副发光体中间神经元在自闭症谱系障碍中的作用

IF 2.9 3区医学 Q2 NEUROSCIENCES

Journal of Neuroscience Research Pub Date : 2024-10-14 DOI:10.1002/jnr.25391

Yiwei Yao, Qian Li

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引用次数: 0

摘要

作为 GABA 能中间神经元的一个重要亚型，副白质（PV）中间神经元在调节大脑皮层回路和神经网络中发挥着关键作用。PV中间神经元的发育或功能异常与自闭症谱系障碍（ASD）有关，自闭症谱系障碍是一种以社交和语言障碍为特征的神经发育障碍。在这篇综述中，我们将重点关注自闭症谱系障碍中中枢神经元的异常，包括数量和功能，并讨论自闭症谱系障碍病理中中枢神经元损伤的潜在机制。最后，我们提出了针对PV中间神经元的潜在治疗方法，如移植MGE祖细胞和利用光遗传刺激治疗ASD。

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The Role of Parvalbumin Interneurons in Autism Spectrum Disorder

As an important subtype of GABAergic interneurons, parvalbumin (PV) interneurons play a critical role in regulating cortical circuits and neural networks. Abnormalities in the development or function of PV interneurons have been linked to autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by social and language deficits. In this review, we focus on the abnormalities of PV interneurons in ASD, including quantity and function and discuss the underlying mechanisms of impairments in PV interneurons in the pathology of ASD. Finally, we propose potential therapeutic approaches targeting PV interneurons, such as transplanting MGE progenitor cells and utilizing optogenetic stimulation in the treatment of ASD.

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来源期刊

Journal of Neuroscience Research 医学-神经科学

CiteScore

9.50

自引率

2.40%

发文量

145

审稿时长

1 months

期刊介绍： The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.