Journal of Multidisciplinary Healthcare最新文献

{"title":"Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review.","authors":"Siti Rissaadah, Nursiswati Nursiswati, Tuti Pahria","doi":"10.2147/JMDH.S510247","DOIUrl":"10.2147/JMDH.S510247","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM), characterized by chronic hyperglycemia, leads to a decreased immune system and increased susceptibility to infections, such as tuberculosis (TB). However, there are gaps in comprehensive reviews on the relationship between TB and the severity of glycemic control in patients with T2DM, characteristics of glycemic levels, and clinical treatment among patients with DM-TB.</p><p><strong>Purpose: </strong>The primary aim of this study is to explore the association of DM-TB and glycemic control. The secondary aim of this study was to explore the association between DM-TB, successful treatment, and TB severity.</p><p><strong>Methods: </strong>This study used a scoping review following the Arksey and O'Malley framework to provide an overview of glycemic control and clinical treatment of DM-TB. A literature search was performed using three databases, PubMed, Scopus, and Medline, with inclusion criteria for the population of patients with diabetes mellitus and tuberculosis who discuss glycemic control and clinical treatment. Critical appraisal in this study was assessed using the Joanna-Briggs Institute (JBI) critical appraisal tools.</p><p><strong>Results: </strong>We included 16 studies from a total of 741 articles in the initial search. The results of this study showed that patients with DM-TB were more likely to have poor glycemic control than those with diabetes mellitus (DM) without TB. Severe hyperglycemia in patients with DM-TB is associated with an increased risk of TB treatment failure, a long recovery time, and the likelihood of developing multi-drug-resistant tuberculosis (MDR-TB). In addition, patients with DM-TB who did not start TB treatment were more likely to have poorer glycemic control than patients with DM-TB who underwent active TB treatment.</p><p><strong>Conclusion: </strong>Patients with DM-TB, such as MDR-TB, are at a higher risk of poor glycemic control, treatment failure, and clinical severity. Adequate treatment, such as a continuum of glycemic monitoring and early detection and intervention for TB, is needed to improve treatment outcomes.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"747-758"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Maternal Needs for \"Internet+ Nursing Service\" After Hospital Discharge: A SERVQUAL-KANO Model Approach.","authors":"Lei Ding, Yajie Ding, Yiting Wang, Xianwen Li, Ying Liu","doi":"10.2147/JMDH.S505926","DOIUrl":"10.2147/JMDH.S505926","url":null,"abstract":"<p><strong>Purpose: </strong>The provision of postnatal continuity of care is of significant importance to new mothers. Given the prevalence of \"Internet+ Nursing Services\", there has been a paucity of research exploring the internet-based home care needs of mothers following their discharge from hospital. This study employs a combination of the SERVQUAL and KANO models to investigate maternal requirements for Internet+ nursing services and to establish a foundation for enhancing the quality of postnatal nursing services.</p><p><strong>Patients and methods: </strong>A questionnaire was designed by combining SERVQUAL and KANO models, and a cross-sectional survey was conducted in the obstetrics department of a tertiary hospital in China after expert correspondence. The survey targeted 279 mothers about to be discharged after delivery, aiming to explore their demand for Internet+ nursing services post-discharge. Data were analyzed according to the KANO model.</p><p><strong>Results: </strong>The better values (satisfaction coefficient) of Internet+ nursing services ranged from 42.91% to 78.46%, while the worse values (dissatisfaction coefficient) were 28.91% to 63.20%. The must-be and one-dimensional need attributes of maternity are mainly tangibility, reliability, responsiveness, and assurance dimensions, and empathy and economy are attractive attributes. Two items within the tangibles dimension, namely ease of operation of the platform and nurses' dress code, were deemed to be indifferent attributes. In the quadrant analysis diagram, the attributes of must-be, one-dimensional, attractive, and indifferent were 8(33.3%), 66(25.0%), 8(33.3%), and 2(8.3%), respectively.</p><p><strong>Conclusion: </strong>Attributes of Chinese mothers' needs for Internet+ nursing services after hospital discharge were defined, ranked, and categorized by the KANO model, providing a theoretical basis for the targeted design and improvement of care services. It is suggested that care managers consolidate must-be attributes and one-dimensional attributes, optimize attractive attributes, and transform indifferent attributes to better meet the multifaceted service needs of mothers.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"721-734"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Group O Washed Red Blood Cell Transfusion on Vital Signs and Hematologic Stability in Trauma Patients With Different Blood Types.","authors":"Xian-Juan Gou, Lin-Fei Li, Xiao-Li He, Xi Chen, An-Yong Yu, Wei-Yan Tian","doi":"10.2147/JMDH.S500906","DOIUrl":"10.2147/JMDH.S500906","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively assess the impact of emergency transfusion of group O washed red blood cells on the vital signs and hematological parameters of patients with severe trauma and to analyze the differential responses among different blood types, thereby providing valuable evidence for optimizing transfusion strategies.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of patients with severe trauma who underwent emergency transfusion in the hospital's emergency department from April 2023 to March 2024. Changes in blood biochemical indexes and vital signs before and after transfusion were compared, and adverse transfusion reactions were monitored.</p><p><strong>Results: </strong>A total of 65 patients were included in the study, and no adverse transfusion reactions were observed. The shock index (SI) score was 1.07 ± 0.28. Significant changes were noted in platelet count (PLT), activated partial thromboplastin time (APTT), and C-reactive protein (CRP) following transfusion (<i>P</i> < 0.05). Both blood pressure and SI enhanced significantly after transfusion (<i>P</i> < 0.05), although no significant change in heart rate (HR) was detected (<i>P</i> = 0.87). Patients with blood group A experienced a significant reduction in HR post-transfusion. In patients with blood groups AB or O, systolic blood pressure (SBP) significantly increased, and SI significantly decreased. Additionally, patients with blood group O revealed a significant rise in diastolic blood pressure (DBP) post-transfusion, with the differences being statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Timely and effective transfusion of group O washed red blood cells is crucial for stabilizing the vital signs of patients with severe trauma. This approach is not only safe but also feasible, with blood type influencing the response to transfusion. Larger, multi-center studies are warranted to further validate these findings and enhance the generalizability.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"711-719"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia.","authors":"Abdullah A Alharbi, Nawfal A Aljerian, Hani A Alghamdi, Meshary S Binhotan, Ali K Alsultan, Mohammed S Arafat, Abdulrahman Aldhabib, Ahmed I Aloqayli, Eid B Alwahbi, Ronnie D Horner","doi":"10.2147/JMDH.S493246","DOIUrl":"10.2147/JMDH.S493246","url":null,"abstract":"<p><strong>Background and objective: </strong>Mental disorders significantly impact quality of life and life expectancy, representing a leading cause of global disease burden. Healthcare systems worldwide face challenges in meeting mental health service demands, particularly due to specialist shortages and geographical barriers. Saudi Arabia has implemented an innovative nationwide electronic referral system (SMARC) as part of its digital health transformation strategy to enhance mental healthcare accessibility. This study examined SMARC's effectiveness in facilitating mental health service access by analyzing patient transfer acceptance rates between healthcare facilities and identifying factors influencing these rates.</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed 9722 mental health electronic referrals within SMARC from January 2020 to December 2021. Descriptive statistics characterized referral patterns, while bivariate and multivariable logistic regression analyses identified factors associated with referral acceptance, calculating adjusted odds ratios (aORs) and 95% confidence intervals.</p><p><strong>Results: </strong>The system achieved an overall acceptance rate of 82.5%, with different patterns across age groups and regions. Lower acceptance rates were observed for ages 15-25 years (aOR = 0.84; 95% CI = 0.70-0.99) and 46-65 years (aOR = 0.83; 95% CI = 0.70-0.99) compared to ages 26-35 years. Life-saving referrals showed the highest acceptance (aOR = 2.60; 95% CI = 1.51-4.48), while psychiatrist availability significantly influenced acceptance rates (aOR = 1.36; 95% CI = 1.17-1.58). External referrals were half as likely to be accepted as internal ones (aOR = 0.51; 95% CI = 0.42-0.64).</p><p><strong>Conclusion: </strong>SMARC demonstrates effectiveness in optimizing mental healthcare access through strategic matching of patient needs with available resources. The system's selective acceptance patterns reflect its capability to prioritize care based on clinical urgency and resource availability. These findings provide valuable insights for policymakers to keep enhancing digital health infrastructure and mental healthcare delivery. The SMARC model offers a promising framework for implementing similar digital referral systems globally to improve mental healthcare coordination and accessibility.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"735-745"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024.","authors":"YanJie Lian, Heyi Zhang, Wenlong Xing, Sinai Li, Xiaolei Lai, Sihan Jia, JuJu Shang, Hongxu Liu","doi":"10.2147/JMDH.S505356","DOIUrl":"10.2147/JMDH.S505356","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is characterized by elevated morbidity, mortality, and rehospitalization frequencies. This condition imposes a considerable medical burden and fiscal strain on society. Inflammation plays a crucial role in the inception, advancement, and outcome of HF. Despite mounting evidence demonstrating the pivotal function of the NLRP3 inflammasome in HF, a thorough bibliometric examination of research focal points and trajectories in this domain has yet to be undertaken.</p><p><strong>Methods: </strong>Publications related to the NLRP3 inflammasome in HF were retrieved from the Web of Science database spanning 2010-2024. The acquired data were subsequently analyzed utilizing various visualization instruments, including Citespace, VOSviewer, Scimago Graphica, and Microsoft Office Excel 2021.</p><p><strong>Results: </strong>A total of 282 papers were included in the analysis, authored by 2,130 researchers from 500 institutions across 34 nations/regions. China emerged as a significant contributor to this field, producing the highest number of outputs. Antonio Abbate was identified as the most prolific author. Virginia Commonwealth University and Wuhan University were the institutions with the highest publication output. <i>INTERNATIONAL IMMUNOPHARMACOLOGY</i> was the periodical with the most numerous publications in this sphere. <i>CIRCULATION</i>, however, received the highest number of citations, indicating its substantial influence on investigations in this field. Contemporary research focal points primarily concentrate on the activation and inhibition pathways of the NLRP3 inflammasome, the exploration of novel HF targets, and the association between HF and mitochondrial function. Future research trajectories are likely to encompass investigations into the relationship between HF and pyroptosis, as well as clinical studies on pharmaceuticals targeting the NLRP3 inflammasome as a therapeutic approach for HF.</p><p><strong>Conclusion: </strong>This investigation provides a comprehensive bibliometric analysis and synopsis of NLRP3 inflammable-related studies in HF. The findings offer a conceptual foundation for further research on the NLRP3 inflammasome in HF and provide valuable guidance for future research directions in this domain.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"697-710"},"PeriodicalIF":2.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Online Interactive Platform Services on Oral Health Behaviors in Older Adults With Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial.","authors":"Qianyu Yin, Zhaowu Chai, Binbin Tao, Ping Liu, Yu Luo, Qinghua Zhao, Bing Yang","doi":"10.2147/JMDH.S508247","DOIUrl":"10.2147/JMDH.S508247","url":null,"abstract":"<p><strong>Purpose: </strong>Older adults with mild cognitive impairment (MCI) are at a high risk for oral health decline. To address this, we designed an intervention to improve oral health behaviors specifically for elderly individuals with MCI. Here we describe the protocol for a study with the following aims: to enhance oral health behaviors through online education tailored to the cognitive load of older adults and to maintain or delay cognitive decline.</p><p><strong>Patients and methods: </strong>This randomized, parallel, single-blind controlled trial will evaluate the effectiveness of an oral health behavior intervention based on an online interactive platform (e-COM[OH]) in older adults with MCI. The participants will be randomly assigned to two groups. The intervention group will receive oral health behavior training through an online platform consisting of four modules: Games, Health Knowledge, Health Skills, and Symptom Reporting Center. The control group will follow the hospital's official account and receive general oral health education. The primary outcome will be the oral health behavior score, assessed using an oral health behavior questionnaire. The secondary outcomes will include social support, perceived stress, cognitive level, oral health-related quality of life, and oral health status. Participant enrollment will begin in April 2024 and is expected to be completed in November 2024.</p><p><strong>Conclusions: </strong>This trial will evaluate whether the e-COM(OH) WeChat mini-program is suitable to improve the oral health behaviors and cognitive functions of older adults with MCI. If its effectiveness is validated and e-COM(OH) is deemed acceptable, appropriate, and feasible, it could serve as a strategic approach to address oral health issues and prevent cognitive decline in older adults with mild cognitive impairment.</p><p><strong>Trial registration: </strong>The trial has been registered on the www.chictr.org.cn registration platform on 19 April 2024 (registration number: ChiCTR2400083250).</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"663-674"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Health Science Students' Knowledge, Attitudes, and Practices Toward Artificial Intelligence in Northern Saudi Arabia: Implications for Curriculum Refinement and Healthcare Delivery.","authors":"Bashayer Farhan ALruwail, Afrah Muteb Alshalan, Ashokkumar Thirunavukkarasu, Alaa Alibrahim, Anfal Mohammed Alenezi, Tahalil Zamil A Aldhuwayhi","doi":"10.2147/JMDH.S499902","DOIUrl":"10.2147/JMDH.S499902","url":null,"abstract":"<p><strong>Background and aim: </strong>As the integration of artificial intelligence (AI) in healthcare delivery becomes increasingly prevalent, understanding the knowledge, attitudes, and practices of health science students towards AI is crucial. However, limited evidence exists regarding the readiness of health science students, particularly in northern Saudi Arabia (KSA), to integrate AI into their future practices, highlighting the need for focused evaluation. We evaluated northern Saudi health science students' knowledge, attitude, practice, and associated factors toward AI.</p><p><strong>Participants and methods: </strong>The present cross-sectional study was conducted among 384 health science students aged 18 years and above from Jouf University, KSA. The study employed a validated data collection form with four sections: demographics, knowledge (AI principles and applications), attitudes (perceptions and ethical concerns), and practices (usage and confidence in AI tools). The three domains' scores were categorized as low (<60%), medium (60-80%) and high (>80%) based on their total scores. We utilized Spearman correlation test to ascertain the strength and direction of correlation among each subscale. Additionally, multivariate analysis was employed to identify associated factors.</p><p><strong>Results: </strong>The present study demonstrated low knowledge, attitude, and practices among 55.7%, 37.0%, and 50.3% of health science students. We observed a positive correlation between knowledge and attitude (rho = 0.451, p = 0.001), knowledge and practice (rho = 0.353, p = 0.001), and attitude and practice (rho = 0.651, p = 0.001). Knowledge (p = 0.001) and practice (p = 0.002) were significantly higher among the students who participated in a formal AI training program. Females had a significantly higher level of attitude (p = 0.001) and practice (p = 0.030) than males.</p><p><strong>Conclusion: </strong>In light of these findings, refining the curriculum to incorporate AI emerges as a critical strategy for addressing gaps in AI knowledge, attitudes, and practices among health science students. Therefore, formal and integrated training programs tailored to suit the local setting can effectively prepare health science students to adopt AI technologies in ways that enhance patient care.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"623-635"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual-Level Determinants of Self-Care Behaviors and Adaptation to Chronic Illness in Turkish Patients With Chronic Disease: A Single-Center Cross-Sectional Study.","authors":"Yasin Furkan Kılıç, Tuğba Yardımcı Gürel","doi":"10.2147/JMDH.S500065","DOIUrl":"10.2147/JMDH.S500065","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the relationship between self-care management behaviors of individuals with chronic disease and their adaptation to chronic illness.</p><p><strong>Methods: </strong>This cross-sectional and correlational study was conducted with 312 patients treated at a Training and Research Hospital in Turkey between December 2023 and March 2024. The data were collected using a Sociodemographic Characteristics Form, the Self-Care Management Scale in Chronic Illness (SCMP-G) and the Adaptation to Chronic Illness Scale (ACIS).</p><p><strong>Results: </strong>Mean total scores of the participants for SCMP-G were 107.52 ± 12.51 and 77.00 ± 10.00 for ACIS. There was a low-level negative correlation between age and chronic disease adaptation (rh = -0.201; P < 0.001). Adaptation to chronic illness decreased with increasing age. There was a low-level negative correlation between BMI and physical adaptation (rh = -0.127; P = 0.026) and self-guarding (rh = -0.114; P = 0.046). As BMI increased, physical adaptation and self-guarding decreased. Regression analyses revealed that age (β = -0.115, t = -0.511, P < 0.05) and economic status (β = 2.698, t = -2.487, P < 0.05) had a significant effect on adaptation to chronic illness. Multiple regression analysis of the effect of self-guarding and social guarding variables on adaptation to chronic illness was significant (F = 3.504, P < 0.05).</p><p><strong>Conclusion: </strong>Based on the results of the present study, self-care management behaviors have a significant effect on adaptation to chronic illness and individual characteristics affect the results. Individual assistance should be extended to the patients to develop self-care management behaviors, which can induce lifestyle changes and necessary trainings should be planned. Future research should prioritize evaluating nurse-led interdisciplinary interventions and exploring the impact of tailored strategies for specific chronic conditions to improve self-care and adaptation.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"637-650"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Expression of Peripheral Blood Leukocyte Surface Markers in Retinopathy of Prematurity Patients.","authors":"Rui Guo, Fang Cheng, Xiang-Jie Meng, Jun-Mei Fan, Ya-Ling Lu, Xiao-Hui Ma, Xin Qiao, Jun-Hong Li","doi":"10.2147/JMDH.S495761","DOIUrl":"10.2147/JMDH.S495761","url":null,"abstract":"<p><strong>Objective: </strong>Our study compares immune cell profiles in preterm infants with and without severe ROP, identifying risk factors for its development to explore both immunological aspects and determinants of ROP in preterm infants.</p><p><strong>Methods: </strong>Infants born between January 2023 to December 2023 at the Children's Hospital of Shanxi were enrolled in this study according to the inclusion criteria. Patients were divided into a test group or a control group based on the need for Type 1 ROP treatment. Baseline data for both groups were compared. Neutrophil, lymphocyte, and monocyte subsets in the peripheral blood were analyzed using immunophenotypic analysis via multicolor flow cytometry. This method allowed for the quantification of specific cell subset proportions.</p><p><strong>Results: </strong>A total of 2,110 preterm infants were screened for inclusion in the study. Multivariate logistic regression analysis identified gestational age below 28 weeks, birth weight less than 1,000 g, and neonatal sepsis as independent risk factors for severe ROP. Furthermore, flow cytometry analysis was performed on blood samples from 45 preterm patients. Comparative analysis revealed that the test group had a lower percentage of neutrophils and higher expression of cluster of differentiation 81 (CD81) compared to the control group. Additionally, the test group showed a higher percentage of lymphocytes and a greater proportion of Th17 cells than the control group.</p><p><strong>Conclusion: </strong>Preterm gestational age, low birth weight, and neonatal sepsis increase severe ROP risk. Elevated CD81 and Th17 levels suggest inflammation linked to neutrophils and lymphocytes.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"651-661"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma.","authors":"Zhi-Hong Yu, Wei-Qin Ma, Ji-Wei Ren, Xu-Ting Zhang, Lin Chu","doi":"10.2147/JMDH.S495962","DOIUrl":"10.2147/JMDH.S495962","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between computed tomography (CT) imaging characteristics and programmed death ligand-1 (PD-L1) expression in patients with gastric adenocarcinoma (GAC), and to develop a nomogram model for prediction.</p><p><strong>Methods: </strong>The patients were randomly allocated into a training set and a validation set at a ratio of 7:3. The training set was further divided into a PD-L1 positive group and a PD-L1 negative group, based on the combined positive score (CPS). Univariate and multivariate logistic regression analyses were performed to identify independent predictors of PD-L1 positivity. A nomogram was developed to assess the model's predictive performance, which was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). It was also compared with the model established by previous study.</p><p><strong>Results: </strong>Patients with PD-L1-positive gastric adenocarcinoma exhibited a higher prevalence of larger short diameters of lymph nodes (LNs) (≥ 1 cm), and lower CT attenuation values in the venous and delayed phases compared to those in the PD-L1-negative group. Short diameter of LNs, and CT attenuation values in the delayed phase were identified as independent predictors of PD-L1 positivity. The nomogram analysis indicated that CT attenuation values in the delayed phase were the most significant predictor of PD-L1 positivity, followed by short diameter of LNs.</p><p><strong>Conclusion: </strong>The GAC prediction model based on the CT imaging features is effective in predicting PD-L1 expression levels and demonstrates strong clinical applicability.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"609-621"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}