Journal of Multidisciplinary Healthcare最新文献

{"title":"Healthcare Personnel Experiences With Health Literacy Sensitivity in Relation to Work Satisfaction and Stress: A Qualitative Study.","authors":"Malene Nerbøvik Stavdal, Marie Hamilton Larsen, Astrid Klopstad Wahl, Ingeborg Strømseng Sjetne, Anners Lerdal, Caryl L Gay, Christine Råheim Borge","doi":"10.2147/JMDH.S493548","DOIUrl":"10.2147/JMDH.S493548","url":null,"abstract":"<p><strong>Objective: </strong>To qualitatively explore healthcare personnel's (HCP) experiences with health literacy sensitivity in relation to work satisfaction and stress. Being HL sensitive means that HCP have adequate knowledge, skills, and attitudes to follow up on patients' HL needs.</p><p><strong>Methods: </strong>Four focus group interviews were conducted with 30 hCP from a medium-sized general hospital in Oslo, Norway. We used inductive thematic analysis developed by Braun & Clark. NVivo v12 software assisted data analysis.</p><p><strong>Results: </strong>Three main themes were identified: (1) HCP experiences with HL (2) HCP experience barriers with HL sensitivity, and (3) HCP collaboration and communication are essential for HL. Variability in HL understanding among HCP may lead to challenges in providing patient-centered care. Factors such as heavy workloads, cultural barriers, and organizational limitations hinder HL sensitivity and can cause frustration and stress among HCP.</p><p><strong>Conclusion: </strong>Targeted interventions and organizational support are essential to address HCP's obstacles with HL sensitivity. Utilizing improved communication techniques and HL tools may help reduce stress and frustration.</p><p><strong>Practice implications: </strong>To optimize HL sensitivity, it is imperative to prioritize HCP needs. Organizations should strive to facilitate HL in a way that does not impose additional stress on HCP.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1269-1280"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of the Biomechanical Research of Pelvic Organ Prolapse: A Scientometric Approach.","authors":"Haolan Du, Miyang Yang, Xuge Qi, Lanlan Yang, Zhaochu Wang, Tao Yang, Shangwen Xu, Liyuan Fu","doi":"10.2147/JMDH.S473196","DOIUrl":"10.2147/JMDH.S473196","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse (POP) has become a significant public health issue, with its prevalence increasing proportionally with age. Despite the considerable number of biomechanical studies reported on POP, there remains a lack of a systematic approach to summarize and synthesize all existing research.</p><p><strong>Methods: </strong>The Web of Science Core Collection (WoSCC) database was used as the data source to select literature published from 2003 to 2023 related to biomechanical research of POP. We employed various visualization software to generate scientific knowledge maps, facilitating data analysis and visual representation.</p><p><strong>Results: </strong>This study included 292 publications, comprising 252 research articles (86.3%) and 40 review articles (13.7%). The United States has emerged as a leading nation in terms of productivity, with the University of Porto making significant contributions. Robust partnerships are maintained by all countries and institutions involved. Moali PA stands out as the most prolific author, while Deprest J exhibits exemplary levels of collaboration. Notably, the journal <i>Int Urogynecol J</i> has the highest publication rate and citation frequency, making a significant contribution and demonstrating considerable academic influence in the field. Keyword and cluster analysis reveal that key research areas include validating finite element (FE) models of pelvic floor structures, studying interactions among pelvic support systems, evaluating the impact of vaginal delivery, assessing the effects of various mesh or 3D-printed materials on POP repair, remodeling vaginal connective tissue in POP patients, and biomechanical performance evaluations of pelvic floor tissues. Future research will likely focus on the development of personalized and regenerative treatment strategies. Moreover, advancements in machine learning, various regenerative medicine approaches, and multimodal large-scale FE modeling offer promising insights for development.</p><p><strong>Conclusion: </strong>This study presents a comprehensive analysis of the knowledge system and research directions of the biomechanics of POP, providing valuable guidance for future research endeavors.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1249-1268"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is High-Intensity Interval Training an Option for Post-Kidney Transplant Physical Rehabilitation Programmes? A Scoping Review.","authors":"Viviane Lovatto, Bruna da Silva Sousa, Vera Regina Fernandes da Silva Marães","doi":"10.2147/JMDH.S491605","DOIUrl":"10.2147/JMDH.S491605","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically and broadly review the literature to show the available information on high-intensity interval training for kidney transplant recipients as an adjunct to physical rehabilitation.</p><p><strong>Methods: </strong>A scoping review of high-intensity interval training for post-kidney transplant patients was conducted by searching the PubMed, EMBASE (Elsevier), Scopus (Elsevier), Web of Science, and PEDro databases. Full-text records on the subject were included. Articles not published in English were excluded. The selected articles went through careful production quality analysis using the PEDro scale.</p><p><strong>Results: </strong>The search identified 26 articles, 3 of which met the inclusion criteria. The material demonstrated satisfaction, confidence, improvement in resting heart rate, and absence of adverse effects from high-intensity interval training for kidney transplant recipients.</p><p><strong>Conclusion: </strong>Based on this scoping review, high-intensity interval training for kidney transplant patients may be beneficial for physical and mental aspects and complement physical rehabilitation programmes, but there is a need for more studies with robust samples and long-term follow-up to confirm these benefits.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1231-1239"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Neurodevelopmental Outcomes in Children With Congenital Heart Disease Using Magnetic Resonance Imaging (MRI): Focus on Brain Volume as a Predictor of Neurodevelopmental Abnormalities.","authors":"Ming-Cui Fu, Ye Lin, Feng Yang, Ying Wang, Xu-Ming Mo","doi":"10.2147/JMDH.S508533","DOIUrl":"10.2147/JMDH.S508533","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the neurodevelopmental outcomes in children with congenital heart disease (CHD) using magnetic resonance imaging (MRI), and to assess the role of brain volume metrics as predictors of neurodevelopmental abnormalities.</p><p><strong>Methods: </strong>In this retrospective cohort study, 160 children with CHD treated at Children's Hospital of Nanjing Medical University from January 2020 to December 2023 were analyzed. Patients were classified into normal (DQ ≥ 70, n=106) and abnormal neurodevelopment (DQ < 70, n=54) groups based on Developmental Quotient (DQ) scores. MRI scans were used to measure total brain volume, cortical gray matter, deep gray matter, white matter, and cerebrospinal fluid volumes. Neurodevelopmental assessments focused on adaptive behavior, motor skills, language, and personal-social behavior. ROC analysis was performed to determine the predictive value of brain volume metrics for neurodevelopmental abnormalities.</p><p><strong>Results: </strong>Total brain volume in the normal group (341.82 ± 10.43 mL) was significantly higher than in the abnormal group (323.92 ± 10.24 mL) (P < 0.05). Cortical gray matter volume in the normal group (131.47 ± 4.02 mL) was also significantly greater than in the abnormal group (121.63 ± 6.91 mL) (P < 0.05). No significant differences were observed in white matter, deep gray matter, or cerebrospinal fluid volumes. Children in the abnormal group scored significantly lower in all developmental domains (P < 0.05). ROC analysis showed that total brain volume (AUC = 0.968) and cortical gray matter volume (AUC = 0.936) were strong predictors of neurodevelopmental abnormalities (P < 0.001).</p><p><strong>Conclusion: </strong>Total brain volume and cortical gray matter volume, as measured by MRI, are effective predictors of neurodevelopmental abnormalities in children with CHD and can serve as valuable tools for early neurodevelopmental assessment.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1241-1248"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Needs Assessment for Enhancing Self-Management in People with Lipoedema and the Support Provided by Their Healthcare Professionals.","authors":"Lise Maren Kloosterman, Harriët Jager-Wittenaar, Francine Schneider, Ad Hendrickx, Rienk Dekker, Aldo Scafoglieri","doi":"10.2147/JMDH.S508816","DOIUrl":"10.2147/JMDH.S508816","url":null,"abstract":"<p><strong>Background: </strong>The cause of lipoedema remains unclear, and the condition is currently incurable. Effective self-management is therefore essential for coping with its physical and psychological impacts and the necessary lifestyle adjustments. This study aimed to assess the needs, barriers, and facilitators for enhancing self-management and self-management support from the perspectives of people with lipoedema and the healthcare professionals (HCPs) involved in their care.</p><p><strong>Methods: </strong>The study used a mixed-methods approach, incorporating a narrative review focused on people with chronic conditions and their HCPs, along with focus groups involving people diagnosed with lipoedema and the HCPs involved in their care. The Core Processes of the Intervention Mapping method guided a systematic approach to address the study's objectives. Qualitative data were analyzed using a grounded theory approach.</p><p><strong>Results: </strong>Findings revealed unique self-management barriers for people with lipoedema, including limited awareness and expertise among HCPs, as well as stigmatization from both HCPs and society. Participants identified a need for tailored lifestyle plans, guidance, and support for monitoring progress. Key facilitators included self-management skills, supportive networks, and role models. HCPs noted barriers in communication and collaboration due to a lack of specialized professionals and negative attitudes toward lipoedema. They expressed a need for multidisciplinary/interprofessional teams, accurate diagnosis, patient openness, and reliable information resources. Facilitators included fostering trust, encouraging patient participation, and setting achievable goals.</p><p><strong>Conclusion: </strong>This study underscores the need for tailored self-management interventions for people with lipoedema. The adaptation of existing self-management strategies from other chronic conditions should take into account the specific needs, barriers, and facilitators of people with lipoedema and their HCPs.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1217-1230"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunct Effects of Transcranial Direct Current Stimulation with Mirror Therapy on Motor Control and Muscle Performance in Spastic Quadriplegic Cerebral Palsy Children: A Randomized Clinical Trial.","authors":"Shoaib Waqas, Ashfaq Ahmad, Juliana Barbosa Goulardins, Zainab Hassan, Asif Hanif, Muhammad Tariq","doi":"10.2147/JMDH.S506784","DOIUrl":"10.2147/JMDH.S506784","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) is a birth-related non-progressive neuromotor brain disorder characterized by abnormalities of muscular tonicity, gross and fine motor skills, gait, and posture. It impacts motor control and muscle performance, which are emergent rehabilitation challenges in cerebral palsy children. Mirror therapy (MT) and transcranial direct current stimulation (tDCS) are novel treatment strategies to enhance muscle performance and motor control.</p><p><strong>Methods: </strong>A randomized clinical trial was conducted at Ghurki Hospital Lahore, Pakistan. One hundred and five spastic quadriplegic CP (SQCP) children aged three to seven years were included. Randomization was carried out using Version 1.0 of Randomized Allocation Software. Allocation was done to three groups (35 in each group) with a 1:1:1 ratio with a unique identity number. Group I (tDCS+MT+Routine Physical Therapy (RPT), Group II (MT+RPT), and Group III (tDCS + RPT). Each patient received ten sessions of tDCS and MT, lasting for 15 minutes per side along with 20 minutes of RPT five days a week for ten weeks. Motor control was assessed by the Fugl-Meyer assessment tool, and muscle performance was measured using an isokinetic dynamometer and assessed at baseline, the 2nd, and the 10th week of follow-up and was analyzed using SPSS version 26.</p><p><strong>Results: </strong>The results indicated a significant improvement after 10 weeks in the mean scores of motor control upper extremities, lower extremities, and trunk) with P-values of <0.000, <0.001, and <0.001, respectively. The mean scores of muscle performance (isokinetic strength) for right and left-sided elbow and knee flexors and extensors showed significant changes with P-values of 0.04, 0.01, 0.02, 0.02, 0.03, 0.05, 0.05, and 0.02, respectively. Similarly, muscle performance (isokinetic power) for these muscle groups also demonstrated significant changes, with P-values of 0.04, 0.01, 0.04, 0.02, 0.03, 0.05, 0.05, and 0.02, respectively.</p><p><strong>Conclusion: </strong>tDCS and MT in combination significantly impacted motor control and muscle performance, enhancing elbow and knee musculature strength and power among SQCP patients.</p><p><strong>Trial registration: </strong>IRCT20231227060542N1 on 26-01-2024 https://irct.behdasht.gov.ir/.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1195-1216"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Plan-Do-Check-Action Cycle in Reducing the Incidence of Forearm Hematoma in Patients After Transradial Artery Percutaneous Coronary Interventions.","authors":"Yanqiu Fan, Xiaoyan Zhou","doi":"10.2147/JMDH.S511825","DOIUrl":"10.2147/JMDH.S511825","url":null,"abstract":"<p><strong>Background: </strong>Transradial puncture has the advantages of significantly fewer complications, less patient pain, shorter hospital stays, and reduced hospital costs, but it tends to cause forearm hematoma, so reducing the rate of forearm hematoma is imperative. This study assessed the value of the plan-do-check-act (PDCA) cycle in standardizing nursing management in reduce the incidence of forearm hematoma in patients after transradial artery Percotaneous Coronary Intervention(PCI).</p><p><strong>Methods: </strong>This study was conducted on 260 patients with acute myocardial infarction admitted to our hospital between January 2022 and June 2022 who underwent coronary intervention. The subjects were divided into control-group (n=130) and observation-group (n=130) in accordance with their admission time. The control-group received routine nursing care; and the observation-group, was applied with PDCA nursing management in addition to conventional treatment.</p><p><strong>Results: </strong>The incidence of forearm hematoma in patients after radial artery PCI decreased from 24.62% to 8.46% (P < 0.05).</p><p><strong>Conclusion: </strong>The PDCA cycle management model was effective in reducing the incidence of forearm hematoma without increasing adverse patient outcomes.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1183-1189"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing Factors of Disordered Eating Behavior Among Chinese University Students: The Moderating Role of Physical Activity in the Body Status Chain Mediation Model.","authors":"Cheng Ma, Bo-Ching Chen, Mei-Yen Chen","doi":"10.2147/JMDH.S503106","DOIUrl":"https://doi.org/10.2147/JMDH.S503106","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the impact and mechanism of weight status on the disordered eating behavior of university students, this study conducted a moderated chain mediation model based on the Escape Theory and the Strength Model of Self-Control.</p><p><strong>Methods: </strong>This was a cross-sectional online study conducted at a university in Shanghai. The questionnaire was distributed via communication tools such as WeChat from March 6 to 15, 2022, receiving 2618 valid responses. The moderated chain mediation model was empirically examined with 10,000 Bootstrap samples using AMOS software.</p><p><strong>Results: </strong>(1) Weight status can indirectly predict disordered eating behavior through the mediating effect of body dissatisfaction (β = 0.24, 95% CI: 0.22-0.26, <i>p</i> < 0.001); (2) Body dissatisfaction and negative affect play a chain mediation role in the positive impact of weight status on disordered eating behavior (β = 0.01, 95% CI: 0.01-0.02, <i>p</i> < 0.001); (3) Physical activity moderates the positive impact of negative affect on disordered eating behavior (Diff = -0.11, <i>t</i> = 2.20, <i>p</i> < 0.05) and further plays a moderating role in the chain mediation model (Diff = -0.01, <i>t</i> = 2.30, <i>p</i> < 0.05). Specifically, the higher the level of physical activity among university students, the weaker the impact of negative affect on disordered eating behavior, and the weaker the chain mediation effect; (4) The level of physical activity moderates the relationship between weight status, body dissatisfaction, and disordered eating, suggesting that the higher the level of physical activity, the stronger the mediating role of body dissatisfaction between weight status and abnormal eating (Diff = 0.12, <i>t</i> = 2.74, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>These findings revealed the pathways through which weight status affects the eating behavior of university students and how physical activity might weaken or strengthen this impact. This research supplements prior studies and offers insight into health promotion for university students.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1163-1179"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Online Interactive Platform Services on Oral Health Behaviors in Older Adults with Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial [Response to Letter].","authors":"Qianyu Yin, Zhaowu Chai, Binbin Tao, Ping Liu, Yu Luo, Qinghua Zhao, Bing Yang","doi":"10.2147/JMDH.S523580","DOIUrl":"https://doi.org/10.2147/JMDH.S523580","url":null,"abstract":"","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1193-1194"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric and Bioinformatics Analysis of Renal Impairment in Multiple Myeloma: Trends and Research Hotspots, and Associated Genetic Pathways (2000-2023).","authors":"Huinan Jiang, Xue Bai","doi":"10.2147/JMDH.S501551","DOIUrl":"https://doi.org/10.2147/JMDH.S501551","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to perform a bibliometric visual analysis and bioinformatics analysis to explore the research hotspots and trends of renal impairment in multiple myeloma, including the associated genes and signal pathways over the past two decades.</p><p><strong>Methods: </strong>The Web of Science Core Collection database was utilized as the data source to retrieve literature on renal impairment in multiple myeloma from 2000 to 2023. The selected literature was analyzed using bibliometric and bioinformatics software, including Bibliometrix, VOSviewer 1.6.16, Citespace 5.7R5 and Cytoscape 3.7.1 software.</p><p><strong>Results: </strong>This study encompassed 2152 articles that were published from 2000 to 2023, demonstrating an overall upward trend in annual publications and citations. Among the set of 27 core journals examined, the \"CUREUS JOURNAL OF MEDICAL SCIENCE\" exhibited the highest frequency of publications, while \"BLOOD\" emerged as the most frequently cited source. The global research on renal impairment in multiple myeloma research included contributions from 84 countries/regions, with the United States leading in terms of publication output and Mayo Clinic playing a central role in fostering inter-agency collaboration. Keywords such as \"daratumumab\", \"carfilzomib\", \"diagnostic criteria\" and \"kidney biopsy\" included recent research hotspots. We hypothesized that the TP53, AKT1, MYC, and CTNNB1 genes were involved in epithelial cell proliferation and the positive regulation of the MAPK cascade through signaling receptor activator activity, receptor-ligand interactions, and cytokine receptor binding. Simultaneously, they were implicated in renal impairment in multiple myeloma via the PI3K/Akt and MAPK signaling pathways.</p><p><strong>Conclusion: </strong>This research employed bibliometric visual analysis and bioinformatics analysis to identify the current focus and future directions of studying renal impairment in multiple myeloma, as well as to explore the associated genes and signaling pathways. The management of renal impairment in patients with multiple myeloma has a significant impact on medical costs. Clinical physicians need to consider how to allocate medical resources reasonably, ensure that patients can receive necessary diagnosis and treatment, and explore cost-effective treatment options. The management of these patients requires interdisciplinary medical services, which should integrate basic and clinical research, especially the development of new treatment plans, to improve patients' quality of life and guide future treatment choices.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1147-1162"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}