Journal of Neuroscience Research最新文献_第8页

Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal CA1 neurons of rats 产前通过母体注射皮质酮会延迟大鼠海马 CA1 神经元突触后的发育，从而诱发学习和记忆障碍。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-30 DOI: 10.1002/jnr.25323

Hye-Ji Kim, Eun-A Ko, Oh-Bin Kwon, Sung-Cherl Jung

{"title":"Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal CA1 neurons of rats","authors":"Hye-Ji Kim, Eun-A Ko, Oh-Bin Kwon, Sung-Cherl Jung","doi":"10.1002/jnr.25323","DOIUrl":"10.1002/jnr.25323","url":null,"abstract":"Previously, we reported that prenatal exposure to high corticosterone induced attention-deficit hyperactivity disorder (ADHD)-like behaviors with cognitive deficits after weaning. In the present study, cellular mechanisms underlying cortisol-induced cognitive dysfunction were investigated using rat pups (Corti.Pups) born from rat mothers that were repetitively injected with corticosterone during pregnancy. In results, Corti.Pups exhibited the failure of behavioral memory formation in the Morris water maze (MWM) test and the incomplete long-term potentiation (LTP) of hippocampal CA1 neurons. Additionally, glutamatergic excitatory postsynaptic currents (EPSCs) were remarkably suppressed in Corti.Pups compared to normal rat pups. Incomplete LTP and weaker EPSCs in Corti.Pups were attributed to the delayed postsynaptic development of CA1 neurons, showing a higher expression of NR2B subunits and lower expression of PSD-95 and BDNF. These results indicated that the prenatal treatment with corticosterone to elevate cortisol level might potently downregulate the BDNF-mediated signaling critical for the synaptic development of hippocampal CA1 neurons during brain development, and subsequently, induce learning and memory impairment. Our findings suggest a possibility that the prenatal dysregulation of cortisol triggers the epigenetic pathogenesis of neurodevelopmental psychiatric disorders, such as ADHD and autism.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of orexin in Parkinson's disease 奥曲肽在帕金森病中的作用

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-23 DOI: 10.1002/jnr.25322

Alisha Braun, Jim Manavis, Akihiro Yamanaka, Youichirou Ootsuka, Peter Blumbergs, Larisa Bobrovskaya

{"title":"The role of orexin in Parkinson's disease","authors":"Alisha Braun, Jim Manavis, Akihiro Yamanaka, Youichirou Ootsuka, Peter Blumbergs, Larisa Bobrovskaya","doi":"10.1002/jnr.25322","DOIUrl":"https://doi.org/10.1002/jnr.25322","url":null,"abstract":"Emerging evidence has implicated the orexin system in non-motor pathogenesis of Parkinson's disease. It has also been suggested the orexin system is involved in the modulation of motor control, further implicating the orexin system in Parkinson's disease. Parkinson's disease is the second most common neurodegenerative disease with millions of people suffering worldwide with motor and non-motor symptoms, significantly affecting their quality of life. Treatments are based solely on symptomatic management and no cure currently exists. The orexin system has the potential to be a treatment target in Parkinson's disease, particularly in the non-motor stage. In this review, the most current evidence on the orexin system in Parkinson's disease and its potential role in motor and non-motor symptoms of the disease is summarized. This review begins with a brief overview of Parkinson's disease, animal models of the disease, and the orexin system. This leads into discussion of the possible roles of orexin neurons in Parkinson's disease and levels of orexin in the cerebral spinal fluid and plasma in Parkinson's disease and animal models of the disease. The role of orexin is then discussed in relation to symptoms of the disease including motor control, sleep, cognitive impairment, psychological behaviors, and the gastrointestinal system. The neuroprotective effects of orexin are also summarized in preclinical models of the disease.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote ischemic conditioning improves cerebral hemodynamics in symptomatic intracranial atherosclerosis: A PET/CT-guided randomized controlled study 远程缺血调理可改善无症状颅内动脉粥样硬化患者的脑血流动力学：PET/CT 引导的随机对照研究。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-22 DOI: 10.1002/jnr.25324

Hong An, Hongrui Ma, Chuanjie Wu, Chunlei Cui, Longfei Wu, Wenbo Zhao, Bixiao Cui, Sijie Li, Di Wu, Wenli Hu, Xunming Ji

{"title":"Remote ischemic conditioning improves cerebral hemodynamics in symptomatic intracranial atherosclerosis: A PET/CT-guided randomized controlled study","authors":"Hong An, Hongrui Ma, Chuanjie Wu, Chunlei Cui, Longfei Wu, Wenbo Zhao, Bixiao Cui, Sijie Li, Di Wu, Wenli Hu, Xunming Ji","doi":"10.1002/jnr.25324","DOIUrl":"10.1002/jnr.25324","url":null,"abstract":"Patients with symptomatic intracranial arterial stenosis (sICAS) suffer embarrassed hemodynamic status and acute ischemic stroke (AIS) recurrence. We aimed to assess the efficacy of remote ischemic conditioning (RIC) on improving this status by evaluating cerebral blood flow (CBF) and cerebral glucose metabolism (CGM) via PET/CT. Adult patients with unilateral sICAS in middle cerebral artery and/or intracranial segment of internal carotid artery-related AIS or transient ischemic attack within 6 months prior to randomization were enrolled. Individuals who received intravenous thrombolysis or endovascular treatment, or sICAS caused by cardiac embolism, small vessel occlusion, or other determined causes were excluded. Twenty-three eligible patients were randomly assigned to standard medical treatment (SMT) (n = 10) or RIC group (n = 13). The RIC protocol consisted of 5 cycles, each for 5-min bilateral upper limb ischemia and 5-min reperfusion period, twice a day, with a total duration of 3 months. Ten healthy volunteers were enrolled as healthy control group. We tested CBF and CGM at the rest stage and the methazolamide-induced stress stage. All patients received PET/CT at baseline and three-month followup. Both CBF and CGM in ipsilateral hemisphere of sICAS patients were significantly decreased at the rest stage and the stress stage (p < .05), which were improved by three-month RIC (p < .05). The lesions decreased notably in RIC group compared to SMT group (p < .05). RIC ameliorated the hemodynamic status and glucose metabolism in regions at high risk of infarction, which might improve the resistance capacity towards ischemic load in sICAS patients.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice 雄性 APP/PS1 小鼠早期淀粉样蛋白诱导的小胶质细胞基因表达变化。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-21 DOI: 10.1002/jnr.25295

Takuya Oshima, Mandy S. J. Kater, Christiaan F. M. Huffels, Evelyn M. Wesseling, Jinte Middeldorp, Elly M. Hol, Mark H. G. Verheijen, August B. Smit, Erik W. G. M. Boddeke, Bart J. L. Eggen

{"title":"Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice","authors":"Takuya Oshima, Mandy S. J. Kater, Christiaan F. M. Huffels, Evelyn M. Wesseling, Jinte Middeldorp, Elly M. Hol, Mark H. G. Verheijen, August B. Smit, Erik W. G. M. Boddeke, Bart J. L. Eggen","doi":"10.1002/jnr.25295","DOIUrl":"10.1002/jnr.25295","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau. Many AD risk genes, identified in genome-wide association studies (GWAS), are expressed in microglia, the innate immune cells of the central nervous system. Specific subtypes of microglia emerged in relation to AD pathology, such as disease-associated microglia (DAMs), which increased in number with age in amyloid mouse models and in human AD cases. However, the initial transcriptional changes in these microglia in response to amyloid are still unknown. Here, to determine early changes in microglia gene expression, hippocampal microglia from male APPswe/PS1dE9 (APP/PS1) mice and wild-type littermates were isolated and analyzed by RNA sequencing (RNA-seq). By bulk RNA-seq, transcriptomic changes were detected in hippocampal microglia from 6-months-old APP/PS1 mice. By performing single-cell RNA-seq of CD11c-positive and negative microglia from 6-months-old APP/PS1 mice and analysis of the transcriptional trajectory from homeostatic to CD11c-positive microglia, we identified a set of genes that potentially reflect the initial response of microglia to Aβ.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antagonism of metabotropic glutamate receptor type 5 prevents levodopa-induced dyskinesia development in a male rat model of Parkinson's disease: Electrophysiological evidence 拮抗代谢型谷氨酸受体 5 型可预防左旋多巴诱导的帕金森病雄性大鼠模型运动障碍的发展：电生理学证据

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-21 DOI: 10.1002/jnr.25302

Hikaru Kamo, Hirokazu Iwamuro, Ryota Nakamura, Shuko Nojiri, Ayami Okuzumi, Takashi Ogawa, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo

{"title":"Antagonism of metabotropic glutamate receptor type 5 prevents levodopa-induced dyskinesia development in a male rat model of Parkinson's disease: Electrophysiological evidence","authors":"Hikaru Kamo, Hirokazu Iwamuro, Ryota Nakamura, Shuko Nojiri, Ayami Okuzumi, Takashi Ogawa, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo","doi":"10.1002/jnr.25302","DOIUrl":"10.1002/jnr.25302","url":null,"abstract":"Levodopa-induced dyskinesia (LID) is a common complication in patients with advanced Parkinson's disease (PD) undergoing treatment with levodopa. Glutamate receptor antagonists can suppress LID; however, the underlying mechanisms remain unclear. Here, we aimed to evaluate the effect of 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP), a metabotropic glutamate receptor 5 (mGluR5) antagonist, on dyskinesia. We recorded the neuronal activity of the entopeduncular nucleus and examined responses to cortical electric stimulation in the control group (n = 6) and three groups of rats (male PD model). Saline was intraperitoneally administered to dopamine lesioned (DL) rats (n = 6), levodopa/benserazide (L/B) was administered to LID rats (n = 8), and L/B combined with MTEP was administered to MTEP rats (n = 6) twice daily for 14 days. We administered L/B to LID and MTEP rats 48 h after the final administration of MTEP to examine the chronic effect of MTEP. The control and DL groups did not have LID. The MTEP group had less LID than the LID group (p < .01) on day 1 and day 18. The control group had a typical triphasic pattern consisting of early excitation (early-Ex), inhibition, and late excitation (late-Ex). However, the inhibition phase disappeared, was partially observed, and was fully suppressed in the DL, LID, and MTEP groups, respectively. The cortico-striato-entopeduncular pathway is important in the pathophysiology of LID. mGluR5 antagonism suppresses LID progression by preventing physiological changes in the cortico-striato-entopeduncular pathway. Future studies are required to validate these results.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large nesting expression in deer mice remains stable under conditions of visual deprivation despite heightened limbic involvement: Perspectives on compulsive-like behavior 鹿小鼠的大嵌套表达在视觉剥夺条件下保持稳定，尽管边缘系统的参与程度有所提高：强迫行为的前景

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-21 DOI: 10.1002/jnr.25320

Harry Marx, Thomas E. Krahe, De Wet Wolmarans

{"title":"Large nesting expression in deer mice remains stable under conditions of visual deprivation despite heightened limbic involvement: Perspectives on compulsive-like behavior","authors":"Harry Marx, Thomas E. Krahe, De Wet Wolmarans","doi":"10.1002/jnr.25320","DOIUrl":"10.1002/jnr.25320","url":null,"abstract":"Visual stimuli and limbic activation varyingly influence obsessive-compulsive symptom expression and so impact treatment outcomes. Some symptom phenotypes, for example, covert repugnant thoughts, are likely less sensitive to sensory stimuli compared to symptoms with an extrinsic focus, that is, symptoms related to contamination, safety, and “just-right-perceptions.” Toward an improved understanding of the neurocognitive underpinnings of obsessive-compulsive psychobiology, work in naturalistic animal model systems is useful. Here, we explored the impact of visual feedback and limbic processes on 24 normal (NNB) and large (LNB) nesting deer mice, respectively (as far as possible, equally distributed between sexes). Briefly, after behavioral classification into either the NNB or LNB cohorts, mice of each cohort were separated into two groups each and assessed for nesting expression under either standard light conditions or conditions of complete visual deprivation (VD). Nesting outcomes were assessed in terms of size and neatness. After nesting assessment completion, mice were euthanized, and samples of frontal-cortical and hippocampal tissues were collected to determine serotonin and noradrenaline concentrations. Our results show that LNB, as opposed to NNB, represents an inflexible and excessive behavioral phenotype that is not dependent on visually guided action-outcome processing, and that it associates with increased frontal-cortical and hippocampal noradrenaline concentrations, irrespective of lighting condition. Collectively, the current results are informing of the neurocognitive underpinnings of nesting behavior. It also provides a valuable foundation for continued investigations into the noradrenergic mechanisms that may influence the development and promulgation of excessive, rigid, and inflexible behaviors.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations 基底前脑向杏仁核基底外侧投射的功能神经解剖学：递质、受体和神经元亚群

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-16 DOI: 10.1002/jnr.25318

Alexander Joseph McDonald

{"title":"Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations","authors":"Alexander Joseph McDonald","doi":"10.1002/jnr.25318","DOIUrl":"https://doi.org/10.1002/jnr.25318","url":null,"abstract":"The projections of the basal forebrain (BF) to the hippocampus and neocortex have been extensively studied and shown to be important for higher cognitive functions, including attention, learning, and memory. Much less is known about the BF projections to the basolateral nuclear complex of the amygdala (BNC), although the cholinergic innervation of this region by the BF is actually far more robust than that of cortical areas. This review will focus on light and electron microscopic tract-tracing and immunohistochemical (IHC) studies, many of which were published in the last decade, that have analyzed the relationship of BF inputs and their receptors to specific neuronal subtypes in the BNC in order to better understand the anatomical substrates of BF-BNC circuitry. The results indicate that BF inputs to the BNC mainly target the basolateral nucleus of the BNC (BL) and arise from cholinergic, GABAergic, and perhaps glutamatergic BF neurons. Cholinergic inputs mainly target dendrites and spines of pyramidal neurons (PNs) that express muscarinic receptors (MRs). MRs are also expressed by cholinergic axons, as well as cortical and thalamic axons that synapse with PN dendrites and spines. BF GABAergic axons to the BL also express MRs and mainly target BL interneurons that contain parvalbumin. It is suggested that BF-BL circuitry could be very important for generating rhythmic oscillations known to be critical for emotional learning. BF cholinergic inputs to the BNC might also contribute to memory formation by activating M1 receptors located on PN dendritic shafts and spines that also express NMDA receptors.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140139212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant- and anxiolytic-like effects in female rats 重复服用非那雄胺可促进突触可塑性，并对雌性大鼠产生抗抑郁和抗焦虑作用。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-12 DOI: 10.1002/jnr.25306

Jose Nayana, Byrathnahalli S. Shankaranarayana Rao, Bettadapura N. Srikumar

{"title":"Repeated finasteride administration promotes synaptic plasticity and produces antidepressant- and anxiolytic-like effects in female rats","authors":"Jose Nayana, Byrathnahalli S. Shankaranarayana Rao, Bettadapura N. Srikumar","doi":"10.1002/jnr.25306","DOIUrl":"10.1002/jnr.25306","url":null,"abstract":"Finasteride is used in female-pattern hair loss, hirsutism, and polycystic ovarian syndrome. It inhibits 5α-reductase, which is an important enzyme in the biosynthesis of neurosteroids. The effects of finasteride treatment on mental health in female patients as well as the effects of repeated/chronic finasteride administration in female rodents are still unknown. Accordingly, in our study, we administered finasteride (10, 30, or 100 mg/Kg, s.c.) for 6 days in female rats and evaluated behavior, plasma steroid levels, and synaptic plasticity. Depression-like behavior was evaluated using forced swim test (FST) and splash test. Anxiety-like behavior was evaluated using novelty-suppressed feeding task (NSFT), elevated plus maze (EPM), open field test (OFT), and light–dark test (LDT). Plasma steroid levels were assessed using ELISA and synaptic plasticity by field potential recordings. We observed that finasteride decreased total immobility duration in FST, indicating antidepressant-like effect and decreased the latency to first bite in NSFT, showing anxiolytic-like effect. We also found a significant increase in plasma estradiol and a significant decrease in plasma corticosterone level. Furthermore, field potential recordings showed that finasteride increased hippocampal long-term potentiation. These results indicate that repeated finasteride administration in female rats may have antidepressant- and anxiolytic-like effect, which might be mediated by enhanced estradiol levels or decreased corticosterone levels. Further studies are required to validate the molecular mechanisms underlying the effects of finasteride in female rats. Understanding the mechanisms will help us in developing novel neurosteroid-based therapeutics in the treatment of neuropsychiatric disorders in women.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation in obsessive–compulsive disorder: A literature review and hypothesis-based potential of transcranial photobiomodulation 强迫症中的炎症：文献综述和基于假设的经颅光生物调制潜力。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-08 DOI: 10.1002/jnr.25317

David Richer Araujo Coelho, Joshua D. Salvi, Willians Fernando Vieira, Paolo Cassano

{"title":"Inflammation in obsessive–compulsive disorder: A literature review and hypothesis-based potential of transcranial photobiomodulation","authors":"David Richer Araujo Coelho, Joshua D. Salvi, Willians Fernando Vieira, Paolo Cassano","doi":"10.1002/jnr.25317","DOIUrl":"10.1002/jnr.25317","url":null,"abstract":"Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects about 2%–3% of the global population. Despite the availability of several treatments, many patients with OCD do not respond adequately, highlighting the need for new therapeutic approaches. Recent studies have associated various inflammatory processes with the pathogenesis of OCD, including alterations in peripheral immune cells, alterations in cytokine levels, and neuroinflammation. These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t-PBM) with near-infrared light is a noninvasive neuromodulation technique that has shown potential for several neuropsychiatric disorders. However, its efficacy in OCD remains to be fully explored. This study aimed to review the literature on inflammation in OCD, detailing associations with T-cell populations, monocytes, NLRP3 inflammasome components, microglial activation, and elevated proinflammatory cytokines such as TNF-α, CRP, IL-1β, and IL-6. We also examined the hypothesis-based potential of t-PBM in targeting these inflammatory pathways of OCD, focusing on mechanisms such as modulation of oxidative stress, regulation of immune cell function, reduction of proinflammatory cytokine levels, deactivation of neurotoxic microglia, and upregulation of BDNF gene expression. Our review suggests that t-PBM could be a promising, noninvasive intervention for OCD, with the potential to modulate underlying inflammatory processes. Future research should focus on randomized clinical trials to assess t-PBM's efficacy and optimal treatment parameters in OCD. Biomarker analyses and neuroimaging studies will be important in understanding the relationship between inflammatory modulation and OCD symptom improvement following t-PBM sessions.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in functional connectivity and the predictive role of the connectome-based predictive model in Alzheimer's disease 功能连接的性别差异和基于连接体的阿尔茨海默病预测模型的预测作用。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-05 DOI: 10.1002/jnr.25307

Yuqing Li, Wanqiu Zhu, Shanshan Zhou, Hui Li, Ziwen Gao, Ziang Huang, Xiaohu Li, Yongqiang Yu, Xiaoshu Li

{"title":"Sex differences in functional connectivity and the predictive role of the connectome-based predictive model in Alzheimer's disease","authors":"Yuqing Li, Wanqiu Zhu, Shanshan Zhou, Hui Li, Ziwen Gao, Ziang Huang, Xiaohu Li, Yongqiang Yu, Xiaoshu Li","doi":"10.1002/jnr.25307","DOIUrl":"10.1002/jnr.25307","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline. Sex differences in the progression of AD exist, but the neural mechanisms are not well understood. The purpose of the current study was to explore sex differences in brain functional connectivity (FC) at different stages of AD and their predictive ability on Montreal Cognitive Assessment (MoCA) scores using connectome-based predictive modeling (CPM). Resting-state functional magnetic resonance imaging was collected from 81 AD patients (44 females), 78 amnestic mild cognitive impairment patients (44 females), and 92 healthy controls (50 females). The FC analysis was conducted and the interaction effect between sex and group was investigated using two-factor variance analysis. The CPM was used to predict MoCA scores. There were sex-by-group interaction effects on FC between the left dorsolateral superior frontal gyrus and left middle temporal gyrus, left precuneus and right calcarine fissure surrounding cortex, left precuneus and left middle occipital gyrus, left middle temporal gyrus and left precentral gyrus, and between the left middle temporal gyrus and right cuneus. In the CPM, the positive network predictive model significantly predicted MoCA scores in both males and females. There were significant sex-by-group interaction effects on FC between the left precuneus and left middle occipital gyrus, and between the left middle temporal gyrus and right cuneus could predict MoCA scores in female patients. Our results suggest that there are sex differences in FC at different stages of AD. The sex-specific FC can further predict MoCA scores at individual level.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0