Journal of Multidisciplinary Healthcare最新文献

{"title":"Translating Patient Experiences Into Multimethod Assessment and Evidence-Based Care: Next Steps in Research on Sleep Disturbance in Acute Leukemia [Letter].","authors":"Fei-Yi Zhao, Qiang-Qiang Fu, Chin Moi Chow","doi":"10.2147/JMDH.S564408","DOIUrl":"10.2147/JMDH.S564408","url":null,"abstract":"","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5833-5835"},"PeriodicalIF":2.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Privatization of Healthcare Services from the Nursing Perspective in the Kingdom of Saudi Arabia: A Cross-Sectional Study.","authors":"Ahmed Sadoun Al-Sadoun, Nourah Obaid Al-Otaibi, Hanan Hussien Al-Ahmari, Dalal Othman Adawi, Laila Matrouk Al-Dalbahi, Regie Buenafe Tumala","doi":"10.2147/JMDH.S500877","DOIUrl":"10.2147/JMDH.S500877","url":null,"abstract":"<p><strong>Background: </strong>While the privatization of healthcare services holds a potential for better healthcare outcomes, a significant gap remains in understanding its impact on the healthcare workforce, especially regarding nurses' perceptions, with limited research available in the Kingdom of Saudi Arabia (KSA).</p><p><strong>Aim: </strong>This study aimed to assess nurses' perceptions of privatization practices in healthcare services in Al-Taif City, KSA.</p><p><strong>Methods: </strong>This quantitative study used a cross-sectional design. The Nurses' Privatization Perception Scale (NPPS) was distributed electronically to potential respondents in four select hospitals in Al-Taif City, KSA. The random sampling technique was used to recruit a total convenient sample of 237 registered nurses. The IBM SPSS (version 25) was used to analyze the collected survey data.</p><p><strong>Results: </strong>The findings indicated that nurses generally hold a positive perspective of privatization, aligning with their favorable perceptions across three dimensions of the NPPS: (1) privatization in general, (2) privatization in healthcare, and (3) impact of privatization on nursing. Significant differences in the overall perceptions of privatization across all three domains were observed, influenced by factors such as the age, nationality, and working areas of the nurses, as well as to the hospital where the respondents were employed.</p><p><strong>Discussion: </strong>Nurses believed that privatization could yield changes that could positively impact healthcare, the nursing profession and their healthcare practices. This outcome is consistent with the current literature, suggesting that privatization could enable the Saudi government to make decisions more quickly and cut costs.</p><p><strong>Conclusion: </strong>Nurses displayed positive perspective about privatization of healthcare in the KSA. However, more research is required to investigate communication strategies to improve the understanding of the concept of privatization and explore confounding factors influencing nurses' perceptions. This study showed that nurses believed that privatization could bring about positive changes and positively impact healthcare and nurses' practices. The results may aid policymakers in identifying gaps in the understanding of nurses' perceptions of privatization in Al-Taif City and other regions of the KSA, and thus result in awareness programs explaining the value of privatization.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5817-5831"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Machine Learning-Based Clinical Model for Predicting Rupture in Ectopic Pregnancy: A Web-Based Nomogram Approach.","authors":"Xiongying Zhao, Tianchen Wu, Simin Zeng, Xiaoyun Yuan, Xiaoying Liang, Hui Yang, Lihui Ye","doi":"10.2147/JMDH.S536476","DOIUrl":"10.2147/JMDH.S536476","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to develop a predictive model for rupture-associated bleeding in ectopic pregnancy (EP) and to construct a web-based nomogram to support early clinical intervention in women at elevated risk.</p><p><strong>Methods: </strong>Clinical data were retrospectively collected from 543 women with EP at Hexian Memorial Affiliated Hospital of Southern Medical University, Guangzhou, China, between June 2019 and June 2022. Among these, 58 cases were confirmed intraoperatively to have experienced rupture with bleeding. The cohort was randomly divided into training (70%) and validation (30%) subsets. Key predictive variables were selected using the Extreme Gradient Boosting (XGBoost) algorithm, guided by SHapley Additive exPlanations (SHAP) values. Model performance was assessed using the area under the receiver operating characteristic (ROC) curve, calibration analysis, decision curve analysis (DCA), and clinical impact curve (CIC). A web-based nomogram was subsequently developed for clinical implementation.</p><p><strong>Results: </strong>Seven predictive variables were identified and used to construct the model. The ROC curve yielded an area under the curve (AUC) of 0.941 (95% CI: 0.882-0.968) in the training subset and 0.970 (95% CI: 0.9405-0.990) in the validation subset. Calibration curves demonstrated strong concordance between predicted probabilities and observed outcomes. DCA indicated a clinically meaningful predictive probability range between 1% and 94.82%. A dynamic, web-based nomogram was created to facilitate practical application.</p><p><strong>Conclusion: </strong>A clinically applicable predictive model for rupture in EP was developed and validated, incorporating seven key variables. The web-based nomogram enables early risk stratification and intervention, potentially reducing the incidence of rupture-related complications.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5781-5799"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Effectiveness of a Low-Code AI Platform for Developing a Neonatal Multimodal Pain Classification Model.","authors":"Nannan Yang, Xiaosong Jiang, Xue Jin, Xinran Dai, Yuanjing Gu, Huiping Jiang, Liping Pu, Tingqi Shi","doi":"10.2147/JMDH.S531709","DOIUrl":"10.2147/JMDH.S531709","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) has advanced neonatal pain recognition, yet a significant gap persists in translating complex algorithms into practical clinical applications. Low-code AI development platforms, which simplify and automate model creation, offer a potential solution to bridge this gap between research and bedside practice.</p><p><strong>Objective: </strong>This study aimed to explore the feasibility of constructing and validating a neonatal multimodal pain classification model using a commercial low-code AI development platform (EasyDL). The objective was to develop an accessible, cost-effective, and efficient method that empowers clinical professionals to create their own AI tools without extensive programming expertise.</p><p><strong>Methods: </strong>We uploaded 426 neonatal acute pain multimodal data segments to the EasyDL platform and trained a video classification model using its AutoML capabilities. The model underwent internal testing on a held-out dataset portion, followed by external validation on an independent prospective cohort. For external validation, we compared model performance against the N-PASS (Neonatal Pain, Agitation, and Sedation Scale) scores assessed by a senior nurse as the clinical gold standard.</p><p><strong>Results: </strong>The neonatal multimodal pain classification model developed on the platform showed strong performance. Internal validation achieved 89.6% accuracy and an 85.8% F1 score. External validation on unseen data reached 87.7% accuracy, with AUC exceeding 0.95 across all pain categories (no pain, mild pain, severe pain). The streamlined development process enabled seamless API deployment to an Android mobile device for clinical use.</p><p><strong>Conclusion: </strong>Developing a neonatal multimodal pain classification model using a low-code AI platform proves both feasible and effective. The model demonstrates robust performance and strong clinical integration potential. This approach offers a practical pathway to democratize AI development, enabling healthcare professionals to create digital solutions for neonatal pain management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5771-5780"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Knee Angle Specific (60°-90°) Combine versus Isolated Kinetic Chain on Post ACL Recovery Outcomes: A Randomized Control Trial.","authors":"Danish Ali Khan, Ashfaq Ahmad, Hossein Karimi, Asif Hanif, Abdullatif Mansour Almansour, Abdulelah Mansour Almansour, Badr Aldahmash, Ahmed Rady, Mansour I Almansour","doi":"10.2147/JMDH.S528778","DOIUrl":"10.2147/JMDH.S528778","url":null,"abstract":"<p><strong>Background: </strong>The demand for anterior cruciate ligament (ACL) reconstruction is steadily rising, necessitating a comprehensive post-ACL rehabilitation plan to accelerate recovery. This study explores the comparative effects of Open Kinetic Chain (OKC), Closed Kinetic Chain (CKC), and their combined effect at a specific knee angle (60° to 90°) in post-ACL reconstruction patients.</p><p><strong>Methodology: </strong>This clinical trial was registered in the Iranian Registry of Clinical Trials (IRCT) on 21-04-2020 (Ref# IRCT20200331046903N1) and conducted on 54 post-ACL reconstruction patients, randomly allocated to three groups (OKC, CKC, and Combined KC) using the lottery method. All groups underwent 16-week rehabilitation programs. Outcomes assessed were pain, range of motion (ROM), and knee function using the visual analog scale, goniometer, and Lysholm score, respectively. Statistical analysis was conducted using one-way and repeated measures ANOVA in SPSS-25.</p><p><strong>Results: </strong>The mean age was 27.25±4.16 years and BMI 25.12±4.03 kg/m². All groups showed statistically significant improvement over 16 weeks (p<0.0001). At week 16, mean pain scores were 10.56±4.38 (Group A), 9.78±3.81 (Group B), and 3.28±3.12 (Group C) (p<0.001); ROM improved to 131.83±7.35, 129.22±7.57, and 140.61±6.13, respectively (p=0.001); knee function scores reached 90.78±4.83, 91.67±4.49, and 97.50±2.15, respectively (p=0.001). All outcome measures showed significant main effects of Group and Visit, with large effect sizes and significant Group×Visit interactions. From baseline to week 16, pain decreased by 85% (Group A), 86% (Group B), and 95% (Group C); ROM increased by 73%, 72%, and 90%; knee function improved by 58%, 63%, and 72%, respectively.</p><p><strong>Conclusion: </strong>These findings indicate that the combined kinetic chain approach is most effective in improving ROM, knee function, and pain reduction following ACL reconstruction.</p><p><strong>Trial registration: </strong>https://irct.behdasht.gov.ir/.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5801-5815"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Unhealthy Plant-Based Diet with All-Cause Mortality in Chronic Kidney Disease Without Cardiovascular Diseases: A NHANES-Based Study.","authors":"Kejia Li, Yang Xia, Xian Sun, Bairu Shi, Jiajun Wu","doi":"10.2147/JMDH.S537988","DOIUrl":"10.2147/JMDH.S537988","url":null,"abstract":"<p><strong>Purpose: </strong>A plant-based diet (PBD) has been demonstrated to reduce the risk of chronic kidney disease (CKD) and cardiovascular diseases (CVD). This study aimed to examine the associations of PBD indices with all-cause and CVD mortality in a cohort of community-dwelling adults with predominantly early-stage CKD and no comorbid CVD.</p><p><strong>Methods: </strong>Adult CKD patients, defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m² and/or urinary albumin-to-creatinine ratio (uACR) >30mg/g, without known CVD, were included from the 1999-2018 National Health and Nutrition Examination Survey. The primary exposures were scores from the healthy PBD index (hPDI), unhealthy PBD index (uPDI), and total PDI. The Cox proportional hazards model was used for survival analysis.</p><p><strong>Results: </strong>A total of 4098 participants (mean age 55.50 years, mean eGFR 80.62 mL/min/1.73m²) were included. During a median follow-up time of 102 months, 1191 (19.52%) participants died, of which 397 were from CVD mortality. Neither the total PDI nor the hPDI was associated with all-cause or CVD mortality. The hazard ratios and 95% confidence intervals for the association between uPDI and all-cause or CVD mortality were 1.02 (1.01-1.04) and 1.01 (0.98-1.04), respectively. Restricted cubic spline analysis indicated a linearly positive relationship between uPDI and all-cause mortality. Subgroup analysis revealed that the associations between uPDI and all-cause mortality were stronger in women and non-diabetic individuals compared to men and diabetic individuals.</p><p><strong>Conclusion: </strong>Adherence to unhealthy PBD is associated with increased all-cause mortality in US CKD individuals without CVD, especially women and non-diabetic individuals.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5759-5770"},"PeriodicalIF":2.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Multidisciplinary Team-Based Cardiopulmonary Rehabilitation in Improving Outcomes for Patients with Intensive Care Unit-Acquired Weakness: A Retrospective Cohort Study.","authors":"Shaohua Cui, Shengwei Zhang, Huijuan Ren, Yu Zhang, Lixia Geng","doi":"10.2147/JMDH.S537603","DOIUrl":"10.2147/JMDH.S537603","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the impact of cardiopulmonary rehabilitation delivered through a multidisciplinary team (MDT) model on therapeutic outcomes in individuals diagnosed with intensive care unit-acquired weakness (ICU-AW).</p><p><strong>Methods: </strong>In this retrospective cohort study conducted at The First Affiliated Hospital of Baotou Medical College (Inner Mongolia, China) between January 1, 2023, and December 30, 2024, 98 patients with ICU-AW were assigned to either a control group (standard rehabilitation, n = 49) or an observation group (MDT-based rehabilitation, n = 49). Outcomes were compared using independent samples t-tests and chi-square tests (SPSS version 21.0).</p><p><strong>Results: </strong>The observation group showed significantly shorter median hospital stay (14 vs 21 days, <i>p</i> < 0.01), ICU stay (8 vs 12 days, <i>p</i> < 0.01), and mechanical ventilation duration (4 vs 7 days, <i>p</i> < 0.01) compared to controls. MRC scores improved earlier in the observation group (Day 4: 38 ± 6 vs 32 ± 5, <i>p</i> < 0.001; Day 7: 45 ± 7 vs 39 ± 6, <i>p</i> < 0.001). The overall effective rate was 83.7% in the observation group versus 61.2% in the control group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>MDT-based cardiopulmonary rehabilitation accelerates recovery, reduces healthcare resource utilization, and enhances patient satisfaction in ICU-AW. These findings support its integration into critical care pathways. Future studies should explore long-term functional outcomes and cost-effectiveness.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5729-5741"},"PeriodicalIF":2.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Influences Maternal Stress in The NICU Among Mothers of Preterm Infants?","authors":"Halyna Pavlyshyn, Iryna Sarapuk","doi":"10.2147/JMDH.S543911","DOIUrl":"10.2147/JMDH.S543911","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the levels of stress and anxiety in mothers of preterm infants across various gestational ages (GA) and identify GA-specific factors contributing to maternal stress.</p><p><strong>Patients and methods: </strong>Stress and worry were measured in 146 mothers of infants ≤32 weeks GA and 101 mothers >32 weeks GA using the Parental Stressor Scale: Neonatal Intensive Care Unit (PSS: NICU) and Worry Index (WI) questionnaires. PSS: NICU questions were distributed across the following subscales: Sights and Sounds (subscale1 (S1), Infant Appearance and Behavior (S2), and Parental Role Alteration (S3).</p><p><strong>Results: </strong>Mothers of infants ≤32 weeks GA had higher total PSS: NICU and WI scores than those >32 weeks' GA (p=0.005 and p=0.023, respectively). S3 was the most stressful subscale in both groups, followed by S2. The factors associated with higher stress in mothers of extremely/very preterm infants: seizures (p=0.022 for total PSS:NICU, p=0.030 for S2, and p=0.008 for S3), infection (p=0.045 for total PSS:NICU, p=0.039 for S2), depression (p=0.049 for total PSS:NICU), cesarean section (p=0.024 for S3), and twins (p=0.048 for S3). Higher WI was associated with lower education and C-section (p=0.038 and p=0.000, respectively). The factors associated with higher stress in the mothers of moderate/late preterm neonates: unemployment (p=0.043 for S3), vaginal delivery (p=0.035 for total PSS:NICU, p=0.048 for S3), and older children (p=0.042 for S3). Higher WI was associated with lower educational level (p=0.036), unemployment (p=0.035), depression (p=0.039), and seizures (p=0.021).</p><p><strong>Conclusion: </strong>NICU-related stress and WI levels were higher in mothers of infants with GA ≤32 weeks and were correlated with GA. In extremely/very preterm infants, higher maternal stress was linked to seizures, infection, C-section, twins, low education, and maternal depression. In moderate/late preterm neonates, stress was associated with unemployment, vaginal delivery, and having older children. Parental role alteration was the main stressor in all groups.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5713-5728"},"PeriodicalIF":2.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice Toward Breast Reconstruction Among Breast Surgery Healthcare Professionals in China.","authors":"Qiong Duan, Mingyu Sun, Desheng Kong, Jun Liu, Bo Liu, Kelin Li","doi":"10.2147/JMDH.S534905","DOIUrl":"10.2147/JMDH.S534905","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the knowledge, attitude, and practice (KAP) of breast surgery healthcare professionals in China towards breast reconstruction.</p><p><strong>Patients and methods: </strong>This multicenter cross-sectional study was performed between July and September 2024, recruiting breast surgery healthcare professionals across China. Data were collected using a self-administered questionnaire with high reliability (Cronbach's α = 0.915) to capture demographic and KAP information. Multivariate logistic analyses identified factors independently associated with the KAP.</p><p><strong>Results: </strong>A total of 371 participants were enrolled. The mean knowledge, attitude, and practice scores were 8.25±3.67, 43.77±6.25, and 25.56±4.77. Working at a teaching hospital (OR=7.019, 95% CI: 2.519-19.562, P<0.001) and performing or participating in breast reconstruction surgery for patients (OR=4.128, 95% CI: 2.170-7.853, P<0.001) were independently associated with adequate knowledge. The knowledge scores (OR=1.093, 95% CI: 1.019-1.173, P=0.013), female gender (OR=3.774, 95% CI: 1.959-7.279, P<0.001), master's degree or above education (OR=5.597, 95% CI: 2.050-15.284, P=0.001), non-public tertiary hospitals (OR=8.196, 95% CI: 2.368-28.363, P=0.001), >20 years of experience (OR=11.249, 95% CI: 1.554-81.443, P=0.017), teaching hospital (OR=3.367, 95% CI: 1.262-8.980, P=0.015), and performed or participated in breast reconstruction surgery for patients (OR=2.228, 95% CI: 1.041-4.769, P=0.039) were independently associated with the positive attitude. The knowledge scores (OR=1.176, 95% CI: 1.095-1.262, P<0.001), doctor (OR=3.502, 95% CI: 1.025-11.971, P=0.046), master's degree or above education (OR=0.116, 95% CI: 0.043-0.313, P<0.001), junior title (OR=0.194, 95% CI: 0.052-0.730, P=0.015), non-public tertiary hospitals (OR=0.225, 95% CI: 0.078-0.650, P=0.006), and 10-20 years of experience (OR=0.318, 95% CI: 0.109-0.924, P=0.035) were independently associated with the proactive practice. Structural equation modeling showed that knowledge significantly influenced both attitudes (β=-1.753, P<0.001) and practices (β=1.981, P<0.001).</p><p><strong>Conclusion: </strong>While attitudes and practices were generally positive, significant gaps remain in routine recommendation and education practices. Targeted educational programs may enhance their knowledge and improve clinical practices.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5701-5712"},"PeriodicalIF":2.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers and Emerging Trends in Edaravone Research: A Bibliometric Analysis of Molecular Basis and Clinical Studies Using CiteSpace and VOSviewer.","authors":"Li-Chao-Yue Sun, Wen-Shu Li, Wei Chen, Dan-Qi Zhao, Xin Zhang, Chun-Xing Li, Zhao Ren","doi":"10.2147/JMDH.S544626","DOIUrl":"10.2147/JMDH.S544626","url":null,"abstract":"<p><strong>Purpose: </strong>Edaravone is a potent free-radical scavenger and antioxidant that has been widely investigated for its therapeutic potential in neurodegenerative diseases and oxidative stress-related conditions. Although previous studies have explored its molecular structure, pharmacological effects, and clinical applications, a comprehensive bibliometric analysis of its research trends and future directions remains lacking.</p><p><strong>Methods: </strong>This study employed bibliometric methods to analyze edaravone-related publications from 2000 to 2024, using the Web of Science Core Collection database. The analysis examined publication trends; contributions by countries, institutions, and authors; and keyword clustering. Data visualization tools, such as CiteSpace and VOSviewer, were utilized to identify research clusters and emerging trends in edaravone research.</p><p><strong>Results: </strong>The findings revealed a significant increase in edaravone-related publications, with China, Japan, and the United States as the leading contributors. Notable researchers, including Abe K and Yoshino H, have made substantial contributions to this field. Four major research clusters were identified: free radical scavenging, cerebral infarction, amyotrophic lateral sclerosis, and oxidative stress. Emerging trends suggest a growing interest in edaravone dexbornel for acute ischemic stroke treatment, as well as its potential applications in blood-brain barrier interactions and Alzheimer's disease.</p><p><strong>Conclusion: </strong>This bibliometric analysis highlights the growing interest in edaravone and its potential clinical application, particularly in neuroprotection. While this study provides valuable insights into current research trends, future studies should incorporate a broader range of sources and languages to obtain a more comprehensive understanding of the impact and scope of edaravone.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5743-5758"},"PeriodicalIF":2.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}