Journal of Neuroscience Research最新文献

Piano Training Induces Dynamic Neuroplasticity of Bimanual Coordination but Not Auditory Processing in Young Adults 钢琴训练诱导青少年双手协调的动态神经可塑性，但对听觉加工无影响

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-12 DOI: 10.1002/jnr.70067

Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Katarzyna Jednoróg, Artur Marchewka, Aleksandra M. Herman

{"title":"Piano Training Induces Dynamic Neuroplasticity of Bimanual Coordination but Not Auditory Processing in Young Adults","authors":"Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Katarzyna Jednoróg, Artur Marchewka, Aleksandra M. Herman","doi":"10.1002/jnr.70067","DOIUrl":"https://doi.org/10.1002/jnr.70067","url":null,"abstract":"<div>\u0000 \u0000 <p>Piano training enables the study of the interplay between the auditory and motor domains in the acquisition of complex skill. Here, we uniquely combine longitudinal and cross-sectional designs to show how the motor and auditory brain systems respond in novice pianists over a 6-month training period. In the auditory domain, we found no differences in brain activation between novice pianists and a passive control group. In a specially designed piano task on an MRI-compatible keyboard, we demonstrate that the time course of neuroplastic reorganization in the cortical and subcortical regions reflects the shift from spatial attention to automated movements, but depends on task demands related to bimanual coordination. Importantly, no single model of brain plasticity can fully explain the observed dynamic time courses of functional changes. Finally, we demonstrate that the increased activation in the dorsal premotor and parietal cortices in novice pianists compared to skilled musicians while performing the motor task vanishes within the first 6 months of training. These results present converging evidence that the dynamic musical-training-related plasticity is highly contextual, and underscore the importance of ecological designs in research on skill acquisition.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Nerve Repair: Historical Perspectives, Current Advances, and Future Directions in Natural and Synthetic Neural Conduits 周围神经修复：自然和合成神经导管的历史观点、当前进展和未来方向

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-08 DOI: 10.1002/jnr.70060

Tayebeh Sadat Tabatabai, Morteza Alizadeh, Mohammad Kamalabadi Farahani, Arian Ehterami, Shahin Gharedaghi Kloucheh, Majid Salehi

{"title":"Peripheral Nerve Repair: Historical Perspectives, Current Advances, and Future Directions in Natural and Synthetic Neural Conduits","authors":"Tayebeh Sadat Tabatabai, Morteza Alizadeh, Mohammad Kamalabadi Farahani, Arian Ehterami, Shahin Gharedaghi Kloucheh, Majid Salehi","doi":"10.1002/jnr.70060","DOIUrl":"https://doi.org/10.1002/jnr.70060","url":null,"abstract":"<div>\u0000 \u0000 <p>Regenerative medicine aims to restore damaged tissues or organs using stem cells, biomaterials, and decellularized grafts. Peripheral nerve injuries (PNI), affecting 2.8% of patients, lead to severe functional impairments with global socioeconomic costs exceeding $7 billion annually. Despite advancements in surgical techniques, full functional recovery remains elusive, particularly in critical gap injuries (> 3 cm). Autografts remain the gold standard but are hindered by donor tissue scarcity and complications like neuroma formation. Allografts face challenges due to the lack of Schwann cells and neurotrophic support. Emerging approaches in tissue engineering leverage synthetic materials, such as polycaprolactone (PCL) and polylactic acid (PLA), and biological scaffolds like decellularized nerve grafts. These innovations provide structural support, promote axonal regeneration, and retain extracellular matrix components, enabling cell adhesion and migration while minimizing antigenicity. However, barriers such as mechanical instability, scar tissue formation, and inadequate cellularization persist. This review explores the anatomy and clinical significance of the sciatic nerve, historical perspectives on peripheral nerve repair, and current treatment strategies. It evaluates biological and synthetic nerve conduits, highlighting FDA-approved products and their advantages in promoting nerve regeneration. Additionally, the paper discusses challenges in the field, including limited functional recovery and the need for more effective clinical solutions. By combining natural and synthetic materials with growth factor delivery and vascularization strategies, engineered scaffolds hold promise for improving outcomes in PNI repair. Further research is essential to optimize these technologies and bridge existing gaps in clinical practice.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Prevents Neuronal Loss and Inhibits Development of Spontaneous Recurrent Seizures via the PPARγ/PTEN/Akt Pathway in Chronic Epilepsy 姜黄素通过PPARγ/PTEN/Akt通路预防慢性癫痫的神经元丢失和抑制自发性复发性癫痫发作

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-04 DOI: 10.1002/jnr.70064

Sun Hong, Liu GuoYan, Wu JiaWen, Yu Xin, Zhan ShuQin, Reng HongWei, Chen MengYing, Cheng YuXuan

{"title":"Curcumin Prevents Neuronal Loss and Inhibits Development of Spontaneous Recurrent Seizures via the PPARγ/PTEN/Akt Pathway in Chronic Epilepsy","authors":"Sun Hong, Liu GuoYan, Wu JiaWen, Yu Xin, Zhan ShuQin, Reng HongWei, Chen MengYing, Cheng YuXuan","doi":"10.1002/jnr.70064","DOIUrl":"https://doi.org/10.1002/jnr.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic epilepsy is mainly characterized by spontaneous recurrent seizures (SRS). The peroxisome proliferator activated receptor gamma/phosphatase and tensin homolog/protein kinase B (PPARγ/PTEN/Akt) pathway is involved in the pathogenesis of SRS and neuronal loss. Curcumin is a natural compound, and previous studies have shown it provides neuroprotection via anti-inflammation and anti-oxidant effects in many central nervous system (CNS) diseases. In the present study, we show that curcumin regulates the abnormal expression of PTEN and Akt in the SRS phase, improves the neuronal loss in the hippocampus, and suppresses SRS development and seizure spike activity in epileptic rats. More importantly, these effects are reversed by the PPARγ antagonist, T0070907, suggesting that curcumin exerts neuroprotective and anti-epileptic effects through the PPARγ/PTEN/Akt signaling pathway. Other studies have shown that curcumin can cross the BBB and has a safety profiles and pleiotropic pharmacological effects. Thus, our data support the proposition that curcumin might be a potential neuroprotective and anti-epileptic agent for chronic epilepsy.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P2X7R: A Critical Regulator and Potential Therapeutic Target for Glioma P2X7R：神经胶质瘤的关键调控因子和潜在治疗靶点

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-03 DOI: 10.1002/jnr.70065

Meng Yan, Ronglan Zhao, Yanwen Xue, Yahui Cao, Yanan Du, Xiaoxiang Peng

{"title":"P2X7R: A Critical Regulator and Potential Therapeutic Target for Glioma","authors":"Meng Yan, Ronglan Zhao, Yanwen Xue, Yahui Cao, Yanan Du, Xiaoxiang Peng","doi":"10.1002/jnr.70065","DOIUrl":"https://doi.org/10.1002/jnr.70065","url":null,"abstract":"<div>\u0000 \u0000 <p>Glioma is the most common primary brain tumor, characterized by high invasiveness and poor prognosis. The purinergic ligand-gated ion channel 7 receptor (P2X7R), an ion channel-type purinergic receptor with adenosine triphosphate (ATP) as its ligand, is widely expressed in various tumor cells, including glioma. Moreover, it plays crucial biological functions in the progression of glioma. P2X7R promotes the proliferation, invasion, and metastasis of glioma by activating multiple signaling pathways, facilitating epithelial–mesenchymal transition (EMT), promoting the release of extracellular vesicles (EVs) and regulating the tumor microenvironment (TME) of glioma. However, the activation of P2X7R by high concentrations of ATP can induce cell necrosis or pyroptosis, exerting an anti-glioma effect. The bidirectional nature of its functions may be related to differences in the subtypes of P2X7R, cell types, as well as the TME. P2X7R antagonists can inhibit its effect in glioma, while the expression of P2X7R can enhance the efficacy of radiotherapy and chemotherapy. In this review, the structure and function of P2X7R, its role in tumor, especially its mechanism of action in glioma, and its latent capacity value as a target for therapeutic of glioma were reviewed in detail.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Neural Pathways of Empathic Pain: Implications for Modulation Strategies and Beyond 揭示共情疼痛的神经通路：对调节策略的启示及其他

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-01 DOI: 10.1002/jnr.70063

Yingying Zhang, Kun Zhang, Hengxin Gong, Minggao Zhao, Lanxin Luo

{"title":"Unveiling the Neural Pathways of Empathic Pain: Implications for Modulation Strategies and Beyond","authors":"Yingying Zhang, Kun Zhang, Hengxin Gong, Minggao Zhao, Lanxin Luo","doi":"10.1002/jnr.70063","DOIUrl":"https://doi.org/10.1002/jnr.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>Empathic pain, a core manifestation of empathy, encompasses an individual's perceptual sensitivity, evaluative judgment, and emotional responsiveness to the suffering of others. This capacity is vital for healthy social interaction, as it fosters prosocial behavior, inhibits aggression, and upholds moral norms critical to social development. This article provides a comprehensive review of current research on empathic pain, examining its conceptual foundations and the underlying neural mechanisms. In particular, it explores the activation of key brain regions, including the anterior cingulate cortex, insula, amygdala, and cerebellum, as well as the neural circuits linking these areas. Additionally, the paper summarizes various influencing factors and modulatory strategies related to empathic pain. These insights enhance our understanding of emotional resonance and establish a solid basis for developing clinical modulation models. Future research should adopt a multidisciplinary approach, incorporating advanced neuroimaging techniques, behavioral experiments, and broader clinical trials to further elucidate empathic pain and inform the development of more effective treatment strategies.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development 单神经元放电与癫痫发生和癫痫发展中的高频振荡动力学相关

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-30 DOI: 10.1002/jnr.70062

Xiaonan Li, Shipei He, Jiaoyang Wang, Guoyun Feng, Donghong Li, Yue Xing, Yu Yang, Wentao Dai, Jiaqing Yan, Xiaofeng Yang, Liemin Zhou

{"title":"Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development","authors":"Xiaonan Li, Shipei He, Jiaoyang Wang, Guoyun Feng, Donghong Li, Yue Xing, Yu Yang, Wentao Dai, Jiaqing Yan, Xiaofeng Yang, Liemin Zhou","doi":"10.1002/jnr.70062","DOIUrl":"https://doi.org/10.1002/jnr.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>The mechanism of epilepsy is still unclear. We aim to explore the relationship between high-frequency oscillations (HFOs) dynamics and epilepsy, with a focus on deciphering underlying mechanisms at the single-neuron level. Using a rat model of chronic focal cortical epilepsy induced by cobalt-wire implantation, we monitored the seizures and HFO dynamics, as well as the cross-frequency coupling trends between HFOs and theta activities. Additionally, excitatory and inhibitory neurons' discharges were recorded by 16-channel tetrode electrode, with comparisons made between the discharge rates and changes from baselines during different bands of HFOs (ripple:80-200 Hz; fast ripple, FRs:200-500 Hz). All rats (8/8) with cobalt-wire implantation developed spontaneous seizures within 4 to 8 days post-surgery, in contrast to the control group (3/3) with steel-wire insertion remaining seizure-free. HFOs exhibited a progressive increase over time post-surgery in the epilepsy model, while minimal HFOs was observed in the control group. HFOs recorded during the peak-seizure periods showed a propensity to synchronize with the trough of theta activity, coinciding with heightened seizure frequency. A substantial augmentation showed in the discharge rates of both putative excitatory and inhibitory neurons during HFO occurrences. The change ratios between putative excitatory and inhibitory neurons during ripples were smaller than those during FRs. In conclusion, we found that HFO dynamics reflect epileptogenic network formation, with implications for early seizure prediction and therapeutic interventions. Our data provide novel insights at cellular and cross-frequency level into the mechanistic underpinnings of HFO emergence and network reorganization offering potential strategies for targeting pathological network activity in epilepsy.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells 硫代氨基酸氯胺酮乙酯诱导小鼠少突胶质细胞祖细胞增殖成熟并调节钙通量

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-27 DOI: 10.1002/jnr.70061

Veronica T. Cheli, Swathi G. Tumuluri, Zachary McDonald, Travis T. Denton, Jeffrey L. Dupree, Pablo M. Paez, Douglas L. Feinstein

{"title":"Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells","authors":"Veronica T. Cheli, Swathi G. Tumuluri, Zachary McDonald, Travis T. Denton, Jeffrey L. Dupree, Pablo M. Paez, Douglas L. Feinstein","doi":"10.1002/jnr.70061","DOIUrl":"https://doi.org/10.1002/jnr.70061","url":null,"abstract":"<p>Previous studies have shown that lanthionine ketimine ethyl ester (LKE), a semi-synthetic derivative of the endogenous amino acid lanthionine, can induce proliferation and maturation of oligodendrocyte progenitor cells (OPCs) in vivo. In the current study, we examined the effects of LKE on Ca<sup>2+</sup> influx in primary mouse OPCs, as intracellular Ca<sup>2+</sup> can regulate those processes. Treatment with LKE stimulated proliferation of OPCs and increased the number of Olig2+, CC1+, and PLP+ cells. LKE also reduced cell death (caspase-3 expressing cells). Measurements of Ca<sup>2+</sup> flux showed that LKE increased basal Ca<sup>2+</sup> levels, reduced Ca<sup>2+</sup> influx following stimulation with glutamate or ATP, and increased Ca<sup>2+</sup> flux because of depolarization with KCl. Reduced Ca<sup>2+</sup> responses were also observed following treatment with a peptide that disrupts interactions of collapsin response mediated protein 2 (CRMP2), a primary target of LKE. These findings demonstrate regulation of Ca<sup>2+</sup> levels in OPCs by LKE and suggest that these actions may be mediated, in part, by CRMP2. LKE or related analogs could therefore be of benefit for the treatment of multiple sclerosis as well as other demyelinating conditions.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation 运动后脑源性神经营养因子和乳酸的增加并没有显示出直接的相关性

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-24 DOI: 10.1002/jnr.70058

S. K. Ashcroft, K. Basclain, C. Woolnough, M. W. Hoon, S. J. Walsh, L. C. Starc, L. Johnson, S. S. Kuys, A. G. Thompson-Butel

{"title":"Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation","authors":"S. K. Ashcroft, K. Basclain, C. Woolnough, M. W. Hoon, S. J. Walsh, L. C. Starc, L. Johnson, S. S. Kuys, A. G. Thompson-Butel","doi":"10.1002/jnr.70058","DOIUrl":"https://doi.org/10.1002/jnr.70058","url":null,"abstract":"<p>The aim of this study was to determine the relationship between BDNF and lactate concentration, accounting for genotype and sex, before and after a submaximal graded exercise test in 31 adults (37.5 ± 14.0 years, 54.8% female). The presence of the Val66Met polymorphism was identified at baseline, and BDNF and lactate concentrations were measured before and after exercise. Pearson's correlation coefficient was used to determine the relationship between BDNF and lactate concentration at pre- and post-exercise, and change in concentration (post- minus pre-exercise). The Val66Met polymorphism was identified in 11 participants (35%, seven females). An increase in BDNF and lactate concentration was observed from pre- to post-exercise (<i>p</i> < 0.001), but no significant correlation between the two measures was observed at pre-exercise (<i>r</i> = −0.256, <i>p</i> = 0.164), post-exercise (<i>r</i> = 0.112, <i>p</i> = 0.549), and change in concentration (<i>r</i> = 0.019, <i>p</i> = 0.921). A moderate inverse correlation was observed in participants with the Val66Met polymorphism (<i>r</i> = −0.744, <i>p</i> = 0.009) and males (<i>r</i> = −0.695, <i>p</i> = 0.006) at pre-exercise. The results show that while BDNF and lactate concentrations increased following a submaximal graded exercise test, there is little evidence to suggest a relationship exists between BDNF and lactate.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Changes of Cingulate Gyrus Function and Perfusion in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis 抗n -甲基- d -天冬氨酸受体脑炎患者扣带回功能和血流灌注的特点及变化

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-24 DOI: 10.1002/jnr.70056

Yuanyuan Guo, Yue Zhao, Chenglong Li, Juanjuan Zhang, Ling Wei, Qiang Wei, Nong Zhou, Kai Wang, Yanghua Tian

{"title":"Characteristics and Changes of Cingulate Gyrus Function and Perfusion in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis","authors":"Yuanyuan Guo, Yue Zhao, Chenglong Li, Juanjuan Zhang, Ling Wei, Qiang Wei, Nong Zhou, Kai Wang, Yanghua Tian","doi":"10.1002/jnr.70056","DOIUrl":"https://doi.org/10.1002/jnr.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune condition associated with neuropsychiatric and cognitive deficits. Changes in the cingulate cortex may be central to this disorder. This study investigates subregional alterations in the cingulate cortex of patients with anti-NMDAR encephalitis and their relationship to cognitive deficits using functional and perfusion imaging. Thirty-eight patients with anti-NMDAR encephalitis and 30 healthy controls (HC) underwent resting-state MRI and neuropsychological assessments. We measured low-frequency amplitude (fALFF), degree centrality (DC), and cerebral blood flow (CBF) in the cingulate cortex, and performed functional connectivity (FC) and CBF connectivity analyses. We also analyzed the relationship between subregional changes and cognitive impairment. Finally, we applied support vector machines (SVM) to classify patients and controls based on functional and perfusion features. Patients with anti-NMDAR encephalitis showed significant cognitive impairments in memory and executive function, along with anxiety symptoms. Neuroimaging revealed decreased fALFF, DC, and CBF in the left pregenual anterior cingulate cortex (pgACC.L). FC between pgACC.L and several brain regions, including the parahippocampal gyrus and precuneus, was reduced. Additionally, pgACC.L exhibited altered CBF connectivity patterns with other brain regions. Moreover, the changes of fALFF, DC, and FC are related to the impaired cognitive function of patients. SVM classification based on fALFF, DC, and CBF features successfully distinguished patients from controls. Our findings suggest that pgACC abnormalities play a key role in the pathomechanism of anti-NMDAR encephalitis and may serve as biomarkers for disease monitoring.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice 白藜芦醇对小鼠颅内动脉瘤破裂的保护作用

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-23 DOI: 10.1002/jnr.70059

Dung Ngoc Phuong Dang, Yoshinobu Kamio, Toru Kawakatsu, Hiroshi Makino, Kazuya Hokamura, Ryo Imai, Yasuhito Suzuki, Hisaya Hiramatsu, Liu Zhitong, Kazuo Umemura, Kazuhiko Kurozumi

{"title":"Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice","authors":"Dung Ngoc Phuong Dang, Yoshinobu Kamio, Toru Kawakatsu, Hiroshi Makino, Kazuya Hokamura, Ryo Imai, Yasuhito Suzuki, Hisaya Hiramatsu, Liu Zhitong, Kazuo Umemura, Kazuhiko Kurozumi","doi":"10.1002/jnr.70059","DOIUrl":"https://doi.org/10.1002/jnr.70059","url":null,"abstract":"<div>\u0000 \u0000 <p>Resveratrol is a polyphenol and potent antioxidant that has anti-inflammatory effects in conditions such as atherosclerosis, aortic aneurysm, and inflammatory bowel disease. In this study, we investigated whether resveratrol exerts anti-inflammatory effects and protects against intracranial aneurysm formation and rupture in male mice. Intracranial aneurysms were induced in mice using a combination of elastase injection into the cerebrospinal fluid and deoxycorticosterone acetate-salt (DOCA-salt)-induced hypertension. Male mice were divided into two groups: a resveratrol diet group and a normal diet group. The dietary intervention lasted for 6 weeks, starting 3 weeks prior to elastase injection. The overall incidence of aneurysms did not differ significantly between the normal diet and resveratrol diet groups (71% vs. 59%, <i>p</i> = 0.497). However, resveratrol significantly reduced the rate of aneurysmal rupture compared with that in the normal diet group (88% vs. 40%, <i>p</i> = 0.026). Furthermore, resveratrol supplementation increased the mRNA levels of Sirtuin 1 (<i>Sirt1</i>) and decreased the mRNA levels of nuclear factor kappa B subunit 1 (<i>Nfkb1</i>) and Tumor necrosis factor (<i>Tnf</i>). Our findings demonstrate that resveratrol reduces intracranial aneurysm rupture in a mouse model, indicating its therapeutic potential in this condition.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0