Journal of Medicine and Life最新文献

{"title":"Experimental study on the compressive strength of fixed prosthetic restorations on tooth preparations with or without horizontal preparation.","authors":"Lucia Alexandra Drăghici, Raluca Monica Comăneanu, Diana Vrânceanu, Florin Baciu, Mirel Stoian-Albulescu, Anca Monica Dobrescu, Tudor Petru Ionescu, Cherana Gioga","doi":"10.25122/jml-2025-0124","DOIUrl":"10.25122/jml-2025-0124","url":null,"abstract":"<p><p>Fixed prosthetic restorations, particularly those made entirely of zirconia, are widely used in clinical dental practice for the restoration of natural teeth. Their success largely depends on the design of the tooth preparation, especially the type of finish line, as well as the restoration's ability to withstand occlusal forces during mastication. Over 12 months, a total of 21 extracted teeth were initially collected, from which six were selected for this study. To achieve the objective of the study, three teeth were prepared with a horizontal finish line (shoulder), and the remaining three were prepared without a defined finish line (vertical preparation). For each prepared tooth, three full-contour zirconia crowns were fabricated. To ensure accurate comparison and standardization of occlusal force application during mechanical testing, all crowns were designed with identical morphology. The force application device used in mechanical testing was digitally designed to replicate the anatomy of the antagonistic teeth corresponding to each tested crown. Samples I and III showed significant structural changes, including horizontal fractures at the cervical level. Samples II, 1, and 2 exhibited no visible damage. The maximum recorded compressive forces at which structural failure occurred varied widely, ranging between 180 N and 2537 N. Consequently, all samples that recorded fracture values below 1000 N were analyzed separately for interpretation. The findings of this experimental study indicate that tooth preparation design significantly influences the compressive strength of monolithic zirconia crowns. Both preparation types-shouldered and shoulderless-demonstrated high resistance values, with a slight advantage observed in favor of the preparations with a defined finish line (shoulder).</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"671-677"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shock Index as an indicator for blood transfusion or surgical intervention among multiple trauma patients in Jordan.","authors":"Liqaa Raffee, Khaled Alawneh, Wasfi Al-Salaita, Nour Negresh, Ahmad Al-Omari, Hassan Alawneh, Abeer Khafajah, Majd Elzghairin, Zaid Tashtoush, Yamen Alawneh, Rana Haddad","doi":"10.25122/jml-2024-0348","DOIUrl":"10.25122/jml-2024-0348","url":null,"abstract":"<p><p>Trauma remains a leading cause of mortality worldwide, with uncontrollable bleeding contributing significantly to preventable deaths. This study assessed the utility of the shock index (SI) in predicting clinical outcomes in trauma patients. A retrospective analysis was conducted on 122 trauma patients admitted to King Abdullah University Hospital, Jordan. Patients were categorized into two groups based on their SI: normal (SI < 0.9) and elevated (SI> 0.9). Clinical outcomes, including the need for interventions, blood transfusions, and neurological status, were compared between the groups. Patients with elevated SI had worse neurological outcomes (17% vs. 1.1%, <i>P</i> < 0.001), higher rates of airway interventions (23% vs. 4.3%, <i>P</i> = 0.005), increased incidence of pneumothorax/hemothorax (<i>P</i> = 0.005), and a greater need for blood transfusions (10% vs. 1.1%, <i>P</i> = 0.046). Elevated SI was associated with overall hemodynamic instability and worse clinical outcomes, supporting its use as a rapid assessment tool in trauma care. Elevated SI was strongly associated with worse clinical outcomes in trauma patients, including increased need for interventions and higher complication rates. SI proves to be a simple yet effective tool for the rapid assessment of trauma severity, while holding the potential to improve early triage and decision-making within emergency care settings.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"633-639"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk HPV infection and the risk of preterm birth in a Romanian tertiary maternity cohort: a prospective observational study.","authors":"Carmen Elena Condrat, Dragos Cretoiu, Simona Raluca Iacoban, Silviu Cristian Voinea, Nicolae Suciu","doi":"10.25122/jml-2025-0102","DOIUrl":"10.25122/jml-2025-0102","url":null,"abstract":"<p><p>Preterm birth (PTB; < 37 weeks) affects ²10 % of pregnancies and is the leading cause of neonatal mortality. Whether maternal high-risk human papillomavirus (hr-HPV) infection contributes to spontaneous PTB is unsettled. Romania, with Europe's highest cervical-cancer burden, offers a relevant setting to explore this association. We prospectively followed 151 women enrolled before 14 weeks' gestation at a tertiary maternity hospital (January 2021-May 2022). Cervical samples were tested with the Cepheid Xpert HPV assay, which detects 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68). Maternal age, parity, smoking, body mass index, and comorbidities were recorded. PTB was defined as delivery < 37 weeks (very PTB < 34 weeks). Multivariable logistic regression estimated adjusted odds ratios (aOR) for PTB associated with hr-HPV, and Kaplan-Meier curves compared time-to-delivery between infected and uninfected pregnancies. hr-HPV DNA was detected in 60/151 pregnancies (39.7 %). PTB occurred in 28.3 % of hr-HPV-positive versus 13.2 % of hr-HPV-negative women (<i>P</i> = 0.02); very PTB rates were 8.3 % and 2.2 %, respectively. Median gestational age and birth weight were lower among infected mothers (38.0 weeks vs 39.0 weeks, <i>P</i> = 0.04; 3025 g vs 3230 g, <i>P</i> = 0.03), while Apgar scores were comparable. After adjustment for maternal covariates, hr-HPV remained independently associated with PTB (aOR = 2.38; 95% CI 1.07-5.29; <i>P</i> = 0.033), and survival analysis confirmed a higher cumulative hazard of early delivery (log-rank <i>P</i> = 0.021). First-trimester hr-HPV carriage approximately doubled the odds of preterm birth in this Romanian cohort, independent of established risk factors. Although genotype-specific risks require confirmation, the data align with emerging evidence that HPV infection itself-not only post-treatment cervical changes-may promote spontaneous PTB. If corroborated, these findings extend the public-health value of HPV vaccination beyond cancer prevention and support closer obstetric surveillance of hr-HPV-positive pregnancies.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"685-692"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The preparation and inception of a National Electronic Register for Cardiovascular Rehabilitation (NERCVR) with initial results, as part of a National Electronic Register for Cardiovascular Diseases (NERCVD).","authors":"Mihaela Mandu, Gelu Onose, Catalina Liliana Andrei, Andreea Elena Lacraru, Ioana Andone, Aura Spinu, Cristina Popescu, Dragos-Alin Trache, Alexandru Ion, Iulian Nastasa, Liliana Florina Andronache, Dumitru Cristinel Badiu, Stefan Sebastian Busnatu","doi":"10.25122/jml-2025-0112","DOIUrl":"10.25122/jml-2025-0112","url":null,"abstract":"<p><p>A review of the literature and current practice shows that Romania lacks both a National Electronic Register for Cardiovascular Diseases (NERCVD) and a dedicated National Electronic Register for Cardiovascular Rehabilitation (NERCVR). Such registers are increasingly essential in the digital era, particularly within the European Union, where several member states (e.g., Sweden, Germany, the Netherlands) already operate national cardiovascular registries. To identify a feasible IT architecture for a Romanian registry, we assessed available platforms and selected the Research Electronic Data Capture (REDCap) web platform as the most suitable, based on its functionality, infrastructure requirements, and flexibility. Using REDCap, we designed the project \"Cardiovascular Rehabilitation and Secondary Prevention\" and configured a proof-of-concept NERCVR. We managed to configure, taking into account previous experiences in the field presented in the discussions, a demonstrative model - proof of concept type - of the National Electronic Register for Cardiovascular Rehabilitation, with other types of data categories and related digital components to be created in the future, thus concluding the final form of a National Electronic Register for Cardiovascular Diseases.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"656-670"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic marginal zone lymphoma associated with chronic inflammatory demyelinating polyradiculoneuropathy: a case report.","authors":"Tarek Mohammed, Halimah Saleh, Huda Albraim, Sariya Khan, Sahar Albraim, Deema Bakhashab","doi":"10.25122/jml-2025-0023","DOIUrl":"10.25122/jml-2025-0023","url":null,"abstract":"<p><p>Chronic inflammatory demyelinating polyradiculopathy (CIDP) is an acquired immune-mediated neuropathy characterized by progressive or relapsing-remitting proximal and distal weakness. Lymphomas are among various hematological malignancies associated with CIDP. Splenic marginal zone lymphoma (SMZL) is a rare, indolent B-cell non-Hodgkin lymphoma that classically presents with splenomegaly and cytopenia. The co-occurrence of SMZL and CIDP is extremely rare; the diagnosis thus presents a unique challenge both diagnostically and therapeutically. We report a 65-year-old male patient with progressive proximal weakness, night sweats, and splenomegaly. Investigations revealed pancytopenia with imaging studies confirming the splenomegaly. Further investigations, such as a bone marrow biopsy and histopathology of the spleen, were indicative of a hypocellular marrow and SMZL, respectively. Simultaneously, a diagnosis of CIDP was established based on clinical findings, as well as electromyography and nerve conduction studies. For CIDP, immunosuppressive therapy was initiated; however, no treatment was administered for SMZL due to its indolent nature. He showed partial neurological improvement with the treatment given for CIDP. This underlines the importance of treating both diseases. The rare association of CIDP and SMZL is presented in this case, highlighting the importance of a comprehensive diagnostic workup in patients with neurological and hematological abnormalities. Therefore, for the management of such patients, timely identification and appropriate therapeutic approaches will be necessary for an improved outcome.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"693-697"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' knowledge and awareness of physiological genu varum in Saudi Arabia.","authors":"Omer Alrasheed, Amnah Alkhawajah, Rabab Alkhalaf, Ziyad Saad Alasmari, Mazen Mohammed Hakami, Mohammed Almarhabi","doi":"10.25122/jml-2024-0404","DOIUrl":"10.25122/jml-2024-0404","url":null,"abstract":"<p><p>Genu varum is one of the most common lower limb musculoskeletal variations observed in Saudi Arabia. Understanding parents' knowledge and perceptions of genu varum is essential for identifying gaps in awareness and improving early recognition and management through targeted educational interventions. This study aimed to assess the level of parental knowledge and awareness regarding physiological genu varum in Saudi Arabia. A questionnaire-based cross-sectional study was conducted among Saudi parents aged 18 years or older. Data were collected electronically via Google Forms, ensuring anonymity. The questionnaire, disseminated through various social media platforms, consisted of three sections: demographic information, general knowledge of genu varum, and awareness of physiological genu varum. A total of 1,222 respondents participated, with the majority being female (70.2%). Overall, 52.2% of parents demonstrated poor knowledge, while 47.8% had good knowledge of the condition. Parental knowledge was significantly associated with region, marital status, and having a child diagnosed with genu varum. In contrast, gender, age, income level, and nationality showed no significant influence. The current study revealed that approximately half of the surveyed parents demonstrated adequate knowledge about genu varum, particularly its physiological form and potential consequences. Higher knowledge was associated with being married and having a child with genu varum.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"678-684"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative stroke in CABG: a ten-year study of stroke incidence and contributing risk factors in Jordan.","authors":"Emad Hijazi, Nabil Al-Zoubi, Qusai Aljarrah","doi":"10.25122/jml-2024-0326","DOIUrl":"10.25122/jml-2024-0326","url":null,"abstract":"<p><p>Stroke is a serious complication that occurs in approximately 3% of patients undergoing elective coronary artery bypass grafting (CABG). Neurologic dysfunction is a well-researched challenge in cardiac surgery, particularly when cardiopulmonary bypass is used. This study aimed to determine the stroke rate following CABG in a Jordanian population, based on our experience at a low-volume cardiac center. We conducted an observational descriptive study involving 446 patients who underwent CABG between January 2011 and December 2021. Stroke occurred in five patients (1.12%). Among 208 female patients, four developed stroke (1.9%), three of whom had diabetes mellitus (75%), and two had a prior history of transient ischemic attacks (TIAs). In contrast, only one out of 238 male patients experienced a stroke (0.4%); this patient had diabetes but had no history of TIA. The incidence of stroke in female patients was four times higher than in men. These findings suggest that improving surgical techniques, particularly in low-resource or developing settings, may contribute to reducing the risk of postoperative stroke. Strategies such as minimizing aortic manipulation during CABG while utilizing cardiopulmonary bypass could be beneficial, especially in patients with known risk factors for cerebrovascular events.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"621-625"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of gender on clinical characteristics in patients with atrial fibrillation and STEMI.","authors":"Dan Pasaroiu, Imre Benedek, Andra Chirtes, Violeta Masca, Renata Gerculy, Monica Chitu, Theodora Benedek","doi":"10.25122/jml-2025-0041","DOIUrl":"10.25122/jml-2025-0041","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease remains one of the leading causes of morbidity and mortality worldwide, accounting for approximately 3.9 million deaths annually due to its complications. This single-center, retrospective cohort study included 109 patients who underwent coronary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) between April and July 2022 at the Cardiology Clinic of the County Emergency Clinical Hospital in Targu Mureș, Romania. Women diagnosed with STEMI were found to be older at the time of presentation compared to men, with this difference reaching statistical significance (<i>P</i> = 0.0148). The incidence of atrial fibrillation was higher in women, with a statistically significant difference (<i>P</i> = 0.0258). Stratification of patients based on the location of culprit lesions did not reveal a statistically significant difference in the occurrence of atrial fibrillation. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in women than in men (<i>P</i> = 0.0200). The multivariate analysis revealed that the occurrence of atrial fibrillation was dependent on age (<i>P</i> = 0.0025), smoking (<i>P</i> < 0.0001), and cholesterol levels (<i>P</i> = 0.0182), but independent of sex (<i>P</i> = 0.2094), ejection fraction (<i>P</i> = 0.2293), the presence of hypertension (<i>P</i> = 0.1142), chronic kidney disease (<i>P</i> = 0.6935), diabetes mellitus (<i>P</i> = 0.9375), triglyceride levels (<i>P</i> = 0.7614), high-sensitivity cardiac troponin I (hs-cTnI, <i>P</i> = 0.4422), and creatine kinase (CK, <i>P</i> = 0.7420). In summary, women with STEMI presented at an older age, had higher NT-proBNP levels, experienced more frequent atrial fibrillation, and had a greater likelihood of circumflex artery involvement. Smoking and age were the only factors significantly associated with atrial fibrillation in the multivariable analysis.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 7","pages":"626-632"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From guidelines to clinical practice: the impact of sentinel lymph node mapping on surgical management in endometrial cancer.","authors":"Alexandru Blidaru, Maria-Bianca Anca-Stanciu, Andrei Manu, Bogdan Cătălin Coroleucă, Ciprian Andrei Coroleucă, Elvira Brătilă","doi":"10.25122/jml-2025-0089","DOIUrl":"10.25122/jml-2025-0089","url":null,"abstract":"<p><p>Sentinel lymph node (SLN) mapping using indocyanine green (ICG) fluorescence has emerged as a less invasive alternative to systematic lymphadenectomy in the surgical management of early-stage endometrial cancer. This study aimed to evaluate the feasibility, accuracy, and clinical outcomes of SLN mapping integrated into laparoscopic staging for endometrial cancer based on our institutional experience. A retrospective study was conducted on 29 patients with early-stage endometrial cancer who underwent laparoscopic hysterectomy with bilateral salpingo-oophorectomy and SLN mapping using ICG. Detection rates, histopathological findings, complication rates, and follow-up outcomes were recorded. SLN detection was successful in 100% of patients, with bilateral mapping achieved in 75.9% of cases. Metastatic involvement was found in 13.8% of cases, with micrometastases detected through ultrastaging. No significant intraoperative or postoperative complications were reported. Risk-adapted adjuvant treatment was administered according to ESGO/ESTRO/ESP guidelines. After a median follow-up of 18 months, 93.1% of patients remained disease-free. SLN mapping with ICG is a reliable and safe technique for lymphatic staging in endometrial cancer, enabling accurate nodal assessment while minimizing surgical morbidity. These findings support the routine implementation of this approach in the laparoscopic management of early-stage disease.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"575-579"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritizing the risk of cervical cancer: findings from the SCCUT Multicentre Initiative.","authors":"Gabriel Marian Saveliev, Valentin Nicolae Varlas, Madalina Piron-Dumitrascu, Nicolae Suciu","doi":"10.25122/jml-2025-0100","DOIUrl":"10.25122/jml-2025-0100","url":null,"abstract":"<p><p>Cervical cancer (CC) remains a significant global health burden, ranking eighth in incidence and ninth in cancer-related mortality among women worldwide. Persistent infection with high-risk human papillomavirus (HPVhr) is the primary etiological factor in CC development. The SCCUT program in Romania was designed to enhance access to primary screening and assess HPVhr prevalence among women aged 25-65 years in the South-Muntenia region. Between August 2022 and November 2023, a total of 36,813 women were enrolled in the SCCUT program after providing informed consent. Based on age, participants underwent either a Pap test and/or HPVhr testing. Clinical and demographic data-including age, hormonal status, intrauterine device (IUD) use, presence of leucorrhea, and history of cervical interventions-were collected via structured questionnaires. HPVhr testing was performed using the AmpFire^® HPV Screening system and processed in the lead partner laboratory. Of the total cohort, 12.5% (<i>n</i> = 4,588) tested positive for HPVhr. HPVhr positivity was significantly associated with younger age (mean 45.12 ± 9.21 years vs. 46.28 ± 8.56 years; <i>P</i> < 0.001) and cyclic hormonal status (<i>P</i> < 0.001). No statistically significant associations were found between HPVhr status and IUD use, presence of leucorrhea, or prior cervical interventions (biopsies or cauterizations). The SCCUT program confirms the critical role of HPVhr in cervical carcinogenesis and supports its use as a first-line screening tool. These findings highlight the importance of implementing widespread primary HPVhr testing, particularly in underserved populations. Increasing public awareness, improving HPV vaccination rates, and expanding access to early detection programs remain essential for effective cervical cancer prevention in Romania and globally.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"590-593"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}