Journal of Neuroscience Research最新文献

筛选
英文 中文
A Novel Mutation in CNTNAP1 Gene Causes Disorganization of Axonal Domains, Hypomyelination and Severe Neurological Deficits CNTNAP1基因的新突变导致轴突结构域的紊乱、髓鞘化降低和严重的神经功能障碍
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-23 DOI: 10.1002/jnr.70040
Lacey B. Sell, Carson Zabel, Sabine Weller Grønborg, Qian Shi, Manzoor A. Bhat
{"title":"A Novel Mutation in CNTNAP1 Gene Causes Disorganization of Axonal Domains, Hypomyelination and Severe Neurological Deficits","authors":"Lacey B. Sell,&nbsp;Carson Zabel,&nbsp;Sabine Weller Grønborg,&nbsp;Qian Shi,&nbsp;Manzoor A. Bhat","doi":"10.1002/jnr.70040","DOIUrl":"https://doi.org/10.1002/jnr.70040","url":null,"abstract":"<div>\u0000 \u0000 <p><i>CNTNAP1</i> encodes the contactin-associated protein 1 (Cntnap1) which localizes to the paranodal region in all myelinated axons and is essential for axonal domain organization and the propagation of action potentials. To date, close to 45 reported human <i>CNTNAP1</i> variants have been identified that are associated with dysregulation and disorganization of the axonal domains, resulting in various forms of congenital hypomyelinating neuropathies in children. Currently, no treatments are available for neuropathies caused by <i>CNTNAP1</i> variants, highlighting the importance of fully characterizing these mutations and their impact on Cntnap1 functions. To understand the importance of a novel human <i>CNTNAP1</i> likely pathogenic variant that changes glycine at position 349 to valine in a child who also carries a <i>CNTNAP1</i> truncation and displayed severe neurological deficits, we used <i>CRISPR/Cas9</i> methodology and introduced a single nucleotide substitution in the mouse <i>Cntnap1</i> gene, resulting in glycine at 350 to valine (<i>Cntnap1</i><sup><i>G350V</i></sup>). Trans-allelic combination of <i>Cntnap1</i><sup><i>G350V</i></sup> with a <i>Cntnap1</i> null allele (<i>Cntnap1</i><sup><i>G350V/−</i></sup>) mimics human pathologies, recapitulating hypomyelination neuropathies <i>associated with CNTNAP1</i> mutations as well as loss of paranodal junctions and disorganization of axonal domains in myelinated axons. Expression of the wild type <i>Cntnap1</i> transgene in <i>Cntnap1</i><sup><i>G350V/−</i></sup> mice rescued the mutant phenotypes and restored all neurological deficits. Our studies demonstrate that GGT (glycine) to GTT (valine) change in human <i>CNTNAP1</i> creates a recessive loss of function allele and lays the foundation for potential gene therapy studies aimed at treating <i>CNTNAP1</i>-associated hypomyelinating neuropathies in children.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: Lithium Inhibits Aβ-Induced Stress in Endoplasmic Reticulum of Rabbit Hippocampus but Does Not Prevent Oxidative Damage and Tau Phosphorylation 关注表达:锂抑制a β诱导的兔海马内质网应激,但不能防止氧化损伤和Tau磷酸化
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-22 DOI: 10.1002/jnr.70031
{"title":"EXPRESSION OF CONCERN: Lithium Inhibits Aβ-Induced Stress in Endoplasmic Reticulum of Rabbit Hippocampus but Does Not Prevent Oxidative Damage and Tau Phosphorylation","authors":"","doi":"10.1002/jnr.70031","DOIUrl":"https://doi.org/10.1002/jnr.70031","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: O. Ghribi, M. M. Herman and J. Savory, “Lithium Inhibits Aβ-Induced Stress in Endoplasmic Reticulum of Rabbit Hippocampus but Does Not Prevent Oxidative Damage and Tau Phosphorylation,” <i>Journal of Neuroscience Research</i> 71, no. 6 (2003): 853–862, https://doi.org/10.1002/jnr.10511.</p><p>This Expression of Concern is for the above article, published online on 04 February 2003 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Lawrence S. Sherman; and Wiley Periodicals LLC. The Expression of Concern has been agreed due to overlap between images presented in Figures 5H and 5I. Due to the time that has elapsed, the original raw data of this manuscript is no longer available. Although the conclusions are not believed to be affected, the journal is issuing this expression of concern to alert readers.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Effect of growth factors and steroids on transglutaminase activity and expression in primary astroglial cell cultures 回归:生长因子和类固醇对原代星形胶质细胞培养物中转谷氨酰胺酶活性和表达的影响
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-22 DOI: 10.1002/jnr.70037
{"title":"RETRACTION: Effect of growth factors and steroids on transglutaminase activity and expression in primary astroglial cell cultures","authors":"","doi":"10.1002/jnr.70037","DOIUrl":"https://doi.org/10.1002/jnr.70037","url":null,"abstract":"<p><b>RETRACTION:</b> A. Campisi, V. Bramanti, D. Caccamo, G. Li Volti, G. Cannavò, M. Currò, G. Raciti, F. Galvano, F. Amenta, A. Vanella, R. Ientile, R. Avola, “Effect of growth factors and steroids on transglutaminase activity and expression in primary astroglial cell cultures,” <i>Journal of Neuroscience Research</i> 86, no. 6 (2008): 1297–1305, https://doi.org/10.1002/jnr.21579.</p><p>The above article, published online on 26 November 2007 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lawrence S. Sherman; and John Wiley &amp; Sons, Inc. Following publication, concerns were raised by a third party that portions of Figures 1 and 8 were duplicated and manipulated, and that portions of Figure 8 were duplicated from an earlier publication by this research group. Internal investigation confirmed these claims. The publisher attempted to contact the authors and request original data, but the authors did not respond. The retraction has been agreed because of concerns that the images were manipulated, affecting the interpretation of the data and results presented. The authors have been notified of the retraction.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Neuroactive Molecules and Growth Factors Modulate Cytoskeletal Protein Expression During Astroglial Cell Proliferation and Differentiation in Culture 摘编:神经活性分子和生长因子在星形胶质细胞增殖和分化过程中调节细胞骨架蛋白的表达
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-22 DOI: 10.1002/jnr.70036
{"title":"RETRACTION: Neuroactive Molecules and Growth Factors Modulate Cytoskeletal Protein Expression During Astroglial Cell Proliferation and Differentiation in Culture","authors":"","doi":"10.1002/jnr.70036","DOIUrl":"https://doi.org/10.1002/jnr.70036","url":null,"abstract":"<p><b>RETRACTION:</b> V. Bramanti, S. Grasso, D. Tibullo, C. Giallongo, R. Pappa, MV Brundo, D. Tomassoni, M. Viola, F. Amenta, and R. Avola, “Neuroactive Molecules and Growth Factors Modulate Cytoskeletal Protein Expression During Astroglial Cell Proliferation and Differentiation in Culture,” <i>Journal of Neuroscience Research</i> 94, no. 1 (2016): 90-98, https://doi.org/10.1002/jnr.23678.</p><p>The above article, published online on 15 October 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lawrence S. Sherman; and John Wiley &amp; Sons, Inc. Following publication, concerns were raised by a third party that portions of Figures 2B and 3 were duplicated and manipulated, and that most of the images from Figure 2A were duplicated and manipulated from an earlier publication by this research group. Internal investigation confirmed these claims. The publisher attempted to contact the authors and request original data, but the authors did not respond. The retraction has been agreed because of concerns that the images were manipulated, affecting the interpretation of the data and results presented. The authors have been notified of the retraction.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: Gene Expression Profile Activated by the Chemokine CCL5/RANTES in Human Neuronal Cells 关注表达:趋化因子CCL5/RANTES在人类神经元细胞中激活的基因表达谱
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-22 DOI: 10.1002/jnr.70038
{"title":"EXPRESSION OF CONCERN: Gene Expression Profile Activated by the Chemokine CCL5/RANTES in Human Neuronal Cells","authors":"","doi":"10.1002/jnr.70038","DOIUrl":"https://doi.org/10.1002/jnr.70038","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN:</b> A. Valerio, M. Ferrario, F.O. Martinez, M. Locati, V. Ghisi, L. Grazia Bresciani, A. Mantovani, P. Spano, “Gene Expression Profile Activated by the Chemokine CCL5/RANTES in Human Neuronal Cells,” <i>Journal of Neuroscience Research</i> 78, no. 3 (2004): 371-382, https://doi.org/10.1002/jnr.20250.</p><p>This Expression of Concern is for the above article, published online on 23 August 2004 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Lawrence S. Sherman; and John Wiley &amp; Sons, Inc. Following publication, concerns were raised by a third party that the control actin bands had been duplicated within Figure 2. While the image manipulation does not seem to affect the conclusions of the paper, the journal has decided to issue an Expression of Concern to inform and alert readers. The authors have been notified of the Expression of Concern.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and Strain Differences in Analgesic and Hyperlocomotor Effects of Morphine and μ-Opioid Receptor Expression in Mice 吗啡和μ-阿片受体表达在小鼠镇痛和高运动作用中的性别和应变差异
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-18 DOI: 10.1002/jnr.70039
Damien C. Boorman, Simran K. Rehal, Maryam Fazili, Loren J. Martin
{"title":"Sex and Strain Differences in Analgesic and Hyperlocomotor Effects of Morphine and μ-Opioid Receptor Expression in Mice","authors":"Damien C. Boorman,&nbsp;Simran K. Rehal,&nbsp;Maryam Fazili,&nbsp;Loren J. Martin","doi":"10.1002/jnr.70039","DOIUrl":"https://doi.org/10.1002/jnr.70039","url":null,"abstract":"<p>Sex and gender differences in the analgesic efficacy and side effects of opioids have been widely reported, but their underlying neurobiological mechanisms remain poorly understood. Preclinical animal models are essential tools for investigating these differences and providing insights into the neurobiology of opioid effects. Although studies in rats have revealed sex-specific effects of opioids, the sex-dependent behavioral profiles of opioids in mice, particularly across strains, remain largely unexplored. In this study, we characterized sex and strain differences in the antinociceptive and hyperlocomotor effects of morphine in the two most widely used mouse strains—CD1 and C57BL/6—and quantified regional expression of the μ-opioid receptor (MOR) in key brain and spinal cord regions. Both strains exhibited clear, dose-dependent antinociceptive and hyperlocomotor responses to morphine. While no significant sex or strain differences were observed in antinociceptive effects, C57BL/6 mice displayed significantly greater hyperlocomotor activity than CD1 mice. Western blot analyses revealed strain-specific MOR expression, with CD1 mice showing higher spinal cord and periaqueductal gray MOR levels, particularly in females, while C57BL/6 mice exhibited elevated MOR expression in the caudoputamen. Morphine treatment increased spinal MOR expression in CD1 mice but not C57BL/6, suggesting strain-dependent regulation of MOR. These findings highlight strain-specific behavioral and molecular responses to morphine, emphasizing the importance of strain and sex considerations in preclinical opioid research.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative MRI of the Spinal Cord and Brain in Chronic Traumatic Spinal Cord Injury: In Vivo Assessment of Structural Changes 慢性外伤性脊髓损伤脊髓和脑的定量MRI:体内结构变化的评估
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-11 DOI: 10.1002/jnr.70030
Jing Li, Xiaojing Zhao, Yi Shan, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
{"title":"Quantitative MRI of the Spinal Cord and Brain in Chronic Traumatic Spinal Cord Injury: In Vivo Assessment of Structural Changes","authors":"Jing Li,&nbsp;Xiaojing Zhao,&nbsp;Yi Shan,&nbsp;Guixiang Shan,&nbsp;Peng-Hu Wei,&nbsp;Lin Liu,&nbsp;Changming Wang,&nbsp;Hang Wu,&nbsp;Weiqun Song,&nbsp;Yi Tang,&nbsp;Guo-Guang Zhao,&nbsp;Jie Lu","doi":"10.1002/jnr.70030","DOIUrl":"https://doi.org/10.1002/jnr.70030","url":null,"abstract":"<div>\u0000 \u0000 <p>The prolonged survival of traumatic spinal cord injury (TSCI) patients underscores the need to customize rehabilitative treatment plans according to patients' characteristics, aiming to restore motor function. We conducted a cross-sectional study of two groups with chronic TSCI (short-term group: 11 patients with an injury time of 1–2 years; long-term group: 10 patients with an injury time &gt; 2 years) and 16 controls. Quantitative MRI was used to evaluate structural changes in the upper spinal cord and brain. Compared to controls, both groups exhibited decreased fractional anisotropy (close relationship of the decreased) in the spinal cord, and the long-term group showed reduced spinal cord cross-sectional areas. The short-term group presented increased gray matter volumes (GMVs) in the paracentral lobule, postcentral gyrus, and supplementary motor area, indicating compensatory neural changes, whereas the long-term group exhibited decreased GMV in cerebellar lobule VI, suggesting weakening of the signal received by the cerebellum. Track-based spatial statistics revealed the close relationship of the decreased FA was with the increased radial diffusivity in the long-term group, indicating that demyelination mainly altered the white matter. Correlation analysis revealed that the increased GMV was negatively correlated with the sensorimotor score (<i>r</i> = −0.725, <i>p</i> = 0.018). Additionally, the GMV of cerebellar lobule VI was positively correlated with the sensorimotor score (<i>r</i> = 0.671, <i>p</i> = 0.024). In summary, quantitative MRI identifies structural changes in the brain and spinal cord of patients with chronic TSCI that vary with the time since injury and provide imaging evidence for the development of precise targeted therapies.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabidiol-Rich Cannabis sativa L. Extract Alleviates LPS-Induced Neuroinflammation Behavioral Alterations, and Astrocytic Bioenergetic Impairment in Male Mice 富含大麻二酚的大麻提取物减轻lps诱导的雄性小鼠神经炎症、行为改变和星形细胞生物能量损伤
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-08 DOI: 10.1002/jnr.70035
Hind Ibork, Zakaria Ait Lhaj, Khadija Boualam, Sara El Idrissi, Ahmet B. Ortaakarsu, Lhoussain Hajji, Annabelle Manalo Morgan, Farid Khallouki, Khalid Taghzouti, Oualid Abboussi
{"title":"Cannabidiol-Rich Cannabis sativa L. Extract Alleviates LPS-Induced Neuroinflammation Behavioral Alterations, and Astrocytic Bioenergetic Impairment in Male Mice","authors":"Hind Ibork,&nbsp;Zakaria Ait Lhaj,&nbsp;Khadija Boualam,&nbsp;Sara El Idrissi,&nbsp;Ahmet B. Ortaakarsu,&nbsp;Lhoussain Hajji,&nbsp;Annabelle Manalo Morgan,&nbsp;Farid Khallouki,&nbsp;Khalid Taghzouti,&nbsp;Oualid Abboussi","doi":"10.1002/jnr.70035","DOIUrl":"https://doi.org/10.1002/jnr.70035","url":null,"abstract":"<div>\u0000 \u0000 <p>Neuroinflammation is a hallmark of various neurodegenerative disorders, yet effective treatments remain limited. This study investigates the neuroprotective potential of a cannabidiol (CBD)-Rich <i>Cannabis sativa</i> L. (CS) extract in a lipopolysaccharide (LPS)-induced neuroinflammation mouse model. The effects on anxiety-like behavior, cognitive function, and locomotor activity were assessed using behavioral tests (open field, elevated plus maze, novel object recognition, and Morris water maze). Antioxidant activity was measured by assaying glutathione (GSH) levels and lipid peroxidation by-products (TBARs). Anti-inflammatory properties were evaluated using quantitative reverse transcription polymerase chain reaction (QRt-PCR) for proinflammatory cytokines (IL-6 and TNF-α), glial fibrillary acidic protein (GFAP), and cannabinoid receptor 1 (CB1) mRNAs in the prefrontal cortex (PFC). Astrocytic bioenergetics were analyzed using extracellular flux assays. Additionally, computational inference with a deep learning approach was conducted to evaluate the synergistic interactions among CS phytocompounds on the CB1 receptors. Compared with synthetic CBD, the CS extract (20.0 mg/kg) demonstrated superior efficacy in mitigating LPS-induced anxiety-like behavior, cognitive deficits, and locomotor impairments. It also significantly mitigated oxidative stress (increased GSH, reduced TBARs) and suppressed proinflammatory cytokines and GFAP mRNAs, indicating potent anti-inflammatory properties. The extract modulated CB1 receptor expression and preserved metabolic homeostasis in cortical astrocytes, preventing their shift from glycolysis to oxidative phosphorylation under neuroinflammatory conditions. Computational modeling highlighted conformational changes in CB1 receptor residues induced by Delta-9-THC that enhanced CBD binding. These findings underscore the potential of CS extract as a therapeutic candidate for managing neuroinflammation and its associated neurodegenerative consequences, warranting further clinical exploration.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Life Stress Induces Brain Mitochondrial Dynamics Changes and Sex-Specific Adverse Effects in Adulthood 早期生活压力诱导成年期脑线粒体动力学变化和性别特异性不良反应
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-08 DOI: 10.1002/jnr.70023
Angeliki-Maria Vlaikou, Markus Nussbaumer, Aikaterini Iliou, Maria P. Papageorgiou, Chrysoula Komini, Daniela Theodoridou, Dimitra Benaki, Emmanuel Mikros, Evangelos Gikas, Maria Syrrou, Michaela D. Filiou
{"title":"Early Life Stress Induces Brain Mitochondrial Dynamics Changes and Sex-Specific Adverse Effects in Adulthood","authors":"Angeliki-Maria Vlaikou,&nbsp;Markus Nussbaumer,&nbsp;Aikaterini Iliou,&nbsp;Maria P. Papageorgiou,&nbsp;Chrysoula Komini,&nbsp;Daniela Theodoridou,&nbsp;Dimitra Benaki,&nbsp;Emmanuel Mikros,&nbsp;Evangelos Gikas,&nbsp;Maria Syrrou,&nbsp;Michaela D. Filiou","doi":"10.1002/jnr.70023","DOIUrl":"https://doi.org/10.1002/jnr.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>Early life stress exposure exerts detrimental effects in adulthood and is a risk factor for psychiatric disorders. Studies addressing the molecular mechanisms of early life stress have primarily focused on hormones and stress circuits. However, little is known on how mitochondria and mitochondrial dynamics (i.e., the orchestration of mitochondrial fission, fusion, mitophagy, and biogenesis) modulate early life stress responses. Here, we used a maternal separation with early weaning (MSEW) paradigm to investigate the behavioral and molecular early life stress-elicited effects in male and female C57BL/6 mice in adulthood. We first applied a behavioral test battery to assess MSEW-driven, anxiety-related and stress-coping alterations. We then looked for MSEW-induced, mitochondria-centered changes in cingulate cortex, hippocampus and cerebellum, as well as in plasma by combining protein, mRNA, mitochondrial DNA copy number (mtDNAcn) and metabolomics analyses. We found that MSEW mice are more anxious, show decreased antioxidant capacity in the cingulate cortex and have higher mRNA levels of the fission regulator <i>Fis1</i> and the mitophagy activator <i>Pink1</i> in the hippocampus, indicating a shift towards mitochondrial degradation. Hippocampal mRNA level alterations of apoptotic markers further suggest an MSEW-driven activation of apoptosis accompanied by a dysregulation of purine catabolism in the cerebellum in MSEW mice. Sex-specific analysis revealed distinct MSEW-induced changes in male and female mice at the molecular level. Our work reveals a previously unexplored role of mitochondrial dynamics in regulating early life stress effects and highlights a mitochondria-centered dysregulation as a persistent outcome of early life stress in adulthood.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities After Injury MRI-T2弛豫测量在轻度创伤性脑损伤中增加:损伤后急性脑异常的指征
IF 2.9 3区 医学
Journal of Neuroscience Research Pub Date : 2025-04-03 DOI: 10.1002/jnr.70034
Mayan J. Bedggood, Christi A. Essex, Alice Theadom, Helen Murray, Patria Hume, Samantha J. Holdsworth, Richard L. M. Faull, Mangor Pedersen
{"title":"MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities After Injury","authors":"Mayan J. Bedggood,&nbsp;Christi A. Essex,&nbsp;Alice Theadom,&nbsp;Helen Murray,&nbsp;Patria Hume,&nbsp;Samantha J. Holdsworth,&nbsp;Richard L. M. Faull,&nbsp;Mangor Pedersen","doi":"10.1002/jnr.70034","DOIUrl":"https://doi.org/10.1002/jnr.70034","url":null,"abstract":"<p>Mild traumatic brain injury (mTBI) is a common condition, particularly pervasive in contact sports environments. A range of symptoms can accompany this type of injury and negatively impact people's lives. As mTBI diagnosis and recovery largely rely on subjective reports, more objective injury markers are needed. The current study compared structural brain MRI-T2 relaxometry between a group of 40 male athletes with mTBI within 14 days of injury and 40 age-matched male controls. Voxel-averaged T2 relaxometry within the gray matter was increased for the mTBI group compared to controls (<i>p</i> &lt; 0.001), with statistically significant increased T2 relaxometry particularly in superior cortical regions. Our findings indicate subtle brain abnormalities can be identified in acute mTBI using MRI-T2 relaxometry. These brain abnormalities may reflect inflammation present in the brain and could constitute an objective injury marker to supplement current subjective methods that dominate clinical decisions regarding diagnosis and prognosis. Future research should validate this potential marker with other data types, such as blood biomarkers or histological samples.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信