Journal of Neuroscience Research最新文献_第2页

Sex Differences in Markers of Neuronal Adaptation in the Medullary Dorsal Horn During the Development of Orofacial Neuropathic Pain 颅面神经性疼痛发生过程中髓背角神经元适应标记物的性别差异。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-02-02 DOI: 10.1002/jnr.70117

Hyunsol Lim, James W. M. Kang, Luke A. Henderson, Kevin A. Keay

{"title":"Sex Differences in Markers of Neuronal Adaptation in the Medullary Dorsal Horn During the Development of Orofacial Neuropathic Pain","authors":"Hyunsol Lim, James W. M. Kang, Luke A. Henderson, Kevin A. Keay","doi":"10.1002/jnr.70117","DOIUrl":"10.1002/jnr.70117","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic trigeminal neuropathic pain is caused by a lesion, damage, or trauma to the trigeminal sensory system. The pain affects female individuals with higher incidence and greater severity compared with males. Despite a strong sex bias in this clinical condition, the majority of preclinical experimental studies of trigeminal neuropathic pain have been conducted in males. This study investigated sex differences in the number of ΔFosB and FosB immunoreactive cells, as markers of neuronal adaptation following infraorbital nerve chronic constriction injury (ION-CCI). Sex differences in ΔFosB and FosB expression were identified in infra-orbital recipient regions of laminae I-II of the medullary dorsal horn during the post-injury period. Three phases of altered expression were identified following ION-CCI: (1) an early phase 2 days after injury, (2) a transitional phase (7–14 days), and (3) a late phase (28+ days). Nerve-injured female rats had consistently lower levels of ΔFosB immunoreactive cells when compared with males and showed increased FosB expression during the early phase. In contrast, in males, the number of ΔFosB immunoreactive cells decreased significantly from the early phase to the transitional phase post-injury. However, by the late phase, ΔFosB expression in the superficial laminae of the medullary dorsal horn was significantly higher than in females. These data suggest that cellular adaptation in neurons in laminae I-II of the medullary dorsal horn in males is much greater than that in females, revealing one location at which the sex differences seen in the incidence and severity of trigeminal neuropathic pain might be mediated.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Marrow Mesenchymal Stem Cells Improve Cognitive Impairment Induced by Neuropathic Pain Through Blood CXCL12/CXCR4 Axis in Male Mice 骨髓间充质干细胞通过血液CXCL12/CXCR4轴改善雄性小鼠神经性疼痛诱导的认知障碍

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-28 DOI: 10.1002/jnr.70111

Kai Sun, Le Qi, Hao Zhang, Liwei Wang, Ting Zhang

{"title":"Bone Marrow Mesenchymal Stem Cells Improve Cognitive Impairment Induced by Neuropathic Pain Through Blood CXCL12/CXCR4 Axis in Male Mice","authors":"Kai Sun, Le Qi, Hao Zhang, Liwei Wang, Ting Zhang","doi":"10.1002/jnr.70111","DOIUrl":"10.1002/jnr.70111","url":null,"abstract":"<div>\u0000 \u0000 <p>Recent evidence has shown that bone marrow mesenchymal stem cells (BMSCs) have multiple biological applications and play an important role in improving cognitive dysfunction. However, it is still unclear whether BMSCs play a role in cognitive impairment induced by chronic pain. This study aimed to evaluate the therapeutic effect of BMSCs on neuropathic pain-induced cognitive dysfunction and explore its potential mechanisms. A mouse chronic constriction injury (CCI) model was established, and the new object recognition task and fear conditioning were used to detect cognitive function; the expression of CXCL12/CXCR4 in blood and hippocampus was detected. After intravenous injection of BMSCs, changes in cognitive function and expression of the CXCL12/CXCR4 pathway, dentate gyrus neurogenesis, and excitability of hippocampal neurons were detected. In addition, induction of cognitive impairment in normal mice by CXCL12 recombinant protein was used to clarify whether the CXCL12/CXCR4 pathway mediates the cognitive function improvement effect of BMSCs. Our results found CCI mice showed significant cognitive impairment 21 days after surgery, with significantly increased expression of CXCL12/CXCR4 in blood and hippocampus. Intravenous injection of BMSCs significantly improved cognitive function, inhibited expression of CXCL12/CXCR4 in blood and hippocampus, promoted neurogenesis in dentate gyrus of CCI mice, and increased expression of BDNF and c-Fos in the hippocampus. In addition, BMSCs alleviate cognitive impairment induced by intravenous injection of CXCL12 recombinant protein in mice. In summary, BMSCs improve chronic neuropathic pain-induced cognitive dysfunction through peripheral blood CXCL12/CXCR4, and BMSCs may develop into therapeutic targets for chronic pain induced cognitive impairment.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Identification of Mitochondrial-Related Biomarkers of Ruptured Intracranial Aneurysms Based on Bioinformatics Analysis and Machine Learning 基于生物信息学分析和机器学习的颅内动脉瘤破裂线粒体相关生物标志物鉴定。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-26 DOI: 10.1002/jnr.70114

Yao Li, Dezhang Huang, Zeyu Wu, Tao Liu, Peng Sun

{"title":"The Identification of Mitochondrial-Related Biomarkers of Ruptured Intracranial Aneurysms Based on Bioinformatics Analysis and Machine Learning","authors":"Yao Li, Dezhang Huang, Zeyu Wu, Tao Liu, Peng Sun","doi":"10.1002/jnr.70114","DOIUrl":"10.1002/jnr.70114","url":null,"abstract":"<div>\u0000 \u0000 <p>Intracranial aneurysms (IAs) are pathological dilatations of cerebral blood vessels, and their rupture can lead to severe mortality and disability. Therefore, identifying those at risk of rupture is of considerable clinical significance. We screened 3740 differentially expressed genes (DEGs) in ruptured IA (RIA) versus unruptured IA (UIA) from the GSE13353 dataset. Weighted gene co-expression network analysis (WGCNA) was used to identify RIA-related module genes. After the intersection of DEGs and module genes with mitochondria-related genes (MRGs), MTX1, BCL2A1, BID, UCP2, ME2, VAV1, CYBA, and CYBB were identified as mitochondria-associated signatures of RIA. MTX1 was identified as the key diagnostic biomarker using three machine learning methods. While the diagnostic potential of this eight-gene signature was supported by an independent dataset (GSE122897), experimental validation in clinical and animal models confirmed significant dysregulation of ME2, UCP2, BCL2A1, and CYBA in RIA. Notably, MTX1 showed a consistent but non-significant trend of downregulation in these experimental assays. Immune infiltration analysis revealed a pro-inflammatory and stromal-enriched microenvironment in RIA, characterized by significantly elevated abundances of fibroblasts, smooth muscle cells, and macrophages, and showing distinct correlation patterns between key mitochondrial genes and specific immune and stromal cell populations. The construction of transcription factors and endogenous RNA networks was used to identify the underlying molecular mechanisms. Finally, potential therapeutic drugs such as rosiglitazone were identified by drug prediction, and the molecular docking of ME2 with cryptotanshinone suggested a new therapeutic approach. This study may provide a new strategy for the diagnosis and treatment of RIA targeting mitochondria.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Inhibition of EZH2 by GSK-343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury GSK-343对EZH2的药理抑制减轻脊髓损伤小鼠模型的神经炎症

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-20 DOI: 10.1002/jnr.70104

Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici, Bulzomì Maria, Ahmed Hasan, Antonio Catalfamo, Jia Yang, Marika Lanza, Alessia Filippone

{"title":"Pharmacological Inhibition of EZH2 by GSK-343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury","authors":"Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici, Bulzomì Maria, Ahmed Hasan, Antonio Catalfamo, Jia Yang, Marika Lanza, Alessia Filippone","doi":"10.1002/jnr.70104","DOIUrl":"10.1002/jnr.70104","url":null,"abstract":"<p>Spinal cord injury (SCI) is a devastating condition with limited therapeutic options and a strong neuroinflammatory component that exacerbates tissue damage and impairs functional recovery. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and core component of the Polycomb Repressive Complex 2 (PRC2), has emerged as a key regulator of epigenetic modifications involved in neuroinflammation. In this study, we investigated the potential neuroprotective effects of GSK-343, a selective EZH2 inhibitor, in a murine model of SCI induced by extradural compression. Female adult CD1 mice received intraperitoneal injections of GSK-343 (1, 5, or 10 mg/kg) at 1- and 6-h post-injury. After 24 h, spinal cord tissues were collected and analyzed. GSK-343 treatment significantly reduced histological damage, neuronal demyelination, and the expression of pro-inflammatory markers, likely through modulation of the TRAF6/NF-κB signaling pathway. Moreover, EZH2 inhibition attenuated innate immune responses, as evidenced by the reduction in mast cell infiltration, microglial activation, and MCP-1 levels. These findings support the therapeutic potential of EZH2 inhibition as a novel epigenetic strategy to counteract neuroinflammation and promote early neuroprotection following SCI.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix 功能性附睾淀粉样半胱抑素相关附睾生精（CRES）是哺乳动物脑细胞外基质的一个组成部分。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-20 DOI: 10.1002/jnr.70113

Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall

{"title":"The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix","authors":"Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall","doi":"10.1002/jnr.70113","DOIUrl":"10.1002/jnr.70113","url":null,"abstract":"<p>CRES is the defining member of a reproductive subgroup of family 2 cystatins of cysteine protease inhibitors. We previously showed that CRES and other subgroup members are part of a highly plastic amyloid-containing extracellular matrix (ECM) with host defense functions in the mouse epididymal lumen. Based on parallels between the epididymis and the brain, we hypothesized that CRES and CRES amyloids might also function within the brain including the ECM. Here we show that CRES is produced by hippocampal neurons and astrocytes in the male and female mouse and human brain. Further, approximately 50% of hippocampal astrocytes from aged mice, like the aged human donor samples, had significantly reduced levels of CRES compared to younger mice, suggesting an age-related decline in CRES could contribute to altered brain function. Immunofluorescence experiments showed CRES colocalized with the ECM markers phosphacan and <i>wisteria floribunda</i> agglutinin indicating that CRES is part of the ECM. CRES monomer and high molecular weight SDS-resistant forms were found in insoluble fractions of the hippocampus, cortex, cerebellum, and midbrain and bound to the protein aggregation disease (PAD) ligand, which preferentially binds amyloids but not protein monomers, suggesting a population of CRES normally exists in the brain as an amyloid structure. Collectively, our studies demonstrate that CRES/CRES amyloid is present in the mammalian brain and may contribute to ECM structure and function.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Mammalian Models in Ischemic Stroke Research: Advances, Applications, and Translational Potential 缺血性卒中研究中的非哺乳动物模型：进展、应用和转化潜力。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-20 DOI: 10.1002/jnr.70112

Takamasa Mizoguchi, Ayako Tonoki, Atsushi Yamaguchi, Motoyuki Itoh

{"title":"Non-Mammalian Models in Ischemic Stroke Research: Advances, Applications, and Translational Potential","authors":"Takamasa Mizoguchi, Ayako Tonoki, Atsushi Yamaguchi, Motoyuki Itoh","doi":"10.1002/jnr.70112","DOIUrl":"10.1002/jnr.70112","url":null,"abstract":"<div>\u0000 \u0000 <p>Ischemic stroke remains a major global health burden, consistently ranking among the leading causes of mortality and long-term disability. Although rodent models are widely utilized for ischemic stroke research, their limited translational success has driven the pursuit of alternative experimental systems. This review underscores the growing significance of non-mammalian models, particularly <i>zebrafish</i> and <i>Drosophila melanogaster</i>, in advancing ischemic stroke research. Zebrafish offer notable advantages, including high genetic homology with humans, optical transparency, a pronounced capacity for neural regeneration, in vivo live real-time imaging, and behavioral analyses. Photothrombotic and systemic hypoxia paradigms in zebrafish enable detailed investigation of neurovascular injury and recovery processes. <i>Drosophila</i>, characterized by a rapid life cycle and sophisticated genetic toolkit, serves as a valuable model for elucidating hypoxia-induced neuronal damage and stroke-related comorbidities such as sleep disturbances. These models are cost-efficient, ethically advantageous, and well-suited for high-throughput applications. Despite inherent anatomical and physiological disparities, non-mammalian systems provide critical complementary insights into stroke pathogenesis and therapeutic innovation, reinforcing their integration into multi-model research frameworks.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons G蛋白偶联受体激酶5 （GRK5）调节大鼠交感神经元痛觉肽/孤啡肽FQ阿片受体脱敏。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-13 DOI: 10.1002/jnr.70110

Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz-Velasco

{"title":"G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons","authors":"Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz-Velasco","doi":"10.1002/jnr.70110","DOIUrl":"10.1002/jnr.70110","url":null,"abstract":"<p>Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage-gated Ca<sup>2+</sup> channel inhibition or G protein inwardly rectifying K<sup>+</sup> channel activation. One mechanism of G protein-coupled receptor (GPCR) desensitization occurs when G protein-coupled receptor kinases (GRK) phosphorylate the agonist-bound receptors. In the continued presence of an agonist, Gβγ recruits GRK to the plasma membrane where GPCR are then phosphorylated by GRK. The purpose of this study was to identify the GRK subtype responsible for desensitization of the Noc-mediated Ca<sup>2+</sup> current inhibition in rat stellate ganglion (SG) neurons. We observed that GRK2 and GRK5 are expressed in SG neurons. Further, silencing either GRK subtype alone or together employing siRNA did not overtly alter their Noc pharmacological profile. We assessed NOP receptor desensitization employing a protocol where the peak Ca<sup>2+</sup> current inhibition was measured during intermittent application of high Noc concentrations in the continued presence of the IC<sub>50</sub> Noc concentration. With this approach, we observed complete Ca<sup>2+</sup> current desensitization in neurons transfected with either scrambled or GRK2 siRNA following exposure to high Noc concentrations. On the other hand, full desensitization of the Ca<sup>2+</sup> currents was not observed in neurons in which GRK5 was silenced alone or with GRK2. That is, coupling of NOP receptors with Ca<sup>2+</sup> channels was still observed following application of high Noc concentration. These results suggest that GRK5 plays a key role in the mechanism that mediates NOP receptor desensitization in SG neurons.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Subcellular Localization of the Cystic Fibrosis Transmembrane Conductance Regulator in the Chicken Retina Suggests Multiple Roles in Retinal Function 鸡视网膜中囊性纤维化跨膜传导调节因子的亚细胞定位提示其在视网膜功能中的多重作用。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-09 DOI: 10.1002/jnr.70109

Brandon Leviskas, Evanna Gleason

{"title":"The Subcellular Localization of the Cystic Fibrosis Transmembrane Conductance Regulator in the Chicken Retina Suggests Multiple Roles in Retinal Function","authors":"Brandon Leviskas, Evanna Gleason","doi":"10.1002/jnr.70109","DOIUrl":"10.1002/jnr.70109","url":null,"abstract":"<div>\u0000 \u0000 <p>Protein function is influenced by multiple factors including cell type and subcellular localization. The cystic fibrosis transmembrane conductance regulator (CFTR) is well investigated in epithelial tissues, where life threatening symptoms stem from its dysfunction. A postsynaptic neuronal role was previously established by the Gleason lab where CFTR regulation of cytosolic Cl<sup>–</sup> in retinal amacrine cells was shown. Other work from our lab showed that disruption of the synaptic vesicle cycle reduced action of CFTR, suggesting CFTR associates with synaptic vesicles. Here, we evaluate the hypothesis that CFTR localizes to the synapse with possible presynaptic function. To address this, the cellular and subcellular CFTR localization in mature chicken retina was examined using fluorescence light microscopy and immunogold-labeled transmission electron microscopy. CFTR labeling was detected throughout the retina, including photoreceptor outer segments and in the mitochondria rich region of the photoreceptor inner segment termed the ellipsoid. Synaptic labeling was found in both synaptic plexiform layers, pre-and post-synaptically. A subset of amacrine cells were strongly labeled and labeling was also found in Müller cells and in axons of the nerve fiber layer. Addressing whether the activity of CFTR plays a role in presynaptic function, amacrine cells were recorded using the whole cell voltage clamp method. Spontaneous postsynaptic quantal currents were recorded and found to increase in frequency upon pharmacological inhibition of CFTR suggesting that under normal circumstances, CFTR serves to limit the rate of spontaneous synaptic vesicle fusion. This work provides evidence CFTR might have multiple functions in the retina including synaptic transmission regulation.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tryptophan Hydroxylase: A Target for the Correction of Affective and Neurodegenerative Disorders 色氨酸羟化酶：纠正情感性和神经退行性疾病的靶标。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-06 DOI: 10.1002/jnr.70106

Valentina Mikhailovna Sviridova, Margarita Timurovna Absalyamova, Marina Nikolaevna Karpenko, Irina Sergeevna Ivleva

{"title":"Tryptophan Hydroxylase: A Target for the Correction of Affective and Neurodegenerative Disorders","authors":"Valentina Mikhailovna Sviridova, Margarita Timurovna Absalyamova, Marina Nikolaevna Karpenko, Irina Sergeevna Ivleva","doi":"10.1002/jnr.70106","DOIUrl":"10.1002/jnr.70106","url":null,"abstract":"<div>\u0000 \u0000 <p>Tryptophan hydroxylase (TPH) is a key enzyme in the biosynthesis of serotonin, a neurotransmitter involved in the regulation of mood, emotional state, sleep, appetite, digestion, and cognitive functions. It plays a key role in the creation of a sense of well-being, reduction of anxiety and control of the response to stress. Imbalances in its levels are associated with many disorders, notably depression, anxiety disorders and migraines. This review examines the structural and functional aspects of the regulation of TPH activity with an emphasis on its isoforms, TPH1 and TPH2, which are responsible for serotonin synthesis in peripheral tissues and in neurons, respectively. Approaches to TPH regulation at the gene, protein, and enzymatic activity levels are discussed. The role of TPH in the pathogenesis of affective disorders such as depression, anxiety, attention deficit hyperactivity disorder and posttraumatic stress disorder is also discussed. Approaches to modulating TPH activity are proposed, including, for example, using calpain inhibitors.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Magic Mushroom (Psilocybe azurescens) on Social Interaction, Anxiety- and Depressive-Like Behaviors in Male Rats; the Role of Neuroinflammation, Oxidative Stress, and Neurotrophic Factors 魔菇对雄性大鼠社会交往、焦虑和抑郁样行为的影响神经炎症、氧化应激和神经营养因子的作用。

IF 3.4 3区医学

Journal of Neuroscience Research Pub Date : 2026-01-06 DOI: 10.1002/jnr.70107

Hediye Moghadam, Parisa Akbari, Elmira Beirami, Samaneh Nabavifard, Akram Ameli, Neda Valian

{"title":"The Effect of Magic Mushroom (Psilocybe azurescens) on Social Interaction, Anxiety- and Depressive-Like Behaviors in Male Rats; the Role of Neuroinflammation, Oxidative Stress, and Neurotrophic Factors","authors":"Hediye Moghadam, Parisa Akbari, Elmira Beirami, Samaneh Nabavifard, Akram Ameli, Neda Valian","doi":"10.1002/jnr.70107","DOIUrl":"10.1002/jnr.70107","url":null,"abstract":"<div>\u0000 \u0000 <p>Psilocybin-containing mushrooms, commonly known as magic mushrooms, strongly affect mood, cognition, and behavior. <i>Psilocybe azurescens</i> is a species of psilocybin mushrooms that contains the main active compounds psilocybin and psilocin. Psilocybin mushrooms have been used since ancient times to improve the quality of life. However, their adverse effects have been less studied. This study aimed to investigate, for the first time, the effect of oral consumption of <i>P. azurescens</i> on social behavior, anxiety- and depressive-like behaviors in rats. The underlying mechanisms of these behaviors were also studied. Male Wistar rats received three doses of <i>P. azurescens</i> (10, 100, and 250 mg/kg) by gavage every other day for 14 days. Social interaction, anxiety- and depressive-like behaviors were assessed using the three-chamber, elevated plus maze, and forced swimming tests, respectively. Protein levels of neurotrophic (BDNF and GDNF), neuroinflammatory (IL-6 and TNFα), and oxidative stress (ROS and SOD) factors were measured in the hippocampus, prefrontal cortex (PFC), and amygdala by ELISA technique. The results showed that <i>P. azurescens</i> significantly increased anxiety- and depressive-like behaviors and disrupted social interaction behavior in rats. These effects were accompanied by increased neuroinflammation and oxidative stress and decreased neurotrophic factors in the hippocampus, PFC, and amygdala. This study suggests that the high doses of <i>P. azurescens</i> can cause mood disorders by increasing inflammatory responses and oxidative stress and decreasing the expression of neurotrophic factors.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"104 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0