Journal of Molecular Cell Biology最新文献

Correction to: Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-04-07 DOI: 10.1093/jmcb/mjaf012

引用次数: 0

Dual role of PpV in Drosophila crystal cell proliferation and survival. PpV 在果蝇晶体细胞增殖和存活中的双重作用

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-21 DOI: 10.1093/jmcb/mjae028

Wang Luo, Fang Zhang, Fangzhen Zhao, Yang Fang, Long Zhao, Ying Su

{"title":"Dual role of PpV in Drosophila crystal cell proliferation and survival.","authors":"Wang Luo, Fang Zhang, Fangzhen Zhao, Yang Fang, Long Zhao, Ying Su","doi":"10.1093/jmcb/mjae028","DOIUrl":"10.1093/jmcb/mjae028","url":null,"abstract":"Drosophila melanogaster crystal cells are a specialized type of blood cells for the innate immune process upon injury. Under normal conditions, crystal cells rarely proliferate and constitute a small proportion of fly blood cells. Notch signaling has been known to guide the cell fate determination of crystal cells and maintain their survival. Here, we reported that protein phosphatase V (PpV), the unique catalytic subunit of protein phosphatase 6 in Drosophila, is a novel regulator of crystal cell proliferation and integrity. We found that PpV proteins highly accumulated in crystal cells in the larval hematopoietic organ termed the lymph gland. Silencing PpV using RNA interference led to increased crystal cell proliferation in a Notch-independent manner and induced crystal cell rupture dependent on Notch signaling. Moreover, additive PpV prevented the rupture of crystal cells in lymph glands upon a needle injury, suggesting the involvement of PpV in wound healing. Altogether, our results indicated that PpV plays a dual role in lymph glands, preventing crystal cell proliferation to limit the cell number, as well as inhibiting crystal cell rupture to maintain their survival.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on 'Obstructive sleep apnea syndrome exacerbates NASH progression via selective autophagy-mediated Eepd1 degradation'. 关于 "阻塞性睡眠呼吸暂停综合征通过选择性自噬介导的 Eepd1 降解加剧 NASH 进展 "的评论

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-21 DOI: 10.1093/jmcb/mjae043

Jie Xiong, Suzhen Chen, Junli Liu

引用次数: 0

Gender differences in the health workforce in China: an analysis of national data. 中国卫生工作者的性别差异：全国数据分析。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-21 DOI: 10.1093/jmcb/mjae040

Wenya Yu, Xiang Liu, Hong Chen, Jiahe Tian, Meina Li, Wei Mu, Yang Ge

{"title":"Gender differences in the health workforce in China: an analysis of national data.","authors":"Wenya Yu, Xiang Liu, Hong Chen, Jiahe Tian, Meina Li, Wei Mu, Yang Ge","doi":"10.1093/jmcb/mjae040","DOIUrl":"10.1093/jmcb/mjae040","url":null,"abstract":"Gender differences in the health workforce matter for women's health and healthcare, and is also crucial for both health and economic development. Drawing on limited national gender data from China over the last 10 years, during which the country was undergoing a healthcare reform, this study dissects gender-related issues to identify existing problems, monitor progress, and develop strategies to promote change. Although women constituted the majority of health workers, they are predominantly engaged in service-oriented occupations. The gender distribution substantially differed between urban and rural primary health institutions. Moreover, significant differences in gender distribution among professional public health institutions were observed. The gender distribution of administrators varied in different types of health institutions. Women had lighter workloads because of the imbalanced distribution of specialties. Academicians comprised very few female scientists. To promote a more balanced gender distribution, policies should be developed to encourage a more reasonable division of family responsibilities. Further, equal higher education opportunities should be ensured for girls, especially in rural areas. Solutions to free more women from work-marriage-childcare conflicts and to decrease turnover rates deserve further discussion. Gender data should be highlighted and optimized to further advance gender differences among the health workforce and for women's health in China.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-17 DOI: 10.1093/jmcb/mjaf002

Ang Li, Yuanyuan Shen, Zhenyan Li, Lin Li

{"title":"Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage.","authors":"Ang Li, Yuanyuan Shen, Zhenyan Li, Lin Li","doi":"10.1093/jmcb/mjaf002","DOIUrl":"https://doi.org/10.1093/jmcb/mjaf002","url":null,"abstract":"The Wnt signaling pathway plays important roles in cardiomyocyte proliferation and cardiac regeneration after heart injury. Abnormal activation of the Wnt pathway causes a reduction of cardiomyocyte function, leading to hypertrophy, fibrosis, and heart failure. However, the mechanism through which Wnt signaling affects cardiomyocyte function during cardiac diseases is still unclear. In this study, we observed that activation of the Wnt/β-catenin pathway, but not the Wnt/Ca2+ pathway, leads to significant cytosol calcium enrichment. Such an effect can be inhibited by cycloheximide that blocks the downstream gene expression. By analyzing the transcriptome data, we found that activation of the Wnt/β-catenin pathway significantly upregulates the expression level of muscle-selective A kinase anchoring protein (mAKAP, also called AKAP6), a scaffold protein that can improve the interaction between PKA and its substrate ryanodine receptor 2 (RyR2) in cardiomyocytes. We further identified that AKAP6 is a target gene of the canonical Wnt pathway and increasing AKAP6 expression can enhance RyR2 phosphorylation by PKA, causing the sarcoplasmic reticulum calcium leakage and finally heart dysfunction. Our finding that the Wnt/β-catenin pathway affects cardiac calcium regulation via AKAP6 and RyR2 provides profound insights into heart diseases and sheds light on potential therapeutic strategies.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calciphylaxis: Ongoing Challenges and Treatment Opportunities with Mesenchymal Stem Cells.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-17 DOI: 10.1093/jmcb/mjaf009

Daoxu Wu, Shijiu Lu, Jiaying Hu, Ming Zeng, Jingjing Wu, Cui Li, Xingfang Tang, Tian Lu, Yi Zhu, Jiayin Liu, Lianju Qin, Ningning Wang

{"title":"Calciphylaxis: Ongoing Challenges and Treatment Opportunities with Mesenchymal Stem Cells.","authors":"Daoxu Wu, Shijiu Lu, Jiaying Hu, Ming Zeng, Jingjing Wu, Cui Li, Xingfang Tang, Tian Lu, Yi Zhu, Jiayin Liu, Lianju Qin, Ningning Wang","doi":"10.1093/jmcb/mjaf009","DOIUrl":"https://doi.org/10.1093/jmcb/mjaf009","url":null,"abstract":"Calciphylaxis is a rare, progressive disorder characterized by subcutaneous adipose and dermal microvascular calcifications, microthrombi, and endothelial damage. It mainly affects patients with chronic kidney disease (CKD), which is also known as calcific uremic arteriolopathy. Skin biopsy is the gold standard for diagnosis, but it is an invasive procedure. Calciphylaxis frequently results in ischemic and nonhealing ulcerations with a high mortality rate. A multidisciplinary targeted approach is the primary treatment method. Vascular calcification, which is a common complication in patients with CKD, cannot completely explain the rapid progression of calciphylaxis. This article reviews the advances in the epidemiological characteristics, risk factors, and diagnosis, including non-uraemic calciphylaxis (NUC) and visceral calciphylaxis, pathogenesis, associated animal models, and treatment of calciphylaxis. The scarcity of animal models that mimic the clinical presentation of calciphylaxis hampers the understanding of its pathogenesis. The acute effects on progressive vascular injury, including the induction of severe ischemia and inflammatory responses, have been emphasized. Actively listening to the voices of patients and their families and building a multidimensional research system with artificial intelligence technologies based on the specific molecular makeup of calciphylaxis patients will help tailor regenerative treatment strategies. Mesenchymal stem cells (MSCs) may be proposed as a novel therapy for calciphylaxis because of their regenerative effects, inhibition of vascular calcification, anti-infection and immunomodulation properties, and improvement of hypercoagulability. Safe, effective, accessible, and economical MSC strategies guided by biomarkers deserve consideration for the treatment of this devastating disease.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the nucleolar localization signal of TRMT10A and its importance for the m1G9 methylation of tRNAs in mammalian cells.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-17 DOI: 10.1093/jmcb/mjaf011

Tianyang Luo, Zhiyuan Shi, Haibin Yang, Jiafan Miao, Zilong Chang, Jie Zou, Qiang Zeng, Wenbin Wu, Yanan Jiang, Xiaoling Xie, Liu Cao, Hong Peng, Chunmei Li, Deyin Guo, Junyu Wu

引用次数: 0

Akt-elicited phosphorylation of Acapin steers cell migration.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-13 DOI: 10.1093/jmcb/mjaf010

Chunyue Wang, Jiajia Zhou, Tao Li, Shihao Du, Tetsuro Urushidani, Dongmei Wang, Yong Chen, McKay Mullen, Xinwang Cao, Shi-Yuan Cheng, Xia Ding, Fengrui Yang, Xuebiao Yao

引用次数: 0

A nomogram to predict gestational diabetes mellitus: a multi-center retrospective study.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-10 DOI: 10.1093/jmcb/mjaf008

Rui Zhang, Zhangyan Li, Nuerbiya Xilifu, Mengxue Yang, Yongling Dai, Shufei Zang, Jun Liu

{"title":"A nomogram to predict gestational diabetes mellitus: a multi-center retrospective study.","authors":"Rui Zhang, Zhangyan Li, Nuerbiya Xilifu, Mengxue Yang, Yongling Dai, Shufei Zang, Jun Liu","doi":"10.1093/jmcb/mjaf008","DOIUrl":"https://doi.org/10.1093/jmcb/mjaf008","url":null,"abstract":"While gestational diabetes mellitus (GDM) poses great threat to the health of mothers and children, there is no standard early prediction model for this disease yet. This study developed and evaluated a nomogram for predicting GDM in early pregnancy. Overall, 1824 pregnant women were randomly divided into the training and internal validation sets in the ratio of 7:3, with additional 1604 pregnant women for external validation. Multivariate logistic regression analysis was used to develop a prediction model for GDM, and a nomogram was utilized for model visualization. Risk factors in the prediction model involved age, pre-pregnancy body mass index, reproductive history, family history of diabetes, creatinine level, triglyceride level, low-density lipoprotein level, neutrophil count, and monocyte count. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision clinical analysis (DCA). The area under ROC curve (AUC) value of the model was 0.804 for the training set, and similar AUC values were obtained for the internal (0.800) and external (0.829) validation sets, verifying the stability of the model. The calibration curves showed that the probabilities of GDM predicted by the nomogram highly correlated with the observed frequency values. The DCA curves indicated that the prediction model is clinically useful, thus potentially aiding early pregnancy management in women.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel roles of ammonia in physiology and cancer.

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-03-06 DOI: 10.1093/jmcb/mjaf007

Guantong Chen, Chenxi Wang, Shuo Huang, Shibo Yang, Qiyuan Su, Yige Wang, Weiwei Dai

{"title":"Novel roles of ammonia in physiology and cancer.","authors":"Guantong Chen, Chenxi Wang, Shuo Huang, Shibo Yang, Qiyuan Su, Yige Wang, Weiwei Dai","doi":"10.1093/jmcb/mjaf007","DOIUrl":"https://doi.org/10.1093/jmcb/mjaf007","url":null,"abstract":"Ammonia, traditionally recognized as a toxic nitrogen waste product, has recently emerged as a significant player in diverse physiological processes and implicated in cancer biology. This review article provides an overview of the multifaceted impact of ammonia on cellular signaling pathways, energy metabolism, and tumor microenvironment dynamics, in particular its novel roles in neurotransmission, metabolic homeostasis, cancer cell proliferation, and immune modulation. Notably, ammonia accumulates within the tumor microenvironment, promoting non-essential amino acid synthesis, stimulating mTORC1 activation, promoting lipid synthesis, and impairing various immune cell functions, thereby promoting tumor progression. Furthermore, the potential dual role of ammonia as tumorigenic factor and cancer therapeutic target are discussed, shedding light on its complex regulatory mechanisms and clinical implications. This timely review aims to deepen our understanding of the emerging physiological and pathological roles of ammonia, offering valuable insights into its significance as a potential target for diagnostic and therapeutic interventions in cancer and beyond.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0