Journal of Multidisciplinary Healthcare最新文献

{"title":"A Call to Action: Empowering Pharmacists in Drug-Resistant Tuberculosis Management.","authors":"Mohammed Alfaqeeh, Prayudi Santoso, Jan-Willem Alffenaar, Ivan S Pradipta","doi":"10.2147/JMDH.S517965","DOIUrl":"10.2147/JMDH.S517965","url":null,"abstract":"<p><p>Drug-resistant tuberculosis (DR-TB) continues to be a major global health threat, and while advancements in drug therapies have been made, the role of pharmacists in improving patient outcomes has not been fully optimized. This review aims to describe the types, resistance mechanisms, and management strategies of DR-TB, with a focus on discussing the critical role of pharmacists in optimizing treatment outcomes for DR-TB patients. A narrative review approach was adopted to provide an updated and evidence-based perspective. Additionally, manual review of reference lists from the retrieved articles was performed to identify additional relevant studies. The review identifies types of DR-TB, including mono-, poly-, rifampicin-, multi-, pre-extensively, and extensively-drug resistance. Resistance mechanisms are outlined, highlighting mutations in key genes, such as those involved in rifampicin and isoniazid (INH) resistance, which compromise treatment efficacy. The treatment regimens for DR-TB include the INH-R regimen, Bedaquiline, Pretomanid, and Linezolid (with or without Moxifloxacin) (BPaL(M) regimen, shorter oral regimen, and longer oral regimen, each tailored to the specific resistance pattern and patient condition. The challenges in managing DR-TB include complex treatment regimens and side effects, social barriers such as stigma and adherence issues, and system-related obstacles like limited resources and healthcare infrastructure. The review underscores pharmacists' vital yet underutilized role in addressing challenges. Pharmacists' contributions include patient counseling to improve adherence, and optimizing regimens for vulnerable populations and therapeutic drug monitoring. Addressing DR-TB requires a multifaceted approach, with pharmacists playing a critical role in its management. Their contributions are key to improving patient outcomes and overcoming the challenges associated with DR-TB management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3531-3544"},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study.","authors":"Yue-E Chen, Guo-Lian Zhao, Fei-Hu Liu","doi":"10.2147/JMDH.S516019","DOIUrl":"10.2147/JMDH.S516019","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary tuberculosis (PTB) may have an autoimmune component. However, the cause of autoimmune diseases associated with PTB remains unclear. We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB.</p><p><strong>Methods: </strong>After rigorous assessment, potential candidate SNPs for 10 AIDs and PTB were extracted from GWAS datasets. Three common MR approaches-inverse variance weighted (IVW), weighted median, and MR-Egger-were employed to assess causal relationships. To ensure the robustness of the findings, sensitivity analyses were performed to evaluate the stability of the results by estimating the heterogeneity and pleiotropy.</p><p><strong>Results: </strong>Our MR analysis indicated no discernible causal genetic connections between the seven AIDs, including rheumatoid arthritis (RA), asthma, Crohn's disease (CD), systemic lupus erythematosus (SLE), psoriasis (PsO), multiple sclerosis (MS), ankylosing spondylitis (AS), and PTB (all <i>P</i>>0.05). Interestingly, inflammatory bowel disease (IBD; OR, 0.967; 95% CI: 0.941-0.994, <i>P</i>=0.015), celiac disease (CeD; OR, 0.944; 95% CI: 0.917-0.972, <i>P</i><0.001), and primary sclerosing cholangitis (PSC; OR, 0.935; 95% CI: 0.877-0.997, <i>P</i>=0.041) were significantly associated with a decreased risk of PTB. The sensitivity analyses confirmed the robustness of the results.</p><p><strong>Conclusion: </strong>Our MR observations collectively highlight that genetically predicted IBD, CeD, and PSC may be protective factors against PTB. However, there was no evidence of causal ramifications between the other seven AIDs (RA, asthma, CD, SLE, PsO, MS, and AS) and PTB, implying that unmeasured confounders or shared genetic structures may be the cause of the reported epidemiological associations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3519-3530"},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a Co-Designed Implementation Enhancement Plan to Increase the Adoption of a Digital Fall Prevention Platform: A Non-Randomized Pre-Post Interventional Study.","authors":"Alana Delaforce, Jane Li, Philippa Niven, Emma Maddock, Melisa Grujovski, Michael J Fahy, Norman M Good, Rajiv Jayasena","doi":"10.2147/JMDH.S529247","DOIUrl":"10.2147/JMDH.S529247","url":null,"abstract":"<p><strong>Background: </strong>Falls are a major cause of hospital acquired complications and inpatient harm. Interventions to prevent falls exist, but it is unclear which are most effective and what implementation strategies best support their use. This study sought to ascertain the impact of a co-designed implementation enhancement plan on the adoption and effect of a digital fall prevention platform in a new hospital.</p><p><strong>Methods: </strong>A non-randomized pre-post interventional study using multi-methods. A bespoke survey as well as descriptive and inferential statistical analysis of hospital administrative data and were used to identify the impact on: (1) adoption of the system and (2) the rate of falls.</p><p><strong>Results: </strong>The co-design implementation enhancement plan successfully improved the adoption of some key platform functions, most importantly, a 39% increase (<i>p</i> = 0.04) in setting a patient as having a high risk of falling on the staff station console. There were also improvements in staff response times, satisfaction and perceptions of the fall prevention platform. A risk reduction in falls per 1000 bed days was observed among cognitively intact patients post implementation enhancement plan, however, this difference was not statistically significant (OR = 0.97 95% CI [0.78,1.22] <i>p</i> = 0.77).</p><p><strong>Conclusion: </strong>The co-designed implementation enhancement plan improved uptake of the platform and is likely to be effective for other similar interventions. The platform shows the potential to reduce falls among cognitively intact patients, but longer periods of observation and a larger sample are needed to confirm the effect. Aside from falls, a reduction in nurse response time is likely to improve patient care and experience.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3507-3518"},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization.","authors":"Huifang Liu, Yisong Yao, Yujuan Yang, Jianwei Wang, Jingyi Yu, Xinjun Xu, Xianghuang Luo, Yu Zhang, Xicheng Song","doi":"10.2147/JMDH.S515745","DOIUrl":"10.2147/JMDH.S515745","url":null,"abstract":"<p><strong>Introduction: </strong>To elucidate the currently unknown relationship between chronic lung diseases (CLDs) and depressive symptoms among older adults.</p><p><strong>Methods: </strong>A total of 8079 older adults from China Longitudinal Aging Social Survey (CLASS) and 1119 individuals from a Sichuan Province cohort were included in this study. We used regression analysis and propensity score matching (PSM) to assess the association between CLDs and depressive symptoms among older adults, while the causal relationship was assessed using Mendelian randomization (MR). Our sensitivity analyses included heterogeneity tests, tests of multiple validity, and leave-one-out tests. A two-way mediation analysis was also used to assess the mediating role of basic activities of daily living (BADL) between CLDs and depressive symptoms.</p><p><strong>Results: </strong>In this cross-sectional study, we found that depressive symptoms significantly (<i>P</i> < 0.001) increased the risk of CLDs (β = 0.047). The robustness test showed that there were significant association between CLDs and depressive symptoms (β = 0.220, <i>P</i> < 0.001), Qi depression constitution (β = 8.564, <i>P</i> < 0.001). This finding was also confirmed through robustness tests using different PSM methods. The results of the inverse-variance weighting (IVW) analysis showed that depression increased the risk of idiopathic pulmonary fibrosis and asthma, with Beta coefficients of 2.822 [standard error (SE) = 1.087; <i>P</i> = 0.009] and -1.090 (SE = 0.491; <i>P</i> = 0.027), accordingly. The results of the IVW analysis showed that idiopathic pulmonary fibrosis and asthma increased the risk of depression, with Beta coefficients of 2.822 [standard error (SE) = 1.087; <i>P</i> = 0.009] and -1.559 (SE = 0.633; <i>P</i> = 0.013). The sensitivity analysis results confirmed the reliability of this conclusion. The mediating role of BADL was observed from depressive symptoms to CLDs.</p><p><strong>Conclusion: </strong>Depressive symptoms are associated with an increased risk of CLDs, reduced BADL promote the risk of CLDs in older adults with depressive symptoms, but the underlying pathological mechanism still needs to be clarified in future research.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3465-3475"},"PeriodicalIF":2.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Factors Affecting Quality of Life (QoL) in Middle-Aged Stroke Patients (Under 65 Years Old) in the Rehabilitation Phase: Multivariate Regression Analysis.","authors":"Valentina Belinda M Lumbantobing, Mukti Priastomo, Cecep Eli Kosasih, Putri Rhamelani, Kusnandar Anggadiredja, I Ketut Adnyana","doi":"10.2147/JMDH.S504851","DOIUrl":"10.2147/JMDH.S504851","url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed factors influencing the quality of life (QoL) in stroke patients during the rehabilitation phase so that rehabilitation professionals, caregivers, and stroke patients can pay attention to all aspects that contribute significantly to a better QoL and can design appropriate interventions to improve patient welfare and support a more significant recovery process.</p><p><strong>Patients and methods: </strong>A non-experimental quantitative approach with a cross-sectional design was conducted with 76 adult stroke patients in the rehabilitation phase. Data were collected using an interval-scale paper-based questionnaire and analyzed using univariate analysis techniques and multivariate regression analysis.</p><p><strong>Results: </strong>The results showed that social support, sleep quality, self-esteem, hardiness, spirituality, and psychological well-being affected patients' QoL in all domains (P = 0.000). More specifically, the physical domain was significantly affected by sleep quality (P = 0.000), spirituality (P = 0.004), and psychological well-being (P = 0.000). The psychological domain was significantly affected by social support (P = 0.000), sleep quality (P = 0.017), hardiness (P = 0.000), and spirituality (P = 0.007). The social domain was significantly influenced by social support (P = 0.002), sleep quality (P = 0.044), and self-esteem (P = 0.000). Finally, the environmental domain was significantly influenced by social support (P = 0.002) and self-esteem (P = 0.000).</p><p><strong>Conclusion: </strong>The success of stroke patient recovery in the rehabilitation phase is marked by the goodness of all domains of QoL. This study obtained the analysis result of specific factors affecting each domain in QoL. Therefore, patients, families, nurses, and other health care providers have a crucial role in efforts to create a better QoL in stroke patients in the rehabilitation phase by considering the factors that have the most significant influence.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3477-3491"},"PeriodicalIF":2.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Combined Dietary and Exercise Intervention in Pediatric Obesity and Its Impact on Anthropometric Measurements and Blood Lipid Parameters.","authors":"Yang Nie, Fei Xiong, Hong Wang, Fengqiong Yang, Jianxin Chen","doi":"10.2147/JMDH.S521927","DOIUrl":"10.2147/JMDH.S521927","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of a combined dietary and exercise intervention on anthropometric measurements and blood lipid profiles in obese children, and to provide evidence-based support for pediatric obesity management.</p><p><strong>Methods: </strong>This retrospective study included 130 obese children who underwent routine health examinations and interventions between January 2020 and October 2023. Participants were divided into two groups: the control group received health education only, while the observation group received additional dietary and exercise interventions. Pre- and post-intervention changes in anthropometric indicators, body fat levels, lipid profiles, inflammatory markers, physical activity levels, and parental satisfaction were assessed.</p><p><strong>Results: </strong>Baseline characteristics were similar between groups (P > 0.05). After intervention, the observation group showed significantly lower body weight, BMI, waist-to-hip ratio, body fat percentage, visceral fat area, and lipid levels (TG, TC, LDL-C), along with higher basal metabolic rate (P < 0.05). Physical activity increased and sedentary time decreased significantly in the observation group (P < 0.001). Additionally, inflammatory markers (IL-6, IL-8, TNF-α) were markedly reduced in the observation group (P < 0.05), and parental satisfaction was significantly higher compared to the control group.</p><p><strong>Conclusion: </strong>A combined dietary and exercise intervention significantly improves body composition, lipid metabolism, physical activity levels, and inflammatory status in obese children. This comprehensive model may be an effective, non-pharmacological strategy for promoting healthy growth and managing childhood obesity.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3455-3464"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 Patients During the First Wave of Pandemic.","authors":"Hossam Gad, Mohamed A Mahmoud, Mohamed Antar, Ahmed Sayed Ahmed, Krzysztof Laudanski","doi":"10.2147/JMDH.S515244","DOIUrl":"10.2147/JMDH.S515244","url":null,"abstract":"<p><strong>Purpose: </strong>Recent discoveries have pointed to the role of IGFALS immunological response to viral challenges, potentially leading to the emergence of a cytokine storm. Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence.</p><p><strong>Patients and methods: </strong>We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (t_adm), at 48 hours (t_48hrs), 7 days (t_7d), and after discharge from hospital (t_long). IGFALS and IGF-1 in serum were measured to assess dynamics of the illness and compared against non-specific inflammatory (C-reactive protein, IL-6) markers. Serum titers of IgG against proteins S and N assessed specific viral responses. Serum HMGB-1 was measured to assess level of necrosis. Demographic and clinical data were collected using electronic health records (EHR). Survival was determined at six months from admission.</p><p><strong>Results: </strong>No difference between serum IGFALS and IGF-1 levels was seen across the studied time points. IGFALS_adm showed significant positive correlations with IGFALS_48hrs (<i>r²</i> =0.18; <i>p</i><0.001), IGFALS_7d (<i>r²=</i>0.19; <i>p</i>=0.004), and IGFALS_long (<i>r² =</i> 0.23; <i>p</i>=0.045). IGFALS correlated negatively with IGF-1 but positively with growth hormone. IGFALS_adm showed significant inverse correlations with serum levels of HMGB1_adm (<i>r²=</i>0.26; <i>p =</i> <0.001) and t_48hr (<i>r² =</i> 0.27; <i>p</i><0.001). A significant correlation in the case of IGFALS_48hrs and CRP_48hrs (<i>r² =</i> 0.09, <i>p</i> = 0.021), IGFALS_long and CRP_long (<i>r² =</i> 0.271, <i>p</i>=0.039) was seen. Similar correlations were seen at 48 hours of sampling time for IL-6 (<i>r² =</i> 0.14, <i>p</i>=0.006). In terms of specific antiviral response, we observed that serum IGFALS_adm demonstrated correlation levels of serum IgG_adm (<i>r² =</i> 0.09, <i>p</i>=0.024). A positive correlation was found between length of stay in hospital or ICU and serum IGFALS_48hrs.</p><p><strong>Conclusion: </strong>Though IGFALS serum levels did not change significantly during SARS-CoV-2 infection, we observed correlations with markers of tissue destruction, C-reactive protein, IL-6, and length of hospital stay.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3447-3453"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Themes Have to Be Considered in the Change Process Within Healthcare Organizations: Critical Analysis Review.","authors":"Hatem H Alsaqqa","doi":"10.2147/JMDH.S514080","DOIUrl":"10.2147/JMDH.S514080","url":null,"abstract":"<p><p>This review is intended to scrutinize different articles' types and determine a suitable process, model or framework for successful change in healthcare organizations. An integrative review of the literature was conducted. The search strategy began with three electronic databases (EBSCOhost, Google Scholar and PubMed). Considering the inclusion criteria, published articles that examined the change process within the healthcare organizations in the timeframe between 2000 and 2023 were chosen. Results extraction and analysis were completed on all the included articles. The final sample for this review comprised 19 studies. Based on common meanings and vital issues, 8 main themes contributing to change in healthcare organizations were integrated and grouped into four main categories (process dimensions), two adjunct factors (strategic dimensions) and one mediating tool and a result category. The four main categories are readiness to change, team-building, tangible and intangible variables' characteristics and the two adjunct factors are the metaphor design and time perspective. In addition to technology as a mediating role for change and the scale of the change as a resulted outcome. In general, collections that emerged in this study could be useful for framing initiatives to arouse organizational change in healthcare. However, little is known about the relative significance of each acknowledged factor within the change process in healthcare organizations. Various methodological research is recommended for narrowing this gap. Before beginning the change process, ongoing studies should focus on the psychological features of organizational scales for healthcare contexts.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3433-3446"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemiarthroplasties via Posterior Trochanter Osteotomy for Treating Femoral Neck Fractures in Post-Cerebrovascular Disease.","authors":"Ying-Ao Jia, Li-Na Qiao, Zhi-Bin Liu, Liang Xue, Wei-Ming Bi, Meng-Fei Chen, Kai Kang, Fei Wang","doi":"10.2147/JMDH.S515576","DOIUrl":"10.2147/JMDH.S515576","url":null,"abstract":"<p><strong>Objective: </strong>The study investigated to examine the clinical outcomes of hemiarthroplasties using posterior femoral trochanter osteotomy for the treatment of femoral neck fractures in patients at the sequelae stage of cerebrovascular disease.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the data of 53 patients who had been admitted to the Department of Orthopedics at Yan'an University Affiliated Hospital between May 2020 and May 2023. These patients had been diagnosed with femoral neck fractures and concurrent muscle weakness at the sequelae stage of cerebrovascular disease. The patients were divided into two groups: the osteotomy group (20 cases), which underwent hemiarthroplasties via an L osteotomy of the posterior femoral trochanter, and the conventional group (33 cases), which received hemiarthroplasties through the posterolateral approach of the greater trochanter. The two groups were compared on various parameters, including incision length, operation duration, intraoperative blood loss, postoperative drainage, blood transfusion rates, length of hospitalization, early mobilization post-surgery, hip joint function scores at follow-up visits (3 and 12 months), and the rate of postoperative dislocation of the femoral head.</p><p><strong>Results: </strong>No significant differences were observed between the two groups regarding incision length (<i>P</i>=0.06), operation duration (<i>P</i>=0.284), intraoperative blood loss (<i>P</i>=0.925), Blood transfusion rate (P=0.489), postoperative drainage (<i>P</i>=0.831) and length of hospital stay (<i>P</i>=0.341). However, the early mobilization time following surgery was shorter in the osteotomy group compared to the conventional group (<i>P</i><0.001). Additionally, the Harris hip joint function scores for the osteotomy group were significantly higher than those for the conventional group at both the 3- and 12-month postoperative assessments (<i>P=</i>0.003, <i>P=</i>0.004, respectively). The dislocation rate of the femoral head in the osteotomy group was lower than that in the conventional group with no statistical significance difference (<i>P</i>=0.521).</p><p><strong>Conclusion: </strong>The use of hemiarthroplasties via posterior femoral trochanter osteotomy demonstrates favorable clinical outcomes in the treatment of femoral neck fractures.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3391-3401"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative and Quantitative Assessment of T2-Weighted Imaging Signal Variations in Prostate MRI Following Different Abstinence Periods: A Study in Young Healthy Men.","authors":"Wenjun Ma, Baoming Ren, Yanjun Gao, Weixian Bai","doi":"10.2147/JMDH.S517266","DOIUrl":"10.2147/JMDH.S517266","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the impact of an abstinence period on the image quality of high-field prostate magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Male patients who underwent prostate MRI at Xi'an No.3 hospital between November 2021 and November 2022 were included in this study. The patients were divided into two groups based on whether they had ejaculated within three days prior to the MRI examination. Two radiologists assessed the boundary sharpness of the peripheral zone (PZ) and central gland (CG) using a double-blind 3-Point Likert scale. Regions of interest (ROIs) were marked bilaterally on the PZ and CG in sagittal T2-weighted images (T2WI). The signal intensity (SI) of the ROIs was measured, and the signal intensity ratio (SIR) was subsequently calculated. The Wilcoxon rank-sum test and independent samples <i>t</i>-test were employed to compare differences between the two groups.</p><p><strong>Results: </strong>A total of 50 young male patients participated in the study, with 20 patients having an abstinence period of more than 3 days and 30 patients having an abstinence period of 3 days or less. Qualitative analysis revealed that the prostate structures were more easily identifiable in the abstinence group compared to the ejaculation group (<i>P</i> ≤ 0.05). Quantitative analysis showed that the SIR of the PZ and CG was lower in the ejaculation group than in the abstinence group (<i>P</i> ≤ 0.05 for both), with a particularly significant difference observed in the peripheral zone.</p><p><strong>Conclusion: </strong>To obtain more accurate results in prostate MRI examinations, it is recommended that patients abstain from sexual activity for at least 3 days prior to the examination.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3403-3409"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}