, Kayla Allickson, Amanda Jesz, Cheryl Hanson, Donna Newman, Erica Martin-Macintosh","doi":"10.2967/jnmt.124.268039","DOIUrl":"10.2967/jnmt.124.268039","url":null,"abstract":"Prostate cancer is a leading cause of cancer death in men. Advanced disease may progress to metastatic castration-resistant prostate cancer. In March 2022, 177Lu-vipivotide tetraxetan was U.S. Food and Drug Administration-approved for patients with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer who have previously received other therapies, including androgen deprivation and taxane therapies. Methods: Although preliminary data for 177Lu-vipivotide tetraxetan has shown extension of overall survival of patients, there is little literature about realistically initiating 177Lu-vipivotide tetraxetan into non-academic-based clinical practices. Results: This article presents a multidisciplinary practice implementation workflow for 177Lu-vipivotide tetraxetan. It also highlights the challenges and considerations for initiating such a theranostics practice. Conclusion: The aim of this work is to help nontertiary medical centers improve patient accessibility for beneficial radiopharmaceutical therapies, specifically 177Lu-vipivotide tetraxetan.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"68-71"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Technegas at Last! Implementing Technegas into Clinical Practice in the United States: Considerations, Challenges, and Recommendations. Technegas终于来了！在美国临床实践中实施Technegas：考虑、挑战和建议。

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.124.269231

Delynn Silvestros, Tina M Buehner

{"title":"Technegas at Last! Implementing Technegas into Clinical Practice in the United States: Considerations, Challenges, and Recommendations.","authors":"Delynn Silvestros, Tina M Buehner","doi":"10.2967/jnmt.124.269231","DOIUrl":"10.2967/jnmt.124.269231","url":null,"abstract":"Technegas, 99mTc-labeled aerosolized carbon nanoparticles, has been used internationally since 1986 for pulmonary ventilation imaging. Unlike traditional gases, Technegas exhibits only a gaslike behavior, allowing deep and uniform deposition in the lungs' subsegmental regions. This hydrophobic property minimizes central airway clumping, as is particularly advantageous for patients with chronic obstructive pulmonary disease. Approved by the U.S. Food and Drug Administration in September 2023, Technegas is now available in the United States for diagnosing pulmonary embolism and broader ventilation and airway evaluations. The Technegas Plus system, which produces the radioaerosol onsite by heating [99mTc]sodium pertechnetate in a carbon crucible at ultrahigh temperatures, requires a specific infrastructure, including a 220-volt power supply and an argon gas source. Its rapid administration-often requiring only 1-3 breaths-streamlines workflows while ensuring patient comfort, especially for those with respiratory limitations. Additionally, Technegas supports SPECT and SPECT/CT imaging, enabling sensitivity and specificity superior to those of traditional planar methods. Despite the global adoption of ventilation-perfusion SPECT as the standard for pulmonary embolism diagnosis, its use in the United States remains limited. Now that Technegas is available in the United States, U.S. nuclear medicine departments can transition to advanced ventilation imaging, aligning with international best practices. This paper outlines essential considerations for Technegas implementation: infrastructure requirements, staff training, protocol development, and imaging optimization, including clinical experiences and perspectives from the staff at Barnes Jewish Hospital in St. Louis, Missouri. By integrating Technegas, departments can enhance diagnostic accuracy, improve workflow efficiency, and expand clinical applications, particularly for patients with complex pulmonary conditions.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"7-10"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Residual [^99mTc]Tc-Tetrofosmin Activity in Routine Nuclear Medicine Practice at Hospital Kuala Lumpur. 吉隆坡医院常规核医学实践中残留[99mTc]Tc-Tetrofosmin活性的评估

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.124.268886

Ren Yi Fong, Nurul Maisara Jaffar, Rachel Jen Lyn Chung, Hui Ling Tong, Syifaa' Aminudin, Kee Wei Lau

{"title":"Assessment of Residual [99mTc]Tc-Tetrofosmin Activity in Routine Nuclear Medicine Practice at Hospital Kuala Lumpur.","authors":"Ren Yi Fong, Nurul Maisara Jaffar, Rachel Jen Lyn Chung, Hui Ling Tong, Syifaa' Aminudin, Kee Wei Lau","doi":"10.2967/jnmt.124.268886","DOIUrl":"10.2967/jnmt.124.268886","url":null,"abstract":"Myocardial perfusion imaging using the radiopharmaceutical [99mTc]Tc-tetrofosmin plays a crucial role in diagnosing cardiac conditions. However, variations in the residual activity of [99mTc]Tc-tetrofosmin in plastic syringes after administration may impact imaging quality and patient safety. This study aimed to evaluate the residual activity of [99mTc]Tc-tetrofosmin in plastic syringes after administration during routine nuclear medicine procedures at Hospital Kuala Lumpur, assessing compliance with department protocols and variability among different syringe brands. Methods: A single-center prospective observational study was conducted using stratified quota sampling, encompassing 396 samples across 3 syringe brands (SJ, BD, and Ciringe). Residual activity was measured immediately after administration, and statistical analysis was performed to compare brands and assess compliance with the department dosage protocol range of 333-555 MBq. Results: All injected activities aligned with the department protocol dose, with a mean effective activity of 451.23 ± 30.73 MBq and a mean residual activity of 12.63% ± 4.73%. However, variability in residual activity was observed among syringe brands. BD exhibited the highest mean residual activity (16.45%), significantly differing from SJ (9.95%) and Ciringe (11.50%) (P < 0.001). Conclusion: Rigorous syringe selection is crucial in myocardial perfusion imaging procedures to minimize residual activity and ensure compliance with dosimetry standards, emphasizing the importance of integrating pharmacy practices into nuclear medicine protocols. Standardized protocols and quality assurance measures are essential to optimize imaging outcomes and prioritize patient safety. These findings highlight the importance of ongoing monitoring and interdisciplinary collaboration to navigate residual activity management effectively in routine nuclear medicine practice.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"57-62"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Arthrography Improve Accuracy of SPECT/CT for Diagnosis of Aseptic Loosening in Patients with Painful Knee Arthroplasty: A Systematic Review and Metaanalysis. 关节造影是否能提高SPECT/CT诊断膝关节置换术患者疼痛性无菌性松动的准确性：一项系统回顾和荟萃分析

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.123.266050

Charlie Timon, Aoife Feeley, John Mahon, Iain Feeley, John Quinlan, Eoin Sheehan

{"title":"Does Arthrography Improve Accuracy of SPECT/CT for Diagnosis of Aseptic Loosening in Patients with Painful Knee Arthroplasty: A Systematic Review and Metaanalysis.","authors":"Charlie Timon, Aoife Feeley, John Mahon, Iain Feeley, John Quinlan, Eoin Sheehan","doi":"10.2967/jnmt.123.266050","DOIUrl":"10.2967/jnmt.123.266050","url":null,"abstract":"SPECT/CT combines scintigraphy with a CT scan forming a 3-dimensional reconstruction of bone-tracer uptake patterns. It has become a fundamental component of the work-up of a painful total knee arthroplasty (TKA). The addition of an arthrogram is purported to improve its diagnostic yield. The aim of this study was to assess whether the addition of a concurrent arthrogram to a SPECT/CT enhances its sensitivity and specificity for diagnosing aseptic loosening in a painful total knee replacement. Methods: PubMed, Embase, and Scopus were searched in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies compared the results of SPECT/CT with or without an arthrogram against an appropriate reference standard for diagnosing TKA aseptic loosening. The quality of included studies was independently assessed using the QUADAS-2 tool. Results: In total, 160 abstracts were identified by our search strategy. Of these, 6 studies comprising 472 patients met our inclusion criteria. All included studies used operative findings or a period of clinical and radiologic observation as reference standards. The SPECT/CT arthrogram was more sensitive in identifying aseptic loosening of knee prostheses, and it also provided greater specificity for excluding its diagnosis. Conclusion: The amalgamated results of included studies of the use of SPECT/CT demonstrate it is the best test in helping determine aseptic loosening in patients with painful TKAs (specificity, 97% vs. 85%). It is also a more sensitive test (sensitivity, 78% vs. 75%). Considering the potential morbidity of injection of contrast into the prosthetic joint, addition of an arthrogram to SPECT/CT is not beneficial and is potentially harmful.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"44-49"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generative Artificial Intelligence in Nuclear Medicine Education. 核医学教育中的生成式人工智能。

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Journal of nuclear medicine technology Pub Date : 2025-03-05 DOI: 10.2967/jnmt.124.268323

Geoffrey M Currie

{"title":"Generative Artificial Intelligence in Nuclear Medicine Education.","authors":"Geoffrey M Currie","doi":"10.2967/jnmt.124.268323","DOIUrl":"10.2967/jnmt.124.268323","url":null,"abstract":"Generative artificial intelligence (genAI) has become assimilated into the education, research, and clinical domains of nuclear medicine and health care. Understanding the principles, limitations, and applications of genAI is important for capitalizing on its transformative potential in student education and impact on sustainability within both the education and the clinical sectors. In this article, the fundamental principles and applications of artificial intelligence are explored from the context of nuclear medicine. GenAI technologies are defined and capabilities outlined. A detailed investigation of the potential and limitations of both text-to-text and text-to-image genAI based in empiric and anecdotal research is provided. Specific examples of applications of text-to-text and text-to-image genAI are provided. GenAI has the potential to reinvigorate nuclear medicine education by supporting and enriching student learning and to be transformative in nuclear medicine education, but at the time of writing, both text-to-text and text-to-image genAI are far from revolutionary. Nonetheless, the horizon promises transformative education applications of genAI. GenAI can enhance nuclear medicine education and student learning and provide economies to improve sustainability in the education and clinical sectors. Although there are some limitations to current capabilities, this rapidly evolving space will soon offer potential benefits to education.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"72-79"},"PeriodicalIF":1.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turning the Calendar Page to 2025. 把日历翻到2025年。

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Journal of nuclear medicine technology Pub Date : 2025-03-05

Kathy S Thomas

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Can an Abnormal Gastric Emptying Study Be Normal? 胃排空异常能正常吗？

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Journal of nuclear medicine technology Pub Date : 2025-03-04 DOI: 10.2967/jnmt.124.269182

Ben Freiberg

引用次数: 0

Improvement of Anatomic Alignment and Image Quality Using a Respiratory Motion Reduction Block in Oncologic PET/CT. 使用呼吸运动减少块改善肿瘤PET/CT解剖对齐和图像质量。

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Journal of nuclear medicine technology Pub Date : 2025-03-04 DOI: 10.2967/jnmt.124.269096

Hajime Ichikawa, Takayuki Shibutani, Toyohiro Kato, Tomoya Banno, Mitsuaki Terabe, Hideki Shimada

{"title":"Improvement of Anatomic Alignment and Image Quality Using a Respiratory Motion Reduction Block in Oncologic PET/CT.","authors":"Hajime Ichikawa, Takayuki Shibutani, Toyohiro Kato, Tomoya Banno, Mitsuaki Terabe, Hideki Shimada","doi":"10.2967/jnmt.124.269096","DOIUrl":"https://doi.org/10.2967/jnmt.124.269096","url":null,"abstract":"18F-FDG PET/CT is crucial for cancer diagnosis; however, respiratory motion often causes misregistration between PET and CT images. This study aimed to evaluate the impact of a custom-made respiratory motion reduction block (RRB) in reducing misregistration and improving image quality in 18F-FDG PET/CT. Methods: The RRB was developed to minimize the effects of respiratory motion. It is a pentagonal block made of Styrofoam designed to compress the upper abdomen. This study included 170 patients who underwent whole-body 18F-FDG PET/CT. Patients were categorized into 4 groups based on the CT and PET scanning technique used: a control free-breathing (FB) group (breath-holding [BH] CT without RRB and respiration-gated [RG] PET), a control RG group (BH CT without RRB with RG PET), a BH RRB group (BH CT with RRB), and a FB RRB group (FB CT with RRB). Various parameters, including the incidence rate and distance of anatomic misregistration, and signal-to-noise ratio, were measured and compared. Results: For the control FB, control RG, BH RRB, and FB RRB groups, the incidence rates of anatomic misregistration between PET and CT images were 47.1%, 27.5%, 34.0%, and 16.7%, respectively. The mean misregistration distances in these groups were 5.1 ± 6.0, 3.1 ± 5.5, 3.8 ± 6.2, and 1.3 ± 3.2 mm, respectively. Furthermore, the RRB improved the signal-to-noise ratio of the liver. Conclusion: The RRB effectively improved registration between PET and CT images. Our approach is cost-effective and provides respiratory motion suppression not only during PET but also during CT scans. The use of RRB with FB PET scanning was found to be more beneficial than respiratory gating.","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recognizing and Responding to the Acute Cardiac Stress Patient. 认识和应对急性心脏应激病人。

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Journal of nuclear medicine technology Pub Date : 2025-03-04 DOI: 10.2967/jnmt.125.269450

Geoffrey Currie, Hosen Kiat

引用次数: 0