Journal of Neuroscience Research最新文献_第3页

Unveiling the Neural Pathways of Empathic Pain: Implications for Modulation Strategies and Beyond 揭示共情疼痛的神经通路：对调节策略的启示及其他

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-07-01 DOI: 10.1002/jnr.70063

Yingying Zhang, Kun Zhang, Hengxin Gong, Minggao Zhao, Lanxin Luo

{"title":"Unveiling the Neural Pathways of Empathic Pain: Implications for Modulation Strategies and Beyond","authors":"Yingying Zhang, Kun Zhang, Hengxin Gong, Minggao Zhao, Lanxin Luo","doi":"10.1002/jnr.70063","DOIUrl":"https://doi.org/10.1002/jnr.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>Empathic pain, a core manifestation of empathy, encompasses an individual's perceptual sensitivity, evaluative judgment, and emotional responsiveness to the suffering of others. This capacity is vital for healthy social interaction, as it fosters prosocial behavior, inhibits aggression, and upholds moral norms critical to social development. This article provides a comprehensive review of current research on empathic pain, examining its conceptual foundations and the underlying neural mechanisms. In particular, it explores the activation of key brain regions, including the anterior cingulate cortex, insula, amygdala, and cerebellum, as well as the neural circuits linking these areas. Additionally, the paper summarizes various influencing factors and modulatory strategies related to empathic pain. These insights enhance our understanding of emotional resonance and establish a solid basis for developing clinical modulation models. Future research should adopt a multidisciplinary approach, incorporating advanced neuroimaging techniques, behavioral experiments, and broader clinical trials to further elucidate empathic pain and inform the development of more effective treatment strategies.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development 单神经元放电与癫痫发生和癫痫发展中的高频振荡动力学相关

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-30 DOI: 10.1002/jnr.70062

Xiaonan Li, Shipei He, Jiaoyang Wang, Guoyun Feng, Donghong Li, Yue Xing, Yu Yang, Wentao Dai, Jiaqing Yan, Xiaofeng Yang, Liemin Zhou

{"title":"Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development","authors":"Xiaonan Li, Shipei He, Jiaoyang Wang, Guoyun Feng, Donghong Li, Yue Xing, Yu Yang, Wentao Dai, Jiaqing Yan, Xiaofeng Yang, Liemin Zhou","doi":"10.1002/jnr.70062","DOIUrl":"https://doi.org/10.1002/jnr.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>The mechanism of epilepsy is still unclear. We aim to explore the relationship between high-frequency oscillations (HFOs) dynamics and epilepsy, with a focus on deciphering underlying mechanisms at the single-neuron level. Using a rat model of chronic focal cortical epilepsy induced by cobalt-wire implantation, we monitored the seizures and HFO dynamics, as well as the cross-frequency coupling trends between HFOs and theta activities. Additionally, excitatory and inhibitory neurons' discharges were recorded by 16-channel tetrode electrode, with comparisons made between the discharge rates and changes from baselines during different bands of HFOs (ripple:80-200 Hz; fast ripple, FRs:200-500 Hz). All rats (8/8) with cobalt-wire implantation developed spontaneous seizures within 4 to 8 days post-surgery, in contrast to the control group (3/3) with steel-wire insertion remaining seizure-free. HFOs exhibited a progressive increase over time post-surgery in the epilepsy model, while minimal HFOs was observed in the control group. HFOs recorded during the peak-seizure periods showed a propensity to synchronize with the trough of theta activity, coinciding with heightened seizure frequency. A substantial augmentation showed in the discharge rates of both putative excitatory and inhibitory neurons during HFO occurrences. The change ratios between putative excitatory and inhibitory neurons during ripples were smaller than those during FRs. In conclusion, we found that HFO dynamics reflect epileptogenic network formation, with implications for early seizure prediction and therapeutic interventions. Our data provide novel insights at cellular and cross-frequency level into the mechanistic underpinnings of HFO emergence and network reorganization offering potential strategies for targeting pathological network activity in epilepsy.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells 硫代氨基酸氯胺酮乙酯诱导小鼠少突胶质细胞祖细胞增殖成熟并调节钙通量

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-27 DOI: 10.1002/jnr.70061

Veronica T. Cheli, Swathi G. Tumuluri, Zachary McDonald, Travis T. Denton, Jeffrey L. Dupree, Pablo M. Paez, Douglas L. Feinstein

{"title":"Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells","authors":"Veronica T. Cheli, Swathi G. Tumuluri, Zachary McDonald, Travis T. Denton, Jeffrey L. Dupree, Pablo M. Paez, Douglas L. Feinstein","doi":"10.1002/jnr.70061","DOIUrl":"https://doi.org/10.1002/jnr.70061","url":null,"abstract":"<p>Previous studies have shown that lanthionine ketimine ethyl ester (LKE), a semi-synthetic derivative of the endogenous amino acid lanthionine, can induce proliferation and maturation of oligodendrocyte progenitor cells (OPCs) in vivo. In the current study, we examined the effects of LKE on Ca<sup>2+</sup> influx in primary mouse OPCs, as intracellular Ca<sup>2+</sup> can regulate those processes. Treatment with LKE stimulated proliferation of OPCs and increased the number of Olig2+, CC1+, and PLP+ cells. LKE also reduced cell death (caspase-3 expressing cells). Measurements of Ca<sup>2+</sup> flux showed that LKE increased basal Ca<sup>2+</sup> levels, reduced Ca<sup>2+</sup> influx following stimulation with glutamate or ATP, and increased Ca<sup>2+</sup> flux because of depolarization with KCl. Reduced Ca<sup>2+</sup> responses were also observed following treatment with a peptide that disrupts interactions of collapsin response mediated protein 2 (CRMP2), a primary target of LKE. These findings demonstrate regulation of Ca<sup>2+</sup> levels in OPCs by LKE and suggest that these actions may be mediated, in part, by CRMP2. LKE or related analogs could therefore be of benefit for the treatment of multiple sclerosis as well as other demyelinating conditions.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation 运动后脑源性神经营养因子和乳酸的增加并没有显示出直接的相关性

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-24 DOI: 10.1002/jnr.70058

S. K. Ashcroft, K. Basclain, C. Woolnough, M. W. Hoon, S. J. Walsh, L. C. Starc, L. Johnson, S. S. Kuys, A. G. Thompson-Butel

{"title":"Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation","authors":"S. K. Ashcroft, K. Basclain, C. Woolnough, M. W. Hoon, S. J. Walsh, L. C. Starc, L. Johnson, S. S. Kuys, A. G. Thompson-Butel","doi":"10.1002/jnr.70058","DOIUrl":"https://doi.org/10.1002/jnr.70058","url":null,"abstract":"<p>The aim of this study was to determine the relationship between BDNF and lactate concentration, accounting for genotype and sex, before and after a submaximal graded exercise test in 31 adults (37.5 ± 14.0 years, 54.8% female). The presence of the Val66Met polymorphism was identified at baseline, and BDNF and lactate concentrations were measured before and after exercise. Pearson's correlation coefficient was used to determine the relationship between BDNF and lactate concentration at pre- and post-exercise, and change in concentration (post- minus pre-exercise). The Val66Met polymorphism was identified in 11 participants (35%, seven females). An increase in BDNF and lactate concentration was observed from pre- to post-exercise (<i>p</i> < 0.001), but no significant correlation between the two measures was observed at pre-exercise (<i>r</i> = −0.256, <i>p</i> = 0.164), post-exercise (<i>r</i> = 0.112, <i>p</i> = 0.549), and change in concentration (<i>r</i> = 0.019, <i>p</i> = 0.921). A moderate inverse correlation was observed in participants with the Val66Met polymorphism (<i>r</i> = −0.744, <i>p</i> = 0.009) and males (<i>r</i> = −0.695, <i>p</i> = 0.006) at pre-exercise. The results show that while BDNF and lactate concentrations increased following a submaximal graded exercise test, there is little evidence to suggest a relationship exists between BDNF and lactate.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Changes of Cingulate Gyrus Function and Perfusion in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis 抗n -甲基- d -天冬氨酸受体脑炎患者扣带回功能和血流灌注的特点及变化

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-24 DOI: 10.1002/jnr.70056

Yuanyuan Guo, Yue Zhao, Chenglong Li, Juanjuan Zhang, Ling Wei, Qiang Wei, Nong Zhou, Kai Wang, Yanghua Tian

{"title":"Characteristics and Changes of Cingulate Gyrus Function and Perfusion in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis","authors":"Yuanyuan Guo, Yue Zhao, Chenglong Li, Juanjuan Zhang, Ling Wei, Qiang Wei, Nong Zhou, Kai Wang, Yanghua Tian","doi":"10.1002/jnr.70056","DOIUrl":"https://doi.org/10.1002/jnr.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune condition associated with neuropsychiatric and cognitive deficits. Changes in the cingulate cortex may be central to this disorder. This study investigates subregional alterations in the cingulate cortex of patients with anti-NMDAR encephalitis and their relationship to cognitive deficits using functional and perfusion imaging. Thirty-eight patients with anti-NMDAR encephalitis and 30 healthy controls (HC) underwent resting-state MRI and neuropsychological assessments. We measured low-frequency amplitude (fALFF), degree centrality (DC), and cerebral blood flow (CBF) in the cingulate cortex, and performed functional connectivity (FC) and CBF connectivity analyses. We also analyzed the relationship between subregional changes and cognitive impairment. Finally, we applied support vector machines (SVM) to classify patients and controls based on functional and perfusion features. Patients with anti-NMDAR encephalitis showed significant cognitive impairments in memory and executive function, along with anxiety symptoms. Neuroimaging revealed decreased fALFF, DC, and CBF in the left pregenual anterior cingulate cortex (pgACC.L). FC between pgACC.L and several brain regions, including the parahippocampal gyrus and precuneus, was reduced. Additionally, pgACC.L exhibited altered CBF connectivity patterns with other brain regions. Moreover, the changes of fALFF, DC, and FC are related to the impaired cognitive function of patients. SVM classification based on fALFF, DC, and CBF features successfully distinguished patients from controls. Our findings suggest that pgACC abnormalities play a key role in the pathomechanism of anti-NMDAR encephalitis and may serve as biomarkers for disease monitoring.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice 白藜芦醇对小鼠颅内动脉瘤破裂的保护作用

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-23 DOI: 10.1002/jnr.70059

Dung Ngoc Phuong Dang, Yoshinobu Kamio, Toru Kawakatsu, Hiroshi Makino, Kazuya Hokamura, Ryo Imai, Yasuhito Suzuki, Hisaya Hiramatsu, Liu Zhitong, Kazuo Umemura, Kazuhiko Kurozumi

{"title":"Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice","authors":"Dung Ngoc Phuong Dang, Yoshinobu Kamio, Toru Kawakatsu, Hiroshi Makino, Kazuya Hokamura, Ryo Imai, Yasuhito Suzuki, Hisaya Hiramatsu, Liu Zhitong, Kazuo Umemura, Kazuhiko Kurozumi","doi":"10.1002/jnr.70059","DOIUrl":"https://doi.org/10.1002/jnr.70059","url":null,"abstract":"<div>\u0000 \u0000 <p>Resveratrol is a polyphenol and potent antioxidant that has anti-inflammatory effects in conditions such as atherosclerosis, aortic aneurysm, and inflammatory bowel disease. In this study, we investigated whether resveratrol exerts anti-inflammatory effects and protects against intracranial aneurysm formation and rupture in male mice. Intracranial aneurysms were induced in mice using a combination of elastase injection into the cerebrospinal fluid and deoxycorticosterone acetate-salt (DOCA-salt)-induced hypertension. Male mice were divided into two groups: a resveratrol diet group and a normal diet group. The dietary intervention lasted for 6 weeks, starting 3 weeks prior to elastase injection. The overall incidence of aneurysms did not differ significantly between the normal diet and resveratrol diet groups (71% vs. 59%, <i>p</i> = 0.497). However, resveratrol significantly reduced the rate of aneurysmal rupture compared with that in the normal diet group (88% vs. 40%, <i>p</i> = 0.026). Furthermore, resveratrol supplementation increased the mRNA levels of Sirtuin 1 (<i>Sirt1</i>) and decreased the mRNA levels of nuclear factor kappa B subunit 1 (<i>Nfkb1</i>) and Tumor necrosis factor (<i>Tnf</i>). Our findings demonstrate that resveratrol reduces intracranial aneurysm rupture in a mouse model, indicating its therapeutic potential in this condition.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Static and Dynamic Functional Connectivity in Tension-Type Headache: A Support Vector Machine Analysis 张力型头痛的异常静态和动态功能连接：支持向量机分析

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-16 DOI: 10.1002/jnr.70057

Mengting Li, Shuxian Zhang, Fan Chu, Yan Zhan, Mengqi Zhao, Zeqi Hao, Linlin Zhan, Jun Ren, Xize Jia

{"title":"Abnormal Static and Dynamic Functional Connectivity in Tension-Type Headache: A Support Vector Machine Analysis","authors":"Mengting Li, Shuxian Zhang, Fan Chu, Yan Zhan, Mengqi Zhao, Zeqi Hao, Linlin Zhan, Jun Ren, Xize Jia","doi":"10.1002/jnr.70057","DOIUrl":"https://doi.org/10.1002/jnr.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>Tension-type headache (TTH) is a primary headache with the highest prevalence. Previous studies have revealed the local brain abnormalities of TTH patients. However, little is known about its brain connectivity disruption. Based on rs-fMRI data from 33 TTH patients and 30 healthy controls (HCs), static functional connectivity (FC) and dynamic FC were calculated between the default mode network (DMN) and the whole brain. Regions of interest (ROIs)-wise FC was performed to explore the connectivity pattern of the circuit established by the static and dynamic FC methods. The support vector machine (SVM) model was applied to distinguish the TTH patients from HCs. Compared with the HCs, TTH patients showed increased FC between the left posterior cingulate cortex (PCC) and the left parahippocampal and left middle frontal gyrus (MFG). Decreased dynamic FC was observed between the left PCC and right middle occipital gyrus (MOG), left precuneus, left inferior parietal gyrus (IPG), right median cingulate and paracingulate gyri (DCG) and right supplementary motor area (SMA) in TTH patients. The ROI-wise FC results showed that left precuneus-left IPG, left precuneus-right DCG, and left IPG-right SMA generated higher FC in TTH patients. SVM obtained a total accuracy of 70.476%, and the area under the curve (AUC) value was 0.658. TTH patients showed abnormal static and dynamic connectivity in multiple brain regions, and abnormal brain activity was also identified within these brain regions. This novel classification model using the brain connectivity could be useful in detecting neuro-markers for clinical applications in TTH patients.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abscisic Acid Enhances Motor and Cognitive Function in the 3-Acetylpyridine Mouse Model of Cerebellar Ataxia 脱落酸增强3-乙酰吡啶小鼠小脑共济失调模型的运动和认知功能

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-16 DOI: 10.1002/jnr.70055

Monavareh Soti, Mehran Ilaghi, Hoda Ranjbar, Kristi A. Kohlmeier, Mansoureh Sabzalizadeh, Mohammad Shabani

{"title":"Abscisic Acid Enhances Motor and Cognitive Function in the 3-Acetylpyridine Mouse Model of Cerebellar Ataxia","authors":"Monavareh Soti, Mehran Ilaghi, Hoda Ranjbar, Kristi A. Kohlmeier, Mansoureh Sabzalizadeh, Mohammad Shabani","doi":"10.1002/jnr.70055","DOIUrl":"https://doi.org/10.1002/jnr.70055","url":null,"abstract":"<div>\u0000 \u0000 <p>Cerebellar ataxia is a debilitating neurodegenerative disorder characterized by impaired motor coordination and balance with limited treatment options. Abscisic acid (ABA), a phytohormone detected in mammalian brains, has shown neuroprotective properties. This study investigated the effects of ABA on motor, cognitive, and affective deficits in a mouse model of cerebellar ataxia in which male Swiss mice received a single intraperitoneal injection of 3-acetylpyridine (3-AP; 60 mg/kg), which leads to the loss of climbing fiber input to Purkinje neurons leading to cerebellar degeneration. In ABA-treated groups, ABA (10 or 15 μg/mouse) was intracerebroventricularly applied for four consecutive days. Behavioral testing consisted of open field, footprint analysis, wire grip, rotarod, tail suspension, elevated plus maze, Morris water maze, and the passive avoidance assay. Cerebellar brain-derived neurotrophic factor (BDNF) levels were measured using ELISA. As expected, 3-AP-treated mice exhibited significant motor impairments, increased anxiety-like and depressive-like behaviors, and cognitive deficits. ABA treatment, particularly at the 15 μg/mouse dose, significantly improved motor coordination, locomotor activity, memory, and spatial and passive avoidance learning as well as reduced anxiety-like and depressive-like behaviors. Behavioral changes were associated with normalization of the 3-AP-induced increases in cerebellar BDNF levels. This study demonstrates that ABA can ameliorate motor, cognitive, and affective deficits in a mouse model of cerebellar ataxia, which could involve BDNF and be due to neuroprotective effects in the cerebellum. By extension, our data suggest that ABA may have therapeutic potential in the management of cerebellar ataxia and other cerebellar disorders.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention Regulation Among Sleep-Deprived Air-Force Pilots 睡眠不足的空军飞行员的注意力调节

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-09 DOI: 10.1002/jnr.70052

Talya Dolev, Inon Maoz, Salman Zubedat, Shlomit Aga-Mizrachi, Anna Levkovsky, Idan Nakdimon, Oded Ben-Ari, Dan Grinstein, Barak Gordon, Avi Avital

{"title":"Attention Regulation Among Sleep-Deprived Air-Force Pilots","authors":"Talya Dolev, Inon Maoz, Salman Zubedat, Shlomit Aga-Mizrachi, Anna Levkovsky, Idan Nakdimon, Oded Ben-Ari, Dan Grinstein, Barak Gordon, Avi Avital","doi":"10.1002/jnr.70052","DOIUrl":"https://doi.org/10.1002/jnr.70052","url":null,"abstract":"<p>Short sleep duration is associated with adverse physical and mental events. However, it is quite challenging to objectively quantify its impact on human cognitive performance. Thus, we aim to examine the effects of sleep deprivation on physiological measures of emotional and attention regulation, in terms of recovery dynamics among sleep-deprived air force pilots. Ninety-one pilots participated in a sleep deprivation workshop held by an aeromedical center. The Auditory Sustained Attention Test (ASAT) and the Psychomotor Vigilance Test were applied to evaluate emotional and attention performance at baseline, post 24-h of sleep deprivation, following recovery of 3- and 8-h of sleep. Machine learning was used to predict the aerial professions based on the physiological measures. The results indicate that 24 h of sleep deprivation induced impairments in both attention and emotional regulation; however, while 3 h of sleep recovery have ameliorated emotional regulation and latency to response inhibition, attention performance required 8 h of sleep to ameliorate the observed 70% impairment. The physiologically measured adverse effects induced by sleep deprivation were distinctive among aerial professions, thus allowing machine learning prediction with high accuracy, sensitivity, and specificity. The effects of sleep-deprivation-induced fatigue were detected by the ASAT measures, which may be utilized as an objective, non-invasive physiological measure to quantify emotional and attention regulation. The ability to monitor sleep effects in a fast and accurate manner may be beneficial for the competence assessment of pilots and promote safety, and the differentiation across the aerial professions may potentially improve individual suitability assessment, together with the consequences of sleep deprivation.</p>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID COVID急性后后遗症晚期执行功能下降及其与TNF-α的关系

IF 2.9 3区医学

Journal of Neuroscience Research Pub Date : 2025-06-08 DOI: 10.1002/jnr.70051

Aditi Varenya, K. Vijayalakshmi, Mythri Rajeswara Babu

{"title":"Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID","authors":"Aditi Varenya, K. Vijayalakshmi, Mythri Rajeswara Babu","doi":"10.1002/jnr.70051","DOIUrl":"https://doi.org/10.1002/jnr.70051","url":null,"abstract":"<div>\u0000 \u0000 <p>Beyond the immediate impact of the COVID-19 pandemic, survivors often grapple with incapacitating post-infection symptoms, referred to as Post-Acute Sequelae of COVID (PASC) when persistent beyond 90 days. Cognitive manifestations, encompassing attention, memory, and executive functions (EF), collectively termed brain fog, contribute to functional challenges in PASC. This infection also elicits a long-lasting pro-inflammatory response that persists even after viral clearance, potentially correlated with brain fog. However, it is unclear whether pro-inflammatory responses and cognitive sequelae persist beyond 1 year after the onset of infection. Thus, this study sought to investigate the long-term consequences of PASC on EFs as well as a potential association with markers of inflammation. Forty individuals with PASC who passed performance validity testing (PVT) and 40 matched healthy controls (HC) underwent neuropsychological assessments, including the Montreal Cognitive Assessment to assess global cognition, Victoria Stroop Test to assess inhibitory control, Wisconsin Card Sorting Test to assess cognitive flexibility, Digit Span Task to assess working memory, and Mackworth Clock Test to assess sustained attention on the Psychology Experiment Building Language (PEBL) toolkit. Serum was assayed for tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10). Results indicate significant EF decline in PASC, inversely correlated with serum TNF-α concentrations, approximately 562 ± 225 days after the onset of infection. Thus, there exists protracted EF decline in PASC, persistent even beyond 1 year after the onset of infection. Increased levels of TNF-α are observed to be associated with poorer executive functioning in PASC.</p>\u0000 </div>","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"103 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0