Journal of Medicine and Life最新文献

{"title":"The effect of <i>Cinnamomum cassia</i> extract on the pancreatic tissue of albino diabetic rats.","authors":"Afrah Hameed Sultan","doi":"10.25122/jml-2024-0167","DOIUrl":"10.25122/jml-2024-0167","url":null,"abstract":"<p><p><i>Cinnamomum cassia</i> (<i>C. cassia</i>) has antihyperglycemic properties. This study aimed to assess the hypoglycemic effects of the aqueous extract of <i>C. cassia</i> on the pancreatic tissue of diabetic rats, comparing histological and biochemical outcomes with those of metformin (MET) administration. A total of 42 male albino rats were divided into seven groups. Distilled water was given to healthy rats in the first group, whereas diabetic rats (DRs) induced by alloxan were treated with the same substance in the second and third groups. Rats with diabetes were given <i>C. cassia</i> treatment for 14 and 30 days in the fourth and fifth groups, whereas non-DRs received the same treatment in the sixth and seventh groups. Furthermore, MET was administered to four groups of DRs. Diabetic rats had reduced serum amylase levels and significantly increased blood glucose levels. Histological examination revealed thickening of the basement membrane in the islets of Langerhans blood channels and capillaries, as well as an increase in α- and δ-cell activity and a reduction in β-cell activity. However, administration of <i>C. cassia</i> aqueous extract caused significant alterations in most measured parameters, including increased serum amylase and decreased blood sugar levels. The daily use of <i>C. cassia</i> decreased glucose levels and induced a substantial increase in β-cell activity and a decrease in α-cell activity. Plant extracts have both regenerative and reparative properties.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"109-115"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practice of deep brain stimulation among pediatric neurology residents in Saudi Arabia.","authors":"Hanin Jaber Algethami, Munirah Hamdan Alkhrisi, Sara Ayed Alanazi, Ruba Abdelmoaty","doi":"10.25122/jml-2025-0021","DOIUrl":"10.25122/jml-2025-0021","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) is an established neurosurgical intervention for movement disorders, yet awareness among Saudi pediatric neurology residents remains limited. This study assessed the knowledge, attitudes, and perceived barriers to DBS among Saudi pediatric neurology trainees. A cross-sectional survey was conducted among pediatric neurology residents in Saudi Arabia. Participants completed a structured questionnaire assessing their familiarity with DBS indications, procedural knowledge, and training exposure. Descriptive and inferential statistics were applied. A total of 40 pediatric neurology residents participated, with a majority (87.5%) aged 26-30 years and 57.5% being women. While 65% recognized DBS as FDA-approved for adults, only 50% were aware of its pediatric approval. Knowledge of DBS targets was moderate (65%), but awareness of side effects (45%) and genetic factors influencing DBS outcomes (32.5%) was limited. Exposure to DBS-related activities was minimal, with 95% never attending a family discussion, 100% never witnessing a DBS surgery, and 80% never attending a DBS lecture. Higher residency years correlated with better DBS knowledge (<i>P</i> = 0.001), and prior patient referral was associated with higher scores (<i>P</i> = 0.028). Awareness and training in DBS among Saudi pediatric neurology residents are suboptimal. Integrating DBS education into residency curricula may improve competency and clinical decision-making.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"140-146"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of integrative psychotherapy on psychological well-being and quality of life in patients with breast cancer undergoing active treatment.","authors":"Elena Gabriela Vâlcu, Silvia Fotea, Anamaria Ciubară, Laura Florentina Rebegea","doi":"10.25122/jml-2024-0375","DOIUrl":"10.25122/jml-2024-0375","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of individual integrative psychotherapy on patients with breast cancer undergoing active treatment. A total of 23 patients diagnosed with breast cancer and treated at the Oncology Department of Sf. Ap. Andrei Clinical Emergency County Hospital, Galati, Romania, participated in the study. The psychotherapy sessions were conducted weekly for each patient, and family counseling sessions were held twice a month over 6 months. Three standardized psychological instruments were administered before and after therapy to evaluate the effectiveness of the psychotherapeutic intervention. The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-BR23 (QLQ-BR23) was used to assess disease-specific quality of life. The Beck Depression Inventory-II (BDI-II) measured the severity of depressive symptoms, while the 16 Personality Factors Questionnaire (16PF) evaluated personality traits related to coping and emotional resilience. A comparative analysis of pre-and post-therapy results revealed significant improvements across multiple domains. Participants reported an overall improvement in quality of life, with reduced breast and arm pain. Functional well-being improved, particularly in the domains of sexuality and future perspective. The study also examined the psychological impact of different treatment modalities, including surgery and chemotherapy, and their influence on emotional adaptation. Postoperative changes in quality of life were closely monitored, allowing for a comprehensive evaluation of the benefits of psychotherapy in alleviating the emotional and physical burden associated with breast cancer treatment.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"100-108"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real-world anti-inflammatory effect of SGLT2i in patients with chronic heart failure.","authors":"Alexandru Mircea Arvunescu, Ruxandra Florentina Ionescu, Silviu Ionel Dumitrescu, Ondin Zaharia, Ioan Tiberiu Nanea","doi":"10.25122/jml-2025-0011","DOIUrl":"10.25122/jml-2025-0011","url":null,"abstract":"<p><p>Inflammation plays a major role in the etiology of chronic heart failure and in inducing the progression to end-stage heart failure. This chronic inflammation, which accompanies heart failure, is not only local but also systemic and is usually in a state of low-grade but constant activation. Because there is an interrelation between systemic inflammation and neurohormonal activation, almost all anti-remodeling classes of medication have been evaluated for a potential and hidden anti-inflammatory effect. This study aimed to evaluate the effect of sodium-glucose co-trans-porter 2 inhibitors (SGLT2i) (Dapagliflozin or Empagliflozin) on inflammation measured by C-reactive protein levels, erythrocyte sedimentation rate (ESR) and fibrinogen in patients with chronic heart failure when administered together with other standard heart failure medications. We retrospectively enrolled 220 patients with chronic heart failure admitted to our hospital from January 2021 until March 2023. The study included two visits, T0 (the initial visit) and T1 (after six months), to assess if SGLT2i initiation after the first visit (T0) had an effect on the levels of inflammatory biomarkers. SGLT2i showed a reduction in fibrinogen levels, an effect that was present both in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) phenotypes. This was opposite to the dynamics of inflammatory markers in patients who did not receive SGLT2i, where the fibrinogen levels increased in HFrEF and HFpEF subgroups. SGLT2i proved an anti-inflammatory effect, showing a statistically significant reduction in fibrinogen levels in chronic heart failure, irrespective of the phenotype.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"155-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hands-on workshops on future medical students' motivation, confidence, and career aspirations: an observational study.","authors":"Dumitru Sutoi, Alexandru Cristian Cindrea, Daian Ionel Popa, Cosmin Iosif Trebuian, Carmen Williams, Maria Sutoi, Alexandru Bogdan Puscas, Adina Maria Marza, Florina Buleu, Bogdan Chiu, George Marin, Vlad Mulcutan Chis, Anda Ciontos, Luca Darie Sabau, Ovidiu Alexandru Mederle","doi":"10.25122/jml-2025-0030","DOIUrl":"10.25122/jml-2025-0030","url":null,"abstract":"<p><p>Workshops serve as an extrinsic motivational tool for medical students, enhancing their knowledge, self-confidence, and practical skills. These workshops could have a similar impact on future medical students, who may have various reasons for their aspiration to follow a career in medicine. The main goal of our study was to demonstrate that participating in hands-on workshops boosts the motivation of future medical students to work toward a career in medicine. The second goal was to evaluate the amount of first aid assistance participants provided, their willingness to deliver first aid, and the impact on self-perceived confidence in their practical skills after attending this experience. Workshops were conducted across multiple cities, engaging 540 participants between March and November 2024. At year-end, a custom questionnaire assessed their motivation, self-confidence, and medical career aspirations. A total of 186 participants met the inclusion criteria and were analyzed. Participants had a median age of 18.5 years (18-19.75) and graduated high school (55.4%). Most chose to follow medicine due to a strong desire to help or an exclusive desire to practice in this field. Significant increases in respondents' Likert scale ratings were observed before and after the workshops (<i>P</i> < 0.001, Wilcoxon signed-rank test). No significant differences were found when comparing responses between different workshops. In conclusion, the results of the motivating factors align with the trends in other high-income countries. Also, workshops serve as an extrinsic motivational source, increasing students' self-confidence and theoretical and practical knowledge.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"147-154"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The short-term follow-up of patients with diabetes mellitus presenting with COVID-19.","authors":"Delia-Andreea Lespezeanu, Alin Kraft, Cosmin Moldovan, Dan Ungureanu, Nicolae Bacalbasa","doi":"10.25122/jml-2025-0027","DOIUrl":"10.25122/jml-2025-0027","url":null,"abstract":"<p><p>The COVID-19 pandemic has disproportionately affected individuals with diabetes mellitus (DM), significantly increasing their risk of adverse outcomes. This retrospective study aimed to explore the underlying factors contributing to the heightened vulnerability of individuals with DM to severe COVID-19. We reviewed medical records of patients diagnosed with DM from August 2020 to August 2022 and identified 60 equally divided into two groups. Group A (<i>n</i> = 30) included those diagnosed with an associated COVID-19 infection, while Group B (<i>n</i> = 30) served as the control group without a COVID-19 infection. Inflammatory biomarkers, venous blood glucose levels, and other parameters were assessed at hospital admission and again after a 14-day treatment period. Statistical analysis confirmed a strong association between diabetes and COVID-19 infection. In COVID-19 patients treated with Empagliflozin, correlations were observed between IL-1, TNF-alpha, IL-6, and blood glucose levels. Patients in Group B did not show significant improvements in inflammatory markers or blood glucose control. In contrast, in the first group, better correlations between interleukin levels and blood glucose were demonstrated, suggesting a higher success rate for that treatment. Our findings indicate that while Empagliflozin had limited efficacy in managing long-term diabetes-related complications, it might offer significant benefits in the acute phase of illness.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"116-124"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise, myonectin response, and insulin resistance among overweight, obese and healthy individuals: a systematic review and narrative synthesis.","authors":"Aysha Mohamed Mohamed Alsahi Alzaabi, Ramprasad Muthukrishnan, Marwan Ismail, Praveen Kumar Kandakurthi, Satheeskumar Durairaj, Shanmugam Sukumar, Kumaraguruparan Gopal","doi":"10.25122/jml-2024-0277","DOIUrl":"10.25122/jml-2024-0277","url":null,"abstract":"<p><p>Myonectin, a novel muscle-derived peptide or myokine, has been implicated in glucose and lipid homeostasis through its autocrine, paracrine, and endocrine functions. This review aimed to explore the impact of structured exercise interventions on myonectin levels and insulin resistance indicators in healthy individuals and those living with overweight or obesity. We performed a search of PubMed, Science Direct, CINAHL, TRIP Database, Cochrane Library, and Google Scholar for studies published until July 2022. The key terms used were \"prediabetes\", \"overweight\", \"obesity\", \"myonectin\", \"Complement 1q / tumor necrosis factor-related protein 5 (CTRP5 or C1qTNF5)\", \"erythroferrone\", and \"exercise\". Eight studies investigated the effects of exercise on myonectin levels and insulin resistance, measured through the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), in individuals who were overweight or obese, while six studies focused on those without these conditions. After data extraction, narrative qualitative synthesis and risk of bias analysis were performed. Findings indicate that structured aerobic or combined aerobic and resistance training at moderate intensity over 8-12 weeks led to significant increases in myonectin levels and reductions in insulin resistance, particularly among women who were overweight or obese. However, data was limited by heterogeneous age and gender groups' metabolic profiles and variability in exercise protocols. Myonectin response to exercise in healthy adults remains unclear due to baseline metabolic variability, though some improvements in the glucose-insulin axis were noted. This review suggests that myonectin may serve as a valuable biomarker to assess the impact of exercise on insulin sensitivity in individuals at risk of diabetes with overweight or obesity.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"73-89"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of endometriosis on patients' quality of sexual life.","authors":"Mihaela Amza, Romina-Marina Sima, Ileana-Maria Conea, Tina-Ioana Bobei, Fernanda-Ecaterina Augustin, Liana Pleş","doi":"10.25122/jml-2024-0262","DOIUrl":"10.25122/jml-2024-0262","url":null,"abstract":"<p><p>The objective of this study was to evaluate the prevalence and impact of female sexual dysfunction and sexual distress in women with endometriosis. This retrospective, analytical, observational study included patients diagnosed with ovarian endometriomas who underwent surgery to remove endometriosis lesions. The impact of endometriosis on the quality of sexual lives of patients before and after surgery was analyzed using a self-administered questionnaire consisting of 20 closed-ended questions. The study included 70 patients with endometriosis with a mean age of 32.70 ± 7.39 years. The majority of patients reported that the diagnosis of endometriosis negatively influenced their quality of sexual life (65.7%). Most patients (88.6%) experienced dyspareunia before surgery. A total of 36 patients (51.4%) stated that they had difficulty in obtaining pleasure during sexual intercourse. The intensity of dyspareunia had an important negative effect on the quality of sexual life of the patients. Following surgery, most patients (81.4%) reported improvements in their sexual quality of life, with a statistically significant reduction in pain intensity during intercourse (<i>P</i> < 0.001). These findings suggest that endometriosis may contribute to sexual avoidance and diminished pleasure. Surgical removal of endometriosis lesions significantly improved sexual quality of life, particularly by reducing dyspareunia intensity.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"90-93"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotting the clues: cluster of differentiation-a perspective of immune response intertwined with dysautonomia in colon cancer - a prospective cohort study.","authors":"Diana-Theodora Morgos, Lucian-George Eftimie, Horia Nicolae, Remus Iulian Nica, Constantin Stefani, Daniela Miricescu, Adrian Tulin, Florin Mihail Filipoiu","doi":"10.25122/jml-2025-0014","DOIUrl":"10.25122/jml-2025-0014","url":null,"abstract":"<p><p>Dysautonomia, a parasympathetic-sympathetic imbalance, has clinical and public health consequences. Colon neoplasm is linked to dysautonomia through a complex interplay between the two conditions. In this prospective cohort study, we evaluated 18 patients divided into three groups: six patients with both colon cancer and dysautonomia, six patients with colon cancer without dysautonomia, and six patients with dysautonomia only (control group). Dysautonomia was defined by the presence of orthostatic hypotension, a non-increased or dropped heart rate, and various autonomic symptoms. During abdominal surgery, tissue samples from the celiac ganglion were collected and analyzed using immunohistochemistry (IHC). Our findings revealed a significant correlation between IHC marker expression in colon cancer and dysautonomia (control) (r = 0.927, <i>P</i> = 0.008). ANOVA results confirmed that the model was significant and that the dysautonomia group (control) had a significant effect on the independent variables (colon cancer or colon cancer + dysautonomia). The study proposes that a shared immunological mechanism underlies both dysautonomia and colon cancer, suggesting that the immune system plays a crucial role in the development or progression of these two conditions.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"125-132"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen metabolism and incisional hernia recurrence: a comparative study between oncologic and non-oncologic patients.","authors":"Vlad Paic, Petru Adrian Radu, Anca Tigora, Mihai Zurzu, Mircea Bratucu, Costin Pasnicu, Alexandra Purcaru, Petru Stavar, Valeriu Surlin, Dan Cartu, Daniela Marinescu, Traean Burcos, Florian Popa, Victor Strambu, Dragos Garofil","doi":"10.25122/jml-2025-0028","DOIUrl":"10.25122/jml-2025-0028","url":null,"abstract":"<p><p>A significant challenge in incisional hernia repair is the recurrence risk, which may be influenced by the structural integrity of collagen within the tissue. This study investigated the role of collagen metabolism in hernia recurrence by comparing oncologic and non-oncologic patients, focusing on collagen I/III ratios and their impact on tissue strength and surgical outcomes. A comparative clinical study was conducted on 50 patients (30 oncologic, 20 non-oncologic) undergoing incisional hernia repair. Collagen composition was analyzed using stereomicroscopy, and statistical comparisons were performed using independent <i>t</i>-tests and chi-square tests to assess differences in recurrence rates and tissue properties between groups. Results indicated that oncologic patients had significantly lower collagen I/III ratios (<i>P</i> < 0.001), suggesting structurally weaker tissue, which correlated with higher recurrence rates (18% in oncologic vs. 10% in non-oncologic patients). Furthermore, the sublay mesh repair technique demonstrated superior outcomes with lower recurrence rates compared to onlay repair, reinforcing its role in mitigating complications associated with poor collagen integrity. The study results indicated that oncologic patients had impaired collagen remodeling, contributing to an increased risk of recurrence. Individualized surgical strategies, including targeted preoperative interventions, may help mitigate these risks and enhance patient outcomes. Given the observed disparities, further research is warranted to explore targeted therapeutic approaches that enhance tissue quality and improve long-term surgical success in high-risk patient populations.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 2","pages":"133-139"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}