Journal of Neuroscience Research最新文献_第9页

4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice 4R-cembranoid 可抑制神经胶质细胞的炎症表型，防止经 LPS 处理的小鼠海马神经元丧失

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-24 DOI: 10.1002/jnr.25336

Luis A. Rojas-Colón, John B. Redell, Pramod K. Dash, Pedro E. Vegas, Wanda Vélez-Torres

{"title":"4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice","authors":"Luis A. Rojas-Colón, John B. Redell, Pramod K. Dash, Pedro E. Vegas, Wanda Vélez-Torres","doi":"10.1002/jnr.25336","DOIUrl":"https://doi.org/10.1002/jnr.25336","url":null,"abstract":"Chronic neuroinflammation has been implicated in neurodegenerative disease pathogenesis. A key feature of neuroinflammation is neuronal loss and glial activation, including microglia and astrocytes. 4R-cembranoid (4R) is a natural compound that inhibits hippocampal pro-inflammatory cytokines and increases memory function in mice. We used the lipopolysaccharide (LPS) injection model to study the effect of 4R on neuronal density and microglia and astrocyte activation. C57BL/6J wild-type mice were injected with LPS (5 mg/kg) and 2 h later received either 4R (6 mg/kg) or vehicle. Mice were sacrificed after 72 h for analysis of brain pathology. Confocal images of brain sections immunostained for microglial, astrocyte, and neuronal markers were used to quantify cellular hippocampal phenotypes and neurons. Hippocampal lysates were used to measure the expression levels of neuronal nuclear protein (NeuN), inducible nitrous oxide synthase (iNOS), arginase-1, thrombospondin-1 (THBS1), glial cell-derived neurotrophic factor (GDNF), and orosomucoid-2 (ORM2) by western blot. iNOS and arginase-1 are widely used protein markers of pro- and anti-inflammatory microglia, respectively. GDNF promotes neuronal survival, and ORM2 and THBS1 are astrocytic proteins that regulate synaptic plasticity and inhibit microglial activation. 4R administration significantly reduced neuronal loss and the number of pro-inflammatory microglia 72 h after LPS injection. It also decreased the expression of the pro-inflammatory protein iNOS while increasing arginase-1 expression, supporting its anti-inflammatory role. The protein expression of THBS1, GDNF, and ORM2 was increased by 4R. Our data show that 4R preserves the integrity of hippocampal neurons against LPS-induced neuroinflammation in mice.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mismatch novelty exploration training shifts VPAC1 receptor-mediated modulation of hippocampal synaptic plasticity by endogenous VIP in male rats 错配新奇探索训练改变了雄性大鼠 VPAC1 受体介导的内源性 VIP 对海马突触可塑性的调节作用

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-24 DOI: 10.1002/jnr.25333

Fatima Aidil-Carvalho, Ana Caulino-Rocha, Joaquim Alexandre Ribeiro, Diana Cunha-Reis

{"title":"Mismatch novelty exploration training shifts VPAC1 receptor-mediated modulation of hippocampal synaptic plasticity by endogenous VIP in male rats","authors":"Fatima Aidil-Carvalho, Ana Caulino-Rocha, Joaquim Alexandre Ribeiro, Diana Cunha-Reis","doi":"10.1002/jnr.25333","DOIUrl":"https://doi.org/10.1002/jnr.25333","url":null,"abstract":"Novelty influences hippocampal-dependent memory through metaplasticity. Mismatch novelty detection activates the human hippocampal CA1 area and enhances rat hippocampal-dependent learning and exploration. Remarkably, mismatch novelty training (NT) also enhances rodent hippocampal synaptic plasticity while inhibition of VIP interneurons promotes rodent exploration. Since VIP, acting on VPAC1 receptors (Rs), restrains hippocampal LTP and depotentiation by modulating disinhibition, we now investigated the impact of NT on VPAC1 modulation of hippocampal synaptic plasticity in male Wistar rats. NT enhanced both CA1 hippocampal LTP and depotentiation unlike exploring an empty holeboard (HT) or a fixed configuration of objects (FT). Blocking VIP VPAC1Rs with PG 97269 (100 nM) enhanced both LTP and depotentiation in naïve animals, but this effect was less effective in NT rats. Altered endogenous VIP modulation of LTP was absent in animals exposed to the empty environment (HT). HT and FT animals showed mildly enhanced synaptic VPAC1R levels, but neither VIP nor VPAC1R levels were altered in NT animals. Conversely, NT enhanced the GluA1/GluA2 AMPAR ratio and gephyrin synaptic content but not PSD-95 excitatory synaptic marker. In conclusion, NT influences hippocampal synaptic plasticity by reshaping brain circuits modulating disinhibition and its control by VIP-expressing hippocampal interneurons while upregulation of VIP VPAC1Rs is associated with the maintenance of VIP control of LTP in FT and HT animals. This suggests VIP receptor ligands may be relevant to co-adjuvate cognitive recovery therapies in aging or epilepsy, where LTP/LTD imbalance occurs.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation 星形胶质细胞缺铁会改变细胞状态并影响少突胶质细胞的分化

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-24 DOI: 10.1002/jnr.25334

María Silvina Marcora, Vanesa Soledad Mattera, Pilar Goñi, Florencia Aybar, Jorge Daniel Correale, Juana Maria Pasquini

{"title":"Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation","authors":"María Silvina Marcora, Vanesa Soledad Mattera, Pilar Goñi, Florencia Aybar, Jorge Daniel Correale, Juana Maria Pasquini","doi":"10.1002/jnr.25334","DOIUrl":"https://doi.org/10.1002/jnr.25334","url":null,"abstract":"Iron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and astrocyte (AST) maturation was impaired. To explore the contribution of AST iron to the myelination process, we generated an in vitro ID model by silencing divalent metal transporter 1 (DMT1) in AST (siDMT1 AST) or treating AST with Fe3+ chelator deferoxamine (DFX; DFX AST). siDMT1 AST showed no changes in proliferation but remained immature. Co-cultures of oligodendrocyte precursors cells (OPC) with siDMT1 AST and OPC cultures incubated with siDMT1 AST-conditioned media (ACM) rendered a reduction in OPC maturation. These findings correlated with a decrease in the expression of AST-secreted factors IGF-1, NRG-1, and LIF, known to promote OPC differentiation. siDMT1 AST also displayed increased mitochondrial number and reduced mitochondrial size as compared to control cells. DFX AST also remained immature and DFX AST-conditioned media also hampered OPC maturation in culture, in keeping with a decrease in the expression of AST-secreted growth factors IGF-1, NRG-1, LIF, and CNTF. DFX AST mitochondrial morphology and number showed results similar to those observed in siDMT1 AST. In sum, our results show that ID, induced through two different methods, impacts AST maturation and mitochondrial functioning, which in turn hampers OPC differentiation.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice 老龄小鼠视网膜下丘脑束和丘脑上核之间的谷氨酸能神经传递增加

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-23 DOI: 10.1002/jnr.25331

J. Manuel Herrera-Zamora, Fernando Osuna-Lopez, Miriam E. Reyes-Méndez, Ramon E. Valadez-Lemus, Enrique A. Sánchez-Pastor, Ricardo A. Navarro-Polanco, Eloy G. Moreno-Galindo, Javier Alamilla

{"title":"Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice","authors":"J. Manuel Herrera-Zamora, Fernando Osuna-Lopez, Miriam E. Reyes-Méndez, Ramon E. Valadez-Lemus, Enrique A. Sánchez-Pastor, Ricardo A. Navarro-Polanco, Eloy G. Moreno-Galindo, Javier Alamilla","doi":"10.1002/jnr.25331","DOIUrl":"https://doi.org/10.1002/jnr.25331","url":null,"abstract":"Circadian rhythms synchronize to light through the retinohypothalamic tract (RHT), which is a bundle of axons coming from melanopsin retinal ganglion cells, whose synaptic terminals release glutamate to the ventral suprachiasmatic nucleus (SCN). Activation of AMPA–kainate and NMDA postsynaptic receptors elicits the increase in intracellular calcium required for triggering the signaling cascade that ends in phase shifts. During aging, there is a decline in the synchronization of circadian rhythms to light. With electrophysiological (whole-cell patch-clamp) and immunohistochemical assays, in this work, we studied pre- and postsynaptic properties between the RHT and ventral SCN neurons in young adult (P90–120) and old (P540–650) C57BL/6J mice. Incremental stimulation intensities (applied on the optic chiasm) induced much lesser AMPA–kainate postsynaptic responses in old animals, implying a lower recruitment of RHT fibers. Conversely, a higher proportion of old SCN neurons exhibited synaptic facilitation, and variance–mean analysis indicated an increase in the probability of release in RHT terminals. Moreover, both spontaneous and miniature postsynaptic events displayed larger amplitudes in neurons from aged mice, whereas analysis of the NMDA and AMPA–kainate components (evoked by RHT electrical stimulation) disclosed no difference between the two ages studied. Immunohistochemistry revealed a bigger size in the puncta of vGluT2, GluN2B, and GluN2A of elderly animals, and the number of immunopositive particles was increased, but that of PSD-95 was reduced. All these synaptic adaptations could be part of compensatory mechanisms in the glutamatergic signaling to ameliorate the loss of RHT terminals in old animals.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical-basal ganglia subcircuit 帕金森氏症源于离散的次级运动皮质，肌张力障碍源于初级运动皮质-基底节亚回路

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-23 DOI: 10.1002/jnr.25328

Deepak Kumbhare, George Weistroffer, Sofia Goyanaga, Zi Ling Huang, Jacob Blagg, Mark S. Baron

{"title":"Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical-basal ganglia subcircuit","authors":"Deepak Kumbhare, George Weistroffer, Sofia Goyanaga, Zi Ling Huang, Jacob Blagg, Mark S. Baron","doi":"10.1002/jnr.25328","DOIUrl":"https://doi.org/10.1002/jnr.25328","url":null,"abstract":"Although manifesting contrasting phenotypes, Parkinson's disease and dystonia, the two most common movement disorders, can originate from similar pathophysiology. Previously, we demonstrated that lesioning (silencing) of a discrete dorsal region in the globus pallidus (rodent equivalent to globus pallidus externa) in rats and produced parkinsonism, while lesioning a nearby ventral hotspot-induced dystonia. Presently, we injected fluorescent-tagged multi-synaptic tracers into these pallidal hotspots (n = 36 Long Evans rats) and permitted 4 days for the viruses to travel along restricted connecting pathways and reach the motor cortex before sacrificing the animals. Viral injections in the Parkinson's hotspot fluorescent labeled a circumscribed region in the secondary motor cortex, while injections in the dystonia hotspot labeled within the primary motor cortex. Custom probability mapping and N200 staining affirmed the segregation of the cortical territories for Parkinsonism and dystonia to the secondary and primary motor cortices. Intracortical microstimulation localized territories specifically to their respective rostral and caudal microexcitable zones. Parkinsonian features are thus explained by pathological signaling within a secondary motor subcircuit normally responsible for initiation and scaling of movement, while dystonia is explained by abnormal (and excessive) basal ganglia signaling directed at primary motor corticospinal transmission.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal mechanisms regulating locomotion in adult Drosophila 调节成年果蝇运动的神经元机制

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-22 DOI: 10.1002/jnr.25332

Swetha B. M. Gowda, Ayesha Banu, Sadam Hussain, Farhan Mohammad

{"title":"Neuronal mechanisms regulating locomotion in adult Drosophila","authors":"Swetha B. M. Gowda, Ayesha Banu, Sadam Hussain, Farhan Mohammad","doi":"10.1002/jnr.25332","DOIUrl":"https://doi.org/10.1002/jnr.25332","url":null,"abstract":"The coordinated action of multiple leg joints and muscles is required even for the simplest movements. Understanding the neuronal circuits and mechanisms that generate precise movements is essential for comprehending the neuronal basis of the locomotion and to infer the neuronal mechanisms underlying several locomotor-related diseases. Drosophila melanogaster provides an excellent model system for investigating the neuronal circuits underlying motor behaviors due to its simple nervous system and genetic accessibility. This review discusses current genetic methods for studying locomotor circuits and their function in adult Drosophila. We highlight recently identified neuronal pathways that modulate distinct forward and backward locomotion and describe the underlying neuronal control of leg swing and stance phases in freely moving flies. We also report various automated leg tracking methods to measure leg motion parameters and define inter-leg coordination, gait and locomotor speed of freely moving adult flies. Finally, we emphasize the role of leg proprioceptive signals to central motor circuits in leg coordination. Together, this review highlights the utility of adult Drosophila as a model to uncover underlying motor circuitry and the functional organization of the leg motor system that governs correct movement.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to Increased hippocampal cannabinoid 1 receptor expression is associated with protection from severe seizures in pregnant mice with reduced uterine perfusion pressure 更正：海马大麻素 1 受体表达的增加与子宫灌注压降低的妊娠小鼠免受严重癫痫发作的影响有关

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-17 DOI: 10.1002/jnr.25326

引用次数: 0

What do brain oscillations tell about the human sense of smell? 大脑振荡对人类嗅觉有何启示？

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-17 DOI: 10.1002/jnr.25335

Coralie Mignot, Susanne Weise, Dino Podlesek, Georg Leonhardt, Moustafa Bensafi, Thomas Hummel

引用次数: 0

Morphological heterogeneity of neurons in the human central amygdaloid nucleus 人类杏仁核中央神经元的形态异质性

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-17 DOI: 10.1002/jnr.25319

Carlos E. Vásquez, Kétlyn T. Knak Guerra, Josué Renner, Alberto A. Rasia-Filho

{"title":"Morphological heterogeneity of neurons in the human central amygdaloid nucleus","authors":"Carlos E. Vásquez, Kétlyn T. Knak Guerra, Josué Renner, Alberto A. Rasia-Filho","doi":"10.1002/jnr.25319","DOIUrl":"https://doi.org/10.1002/jnr.25319","url":null,"abstract":"The central amygdaloid nucleus (CeA) has an ancient phylogenetic development and functions relevant for animal survival. Local cells receive intrinsic amygdaloidal information that codes emotional stimuli of fear, integrate them, and send cortical and subcortical output projections that prompt rapid visceral and social behavior responses. We aimed to describe the morphology of the neurons that compose the human CeA (N = 8 adult men). Cells within CeA coronal borders were identified using the thionine staining and were further analyzed using the “single-section” Golgi method followed by open-source software procedures for two-dimensional and three-dimensional image reconstructions. Our results evidenced varied neuronal cell body features, number and thickness of primary shafts, dendritic branching patterns, and density and shape of dendritic spines. Based on these criteria, we propose the existence of 12 morphologically different spiny neurons in the human CeA and discuss the variability in the dendritic architecture within cellular types, including likely interneurons. Some dendritic shafts were long and straight, displayed few collaterals, and had planar radiation within the coronal neuropil volume. Most of the sampled neurons showed a few to moderate density of small stubby/wide spines. Long spines (thin and mushroom) were observed occasionally. These novel data address the synaptic processing and plasticity in the human CeA. Our morphological description can be combined with further transcriptomic, immunohistochemical, and electrophysiological/connectional approaches. It serves also to investigate how neurons are altered in neurological and psychiatric disorders with hindered emotional perception, in anxiety, following atrophy in schizophrenia, and along different stages of Alzheimer's disease.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of metacognition: Disentangling the brain circuits underlying prospective and retrospective second-order judgments through noninvasive brain stimulation 元认知的神经相关性：通过非侵入性脑神经刺激厘清前瞻性和回顾性二阶判断的大脑回路

IF 4.2 3区医学

Journal of Neuroscience Research Pub Date : 2024-04-15 DOI: 10.1002/jnr.25330

Daniele Saccenti, Andrea Stefano Moro, Sandra Sassaroli, Antonio Malgaroli, Mattia Ferro, Jacopo Lamanna

{"title":"Neural correlates of metacognition: Disentangling the brain circuits underlying prospective and retrospective second-order judgments through noninvasive brain stimulation","authors":"Daniele Saccenti, Andrea Stefano Moro, Sandra Sassaroli, Antonio Malgaroli, Mattia Ferro, Jacopo Lamanna","doi":"10.1002/jnr.25330","DOIUrl":"https://doi.org/10.1002/jnr.25330","url":null,"abstract":"Metacognition encompasses the capability to monitor and control one's cognitive processes, with metamemory and metadecision configuring among the most studied higher order functions. Although imaging experiments evaluated the role of disparate brain regions, neural substrates of metacognitive judgments remain undetermined. The aim of this systematic review is to summarize and discuss the available evidence concerning the neural bases of metacognition which has been collected by assessing the effects of noninvasive brain stimulation (NIBS) on human subjects' metacognitive capacities. Based on such literature analysis, our goal is, at first, to verify whether prospective and retrospective second-order judgments are localized within separate brain circuits and, subsequently, to provide compelling clues useful for identifying new targets for future NIBS studies. The search was conducted following the preferred reporting items for systematic reviews and meta-analyses guidelines among PubMed, PsycINFO, PsycARTICLES, PSYNDEX, MEDLINE, and ERIC databases. Overall, 25 studies met the eligibility criteria, yielding a total of 36 experiments employing transcranial magnetic stimulation and 16 ones making use of transcranial electrical stimulation techniques, including transcranial direct current stimulation and transcranial alternating current stimulation. Importantly, we found that both perspective and retrospective judgments about both memory and perceptual decision-making performances depend on the activation of the anterior and lateral portions of the prefrontal cortex, as well as on the activity of more caudal regions such as the premotor cortex and the precuneus. Combining this evidence with results from previous imaging and lesion studies, we advance ventromedial prefrontal cortex as a promising target for future NIBS studies.","PeriodicalId":16490,"journal":{"name":"Journal of Neuroscience Research","volume":"102 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0