Journal of Multidisciplinary Healthcare最新文献

{"title":"Research Advance of Causal Inference in Clinical Medicine: A Bibliometrics Analysis via Citespace.","authors":"Guoqiang Qin, Jianxiang Wei, Yuehong Sun, Wenwen Du","doi":"10.2147/JMDH.S516826","DOIUrl":"https://doi.org/10.2147/JMDH.S516826","url":null,"abstract":"<p><strong>Objective: </strong>Causal inference in clinical medicine provides scientific evidence for precision medicine and individualized treatment by revealing the true associations between interventions and health outcomes. This study aims to conduct a comprehensive bibliometric analysis to identify current research trends, primary themes, and future directions for the application of causal inference in clinical medicine.</p><p><strong>Methods: </strong>We conducted a literature search in the Web of Science database using causal inference and medical terminology as subject keywords, covering the period from January 1986 to December 2024. After screening, we obtained 4,316 documents for analysis. Utilizing CiteSpace to generate network diagrams, we analyzed data related to the number of publications, citation analysis, collaboration relationships, keyword co-occurrence, and highlighted terms to illustrate the knowledge map and collaboration network in this field.</p><p><strong>Results: </strong>Publications on medical causal inference shows a fluctuating growth trend over time. The United States was the top contributors to this field. Harvard University is the leading research institution. George David Smith is the most prolific author, Robbins JM is the most cited scholar. The major research hotspots concentrated in fields such as epidemiology, coronary heart disease and health. Notably, marginal structural models, counterfactual forecasting, and Mendelian randomization have consistently been key methodologies in research. The burstness of keywords reveals that big data, DNA methylation, and robust estimation are emerging research directions.</p><p><strong>Conclusion: </strong>In clinical research, counterfactual forecasting provides prospective guidance for optimizing clinical strategies; Mendelian randomization helps uncover potential therapeutic targets; and marginal structural models enhance the accuracy of causal effect estimation in clinical studies. The future integration of various data sources to improve causal inference methods is anticipated to enhance the sensitivity and specificity of trials, ultimately elucidating the complex mechanisms of diseases and drug effects. The literature retrieve strategy and the metrics of the tools adopted may have a certain impact on the results of this study.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2603-2627"},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THRIVE Prevent Postoperative Hypoxemia in Elderly Patients Undergoing Laparoscopic Surgery in PACU: A Randomized Controlled Clinical Trial.","authors":"Xingxing Chen, Kang Gu, Yunqing Yang, Bingbing Zhou, Yunchang Mo, Yingying Tu","doi":"10.2147/JMDH.S520952","DOIUrl":"https://doi.org/10.2147/JMDH.S520952","url":null,"abstract":"<p><strong>Background: </strong>Postoperative hypoxemia frequently occurs in elderly individuals undergoing laparoscopic procedures, often leading to severe consequences and prolonged stays in the post-anesthesia care unit (PACU). Conventional oxygen therapy methods are not entirely effective in preventing hypoxemia. Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) delivers high-flow oxygen at rates up to 60 L/min, potentially enhancing respiratory function and tolerance to hypoxia.</p><p><strong>Objective: </strong>To assess the effectiveness, safety, and patient tolerance of THRIVE in the early prevention of postoperative hypoxemia in elderly patients following laparoscopic surgery with general anesthesia.</p><p><strong>Methods: </strong>This prospective, multicenter, randomized controlled trial enrolled 200 elderly patients undergoing laparoscopic surgery who were safely extubated after general anesthesia. Participants were randomly allocated to receive either conventional nasal cannula oxygen therapy or THRIVE. Between January 2023 and December 2023, cases were recruited from three participating centers. The main outcome measured was the occurrence of hypoxemia in the PACU. Secondary outcomes encompassed lung ultrasound scores after oxygen therapy, frequency of jaw lifting, reintubation rate, adverse events, and subjective patient comfort.</p><p><strong>Results: </strong>The incidence of hypoxemia was significantly lower in the THRIVE group compared to the standard oxygen therapy group (0% vs 29.2%; χ² = 35.245; <i>P</i> < 0.001). The need for jaw lifting was also significantly reduced in the THRIVE group (5.1% vs 29.2%; <i>P</i> = 0.019). Moreover, patients receiving THRIVE demonstrated better lung aeration, as indicated by improved lung ultrasound scores (<i>z</i> = 3.016; <i>P</i> = 0.003), and reported significantly higher comfort levels in the PACU (<i>z</i> = 3.141; <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>THRIVE is an effective strategy for reducing postoperative hypoxemia in elderly individuals undergoing laparoscopic procedures with general anesthesia. It facilitates pulmonary function recovery, enhances patient comfort, and may serve as a valuable intervention in the PACU setting.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2651-2660"},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Trends in the Mental Health Status of Healthcare Workers at COVID-19 Wards Three Years After the COVID-19 Pandemic Outbreak in Saudi Arabia.","authors":"Sami Hamoud Alharbi, Alia Mohammed Almoajel, Shabana Tharkar, Abdullah Hamoud Alharbi, Khalid Almutairi, Hanan Abdullah Alzaidi, Basmah Faisal Kattan","doi":"10.2147/JMDH.S509252","DOIUrl":"https://doi.org/10.2147/JMDH.S509252","url":null,"abstract":"<p><strong>Background: </strong>The current study aimed to investigate the severity of anxiety and depression symptoms among the healthcare workers of COVID-19 wards three years after the pandemic outbreak in Saudi Arabia.</p><p><strong>Methods: </strong>An online cross-sectional survey was conducted during the fourth quarter of 2022 and early 2023 at the COVID-19 wards of public primary healthcare hospitals of the AlQassim region of Saudi Arabia. The sample included 323 healthcare workers including physicians, nurses, laboratory, and imaging personnel. The Generalized Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9) questionnaires were used to collect data using the self-administered approach. The degree of severity of anxiety and depressive symptoms were the main outcome variables. Descriptive and inferential statistics were derived using Statistical Package for Social Science (SPSS) software version 28.0.</p><p><strong>Results: </strong>Three years following the outbreak of the pandemic, a transition toward a high prevalence of mild symptoms of anxiety and depression was noted. The present study reported 85.1%, 8.4%, and 6.5% mild, moderate, or moderately severe depression and 90.7%, 6.8%, and 2.5% anxiety, respectively. Depression was more common in men (t=3.009; p=0.003). Phlebotomists, x-ray and imaging personnel, and paramedics showed a strong association with symptoms of depression (t=8.36; p< 0.001) and anxiety (t= 10.325; p<0.001). Sleep deprivation, fatigue, loss of interest, and changes in eating behavior were depressive symptoms with a high degree of severity. Anxiety symptoms that showed a high degree of severity were having trouble relaxing and getting annoyed quickly. An overall depressive and anxiety score of 16.5 and 12.8 was obtained.</p><p><strong>Conclusion: </strong>The long-term impact of the pandemic on healthcare workers in COVID-19 wards includes the persistence of depression and anxiety symptoms. These findings highlight the need for implementing mental health wellness programs and coping strategies that reduce work stress and improve the quality of life.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2581-2590"},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Status of Patients with Thyroid Nodules: A Cross-Sectional Study.","authors":"Peng Wang, Jing Yan, Honghai He, Ying Che","doi":"10.2147/JMDH.S513795","DOIUrl":"https://doi.org/10.2147/JMDH.S513795","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the mental health status of patients with high-risk and low-risk thyroid nodules (TNs), and the potential psychological risk factors that may exist in patients with high-risk nodules.</p><p><strong>Patients and methods: </strong>In this cross-sectional study, a total of 7645 adults who participated in physical examinations from January 2021 to December 2023 were included. During the physical examination, they all completed thyroid ultrasound examinations and laboratory tests, and filled out self-administered questionnaires, as well as the Symptom Checklist-90 (SCL-90) and the Stress Self-Assessment Questionnaire-53 (SSQ-53). These were used to collect general information, mental health status, and stress levels of the subjects. According to the degree of malignant risk, TNs were categorized into high-risk groups (HRG) and low-risk groups (LRG). Differences between the two groups were compared in terms of general information, mental health status scores, and laboratory indicators.</p><p><strong>Results: </strong>The overall detection rate of TNs was 34.5%, with a significantly higher rate in women. There were significant differences in age and gender between HRG and LRG; The total score of SCL-90 in the HRG was significantly higher than that in LRG (128.78±45.65 vs 120.59±31.68, p=0.044); HRG exhibited a higher proportion of positive rates in the somatization (P=0.033) and anxiety (P=0.048) factors of the SCL-90. Among the 10 factors of SCL-90, the scores of somatization (P=0.011), obsessive-compulsive (P=0.010), interpersonal sensitivity (P=0.032), depression (P=0.036) and additional factors (diet and sleep) (P=0.008) in HRG were significantly higher. The results of SSQ-53 suggest that the overall stress level in HRG is higher, and the cognitive stress is significantly higher than that in LRG (P=0.003). Multivariate logistic regression analysis showed that age, gender, and SCL-90 total score were risk factors for high-risk TNs.</p><p><strong>Conclusion: </strong>High-risk TNs are more common in females and older adults. The existence of high-risk TNs is related to poor mental health status.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2641-2650"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Pain Empathy Among Doctors, Nurses and Patients: A Scoping Review.","authors":"Wan-Qiong Zhou, Yi-Tian Gao, Cheng-Rui Zhang, Ying Xing, Lan-Shu Zhou, Wei Luan","doi":"10.2147/JMDH.S519647","DOIUrl":"https://doi.org/10.2147/JMDH.S519647","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to systematically assess the existing body of research on pain empathy among healthcare workers and patients, with the goal of enhancing both understanding and clinical application.</p><p><strong>Methods: </strong>Studies were retrieved from seven databases: PubMed, EBSCO, The Cochrane Library, Embase, CBM, CNKI, and Wanfang, with a search date limit from database inception to September 13, 2024. Inclusion and exclusion criteria were established based on the PCCs (Population, Concept, Context, Study design) principle. The research was independently screened and summarized by two researchers. A pre-designed data extraction form was used for information extraction from the included studies.</p><p><strong>Results: </strong>A total of 4729 studies were initially identified, with 50 studies included after screening. The participants were categorized into six groups: pain patients, nurses, patients with neurological diseases, cancer patients, patients with psychiatric disorders, doctors, and medical students. The studies employed 75 distinct research tools, including the Empathy for Pain Scale (EPS), the Interpersonal Reactivity Index (IRI), pain empathy paradigms, and the Visual Analogue Scale (VAS), along with various detection technologies, such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Factors influencing pain empathy included psychological factors, individual traits, and social influences. Mechanistic studies explored the neural substrates of emotional empathy (anterior insula, anterior cingulate cortex, amygdala), cognitive empathy (precuneus and parietal-occipital junction), the relationship between emotional regulation and cognitive processing, and the synergistic interactions of multiple brain regions.</p><p><strong>Conclusion: </strong>This review offers a comprehensive overview of research on pain empathy among healthcare workers and patients, emphasizing its multidisciplinary nature and complexity. It provides theoretical foundations and outlines potential directions for future research, which may include the adoption of unified research standards, interdisciplinary collaboration, the application of advanced technologies, and cross-cultural studies to further advance the field of pain empathy.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2565-2580"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Clinical Analysis of Rilonacept in the Treatment of Cryopyrin-Associated Periodic Syndromes: A Systematic Review.","authors":"Tian Zhang, Yue Yu, Jiajing Chen, Zhao Zhao, Moting Qian, Yufei Zhang, Chunlai Ma, Feng Chang","doi":"10.2147/JMDH.S500838","DOIUrl":"https://doi.org/10.2147/JMDH.S500838","url":null,"abstract":"<p><strong>Objective: </strong>Cryopyrin-associated periodic syndromes (CAPS), a group of interleukin-1 (IL-1) mediated autoinflammatory disorders, were incorporated into China's \"Second List of Rare Diseases\" in 2023. Notably, rilonacept, an IL-1 inhibitor approved in the United States since 2008, has been a key treatment for CAPS. However, comprehensive analysis of its efficacy and safety are limited. This systematic review aims to assess rilonacept for CAPS treatment and provide evidence-based therapeutic recommendations.</p><p><strong>Methods: </strong>We used medical subject headings terms and free-text keywords related to rilonacept and CAPS to perform a systematic literature search. This search covered databases including PubMed, Ovid/Embase, The Cochrane Library, and Chinese databases (CNKI, Wanfang, and VIP) from their inception to September 30, 2024. A multidimensional systematic review was then conducted, collating the efficacy, safety, cost-effectiveness, innovativeness, suitability, and accessibility of rilonacept in treating CAPS.</p><p><strong>Results: </strong>Out of 1223 screened publications, three clinical studies including two sequential randomized controlled trials were selected based on the established criteria. Notably, no economic evaluations were identified. Treatment with rilonacept resulted in a reduction of approximately two points in key symptom scores for patients, with significant improvements in all outcome measures such as the number of flare days and high-sensitivity C-reactive protein levels. Adverse reactions were mostly mild to moderate, and with favorable long-term tolerability. Rilonacept meets current clinical needs due to its ease of use, demonstrating strong innovativeness and suitability. Its cost-effectiveness and accessibility warrant further examination post-market entry, yet it exhibits considerable potential for widespread use.</p><p><strong>Conclusion: </strong>Rilonacept demonstrates significant effectiveness in treating CAPS with a favorable overall safety profile. It shows high innovativeness and acceptable suitability, with the potential for improved cost-effectiveness and accessibility. We anticipate that the effective treatment of CAPS with rilonacept will encourage further clinical and fundamental research, offering valuable insights for the treatment of other autoinflammatory diseases.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2591-2602"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Cooling Blankets for Early Temperature Management in Heat Stroke Patients: A Multicenter Retrospective Cohort Study.","authors":"Lan Chen, Dingping Jin, Zhumei Gong, Liyun Lu, Junlu Zhao, Shuying Xu, Xiaoling Yang, Yuping Zhang, Xiuqin Feng","doi":"10.2147/JMDH.S522541","DOIUrl":"10.2147/JMDH.S522541","url":null,"abstract":"<p><strong>Objective: </strong>Water circulation cooling blankets are commonly used in heat stroke management, but their efficacy and safety remain insufficiently studied. This study aimed to assess the cooling effect of the cooling blanket within the first 24 hours after emergency department admission in patients with heat stroke.</p><p><strong>Methods: </strong>Retrospective data were collected from six hospitals. The primary outcomes included body temperature at 0.5 and 2 hours post-treatment and changes in temperature during these intervals. The cooling effect was assessed using logistic regression, generalized additive mixed models, and genetic and propensity score matching. Test effectiveness was evaluated based on the non-inferiority test formula.</p><p><strong>Results: </strong>A total of 191 patients were included, with 84 (44.0%) receiving cooling with the blanket. The mean cooling duration was 2 hours. Body temperatures at 0.5 hours were 39.80 ± 0.96 °C in the cooling blanket group versus 39.26 ± 0.94 °C in the non-cooling blanket group. At 2 hours, temperatures were 38.08 ± 1.00 °C and 37.84 ± 0.96 °C, respectively. No significant differences were found in body temperature at 0.5 hours (β, -0.19 [95% CI, -0.50, 0.12]; P = 0.242) or 2 hours (β, -0.24 [95% CI, -0.57, 0.09]; P = 0.161) between the cooling blanket and non-cooling blanket groups. Similarly, no significant differences in temperature changes at 0.5 or 2 hours were observed. After adjusting for propensity scores, no differences in temperature were found in the matching cohort. The non-inferiority criterion was met, with effectiveness scores of 1.000 at 0.5 hours and 0.998 at 2 hours.</p><p><strong>Conclusion: </strong>The cooling blanket demonstrated no significant temperature reduction advantage compared to the non-cooling blanket group. High-quality randomized controlled trials remain necessary to further evaluate its therapeutic role in heat stroke management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2629-2639"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Discharge Education: Evidence for Enhancing Family Preparedness for Premature Infants.","authors":"Lingping Zhang, Junjie He, Yue Zhou, Xiaomei Li","doi":"10.2147/JMDH.S515110","DOIUrl":"https://doi.org/10.2147/JMDH.S515110","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to systematically search, screen, evaluate, and synthesize evidence regarding the effectiveness of discharge education in enhancing family preparedness for premature infants. The ultimate goal was to provide evidence-based references for implementing discharge education for family caregivers, thereby improving families' discharge readiness and enhancing home care and infant health.</p><p><strong>Methods: </strong>Systematic searches were conducted across BMJ Best Practice, UpToDate, the Cochrane Library, and other relevant databases from October 2014 to October 2024. The collected literature comprised clinical decisions, guidelines, expert consensuses, systematic reviews, meta-analyses, best practices, and randomized controlled trials related to discharge education for enhancing family preparedness for premature infants. Relevant evaluation tools were selected based on the type of literature to assess methodological quality, and the evidence was extracted, summarized, and organized.</p><p><strong>Results: </strong>A total of 1724 documents were searched. Ultimately, ten pieces of literature were selected based on the inclusion and exclusion criteria, comprising one clinical decision, one guideline, one expert consensus, two systematic reviews, one meta-analysis, one best practice, and three randomized controlled trials. From these literature, a total of thirty-three pieces of evidence were extracted and synthesized across five domains: assessment, planning, implementation, evaluation, and support.</p><p><strong>Conclusion: </strong>This study synthesized evidence on discharge education for premature infant' families, revealing key insights for clinical practice. It emphasized tailored education plans, early family involvement, multidisciplinary collaboration, and diverse teaching methods. Implementing these practices is expected to improve families' discharge readiness, thereby promoting better infant health.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2551-2563"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening.","authors":"Min Huang, Yunlong Jing, Xiangyue Peng, Jiang Xie, Qin Zhao, Jiang-Long Yin, Wen-Du Xiao, Si-Jun Zhao, Hong-Ju Tian","doi":"10.2147/JMDH.S506757","DOIUrl":"https://doi.org/10.2147/JMDH.S506757","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of hearing impairment in neonates and identify associated risk factors through auditory brainstem response (ABR) screening.</p><p><strong>Study design: </strong>A prospective observational longitudinal study was conducted involving 158 infants, with Automated Auditory Brainstem Response (AABR) evaluations performed by 6 months of age.</p><p><strong>Setting: </strong>The study was undertaken in a hospital-based neonatal care unit.</p><p><strong>Methods: </strong>Infants with significant hearing loss in one or both ears were referred for further assessment and rehabilitation. The relationship between microRNAs (MiRNAs) and congenital hearing loss was confirmed through differential expression levels in newborns.</p><p><strong>Results: </strong>Of the 158 infants, 8 showed abnormal AABR results. Univariable analysis identified 5 potential risk factors associated with hearing deterioration, with multivariable analysis pinpointing the number of maternal embryos, cytomegalovirus, and miR-431 as independently associated with hearing loss at 6 months (<i>P</i> = 0.004).</p><p><strong>Conclusion: </strong>Early detection of hearing loss is vital for child development. Given the high incidence of hearing impairment in the study population, universal newborn hearing screening is essential. Assessment of miRNAs expression levels, maternal embryo count, and prenatal infections should be integrated into screening protocols for infants admitted for over 24 hours to prevent oversight of neural hearing loss cases.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2541-2550"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous EEG-fMRI Study.","authors":"Ya-Qin Li, Zi-Wen Chen, Hui He, Yi-Wei Liu, Fang Ye, Zuo-Qin Yang, De-Hua Li, Qiong-Nan Bao, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Ping Xu, Shi-Qi Yang, Zi-Wen Wang, Zi-Han Yin, Fan-Rong Liang","doi":"10.2147/JMDH.S516654","DOIUrl":"https://doi.org/10.2147/JMDH.S516654","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) is characterized by abnormal changes in spatiotemporal neuronal specificity responses. Simultaneous electroencephalogram (EEG)-functional magnetic resonance imaging (fMRI) offers a novel approach to measure these changes. Emerging evidence suggests that acupuncture may enhance cognitive function by modulating spatial or temporal central activity in individuals with MCI. However, no studies have investigated the detailed mechanisms underlying this effect.</p><p><strong>Methods: </strong>This randomized controlled neuroimaging trial will enroll 60 patients with MCI, who will be randomly assigned to one of two groups: a real acupuncture (RA) group or a sham acupuncture (SA) group. The trial period will last 12 weeks, during which participants will receive 24 sessions of acupuncture twice weekly. The primary outcome measure will be the improvement in the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) score from baseline to post-treatment. Secondary outcomes will include improvements in specific cognitive domains such as memory, executive function, language, and attention. Simultaneous EEG-fMRI combined with correlation analysis, regression analysis, and joint independent component analysis (jICA) will elucidate the spatiotemporal central modulatory mechanisms of acupuncture in MCI patients.</p><p><strong>Discussion: </strong>This study may reveal that real acupuncture can treat cognitive impairment by modulating the brain's spatiotemporal neuronal specificity activity. Our findings will provide scientific evidence for the efficacy of acupuncture in the treatment of MCI and further add to the understanding of the neural mechanisms.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, identifier [ChiCTR2400084666].</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2523-2539"},"PeriodicalIF":2.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}