Journal of Medicine and Life最新文献

{"title":"PD-L1 Expression and Tumor Microenvironment Dynamics in Diffuse Large B-Cell Lymphoma: Immunophenotypic Insights.","authors":"Georgian Halcu, Filip Cristian Mureșan, Andrei Niculae, Anca Evsei-Seceleanu, Mihai-Emilian Lapadat, Mihai Adrian Cerbu, Mihail Ceausu","doi":"10.25122/jml-2025-0078","DOIUrl":"10.25122/jml-2025-0078","url":null,"abstract":"<p><p>Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of B-cell non-Hodgkin lymphoma (NHL) and is characterized by significant biological and clinical heterogeneity. The programmed death 1 (PD-1)/ programmed death-ligand 1 (PD-L1) immune checkpoint pathway plays a crucial role in tumor immune evasion; however, its diagnostic and prognostic relevance in DLBCL remains unclear. We retrospectively analyzed 66 cases of DLBCL diagnosed between 2017 and 2024 at a single institution. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues using antibodies against PD-L1, PD-1, CD4, CD8, and CD68. Clinical data and histopathological features were correlated with marker expression. Statistical analyses were conducted using IBM SPSS 25, with a significance level set at <i>P</i> < 0.05. PD-L1 expression (greater than 1%) in tumor cells was infrequent (6/66 cases), while immune cell PD-L1 positivity was prevalent (39/66 cases). PD-1 positivity was observed in five tumor samples and 40.9% of stromal immune cells. A significant association was found between tumoral PD-L1 expression and histological subtype (<i>P</i> = 0.015), with anaplastic variants showing higher expression levels. Positive PD-1 expression in immune cells was significantly associated with female gender (<i>P</i> = 0.044). High CD68 expression correlated with a lower Ann Arbor stage (<i>P</i> = 0.040) and tumor morphology (<i>P</i> = 0.010). CD4 and CD8 expression levels showed no significant correlations with clinicopathological features. PD-L1 and PD-1 expression patterns in DLBCL highlight their potential relevance for immune evasion and prognosis, particularly in anaplastic variants. The tumor microenvironment, especially macrophage infiltration, plays a complex role in disease progression. Further studies are needed to validate these findings and investigate therapeutic implications.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 5","pages":"463-471"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of musculoskeletal disorders in patients with chronic dyspnea.","authors":"Kinga Vindis, Katalin Babeș","doi":"10.25122/jml-2025-0080","DOIUrl":"10.25122/jml-2025-0080","url":null,"abstract":"<p><p>Dyspnea, regardless of cause, is frequently associated with neuromuscular disorders. Many adults with chronic dyspnea associated with neuromuscular disorders have associated heart or lung disease. This study aimed to identify the association between chronic dyspnea of different etiologies and musculoskeletal disorders identified at presentation to establish a rehabilitation program. This prospective study was carried out in the Medical Rehabilitation Department of Dr. Pop Mircea Municipal Hospital in Marghita and included 163 consecutive patients with chronic dyspnea of different etiologies. The analysis showed no significant difference in the risk of musculoskeletal disorders between men and women (RR = 1.0090). Similarly, we found no significantly increased risk of musculoskeletal disorders in obese individuals compared to overweight (RR = 1.1223; 95% CI, 0.9648-1.3055; z = 1.495; <i>P</i> = 0.135) or normal-weight individuals (RR = 1.0399; 95% CI, 0.8997-1.2019; z = 0.529; <i>P</i> = 0.597). Overweight individuals also did not show a significantly increased risk compared to normal weight (RR = 1.0793; 95% CI, 0.9132-1.2756; z = 0.895; <i>P</i> = 0.371). The risk of developing head protrusion was 1.5 times higher in obese vs. normal-weight (RR = 1.4943; 95% CI, 1.0426-2.1416; z = 2.187; <i>P</i> = 0.029), and 1.4 times higher in overweight vs. normal-weight individuals (RR = 1.3565; 95% CI, 0.9153-2.0103; z = 1.519; <i>P</i> = 0.129). No significant difference in this risk was found between obese and overweight groups (RR = 1.1015; 95% CI, 0.8494-1.4286; z = 0.729; <i>P</i> = 0.466). As for thoracic kyphosis, we determined a 2.1-fold higher risk of occurrence in obese patients compared to normal-weight (RR = 2.1250; 95% CI, 1.2403-3.6408, z = 2.744; <i>P</i> = 0.006) and 2-fold higher in overweight compared to normal-weight (RR = 2.0357; 95% CI, 1.1812-3.5085; z = 2.560; <i>P</i> = 0.011). The study highlights the correlations between dyspnea, musculoskeletal status, and variations by gender and age, suggesting directions for personalized therapeutic interventions.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 5","pages":"487-493"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and cardiovascular diseases: mechanisms, evidence, and mitigation strategies.","authors":"Hari Krismanuel","doi":"10.25122/jml-2025-0018","DOIUrl":"10.25122/jml-2025-0018","url":null,"abstract":"<p><p>One of the most urgent environmental health issues is air pollution, which has a major effect on cardiovascular health. Among other pollutants, fine particulate matter (PM2.5) has been connected to a number of cardiovascular illnesses (CVDs), including myocardial infarction, stroke, and hypertension. The purpose of this review was to summarize current research on the processes by which air pollution raises the risk of CVD and to investigate mitigation and preventative measures. A review of peer-reviewed articles published between 2015 and 2025 was conducted using databases such as PubMed, Web of Science, and Google Scholar. The review focused on studies examining the relationship between PM2.5 and cardiovascular diseases, incorporating epidemiological, experimental, and clinical perspectives. PM2.5 and other pollutants exacerbate CVD risk through mechanisms such as autonomic instability, endothelial dysfunction, oxidative stress, and inflammation. Risks are disproportionately high for vulnerable groups, such as the elderly and those with underlying cardiovascular diseases. Targeted public health policies, stricter air quality regulations, and increased public awareness are essential to mitigate the cardiovascular risks posed by air pollution. Immediate action is imperative to safeguard global health.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 5","pages":"411-427"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical burns: pathophysiology and therapeutic protocols-do cervico-facial injuries pose specific challenges?","authors":"Rares-Adrian Giurgiu, Catalina-Stefania Dumitru, Andreea Grosu-Bularda, Eliza-Maria Bordeanu-Diaconescu, Adrian Frunza, Sabina Grama, Florin-Vlad Hodea, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga","doi":"10.25122/jml-2025-0082","DOIUrl":"10.25122/jml-2025-0082","url":null,"abstract":"<p><p>Chemical burns, though relatively rare, present significant diagnostic and therapeutic challenges due to their complex pathophysiology and the need for specialized care. A retrospective study was conducted, examining the characteristics, treatment, and outcomes of 33 patients with chemical burns admitted to our burn center for 8 years, representing 4.39% of all burn cases. Among them, 15 patients (45.45%) had chemical burns on the face and neck. The majority of these patients were men, with a relatively younger average age, and a significant proportion had work-related accidents. The burned surface area was variable, with many patients sustaining small total body surface area (TBSA), although some presented with extensive involvement. The prevalence of superficial partial-thickness burns was higher, but deep partial-thickness and full-thickness burns were also common. A large proportion of patients had favorable Abbreviated Burn Severity Index (ABSI) scores, indicating a high probability of survival. However, ocular involvement was a major complication. The study emphasizes the importance of timely intervention, including appropriate wound management strategies, specialized dressings, and skin substitutes. The findings also stress the need for a multidisciplinary approach, close monitoring, and adherence to safety protocols to optimize outcomes and minimize long-term complications in patients with chemical burns, particularly those of the face and neck region.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 5","pages":"440-448"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors and relapse in nodal vs. extranodal non-Hodgkin lymphoma of the ENT region: a prospective cohort study.","authors":"Raluca Morar, Norberth-Istvan Varga, Claudia Raluca Balasa Virzob, Nicolae Constantin Balica, Ioana Delia Horhat, Alexandru Chioreanu, Oana Silvana Sarau, Sonia Tanasescu, Razvan Susan, Ion Cristian Mot","doi":"10.25122/jml-2025-0064","DOIUrl":"10.25122/jml-2025-0064","url":null,"abstract":"<p><p>Non-Hodgkin Lymphoma (NHL) arising from the ear, nose, and throat (ENT) region presents unique challenges with regard to diagnosis and treatment. This study investigated the clinical characteristics, prognostic factors, and relapse patterns in patients with NHL originating from lymph nodes (nodal NHL) or other extranodal structures, aiming to identify factors associated with relapse between these two groups. This prospective cohort study included 50 patients diagnosed with NHL in the ENT region at a tertiary hospital in South-Western Romania between 2019 and 2021. Patients were categorized as having nodal or extranodal disease based on histopathological examination and were followed for three years to assess disease evolution, including relapse. Cox proportional hazards regression analysis was employed to identify factors associated with relapse-free survival. Extranodal NHL was associated with a significantly higher prevalence of multiple-site involvement compared to nodal NHL (53.3% vs. 30%, <i>P</i> = 0.021). While a trend towards increased relapse was observed in extranodal NHL, this was not statistically significant (<i>P</i> = 0.125). The presence of disseminated disease (HR = 27.295; <i>P</i> < 0.001) and undergoing only a biopsy (compared to total excision, HR = 4.301; <i>P</i> = 0.027) were identified as independent predictors of relapse. Kaplan-Meier analysis demonstrated significantly different relapse-free survival patterns among groups stratified by NHL localization and dissemination status (<i>P</i> < 0.001). The extent of surgical intervention is a crucial factor influencing relapse risk in ENT NHL, with total excision associated with a lower hazard of relapse. At the same time, extranodal involvement may indicate a more aggressive disease course, particularly when combined with dissemination. However, larger studies with longer follow-ups are needed to validate these findings and refine treatment strategies, especially in regions with limited access to healthcare and screening programs.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"344-350"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive congenital syphilis case report with evidence-based insights into current practices.","authors":"Ramona Mohora, Alexandra Diaconu, Silvia-Maria Stoicescu, Octaviana Cristea","doi":"10.25122/jml-2024-0363","DOIUrl":"10.25122/jml-2024-0363","url":null,"abstract":"<p><p>Congenital syphilis is one of the most well-known congenital infections. Despite notable progress in early diagnosis of syphilis paired with the accessibility of cost-effective treatment and preventive strategies, a few cases continue to be diagnosed in the department of obstetrics. This paper presents a case study of an infant with low birth weight, delivered by an adolescent mother, part of a marginalized demographic group. Due to the mother's lack of routine prenatal care, the infant's management required a series of investigations to establish a comprehensive differential diagnosis. Maternal serological assessments for syphilis, including both non-treponemal antibody test (RPR) and treponemal antibody test (TPHA), yielded positive results following fetal extraction via cesarean section, specifically after diagnosis of syphilis in the infant. Within the first 24 hours of life, newborn serologic tests for syphilis (STS) (including RPR and TPHA assays) exhibited reactivity with titers equivalent to maternal samples. Furthermore, at three weeks of life, the neonatal STS titer exceeded that of the maternal titer, displaying a fourfold increase over the maternal STS level. This finding was concomitant with the detection of IgM antibodies against T. pallidum. Screening for other congenital infections yielded negative results. Subsequent to the high-risk infant follow-up, in accordance with the National Guidelines, the infant had a good outcome.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"324-331"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal cell carcinoma and upper tract urothelial carcinoma in kidney transplant recipients.","authors":"Oana Moldoveanu, Cătălin Baston, Bogdan Sorohan, Lucas Discalicău, Ioanel Sinescu","doi":"10.25122/jml-2025-0065","DOIUrl":"10.25122/jml-2025-0065","url":null,"abstract":"<p><p>Renal cell carcinoma (RCC) is the most common solid-organ malignancy in Western countries, and upper tract urothelial carcinoma (UTUC) is the most common malignancy in Asian countries. The management of RCC/UTUC in kidney transplant recipients is complex and clinically challenging due to post-transplant modifications associated with immunosuppressive treatment. This retrospective study evaluated the incidence, risk factors, treatment outcomes, and oncological implications of RCC and UTUC in kidney transplant recipients from 2008 to 2023. Data were collected from clinical records, and follow-up calls for 20 patients diagnosed with RCC and UTUC among 2,283 kidney transplant recipients, revealing an incidence rate of 0.78% for RCC (18 patients) and 0.087% (two patients) for UTUC. Most patients presented localized disease at diagnosis. Surgical interventions included radical nephrectomy for the native kidney's RCC, radical or partial nephrectomy for allograft RCC, and radical nephroureterectomy for UTUC in the native kidney and allograft. Oncological outcomes indicated a mean follow-up of 51.29 months, during which five patients (25%) developed metastases, which achieved prolonged survival through surgical management, adjuvant therapy, and immunosuppression adjustments. The study highlights the increased cancer risk in this population and underscores the necessity for established screening protocols and individualized treatment strategies to optimize patient outcomes while preserving kidney function. These findings contribute to the ongoing research on managing malignancies in transplant recipients, with implications for further research and clinical guidelines.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"357-363"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand hygiene knowledge, beliefs, and practices among healthcare professionals in the primary healthcare centers in Riyadh, Saudi Arabia: a cross-sectional study.","authors":"Shuaa Rahail Alanazi, Abeer Jassam Alanazi, Mona Salem Alanazi, Fatima Rashid Alenazi, Nessreen Mohammed Algushiry, Ebtisam Awadh Alotaibi, Amerah Ayedh Alenazi, Hind Farhan Alanazi, Mariyyaha Mahdi Alanazi, Hani Rahail Alanazi, Mshari Anwar Alanezi, Latifah Rahail Alanazi","doi":"10.25122/jml-2025-0007","DOIUrl":"10.25122/jml-2025-0007","url":null,"abstract":"<p><p>Hand hygiene (HH) is vital for preventing healthcare-associated infections and ensuring patient safety. This study evaluated the knowledge, beliefs, and practices of healthcare professionals in primary healthcare centers (PHCs) in Riyadh, Saudi Arabia. A cross-sectional descriptive study was conducted using an online validated questionnaire based on the World Health Organization Hand Hygiene Knowledge Questionnaire. Data were analyzed to identify gaps and patterns across professional roles and demographics. A total of 221 healthcare professionals participated, 76% women and 24% men, 57% aged 30-39 years. Most had over 15 years of experience (33%), with nurses comprising the largest professional group. Nearly all participants (91%) had received HH training in the past 3 years, and 88% reported routine use of alcohol-based hand sanitizer. However, only 67% correctly identified the minimum time for alcohol-based sanitizer to kill germs, and misconceptions about hand rubbing efficacy persisted. The primary route of germ transmission was identified as healthcare workers' unclean hands. Most participants agreed that hand rubbing is faster than handwashing and emphasized HH after patient contact, exposure to body fluids, or contact with the patient's surroundings. Nearly all endorsed using both hand rubbing and handwashing for specific scenarios, such as before injections. This study highlights strong HH knowledge and adherence among healthcare workers in Riyadh PHCs, reflecting effective training programs. However, persistent misconceptions and knowledge gaps regarding germ transmission and hand rubbing efficacy require targeted interventions.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"332-337"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of general surgery outcomes in multicenter cohorts in Saudi Arabia.","authors":"Abdulsalam Mohammed Aleid, Nouf Abdullah Alyabis, Fouad Abdulsalam Alghamidi, Reema Hamad Almuneef, Sadeem Khalid Alquraini, Lubna Abdulaziz Alsuraykh, Abdullah Mohammed Al Amer, Hussam Sulaiman AlQifari, Waad Abdullah Alsharari, Nada Fahad Albishri, Hadeel Abdullah Alosaimi, Leen Yahya Algahtany, Loai Saleh Albinsaad, Saud Nayef Salem Aldanyowi","doi":"10.25122/jml-2024-0337","DOIUrl":"10.25122/jml-2024-0337","url":null,"abstract":"<p><p>General surgery outcomes remain a concern despite advancements in techniques, anesthesia, and perioperative care. Achieving consistent, high-quality results and accurately predicting risks remains challenging. This study aimed to identify factors associated with adverse outcomes through a retrospective analysis of general surgery cases across multiple centers in Saudi Arabia. A retrospective cohort study analyzed 14,635 medical records of patients who underwent general surgery across multiple centers in Saudi Arabia from 2010 to 2020. Data from the General Directorate of Health Affairs registry included demographics, comorbidities, procedure details, and outcomes. The study focused on risk factors for 30-day mortality and complications, with subgroup analyses comparing outcomes across facilities. Common surgeries included hernia repair, cholecystectomy, appendectomy, and bowel resection. The overall 30-day mortality rate was 0.74%, and the complication rate was 11.1%. Independent predictors of mortality were ASA grade III/IV, Charlson index ≥3, cardiovascular disease, dementia, renal disease, and longer procedures. Teaching hospitals had lower mortality and complication rates. Complication predictors included older age, ASA III/IV, diabetes, cardiac disease, and high-risk procedures. Evening surgeries were associated with fewer complications. This multicenter study identified patient risk factors and procedure characteristics that predict 30-day outcomes after general surgery. Older age, multiple comorbidities, and high-risk surgeries were linked to poorer outcomes. Teaching centers had better results, emphasizing the role of institutional factors. These findings can guide risk stratification and quality improvement efforts to enhance recovery and provide a foundation for future research to improve surgical practices globally.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"299-305"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rendu-Osler disease, a cause of recurrent epistaxis: a case report.","authors":"Raluca Oana Pulpă, Cătălina Voiosu, Ruxandra Oana Aliuș, Irina Gabriela Ioniță, Andreea Rusescu, Răzvan Hainăroșie, Viorel Zainea","doi":"10.25122/jml-2025-0070","DOIUrl":"10.25122/jml-2025-0070","url":null,"abstract":"<p><p>Rendu-Osler disease is a rare, autosomal dominant vascular malformation disorder with diverse clinical manifestations. It commonly presents with recurrent epistaxis, iron deficiency, and secondary anemia. The condition affects small vessels in the nasal, oral, and gastrointestinal mucosa, the skin of the face, lips, and fingertips, and solid organs. This article discusses general and specific manifestations of the disease, along with its general and particular management. A case presentation is included to demonstrate that treatment must be individualized, taking into account all aspects of the condition, including local and systemic manifestations, comorbidities, and the patient's chronic treatment.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"397-401"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}