Journal of Neuroscience Research最新文献_第2页

RETRACTION: Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model 撤稿：共病抑郁症和超重/肥胖的异常动态网络连接变化：来自三重网络模型的见解

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2025-08-01 DOI: 10.1002/jnr.70074

{"title":"RETRACTION: Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model","authors":"","doi":"10.1002/jnr.70074","DOIUrl":"https://doi.org/10.1002/jnr.70074","url":null,"abstract":"\u0000 RETRACTION: Zhang, Z.-Q., Liao, D., Guo, Z.-P., Song, S.-S., and Liu, X.-J. Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model. Journal of Neuroscience Research 102, no. 12 (2024): e70001, https://doi.org/10.1002/jnr.70001.\u0000 The above article, published online on 29 November 2024 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Lawrence S. Sherman; and Wiley Periodicals, LLC. The retraction has been agreed upon after the authors informed the editors that their findings on dynamic functional network connectivity, as presented in Figures 3-7, were not adequately independently validated, thereby undermining the reliability and reproducibility of the results. Furthermore, their ethical approval process was not fully compliant with the standard guidelines. The corresponding author contacted the journal and asked for a retraction, but the authors did not respond when asked to agree to the final retraction wording. The editors consider the results and conclusion of this article to be invalid.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nonhuman Primate Model to Evaluate Treatments for Long-Gap Ulnar Nerve Injury 非人灵长类动物模型评价尺神经长间隙损伤治疗方法

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-31 DOI: 10.1002/jnr.70069

Robert B. Shultz, Franco A. Laimo, Hannah H. Lee, Zarina S. Ali, Ryan Huang, Roy E. Barnewall, Carolyn G. Fetzek, Harry C. Ledebur, D. Kacy Cullen, Kritika S. Katiyar

{"title":"A Nonhuman Primate Model to Evaluate Treatments for Long-Gap Ulnar Nerve Injury","authors":"Robert B. Shultz, Franco A. Laimo, Hannah H. Lee, Zarina S. Ali, Ryan Huang, Roy E. Barnewall, Carolyn G. Fetzek, Harry C. Ledebur, D. Kacy Cullen, Kritika S. Katiyar","doi":"10.1002/jnr.70069","DOIUrl":"https://doi.org/10.1002/jnr.70069","url":null,"abstract":"<div>\u0000 \u0000 Among all upper extremity nerves, the ulnar nerve is both the most commonly injured and notoriously difficult to regenerate. Despite this, ulnar nerve injuries remain understudied. Nonhuman primates (NHPs) offer an ideal model for the human upper extremity, but existing NHP nerve trauma literature is biased towards median and radial injury models. To address this, a nonhuman primate ulnar nerve injury model was developed and regeneration assessed following sural nerve autografting using electrophysiological and histological techniques. Unilateral 4 cm ulnar nerve injuries were created at the mid-forearm level, sural nerve autografts were sutured into resulting defects (n = 3), and animals were survived for 6 months. At the terminal time point, intraoperative electrophysiological testing, tissue harvest, and tissue processing were performed. Naïve nerves (n = 5) served as controls. Animals appeared clinically normal throughout the study period, other than an expected decrease in fine hand muscle function. After 6 months, histological and electrophysiological evidence suggested that axons crossed the graft and reached distal muscle targets. However, regenerating nerves exhibited a reduced motor nerve conduction velocity, reduced compound action muscle potential (CMAP) amplitude and area under the curve, increased latency, and increased duration versus naïve controls as expected. Histological analysis revealed reduced axon diameters, thinner myelin sheaths, and smaller muscle fiber cross-sectional areas as compared to controls. At 6 months post-injury, 4 cm ulnar defects bridged with sural autografts show signs of ongoing regeneration and nascent reinnervation. Specific electrophysiological and histological benchmarks for ulnar nerve recovery following clinically relevant autografting are presented.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic Profiling Reveals Injury Responses of Peripheral Glial Cells in Sensory Neuron Microenvironment 转录组学分析揭示感觉神经元微环境中外周胶质细胞的损伤反应

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-29 DOI: 10.1002/jnr.70072

Jiacheng Xu, Jiaxin Jin, Saizhen Lv, Yanyu Pan, Dong Wang, Nimei Shen, Youhua Wang

{"title":"Transcriptomic Profiling Reveals Injury Responses of Peripheral Glial Cells in Sensory Neuron Microenvironment","authors":"Jiacheng Xu, Jiaxin Jin, Saizhen Lv, Yanyu Pan, Dong Wang, Nimei Shen, Youhua Wang","doi":"10.1002/jnr.70072","DOIUrl":"https://doi.org/10.1002/jnr.70072","url":null,"abstract":"<div>\u0000 \u0000 Schwann cells and satellite glial cells (SGCs) are important peripheral glial cells in the dorsal root ganglion (DRG) and commendable participants in regulating neuronal functions. Herein, through re-analysis of publicly available single-nucleus RNA sequencing data from naïve and injured DRG at 1 and 3 days following sciatic nerve crush, we systematically characterized the transcriptomic alterations in Schwann cells and SGCs. Cell clustering and counting showed that peripheral glial cells occupied a large population after sciatic nerve crush injury. Using differentially expression analysis, we found that apoptosis and immune responses were involved in all these examined peripheral glial cells. Unique glial cells also responded differently to sciatic nerve crush injury, with myelinating Schwann cells characterized by enriched adenosine 5′-monophosphate activated protein kinase (AMPK) metabolic signaling, non-myelinating Schwann cells characterized by enriched tissue-remodeling-related signaling, and SGCs characterized by enriched ion channels. Using single-cell regulatory network inference and clustering (SCENIC) to determine essential transcription factors in specific cell type at the naïve state and at multiple time points after sciatic nerve crush injury, we found that Schwann cells and SGCs possessed their own elevated transcription factor-coding genes, with activating factor 3 (Atf3) commonly highly up-regulated in all peripheral glial cells. This study provides a profiling map of peripheral glial cells at the naïve and injured states, expands the acknowledgment of the molecular background of nerve injury, and can lead to novel strategies to promote sensory nerve regeneration.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-Vivo 1H-MR Spectroscopy Investigation 脊髓损伤后运动系统的代谢和结构改变：体内1H-MR光谱研究

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-24 DOI: 10.1002/jnr.70071

Simon Schading-Sassenhausen, Anna Lebret, Kadir Şimşek, Pauline Gut, Sabrina Imhof, Björn Zörner, Roland Kreis, Patrick Freund, Maryam Seif

{"title":"Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-Vivo 1H-MR Spectroscopy Investigation","authors":"Simon Schading-Sassenhausen, Anna Lebret, Kadir Şimşek, Pauline Gut, Sabrina Imhof, Björn Zörner, Roland Kreis, Patrick Freund, Maryam Seif","doi":"10.1002/jnr.70071","DOIUrl":"https://doi.org/10.1002/jnr.70071","url":null,"abstract":"Spinal cord injury (SCI) disrupts spinal tracts and neuronal pathways, including those in the primary motor cortex (M1) and the lumbar cord enlargement (LCE) involved in motor control. This study sought to determine whether metabolite concentrations deviate between SCI and healthy controls (HC) in M1 and LCE using proton magnetic resonance spectroscopy (1H-MRS) and structural MRI, and if these correlate with clinical impairment. Sixteen chronic SCI (mean age: 54.7 ± 14.8y) and 19 HCs (mean age: 53.2 ± 18.8y) underwent 1H-MRS to quantify metabolites along with T1- and T2*-weighted MRI to assess tissue structural changes. Associations between metabolic and structural changes and clinical impairment were also assessed. Patients showed significant atrophy in both white matter of the LCE (HC: 37.7 ± 4.7 mm2, SCI: 33.9 ± 3.7 mm2, Δ = −10.1%, p = 0.015) and gray matter (HC: 20.9 ± 2.1 mm2, SCI: 19.4 ± 1.5 mm2, Δ = −7.2%, p = 0.022). Total N-acetylaspartate (tNAA) with respect to total creatine (tCr) was reduced in M1 of SCI (HC: 1.94 ± 0.21, SCI: 1.77 ± 0.14, ∆ = −8.8%, p = 0.006) and in the LCE (HC: 2.48 ± 0.76, SCI: 1.81 ± 0.80, ∆ = −27.0%, p = 0.02). In conclusion, reduced tNAA/tCr in both the atrophied LCE and M1 suggests widespread neuronal changes including cell atrophy and/or cell loss after injury. These findings provide in vivo evidence for retrograde and trans-synaptic neurodegeneration, which may underline the atrophy observed in the motor system in SCI. Ultimately, this highlights the potential for metabolic and structural biomarkers to improve the monitoring of subtle neurodegeneration following SCI and to enhance future regenerative treatment strategies.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden Markov Model-Based Behavioral Classification Reveals Visual Function Recovery After Retinal Organoid Transplantation in Mice 基于隐马尔可夫模型的行为分类揭示类视网膜器官移植后小鼠视觉功能恢复

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-23 DOI: 10.1002/jnr.70068

Hironobu Shuto, Michiko Mandai, Takayuki Yamada, Junki Sho, Chihiro Hayakawa, Chieko Koike, Masayo Takahashi, Take Matsuyama

{"title":"Hidden Markov Model-Based Behavioral Classification Reveals Visual Function Recovery After Retinal Organoid Transplantation in Mice","authors":"Hironobu Shuto, Michiko Mandai, Takayuki Yamada, Junki Sho, Chihiro Hayakawa, Chieko Koike, Masayo Takahashi, Take Matsuyama","doi":"10.1002/jnr.70068","DOIUrl":"https://doi.org/10.1002/jnr.70068","url":null,"abstract":"Retinal degenerative diseases cause irreversible vision loss due to photoreceptor degeneration. Retinal organoid transplantation offers a promising strategy for restoring vision, but assessing functional recovery remains challenging. Standard visual function tests provide binary or coarse measures that do not fully capture how visual input influences natural behavior. Here, we applied a Hidden Markov Model (HMM)-based behavioral analysis to the visual cliff test to track locomotor state transitions in wild-type (WT) and rd1-2 J (RD) mice, evaluating depth perception and its recovery following photoreceptor transplantation. WT mice exhibited a strong cliff avoidance response, while RD mice showed no response, confirming the model's sensitivity to depth perception. Over repeated trials, WT mice rapidly habituated, shifting from three behavioral states (Resting, Exploring, and Navigating) to just two (Resting and Navigating). Transplanted RD mice began responding to the cliff at 2 weeks posttransplantation, coinciding with early synapse formation between grafted photoreceptors and host bipolar cells. The avoidance response became robust by 16 weeks but disappeared by 18 weeks, accompanied by state collapse, a hallmark of habituation never observed in untreated RD mice. These findings demonstrate that behavioral state-based analysis provides a sensitive and dynamic measure of functional vision recovery, capturing not only the emergence of depth perception but also its integration into adaptive behavior. This approach may help refine clinical evaluations of vision restoration therapies, bridging the gap between sensory recovery and real-world functional outcomes.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia 发展性计算障碍儿童数字脑有效连通性的改变

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-21 DOI: 10.1002/jnr.70066

Simone Schwizer Ashkenazi, Ursina McCaskey, Ruth O’Gorman Tuura, Karin Kucian

{"title":"Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia","authors":"Simone Schwizer Ashkenazi, Ursina McCaskey, Ruth O’Gorman Tuura, Karin Kucian","doi":"10.1002/jnr.70066","DOIUrl":"https://doi.org/10.1002/jnr.70066","url":null,"abstract":"Numerical-order ability, a strong predictor of arithmetic, is often impaired in children with developmental dyscalculia (DD). While previous research has shown altered brain responses in number-processing regions in DD compared to typically developing children (TD), little is known about how these regions interact during number processing. This exploratory study examined the effective connectivity between six regions in the right parietal, frontal, and insular cortex as well as the vermis, using dynamic causal modeling (DCM). We investigated how number-order and number-identification tasks modulate connectivity within this network and the group differences related to DD. The number-order task led primarily to increased excitatory connectivity from the pre-supplementary motor area (preSMA) to all other regions, indicating an orchestrating role of the preSMA. DD, who exhibited deficits in number-order performance, demonstrated aberrant modulation of incoming connectivity to the ventral premotor cortex (vPMC) from the anterior intraparietal sulcus (aIPS), the preSMA, and the dorsal anterior insula (d-aINS). In TD, number-identification led to inhibitory modulation from the vPMC to the aIPS and the vermis. While behavioral performance in number-identification was unimpaired in DD, they showed increased excitatory connectivity from dorsal and ventral PMC to the d-aINS and from vPMC to the aIPS. Our results imply that, for both impaired and unimpaired number-related behavioral performance, neuronal number processing differs between DD and TD. This conclusion is further supported by the high predictive validity of the modulating connectivity group-effect parameters. We suggest the underlying explanation for this pattern may be related to decreased acuity of neuronal number representation in DD.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piano Training Induces Dynamic Neuroplasticity of Bimanual Coordination but Not Auditory Processing in Young Adults 钢琴训练诱导青少年双手协调的动态神经可塑性，但对听觉加工无影响

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-12 DOI: 10.1002/jnr.70067

Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Katarzyna Jednoróg, Artur Marchewka, Aleksandra M. Herman

{"title":"Piano Training Induces Dynamic Neuroplasticity of Bimanual Coordination but Not Auditory Processing in Young Adults","authors":"Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Katarzyna Jednoróg, Artur Marchewka, Aleksandra M. Herman","doi":"10.1002/jnr.70067","DOIUrl":"https://doi.org/10.1002/jnr.70067","url":null,"abstract":"<div>\u0000 \u0000 Piano training enables the study of the interplay between the auditory and motor domains in the acquisition of complex skill. Here, we uniquely combine longitudinal and cross-sectional designs to show how the motor and auditory brain systems respond in novice pianists over a 6-month training period. In the auditory domain, we found no differences in brain activation between novice pianists and a passive control group. In a specially designed piano task on an MRI-compatible keyboard, we demonstrate that the time course of neuroplastic reorganization in the cortical and subcortical regions reflects the shift from spatial attention to automated movements, but depends on task demands related to bimanual coordination. Importantly, no single model of brain plasticity can fully explain the observed dynamic time courses of functional changes. Finally, we demonstrate that the increased activation in the dorsal premotor and parietal cortices in novice pianists compared to skilled musicians while performing the motor task vanishes within the first 6 months of training. These results present converging evidence that the dynamic musical-training-related plasticity is highly contextual, and underscore the importance of ecological designs in research on skill acquisition.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Nerve Repair: Historical Perspectives, Current Advances, and Future Directions in Natural and Synthetic Neural Conduits 周围神经修复：自然和合成神经导管的历史观点、当前进展和未来方向

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-08 DOI: 10.1002/jnr.70060

Tayebeh Sadat Tabatabai, Morteza Alizadeh, Mohammad Kamalabadi Farahani, Arian Ehterami, Shahin Gharedaghi Kloucheh, Majid Salehi

{"title":"Peripheral Nerve Repair: Historical Perspectives, Current Advances, and Future Directions in Natural and Synthetic Neural Conduits","authors":"Tayebeh Sadat Tabatabai, Morteza Alizadeh, Mohammad Kamalabadi Farahani, Arian Ehterami, Shahin Gharedaghi Kloucheh, Majid Salehi","doi":"10.1002/jnr.70060","DOIUrl":"https://doi.org/10.1002/jnr.70060","url":null,"abstract":"<div>\u0000 \u0000 Regenerative medicine aims to restore damaged tissues or organs using stem cells, biomaterials, and decellularized grafts. Peripheral nerve injuries (PNI), affecting 2.8% of patients, lead to severe functional impairments with global socioeconomic costs exceeding $7 billion annually. Despite advancements in surgical techniques, full functional recovery remains elusive, particularly in critical gap injuries (> 3 cm). Autografts remain the gold standard but are hindered by donor tissue scarcity and complications like neuroma formation. Allografts face challenges due to the lack of Schwann cells and neurotrophic support. Emerging approaches in tissue engineering leverage synthetic materials, such as polycaprolactone (PCL) and polylactic acid (PLA), and biological scaffolds like decellularized nerve grafts. These innovations provide structural support, promote axonal regeneration, and retain extracellular matrix components, enabling cell adhesion and migration while minimizing antigenicity. However, barriers such as mechanical instability, scar tissue formation, and inadequate cellularization persist. This review explores the anatomy and clinical significance of the sciatic nerve, historical perspectives on peripheral nerve repair, and current treatment strategies. It evaluates biological and synthetic nerve conduits, highlighting FDA-approved products and their advantages in promoting nerve regeneration. Additionally, the paper discusses challenges in the field, including limited functional recovery and the need for more effective clinical solutions. By combining natural and synthetic materials with growth factor delivery and vascularization strategies, engineered scaffolds hold promise for improving outcomes in PNI repair. Further research is essential to optimize these technologies and bridge existing gaps in clinical practice.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Prevents Neuronal Loss and Inhibits Development of Spontaneous Recurrent Seizures via the PPARγ/PTEN/Akt Pathway in Chronic Epilepsy 姜黄素通过PPARγ/PTEN/Akt通路预防慢性癫痫的神经元丢失和抑制自发性复发性癫痫发作

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-04 DOI: 10.1002/jnr.70064

Sun Hong, Liu GuoYan, Wu JiaWen, Yu Xin, Zhan ShuQin, Reng HongWei, Chen MengYing, Cheng YuXuan

{"title":"Curcumin Prevents Neuronal Loss and Inhibits Development of Spontaneous Recurrent Seizures via the PPARγ/PTEN/Akt Pathway in Chronic Epilepsy","authors":"Sun Hong, Liu GuoYan, Wu JiaWen, Yu Xin, Zhan ShuQin, Reng HongWei, Chen MengYing, Cheng YuXuan","doi":"10.1002/jnr.70064","DOIUrl":"https://doi.org/10.1002/jnr.70064","url":null,"abstract":"<div>\u0000 \u0000 Chronic epilepsy is mainly characterized by spontaneous recurrent seizures (SRS). The peroxisome proliferator activated receptor gamma/phosphatase and tensin homolog/protein kinase B (PPARγ/PTEN/Akt) pathway is involved in the pathogenesis of SRS and neuronal loss. Curcumin is a natural compound, and previous studies have shown it provides neuroprotection via anti-inflammation and anti-oxidant effects in many central nervous system (CNS) diseases. In the present study, we show that curcumin regulates the abnormal expression of PTEN and Akt in the SRS phase, improves the neuronal loss in the hippocampus, and suppresses SRS development and seizure spike activity in epileptic rats. More importantly, these effects are reversed by the PPARγ antagonist, T0070907, suggesting that curcumin exerts neuroprotective and anti-epileptic effects through the PPARγ/PTEN/Akt signaling pathway. Other studies have shown that curcumin can cross the BBB and has a safety profiles and pleiotropic pharmacological effects. Thus, our data support the proposition that curcumin might be a potential neuroprotective and anti-epileptic agent for chronic epilepsy.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P2X7R: A Critical Regulator and Potential Therapeutic Target for Glioma P2X7R：神经胶质瘤的关键调控因子和潜在治疗靶点

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-03 DOI: 10.1002/jnr.70065

Meng Yan, Ronglan Zhao, Yanwen Xue, Yahui Cao, Yanan Du, Xiaoxiang Peng

{"title":"P2X7R: A Critical Regulator and Potential Therapeutic Target for Glioma","authors":"Meng Yan, Ronglan Zhao, Yanwen Xue, Yahui Cao, Yanan Du, Xiaoxiang Peng","doi":"10.1002/jnr.70065","DOIUrl":"https://doi.org/10.1002/jnr.70065","url":null,"abstract":"<div>\u0000 \u0000 Glioma is the most common primary brain tumor, characterized by high invasiveness and poor prognosis. The purinergic ligand-gated ion channel 7 receptor (P2X7R), an ion channel-type purinergic receptor with adenosine triphosphate (ATP) as its ligand, is widely expressed in various tumor cells, including glioma. Moreover, it plays crucial biological functions in the progression of glioma. P2X7R promotes the proliferation, invasion, and metastasis of glioma by activating multiple signaling pathways, facilitating epithelial–mesenchymal transition (EMT), promoting the release of extracellular vesicles (EVs) and regulating the tumor microenvironment (TME) of glioma. However, the activation of P2X7R by high concentrations of ATP can induce cell necrosis or pyroptosis, exerting an anti-glioma effect. The bidirectional nature of its functions may be related to differences in the subtypes of P2X7R, cell types, as well as the TME. P2X7R antagonists can inhibit its effect in glioma, while the expression of P2X7R can enhance the efficacy of radiotherapy and chemotherapy. In this review, the structure and function of P2X7R, its role in tumor, especially its mechanism of action in glioma, and its latent capacity value as a target for therapeutic of glioma were reviewed in detail.\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0