Journal of nuclear medicine technology最新文献

{"title":"Equine Bone Imaging, Part 2: Role of Nuclear Medicine in Racehorses.","authors":"Peter Tually, Geoffrey Currie","doi":"10.2967/jnmt.125.270050","DOIUrl":"10.2967/jnmt.125.270050","url":null,"abstract":"<p><p>The horse racing industry, like any sport, must contend with the effects of injuries on an athlete's performance and longevity. Catastrophic fractures linked to preexisting bone fatigue can be prevented with the use of imaging technology, such as the nuclear medicine bone scan. The accessibility and affordability of imaging for racehorses remain obstacles. The conventional role of bone scintigraphy has evolved with the advent of advanced techniques, including MRI, CT, and PET. Concurrently, SPECT has expanded the role of scintigraphy in the racehorse. This article explores the conventional and contemporary role of bone scintigraphy in the racehorse. Some applications are transferrable to other athletic horses (e.g., equestrian) and stock horses. Nuclear medicine planar and SPECT imaging provide valuable insights into underlying causes of pain or lameness and represent an opportunity to prevent catastrophic injuries. The increasing demand for scintigraphy among racehorses also affords an opportunity for role diversity or alternative career pathways for nuclear medicine scientists and technologists.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"224-229"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Occupational Exposure from ¹⁸F-FDG Injection Procedure Using a Traditional Injection Method Versus an Automated Injection System.","authors":"Raju Gupta, Shantanu Pande, Ashwini P Shinde","doi":"10.2967/jnmt.124.269103","DOIUrl":"10.2967/jnmt.124.269103","url":null,"abstract":"<p><p>We evaluated occupational radiation exposure associated with ¹⁸F-FDG injection using a traditional manual approach versus an automated injection system. <b>Methods:</b> Wrist and whole-body radiation exposure of nuclear medicine personnel using a manual injection method versus an automated injection system for ¹⁸F-FDG administration were assessed using electronic personal dosimeters. Radiation exposure while configuring both systems was also evaluated. The dose administered met the requirements of the \"as low as reasonably achievable\" principle. Radiation exposure during initial setup and dose administration, residual activity, dose accuracy, presence of contamination, and frequency of extravasation were compared between methods. <b>Results:</b> Compared with the traditional manual method, use of the automated injection system resulted in significantly lower mean radiation exposure to medical physicists' wrists (<i>P</i> < 0.01). Radiation exposure was 79.41% lower at the wrist while using the automated injection system. Differences in whole-body radiation exposure were not significant between injection methods (<i>P</i> < 0.56). The overall radiation dose per injection at the wrist and in the whole body and mean residual activity after injection were noticeably lower with the automated system (<i>P</i> < 0.01), with mean residual activity decreasing by 73.58%. <b>Conclusion:</b> The overall radiation exposure for nuclear medicine personnel was significantly decreased when administering ¹⁸F-FDG via an automated injection system.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"257-261"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SNMMI Procedure Standard/EANM Practice Guideline for Radionuclide Brain Perfusion Scintigraphy in Suspected Death by Neurologic Criteria (Brain Death) 3.0.","authors":"Lionel S Zuckier, Matthias Brendel, Diego Cecchin, Kevin Donohoe, Kirk A Frey, Ran Klein, Helen R Nadel, Sam Shemie, Partha Sinha","doi":"10.2967/jnmt.125.270505","DOIUrl":"10.2967/jnmt.125.270505","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"205-214"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nuclear Medicine Technologist Education Landscape According to the Joint Review Committee on Educational Programs in Nuclear Medicine Technology.","authors":"Andrew T Trout, Rodney Fisher, Jim McCumiskey, Jan Winn","doi":"10.2967/jnmt.125.270366","DOIUrl":"10.2967/jnmt.125.270366","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"9A-10A"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with ⁶⁸Ga-FAPI-46 PET/CT.","authors":"Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger","doi":"10.2967/jnmt.125.269645","DOIUrl":"10.2967/jnmt.125.269645","url":null,"abstract":"<p><p>We sought to assess the diagnostic value of ⁶⁸Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). <b>Methods:</b> In this retrospective study, 4 children with a diagnosis of jSSc underwent ⁶⁸Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. <b>Results:</b> In this case series, ⁶⁸Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. <b>Conclusion:</b> ⁶⁸Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using ⁶⁸Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"248-251"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equine Bone Imaging, Part 1: Establishing an Equine Nuclear Medicine Facility.","authors":"Peter Tually, Geoffrey Currie","doi":"10.2967/jnmt.125.270049","DOIUrl":"10.2967/jnmt.125.270049","url":null,"abstract":"<p><p>While the establishment and operation of an equine nuclear medicine department share several principles with those of human nuclear medicine departments, they require an additional skill set to ensure safe and effective operation. This article explores the practical aspects of equine nuclear medicine facility location and design and details important considerations for safe and practical operation. Key considerations associated with the differences in physical and radiation safety and imaging approaches are explored. Specific adaptations of γ-camera gantries to allow either planar imaging or SPECT in a standing horse are described. The skill set and insights of nuclear medicine scientists and technologists are crucial for the safe and effective establishment of an equine nuclear medicine facility.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"218-223"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New School Year, Renewed Educator Energy (Fueled by Caffeine and Curiosity).","authors":"Sarah Frye","doi":"10.2967/jnmt.125.270912","DOIUrl":"https://doi.org/10.2967/jnmt.125.270912","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"53 3","pages":"185-186"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Correlation of Tumor Absorbed Dose with Overall Survival in Metastatic Castration-Resistant Prostate Cancer Treated with ¹⁷⁷Lu Prostate-Specific Membrane Antigen.","authors":"Yung Hsiang Kao","doi":"10.2967/jnmt.125.269658","DOIUrl":"10.2967/jnmt.125.269658","url":null,"abstract":"<p><p>In systemic radiopharmaceutical therapy, a direct dosimetric correlation between the tumor absorbed dose and overall survival, that is, Grays to months, has never been explicitly defined. This dosimetric analysis expounds this relationship in the context of metastatic castration-resistant prostate cancer treated with ¹⁷⁷Lu prostate-specific membrane antigen (¹⁷⁷Lu-PSMA). <b>Methods:</b> The average tumor absorbed dose per unit of administered activity from the first to sixth treatments was extrapolated from population data. This was used to calculate the cumulative tumor absorbed doses above the response threshold for 2 empiric randomized ¹⁷⁷Lu-PSMA clinical trials (VISION and TheraP). This was correlated to the difference in overall survival between these 2 trials to derive the tumor absorbed dose-survival relationship. This result was used to calculate the overall survival for a hypothetical optimized first strike in the context of personalized predictive dosimetry. <b>Results:</b> The tumor absorbed dose-survival relationship is calculated to be approximately 1 mo of overall survival per 1 Gy above the response threshold. An optimized first strike can double the overall survival compared with empiric regimens, delivers a higher cumulative tumor absorbed dose in fewer treatments, and avoids futile whole-body irradiation. Overall survival is proportional to the area bounded by the tumor absorbed dose curve and the response threshold absorbed dose curve. This suggests that, in addition to an optimized first strike, overall survival may also be improved by the concurrent administration of other systemic agents that modify tumor radiobiology to lower the response threshold, such as radiosensitization. <b>Conclusion:</b> Dosimetric evidence advocates for personalized prescription based on predictive dosimetry to optimize overall survival by exploiting radiobiologic synergy between the first strike and tumor radiosensitization.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"252-256"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric-Emptying Pitfalls in Nuclear Medicine.","authors":"Sara G Johnson","doi":"10.2967/jnmt.125.270459","DOIUrl":"10.2967/jnmt.125.270459","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"268-270"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonization of Quantitative Values in Bone SPECT/CT for Medication-Related Osteonecrosis of the Jaw.","authors":"Issei Kuromori, Hiromitsu Daisaki, Yoshiki Owaki, Tatsuya Tsuchitani, Naoya Hayashi, Masakazu Tsujimoto, Yukito Maeda, Naomi Ueno, Yu Iwabuchi, Takashi Norikane, Yoshitaka Inui, Hayato Kaida, Kimiteru Ito, Kazuhiro Kitajima","doi":"10.2967/jnmt.125.269873","DOIUrl":"https://doi.org/10.2967/jnmt.125.269873","url":null,"abstract":"<p><p>The increased use of antiresorptive and antiangiogenic agents in patients with osteoporosis and cancer is closely linked to decreases in quality of life attributable to medication-related osteonecrosis of the jaw (MRONJ), emphasizing the need for accurate diagnosis. Recent advances in quantitative SPECT/CT (Q-SPECT/CT) using bone scintigraphy have enhanced its utility for the early detection and staging of MRONJ. However, the lack of harmonization criteria for SUVs across various scanners hampers multicenter studies. <b>Methods:</b> To address this issue, we conducted a multicenter phantom study to identify harmonization criteria for Q-SPECT/CT in MRONJ and evaluate a software-based harmonization approach. A custom-made brain tumor phantom with 6 hot spheres was filled with a ^99mTc-hydroxymethylene diphosphonate solution (17.5 kBq/mL in the background and 70 kBq/mL in the hot spheres, yielding a hot sphere-to-background ratio of 4). SPECT/CT was performed at 7 institutions using 8 scanners in accordance with clinical protocols. A cylindric phantom was used to calculate the becquerel calibration factor, and a tool for analyzing region of interest and volume of interest was used for SUV conversion, analysis, and harmonization. The harmonization criterion was the median SUV_max ± 30% across scanners. If the SUV_max exceeded this range, then a 3-dimensional gaussian filter was applied. <b>Results:</b> The SUV_mean in the background region remained within 0.95-1.05 (relative to the theoretic value of 1.00) both before and after harmonization, with minimal interscanner differences. Conversely, for the hot spheres, the maximum coefficients of variation for SUV_max, SUV_peak, and SUV_mean improved from 122%, 68%, and 71%, respectively, before harmonization to 48%, 35%, and 37%, respectively, after harmonization. <b>Conclusion:</b> We identified a harmonization criterion for Q-SPECT/CT in MRONJ and demonstrated that our software-based approach effectively reduces interscanner variability without compromising clinical image quality or requiring additional image reconstruction, supporting its utility in multicenter clinical studies.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}