莫亚莫亚病晚期的淋巴系统损伤

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Lingji Jin, Junwen Hu, Guangxu Han, Yin Li, Jun Zhu, Yuhan Zhu, Xuchao He, Duo Xu, Leilei Zheng, Ruiliang Bai, Lin Wang
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引用次数: 0

摘要

利用弥散张量成像分析和血管周围空间(DTI-ALPS)评估甘油系统的活动可能有助于了解莫亚莫亚病(MMD)的病理生理学。研究人员对 63 名成年 MMD 患者和 20 名健康对照组(HCs)进行了 T1 加权成像、T2-FLAIR、假连续动脉自旋标记和 DTI 分析。60名患者在联合血管重建术后6个月以上进行了数字减影血管造影。对MMD患者的铃木分期、术后松岛分级、脑室周围吻合(PA)、血管周围间隙增大(EPVS)、皮层深部和皮层下白质增厚(DSWMH)、DTI-ALPS、脑血流(CBF)和认知量表进行了评估。根据铃木分期将 MMD 患者分为早期和晚期。我们发现晚期患者的DTI-ALPS相对于HC(P = 0.046)和早期患者(P = 0.004)较低,出血性MMD相对于缺血性MMD(P = 0.048)较低,PA 2级相对于0级(P = 0.010)较低。DTI-ALPS 与基底节 EPVS(r = -0.686,p <0.001)、铃木分期(r = -0.465,p <0.001)、DSWMH(r = -0.423,p =0.001)、整体 CBF(r = 0.300,p = 0.017)和认知评分(r = 0.343,p = 0.018)相关。术后侧支形成良好的患者的 DTI-ALPS 高于术后侧支形成不良的患者(p = 0.038)。总之,晚期多发性硬化症患者的淋巴系统受损,可能会影响认知功能和术后新血管生成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Glymphatic System Impairment in the Advanced Stage of Moyamoya Disease

Glymphatic System Impairment in the Advanced Stage of Moyamoya Disease

Assessing the glymphatic system activity using diffusion tensor imaging analysis along with the perivascular space (DTI-ALPS) may be helpful to understand the pathophysiology of moyamoya disease (MMD). 63 adult patients with MMD and 20 healthy controls (HCs) were included for T1-weighted images, T2-FLAIR, pseudocontinuous arterial spin labeling, and DTI. 60 patients had digital subtraction angiography more than 6 months after combined revascularization. The Suzuki stage, postoperative Matsushima grade, periventricular anastomoses (PA), enlarged perivascular spaces (EPVS), deep and subcortical white matter hyperintensities (DSWMH), DTI-ALPS, cerebral blood flow (CBF), and cognitive scales of MMD patients were assessed. MMD patients were divided into early and advanced stage based on the Suzuki stage. We detected lower DTI-ALPS in patients with advanced stage relative to HCs (p = 0.046) and patients with early stage (p = 0.004), hemorrhagic MMD compared with ischemic MMD (p = 0.048), and PA Grade 2 compared with Grade 0 (p = 0.010). DTI-ALPS was correlated with the EPVS in basal ganglia (r = −0.686, p < 0.001), Suzuki stage (r = −0.465, p < 0.001), DSWMH (r = −0.423, p = 0.001), and global CBF (r = 0.300, p = 0.017) and cognitive scores (r = 0.343, p = 0.018). The DTI-ALPS of patients with good postoperative collateral formation was higher compared to those with poor postoperative collateral formation (p = 0.038). In conclusion, the glymphatic system was impaired in advanced MMD patients and may affected cognitive function and postoperative neoangiogenesis.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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