Journal of Neuroscience Research最新文献_第9页

The gut microbiome modulates the susceptibility to traumatic stress in a sex-dependent manner 肠道微生物组以性别依赖的方式调节创伤应激的易感性。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-03-04 DOI: 10.1002/jnr.25315

Dan Shen, Liang Chang, Feng Su, Shihao Huang, Hubo Xu, Yue Si, Feng Wang, Yanxue Xue

{"title":"The gut microbiome modulates the susceptibility to traumatic stress in a sex-dependent manner","authors":"Dan Shen, Liang Chang, Feng Su, Shihao Huang, Hubo Xu, Yue Si, Feng Wang, Yanxue Xue","doi":"10.1002/jnr.25315","DOIUrl":"10.1002/jnr.25315","url":null,"abstract":"Post-traumatic stress disorder (PTSD), a psychological condition triggered by exposure to extreme or chronic stressful events, exhibits a sex bias in incidence and clinical manifestations. Emerging research implicates the gut microbiome in the pathogenesis of PTSD and its roles in stress susceptibility. However, it is unclear whether differential gut microbiota contribute to PTSD susceptibility in male and female rats. Here, we utilized the single prolonged stress animal model and employed unsupervised machine learning to classify stressed animals into stress-susceptible subgroups and stress-resilient subgroups. Subsequently, using 16S V3-V4 rDNA sequencing, we investigated the differential gut microbiota alterations between susceptible and resilient individuals in male and female rats. Our findings revealed distinct changes in gut microbiota composition between the sexes at different taxonomic levels. Furthermore, the abundance of Parabacteroides was lower in rats that underwent SPS modeling compared to the control group. In addition, the abundance of Tenericutes in the stress-susceptible subgroup was higher than that in the control group and stress-resilient subgroup, suggesting that Tenericutes may be able to characterize stress susceptibility. What is particularly interesting here is that Cyanobacteria may be particularly associated with anti-anxiety effects in male rats. This study underscores sex-specific variations in gut microbiota composition in response to stress and sex differences should be taken into account when using macrobiotics for neuropsychiatric treatment, highlighting potential targets for PTSD therapeutic interventions.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep-stage-dependent alterations in cerebral oxygen metabolism quantified by magnetic resonance 通过磁共振量化大脑氧代谢随睡眠阶段而发生的变化。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-28 DOI: 10.1002/jnr.25313

Jing Xu, Andrew Wiemken, Michael C. Langham, Hengyi Rao, Marianne Nabbout, Alessandra S. Caporale, Richard J. Schwab, John A. Detre, Felix W. Wehrli

{"title":"Sleep-stage-dependent alterations in cerebral oxygen metabolism quantified by magnetic resonance","authors":"Jing Xu, Andrew Wiemken, Michael C. Langham, Hengyi Rao, Marianne Nabbout, Alessandra S. Caporale, Richard J. Schwab, John A. Detre, Felix W. Wehrli","doi":"10.1002/jnr.25313","DOIUrl":"10.1002/jnr.25313","url":null,"abstract":"A key function of sleep is to provide a regular period of reduced brain metabolism, which is critical for maintenance of healthy brain function. The purpose of this work was to quantify the sleep-stage-dependent changes in brain energetics in terms of cerebral metabolic rate of oxygen (CMRO2) as a function of sleep stage using quantitative magnetic resonance imaging (MRI) with concurrent electroencephalography (EEG) during sleep in the scanner. Twenty-two young and older subjects with regular sleep hygiene and Pittsburgh Sleep Quality Index (PSQI) in the normal range were recruited for the study. Cerebral blood flow (CBF) and venous oxygen saturation (SvO2) were obtained simultaneously at 3 Tesla field strength and 2.7-s temporal resolution during an 80-min time series using OxFlow, an in-house developed imaging sequence. The method yields whole-brain CMRO2 in absolute physiologic units via Fick's Principle. Nineteen subjects yielded evaluable data free of subject motion artifacts. Among these subjects, 10 achieved slow-wave (N3) sleep, 16 achieved N2 sleep, and 19 achieved N1 sleep while undergoing the MRI protocol during scanning. Mean CMRO2 was 98 ± 7(μmol min−1)/100 g awake, declining progressively toward deepest sleep stage: 94 ± 10.8 (N1), 91 ± 11.4 (N2), and 76 ± 9.0 μmol min−1/100 g (N3), with each level differing significantly from the wake state. The technology described is able to quantify cerebral oxygen metabolism in absolute physiologic units along with non-REM sleep stage, indicating brain oxygen consumption to be closely associated with depth of sleep, with deeper sleep stages exhibiting progressively lower CMRO2 levels.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cone cell dysfunction attenuates retinal neovascularization in oxygen-induced retinopathy mouse model 锥状细胞功能障碍可减轻氧诱导视网膜病变小鼠模型中视网膜新生血管的形成。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-28 DOI: 10.1002/jnr.25316

Jun Wu, Dong Hyun Jo, Marcus Fruttiger, Jeong Hun Kim

{"title":"Cone cell dysfunction attenuates retinal neovascularization in oxygen-induced retinopathy mouse model","authors":"Jun Wu, Dong Hyun Jo, Marcus Fruttiger, Jeong Hun Kim","doi":"10.1002/jnr.25316","DOIUrl":"10.1002/jnr.25316","url":null,"abstract":"Aberrant neovascularization is the most common feature in retinopathy of prematurity (ROP), which leads to the retinal detachment and visual defects in neonates with a low gestational age eventually. Understanding the regulation of inappropriate angiogenic signaling benefits individuals at-risk. Recently, neural activity originating from the specific neural activity has been considered to contribute to retinal angiogenesis. Here, we explored the impact of cone cell dysfunction on oxygen-induced retinopathy (OIR), a mouse model commonly employed to understand retinal diseases associated with abnormal blood vessel growth, using the Gnat2cpfl3 (cone photoreceptor function loss-3) strain of mice (regardless of the sex), which is known for its inherent cone cell dysfunction. We found that the retinal avascular area, hypoxic area, and neovascular area were significantly attenuated in Gnat2cpfl3 OIR mice compared to those in C57BL/6 OIR mice. Moreover, the HIF-1α/VEGF axis was also reduced in Gnat2cpfl3 OIR mice. Collectively, our results indicated that cone cell dysfunction, as observed in Gnat2cpfl3 OIR mice, leads to attenuated retinal neovascularization. This finding suggests that retinal neural activity may precede and potentially influence the onset of pathological neovascularization.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship 突触可塑性与线粒体自噬关系研究的进展。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-23 DOI: 10.1002/jnr.25309

Yousong Zhu, Qinlong Hui, Zheng Zhang, Hao Fu, Yali Qin, Qiong Zhao, Qinqing Li, Junlong Zhang, Lei Guo, Wenbin He, Cheng Han

{"title":"Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship","authors":"Yousong Zhu, Qinlong Hui, Zheng Zhang, Hao Fu, Yali Qin, Qiong Zhao, Qinqing Li, Junlong Zhang, Lei Guo, Wenbin He, Cheng Han","doi":"10.1002/jnr.25309","DOIUrl":"10.1002/jnr.25309","url":null,"abstract":"Synapses serve as the points of communication between neurons, consisting primarily of three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane. They transmit signals through the release and reception of neurotransmitters. Synaptic plasticity, the ability of synapses to undergo structural and functional changes, is influenced by proteins such as growth-associated proteins, synaptic vesicle proteins, postsynaptic density proteins, and neurotrophic growth factors. Furthermore, maintaining synaptic plasticity consumes more than half of the brain's energy, with a significant portion of this energy originating from ATP generated through mitochondrial energy metabolism. Consequently, the quantity, distribution, transport, and function of mitochondria impact the stability of brain energy metabolism, thereby participating in the regulation of fundamental processes in synaptic plasticity, including neuronal differentiation, neurite outgrowth, synapse formation, and neurotransmitter release. This article provides a comprehensive overview of the proteins associated with presynaptic plasticity, postsynaptic plasticity, and common factors between the two, as well as the relationship between mitochondrial energy metabolism and synaptic plasticity.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding functional brain reorganization for naturalistic piano playing in novice pianists 了解钢琴新手自然钢琴演奏的大脑功能重组。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-23 DOI: 10.1002/jnr.25312

Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Agnieszka Widlarz, Aleksandra M. Herman, Artur Marchewka

{"title":"Understanding functional brain reorganization for naturalistic piano playing in novice pianists","authors":"Alicja M. Olszewska, Maciej Gaca, Dawid Droździel, Agnieszka Widlarz, Aleksandra M. Herman, Artur Marchewka","doi":"10.1002/jnr.25312","DOIUrl":"10.1002/jnr.25312","url":null,"abstract":"Learning to play the piano is a unique complex task, integrating multiple sensory modalities and higher order cognitive functions. Longitudinal neuroimaging studies on adult novice musicians show training-related functional changes in music perception tasks. The reorganization of brain activity while actually playing an instrument was studied only on a very short time frame of a single fMRI session, and longer interventions have not yet been performed. Thus, our aim was to investigate the dynamic complexity of functional brain reorganization while playing the piano within the first half year of musical training. We scanned 24 novice keyboard learners (female, 18–23 years old) using fMRI while they played increasingly complex musical pieces after 1, 6, 13, and 26 weeks of training. Playing music evoked responses bilaterally in the auditory, inferior frontal, and supplementary motor areas, and the left sensorimotor cortex. The effect of training over time, however, invoked widespread changes encompassing the right sensorimotor cortex, cerebellum, superior parietal cortex, anterior insula and hippocampus, among others. As the training progressed, the activation of these regions decreased while playing music. Post hoc analysis revealed region-specific time-courses for independent auditory and motor regions of interest. These results suggest that while the primary sensory, motor, and frontal regions are associated with playing music, the training decreases the involvement of higher order cognitive control and integrative regions, and basal ganglia. Moreover, training might affect distinct brain regions in different ways, providing evidence in favor of the dynamic nature of brain plasticity.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does transcranial direct current stimulation of the primary motor cortex improve implicit motor sequence learning in Parkinson's disease? 经颅直流电刺激初级运动皮层能否改善帕金森病患者的内隐运动序列学习？

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-23 DOI: 10.1002/jnr.25311

Mahyar Firouzi, Kris Baetens, Eva Swinnen, Chris Baeken, Frank Van Overwalle, Natacha Deroost

{"title":"Does transcranial direct current stimulation of the primary motor cortex improve implicit motor sequence learning in Parkinson's disease?","authors":"Mahyar Firouzi, Kris Baetens, Eva Swinnen, Chris Baeken, Frank Van Overwalle, Natacha Deroost","doi":"10.1002/jnr.25311","DOIUrl":"10.1002/jnr.25311","url":null,"abstract":"Implicit motor sequence learning (IMSL) is a cognitive function that is known to be associated with impaired motor function in Parkinson's disease (PD). We previously reported positive effects of transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) on IMSL in 11 individuals with PD with mild cognitive impairments (MCI), with the largest effects occurring during reacquisition. In the present study, we included 35 individuals with PD, with (n = 15) and without MCI (n = 20), and 35 age- and sex-matched controls without PD, with (n = 13) and without MCI (n = 22). We used mixed-effects models to analyze anodal M1 tDCS effects on acquisition (during tDCS), short-term (five minutes post-tDCS) and long-term reacquisition (one-week post-tDCS) of general and sequence-specific learning skills, as measured by the serial reaction time task. At long-term reacquisition, anodal tDCS resulted in smaller general learning effects compared to sham, only in the PD group, p = .018, possibly due to floor effects. Anodal tDCS facilitated the acquisition of sequence-specific learning (M = 54.26 ms) compared to sham (M = 38.98 ms), p = .003, regardless of group (PD/controls). Further analyses revealed that this positive effect was the largest in the PD-MCI group (anodal: M = 69.07 ms; sham: M = 24.33 ms), p < .001. Although the observed effect did not exceed the stimulation period, this single-session tDCS study confirms the potential of tDCS to enhance IMSL, with the largest effects observed in patients with lower cognitive status. These findings add to the body of evidence that anodal tDCS can beneficially modulate the abnormal basal ganglia network activity that occurs in PD.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task-induced changes in brain entropy 任务诱发的大脑熵变化

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-23 DOI: 10.1002/jnr.25310

Aldo Camargo, Gianpaolo Del Mauro, Ze Wang

{"title":"Task-induced changes in brain entropy","authors":"Aldo Camargo, Gianpaolo Del Mauro, Ze Wang","doi":"10.1002/jnr.25310","DOIUrl":"10.1002/jnr.25310","url":null,"abstract":"Entropy indicates irregularity of a dynamic system, with higher entropy indicating higher irregularity and more transit states. In the human brain, regional brain entropy (BEN) has been increasingly assessed using resting state fMRI (rs-fMRI), while changes of regional BEN during task-based fMRI have been scarcely studied. The purpose of this study is to characterize task-induced regional BEN alterations using the large Human Connectome Project (HCP) data. To control the potential modulation by the block design, BEN of task-fMRI was calculated from the fMRI images acquired during the task conditions only (task BEN) and then compared to BEN of rs-fMRI (resting BEN). Moreover, BEN was separately calculated from the control blocks of the task-fMRI runs (control BEN) and compared to task BEN. Finally, control BEN was compared to resting BEN to test for residual task effects in the control condition. With respect to resting state, task performance unanimously induced BEN reduction in the peripheral cortical area and BEN increase in the centric part of the sensorimotor and perception networks. Control compared to resting BEN showed similar entropy alterations, suggesting large residual task effects. Task compared to control BEN was characterized by reduced entropy in occipital, orbitofrontal, and parietal regions.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover 封面

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-21 DOI: 10.1002/jnr.25314

引用次数: 0

A volumetric asymmetry study of gray matter in individuals with and without dyslexia 阅读障碍患者和非阅读障碍患者灰质体积不对称研究。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-15 DOI: 10.1002/jnr.25305

Kelly Nisbet, Avary Kostiw, Thi Kim Truc Huynh, Sukhmani Kaur Saggu, Dev Patel, Jacqueline Cummine

{"title":"A volumetric asymmetry study of gray matter in individuals with and without dyslexia","authors":"Kelly Nisbet, Avary Kostiw, Thi Kim Truc Huynh, Sukhmani Kaur Saggu, Dev Patel, Jacqueline Cummine","doi":"10.1002/jnr.25305","DOIUrl":"10.1002/jnr.25305","url":null,"abstract":"Brain imaging work aimed at increased classification of dyslexia has underscored an important relationship between anterior (i.e., the inferior frontal gyrus; IFG) and posterior (i.e., superior temporal gyrus and supramarginal gyrus) brain regions. The extent to which the three components of the inferior frontal gyrus, namely the pars orbitalis, triangularis, and opercularis, are differentially related to the posterior regions, namely the superior temporal gyrus and supramarginal gyrus, needs further elucidation. Information about the nature of the anterior–posterior connections would facilitate our understanding of the neural underpinnings associated with dyslexia. Adult participants (N = 38; 16 with dyslexia) took part in an MRI study, whereby high-resolution structural scans were obtained. Volumetric asymmetry of the three regions of the IFG, the superior temporal gyrus, and the supramarginal gyrus was extracted. Significant differences were found for each of the three IFG regions, such that skilled readers had a greater leftward asymmetry of the orbitalis and triangularis, and greater rightward asymmetry of the opercularis, when compared to individuals with dyslexia. Furthermore, the pars triangularis was significantly associated with leftward asymmetry of the superior temporal gyrus for skilled but not dyslexic participants. For individuals with dyslexia, the cortical asymmetry of the IFG, and the corresponding connections with other reading-related brain regions, is inherently different from skilled readers. We discuss our findings in the context of the print-to-speech framework to further our understanding of the neural underpinnings associated with dyslexia.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fronto-limbic white matter microstructural changes in psychiatrically healthy adults with childhood trauma 有童年创伤的精神健康成年人的前边缘白质微结构变化。

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-02-15 DOI: 10.1002/jnr.25308

Chanellé Hendrikse, Hilmar Klaus Lückhoff, Jean-Paul Fouché, Leigh L. van den Heuvel, Robin Emsley, Soraya Seedat, Stefan du Plessis

{"title":"Fronto-limbic white matter microstructural changes in psychiatrically healthy adults with childhood trauma","authors":"Chanellé Hendrikse, Hilmar Klaus Lückhoff, Jean-Paul Fouché, Leigh L. van den Heuvel, Robin Emsley, Soraya Seedat, Stefan du Plessis","doi":"10.1002/jnr.25308","DOIUrl":"10.1002/jnr.25308","url":null,"abstract":"Childhood trauma (CT) may influence brain white matter microstructure; however, few studies have examined the differential impact of distinct CT types on white matter microstructure in psychiatrically healthy adults living in a developing country. In adults without significant medical or psychiatric disorders, we investigated the association(s) between CT, including abuse and neglect, and fractional anisotropy (FA) of limbic tracts previously shown to be associated with CT. Participants underwent diffusion tensor imaging and completed the Childhood Trauma Questionnaire. Multivariate analysis of variance models were used to test the effects of total overall CT, as well as CT subtypes, on FA in six fronto-limbic tracts, adjusting for age, sex, and educational level. The final sample included 69 adults (age 47 ± 17 years; 70% female). Overall, CT had a significant main effect on FA for tracts of interest (p < .001). Greater CT severity was associated with lower FA for the bilateral and left stria terminalis (uncorrected) as well as the bilateral, left, and right anterior limb of the internal capsule (ALIC; corrected). Exposure to total non-violent/deprivational trauma specifically was associated with lower FA of the bilateral, left, and right ALIC, suggesting that distinct types of CT are associated with differential white matter changes in apparently healthy adults. The ALIC predominantly carries fibers connecting the thalamus with prefrontal cortical regions. Microstructural alterations in the ALIC may be associated with functional brain changes, which may be adaptive or increase the risk of accelerated age-related cognitive decline, maladaptive behaviors, and subsyndromal psychiatric symptoms.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0