Journal of Multidisciplinary Healthcare最新文献

{"title":"Impact of Medications for Stable Angina Pectoris on Osteoporosis: A Review of Current Evidence.","authors":"Rui-Ang Wang, Chen-Xi Xu","doi":"10.2147/JMDH.S526091","DOIUrl":"https://doi.org/10.2147/JMDH.S526091","url":null,"abstract":"<p><p>Stable angina pectoris (SAP) and osteoporosis (OP) are both prevalent conditions among the elderly population. Compared to SAP, the prevention and management of OP are often neglected. Furthermore, certain medications used long-term for SAP may exert significant effects on bone metabolism. This review summarizes the impact of commonly prescribed SAP medications on OP. Extensive research indicates that nitrates not only promote vascular and osteogenic coupling via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway, enhancing the osteogenic effects of estrogen and mechanical stimulation, but also regulate bone immunity through receptor-interacting protein kinase 3 (RIPK3), promoting bone remodeling. β-Blockers promote osteoblast proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via the cAMP/PKA signaling pathway, stimulating bone formation, while concurrently inhibiting osteoclasts and reducing bone resorption. Statins, which inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase to regulate lipid metabolism, also upregulate bone morphogenetic protein 2 (BMP-2) expression, inducing osteogenic differentiation of BMSCs, and inhibit osteoclast differentiation and activity, thereby promoting bone formation and suppressing bone resorption. Aspirin (AS) activates osteoblasts and their precursor cells, stimulates angiogenesis, mitigates inflammatory responses, promotes bone regeneration, and accelerates bone repair. However, clopidogrel reduces osteoblast numbers via P2 receptor-mediated extracellular nucleotide signaling and promotes adipogenic differentiation of BMSCs; furthermore, its metabolism can decrease serum 25-hydroxyvitamin D levels, adversely affecting skeletal health. Calcium channel blockers (CCBs) exhibit a largely neutral effect on bone health in clinical evidence, although basic research suggests potential benefits. The heterogeneity in research findings profoundly reflects the complexity of bone metabolism and the limitations of current studies. Synthesizing the evidence, preferential consideration may be given to nitrates, β-blockers, statins, and aspirin for SAP patients with coexisting OP or at significant risk; when clopidogrel is used, enhanced monitoring of bone parameters and intensified prevention and treatment of OP are recommended.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4121-4131"},"PeriodicalIF":2.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Auditory Mismatch Negativity in Patients with Chronic Disorders of Consciousness Following Intracerebral Haemorrhage: A Prognostic Prediction Study.","authors":"Xuehai Lv, Nuan Yang, Jingwei Lv, Linxi Li, Yuemin Gao, Zhengmao Xiang, Zhengfan Li, Xiaoguang Lang, Dan Tao, Yuqin Zhao, Haili Duan, Hongling Li","doi":"10.2147/JMDH.S519306","DOIUrl":"https://doi.org/10.2147/JMDH.S519306","url":null,"abstract":"<p><strong>Objective: </strong>To examine the clinical features of auditory mismatch negativity (MMN) and its potential utility in prognostic prediction in patients with chronic disorders of consciousness (DOC) following intracerebral haemorrhage (ICH).</p><p><strong>Methods: </strong>Between September 2023 and July 2024, 24 patients with chronic DOC following ICH were recruited. The Coma Recovery Scale-Revised (CRS-R) was used to assess the patients' level of consciousness, dividing them into vegetative state, minimally conscious state and escaped minimally conscious state groups. Auditory MMN data were collected from each group using an oddball paradigm, and differences in MMN amplitude and latency were compared. Follow-up was conducted 3 months later. Patients were categorised into favourable and unfavourable outcome groups based on the Glasgow Outcome Scale scores. The receiver operating characteristic curve method was utilised to evaluate the prognostic predictive power of significant indicators, establishing cut-off values.</p><p><strong>Results: </strong>The amplitude of auditory MMN was different in patients with varying levels of consciousness. The MMN amplitude at electrode Cz was associated with prognosis (P < 0.05), and the area under the curve was 0.850 (95% CI: 0.79-0.91). Moreover, MMN amplitudes at Cz were dichotomised at a value of 1.19 μV, with a sensitivity and specificity of 87.5% and 80.0%, respectively, for the prognosis prediction. The prediction value improved when combined with the CRS-R and the Glasgow Coma Scale.</p><p><strong>Conclusion: </strong>Auditory MMN amplitude, particularly at electrode Cz, serves as a reliable prognostic indicator for patients with chronic DOC following ICH. Its integration with clinical scales enhances predictive accuracy, offering valuable insights for clinical decision-making and patient management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4133-4143"},"PeriodicalIF":2.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Applications and Potential Mechanism of Cold Acclimation Therapy.","authors":"Yongxing Wang, Yajun Wang, Dezhi Han, Weijing Sun, Yaqun Qiao, Conghui Wang, Xu Zhang, Jinlong Xu","doi":"10.2147/JMDH.S525146","DOIUrl":"https://doi.org/10.2147/JMDH.S525146","url":null,"abstract":"<p><p>Cold acclimation therapy has emerged as a notable therapeutic approach with physical therapy and clinical medicine. Driven by the rising demand for effective pain management, sports recovery, and inflammation control, several studies have examined the physiological mechanisms and diverse applications of cold acclimation therapy. Current research shows that cold acclimation therapy can effectively alleviate both acute and chronic pain, promote post-exercise recovery, and mitigate inflammatory responses. Despite its potential, challenges persist in its clinical application, including the determination of precise clinical indications, optimal timing of intervention, and potential adverse effects. This review summarizes the fundamental principles, clinical applications, current research progress, and future potential of cold acclimation therapy, aiming to provide a reference for clinical practice. Furthermore, the future applications of cold acclimation therapy in medical practice is discussed, emphasizing its importance and development prospects in modern healthcare.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4113-4120"},"PeriodicalIF":2.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trends and Hotspots of Acupuncture Therapy on Allergic Diseases From 2004 to 2024: A Bibliometric Analysis.","authors":"Yanrong Lv, Ziyi Jiang, Jingwen Zhang, Xiaoyan Zheng, Xiaoping Tian, Jia Liu, Jie Yang","doi":"10.2147/JMDH.S528646","DOIUrl":"https://doi.org/10.2147/JMDH.S528646","url":null,"abstract":"<p><strong>Background: </strong>Over the past two decades, acupuncture has increasingly been applied in the treatment of allergic diseases, with a corresponding increase in the number of published articles.</p><p><strong>Objective: </strong>To investigate the hotspots and frontiers of global scientific output in acupuncture research for allergic diseases over the past two decades.</p><p><strong>Methods: </strong>The Web of Science Core Collection was used to collect literature on acupuncture therapy for allergic diseases, which spanned from 2004 to 2024. We used CiteSpace 6.3.1 and VOSviewer to conduct visual analysis of the relevant contents of the literature, and constructed a network graph in the software by using information such as the publication date of the article, country, institution, author, and journal.</p><p><strong>Results: </strong>A total of 423 documents were retrieved. The results indicate that the annual publication volume on acupuncture treatment for allergic diseases has shown a fluctuating upward trend. China is the leading country in terms of publications. KyungHee University emerges as the most productive institution. Brinkhaus, B. is the most prolific author. <i>Medicine</i> is the most popular journal. <i>Annals of Internal Medicine</i> has the highest impact factor. Allergic rhinitis, the efficacy and safety of acupuncture as an alternative therapy for allergic diseases, and the mechanisms underlying acupuncture treatment are at the forefront of research in this field.</p><p><strong>Conclusion: </strong>This study provides a comprehensive summary of the research hotspots and trends in the field of acupuncture treatment for allergic diseases over the past two decades, which can assist researchers in better understanding the development of this field and offer directions for future research.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4071-4087"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Evaluation of an AI-Based Pneumothorax Detection Model: Clinical Comparison with Physicians in Edge and Cloud Environments.","authors":"Ismail Dal, Hasan Burak Kaya","doi":"10.2147/JMDH.S535405","DOIUrl":"10.2147/JMDH.S535405","url":null,"abstract":"<p><strong>Background: </strong>Accurate and timely detection of pneumothorax on chest radiographs is critical in emergency and critical care settings. While subtle cases remain challenging for clinicians, artificial intelligence (AI) offers promise as a diagnostic aid. This retrospective diagnostic accuracy study evaluates a deep learning model developed using Google Cloud Vertex AI for pneumothorax detection on chest X-rays.</p><p><strong>Methods: </strong>A total of 152 anonymized frontal chest radiographs (76 pneumothorax, 76 normal), confirmed by computed tomography (CT), were collected from a single center between 2023 and 2024. The median patient age was 50 years (range: 18-95), with 67.1% male. The AI model was trained using AutoML Vision and evaluated in both cloud and edge deployment environments. Diagnostic accuracy metrics-including sensitivity, specificity, and F1 score-were compared with those of 15 physicians from four specialties (general practice, emergency medicine, thoracic surgery, radiology), stratified by experience level. Subgroup analysis focused on minimal pneumothorax cases. Confidence intervals were calculated using the Wilson method.</p><p><strong>Results: </strong>In cloud deployment, the AI model achieved an overall diagnostic accuracy of 0.95 (95% CI: 0.83, 0.99), sensitivity of 1.00 (95% CI: 0.83, 1.00), specificity of 0.89 (95% CI: 0.69, 0.97), and F1 score of 0.95 (95% CI: 0.86, 1.00). Comparable performance was observed in edge mode. The model outperformed junior clinicians and matched or exceeded senior physicians, particularly in detecting minimal pneumothoraces, where AI sensitivity reached 0.93 (95% CI: 0.79, 0.97) compared to 0.55 (95% CI: 0.38, 0.69) - 0.84 (95% CI: 0.69, 0.92) among human readers.</p><p><strong>Conclusion: </strong>The Google Cloud Vertex AI model demonstrates high diagnostic performance for pneumothorax detection, including subtle cases. Its consistent accuracy across edge and cloud settings supports its integration as a second reader or triage tool in diverse clinical workflows, especially in acute care or resource-limited environments.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4099-4111"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of an Agricultural Safety and Health Literacy Tool.","authors":"Gyeong-Ye Lee, Ki-Soo Park","doi":"10.2147/JMDH.S528979","DOIUrl":"10.2147/JMDH.S528979","url":null,"abstract":"<p><strong>Background: </strong>Health literacy in the workplace plays a crucial role in preventing work-related diseases and injuries. This study aims to develop and validate an instrument to measure Agricultural Safety and Health Literacy (ASHL) based on existing occupational health literacy tools.</p><p><strong>Methods: </strong>The development of the instrument involved preliminary item development, expert evaluation, and preliminary testing. Cronbach's α, a coefficient that measures the internal consistency of each item, was measured for reliability. Exploratory factor analysis and confirmatory factor analysis were performed to examine the construct validity, and predictive validity was evaluated using paired <i>t</i>-tests for changes in health literacy before and after education.</p><p><strong>Results: </strong>The overall Cronbach's α for the instrument was 0.92, indicating high reliability. In the exploratory factor analysis, five factors were extracted explaining 64.4% of the total variance. As a result of confirmatory factor analysis, the goodness-of-fit index (GFI) was shown as GFI=0.851, adjusted GFI=0.816, comparative fit index=0.901, normed fit index=0.835, root mean square error of approximation=0.071, and χ²/df=2.2. These results indicated acceptable model fit. The change in score from before to after the educational intervention was confirmed to have predictive validity with a significant increase in all areas (p<0.005).</p><p><strong>Conclusion: </strong>This study describes the development of an instrument for understanding ASHL for use in evaluating the health and safety of farmers. The developed instrument will be used in Korea to improve the health behavior of farmers and to prevent and manage various health problems that may occur in the agricultural working environment.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4059-4070"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Stoma Care: Enhancing Knowledge, Confidence, and Support Through Collaborative Approaches Between Doctors and Parental Communities for Children with Stomas.","authors":"Leecarlo Millano Lumban Gaol, Lavenia Quinta Saraswati, Grace Shintauli Gultom, Melian Anita, Yohanes Firmansyah, Fiona Valencia Setiawan, Bryan Anna Wijaya","doi":"10.2147/JMDH.S517481","DOIUrl":"10.2147/JMDH.S517481","url":null,"abstract":"<p><strong>Introduction: </strong>Effective postoperative care is pivotal, and parents play a vital role in managing complications and outcomes. Despite their importance, parents often struggle with the complexities of stoma care. Managing pediatric stomas necessitates a collaborative effort between healthcare professionals and community support, forming a multidisciplinary team that empowers parents with the knowledge and confidence required for effective stoma management.</p><p><strong>Purpose and objectives: </strong>This study assesses the impact of collaborative efforts between doctors and community support systems on children's quality of stoma care.</p><p><strong>Methods: </strong>A cross-sectional study involving 224 participants evaluated the influence of stoma support communities in Jakarta. The study used a validated 11-question questionnaire to measure community impact and stoma care knowledge.</p><p><strong>Results: </strong>Spearman Correlation analysis indicated significant relationships between doctor-patient communication and factors such as the stoma's condition (r:0.285, p<0.001), knowledge (r:0.417, p<0.001), support in stoma care (r:0.458, p<0.001), self-confidence (r:0.440, p<0.001), support systems (r:0.407, p<0.001), and ease of access to care (r:0.357, p<0.001). Multivariate analysis highlighted that the quality of doctor-patient communication significantly affects stoma condition, support systems, self-confidence, and access to care (p<0.025). ROC prediction analysis showed that effective doctor-patient communication through Komunitas Stoma Pada Anak Jakarta (KOSPAJA) significantly enhances support and self-confidence in stoma care (A>0.70).</p><p><strong>Conclusion: </strong>The collaboration between doctors and community support significantly enhances parents' knowledge, confidence, and support in managing their child's stoma, leading to improved care quality and reduced complication rates.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4089-4098"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Based Strategies for Preventing Falls in Community-Dwelling Older Adults.","authors":"Xiang An, YuanXin Pan, ChenHong He, Yi Liang","doi":"10.2147/JMDH.S535977","DOIUrl":"10.2147/JMDH.S535977","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and summarize the best evidence for fall prevention measures in community-dwelling elderly individuals.</p><p><strong>Methods: </strong>A systematic search was conducted in databases including UpToDate, BMJ Best Practice, the Joanna Briggs Institute (JBI) Evidence-Based Healthcare Center, National Guidelines Clearinghouse, China Medical Guidelines Network, NICE, Scottish Intercollegiate Guidelines Network, and the Ontario Nurses' Association website. Additional searches were performed in the Cochrane Library, CINAHL, PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for clinical decisions, guidelines, evidence summaries, systematic reviews, and expert consensus related to fall prevention in community-dwelling elderly individuals. The methodological quality of included literature was assessed, and evidence was extracted and synthesized based on key themes.</p><p><strong>Results: </strong>A total of 3 guidelines, 1 expert consensus, and 12 systematic reviews were included. Twenty-six pieces of evidence were summarized across 8 areas: fall risk screening, fall risk assessment, exercise interventions, medication management, environmental safety, health education, psychological interventions, and multifactorial interventions.</p><p><strong>Conclusion: </strong>The best evidence for fall prevention in community-dwelling elderly individuals was summarized, providing an evidence-based foundation for community healthcare providers to implement fall prevention measures.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4033-4044"},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection and Intervention Practices Provided by Physical and Occupational Therapists in Saudi Arabia for Children with or at Risk for Cerebral Palsy.","authors":"Afnan Gmmash, Turki Aljuhani, Reem A Albesher","doi":"10.2147/JMDH.S526999","DOIUrl":"10.2147/JMDH.S526999","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate cerebral Palsy (CP) diagnosis is possible before or at the age of 5 months. However, little is known about the practice of early detection guidelines in Saudi Arabia. The objective of this study was to explore the current physical therapy (PT) and occupational therapy (OT) early detection practices for children (0-3 years) with or at risk for CP and knowledge and application of evidence-based practices (EBP) for these children.</p><p><strong>Patients and methods: </strong>A cross-sectional study using a purpose-developed electronic survey was distributed to physical and occupational therapists who work with young children with or at risk of CP. Descriptive statistics and cross-tabulations were employed to analyse the data.</p><p><strong>Results: </strong>A total of 76 participants completed the survey questions and were included in the analysis. Less than half of the patients (46%) received a diagnosis of being at risk for CP between 0 and 5 months of age. Only 16% of the participants are certified in using the Prechtl Qualitative Assessment. Seventy-eight percent of the participants provide parents with prognostic information regarding their children's diagnosis. Sixty-six percent of the providers always used goal-oriented therapy, 30% always used Neurodevelopmental Treatment, 22% always used passive intervention, and 84% always used caregiver education in their treatment. Application of constraint-induced movement therapy was significantly correlated with a number of demographic variables.</p><p><strong>Conclusion: </strong>This study showed that the majority of therapists consider EBP in evaluating and treating young children with CP. However, more attention should be directed toward training therapists to utilize sensitive tools to detect CP early, enabling them to incorporate EBP in their management plan. Although therapists follow some of the recommended interventions, many therapists still use ineffective treatments with children with CP. A national guideline is required to unify practice and illustrate the role of PT and OT in the management of CP.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4045-4058"},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplatform Agreement Between Liver Steatosis Analysis and Ultrasound-Guided Attenuation Parameter in the Evaluation of Hepatic Steatosis.","authors":"Juan Chen, Yan-Hong Hao, Yan-Jing Zhang, Jing-Jing Liu, Ping Liang, Li-Ping Liu","doi":"10.2147/JMDH.S528289","DOIUrl":"10.2147/JMDH.S528289","url":null,"abstract":"<p><strong>Objective: </strong>Liver steatosis analysis (LiSA) and the ultrasound-guided attenuation parameter (UGAP) are recently introduced commercially available techniques for the non-invasive evaluation of hepatic steatosis. This study aimed to assess the interplatform agreement between LiSA and UGAP in quantifying hepatic fat content.</p><p><strong>Methods: </strong>Individuals diagnosed with or suspected of having fatty liver disease were included in the study. The overall interplatform agreement between LiSA and UGAP was assessed. The cohort was classified into 8 groups: 4 groups based on steatosis severity (S0-S3) and 4 groups based on predominant etiologies including non-alcoholic fatty liver disease, alcoholic liver disease, drug-induced fatty liver disease, and other causes. Paired-sample <i>t</i>-tests were used to compare LiSA and UGAP values. Interplatform agreement was evaluated using Bland‒Altman analysis with 95% limits of agreement (LOAs) and intraclass correlation coefficients (ICCs). The Pearson's correlation coefficient was calculated to assess the relationship between LiSA and UGAP.</p><p><strong>Results: </strong>A cohort of 357 patients with available LiSA, UGAP, and controlled attenuation parameter measurements were included in the study. No significant differences were observed between LiSA and UGAP values (<i>p</i> > 0.05). Pearson's correlation coefficients ranged from ranged from 0.89 to 0.94 across all groups, while ICCs exceeded 0.80. Bland‒Altman analysis demonstrated slight biases between LiSA and UGAP, ranging from -6.17 to 1.97 dB/m for all groups, with 95% LOAs for mean attenuation coefficient values ranging from -40.55 to 36.09 dB/m.</p><p><strong>Conclusion: </strong>LiSA and UGAP exhibited excellent interplatform agreement and can be used interchangeably for longitudinal monitoring of patients with hepatic steatosis.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"4023-4032"},"PeriodicalIF":2.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}