Journal of Medicine and Life最新文献_第6页

Impact of type 2 diabetes mellitus on the prevalence of apical periodontitis in endodontically treated and untreated teeth. 2型糖尿病对根管治疗和未治疗牙齿根尖牙周炎患病率的影响。

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0330

Andreea Marica, Razvan Chirla, Mihai Porumb, Lucian Roman Sipos, Raluca Ortensia Cristina Iurcov, Simona Cavalu

{"title":"Impact of type 2 diabetes mellitus on the prevalence of apical periodontitis in endodontically treated and untreated teeth.","authors":"Andreea Marica, Razvan Chirla, Mihai Porumb, Lucian Roman Sipos, Raluca Ortensia Cristina Iurcov, Simona Cavalu","doi":"10.25122/jml-2024-0330","DOIUrl":"10.25122/jml-2024-0330","url":null,"abstract":"Apical periodontitis (AP) is a common dental condition that can be influenced by diabetes mellitus. This study aimed to investigate the impact of type 2 diabetes mellitus (T2DM) on the prevalence and severity of AP, considering the adequacy of endodontic treatments. A total of 180 patients selected based on specific dental criteria from a private clinic in Oradea, Romania, were included in this study. Clinical data were collected through medical records and panoramic radiographs. Statistical analyses were conducted using SPSS software, employing the Fisher test, Mann-Whitney test, and binary logistic regression to determine correlations between T2DM and AP in both endodontically treated and non-treated teeth. Additionally, we examined the relationship between diabetes and AP in teeth that received adequate root canal treatment (RCT), as well as the correlation of AP with the adequacy of endodontic treatment. Non-treated teeth were significantly more likely to have AP in patients with T2DM than in non-diabetic patients (OR = 5.3, P < 0.001). No significant difference in AP prevalence was observed between treated teeth in diabetic and non-diabetic patients. Inadequate RCT was associated with a higher incidence of AP, regardless of diabetes status (OR = 26.9, P < 0.001). The study concludes that DM significantly increases the risk of AP in untreated teeth, with diabetic patients showing a higher prevalence of AP than non-diabetic patients. However, this increased risk is not observed in adequately treated teeth. The quality of RCT is critical, as inadequate RCT is linked to a higher incidence of AP, regardless of diabetes status.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"918-925"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical, orthodontic, and prosthetic management of amelogenesis imperfecta associated with severe open bite: a case report. 外科、正畸和修复治疗严重开咬后淀粉原性不全：1例报告。

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0259

Amel Labidi, Sana Bekri, Yosra Mabrouk, Sameh Rzigui, Ines Dallel, Ramzi Moatemri, Lamia Mansour

引用次数: 0

The impact of patient support and health education on diabetes management and glycemic control. 患者支持和健康教育对糖尿病管理和血糖控制的影响。

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0290

Meshari Nawar Alotaibi, Aminah Saeed Almutairi, Fahad Abdulmajeed Alkhayal, Sulaiman Mohammed Alqahtani, Fatimah Nasser Alshehri, Mostafa Kofi

{"title":"The impact of patient support and health education on diabetes management and glycemic control.","authors":"Meshari Nawar Alotaibi, Aminah Saeed Almutairi, Fahad Abdulmajeed Alkhayal, Sulaiman Mohammed Alqahtani, Fatimah Nasser Alshehri, Mostafa Kofi","doi":"10.25122/jml-2024-0290","DOIUrl":"10.25122/jml-2024-0290","url":null,"abstract":"Diabetes mellitus is a chronic and complex medical condition that can lead to significant morbidity and mortality. Maintaining an adequate blood glucose level is important for patients with diabetes, and to improve glycemic control, patients need proper support and health education, which are essential components of comprehensive diabetes care. We used a rigorous approach based on the PRISMA and Cochrane Handbook principles, specifically focusing on randomized controlled trials (RCTs) published in English from 2005 onwards. The statistical analysis was conducted using the RevMan software. Pooled risk ratios were calculated for dichotomous data, whereas mean differences were calculated for continuous data. Heterogeneity and publication bias were also evaluated. From an initial pool of 544 records, 368 studies were examined after eliminating duplicates. Ultimately, 24 studies were deemed suitable based on the inclusion criteria. These studies involved 2437 participants in the intervention group and 2305 people in the control group. The quality assessment indicated that 41.7% of the studies were categorized as low risk, 16.7% as high risk, and 41.7% had certain concerns regarding bias. The analyses revealed noteworthy decreases in HbA1c levels in the intervention group at several time points, particularly showing improvements after 3 months. Egger's regression indicated the presence of possible publication bias. The results emphasize the crucial impact of health education and mentorship interventions on enhancing glycemic control in individuals with type 2 diabetes. Interventions focused on empowering patients proved to be especially effective in enhancing diabetes management outcomes.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"908-917"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary pleural schwannoma: a rare case report. 原发性胸膜神经鞘瘤1例报道。

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0308

Moaaz Amir, Salwa Sheikh

引用次数: 0

The correlation between the European System for Cardiac Operative Risk Evaluation and the Model for End-Stage Liver Disease in patients with coronary artery bypass graft surgery. 欧洲心脏手术风险评估系统与冠状动脉搭桥术患者终末期肝病模型的相关性

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0311

Andreea Ludusanu, Bogdan-Mihnea Ciuntu, Adelina Tanevski, Valentin Bernic, Grigore Tinica

{"title":"The correlation between the European System for Cardiac Operative Risk Evaluation and the Model for End-Stage Liver Disease in patients with coronary artery bypass graft surgery.","authors":"Andreea Ludusanu, Bogdan-Mihnea Ciuntu, Adelina Tanevski, Valentin Bernic, Grigore Tinica","doi":"10.25122/jml-2024-0311","DOIUrl":"10.25122/jml-2024-0311","url":null,"abstract":"The Model for End-Stage Liver Disease (MELD) score is a widely used tool for quantifying hepatic dysfunction, providing greater accuracy and a wider range of values compared to the Child-Turcotte-Pugh (CTP) score, being also used in prioritizing patients who are eligible for liver transplantation. This study assessed the correlation between the MELD score and the European System for Cardiac Operative Risk Evaluation II (EuroSCORE II), a reliable system for categorizing risk levels in patients undergoing cardiovascular surgery. This retrospective study analyzed data from 589 patients who underwent coronary artery bypass grafting (CABG) at the Institute of Cardiovascular Diseases 'Prof. Dr. George I.M. Georgescu' in Iași between January 2011 and December 2020. Data collected included demographical, clinical, biochemical, and intraoperative parameters. The average MELD score was 6.09 ± 4.1 (median = 5.72), and the average EuroSCORE II was 6.28 ± 8 (median = 3.85). A significant but relatively modest positive relationship was found between the MELD score and EuroSCORE II, with a correlation coefficient of 0.23 and a corresponding significance level of 0.001. This study demonstrates a positive correlation between MELD and EuroSCORE II in patients who underwent CABG. Incorporating the MELD score into the preoperative risk assessment of cardiac surgery patients could help identify high-risk individuals and guide clinical decision-making.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"926-933"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety and stress among Vietnamese health workers during the emergence of the SARS-CoV-2 Omicron variant: a cross-sectional study. SARS-CoV-2染色体变异出现期间越南卫生工作者的焦虑和压力：一项横断面研究

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0275

Nguyen Van Hoat, Hoang Quynh Lien, Tran Quang Duc, Nguyen Bich Luu, Hoang Van Minh

{"title":"Anxiety and stress among Vietnamese health workers during the emergence of the SARS-CoV-2 Omicron variant: a cross-sectional study.","authors":"Nguyen Van Hoat, Hoang Quynh Lien, Tran Quang Duc, Nguyen Bich Luu, Hoang Van Minh","doi":"10.25122/jml-2024-0275","DOIUrl":"10.25122/jml-2024-0275","url":null,"abstract":"The prevalence and contributing factors of mental health issues among health workers in Vietnam during the early 2022 Omicron wave remain underexplored. This study investigated the prevalence and factors associated with anxiety and stress among health workers in a Vietnamese hospital during this period. A cross-sectional study, conducted from February 28 to April 14, 2022, at Hanoi Medical University Hospital, assessed anxiety and stress among 754 frontline health workers using the DASS-21 questionnaire via a Google survey. Logistic regression models were used to identify factors linked to anxiety and stress. Among healthcare workers, 22% experienced stress, and 33% anxiety. Multivariable logistic regression analysis revealed that direct contact with COVID-19 patients significantly increased the likelihood of experiencing stress (OR = 2.12, P < 0.01). Additionally, discrimination from relatives and friends was associated with higher odds of having anxiety (OR = 2.45, P < 0.001). Furthermore, a heavy workload significantly increased the odds of having anxiety (OR = 1.95, P < 0.001). Lastly, a lack of support from colleagues was linked to higher odds of experiencing stress (OR = 2.77, P < 0.05). The prevalence of mental health issues among Vietnamese health workers remained significant during the initial Omicron wave. Identified factors associated with these problems hold important policy implications for enhancing pandemic preparedness in Vietnam and worldwide.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"940-947"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota profile and atopic dermatitis in the first year of life. 生命第一年肠道微生物群与特应性皮炎的关系。

Journal of Medicine and Life Pub Date : 2024-10-01 DOI: 10.25122/jml-2024-0287

Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea

{"title":"Gut microbiota profile and atopic dermatitis in the first year of life.","authors":"Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea","doi":"10.25122/jml-2024-0287","DOIUrl":"10.25122/jml-2024-0287","url":null,"abstract":"The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella species (P = 0.038), and Escherichia coli (P = 0.013), with significantly decreased levels of acidifying bacteria represented by Enterococcus species, Lactobacillus and Bifidobacterium (P < 0.05) and normal levels of Clostridium species, Candida albicans, Mould fungi and Geotrichum species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"948-952"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical biological activities and docking studies of new derivatives of acyclovir for the treatment of coronavirus disease 2019. 阿昔洛韦新衍生物治疗2019冠状病毒病的理论生物学活性及对接研究。

Journal of Medicine and Life Pub Date : 2024-09-01 DOI: 10.25122/jml-2023-0335

Muthanna Saadi Farhan

{"title":"Theoretical biological activities and docking studies of new derivatives of acyclovir for the treatment of coronavirus disease 2019.","authors":"Muthanna Saadi Farhan","doi":"10.25122/jml-2023-0335","DOIUrl":"10.25122/jml-2023-0335","url":null,"abstract":"Acyclovir is an established antiviral agent. The global emergence of the coronavirus disease 2019 (COVID-19) pandemic brought forth the necessity to investigate potential therapeutic attributes of existing drugs, including acyclovir, to combat this novel virus. The primary focus of this research was to assess the theoretical bioactivities of acyclovir derivatives and to evaluate their molecular docking capacities, thereby determining their prospective application in treating COVID-19. A set of 22 ligand molecules derived from acyclovir were carefully selected for this study. Using the one-click docking technique, these derivatives underwent molecular interactions with specific proteins sourced from the Protein Data Bank, identified by IDs 1R4L, 1S49, 1AJ6, and 1PVG. The molecular docking analysis revealed that acyclovir derivatives no. 3, 5, 8, and 14 displayed the highest docking scores and could be potential candidates as therapeutic agents against COVID-19 based on these scores. Further experimental validations are essential to establish their efficacy in clinical settings.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 9","pages":"840-847"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications and benefits of enteral feeding in children with progressive neurological disease in a palliative care service: a retrospective study. 姑息治疗服务中进行性神经疾病患儿肠内喂养的并发症和益处：一项回顾性研究

Journal of Medicine and Life Pub Date : 2024-09-01 DOI: 10.25122/jml-2024-0315

Mihaela Hizanu, Mădălina Duceac, Letiția Doina Duceac

{"title":"Complications and benefits of enteral feeding in children with progressive neurological disease in a palliative care service: a retrospective study.","authors":"Mihaela Hizanu, Mădălina Duceac, Letiția Doina Duceac","doi":"10.25122/jml-2024-0315","DOIUrl":"10.25122/jml-2024-0315","url":null,"abstract":"Palliative care for children with neurological conditions is essential to improve their quality of life and that of their family, given their uncontrollable symptoms and associated disabilities. These conditions include genetic diseases, congenital brain malformations, neurodegenerative disorders, and acquired brain injury. Enteral feeding, given directly into the gastrointestinal tract, is often necessary. A retrospective study conducted between 2018 and 2023 at the Lumina Association - Bacau Palliative Care Center analyzed data from 604 children with progressive neurological disorders out of 952 patients. These children, with an average age of 9.03 years, required enteral feeding due to swallowing disorders (48%), congenital malformations (29%), and malnutrition (23%). Feeding was performed mainly through a nasogastric tube (97.52%) and in 2.48% of cases through a gastrostomy. During this period, 4.14% of patients died from the underlying disease. The study highlights the benefits and complications of enteral feeding in these children. Although enteral feeding has been shown to be effective in maintaining nutritional status and avoiding dehydration, challenges have been identified, including digestive complications and the risk of infections in the context of palliative care.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 9","pages":"848-855"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silica nanoparticles (SiNPs) derived from melon seed husk ameliorate Ni/Al mixture-mediated cognitive impairment in rats. 从瓜皮中提取的二氧化硅纳米颗粒（SiNPs）可改善Ni/Al混合物介导的大鼠认知功能障碍。

Journal of Medicine and Life Pub Date : 2024-09-01 DOI: 10.25122/jml-2024-0019

Chidinma Promise Anyachor, Chinna Nneka Orish, Anthonet Ndidi Ezejiofor, Ana Cirovic, Aleksandar Cirovic, Baridoo Donatus Dooka, Kenneth Ezealisiji, Orish Ebere Orisakwe

{"title":"Silica nanoparticles (SiNPs) derived from melon seed husk ameliorate Ni/Al mixture-mediated cognitive impairment in rats.","authors":"Chidinma Promise Anyachor, Chinna Nneka Orish, Anthonet Ndidi Ezejiofor, Ana Cirovic, Aleksandar Cirovic, Baridoo Donatus Dooka, Kenneth Ezealisiji, Orish Ebere Orisakwe","doi":"10.25122/jml-2024-0019","DOIUrl":"10.25122/jml-2024-0019","url":null,"abstract":"This study evaluated the protective effects of silica nanoparticles (SiNPs) derived from melon seed husk ash against the neurotoxic effects of common environmental pollutants, aluminum (Al), nickel (Ni), and their combination in Wistar rats. Ninety-one male Sprague Dawley rats (220-250 g; 6-8 weeks old) were divided into 13 experimental groups. Key findings revealed that exposure to nickel, aluminum, or their combination significantly impaired spatial learning and memory, as evidenced by prolonged latency periods in treated rats. Treatment with SiNPs from melon seed husks reduced these latency periods. Increased Ni and Al levels in the frontal cortex after Ni/Al mixture exposure were mitigated by SiNPs. SiNPs also countered the reduction in iron levels caused by exposure to nickel, aluminum, and the mixture of nickel and aluminum. Moreover, SiNPs ameliorated oxidative stress by reducing MDA levels and increasing antioxidant enzyme activities. SiNPs treatment caused improved nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels and reversed elevated Aβ-42 and cyclooxygenase-2 levels, highlighting their potential neuroprotective effects. Our results demonstrated the neuroprotective effects of SiNPs from melon seed husks by attenuating metal-induced oxidative stress and inflammation, though they did not enhance cortical cholinergic activity in rats.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 9","pages":"856-867"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0