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Optimization of Block Sequential Regularized Expectation Maximization Reconstruction Parameters for Striatal SPECT Using a Ring-Type Semiconductor SPECT/CT System. 基于环形半导体SPECT/CT系统的纹状体SPECT块序贯正则化期望最大化重构参数优化。
IF 1.3
Journal of nuclear medicine technology Pub Date : 2025-08-26 DOI: 10.2967/jnmt.125.269869
Nao Yamaguchi, Hayato Odagiri, Hayato Sato, Hiroyasu Kodama, Yoshitaka Tanaka, Takashi Takeuchi, Kentaro Takanami, Akihito Usui, Tomohiro Kaneta
{"title":"Optimization of Block Sequential Regularized Expectation Maximization Reconstruction Parameters for Striatal SPECT Using a Ring-Type Semiconductor SPECT/CT System.","authors":"Nao Yamaguchi, Hayato Odagiri, Hayato Sato, Hiroyasu Kodama, Yoshitaka Tanaka, Takashi Takeuchi, Kentaro Takanami, Akihito Usui, Tomohiro Kaneta","doi":"10.2967/jnmt.125.269869","DOIUrl":"https://doi.org/10.2967/jnmt.125.269869","url":null,"abstract":"<p><p>This phantom study aimed to optimize the noise-suppression parameter (β) and the edge-preservation parameter (γ) values in the block sequential regularized expectation maximization (BSREM) reconstruction method for <sup>123</sup>I-2-β-carbomethoxy-3β-(4-iodophenyl)-<i>N</i>-(3-fluoropropyl)nortropane striatal SPECT using a ring-type cadmium-zinc-telluride camera. <b>Methods:</b> We used a striatum phantom filled with an <sup>123</sup>I solution, with adjusted concentrations in the left and right caudate and left and right putamen. The phantom was scanned for 120 min using the StarGuide system, and 20-min SPECT data were extracted from the total acquisition. Using the BSREM method, we generated 42 reconstructed images by varying β and γ. We calculated the percent coefficient of variation and percent contrast for each image. Visual evaluations were conducted by a nuclear medicine physician and 2 technologists. Additionally, we calculated the striatal uptake ratio (SUR) and the ratio of the left caudate SUR to putamen SUR in the left striatum (left striatal ratio). <b>Results:</b> The percent coefficient of variation decreased as the β value increased, whereas percent contrast increased as the γ value increased. We conducted a visual evaluation of 15 reconstructed images selected by physical assessment. Images reconstructed with a β value of 0.03 with a γ value of 5 and those with a β value of 0.05 with a γ value of 10 were deemed suitable for diagnostic purposes because of their accurate depiction of tracer accumulation in each striatal region. SUR and left striatal ratio were comparable for these 2 image sets. <b>Conclusion:</b> Evaluation of the optimal conditions for striatal SPECT imaging with BSREM reconstruction revealed that the optimal β value and γ value combinations were a β value of 0.03 and γ value of 5 and a β value of 0.05 and γ value of 10.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appropriate Use Criteria for Molecular Breast Imaging. 乳腺分子成像的适当使用标准。
IF 1.3
Journal of nuclear medicine technology Pub Date : 2025-08-26 DOI: 10.2967/jnmt.125.270865
Elizabeth H Dibble, Sofia Carrilho Vaz, Banu Arun, Amy M Fowler, Lioe-Fee de Geus-Oei, Katie N Hunt, Ravi Jain, Gaiane M Rauch, Mediget Teshome, Matthew F Covington
{"title":"Appropriate Use Criteria for Molecular Breast Imaging.","authors":"Elizabeth H Dibble, Sofia Carrilho Vaz, Banu Arun, Amy M Fowler, Lioe-Fee de Geus-Oei, Katie N Hunt, Ravi Jain, Gaiane M Rauch, Mediget Teshome, Matthew F Covington","doi":"10.2967/jnmt.125.270865","DOIUrl":"https://doi.org/10.2967/jnmt.125.270865","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone SPECT/CT of an Intervertebral Disk Calcification. 椎间盘钙化的骨SPECT/CT表现。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-07-15 DOI: 10.2967/jnmt.124.268823
Muhammad Asad Khan, Humayun Bashir, Adrian Williams
{"title":"Bone SPECT/CT of an Intervertebral Disk Calcification.","authors":"Muhammad Asad Khan, Humayun Bashir, Adrian Williams","doi":"10.2967/jnmt.124.268823","DOIUrl":"https://doi.org/10.2967/jnmt.124.268823","url":null,"abstract":"<p><p>Calcific diskitis (CD) is a rare condition characterized by inflammation and calcification of an intervertebral disk, typically causing localized back pain. We present the case of a 65-y-old woman with a history of breast cancer and persistent back pain. SPECT/CT identified focal uptake at the T10-T11 vertebrae, localized to the intervertebral disk. Retrospective review of MR images from 2016 demonstrated a hypointense signal within the same disk on both T1- and T2-weighted images, consistent with disk calcification. This case highlights the utility of SPECT/CT in identifying CD and distinguishing it from other pathologies, including metastatic or degenerative spinal disease. CD should be considered in the differential diagnoses of backache.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[18F]FDG PET/CT in a Rare Case of Pancreatic Ewing Sarcoma. [18]胰腺尤因肉瘤的FDG PET/CT分析。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-07-15 DOI: 10.2967/jnmt.124.269246
Yamini Dharmashaktu, Shamim A Shamim, Sameer Rastogi, Ritwik Wakankar, Sushant Chib
{"title":"[<sup>18</sup>F]FDG PET/CT in a Rare Case of Pancreatic Ewing Sarcoma.","authors":"Yamini Dharmashaktu, Shamim A Shamim, Sameer Rastogi, Ritwik Wakankar, Sushant Chib","doi":"10.2967/jnmt.124.269246","DOIUrl":"https://doi.org/10.2967/jnmt.124.269246","url":null,"abstract":"<p><p>Extraosseous Ewing sarcoma (EES) is a rare malignant tumor originating from soft tissue, comprising approximately 20% of all Ewing sarcoma cases. EES commonly involves the trunk or extremities, with pancreatic involvement being extremely uncommon. Because of its rarity, EES of the pancreas may be misdiagnosed initially and requires a multimodality approach. We present the case of a 25-y-old woman who was initially treated for acute pancreatitis. However, her symptoms persisted, and a [<sup>18</sup>F]FDG PET/CT was conducted for evaluation, the results of which suggested malignancy, which was later confirmed on biopsy as EES of the pancreas.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prominent Right Ventricular Tracer Uptake: A Harbinger of Multivessel Coronary Artery Disease. 右心室示踪剂摄取突出：多支冠状动脉疾病的先兆。
IF 1.3
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.125.270002
Adam Adam, Saurabh Malhotra
{"title":"Prominent Right Ventricular Tracer Uptake: A Harbinger of Multivessel Coronary Artery Disease.","authors":"Adam Adam, Saurabh Malhotra","doi":"10.2967/jnmt.125.270002","DOIUrl":"10.2967/jnmt.125.270002","url":null,"abstract":"<p><p>A 65-y-old woman with multiple cardiovascular risk factors presented with atypical chest pain, prompting a 1-d pharmacologic stress myocardial perfusion test using <sup>99m</sup>Tc sestamibi. Initial interpretation suggested ischemia, but closer inspection revealed increased right ventricular uptake and increased left ventricular chamber size at stress, indicative of significant 3-vessel coronary artery disease (CAD). These findings were confirmed by cardiac catheterization, showing 3-vessel disease, including significant left main CAD. The patient underwent coronary artery bypass graft surgery. This case highlights the importance of meticulous SPECT image interpretation, particularly focusing on right ventricular uptake and transient ischemic dilation, to accurately diagnose severe CAD and improve cardiovascular outcomes.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"172-173"},"PeriodicalIF":1.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung Ventilation: Technegas. 肺通气：tecnegas。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.125.269769
Tina M Buehner
{"title":"Lung Ventilation: Technegas.","authors":"Tina M Buehner","doi":"10.2967/jnmt.125.269769","DOIUrl":"10.2967/jnmt.125.269769","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"183"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase I Study of 68Ga-NOTA-HL for PET/CT Imaging of Hepatic Asialoglycoprotein Receptors in Healthy Volunteers. 68Ga-NOTA-HL用于健康志愿者肝亚糖糖蛋白受体PET/CT成像的一期研究。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.124.268430
Ching-Liang Kuo, Rhoh-Fang Yen, Yao-Ming Wu, Mei-Hui Wang
{"title":"Phase I Study of <sup>68</sup>Ga-NOTA-HL for PET/CT Imaging of Hepatic Asialoglycoprotein Receptors in Healthy Volunteers.","authors":"Ching-Liang Kuo, Rhoh-Fang Yen, Yao-Ming Wu, Mei-Hui Wang","doi":"10.2967/jnmt.124.268430","DOIUrl":"10.2967/jnmt.124.268430","url":null,"abstract":"<p><p>This study investigated the safety, biodistribution, and dosimetry of <sup>68</sup>Ga-hexavalent lactoside (<sup>68</sup>Ga-NOTA-HL), a PET tracer targeting asialoglycoprotein receptors (ASGPRs) on hepatocytes. ASGPRs, key for glycoprotein homeostasis, serve as a valuable biomarker of liver function. <sup>68</sup>Ga-NOTA-HL demonstrated excellent safety in 12 healthy volunteers with no adverse events. Biodistribution studies revealed high liver uptake with minimal uptake in other organs, consistent with ASGPR targeting. The effective dose was 0.0289 mSv/MBq, indicating low radiation exposure. These findings suggest <sup>68</sup>Ga-NOTA-HL PET/CT holds significant promise as a safe and effective imaging technique for assessing liver function. The high liver specificity and extremely low background activity provide a strong foundation for further clinical investigations into its potential for evaluating liver function in various clinical settings, including the assessment of liver reserve in patients with liver diseases.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"152-157"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPECT/CT for Discrimination Between Active and Inactive Os Trigonum in Posterior Ankle Syndrome. 后踝关节综合征中活跃与不活跃三角肌的SPECT/CT鉴别。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.124.269284
Michael Pöhlmann, Martin Freesmeyer, Falk Gühne
{"title":"SPECT/CT for Discrimination Between Active and Inactive Os Trigonum in Posterior Ankle Syndrome.","authors":"Michael Pöhlmann, Martin Freesmeyer, Falk Gühne","doi":"10.2967/jnmt.124.269284","DOIUrl":"10.2967/jnmt.124.269284","url":null,"abstract":"<p><p>[<sup>99m</sup>Tc]-3,3-diphosphono-1,2-propanodicarboxylic acid bone scintigraphy was used to differentiate between posterior impingement syndrome and Haglund syndrome in a 34-y-old man with unclear right-sided ankle pain. The patient had an accessory os trigonum bilaterally, and previous x-ray, MRI, and CT were inconclusive. Using SPECT/CT with new iterative reconstruction algorithms based on CT images, the pathologic activation of bone metabolism at the right-sided os trigonum and the adjacent talus joint was revealed. Other causes of posterior ankle pain were ruled out, and posterior impingement syndrome was diagnosed.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"178-179"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Mimicker in Thyroid Cancer with Thyroglobulin Elevation and an FDG-Avid Recurrent Aneurysmal Bone Cyst. 甲状腺癌伴甲状腺球蛋白升高和fdg复发性动脉瘤性骨囊肿的转移模拟因子。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.124.269415
Piyush Aggarwal, Yamini Mathur, Ashwani Sood, Rajender Kumar, Bhagwant Rai Mittal
{"title":"Metastatic Mimicker in Thyroid Cancer with Thyroglobulin Elevation and an FDG-Avid Recurrent Aneurysmal Bone Cyst.","authors":"Piyush Aggarwal, Yamini Mathur, Ashwani Sood, Rajender Kumar, Bhagwant Rai Mittal","doi":"10.2967/jnmt.124.269415","DOIUrl":"10.2967/jnmt.124.269415","url":null,"abstract":"<p><p>Many benign bone lesions mimic skeletal metastases from thyroid cancer on imaging and even may have high metabolic uptake on <sup>18</sup>F-FDG PET/CT. It becomes crucial to distinguish these hypermetabolic lesions (benign vs. metastasis), especially in patients with thyroglobulin elevation and negative iodine scan. The index case describes a patient with thyroid cancer having thyroglobulin elevation and negative iodine scan with a hypermetabolic aneurysmal bone cyst mimicking skeletal metastasis.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"176-177"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Sarcoidosis Imaging: PET. 心脏结节病影像学：PET。
IF 1
Journal of nuclear medicine technology Pub Date : 2025-06-04 DOI: 10.2967/jnmt.125.269838
Diane K Soulek, Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle
{"title":"Cardiac Sarcoidosis Imaging: PET.","authors":"Diane K Soulek, Mary Beth Farrell, Kathy S Thomas, Eleanor S Mantel, Jessica Settle","doi":"10.2967/jnmt.125.269838","DOIUrl":"10.2967/jnmt.125.269838","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"113-115"},"PeriodicalIF":1.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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