Journal of Medicine and Life最新文献

{"title":"Beyond the bone marrow: a review of therapeutic approaches for extramedullary disease in multiple myeloma and the significance of MRD assessment.","authors":"Daniela Diaconescu, Dan Sebastian Soare, Cristina Elena Marinescu, Georgiana Elena Ene, Horia Bumbea","doi":"10.25122/jml-2025-0104","DOIUrl":"10.25122/jml-2025-0104","url":null,"abstract":"<p><p>Extramedullary disease (EMD) in multiple myeloma (MM) represents a distinct clinical entity associated with poor prognosis, therapeutic resistance, and aggressive behavior. EMD can occur at diagnosis or during relapses, either contiguous with bone lesions or as soft tissue plasmacytomas due to hematogenous spread. This review outlines the current understanding of EMD pathophysiology, diagnostic challenges, and therapeutic approaches. The review differentiates between bone-related and non-bone-related EMD, highlighting their prognostic implications. Diagnostic strategies rely on advanced imaging modalities, including PET-CT and MRI, and require histopathological confirmation through biopsy and immunohistochemistry. Management includes local therapies, primarily radiotherapy and, in selected cases, surgery, alongside systemic treatments involving proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. New emerging therapies, such as chimeric antigen receptor T cells (CAR-T) and bispecific antibodies, are under evaluation for the treatment of relapsed/refractory EMD. Autologous stem cell transplantation is recommended for eligible patients, with tandem procedures considered in high-risk cases. The role of minimal residual disease (MRD) monitoring is emphasized, employing next-generation sequencing (NGS), flow cytometry, and imaging, with MRD negativity serving as a surrogate marker for treatment efficacy and survival prediction. Despite therapeutic advances, the prognosis for patients with EMD remains unfavorable. The review underscores the necessity of a multidisciplinary approach for accurate diagnosis, individualized treatment, and consistent monitoring. Recognizing EMD as a high-risk MM variant mandates the integration of novel diagnostics and therapies. Future clinical trials must incorporate EMD-specific endpoints to optimize treatment and improve outcomes.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"536-544"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-cell acute lymphoblastic leukemia and lymphoblastic lymphoma with p190 <i>BCR::ABL1</i> transcript: a case report.","authors":"Budiono Raharjo, Catherine Keiko Gunawan, Stephani Linggawan, Siprianus Ugroseno Yudho Bintoro, Anton Sumarpo","doi":"10.25122/jml-2025-0020","DOIUrl":"10.25122/jml-2025-0020","url":null,"abstract":"<p><p>Lymphoblastic lymphoma (LBL) is a rare and aggressive lymphoblastic neoplasm, accounting for approximately 2% of non-Hodgkin lymphoma cases. Despite sharing clinical and morphological similarities with acute lymphoblastic leukemia (ALL), LBL is characterized by distinct genetic abnormalities. Due to the ambiguity surrounding treatments, the prognosis for LBL remains poor, with complete remission rates between 40-58% and 5-year disease-free survival rates between 36-70%. We present a case of a 42-year-old man diagnosed with B-acute lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (LBL). The diagnosis was challenging due to the rarity of the condition and the overlapping features of LBL and ALL. This case report highlights the predominance of lymphoblasts and the presence of the p190 (e1a2) <i>BCR::ABL1</i> transcript, which is frequently associated with poor prognostic outcomes in lymphoblastic malignancies. The coexistence of both B-ALL and LBL underscores the necessity of a comprehensive understanding of the diagnostic approach, which is essential for optimizing treatment strategies and improving prognosis.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"600-603"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noise-induced hearing loss among military personnel in Saudi Arabia: a preliminary study.","authors":"Ahmad Alanazi, Abrar AlMutairi, Fulwah AlHargan","doi":"10.25122/jml-2025-0013","DOIUrl":"10.25122/jml-2025-0013","url":null,"abstract":"<p><p>Noise-induced hearing loss (NIHL) is a leading cause of sensorineural hearing loss (SNHL), with significant global prevalence. Occupational, environmental, and recreational noise exposure has heightened concerns about NIHL in Saudi Arabia. Despite general awareness of noise-related auditory risks, misconceptions about safe exposure durations and listening practices persist. This cross-sectional preliminary study investigated the effects of noise exposure on military personnel in Riyadh, Saudi Arabia, using a structured approach that included case histories and audiological assessments. The study included 40 male participants, primarily aged 41-50 years, with an extensive military service. Case histories and audiological assessments revealed that 77.5% experienced prolonged occupational noise exposure. Tinnitus was the most common symptom (60%), and bilateral hearing loss was more prevalent (87.5%) than unilateral. Audiometric findings revealed distinct SNHL profiles among the participants, particularly those with prolonged exposure durations. While prolonged exposure correlated with more severe hearing loss, statistical significance was not achieved (<i>P</i> = 0.60). The participants with more than 2 years of experience reported tinnitus (61.8%) and dizziness (14.7%). The findings align with global evidence linking military environments to the high prevalence of NIHL due to hazardous noise levels. Bilateral SNHL patterns and the predominance of tinnitus underscore the cumulative auditory damage associated with chronic exposure. The study emphasizes the importance of implementing effective hearing conservation programs, which include regular auditory assessments, mandatory use of hearing protection, and education on the risks of NIHL. Addressing these factors is critical to mitigating the societal and occupational impacts of NIHL in Saudi Arabia.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"552-556"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of thyroid scan and ultrasound in managing thyroglossal cysts: a systematic literature review.","authors":"Wafaa Taishan, Mohammad Alessa, Majd Alsaleh, Turki Althunayyan, Rakan Almesned, Saleh Alessy, Hashem Alsaab, Jabir Alharbi, Sherif Abdelmonim, Ameen Alherabi, Haddad Alkaf, Mohammed Alqaddi, Ahmed Bahaj","doi":"10.25122/jml-2025-0006","DOIUrl":"10.25122/jml-2025-0006","url":null,"abstract":"<p><p>Thyroglossal duct cysts (TGDCs) are the most common congenital neck masses, frequently diagnosed in both pediatric and adult populations. Accurate preoperative diagnosis and imaging are essential for effective management. Ultrasound (US) and thyroid scintigraphy are the primary imaging modalities used in clinical practice. This systematic review evaluates the diagnostic utility of US and thyroid scintigraphy in the management of TGDCs, comparing their diagnostic performance and assessing whether a combined imaging approach improves patient care. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant studies assessing the diagnostic roles of US and thyroid scintigraphy in TGDCs were identified through comprehensive searches of PubMed, Web of Science, Scopus, and ScienceDirect, with the final search conducted on May 5, 2024. A total of 18 studies involving 823 patients met the inclusion criteria. The results consistently showed that ultrasound is the preferred imaging modality, offering noninvasive, radiation-free, and highly accurate diagnostic capabilities. Ultrasound confirmed TGDC diagnosis in 66.1% of cases across studies, with detailed anatomical imaging supporting preoperative planning. Thyroid scintigraphy, while useful in cases of suspected ectopic thyroid tissue, was less frequently employed and generally unnecessary when a normal thyroid was identified on ultrasound. The Sistrunk procedure remains the preferred surgical intervention, with preoperative US proving essential in planning. Ultrasound is the most effective and noninvasive imaging tool for diagnosing TGDCs and planning preoperative interventions. Thyroid scintigraphy should be reserved for selected cases in which ectopic thyroid tissue is suspected. The findings support the use of ultrasound as the primary imaging modality, with thyroid scanning playing a secondary and more selective role in the management of TGDC.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"517-525"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational diseases among dental personnel: a scoping review.","authors":"Florentina Căminișteanu, Andrei Vorovenci, Viorel Ștefan Perieanu, Sergiu-Adrian Petri, Liliana Burlibașa, Mihai David, Andi Ciprian Drăguș, Mihai Burlibașa","doi":"10.25122/jml-2024-0412","DOIUrl":"10.25122/jml-2024-0412","url":null,"abstract":"<p><p>Dental professionals face numerous occupational health risks that can significantly impact their well-being and career longevity. This scoping review synthesizes current evidence on the prevalence, risk factors, and prevention strategies for major occupational health issues in dentistry. The article selection process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive electronic search was conducted across PubMed/MEDLINE, Scopus, and Web of Science to identify relevant studies published within the past decade. Musculoskeletal disorders (MSDs) were found to be highly prevalent. Allergic contact dermatitis (ACD), pulmonary diseases such as pneumoconiosis, and noise-induced hearing loss (NIHL) remain common concerns for the overall health of dental personnel. Work-related stress is widespread and can lead to mental health issues such as burnout syndrome, emotional exhaustion, and suicidal ideation. Occupational health issues are prevalent in dentistry, necessitating the development of improved prevention strategies. Recommended preventive measures include ergonomic workplace design, regular physical activity, stress management techniques, the use of appropriate personal protective equipment, and efficient ventilation systems. Future research should focus on developing standardized diagnostic criteria and employing prospective cohort designs to more accurately estimate disease burden and evaluate the effectiveness of interventions.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"526-535"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does gender affect intraocular lens power calculations? A comparative analysis of formula accuracy.","authors":"Ionela-Iasmina Yasar, Servet Yasar, Leila Al Barri, Diana-Maria Darabus, Alina Iasmina Dumitriu, Mihnea Munteanu, Horia Tudor Stanca","doi":"10.25122/jml-2025-0091","DOIUrl":"10.25122/jml-2025-0091","url":null,"abstract":"<p><p>Intraocular lens (IOL) power calculation is a crucial aspect of modern cataract surgery, directly affecting postoperative refractive outcomes. Due to anatomical and physiological differences between male and female eyes, neglecting gender-specific variations may lead to systematic refractive errors in IOL power selection. This research aimed to determine the necessity of incorporating gender as a variable in future IOL calculation algorithms to improve postoperative precision. This retrospective observational study analyzed data from 210 eyes that met predefined inclusion criteria. Biometric measurements for assessing intraocular lens power were obtained using the ARGOS optical biometer. The refractive power of the intraocular lenses was calculated using several established formulas, and these values were systematically compared to evaluate their predictive accuracy. A parametric statistical approach was employed, using repeated measures ANOVA to assess differences among multiple calculations. The homogeneity of covariances was examined to validate the design of the repeated measures. Pairwise comparisons of the outcomes from different formulas were performed using the Bonferroni correction to identify statistically significant differences. Additionally, paired-sample <i>t</i>-tests were conducted to compare the spherical equivalent values recorded during the initial and final follow-up examinations. Significant differences were observed between genders regarding descriptive features such as age, axial length, keratometry, and white-to-white measurements. Although notable biometric differences exist between genders, they do not seem to affect the discrepancies in intraocular lens power calculations using the tested formulas. However, intra-group differences in intraocular power values suggest that the choice of formula may impact predicted intraocular power differently for men and women.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"557-562"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging characteristics of small cell and non-small cell lung cancer brain metastases: a retrospective study.","authors":"Daniela Pomohaci, Emilia Adriana Marciuc, Bogdan-Ionuț Dobrovăț, Mihaela-Roxana Popescu, Diana-Andreea Ilinca, Costin Chirica, Oriana-Maria Oniciuc Onicescu, Danisia Haba","doi":"10.25122/jml-2024-0411","DOIUrl":"10.25122/jml-2024-0411","url":null,"abstract":"<p><p>Brain metastases (BMs) from bronchopulmonary tumors are a major cause of morbidity and mortality and significantly reduce the quality of life in oncology patients. Their treatment depends on imaging features (size, number, location) and their genetic mutation subtype, small-cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC). In patients with SCLC, prophylactic whole-brain radiotherapy (WBRT) with hippocampal sparing (HS) is recommended, whereas in patients with NSCLC, systemic targeted therapy is preferred. Multiple studies have analyzed the MRI morphology of BMs from both SCLC and NSCLC to identify specific imaging characteristics that can guide the selection of appropriate treatment. However, data on lung cancer (LC) brain metastases in patients from Romania are scarce or nonexistent. Our purpose was to investigate the imaging features of both NSCLC and SCLC BMs in our population using conventional MRI protocols. We selected patients from our hospital between 2019 and 2023 who had a histopathological diagnosis of LC BMs and underwent complete MRI exams prior to any radiotherapy or surgical treatment. For every MRI feature, we created both numerical and categorical variables, which were further studied using univariate, bivariate, and multivariate analyses, as well as a machine learning algorithm. We found 62 patients (49 men, 79.03% and 13 women, 20.96%) with confirmed LC BMs, of which 53 (85.49%) had NSCLC and 7 (11.29%) had SCLC. The sites affected were the cerebral hemisphere (56.46%), the cerebellum (40.32%), and the deep nuclei (6.45%), with the latter affecting relatively younger patients (<i>P</i> = 0.01), most notably in the case of thalamic situs (<i>P</i> = 0.0001). The SCLC subgroup showed a <i>P</i> value of 0.025 for the number of lesions, indicating diffuse spread. The AI algorithm identified positive and negative imaging diagnostic prediction variables, including internal vascularization and the number of lesions, respectively, as well as cystic lesions and internal hemorrhage. Further multicentric studies are needed to unravel the MRI features of LC BMs.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"563-574"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of biomechanical features in orthopedic spine disorders: a study on predictive factors for spinal abnormalities.","authors":"Abdulsalam Mohammed Aleid, Nouf Abdullah Alyabis, Abdulrahman Ahmed Almebki, Faisal Dhafer Alshehri, Abdulelah Mohammed Asiri, Yezeid Faisal Almohsen, Renad Fahad Almymoni, Ryan Khater Alanzi, Bayan Eid Alzahrani, Eid Khaled Algaman, Loai Saleh Albinsaad, Saud Nayef Salem Aldanyowi","doi":"10.25122/jml-2024-0336","DOIUrl":"10.25122/jml-2024-0336","url":null,"abstract":"<p><p>Abnormal spine biomechanics are associated with various orthopedic disorders. Identifying key biomechanical factors predictive of spinal abnormalities can improve diagnosis and treatment. This study aimed to determine whether specific pelvic biomechanical parameters are significant predictors of spinal abnormalities. We hypothesized that patients with abnormal spine conditions exhibit distinct pelvic measurements compared to those with normal spine conditions. A retrospective analysis was conducted on 1,181 patient records from January to March 2024, focusing on pelvic incidence (PI), pelvic tilt (PT), lumbar lordosis (LL), sacral slope (SS), pelvic radius (PR), and spondylolisthesis. Data were collected from a centralized orthopedic patient database, which integrates de-identified records from the author's institution and affiliated facilities under the Ministry of Health. This ensured a standardized approach to data entry, with regular audits to maintain accuracy and reliability. Patients' spine conditions were classified as normal or abnormal based on imaging and clinical examinations. Descriptive statistics summarized the data, and comparative analyses were performed to differentiate between normal and abnormal groups. Decision trees and logistic regression were used to identify significant predictors of spinal abnormalities. Model validation was performed using ROC analysis and 10-fold cross-validation. Preliminary analysis found significant differences between normal and abnormal groups for various factors. Logistic regression identified pelvic incidence, lumbar lordosis, sacral slope, and pelvic radius as significant predictors (<i>P</i> < 0.05). Decision trees classified 69.5% of cases accurately based on pelvic incidence thresholds. Models were validated using ROC analysis (AUC > 0.7) and 10-fold cross-validation (accuracy > 60%). This study provides valuable insights into spine biomechanics by identifying key predictors of spinal abnormalities, particularly pelvic incidence. The decision tree and logistic regression models demonstrated strong predictive capabilities. While prior studies have identified correlations between pelvic parameters and spinal disorders, this research quantifies these associations through predictive modeling, offering practical applications for early diagnosis and intervention. These findings offer the potential for improved diagnostic and treatment strategies for spine disorders. Further prospective studies are necessary to validate these results and enhance predictive models.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"545-551"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A peculiar case report of primary iTTP in a previously healthy Saudi man.","authors":"Aishwarya Balasubramanian, Bader AlMurad, Nada AlFarrah, Bakr AbuSamrah, Nawal AbulKhoudoud","doi":"10.25122/jml-2024-0415","DOIUrl":"10.25122/jml-2024-0415","url":null,"abstract":"<p><p>A 43-year-old Saudi man with prediabetes presented with epigastric pain and thrombocytopenia, initially treated as immune thrombocytopenia with dexamethasone. The patient's condition worsened as he developed a rash and hematuria, prompting hospital transfer and a severe drop in platelet count. Despite platelet transfusions and steroids, he showed no improvement, leading to a suspected diagnosis of thrombotic thrombocytopenic purpura (TTP). The patient's anti-nuclear antibody (ANA) test result was positive. This may be because individuals are more likely to develop an autoimmune disease for up to 12 years following an acute TTP episode. After initial plasmapheresis sessions, he was admitted to the ICU for further management. Diagnostic workup, including ADAMTS13 assay, confirmed primary immune-mediated thrombotic thrombocytopenic purpura (iTTP), leading to the initiation of plasmapheresis and rituximab. After he responded to therapy, plasma exchange (PEX) was discontinued, and his platelet count began to decline. On the third day after discontinuation, his platelet count decreased to 80,000 x 10⁹/L, necessitating the restart of PEX. During treatment, the patient experienced transient neurological symptoms and developed a pulmonary embolism, which was managed with anticoagulation. Plasmapheresis and immunosuppressive therapy resulted in clinical improvement in stabilizing platelet counts, and he was discharged in good condition after 16 sessions of plasmapheresis and three doses of rituximab. This case highlights the diagnostic challenges in atypical TTP presentations and underscores the importance of promptly identifying TTP and initiating aggressive therapy.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"594-599"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berg Balance Scale in post-COVID-19 patients: results from a retrospective study.","authors":"Ovidiu Cristian Chiriac, Daniela Miricescu, Corina Sporea, Ana Raluca Mitrea, Silviu Stanciu, Raluca Mititelu, Raluca Grigore, Sarah Adriana Nica","doi":"10.25122/jml-2025-0098","DOIUrl":"10.25122/jml-2025-0098","url":null,"abstract":"<p><p>SARS-CoV-2 infection has been linked to sedentary behavior, which can lead to musculoskeletal weakness, cardiometabolic disorders, and a worsening of pre-existing conditions, particularly in older patients. The primary aim of our study was to compare the Berg Balance Score (BBS), comprising BBS1 (sit to stand), BBS2 (standing unsupported), and BBS3 (sitting unsupported), in patients with mild and moderate post-COVID-19 symptoms before and after the recovery program. BBS1, BBS2, and BBS3 demonstrated statistically significant improvement after the recovery program for both men and women compared to the initial assessment (<i>P</i> < 0.001). In terms of age, BBS1, BBS2, and BBS3 were significantly higher in patients over 60 years old (<i>P</i> < 0.001). Statistically significant differences were observed between BBS1 in patients over 60 and those under 60 years (<i>P</i> = 0.008). Significant negative correlations were found between age and BBS1 (<i>P</i> = 0.001; R = -0.267). Significant positive correlations were noted between BBS1 and BBS2 (<i>P</i> < 0.001; R = 0.827), BBS1 and BBS3 (<i>P</i> < 0.001; R = 0.796), and BBS2 and BBS3 (<i>P</i> < 0.001; R = 0.926). The recovery program implemented for post-COVID-19 patients significantly improved BBS subitems, positively impacting motor function.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"18 6","pages":"580-589"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}