Journal of Medicine and Life最新文献

{"title":"A retrospective study on triggering factors and management of epistaxis - our experience in a tertiary ENT clinic.","authors":"Raluca Oana Pulpă, Ruxandra Oana Aliuș, Andreea Rusescu, Irina-Gabriela Ioniță, Răzvan Hainăroșie, Cătălina Voiosu, Viorel Zainea","doi":"10.25122/jml-2025-0107","DOIUrl":"10.25122/jml-2025-0107","url":null,"abstract":"<p><p>Epistaxis is one of the most frequent ENT emergencies, with complex etiologies ranging from local trauma to systemic conditions. This retrospective study analyzed 1,173 patients who presented with epistaxis at a tertiary ENT center over 5 years. Of these, 260 required admissions. The most common triggering factors were hypertension, anticoagulant/antiaggregant therapy, and postoperative complications. A significant portion (38.46%) of cases were idiopathic. Recurrent bleeding was often associated with high blood pressure and male gender, particularly in the 61-70-year age group. Hereditary hemorrhagic telangiectasia was diagnosed in 11 patients, all requiring repeated interventions. Most anterior nasal bleedings had a good response to conservative measures. Posterior or severe cases of epistaxis may require surgical interventions such as cauterization or argon plasma coagulation. The purpose of this paper is to highlight the importance of individualized management, taking into account the location, etiology, and severity. Proper control of cardiovascular comorbidities and careful postoperative monitoring are essential to reducing recurrence and complications associated with epistaxis.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"759-765"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The assessment of untreated surface orthodontic mini-implants' osseointegration through three successive methods.","authors":"Paula Argentina Jiman, Mihaela Felicia Băciuț, Simion Bran, Alexandrina Muntean, Andreea Simona Pop, Cristian Dinu, Lucian Barbu-Tudoran, Alexandru-Flaviu Tăbăran, Romelia Pop, Aranka Ilea, Ondine Patricia Lucaciu, Meda Romana Simu, Sebastian Candrea, Ioana Porumb, Grigore Băciuț","doi":"10.25122/jml-2025-0022","DOIUrl":"10.25122/jml-2025-0022","url":null,"abstract":"<p><p>Mini-implants (MIs) with untreated surfaces are conventionally retained solely through mechanical forces, without any secondary retention mechanism involved (osseointegration). A previously reported issue is the fracture of untreated surface MIs during removal, after orthodontic treatment. Several factors, including potential osseointegration, may cause these fractures. The current research investigates the possibility of osseointegration of untreated surface MIs using three consecutive techniques: removal torque (Tq) measurement using a customized device, immediately followed by spectroscopy analyses (EDX/EDS-Energy Dispersive X-ray Spectrometry and Scanning electron microscopy-SEM), as well as several histological methods to detect the presence of newly-formed bone-cells, which were seen as an indicator for osseointegration. This observational study involved the analysis of removed untreated surface MIs from patients (with a mean age of 21.58 years and a median value of 17 years) at the end of the MI treatment phase. While the EDS, SEM technique, and analysis of removal Tq suggested the presence of osseointegration on the surface of the MIs, the histological methods disproved these results.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"772-780"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of hearing function and prevalence of hearing impairment among stroke patients and its relationship to leisure and social activity limitation: a nationwide population-based study.","authors":"Amal Mohammed Sunyur, Mohamed Abdel-Haleem, Abdulaziz Khalid Alawfi, Ahmad Badawi, Layan Abdulaziz Alharbi, Hussam Abduljabbar Alahmadi, Sulaiman Abdullah, Zakaria Yahya Khawaji","doi":"10.25122/jml-2025-0019","DOIUrl":"10.25122/jml-2025-0019","url":null,"abstract":"<p><p>Stroke, which is a leading cause of disability, is presumed to affect hearing by impacting the auditory pathways or hearing organs, influencing communication and socialization. We analyzed data from the National Health Interview Survey (NHIS) from 2015-2018, including 118,625 individuals. Hearing function and activity limitations were evaluated by self-reported measures. Various statistical tests and regression analyses were used to compare and investigate the data between the different groups. Stroke patients had a higher prevalence of hearing dysfunction, with 23.8% reporting excellent hearing versus 46.9% among non-stroke individuals (<i>P</i> < 0.001). Additionally, stroke patients exhibited higher rates of little trouble hearing (19.9% vs. 10.9%), moderate trouble hearing (10.5% vs. 4.2%), much trouble hearing (8.7% vs. 2.2%), and deafness (0.8% vs. 0.3%) when compared to non-stroke subjects (<i>P</i> < 0.001 for all). Several factors were identified as significant contributors to hearing impairment among stroke patients, including male gender (OR = 1.58; 95% CI, 1.39-1.8; <i>P</i> < 0.001), diabetes (OR = 1.2; 95% CI, 1.04-1.38; <i>P</i> = 0.01), smoking (OR = 1.44; 95% CI, 1.2-1.73; <i>P</i> < 0.001), and sinusitis (OR = 1.45; 95% CI, 1.23-1.7; <i>P</i> <0.001). Stroke among subjects with hearing impairment was strongly related to limitation in leisure and social activities (OR = 2.5; 95% CI, 2.30-2.84). Our study demonstrates significantly higher rates of hearing impairment among stroke patients compared to non-stroke individuals, which adversely impacts their participation in leisure and social activities.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"785-793"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenges of autism spectrum disorder in women without intellectual or language impairments: a narrative review.","authors":"Alexandra Dolfi, Cătălina Tudose","doi":"10.25122/jml-2025-0118","DOIUrl":"10.25122/jml-2025-0118","url":null,"abstract":"<p><p>Autism Spectrum Disorder (ASD) in adult women without intellectual or language impairments is frequently under-recognized, due to subtler manifestations, greater use of compensatory social strategies, and reliance on diagnostic frameworks developed from male presentations. Diagnostic overshadowing, where autistic traits are misattributed to other psychiatric conditions, further delays accurate identification. This narrative review aims to critically evaluate recent evidence on the diagnostic challenges of ASD in adult women without intellectual or language impairments, assess the performance of widely used screening tools, and present recommendations for improving gender-sensitive diagnostic practices. A structured literature search was applied (PubMed, PsycINFO, Scopus; January 2010-July 2025; English language) targeting studies on females aged ≥18 years without intellectual or language impairment. Diagnostic accuracy, screening tools, camouflaging, misdiagnosis, and psychosocial outcomes were examined. Original research, meta-analyses, and systematic reviews were included, and a narrative synthesis approach was chosen due to study heterogeneity. Female-typical presentations often include subtle social-communication differences, context-specific restricted interests, and higher camouflage levels than males, which decrease the sensitivity of standard screening tools. Women are more likely to receive prior psychiatric diagnoses before ASD is recognized, contributing to mental health burdens and poorer functional outcomes. Current adult ASD screening tools have limited capacity to detect female phenotypes. Integrating camouflaging assessment, nuanced developmental histories, and updated, gender-inclusive screening instruments is essential to improving diagnostic equity.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"710-720"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive monitoring solutions in the second trimester of pregnancy.","authors":"Madalina Piron-Dumitrascu, Dragos Cretoiu, Valentin Nicolae Varlas, Nicolae Suciu","doi":"10.25122/jml-2025-0106","DOIUrl":"10.25122/jml-2025-0106","url":null,"abstract":"<p><p>Simple, non-invasive, and affordable ambulatory fetal monitoring methods have been integrated into routine prenatal care, with the potential to enhance maternal-fetal health surveillance. Although conventional prenatal care is the basis of pregnancy monitoring, more and more studies are presenting complementary approaches that aim to identify early, potentially pathological changes in fetal status. The use of portable devices, such as a handheld fetal Doppler (for at-home detection of fetal heartbeats) and a pulse oximeter (for maternal heart rate assessment), has been proposed as additional tools in the context of pregnancy monitoring. These devices may influence patients' behavior regarding seeking medical care and using health services. Access to instruments that allow minimal monitoring at home for pregnant women could facilitate the earlier identification of possible changes, especially in situations where access to direct medical consultations is delayed or restricted. The ease of use and availability of these devices in the broader market raise the question of their integration into a standardized prenatal monitoring framework. This study investigated the feasibility and patients' perceptions of using handheld Dopplers during pregnancy. An observational analytical study was conducted between January 2019 and December 2023 at the Polizu Clinical Hospital in Bucharest, involving 1,127 pregnant women who met the inclusion criteria (gestational age between 14 and 27 weeks + 6 days and absence of major psychiatric disorders). Of these, 101 women completed a questionnaire regarding fetal monitoring in the second trimester. Responses were analyzed with a focus on the perceived usefulness of the handheld Doppler at home. The majority of participants (79.2%) considered the device helpful, 76.2% reported that it provided them with peace of mind, and 22.8% noted that it led to greater involvement from their partner or family. These findings demonstrate the good acceptability of the tested device, especially among pregnant women in their first pregnancy or with a perceived increased risk, and support the opportunity to integrate this type of monitoring into current obstetric practice. Furthermore, ambulatory and home fetal monitoring solutions provide valuable support in the management of modern pregnancies, but they cannot replace clinical assessment and specialist supervision.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"811-815"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ki-67 correlations in breast cancer.","authors":"Ruxandra Vatavu, Ana Maria Dumitrescu, Cristinel Ionel Stan, Ana Maria Haliciu, Anca Sava","doi":"10.25122/jml-2025-0119","DOIUrl":"10.25122/jml-2025-0119","url":null,"abstract":"<p><p>Brain metastases from breast cancer represent a serious complication, associated with reduced survival and impaired quality of life. Increased patient survival and the limited ability of the blood-brain barrier to be crossed by systemic therapies have led to a rising incidence of these lesions. The molecular profile of metastases may differ from that of the primary tumor in approximately 29% of cases, significantly influencing the choice of targeted treatment. In this retrospective study, we included 100 women who underwent craniotomy for breast cancer brain metastases between 2015 and 2020 at the Prof. Dr. Nicolae Oblu Neurosurgery Clinic, Iași. We recorded demographics (age, residence), latency from primary diagnosis to brain metastasis, and MRI features (number, location, edema, hemorrhage). Histopathology and immunohistochemistry included GATA3, CK5/6, ER, PR, HER2, and Ki-67 using standardized protocols. ER/PR positivity was defined as ≥1% nuclear staining; HER2 was scored 0-3+ per ASCO/CAP; Ki-67 was reported as a percentage index. The most frequent metastatic subtypes were HER2-positive (32%) and triple-negative (25%). The mean Ki-67 index was 48.2% and showed a significant inverse correlation with the time from primary breast cancer diagnosis to brain metastasis (r = -0.57; P < 0.001). Higher Ki-67 values were associated with hemorrhagic lesions, while lower values occurred in solitary metastases. Patients receiving hormonal therapy had longer median survival (29.5 months) compared to those receiving targeted therapy (11.9 months; P < 0.001). Immunohistochemical profiling of brain metastases from breast cancer, focusing on ER, PR, HER2, and Ki-67, revealed specific correlations between tumor proliferation, time to metastasis, and neuroimaging features such as hemorrhage and lesion location. HER2-positive and triple-negative subtypes showed higher brain metastatic potential and poorer outcomes with targeted therapy, while luminal tumors responded better to hormonal treatment. The inverse correlation between Ki-67 and metastasis latency, as well as its association with aggressive imaging phenotypes, represents an original contribution of this study, underscoring the need for tailored therapeutic strategies based on combined pathological and imaging data.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 8","pages":"753-758"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core decompression with autologous adult live-cultured osteoblast implantation for osteonecrosis of the femoral head: a prospective mid-term outcome analysis.","authors":"Alok Chandra Agrawal, Ankit Kumar Garg, Shubham Bhardwaj, Harshal Sakale, Anupam Inamdar, Lohitesh Saparey, Rudra Narayan Dash","doi":"10.25122/jml-2024-0392","DOIUrl":"10.25122/jml-2024-0392","url":null,"abstract":"<p><p>Osteonecrosis of the femoral head (ONFH) is a challenging condition that mainly affects young and middle-aged adults, causing pain, disability, and joint collapse. Current treatment options include medications, physical therapy, and surgical interventions such as core decompression and total hip replacement. However, there is growing interest in regenerative medicine for managing ONFH. This study evaluated the outcomes of core decompression augmented with adult autologous live cultured osteoblasts (AALCO) in patients with early-stage ONFH. Patients diagnosed with ONFH, Ficat-Arlet Grades 1, 2, and 3, underwent a staged procedure involving bone marrow aspiration and the cultivation of 48 million osteoblastic lineage cells. Subsequently, this culture was injected following core decompression and curettage of the necrotic area in the femoral heads. Patients were then followed for 18 to 26 months and evaluated for radiological progression of the disease and changes in functional outcome using the Harris Hip Score (HHS) and Visual Analog Scale (VAS). Forty-eight hips (34 patients with 14 bilateral ONFH) were included in the study and followed up for 18 to 26 months. During this period, 29 patients (40 hips) exhibited progressive signs of healing, resulting in a significant improvement in the mean HHS and a reduction in VAS scores. Core decompression augmented with implantation of autologous live cultured osteoblasts is a reliable treatment approach for managing the early stages of ONFH in young patients caused by various factors. The method aims to halt disease progression through osteoblastic stem cell-mediated new bone formation, leading to improved functional outcomes and potentially delaying or avoiding the need for total hip arthroplasty.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"648-655"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world characteristics of systemic mastocytosis in Romania: insights from a reference-center-based descriptive study.","authors":"Delia Soare, Dan Soare, Brîndușa Petruțescu, Oana Firescu, Poliana Leru, Corina Silvia Pop, Lucian Negreanu, Vlad Voiculescu, Horia Bumbea","doi":"10.25122/jml-2025-0103","DOIUrl":"10.25122/jml-2025-0103","url":null,"abstract":"<p><p>Systemic mastocytosis (SM) is a rare clonal mast cell disease characterized by heterogeneous clinical presentations and molecular features that vary across different regions; however, data from Central-Eastern Europe remain limited. This study aimed to describe the demographic, clinical, laboratory, and molecular characteristics of Romanian adults diagnosed with SM and followed at the national reference center for mast cell disorders in Bucharest, while also exploring real-world management patterns and outcomes. We conducted a retrospective observational study including 162 adult patients evaluated between January 2006 and March 2025 who met the 2022 World Health Organization criteria for SM. Data extracted from electronic medical records included WHO subtype, <i>KIT</i> mutation status, serum tryptase levels, organ involvement, treatment history, and survival outcomes. A descriptive statistical approach was used, with continuous variables expressed as medians and interquartile ranges, and categorical variables as counts and percentages. A subset of eight patients underwent bone marrow flow cytometry immunophenotyping to assess the diagnostic contribution of CD2 and CD25. Among the entire cohort, indolent SM was the most frequent form (53.1%), followed by cutaneous mastocytosis (17.3%), smoldering SM (5.6%), aggressive SM (3.7%), and SM with associated hematologic neoplasm (8%). The <i>KIT</i> D816V mutation was detected in 43% of tested individuals, and the median baseline serum tryptase was 20.55 μg/L. Common organ-related findings included osteoporosis (17.9%), osteopenia (21.7%), cutaneous lesions (29%), and hepatomegaly (4%). First-line symptomatic therapy (H₁/H₂ antihistamines ± montelukast) was administered to 77% of patients, while four patients with advanced disease received midostaurin treatment. Immunophenotyping confirmed aberrant expression of CD2 and CD25 in all eight analyzed cases. This first national series from Romania underscores the predominance of indolent SM and the clinical burden of organ involvement, reinforcing the need for early diagnosis and personalized, risk-adapted therapeutic approaches.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"640-647"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis, stem cells, and obesity: metabolic exploration for therapeutics.","authors":"Carolina Constantin, Elena-Georgiana Dobre, Adriana Narcisa Munteanu, Mihaela Surcel, Constantin Căruntu, Sabina Andrada Zurac, Monica Neagu","doi":"10.25122/jml-2025-0033","DOIUrl":"10.25122/jml-2025-0033","url":null,"abstract":"<p><p>Psoriasis is a chronic inflammatory cutaneous disease with a complex pathogenesis that remains incompletely understood. New data suggest that psoriasis severity may be more accurately assessed by examining inflammation, oxidative stress, and hormones, although further research is needed to substantiate the clinical value of these biomarkers. The multifactorial causes of psoriasis encompass metabolic deregulations, such as lipid alterations that favor inflammation, exacerbate immune cell activity, and worsen the disease symptomatology. The pathophysiological link between psoriasis and obesity may be revealed through a crosstalk between adipocytes and the immune system, mediated by diverse soluble mediators, including adipokines. In this autoimmune disease, dermal mesenchymal stem cells (MSCs) are potential cellular players that connect autoimmune mechanisms, inflammation, and dysregulation of lipid metabolism. Networks of soluble factors, immune and non-immune cells, and MSCs mediate the inflammatory state in psoriasis. In many recent studies, the relapse has been associated with the potential role of MSCs in this process, endorsing MSCs as a new therapeutic reservoir in psoriasis. Thus, in our review, we aimed to evaluate the potential connection between autoimmunity, inflammation, and dermal mesenchymal stem cells, along with dysregulation of lipid metabolism, to elucidate the identity of psoriasis and identify potential new diagnostic and/or therapeutic targets.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"608-620"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer screening in Europe and Romania: a review of policies, progress, and persistent disparities.","authors":"Gabriel Marian Saveliev, Valentin Nicolae Varlas, Madalina Piron-Dumitrascu, Nicolae Suciu","doi":"10.25122/jml-2025-0099","DOIUrl":"10.25122/jml-2025-0099","url":null,"abstract":"<p><p>Cervical cancer remains one of the leading causes of cancer-related death among women globally, despite being largely preventable through human papillomavirus (HPV) vaccination and regular screening. While many European countries have made significant progress in reducing incidence and mortality, Romania continues to report the highest rates within the European Union. This narrative review synthesized data from PubMed, Web of Science, Embase, and Google Scholar to evaluate cervical cancer screening policies across Europe, with a particular focus on Romania. The review included studies on HPV vaccination, cytology- and HPV-based screening, national program implementation, and public health strategies. Countries with organized, population-based screening programs and high HPV vaccine coverage, such as the Netherlands, Finland, and the UK, demonstrate lower incidence and mortality. In contrast, Romania faces persistent systemic barriers: limited public awareness, insufficient infrastructure, low screening participation (<20%), and suboptimal HPV vaccine uptake. Efforts to align national policies with WHO and EU cancer control strategies remain fragmented. Romania illustrates the deep disparities in cervical cancer prevention within Europe. Strategic reforms, including transitioning to HPV-based screening, expanding access to vaccination, enabling self-sampling, and enhancing public education, are critical. Integration into broader EU frameworks such as Europe's Beating Cancer Plan may accelerate progress. While the tools for cervical cancer prevention are well established, Romania's case underscores the need for systemic, context-specific interventions to reduce disease burden and promote equity across Europe.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"604-607"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}