Journal of Medicine and Life最新文献

Efficacy of dietary and lifestyle interventions in obesity management: a therapeutic protocol at the Diabetes Department, Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. 饮食和生活方式干预在肥胖管理中的功效：罗马尼亚布加勒斯特Marius Nasta肺病研究所糖尿病科的治疗方案。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0417

Oana-Andreea Parlițeanu, Simona Carniciu, Alina Spinean, Cristiana Voineag, Beatrice Mahler

{"title":"Efficacy of dietary and lifestyle interventions in obesity management: a therapeutic protocol at the Diabetes Department, Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania.","authors":"Oana-Andreea Parlițeanu, Simona Carniciu, Alina Spinean, Cristiana Voineag, Beatrice Mahler","doi":"10.25122/jml-2024-0417","DOIUrl":"https://doi.org/10.25122/jml-2024-0417","url":null,"abstract":"The primary objective of this study was to underline the importance of comprehensive medical education in the management of obesity. In clinical practice, patients frequently encounter challenges in achieving weight-related goals. Given that obesity is a major cause of global mortality, we aimed to evaluate the effectiveness of implementing targeted educational interventions on patient outcomes. To this end, we developed a specific dietary plan and educational materials for lifestyle modification administered to 44 patients in the Diabetes Department of Marius Nasta Institute of Pneumophthisiology in Bucharest, Romania. Assessments were conducted at baseline and after a three-month intervention period. The total body weight loss was 11%. BMI reductions were reflected in the redistribution of obesity types. The number of overweight individuals increased from 10 men (22.72%) to 13 men and 5 women, totaling 18 individuals (40.90%, with 29.54% men and 11.36% women). Blood glucose values dropped by 5%, and levels of HbA1c dropped by 0.4% from baseline to follow-up. The SAS severe group went down from 16 patients to 10 patients, and there was an increase in the mild Sleep Apnea Syndrome (SAS) group, increasing from 8 to 14, resulting in a 13.63% overall increase. Our findings indicate that enhanced engagement by the therapeutic team, combined with detailed educational resources and adequate time for their comprehension, improved patient health outcomes, led to weight reduction and a reduction in the severity of comorbidities such as hypertension, dyslipidemia, and sleep apnea, which translated to improved quality of life.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"208-213"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic assessment of the inflammatory response in military personnel: a pilot study on ΔNLR and composite markers in operational environments. 军事人员炎症反应的动态评估：作战环境中ΔNLR和复合标志物的试点研究。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0056

Florina-Diana Mihai, Emil-Tiberius Trasca, Dumitru Radulescu, Patricia-Mihaela Radulescu, Razvan Mercut, Elena-Irina Caluianu, Eleonora Daniela Ciupeanu-Calugaru, Dan Marian Calafeteanu, Georgiana-Andreea Marinescu, Suzana Danoiu

{"title":"Dynamic assessment of the inflammatory response in military personnel: a pilot study on ΔNLR and composite markers in operational environments.","authors":"Florina-Diana Mihai, Emil-Tiberius Trasca, Dumitru Radulescu, Patricia-Mihaela Radulescu, Razvan Mercut, Elena-Irina Caluianu, Eleonora Daniela Ciupeanu-Calugaru, Dan Marian Calafeteanu, Georgiana-Andreea Marinescu, Suzana Danoiu","doi":"10.25122/jml-2025-0056","DOIUrl":"https://doi.org/10.25122/jml-2025-0056","url":null,"abstract":"In this pilot study, we investigated immune alterations in 178 military personnel exposed to extreme operational stress. We focused on the neutrophil-to-lymphocyte ratio (NLR) and its change (ΔNLR) alongside composite inflammatory indices- Systemic Inflammation Response Index (SIRI), Systemic Immune-Inflammation Index (SII), and Inflammatory Index Cumulative (IIC). Blood analyses performed before and after deployment revealed a significant post-mission increase in NLR (1.9671±±±0.9174 vs. 1.6079±±±0.4973 pre-deployment), yielding an average ΔNLR of 0.3592±±±0.7642 (P < 0.0001). While basophil counts and several biochemical markers remained stable, notable changes in neutrophils and composite indices suggest a complex inflammatory activation. Importantly, correlation analyses confirmed that despite marked shifts in absolute values, the relative relationships between pre- and post-deployment measurements (e.g., NLR: r = 0.5533, P < 0.0001) were maintained. These findings imply that ΔNLR, together with SIRI, SII, and IIC, may serve as valuable biomarkers for dynamically monitoring the inflammatory response in military contexts, thereby enabling early identification of individuals at increased inflammatory risk.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"257-264"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced rehabilitation after surgery: principles in the treatment of emergency complicated colorectal cancers - a narrative review. 加强术后康复：急诊复杂结直肠癌治疗原则综述

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0049

Alexandra-Ana Mihailescu, Sebastian Gradinaru, Alin Kraft, Corneliu-Dan Blendea, Bogdan-Sorin Capitanu, Stefan Ilie Neagu

{"title":"Enhanced rehabilitation after surgery: principles in the treatment of emergency complicated colorectal cancers - a narrative review.","authors":"Alexandra-Ana Mihailescu, Sebastian Gradinaru, Alin Kraft, Corneliu-Dan Blendea, Bogdan-Sorin Capitanu, Stefan Ilie Neagu","doi":"10.25122/jml-2025-0049","DOIUrl":"https://doi.org/10.25122/jml-2025-0049","url":null,"abstract":"Enhanced Recovery After Surgery (ERAS) protocols are used in elective colorectal surgeries and have shown improved recovery for many patients. However, using these protocols in emergency colorectal surgery, especially in complicated cases of obstructive colorectal cancer, is still debated. This review examined the ERAS principles that can be adapted for emergencies. We reviewed the literature on applying ERAS principles in emergency colorectal cancer surgery. We analyzed key strategies used before, during, and after surgery. The aim of ERAS in emergency colorectal surgery is to reduce physical stress from urgent surgical conditions. Before surgery, the focus should be on early patient recovery, managing blood sugar levels, and providing patient education when possible. Minimally invasive techniques, careful fluid management, and effective pain relief during surgery are intraoperative key points. After surgery, early feeding, patient mobilization, and minimizing the use of medical devices are encouraged. Studies have shown that using ERAS in emergencies can lower mortality, reduce hospital stays, and influence patient recovery rates, although it may lead to higher initial costs. Still, following ERAS in emergencies is inconsistent due to logistical issues and patient health changes. More people are starting to recognize the benefits of ERAS in obstructive colorectal cancer surgery. Although there is less evidence compared to elective procedures, new studies suggest that organized steps for care can improve patient outcomes. Further research is needed to improve ERAS emergency protocols and identify patients suitable for this approach so that healthcare resources can be used better.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"179-187"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of concurrent HIV infection in the course and management of Crohn's disease. 克罗恩病过程中并发HIV感染的挑战和管理。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0359

Lamyaa Mattar, Husna Irfan Thalib, Meral Alnuwaimi, Hanin Alsaadi, Huda Ahmed Allouji, Jena Alyafei, Layan Alshowiman, Nuran Alsobyani, Fatma El Sayed Hassan

{"title":"Challenges of concurrent HIV infection in the course and management of Crohn's disease.","authors":"Lamyaa Mattar, Husna Irfan Thalib, Meral Alnuwaimi, Hanin Alsaadi, Huda Ahmed Allouji, Jena Alyafei, Layan Alshowiman, Nuran Alsobyani, Fatma El Sayed Hassan","doi":"10.25122/jml-2024-0359","DOIUrl":"https://doi.org/10.25122/jml-2024-0359","url":null,"abstract":"Crohn's disease (CD) is a chronic transmural bowel inflammation with a multifactorial etiology involving genetic predisposition and immune dysregulation in response to environmental triggers. In patients with human immunodeficiency virus (HIV), an already compromised immune system further complicates the progression and management of CD, creating unique therapeutic challenges. Probiotics have recently gained attention as a potential therapeutic option for CD, especially due to their role in modulating the gut microbiota. However, their effectiveness in patients with HIV, especially in enhancing and maintaining remissions, remains underexplored. This review aimed to examine how HIV infection influences the course of inflammatory bowel disease (IBD) and its impact on CD management strategies. A systematic literature search was conducted using Google Scholar, PubMed, Springer, and Web of Science to identify studies on patients with HIV and CD. HIV infection significantly alters the progression and management of CD due to its impact on the immune system. The immunosuppressed state of patients with HIV can complicate both the diagnosis and treatment of CD, often requiring adjustments in therapeutic approaches, necessitating a careful, tailored approach.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical and non-surgical management of spondylolisthesis: a comprehensive review. 脊柱滑脱的手术和非手术治疗：全面回顾。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0039

Dana-Georgiana Nedelea, Diana Elena Vulpe, Florentina Gherghiceanu, Bogdan Sorin Capitanu, Serban Dragosloveanu, Ioan Cristian Stoica

{"title":"Surgical and non-surgical management of spondylolisthesis: a comprehensive review.","authors":"Dana-Georgiana Nedelea, Diana Elena Vulpe, Florentina Gherghiceanu, Bogdan Sorin Capitanu, Serban Dragosloveanu, Ioan Cristian Stoica","doi":"10.25122/jml-2025-0039","DOIUrl":"https://doi.org/10.25122/jml-2025-0039","url":null,"abstract":"Spondylolisthesis is a spinal condition characterized by the forward or backward displacement of a vertebral body, most commonly affecting the lower lumbar spine. It can be classified into different types, with isthmic and degenerative being the most prevalent. Early diagnosis is essential to initiate appropriate treatment based on symptom severity, degree of slippage, and neurological deficits. Non-surgical management is the first-line approach for low-grade spondylolisthesis (Grade I-II) and includes physical therapy, activity modification, pain management with nonsteroidal anti-inflammatory drugs or epidural steroid injections, and, in some cases, bracing. While most patients experience symptom relief with conservative treatment, those with progressive neurological deficits, severe pain, or significant instability may require surgery. Surgical options typically include decompression for nerve compression and fusion to stabilize the spine. The choice between decompression alone and decompression with fusion remains controversial, particularly in degenerative spondylolisthesis without initial instability. Posterior lumbar interbody fusion and transforaminal lumbar interbody fusion are the most performed techniques, with minimally invasive surgery gaining popularity due to its less aggressive impact on tissues and faster recovery. Long-term follow-up is necessary to monitor for complications such as adjacent segment disease, pseudarthrosis, or reoperation rate. Advances in imaging, surgical navigation, and regenerative medicine are important for the future of spondylolisthesis treatment, but current management remains centered on optimizing patient outcomes through individualized care and evidence-based treatment selection.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"196-207"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches. 单胺类神经递质转运障碍的比较研究：机制、临床表现和治疗方法。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0398

Rand Redwan Al Sari, Husna Irfan Thalib, Syeda Sobiah Imad, Sariya Khan, Shyma Haidar, Bayan Mohammed Khair Al Zoabi, Sahar Hamed Fadda, Samratul Fuadah, Hassan Abu Alwan, Abdullah Alghobaishi

{"title":"A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches.","authors":"Rand Redwan Al Sari, Husna Irfan Thalib, Syeda Sobiah Imad, Sariya Khan, Shyma Haidar, Bayan Mohammed Khair Al Zoabi, Sahar Hamed Fadda, Samratul Fuadah, Hassan Abu Alwan, Abdullah Alghobaishi","doi":"10.25122/jml-2024-0398","DOIUrl":"https://doi.org/10.25122/jml-2024-0398","url":null,"abstract":"Neurotransmitters play important roles in brain function, influencing cognition, movement, and behavior. Disruption in neurotransmitter biosynthesis, expression, transport, or function due to genetic mutations can lead to various neurological and psychiatric disorders with variable age of onset. Catecholamines like dopamine, norepinephrine, epinephrine, and serotonin are key monoamines transported by specific transporters, including the dopamine transporter (DAT) and the vesicular monoamine transporter 2 (VMAT2). Disorders that involve monoamine neurotransmitter transport include dopamine transporter deficiency syndrome (DTDS) and brain dopamine-serotonin vesicular disorders (PKDYS2). These rare syndromes manifest with movement disorders and neuropsychiatric symptoms. DTDS results from a mutation in the SLC6A3 gene affecting dopamine reuptake, while PKDYS2 involves a mutation in the SLC18A2 gene impairing the transport of dopamine and serotonin. This review provides a comparative analysis of the diagnostic approaches, the management strategies, and the outcomes for these distinct disorders.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and awareness of the health effects of electronic cigarette among college students. 大学生对电子烟健康影响的认知和意识。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0016

Saleh Khateeb, Dana Alsuqaie, Sama Sobahi, Danah Muminah, Laila Alyafi, Taif Alotbi

{"title":"Knowledge and awareness of the health effects of electronic cigarette among college students.","authors":"Saleh Khateeb, Dana Alsuqaie, Sama Sobahi, Danah Muminah, Laila Alyafi, Taif Alotbi","doi":"10.25122/jml-2025-0016","DOIUrl":"https://doi.org/10.25122/jml-2025-0016","url":null,"abstract":"Electronic cigarettes (e-cigarettes) are nicotine delivery devices promoted as a safer alternative to traditional smoking; however, their long-term health effects remain uncertain. Their use is rapidly increasing worldwide, particularly among young adults. In Jeddah, Saudi Arabia, there is limited information on e-cigarette usage among college students. This study aimed to assess the level of knowledge and awareness regarding the health effects of e-cigarettes among college students in Jeddah through a cross-sectional, survey-based study conducted in 2024 with 438 participants. Data were collected using a pre-validated self-administered questionnaire distributed via various social media platforms. Categorical variables were compared using the chi-square test. Results indicated that 54.8% of respondents reported previous smoking experience. Among the participants, 29.7% believed that e-cigarettes are an effective smoking cessation method, 50.5% viewed them as a potential replacement for traditional cigarettes, and 43.2% considered e-cigarettes a gateway to conventional smoking. Overall, 39.3% of respondents demonstrated good knowledge about e-cigarettes, with significant differences observed between age groups, genders, smoking experience (P < 0.001), and educational levels (P < 0.002). Additionally, 54.3% of respondents expressed a negative attitude toward e-cigarettes, with statistically significant differences across groups (P < 0.001). Given the relatively high prevalence of smoking among college students in Jeddah and their overall insufficient knowledge about e-cigarettes, these findings underscore the urgent need to raise awareness about the risks associated with e-cigarette use and to implement appropriate regulatory measures.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"235-245"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking surgical barriers: ERAS in action in Romania. 打破手术障碍：ERAS在罗马尼亚的应用。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0034

Victor Constantin Ștefănescu, Andreea-Marilena Ionescu, Sabrina Florentina Florea, Mihai Alexandru Vasile, Vlad Bătăilă, Daniel Cochior

{"title":"Breaking surgical barriers: ERAS in action in Romania.","authors":"Victor Constantin Ștefănescu, Andreea-Marilena Ionescu, Sabrina Florentina Florea, Mihai Alexandru Vasile, Vlad Bătăilă, Daniel Cochior","doi":"10.25122/jml-2025-0034","DOIUrl":"https://doi.org/10.25122/jml-2025-0034","url":null,"abstract":"Implementing Enhanced Recovery After Surgery (ERAS) protocols presents challenges for healthcare systems, particularly for patients undergoing complex surgeries. Though ERAS effectively reduces postoperative complications and hospital stays, its implementation varies. Our hospital adopted the ERAS protocol in 2020. This study details specific ERAS components implemented in our clinic, emphasizing surgical and anesthetic strategies. We describe preoperative, intraoperative, and postoperative phases and analyze the evidence for each component's integration. Additionally, we highlight the specific challenges faced in Romania, such as funding limitations, resource constraints, and reluctance among healthcare professionals. We conducted a prospective study of 147 patients with colorectal cancer treated from 2020 to 2023, detailing the perioperative care phases and supporting evidence for protocol components. The methodology was refined to account for potential confounding factors by ensuring consistency in patient selection criteria and perioperative management. Despite ERAS's advantages, patients and staff resisted its implementation. In Romanian hospitals, colorectal surgery uses ERAS only in limited cases due to inadequate funding, insufficient medical personnel, logistical challenges, and a lack of awareness or skepticism among healthcare professionals and patients. The study presents specific clinical outcomes, including length of hospital stay (LOS), postoperative complications, and readmission rates among ERAS patients. We recommend expanding medical networks and utilizing advanced technologies like telemedicine services and home-based care to improve ERAS protocol adherence. Furthermore, educational programs are essential to increase awareness and compliance with ERAS principles among patients and healthcare providers.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"229-234"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroencephalographic aspects and phenotypic characteristics in children with autism. 自闭症儿童的脑电图特征和表型特征。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0053

Alexandru Capisizu, Leon Zăgrean, Adriana Sorina Capisizu

{"title":"Electroencephalographic aspects and phenotypic characteristics in children with autism.","authors":"Alexandru Capisizu, Leon Zăgrean, Adriana Sorina Capisizu","doi":"10.25122/jml-2025-0053","DOIUrl":"https://doi.org/10.25122/jml-2025-0053","url":null,"abstract":"Autism is a severe neurodevelopmental disorder that affects many individuals around the world, with a constantly increasing prevalence. The association between autism and electroencephalographic (EEG) abnormalities in children suggests a worse evolution of clinical features. A retrospective study was conducted, including 101 children with autism who underwent clinical and neurological examination and wake electroencephalography. This study aimed to examine EEG abnormalities in children with autism, identify phenotypic characteristics associated with these abnormalities, asses their clinical relevance, and determine potential phenotypic correlations. The results showed that 10.89% of the patients in the study presented EEG abnormalities, similar to those of other studies that used wake EEG. Of these patients, 18.18% presented epileptic-type discharges, such as spike and wave complexes, and 81.81% presented non-epileptic-type abnormalities, such as bursts of slow waves, generalized or focal. Regarding the phenotypic profile of the patients with EEG abnormalities, 45.45% had a positive family history, 63.63% presented with dysmorphic features and 27.27% presented with gait disturbance. This study shows that some children with autism present multiple EEG abnormalities and diverse phenotypic traits in terms of personal and family history, dysmorphic features, and neurological examination. Identifying EEG abnormalities can improve clinical decisions with complex treatment and monitoring of co-occurring conditions like epilepsy. The use of accessible, effective, and noninvasive assessment tools, such as EEG recordings and neurological examinations in children with autism, can provide valuable support for improved case management.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"246-256"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of short- and mid-term benefits of re-operative surgery in iatrogenic spondylolisthesis cases. 医源性椎体滑脱再手术的中短期效益评价。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0048

Dana-Georgiana Nedelea, Diana Elena Vulpe, Serban Dragosloveanu, Ioan Cristian Stoica

{"title":"Evaluation of short- and mid-term benefits of re-operative surgery in iatrogenic spondylolisthesis cases.","authors":"Dana-Georgiana Nedelea, Diana Elena Vulpe, Serban Dragosloveanu, Ioan Cristian Stoica","doi":"10.25122/jml-2025-0048","DOIUrl":"https://doi.org/10.25122/jml-2025-0048","url":null,"abstract":"Laminectomy is a widely used surgical approach in patients with spinal canal stenosis but can result in biomechanical changes leading to iatrogenic spondylolisthesis. While some factors, such as surgical technique and achievement of spinal stability, are key contributors, patient-specific factors remain underexplored. Our study included 64 patients with diagnosed iatrogenic spondylolisthesis following previous spinal surgery. They were stratified into male and female groups, and clinical parameters such as the body mass index (BMI), fatty infiltration of the paraspinal muscles (assessed via Goutallier classification), pain scores (Visual Analogue Scale - VAS), and functional outcomes (Oswestry Disability Index - ODI) were analyzed pre-and postoperatively. The cohort consisted of 19 men and 45 women, with a mean age of 63.7 ± 10.82 years. There was a statistically significant difference in BMI, with higher values in women than men (30.16 ± 2.73 vs. 28.11 ± 2.71, P = 0.0078). Fatty infiltration of the paraspinal muscles was also more pronounced in women, with significant differences observed in Goutallier grades 2 and 3 (P = 0.007). While no differences were noted in surgery duration or hospital stay, males experienced greater intraoperative blood loss (P = 0.0442). Both groups had similar short- and mid-term pain and functional improvement, with no statistically significant differences in the VAS or ODI scores. In conclusion, patients with iatrogenic spondylolisthesis showed sex-based differences in BMI and fatty infiltration of the paraspinal muscles in patients. These factors did not influence short- and mid-term functional recovery but may play a key role in disease progression and surgical outcomes.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"223-228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0