Journal of Molecular Cell Biology最新文献_第2页

Prospects for PARG inhibitors in cancer therapy. PARG 抑制剂在癌症治疗中的应用前景。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-22 DOI: 10.1093/jmcb/mjae050

Yangchan Hu, Yuxin Meng, Zirui Zhuang, Yuancong Li, Junjun Nan, Ning Xu, Zu Ye, Ji Jing

引用次数: 0

Structural insights into CRL2FEM1C ubiquitin ligase-mediated protein ubiquitination. CRL2FEM1C泛素连接酶介导的蛋白泛素化的结构见解。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-19 DOI: 10.1093/jmcb/mjaf016

Hualin Zhou, Mor Israel-Gueta, Xinyan Chen, Qiong Guo, Xing Liu, Itay Koren, Chao Xu

引用次数: 0

Modelling TIP60-YAP signalling in epithelial cell renewal using 3D gastric organoids. 利用三维胃类器官模拟TIP60-YAP信号在上皮细胞更新中的作用。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-16 DOI: 10.1093/jmcb/mjaf015

Hazrat Ismail, Zhen Dou, Dongmei Wang, Hengyi Shao, Xinjiao Gao, Chao Xu, Xing Liu, Chuanhai Fu, Xuebiao Yao, Xiaoyu Song

引用次数: 0

Targeting HPV for the prevention, diagnosis, and treatment of cervical cancer. 以 HPV 为目标，预防、诊断和治疗宫颈癌。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-02 DOI: 10.1093/jmcb/mjae046

Huiling Ni, Canhua Huang, Zhi Ran, Shan Li, Chunmei Kuang, Yu Zhang, Kai Yuan

{"title":"Targeting HPV for the prevention, diagnosis, and treatment of cervical cancer.","authors":"Huiling Ni, Canhua Huang, Zhi Ran, Shan Li, Chunmei Kuang, Yu Zhang, Kai Yuan","doi":"10.1093/jmcb/mjae046","DOIUrl":"10.1093/jmcb/mjae046","url":null,"abstract":"Despite advances in screening and prevention, cervical cancer (CC) remains an unresolved public health issue and poses a significant global challenge, particularly for women in low-income regions. Human papillomavirus (HPV) infection, especially with the high-risk strains, is a primary driver of cervical carcinogenesis. Emerging evidence indicates that integrating HPV testing with existing approaches, such as cervical cytology and visual inspection, offers enhanced sensitivity and specificity in CC screening. HPV infection-associated biomarkers, including HPV E6/E7 oncogenes, p16^INK4a, DNA methylation signatures, and non-coding RNAs, offer valuable insights into disease progression and the development of personalized interventions. Preventive and therapeutic vaccination against HPV, along with tertiary prevention strategies such as the use of antiviral and immune-modulating drugs for HPV-related lesions, show great clinical potential. At the mechanistic level, single-cell RNA sequencing analysis and the development of organoid models for HPV infection provide new cellular and molecular insights into HPV-related CC pathogenesis. This review focuses on the crucial roles of HPV in the prevention, diagnosis, and treatment of CC, with particular emphasis on the latest advancements in screening and disease intervention.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HDAC7 promotes cardiomyocyte proliferation by suppressing myocyte enhancer factor 2. HDAC7 通过抑制心肌细胞增强因子 2 促进心肌细胞增殖。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-02 DOI: 10.1093/jmcb/mjae044

Jihyun Jang, Mette Bentsen, Jin Bu, Ling Chen, Alexandre Rosa Campos, Mario Looso, Deqiang Li

{"title":"HDAC7 promotes cardiomyocyte proliferation by suppressing myocyte enhancer factor 2.","authors":"Jihyun Jang, Mette Bentsen, Jin Bu, Ling Chen, Alexandre Rosa Campos, Mario Looso, Deqiang Li","doi":"10.1093/jmcb/mjae044","DOIUrl":"10.1093/jmcb/mjae044","url":null,"abstract":"Postnatal mammalian cardiomyocytes (CMs) rapidly lose proliferative capacity and exit the cell cycle to undergo further differentiation and maturation. Cell cycle activation has been a major strategy to stimulate postnatal CM proliferation, albeit achieving modest effects. One impediment is that postnatal CMs may need to undergo dedifferentiation before proliferation, if not simultaneously. Here, we report that overexpression of Hdac7 in neonatal mouse CMs results in significant CM dedifferentiation and proliferation. Mechanistically, we show that histone deacetylase 7 (HDAC7)-mediated CM proliferation is contingent on dedifferentiation, which is accomplished by suppressing myocyte enhance factor 2 (MEF2). Hdac7 overexpression in CM shifts the chromatin state from binding with MEF2, which favors the transcriptional program toward differentiation, to binding with AP-1, which favors the transcriptional program toward proliferation. Furthermore, we found that HDAC7 interacts with minichromosome maintenance complex components to initiate cell cycle progression. Our findings reveal that HDAC7 promotes CM proliferation by its dual action on CM dedifferentiation and proliferation, uncovering a potential new strategy for heart regeneration/repair.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohesin ring gates are specialized for meiotic cell division. 粘合素环门专门用于减数分裂的细胞分裂。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-02 DOI: 10.1093/jmcb/mjae047

Yuanyuan Liu, Bohan Liu, Ruirui Zhang, Zixuan Zhu, Li Zhao, Ruijie Jiang, Yinghao Wang, Feifei Qi, Ruoxi Wang, Huijie Zhao, Jun Zhou, Jinmin Gao

{"title":"Cohesin ring gates are specialized for meiotic cell division.","authors":"Yuanyuan Liu, Bohan Liu, Ruirui Zhang, Zixuan Zhu, Li Zhao, Ruijie Jiang, Yinghao Wang, Feifei Qi, Ruoxi Wang, Huijie Zhao, Jun Zhou, Jinmin Gao","doi":"10.1093/jmcb/mjae047","DOIUrl":"10.1093/jmcb/mjae047","url":null,"abstract":"Cohesin is a ring complex closed with structural maintenance of chromosome 1 (SMC-1), SMC-3, and a kleisin subunit, mediating sister chromatid cohesion in mitosis and meiosis. Kleisin N- and C-terminal domains interact with SMC-3 and SMC-1, forming two distinct cohesin gates. Whether these gates are specialized for mitosis and meiosis remains elusive. Here, we create Caenorhabditis elegans mutants that express chimeric proteins swapping N- and C-terminal domains between different kleisins to investigate how these gates are specialized for different cell division programs. Replacing the meiotic REC-8 N-terminus with that of a cell division-unrelated kleisin COH-1 or the mitotic kleisin sister chromatid cohesion protein 1 (SCC-1) disrupts inter-sister chromatid cohesion and causes severe meiotic defects. Swapping the REC-8 C-terminus with that of COH-1 or SCC-1 largely retains the meiotic functions of REC-8 but causes age-related chromosome abnormalities. A specialized C-terminus is also required for the functions of SCC-1. Furthermore, point mutations in the REC-8 C-terminus cause severe meiotic defects without impairing the SMC-1-kleisin interaction, suggesting an integrated SMC-1-kleisin gate. These findings suggest the requirements for specialized cohesin gates in different biological processes.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing centromere-kinetochore core complex CENP-L/M assembly using cenpemlin. 使用 cenpemlin 探测中心粒-着丝点核心复合体 CENP-L/M 的组装。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-02 DOI: 10.1093/jmcb/mjae035

Olanrewaju Ayodeji Durojaye, Fengrui Yang, Xinjiao Gao, Felix Aikhionbare, Liangyu Zhang, Xing Liu, Xuebiao Yao

引用次数: 0

Aurora B/AIR-2 regulates sister centromere resolution and CENP-A/HCP-3 organization to prevent merotelic attachments. 极光B/AIR-2调节姐妹中心粒的分辨和CENP-A/HCP-3的组织，以防止分生附着。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-05-02 DOI: 10.1093/jmcb/mjae045

Yue Wang, Charmaine Yan Yu Wong, Karen Wing Yee Yuen

{"title":"Aurora B/AIR-2 regulates sister centromere resolution and CENP-A/HCP-3 organization to prevent merotelic attachments.","authors":"Yue Wang, Charmaine Yan Yu Wong, Karen Wing Yee Yuen","doi":"10.1093/jmcb/mjae045","DOIUrl":"10.1093/jmcb/mjae045","url":null,"abstract":"During cell division, the accurate capture of sister kinetochores that are built on the centromeres of chromosomes by microtubules emanating from opposite spindle poles governs faithful chromosome segregation. To ensure sister chromatids separate correctly, sister centromeres undergo resolution to achieve bipolar orientation prior to microtubule attachments. Failure of centromere resolution increases the frequency of merotelic attachments, with microtubules from opposite poles attaching to the same sister kinetochore, causing lagging chromosome, aneuploidy, and even cancer progression. The Aurora B-mediated tension-sensing machinery to correct erroneous kinetochore-microtubule attachments has been well studied. However, preventative mechanisms to avoid merotelic attachments that occur in the earlier mitotic stage are poorly understood. In this study, we found that inactivation of mitotic kinase Aurora B/AIR-2 increases merotelic attachments in Caenorhabditis elegans. On one hand, Aurora B/AIR-2-deficient cells exhibit a delay in the occurrence of centromere resolution and a disruption in targeting condensin II components to chromatin. On the other hand, loss of Aurora B/AIR-2 results in an increased localization of centromeric proteins CENP-A/HCP-3 and M18BP1/KNL-2 as well as the kinetochore protein MIS-12 on chromatin, which may generate ectopic kinetochores causing erroneous attachments. To conclude, this study elucidated that Aurora B/AIR-2 regulates sister centromere resolution and CENP-A/HCP-3 deposition to actively prevent merotely and chromosome instability in cells.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silencing GGH induces autophagy by increasing folate stress and production of NADH. 沉默GGH通过增加叶酸应激和NADH的产生诱导自噬。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-04-23 DOI: 10.1093/jmcb/mjaf014

Yu Li, Yuhui Du, Sijie Chen, Zhangrong Xie, Xinrui Li, Baoyue Lin, Zhiqing Zhou, Huijie Zhao, Guoan Chen

{"title":"Silencing GGH induces autophagy by increasing folate stress and production of NADH.","authors":"Yu Li, Yuhui Du, Sijie Chen, Zhangrong Xie, Xinrui Li, Baoyue Lin, Zhiqing Zhou, Huijie Zhao, Guoan Chen","doi":"10.1093/jmcb/mjaf014","DOIUrl":"https://doi.org/10.1093/jmcb/mjaf014","url":null,"abstract":"There is an inextricable link between metabolic disorders and autophagy. Gamma-glutamyl hydrolase (GGH) is a lysosomal glycoprotein that reduces intracellular folate stress by catalyzing the hydrolysis of polyglutamylated folate into transportable monoglutamate. The relationship between folate metabolism, involving the folate metabolic enzyme GGH, and autophagy has rarely been reported. In this study, we found that GGH functions as a crucial oncogene in lung adenocarcinomas. Importantly, we found that cell autophagy and autophagic cell death are induced by GGH silencing through the elevated folate stress resulting from folate metabolism and the folate metabolite nicotinamide adenine dinucleotide (NADH). By increasing the NADH/NAD + ratio, silencing GGH activates AMPK through the activation of LKB1 and CAMKK2, as well as enhanced AMP/ATP and ADP/ATP ratios, which then triggers the initiation of early autophagy, finally resulting in autophagic cell death. Taken together, our study suggests that GGH may not only serve as a prognostic marker but also play a critical role in the initiation of early autophagy. Interventions targeting GGH to regulate folate metabolism and the proportion of NADH/NAD + may have translational potential for precision therapy in human cancer.","PeriodicalId":16433,"journal":{"name":"Journal of Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the ends: Potential implications of Telomeric Repeat-Containing RNA (TERRA) for CNS Diseases. 超越终点：端粒重复序列RNA （TERRA）对中枢神经系统疾病的潜在影响。

IF 5.3 2区生物学

Journal of Molecular Cell Biology Pub Date : 2025-04-16 DOI: 10.1093/jmcb/mjaf013

Hadjer Namous, Raghu Vemuganti

引用次数: 0