Journal of Multidisciplinary Healthcare最新文献

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Association Between Depressive Symptoms and Blood Biomarkers in Adult Hospitalized Patients: A Multicenter Analysis Across Hospital Districts in Luzhou, China. 成人住院患者抑郁症状与血液生物标志物的关系:泸州医院区多中心分析
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S534823
Rongfang He, Xia Lan, Juan Chen, Shasha Hu, Zhen Zeng, Xin Xie
{"title":"Association Between Depressive Symptoms and Blood Biomarkers in Adult Hospitalized Patients: A Multicenter Analysis Across Hospital Districts in Luzhou, China.","authors":"Rongfang He, Xia Lan, Juan Chen, Shasha Hu, Zhen Zeng, Xin Xie","doi":"10.2147/JMDH.S534823","DOIUrl":"10.2147/JMDH.S534823","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the depressive symptoms of patients hospitalized in different hospitals and to further analyze the correlation between depressive symptoms and blood biomarker.</p><p><strong>Methods: </strong>This is a large-scale, multicenter cross-sectional study conducted in Luzhou, China. A total of 149554 inpatients from January 2022 to December 2023 in our hospital's Wellness Center Hospital District, Zhongshan Hospital District, and Comprehensive Ward were selected for the study. <i>t</i>-test, chi-square test and Pearson correlation analysis were used to explore associations between depressive symptoms and blood biomarker, age and gender.</p><p><strong>Results: </strong>The levels of depressive symptoms were 8.25 for patients in the Zhongshan Campus, 8.45 in the Health Center Campus, and 8.05 in the Other Campuses. In terms of blood biomarker, we found a positive correlation between depressive symptoms and lactate dehydrogenase (LDH) levels (r = 0.425, P < 0.01). In addition, thyrotropin (TSH) levels were also positively correlated with depressive symptoms (r = 0.352, P = 0.024). Regarding gender, the depressive symptoms were slightly higher in female patients (11.25) than in male patients (8.35%), but this difference was not statistically significant (P = 0.053). Age was positively correlated with depressive symptoms, with younger patients having a relatively better psychological state, whereas the prevalence of depressive symptoms increased with age, especially in the older age groups.</p><p><strong>Conclusion: </strong>There were significant differences in the prevalence of depressive symptoms among hospitalized patients in different hospital districts, and depressive symptoms showed correlation with a variety of blood biomarker. More systematic psychological assessment and intervention should be conducted for high-risk patients, especially elderly female patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5691-5699"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Preliminary Evaluation of a Structured Narrative Nursing Log for Conscious Patients in the Intensive Care Unit. 重症监护病房有意识病人结构化叙事护理日志的开发与初步评价。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S531771
Hong-Mei Liu, Jing-Yi Jin, Jian-Hong Ji, Yun Zhang, Zhi-Ming Cui
{"title":"Development and Preliminary Evaluation of a Structured Narrative Nursing Log for Conscious Patients in the Intensive Care Unit.","authors":"Hong-Mei Liu, Jing-Yi Jin, Jian-Hong Ji, Yun Zhang, Zhi-Ming Cui","doi":"10.2147/JMDH.S531771","DOIUrl":"10.2147/JMDH.S531771","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a structured narrative nursing log, grounded in narrative nursing theory, for use with conscious patients in the intensive care unit (ICU), and to conduct a preliminary clinical evaluation of its effectiveness.</p><p><strong>Methods: </strong>A structured narrative nursing log was developed through literature review, group brainstorming, and expert consultation. A quasi-experimental design was adopted. The study included 90 conscious ICU patients from a Class III Grade A hospital in Nantong, Jiangsu Province, selected via convenience sampling. Participants were assigned to either the control group (n = 46), in which nurses documented care using a blank nursing log, or the intervention group (n = 44), in which nurses utilized the structured narrative nursing log developed in this study. Primary outcome measures included patient-reported anxiety levels, perceived caring, time spent by ICU nurses on narrative nursing, and nurses' sense of professional fulfillment.</p><p><strong>Results: </strong>Patients in the intervention group exhibited significantly lower anxiety levels and significantly higher perceived caring compared to those in the control group (<i>p</i> < 0.05; 95% CI, 2.33-3.72). The average time spent on narrative nursing was also significantly lower in the intervention group (25.05 ± 1.94 minutes) than in the control group (34.07 ± 3.93 minutes) (<i>p</i> < 0.05; 95% CI, 7.71-10.33). Among the 43 participating ICU nurses, a statistically significant increase in self-reported professional fulfillment was observed following implementation of the structured log (<i>p</i> < 0.05; 95% CI, -10.95 to -6.40).</p><p><strong>Conclusion: </strong>The structured narrative nursing log shows promise in reducing anxiety-related symptoms, improving patients' perception of care, and enhancing nurses' sense of professional accomplishment. These findings suggest its potential value in refining nursing practices for conscious patients in intensive care settings.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5677-5689"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Attitudes, and Practices of Orthopedic Surgical Healthcare Professionals Regarding Perioperative Anesthetic Management Under the Enhanced Recovery After Surgery (ERAS) Concept. 加强术后恢复(ERAS)概念下骨科医疗保健专业人员关于围手术期麻醉管理的知识、态度和实践。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S543832
Xiaomin Yue, Wenzhi Guo, Jianjun Chang, Lizhi Li, Jianjun Zhao, Yong Fan, Yajuan Lei
{"title":"Knowledge, Attitudes, and Practices of Orthopedic Surgical Healthcare Professionals Regarding Perioperative Anesthetic Management Under the Enhanced Recovery After Surgery (ERAS) Concept.","authors":"Xiaomin Yue, Wenzhi Guo, Jianjun Chang, Lizhi Li, Jianjun Zhao, Yong Fan, Yajuan Lei","doi":"10.2147/JMDH.S543832","DOIUrl":"10.2147/JMDH.S543832","url":null,"abstract":"<p><strong>Objective: </strong>Enhanced recovery after surgery (ERAS) has been popularized in clinical settings, and perioperative anesthetic management under the ERAS concept in orthopedic surgery is increasingly emphasized. This study aimed to assess the knowledge, attitudes, and practices (KAP) of orthopedic surgical healthcare professionals regarding perioperative anesthetic management.</p><p><strong>Methods: </strong>This cross-sectional study included orthopedic surgical healthcare professionals at four hospitals between January and December 2023. A self-administered questionnaire was developed to collect participants' socio-demographic information and KAP scores. Structural equation modeling (SEM) was applied to assess direct and indirect associations among KAP dimensions.</p><p><strong>Results: </strong>Totally, 386 participants were included, with a mean age of 36.17±8.34 years. The KAP scores were 23.23±5.88 (possible range: 0-30), 46.99±4.38 (possible range: 11-55), and 33.13±7.46 (possible range: 9-45), respectively. Multivariate logistic analysis revealed that age, employment in the anesthesiology department, ERAS training experience within the past year, and number of orthopedic surgeries in the past year were independently associated with good knowledge. Knowledge score, master's degree or above, and work experience were independently associated with a positive attitude. Knowledge score, attitude score, and employment in the anesthesiology department were independently associated with proactive practice. SEM further indicated positive associations between knowledge and attitude (β=0.29, P<0.001), between knowledge and practice (β=0.54, P<0.001), and between attitude and practice (β=0.30, P<0.001).</p><p><strong>Conclusion: </strong>Orthopedic surgical healthcare professionals showed a positive attitude, while their knowledge and practice of perioperative anesthetic management remained at a moderate level. Educational and behavioral interventions are recommended for those with young age, shorter work experience, less surgical caseload, and lower educational levels.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5651-5662"},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceived Needs and Barriers in Raising a Child with ASD and Accessing Early Interventions in Qatar: Parents' Voices. 感知需求和障碍在养育自闭症儿童和获得早期干预在卡塔尔:父母的声音。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S525521
Lara M Saranek, Mujahed Shraim, Nazim Abdel Aati, Ghadir Fakhri Al-Jayyousi
{"title":"Perceived Needs and Barriers in Raising a Child with ASD and Accessing Early Interventions in Qatar: Parents' Voices.","authors":"Lara M Saranek, Mujahed Shraim, Nazim Abdel Aati, Ghadir Fakhri Al-Jayyousi","doi":"10.2147/JMDH.S525521","DOIUrl":"10.2147/JMDH.S525521","url":null,"abstract":"<p><strong>Background: </strong>Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental disorder that is often associated with mental health comorbidities. Parents are challenged with raising a child diagnosed with ASD. However, research about parental challenges in Arab countries is limited. The study aims to explore parents' experiences of raising a child with ASD and accessing early interventions provided for their children in Qatar.</p><p><strong>Methods: </strong>An inductive qualitative study design was applied. Data was collected using face-to-face interviews with parents (n=20). Interviews were transcribed verbatim, and thematic analysis was employed.</p><p><strong>Results: </strong>The main elicited themes from the analysis were mainly about: challenges of raising a child diagnosed with ASD; parents' perception of existing ASD services; parents' perception of mental health services for children diagnosed with ASD; parents' perception of the impact of the COVID-19 pandemic on ASD services; and the impact of raising a child diagnosed with ASD on parents.</p><p><strong>Conclusion: </strong>Parents face challenges with raising a child diagnosed with ASD and with accessing ASD early intervention services for their children. The findings guide health care professionals working with children with ASD and their families, and policy makers in developing standards of care for ASD service in the governmental facilities in Qatar.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5663-5676"},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bibliometric Analysis of Chinese Medicine for Allergic Rhinitis. 中药治疗变应性鼻炎的文献计量分析。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S549146
Zheng-Fan Wang, Jun Xiong, Yong-Qi Du, Shuang Yang, Hai-Yan Xu
{"title":"A Bibliometric Analysis of Chinese Medicine for Allergic Rhinitis.","authors":"Zheng-Fan Wang, Jun Xiong, Yong-Qi Du, Shuang Yang, Hai-Yan Xu","doi":"10.2147/JMDH.S549146","DOIUrl":"10.2147/JMDH.S549146","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess the current research status of Chinese medicine research on treating allergic rhinitis (AR) using bibliometric methods, and to explore research hotspots and pinpoint future trends in this field.</p><p><strong>Methods: </strong>Articles concerning Chinese medicine for AR in Web of Science Core Collection databases were searched from January 1, 2004, to May 31, 2024. VOSviewer 1.6.20 and CiteSpace 6.3.R1 software were used to conduct descriptive analysis, including publications, authors, countries, institutions, journals, cited journals, cited authors, cited references, and keywords from various angles.</p><p><strong>Results: </strong>A total of 221 publications were included. Paper production has increased over the past 20 years, despite fluctuations. The most productive country is China, whose Chengdu University of Traditional Chinese Medicine is the institution with the highest number of papers. Germany's Brinkhaus, Benno has the most papers in the discipline, while Bousquet J is the most influential author. Medicine is a journal that has the most research on Chinese medicine for treating AR, while Allergy has the most citations. The most frequently cited reference is a guideline concerning the diagnosis and treatment of AR. The most common keywords are allergic rhinitis, asthma, effect, prevalence, and Chinese herbal medicine.</p><p><strong>Conclusion: </strong>This study assessed the research status of Chinese medicine for AR via bibliometric approaches from 2004 to 2024, which may be useful for researchers to identify hotspots and frontier trends in this field.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5603-5620"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Reduction of Hypoglycemia Incidence Post-Endoscopic Polypectomy Through Quality Control Circle Implementation. 通过质控圈的实施持续降低内镜息肉切除术后低血糖的发生率。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S524337
Shan Yuan, Bingjing Yu, Lingyun Song, Linping Chen, Fenfen Hong
{"title":"Continuous Reduction of Hypoglycemia Incidence Post-Endoscopic Polypectomy Through Quality Control Circle Implementation.","authors":"Shan Yuan, Bingjing Yu, Lingyun Song, Linping Chen, Fenfen Hong","doi":"10.2147/JMDH.S524337","DOIUrl":"10.2147/JMDH.S524337","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to reduce the incidence of hypoglycemia following endoscopic polypectomy by implementing Quality Control Circle (QCC) interventions.</p><p><strong>Methods: </strong>Quality Control Circle (QCC) empowered clinicians to implement PDCA-driven protocol refinements, standardizing care processes to mitigate hypoglycemia risk. Establish a QCC team to investigate the current incidence of hypoglycemia in post-polypectomy patients, conduct a root cause analysis to identify the true causes, formulate corresponding countermeasures, and implement them in phases. The study was conducted in two phases: before-QCC (517 patients from March 13 to May 31, 2023) and after-QCC (1090 patients from June 1 to November 30, 2023). The primary outcome was the incidence of hypoglycemia.</p><p><strong>Results: </strong>Before QCC implementation, the incidence of hypoglycemia was 6.63%. Following the introduction of QCC interventions, the incidence significantly decreased to 2.94% (<i>p</i><0.01). Monthly data revealed a continuous decline in hypoglycemia incidence, with rates dropping from 4.12% in June to 1.47% in November, and the results are statistically significant (<i>p</i><0.001). Other confounding factors, including age, gender, education level, diabetes history, polyp size, site, and fasting duration, were not significantly associated with the outcome (<i>p</i>>0.05).</p><p><strong>Conclusion: </strong>This study effectively reduced the incidence of hypoglycemia in patients following endoscopic polypectomy through the implementation of QCC activities, significantly enhancing patient safety and treatment outcomes. The successful implementation of the project validated the important role of QCC in continuous quality improvement, providing valuable experience and methods for future clinical nursing management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5621-5634"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Readiness for Hospital Discharge Among Patients with T-Tubes: A Review of Influencing Factors and Interventions. t管患者出院准备:影响因素及干预措施综述
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S543372
Xiaojuan Zhou, Shuai Huang, Jiani Gu
{"title":"Readiness for Hospital Discharge Among Patients with T-Tubes: A Review of Influencing Factors and Interventions.","authors":"Xiaojuan Zhou, Shuai Huang, Jiani Gu","doi":"10.2147/JMDH.S543372","DOIUrl":"10.2147/JMDH.S543372","url":null,"abstract":"<p><strong>Objective: </strong>This review aimed to summarizes existing research on readiness for hospital discharge among patients discharged with T-tubes, with a focus on assessment tools, influencing factors, and intervention strategies, to establish a theoretical foundation for improving discharge preparation in this population.</p><p><strong>Methods: </strong>A structured literature review was conducted to identify and synthesize studies examining determinants of discharge readiness in patients with drainage tubes, particularly T-tubes.</p><p><strong>Results: </strong>Multiple factors were found to influence readiness for hospital discharge among patients with T-tubes, including age, living conditions, educational background, and the clarity and comprehensiveness of discharge instructions. In addition, external elements such as the availability of social support significantly impacted discharge readiness.</p><p><strong>Conclusion: </strong>Discharge preparation for patients with T-tubes remains suboptimal in current clinical practice. Future research should prioritize the identification of key influencing factors and the development of individualized discharge plans or decision-support protocols to promote smooth transitions from hospital to home, reduce unplanned readmissions, and improve both patient-reported outcomes and health-related quality of life.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5581-5590"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Cardiometabolic Index and Post-PCI Coronary Microvascular Dysfunction in Acute STEMI Patients. 急性STEMI患者心脏代谢指数与pci术后冠状动脉微血管功能障碍的关系
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S549547
Xiang Sha, Wei Wang, Jian Wang, Ruzhu Wang
{"title":"Relationship Between Cardiometabolic Index and Post-PCI Coronary Microvascular Dysfunction in Acute STEMI Patients.","authors":"Xiang Sha, Wei Wang, Jian Wang, Ruzhu Wang","doi":"10.2147/JMDH.S549547","DOIUrl":"10.2147/JMDH.S549547","url":null,"abstract":"<p><strong>Background: </strong>Coronary microvascular dysfunction (CMD) significantly impacts outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). The cardiometabolic index (CMI), an indicator combining lipid and anthropometric parameters, has been linked to cardiovascular risk, but its association with CMD remains unclear. This study aims to investigate the relationship between CMI and the occurrence of CMD following PCI in STEMI patients and to assess its predictive value using Least Absolute Shrinkage and Selection Operator (LASSO)-based feature selection and multiple machine learning algorithms.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled STEMI patients who underwent primary PCI with stent implantation and post-procedural coronary microvascular function assessment between January 2021 and December 2024. Patients were categorized into CMD and non-CMD groups based on noninvasive microvascular resistance indices. Logistic regression, restricted cubic spline analysis, and machine learning models (Random Forest (RF), LightGBM, XGboost and K-Nearest Neighbors) were employed to evaluate the predictive value of CMI for post-PCI CMD.</p><p><strong>Results: </strong>A total of 702 STEMI patients were included, and CMD was observed in 52.1% of patients. Compared to the first CMI tertile (T1) group, T2 and T3 group had increased odds of CMD (T2: adjusted odds ratio (aOR) 2.41, 95% confidence interval (CI) 1.60-3.63; T3: aOR 3.40, 95% CI 2.17-5.32). There was a non-linear relationship between CMI and CMD (<i>P</i> < 0.001). The area under the curve (AUC) for CMI predicting CMD was 0.627 (95% CI: 0.586-0.666). Seven variables were screened by LASSO-Logistic regression for model development. Comparing four models' performances, the RF model achieved the best performance (AUC = 0.772). SHapley analysis revealed that CMI had the highest predictive value for CMD.</p><p><strong>Conclusion: </strong>A higher CMI level is an independent risk factor for CMD of STEMI patients after PCI, and its predictive value enhanced when integrated into RF model.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5591-5602"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Lipid a Missing Link Between Renal Function and Diabetes Risk? Insights from a Mediation Analysis Based on the Cohort Study. 血脂是肾功能与糖尿病风险之间缺失的一环吗?基于队列研究的中介分析的启示。
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S544229
Xiaomin Liang, Haofei Hu, Ying Li, Shuiqing Gui
{"title":"Is Lipid a Missing Link Between Renal Function and Diabetes Risk? Insights from a Mediation Analysis Based on the Cohort Study.","authors":"Xiaomin Liang, Haofei Hu, Ying Li, Shuiqing Gui","doi":"10.2147/JMDH.S544229","DOIUrl":"10.2147/JMDH.S544229","url":null,"abstract":"<p><strong>Purpose: </strong>Both renal function impairment and lipid abnormalities are recognized risk factors for diabetes. However, the potential mediating role of lipid parameters in the relationship between renal function and diabetes risk remains unexplored. This study aimed to investigate whether and to what extent lipid parameters mediate the association between renal function and diabetes risk.</p><p><strong>Patients and methods: </strong>We conducted a cohort study including adults from 32 sites across 11 Chinese cities between 2010 and 2016. Renal function was assessed by estimated glomerular filtration rate (eGFR). Lipid parameters included triglyceride glucose (TyG), triglyceride glucose- body mass index (TyG-BMI), triglyceride/ high-density lipoprotein cholesterol (TG/HDL-c), and atherogenic index of plasma (AIP). Cox proportional hazards models were used to examine the relationship between eGFR and diabetes risk. Subgroup analyses were performed to identify potential effect modifiers. Mediation analyses quantified the proportion of eGFR's effect on diabetes risk mediated through each lipid parameter.</p><p><strong>Results: </strong>Among 115,488 participants (54.07% male, mean age 44.12 ± 12.95 years) followed for 3.10 ± 0.95 years, 2659 (2.30%) developed diabetes. After multivariable adjustment, higher eGFR was inversely associated with diabetes risk (HR=0.98, 95% CI: 0.98-0.98). This association was more pronounced in females, participants <60 years, those with BMI <25 kg/m², SBP <140 mmHg, non-smokers, non-drinkers, ALT <40 U/L, and AST <40 U/L. Mediation analyses revealed that TyG, TyG-BMI, TG/HDL-c, and AIP mediated 23.14%, 21.05%, 3.54%, and 12.49% of the eGFR-diabetes relationship, respectively.</p><p><strong>Conclusion: </strong>Reduced renal function, as indicated by lower eGFR, is associated with increased diabetes risk. This relationship is partially mediated through lipid metabolism pathways, suggesting lipid may represent a missing link between renal function and diabetes risk.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5635-5649"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Summary of the Best Evidence for the Prevention and Management of Medical Adhesive-Related Skin Injuries in Patients with Tracheal Intubation. 预防和处理气管插管患者医用胶粘剂相关皮肤损伤的最佳证据综述
IF 2.4 3区 医学
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-06 eCollection Date: 2025-01-01 DOI: 10.2147/JMDH.S529677
Minhua Hu, Jiajia Hu, Peng Sun, Hongyan Zheng, Mingyang Zhang
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