Journal of Medicine and Life最新文献_第4页

Cost-effectiveness of Cerebrolysin as an add-on treatment for neurorecovery after traumatic brain injury. 脑溶素作为外伤性脑损伤后神经恢复附加治疗的成本-效果。

Journal of Medicine and Life Pub Date : 2025-04-01 DOI: 10.25122/jml-2025-0087

Stefan Strilciuc, Diana Alecsandra Grad, Cristian Vlădescu, Anca Dana Buzoianu, Carmen Albu, Dafin Fior Mureșanu

{"title":"Cost-effectiveness of Cerebrolysin as an add-on treatment for neurorecovery after traumatic brain injury.","authors":"Stefan Strilciuc, Diana Alecsandra Grad, Cristian Vlădescu, Anca Dana Buzoianu, Carmen Albu, Dafin Fior Mureșanu","doi":"10.25122/jml-2025-0087","DOIUrl":"10.25122/jml-2025-0087","url":null,"abstract":"Traumatic brain injuries (TBIs) are a leading cause of death and long-term disability worldwide, with incidence and injury mechanisms varying by age group and region. Impairment of functional status, diagnoses of anxiety and depression are encountered post-TBI. Studies have shown that Cerebrolysin can have positive effects among TBI survivors. We conducted a cost-effectiveness analysis (CEA) among patients with moderate TBI, using data from the CAPTAIN II trial. This exercise was carried out on a three-month timeline from the provider's perspective. Two models were incorporated in the CEA: control (placebo group) and treatment (Cerebrolysin group). Our analysis showed that Cerebrolysin had a high probability of being cost-effective, based on Glasgow Outcome Scale Extended (GOSE) (in over 80% of patients with moderate TBI), Hospital Anxiety and Depression Scale (HADS) Depression and Anxiety scores (for the former two, in over 95% of patients with moderate TBI), when assuming a lasting effect (12 months) of the CAPTAIN trial intervention protocol. A model-based approach is needed to account for potential sources of bias beyond the 90-day observation period of this clinical trial. Furthermore, economic evaluations incorporating patients diagnosed with all TBI severities are needed.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"387-392"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeat robotic nephron-sparing surgery for metachronous multifocal tumors in a solitary kidney: a case report. 重复机器人肾保留手术治疗单肾异时性多灶性肿瘤1例报告。

Journal of Medicine and Life Pub Date : 2025-04-01 DOI: 10.25122/jml-2025-0059

Stelian Ianiotescu, Constantin Gingu, Irina Balescu, Nicolae Bacalbasa, Ioanel Sinescu

{"title":"Repeat robotic nephron-sparing surgery for metachronous multifocal tumors in a solitary kidney: a case report.","authors":"Stelian Ianiotescu, Constantin Gingu, Irina Balescu, Nicolae Bacalbasa, Ioanel Sinescu","doi":"10.25122/jml-2025-0059","DOIUrl":"10.25122/jml-2025-0059","url":null,"abstract":"We report the case of a 58-year-old male with metachronous renal tumors and a solitary kidney who had previously undergone an open right radical nephrectomy with extended lymphadenectomy for an invasive renal cell carcinoma (RCC) (pT3a N0M0) in November 2013. In May 2022, during routine surveillance, a left lower pole lesion measuring 2.5 × 2 × 1.6 cm was detected, and the patient was submitted to robot-assisted partial nephrectomy (RAPN). The histopathological study confirmed the presence of a pT1a Fuhrman grade 3 clear cell renal carcinoma. In October 2024, follow-up imaging revealed a new upper pole lesion measuring 4 × 3 × 2.3 cm in the left kidney. The patient was submitted to a novel robot-assisted partial nephrectomy, which was successfully completed using selective clamping of the renal artery. The clamping time was 28 minutes (versus 17 minutes during the initial procedure), and the estimated blood loss increased to approximately 300 mL compared to about 100 mL previously, with a console time of 98 minutes. The patient was discharged after the second surgery in good functional status. The final pathology revealed clear cell RCC, Fuhrman grade 2/nucleolar grade 2 (WHO/ISUP 2016), and pT1a, with negative margins. Despite increased technical challenges during reoperation, postoperative renal function remained stable, underscoring the feasibility of repeat RAPN in a solitary kidney.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"393-396"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translating theory into practice: students' lived experiences on the utilization of OSVE and role-play for acquiring psychiatric nursing competencies. 将理论转化为实践：学生利用OSVE和角色扮演获得精神科护理能力的生活经验。

Journal of Medicine and Life Pub Date : 2025-04-01 DOI: 10.25122/jml-2024-0383

Amal Ibrahim Khalil, Samirh Said Alqhtani

{"title":"Translating theory into practice: students' lived experiences on the utilization of OSVE and role-play for acquiring psychiatric nursing competencies.","authors":"Amal Ibrahim Khalil, Samirh Said Alqhtani","doi":"10.25122/jml-2024-0383","DOIUrl":"10.25122/jml-2024-0383","url":null,"abstract":"Developing key competencies like communication, empathy, and critical decision-making is crucial in psychiatric nursing education to prepare students for complex clinical environments. This study explored nursing students' experiences in using objective structured video examination (OSVE) and role-play to develop essential psychiatric nursing competencies. A qualitative approach was used, gathering data through focus group discussions and individual interviews with students in a psychiatric nursing course. Various themes emerged, highlighting the advantages and limitations of each teaching method. OSVE offered structured scenarios that improved clinical reasoning and self-assessment, while role-play encouraged real-time interactions and adaptive thinking. Students found that OSVE helped them connect theoretical knowledge to practical applications by allowing them to observe and analyze model behaviors in different psychiatric situations. On the other hand, role-play promoted deeper engagement through realistic patient interactions, boosting confidence and emotional readiness. However, students also faced challenges like performance anxiety during role-play and the need for guidance in OSVE sessions. This study emphasizes the complementary nature of OSVE and role-play in enhancing psychiatric nursing competencies and suggests integrating both methods for comprehensive skill development. The findings offer valuable insights for educators to enhance teaching strategies in psychiatric nursing education, aligning with evidence-based practices to meet student learning needs.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 4","pages":"364-374"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of dietary and lifestyle interventions in obesity management: a therapeutic protocol at the Diabetes Department, Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. 饮食和生活方式干预在肥胖管理中的功效：罗马尼亚布加勒斯特Marius Nasta肺病研究所糖尿病科的治疗方案。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0417

Oana-Andreea Parlițeanu, Simona Carniciu, Alina Spinean, Cristiana Voineag, Beatrice Mahler

{"title":"Efficacy of dietary and lifestyle interventions in obesity management: a therapeutic protocol at the Diabetes Department, Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania.","authors":"Oana-Andreea Parlițeanu, Simona Carniciu, Alina Spinean, Cristiana Voineag, Beatrice Mahler","doi":"10.25122/jml-2024-0417","DOIUrl":"https://doi.org/10.25122/jml-2024-0417","url":null,"abstract":"The primary objective of this study was to underline the importance of comprehensive medical education in the management of obesity. In clinical practice, patients frequently encounter challenges in achieving weight-related goals. Given that obesity is a major cause of global mortality, we aimed to evaluate the effectiveness of implementing targeted educational interventions on patient outcomes. To this end, we developed a specific dietary plan and educational materials for lifestyle modification administered to 44 patients in the Diabetes Department of Marius Nasta Institute of Pneumophthisiology in Bucharest, Romania. Assessments were conducted at baseline and after a three-month intervention period. The total body weight loss was 11%. BMI reductions were reflected in the redistribution of obesity types. The number of overweight individuals increased from 10 men (22.72%) to 13 men and 5 women, totaling 18 individuals (40.90%, with 29.54% men and 11.36% women). Blood glucose values dropped by 5%, and levels of HbA1c dropped by 0.4% from baseline to follow-up. The SAS severe group went down from 16 patients to 10 patients, and there was an increase in the mild Sleep Apnea Syndrome (SAS) group, increasing from 8 to 14, resulting in a 13.63% overall increase. Our findings indicate that enhanced engagement by the therapeutic team, combined with detailed educational resources and adequate time for their comprehension, improved patient health outcomes, led to weight reduction and a reduction in the severity of comorbidities such as hypertension, dyslipidemia, and sleep apnea, which translated to improved quality of life.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"208-213"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced rehabilitation after surgery: principles in the treatment of emergency complicated colorectal cancers - a narrative review. 加强术后康复：急诊复杂结直肠癌治疗原则综述

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0049

Alexandra-Ana Mihailescu, Sebastian Gradinaru, Alin Kraft, Corneliu-Dan Blendea, Bogdan-Sorin Capitanu, Stefan Ilie Neagu

{"title":"Enhanced rehabilitation after surgery: principles in the treatment of emergency complicated colorectal cancers - a narrative review.","authors":"Alexandra-Ana Mihailescu, Sebastian Gradinaru, Alin Kraft, Corneliu-Dan Blendea, Bogdan-Sorin Capitanu, Stefan Ilie Neagu","doi":"10.25122/jml-2025-0049","DOIUrl":"https://doi.org/10.25122/jml-2025-0049","url":null,"abstract":"Enhanced Recovery After Surgery (ERAS) protocols are used in elective colorectal surgeries and have shown improved recovery for many patients. However, using these protocols in emergency colorectal surgery, especially in complicated cases of obstructive colorectal cancer, is still debated. This review examined the ERAS principles that can be adapted for emergencies. We reviewed the literature on applying ERAS principles in emergency colorectal cancer surgery. We analyzed key strategies used before, during, and after surgery. The aim of ERAS in emergency colorectal surgery is to reduce physical stress from urgent surgical conditions. Before surgery, the focus should be on early patient recovery, managing blood sugar levels, and providing patient education when possible. Minimally invasive techniques, careful fluid management, and effective pain relief during surgery are intraoperative key points. After surgery, early feeding, patient mobilization, and minimizing the use of medical devices are encouraged. Studies have shown that using ERAS in emergencies can lower mortality, reduce hospital stays, and influence patient recovery rates, although it may lead to higher initial costs. Still, following ERAS in emergencies is inconsistent due to logistical issues and patient health changes. More people are starting to recognize the benefits of ERAS in obstructive colorectal cancer surgery. Although there is less evidence compared to elective procedures, new studies suggest that organized steps for care can improve patient outcomes. Further research is needed to improve ERAS emergency protocols and identify patients suitable for this approach so that healthcare resources can be used better.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"179-187"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic assessment of the inflammatory response in military personnel: a pilot study on ΔNLR and composite markers in operational environments. 军事人员炎症反应的动态评估：作战环境中ΔNLR和复合标志物的试点研究。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0056

Florina-Diana Mihai, Emil-Tiberius Trasca, Dumitru Radulescu, Patricia-Mihaela Radulescu, Razvan Mercut, Elena-Irina Caluianu, Eleonora Daniela Ciupeanu-Calugaru, Dan Marian Calafeteanu, Georgiana-Andreea Marinescu, Suzana Danoiu

{"title":"Dynamic assessment of the inflammatory response in military personnel: a pilot study on ΔNLR and composite markers in operational environments.","authors":"Florina-Diana Mihai, Emil-Tiberius Trasca, Dumitru Radulescu, Patricia-Mihaela Radulescu, Razvan Mercut, Elena-Irina Caluianu, Eleonora Daniela Ciupeanu-Calugaru, Dan Marian Calafeteanu, Georgiana-Andreea Marinescu, Suzana Danoiu","doi":"10.25122/jml-2025-0056","DOIUrl":"https://doi.org/10.25122/jml-2025-0056","url":null,"abstract":"In this pilot study, we investigated immune alterations in 178 military personnel exposed to extreme operational stress. We focused on the neutrophil-to-lymphocyte ratio (NLR) and its change (ΔNLR) alongside composite inflammatory indices- Systemic Inflammation Response Index (SIRI), Systemic Immune-Inflammation Index (SII), and Inflammatory Index Cumulative (IIC). Blood analyses performed before and after deployment revealed a significant post-mission increase in NLR (1.9671±±±0.9174 vs. 1.6079±±±0.4973 pre-deployment), yielding an average ΔNLR of 0.3592±±±0.7642 (P < 0.0001). While basophil counts and several biochemical markers remained stable, notable changes in neutrophils and composite indices suggest a complex inflammatory activation. Importantly, correlation analyses confirmed that despite marked shifts in absolute values, the relative relationships between pre- and post-deployment measurements (e.g., NLR: r = 0.5533, P < 0.0001) were maintained. These findings imply that ΔNLR, together with SIRI, SII, and IIC, may serve as valuable biomarkers for dynamically monitoring the inflammatory response in military contexts, thereby enabling early identification of individuals at increased inflammatory risk.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"257-264"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of concurrent HIV infection in the course and management of Crohn's disease. 克罗恩病过程中并发HIV感染的挑战和管理。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0359

Lamyaa Mattar, Husna Irfan Thalib, Meral Alnuwaimi, Hanin Alsaadi, Huda Ahmed Allouji, Jena Alyafei, Layan Alshowiman, Nuran Alsobyani, Fatma El Sayed Hassan

{"title":"Challenges of concurrent HIV infection in the course and management of Crohn's disease.","authors":"Lamyaa Mattar, Husna Irfan Thalib, Meral Alnuwaimi, Hanin Alsaadi, Huda Ahmed Allouji, Jena Alyafei, Layan Alshowiman, Nuran Alsobyani, Fatma El Sayed Hassan","doi":"10.25122/jml-2024-0359","DOIUrl":"https://doi.org/10.25122/jml-2024-0359","url":null,"abstract":"Crohn's disease (CD) is a chronic transmural bowel inflammation with a multifactorial etiology involving genetic predisposition and immune dysregulation in response to environmental triggers. In patients with human immunodeficiency virus (HIV), an already compromised immune system further complicates the progression and management of CD, creating unique therapeutic challenges. Probiotics have recently gained attention as a potential therapeutic option for CD, especially due to their role in modulating the gut microbiota. However, their effectiveness in patients with HIV, especially in enhancing and maintaining remissions, remains underexplored. This review aimed to examine how HIV infection influences the course of inflammatory bowel disease (IBD) and its impact on CD management strategies. A systematic literature search was conducted using Google Scholar, PubMed, Springer, and Web of Science to identify studies on patients with HIV and CD. HIV infection significantly alters the progression and management of CD due to its impact on the immune system. The immunosuppressed state of patients with HIV can complicate both the diagnosis and treatment of CD, often requiring adjustments in therapeutic approaches, necessitating a careful, tailored approach.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical and non-surgical management of spondylolisthesis: a comprehensive review. 脊柱滑脱的手术和非手术治疗：全面回顾。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0039

Dana-Georgiana Nedelea, Diana Elena Vulpe, Florentina Gherghiceanu, Bogdan Sorin Capitanu, Serban Dragosloveanu, Ioan Cristian Stoica

{"title":"Surgical and non-surgical management of spondylolisthesis: a comprehensive review.","authors":"Dana-Georgiana Nedelea, Diana Elena Vulpe, Florentina Gherghiceanu, Bogdan Sorin Capitanu, Serban Dragosloveanu, Ioan Cristian Stoica","doi":"10.25122/jml-2025-0039","DOIUrl":"https://doi.org/10.25122/jml-2025-0039","url":null,"abstract":"Spondylolisthesis is a spinal condition characterized by the forward or backward displacement of a vertebral body, most commonly affecting the lower lumbar spine. It can be classified into different types, with isthmic and degenerative being the most prevalent. Early diagnosis is essential to initiate appropriate treatment based on symptom severity, degree of slippage, and neurological deficits. Non-surgical management is the first-line approach for low-grade spondylolisthesis (Grade I-II) and includes physical therapy, activity modification, pain management with nonsteroidal anti-inflammatory drugs or epidural steroid injections, and, in some cases, bracing. While most patients experience symptom relief with conservative treatment, those with progressive neurological deficits, severe pain, or significant instability may require surgery. Surgical options typically include decompression for nerve compression and fusion to stabilize the spine. The choice between decompression alone and decompression with fusion remains controversial, particularly in degenerative spondylolisthesis without initial instability. Posterior lumbar interbody fusion and transforaminal lumbar interbody fusion are the most performed techniques, with minimally invasive surgery gaining popularity due to its less aggressive impact on tissues and faster recovery. Long-term follow-up is necessary to monitor for complications such as adjacent segment disease, pseudarthrosis, or reoperation rate. Advances in imaging, surgical navigation, and regenerative medicine are important for the future of spondylolisthesis treatment, but current management remains centered on optimizing patient outcomes through individualized care and evidence-based treatment selection.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"196-207"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches. 单胺类神经递质转运障碍的比较研究：机制、临床表现和治疗方法。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2024-0398

Rand Redwan Al Sari, Husna Irfan Thalib, Syeda Sobiah Imad, Sariya Khan, Shyma Haidar, Bayan Mohammed Khair Al Zoabi, Sahar Hamed Fadda, Samratul Fuadah, Hassan Abu Alwan, Abdullah Alghobaishi

{"title":"A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches.","authors":"Rand Redwan Al Sari, Husna Irfan Thalib, Syeda Sobiah Imad, Sariya Khan, Shyma Haidar, Bayan Mohammed Khair Al Zoabi, Sahar Hamed Fadda, Samratul Fuadah, Hassan Abu Alwan, Abdullah Alghobaishi","doi":"10.25122/jml-2024-0398","DOIUrl":"https://doi.org/10.25122/jml-2024-0398","url":null,"abstract":"Neurotransmitters play important roles in brain function, influencing cognition, movement, and behavior. Disruption in neurotransmitter biosynthesis, expression, transport, or function due to genetic mutations can lead to various neurological and psychiatric disorders with variable age of onset. Catecholamines like dopamine, norepinephrine, epinephrine, and serotonin are key monoamines transported by specific transporters, including the dopamine transporter (DAT) and the vesicular monoamine transporter 2 (VMAT2). Disorders that involve monoamine neurotransmitter transport include dopamine transporter deficiency syndrome (DTDS) and brain dopamine-serotonin vesicular disorders (PKDYS2). These rare syndromes manifest with movement disorders and neuropsychiatric symptoms. DTDS results from a mutation in the SLC6A3 gene affecting dopamine reuptake, while PKDYS2 involves a mutation in the SLC18A2 gene impairing the transport of dopamine and serotonin. This review provides a comparative analysis of the diagnostic approaches, the management strategies, and the outcomes for these distinct disorders.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and awareness of the health effects of electronic cigarette among college students. 大学生对电子烟健康影响的认知和意识。

Journal of Medicine and Life Pub Date : 2025-03-01 DOI: 10.25122/jml-2025-0016

Saleh Khateeb, Dana Alsuqaie, Sama Sobahi, Danah Muminah, Laila Alyafi, Taif Alotbi

{"title":"Knowledge and awareness of the health effects of electronic cigarette among college students.","authors":"Saleh Khateeb, Dana Alsuqaie, Sama Sobahi, Danah Muminah, Laila Alyafi, Taif Alotbi","doi":"10.25122/jml-2025-0016","DOIUrl":"https://doi.org/10.25122/jml-2025-0016","url":null,"abstract":"Electronic cigarettes (e-cigarettes) are nicotine delivery devices promoted as a safer alternative to traditional smoking; however, their long-term health effects remain uncertain. Their use is rapidly increasing worldwide, particularly among young adults. In Jeddah, Saudi Arabia, there is limited information on e-cigarette usage among college students. This study aimed to assess the level of knowledge and awareness regarding the health effects of e-cigarettes among college students in Jeddah through a cross-sectional, survey-based study conducted in 2024 with 438 participants. Data were collected using a pre-validated self-administered questionnaire distributed via various social media platforms. Categorical variables were compared using the chi-square test. Results indicated that 54.8% of respondents reported previous smoking experience. Among the participants, 29.7% believed that e-cigarettes are an effective smoking cessation method, 50.5% viewed them as a potential replacement for traditional cigarettes, and 43.2% considered e-cigarettes a gateway to conventional smoking. Overall, 39.3% of respondents demonstrated good knowledge about e-cigarettes, with significant differences observed between age groups, genders, smoking experience (P < 0.001), and educational levels (P < 0.002). Additionally, 54.3% of respondents expressed a negative attitude toward e-cigarettes, with statistically significant differences across groups (P < 0.001). Given the relatively high prevalence of smoking among college students in Jeddah and their overall insufficient knowledge about e-cigarettes, these findings underscore the urgent need to raise awareness about the risks associated with e-cigarette use and to implement appropriate regulatory measures.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 3","pages":"235-245"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0