HIV感染与胰岛素抵抗、糖尿病之间无遗传因果关系:双向孟德尔随机分析。

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-30 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S546669
Pengfei Liu, Qiurong Zeng
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引用次数: 0

摘要

背景:HIV感染与胰岛素抵抗以及糖尿病之间的因果关系尚不清楚。本研究利用全基因组关联研究数据和孟德尔随机化技术探讨了这些关联。方法:我们采用双向、双样本孟德尔随机分析来评估HIV感染与胰岛素抵抗、1型糖尿病、2型糖尿病和妊娠糖尿病之间的因果关系。此外,我们评估了HIV感染与糖化血红蛋白之间的关系。采用五种孟德尔随机化方法:方差逆加权法、MR-Egger法、加权中位数法、加权模态法和简单模态法。Cochran’s Q检验用于评估异质性,而MR-Egger截距检验用于评估水平多效性。灵敏度评价采用留一法。结果:HIV感染与胰岛素抵抗、1型糖尿病、2型糖尿病、妊娠糖尿病或HbA1c水平之间没有因果关系。IVW分析和其他孟德尔随机化方法的结果一致为零(p < 0.05)。反向孟德尔随机化分析支持这些无效发现。敏感性分析证实了我们结果的稳健性,没有发现显著的异质性或多效性。结论:这项孟德尔随机研究发现HIV感染与胰岛素抵抗或糖尿病之间没有明显的因果关系。与糖化血红蛋白的零关联进一步支持了这些发现。这些结果为HIV感染者胰岛素抵抗和糖尿病的发病机制提供了见解,强调了进一步探索潜在介导因素的必要性,如抗逆转录病毒治疗、炎症和肥胖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Background: The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization techniques.

Methods: We performed bidirectional, two-sample Mendelian randomization analyses to evaluate the causal links between HIV infection and insulin resistance, as well as type 1 diabetes, type 2 diabetes, and gestational diabetes. Additionally, we assessed the relationship between HIV infection and glycated hemoglobin. Five Mendelian randomization methods were employed: inverse variance weighting, MR-Egger, weighted median, weighted mode, and simple mode. Cochran's Q test was used to assess heterogeneity, while the MR-Egger intercept test evaluated horizontal pleiotropy. Sensitivity was evaluated using the leave-one-out method.

Results: No causal effects were found between HIV infection and insulin resistance, type 1 diabetes, type 2 diabetes, gestational diabetes, or HbA1c levels. IVW analysis and other Mendelian randomization methods consistently yielded null results (all p > 0.05). Reverse Mendelian randomization analyses supported these null findings. Sensitivity analyses confirmed the robustness of our results, with no significant heterogeneity or pleiotropy detected.

Conclusion: This Mendelian randomization study found no significant causal links between HIV infection and insulin resistance or diabetes mellitus. The null association with glycated hemoglobin further supports these findings. These results provide insights into the pathogenesis of insulin resistance and diabetes in individuals living with HIV, highlighting the need for further exploration of potential mediating factors, such as antiretroviral therapy, inflammation, and obesity.

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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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