Journal of nuclear medicine technology最新文献

{"title":"Imaging Features That Predict Indeterminate Bone Lesion Outcomes on ¹⁸F-DCFPyL PSMA PET/CT Scan: A Multicenter Cohort of 42 Biopsy-Proven Lesions.","authors":"Matthew S Agritelley, Bifei Hao, Seth Hill, Bo Zhou, Logan Linscheid, Scott Leonard, Hatice Savas, Ryan J Avery","doi":"10.2967/jnmt.125.271409","DOIUrl":"10.2967/jnmt.125.271409","url":null,"abstract":"<p><p>Indeterminate bone lesions (IBLs) on prostate-specific membrane antigen (PSMA) PET/CT are common and pose a diagnostic dilemma with important management implications. There is currently no clear consensus on imaging features that predict lesion outcomes. Our study aimed to identify features that characterize IBLs as benign or malignant on ¹⁸F-DCFPyL PSMA PET/CT using only biopsy-proven lesions. <b>Methods:</b> In total, 42 IBLs (21 biopsy-proven metastatic prostate cancer and 21 biopsy-proven benign) with pathologic diagnosis obtained at a median of 24 d after ¹⁸F-DCFPyL PET/CT imaging were retrospectively identified. Postprocessing software provided SUV measurements for IBLs and background liver/parotid gland ratios. Variables were analyzed using Firth and conventional logistic regression along with random forest with leave-one-out cross-validation models. <b>Results:</b> Threshold values for malignancy of IBL SUV_max of 8 or greater, IBL/liver SUV_max ratio of 1 or greater, IBL/parotid gland SUV_max ratio of 0.3 or greater, and PROMISE V2 score of 2 or 3 were all predictors of lesion malignancy with accuracy between 86% (36/42) and 88% (37/42) (all <i>P</i> < 0.0001). The presence of multiple bone lesions (<i>P</i> < 0.0001) and clinical status of biochemical recurrence (<i>P</i> = 0.002) were predictive of malignancy, whereas non-biochemical recurrence disease status (<i>P</i> = 0.008) was predictive of benignity. Lesion location and prostate-specific antigen level were not predictive of lesion outcome. <b>Conclusion:</b> IBL SUV and the ratios of IBL to background liver or parotid gland uptake are quantitative metrics that help predict whether a lesion is benign or malignant, irrespective of prostate-specific antigen level or lesion location. Because of the ease of applicability, we highlight IBL SUV_max of 8 or greater and IBL/liver SUV_max ratios of 1 or greater as predictors of lesion malignancy and an SUV_max of less than 8 and IBL/liver SUV_max ratio of less than 1 as predictors of lesion benignity. These metrics can and should be used in conjunction with a PROMISE V2 score to help stratify lesions as benign or malignant.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"309-317"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"54 3","pages":"328"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparing for Practice, Part 1: Clinical Partner Perspectives on Entry-Level Competency in Radiopharmaceutical Therapy-A Program Improvement Initiative.","authors":"Julie Bolin, Melanie Pietryka","doi":"10.2967/jnmt.126.272917","DOIUrl":"10.2967/jnmt.126.272917","url":null,"abstract":"<p><p>The rapid expansion of radiopharmaceutical therapy and theranostics has introduced new expectations for nuclear medicine technologists and created ongoing challenges for educational programs preparing students for this evolving field. Variability in clinical exposure and institutional resources has made it difficult to define what constitutes appropriate entry-level competency versus skills that should be developed through structured clinical onboarding. GateWay Community College's nuclear medicine technology program undertook a program improvement initiative to better align curriculum with regional clinical expectations. Outreach was conducted to clinical preceptors, affiliate education supervisors, nuclear medicine managers, and a physician assistant with nuclear medicine technologist experience, representing affiliated sites that include community hospitals, large academic medical centers, a comprehensive cancer center, and institutions with active ⁹⁰Y-radioembolization and interventional radiology-integrated therapy programs. Convergent themes across respondents revealed a consistent distinction between foundational competencies expected at graduation and procedural skills appropriately developed after entry into practice. Several themes emerged that extend beyond the scope of traditional nuclear medicine curricula: the structural barriers limiting student access to theranostics, specific skill gaps most commonly observed in students and new graduates, the NMT's emerging role as an interdisciplinary radiation safety educator, and the growing importance of postinfusion imaging and dosimetry as future technologist competencies. Vendor-provided training was identified as insufficient to develop the broader clinical reasoning required for safe, independent practice. Part 2 of this series describes the simulation-based curriculum framework developed in response to these findings.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"245-251"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary Flat Bone Metastasis of Follicular Thyroid Carcinoma: Complete Molecular and Partial Structural Response After 2 ¹³¹I Therapies.","authors":"Rangat Bagasariya, Priyanka Verma, Sandip Basu","doi":"10.2967/jnmt.125.271417","DOIUrl":"10.2967/jnmt.125.271417","url":null,"abstract":"<p><p>We report a case of follicular thyroid carcinoma presenting with a solitary skeletal metastasis in right iliac bone that remained structurally persistent after 2 high-dose ¹³¹I treatments. However, the lesion showed no uptake on [¹⁸F]FDG PET/CT, ¹³¹I scintigraphy, or [⁶⁸Ga]Ga-FAPI PET/CT, suggesting the absence of metabolic or receptor activity. This discordance between anatomic persistence and lack of molecular expression highlights the potential of molecular imaging to detect early treatment response, even when the lesion is structurally persistent. This case highlights the importance of integrating molecular imaging into treatment response evaluation to better assess disease activity and guide further management in differentiated thyroid carcinoma.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"326-328"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation-Enhanced Learning in Nuclear Medicine: Practical-Use SCAFFOLD.","authors":"Geoffrey M Currie, Johnathan Hewis, Kym Barry, Tarni Nelson, David Gilmore","doi":"10.2967/jnmt.126.272439","DOIUrl":"10.2967/jnmt.126.272439","url":null,"abstract":"<p><p>Simulation-based education has emerged as a strategic response to placement scarcity, workforce strain, and the increasing complexity of nuclear medicine practice. The theoretic principles and simulation architecture are transformed into practical implementation strategies across the nuclear medicine technologist training continuum. Simulation is positioned as a calibrated scaffold that reduces cognitive load, enhances safety, and strengthens readiness for authentic clinical engagement. A broad spectrum of simulation modalities are explored, including task trainers, human actor simulation, laboratory rehearsal, computer-based console simulators, immersive virtual and augmented realities, metaverse environments, synthetic data generation, artificial intelligence-enhanced adaptive simulation, and in situ departmental integration. Enrichment tools are presented as amplifiers that enhance feedback, fidelity, and personalization. Through applied case examples and reflective practice insights, simulation is conceptualized as a staged developmental framework aligned with regulatory expectations and workforce realities. The proposed SCAFFOLD (Simulation as a Calibrated Framework for Optimizing Learning and Development) framework offers a pragmatic blueprint for enhancing work-integrated learning readiness while preserving the irreplaceable value of authentic clinical experience.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"271-280"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Empowered Nuclear Medicine Education, Part 1: Theoretical and Ethical Foundation.","authors":"Keith M Jacobs, Justin G Peacock","doi":"10.2967/jnmt.126.273207","DOIUrl":"10.2967/jnmt.126.273207","url":null,"abstract":"<p><p>Nuclear medicine (NM) is rapidly expanding with new radiopharmaceuticals, imaging equipment, and theranostic possibilities, necessitating a capable and competent workforce expansion. Consequently, NM education must undergo a transformation, powered in part by artificial intelligence (AI). AI is rapidly entering NM education through learner study materials, assessment design, simulation, feedback, and administrative workflows. AI's value depends less on tool novelty than on ethical alignment with effective learning principles. NM educators and trainees need practical approaches for AI tool use that preserve human judgment, accountability, critical thought, creativity, privacy, and source verification. As the first article in a 3-part series on AI-empowered NM education, this practical guide summarizes and integrates selected literature from AI in health professions education, NM education, learning theories, and ethics. Building on a framework of established learning theories (transformative learning, self-regulated learning, experiential learning, connectivism, constructivism, and cognitive load theory) and ethical concerns about AI (e.g., accuracy, bias, transparency, privacy), we describe effective AI techniques (structured prompt design, retrieval-augmented generation, meta-prompting, AI customization, vibe coding) that can be applied for the NM educator and learner in parts 2 and 3 of the series, respectively. These benefits require explicit safeguards, including AI guardrail incorporation, privacy protection, expert review, AI output transparency, and healthy skepticism. AI should be integrated into NM education through theory-informed, source-grounded, and expert-reviewed workflows. Meeting the demands of increased NM volumes and expanded professional opportunities will require AI-empowered educators and trainees that are able to self-regulate and transform their learning through healthy patterns of human-AI interaction.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"221-227"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparing for Practice, Part 2: A Simulation-Based Curriculum Framework for Radiopharmaceutical Therapy Education-A Program Improvement Initiative.","authors":"Julie Dawn Bolin","doi":"10.2967/jnmt.126.272918","DOIUrl":"10.2967/jnmt.126.272918","url":null,"abstract":"<p><p>GateWay Community College's Bachelor of Applied Science in Nuclear Medicine Technology and Computed Tomography program developed a simulation-based curriculum framework in response to clinical partner feedback on entry-level preparation gaps in radiopharmaceutical therapy. Part 1 of this series described the outreach process and the themes that emerged from the 6 respondents, drawn from 9 individuals contacted across 8 affiliated clinical sites, including clinical preceptors, affiliate education supervisors, nuclear medicine managers, and a physician assistant contributor. The present article describes the curriculum response to those findings. Four structured simulation activities are presented, progressing from workflow planning and patient communication through integrated therapy day management. Each simulation is grounded in protocol-specific clinical details derived from the [¹⁷⁷Lu]Lu-DOTATATE (Lutathera) prescribing information and the Novartis RLT Institute administration protocols and is aligned with the Society of Nuclear Medicine and Molecular Imaging Technologist Section Radiopharmaceutical Therapy Intensive Competencies. The framework addresses the specific skill gaps identified by clinical partners, including errors in radiation measurement recording and survey technique, and incorporates the underrecognized role of the nuclear medicine technologist as an active radiation safety educator in interdisciplinary therapy environments. Guidance for hybrid and online delivery is included. Companion supplemental materials provide complete simulation scenarios, checklists, rubrics, and administration method reference materials.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":"252-259"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition and Opportunity: Shaping the Future Together.","authors":"Shannon Youngblood","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":"54 3","pages":"7A-8A"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Exposure from Patients During ¹⁷⁷Lu-DOTATATE Infusions.","authors":"Sameer V Tipnis, William J Rieter","doi":"10.2967/jnmt.126.272633","DOIUrl":"https://doi.org/10.2967/jnmt.126.272633","url":null,"abstract":"<p><p>The quantification of radiation exposure to medical staff and the public during the infusion of radiotherapies is vital to the development of safe workplace practices and the release of patients after the procedure. <b>Methods:</b> We report the measured radiation exposures on contact with the patient along the anterior abdomen, at the armrest on the noninfusion side (approximately 0.2 m from the patient), and at 1 m from the patient over the course of 10 infusions of 7.4 GBq (200 mCi) of ¹⁷⁷Lu-DOTATATE. <b>Results:</b> The mean exposure rates on contact and at 1 m were 12.2 ± 4.9 and 1.6 ± 1.0 mrem/h, respectively. The mean cumulative radiation exposures at patient contact and at the armrest were 133.8 ± 19.3 and 39.4 ± 10.1 mrem, respectively. <b>Conclusion:</b> Our results show the exposures throughout the course of treatment are well below the Nuclear Regulatory Commission release criteria of 500 mrem. Thus, patients pose little risk in terms of radiation safety to staff and the public during and after their infusions.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Pitfall of ¹⁸F-FDG PET/CT: Unifocal Nonbacterial Osteomyelitis Mimicking Bone Metastasis.","authors":"Mürsel Daşar, Aylin Akbulut, Koray Demirel, Gökhan Koca, Meliha Korkmaz","doi":"10.2967/jnmt.126.272461","DOIUrl":"https://doi.org/10.2967/jnmt.126.272461","url":null,"abstract":"<p><p>Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory bone disorder of unclear etiology that may present with unifocal or multifocal lesions. Because it can mimic malignancy on imaging, clinicoradiologic correlation and a multidisciplinary approach are essential. We report unifocal inflammatory osteitis compatible with CNO involving the sternum in a 56-y-old woman with a history of ductal carcinoma in situ. During surveillance, bone scintigraphy showed focal ^99mTc-methylene diphosphonate uptake and ¹⁸F-FDG PET/CT revealed a solitary ¹⁸F-FDG-avid sternal lesion. MRI findings were suggestive of osteomyelitis. Biopsy excluded malignancy, supporting a diagnosis of CNO. Follow-up MRI demonstrated regression. This case underscores that a solitary ¹⁸F-FDG-avid sternal lesion does not necessarily represent metastatic disease, and histopathologic confirmation may prevent unnecessary treatment escalation.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}