Journal of Multidisciplinary Healthcare最新文献

{"title":"Development of an Evidence-Based and Theory-Informed Self-Management Intervention for People with Lipoedema: An Intervention Mapping Study.","authors":"Lise Maren Kloosterman, Ad Hendrickx, Francine Schneider, Rienk Dekker, Harriët Jager-Wittenaar, Aldo Scafoglieri","doi":"10.2147/JMDH.S536084","DOIUrl":"10.2147/JMDH.S536084","url":null,"abstract":"<p><strong>Background: </strong>The etiology of lipoedema remains unclear, making diagnosis and treatment challenging. Current treatment primarily consists of general lifestyle recommendations, with effective self-management being essential for integrating these recommendations into daily life. However, no self-management interventions currently address the unique needs of people with lipoedema. This study aimed to develop an evidence-based, theory-informed intervention to enhance self-management in people with lipoedema using the Intervention Mapping (IM) approach.</p><p><strong>Methods: </strong>Following the first four steps of the IM approach, this study used a participatory methodology involving stakeholders, empirical data, and theory. Steps included: 1) needs assessment; 2) identification of outcomes, performance objectives, and change objectives; 3) selection of behavioural change methods; and 4) development of program components.</p><p><strong>Results: </strong>The resulting intervention includes a program for people with lipoedema and a training program for healthcare professionals (HCPs). The intervention aims to empower patients to engage in self-management and equip HCPs to provide effective support. Key determinants targeted include self-efficacy, self-regulation skills, knowledge, attitudes, and social facilitation. The program for people with lipoedema consists of seven themes aligned with self-management behaviours and is delivered through 19 sessions: seven one-on-one sessions, one session involving supportive individuals, and 11 group sessions. The program for HCPs is delivered through six group sessions, each focusing on the core skills HCPs need to effectively deliver self-management support to their patients.</p><p><strong>Conclusion: </strong>The IM approach effectively guided a systematic, transparent, and reproducible development process. Grounded in established theories and behavioural change methods, the intervention provides a strong foundation for implementation and evaluation among people with lipoedema. The fifth and sixth steps of IM are considered future priorities.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6151-6165"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Pulmonary Function Testing in Differentiating Asthma From COPD: Trends, Impact, and Emerging Research Areas.","authors":"Noor Al Khathlan, Lama Omar Badghish, Hanin Hamed Alrehaili, Khalid Hamoud Olayan Al Luhaybi, Moayed Abdullah Alnakhli, Abdulhadi Jameel Alotaibi","doi":"10.2147/JMDH.S539721","DOIUrl":"10.2147/JMDH.S539721","url":null,"abstract":"<p><strong>Background: </strong>Distinguishing between asthma and chronic obstructive pulmonary disease (COPD) remains a clinical challenge due to overlapping symptoms and pulmonary function test (PFT) results. Accurate differentiation is crucial for effective treatment and optimal patient care. This study employs bibliometric analysis to assess research trends, impact, and emerging areas in the use of PFTs for differentiating asthma from COPD.</p><p><strong>Methods: </strong>A systematic search was conducted in the Web of Science Core Collection, including both asthma- and COPD-related terms to reflect clinical overlap, identifying publications from 1989 to November 2024. Data were analyzed using VOSviewer, CiteSpace, Excel, and Biblioshiny to evaluate publication trends, influential authors, key research themes, and international collaboration networks.</p><p><strong>Results: </strong>The analysis included 241 original research and review articles. Research activity increased significantly after 2006, peaking in 2022. The United States and England were the leading contributors, with major academic institutions and AstraZeneca playing key roles. Keywords such as \"spirometry\", \"diagnosis\", and \"bronchodilator response\" emerged as major research trends. Co-citation analysis identified the European Respiratory Journal as the most influential source.</p><p><strong>Conclusion: </strong>Bibliometric analysis highlights a growing body of research emphasizing the role of PFTs in differentiating asthma from COPD. While spirometry remains the gold standard, recent trends show increasing interest in novel diagnostic approaches. Further studies are needed to refine diagnostic criteria and improve clinical decision-making. Our findings underscore the novelty of this bibliometric analysis in mapping global research dynamics and highlight potential clinical implications for refining diagnostic strategies in asthma and COPD.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6187-6203"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Situation and Future Trends of Ergothioneine in Biology and Medical Research: A Bibliometric Analysis.","authors":"Yixian Fu, Haiying Guan, Mingna Yu, Ping Jiang, Xiaojun He, Jidan Bao, Binjie Zhang, Yan Li","doi":"10.2147/JMDH.S547548","DOIUrl":"10.2147/JMDH.S547548","url":null,"abstract":"<p><strong>Background: </strong>Ergothioneine (EGT) is a natural antioxidant with multiple cellular protective properties. Recently, due to the improvement of production efficiency, EGT-related products have been more widely used. This paper studies the present situation of global research trends and hotspots of EGT to better grasp the direction of EGT research in biology and medical.</p><p><strong>Methods: </strong>We searched for relevant literature on EGT in the Web of Science Core Collection (WOSCC) and SciFinder databases on August 16, 2025. CiteSpace, VOSviewer, Tableau Desktop, Microsoft Excel, Bibliometrix program package and Biorender software are used for statistical analysis and visualisation.</p><p><strong>Results: </strong>A total of 800 articles were collected. It is found that the average growth rate of EGT's publications in biology and medicine from 1996 to 2025 was 17.33%. Based on the statistical results by country/region, it is evident that the primary focal areas of research activity within this domain exhibit concentrated distribution across the Americas, Asia, and Europe. Among the top ten authors in terms of publication volume, six are from Asia, three are from Poland in Europe, and one is from the United States (USA) in the Americas. The highest H-index ranking author is Halliwell B (169).</p><p><strong>Conclusion: </strong>Based on the keyword visualisation results, the current research hotspots are mainly divided into three clusters: 1) The absorption, distribution, anti-inflammatory and antioxidant biological molecular mechanisms of EGT in vivo. 2) The impact of EGT's antioxidant and anti-inflammatory effects on various diseases; 3) The source of EGT, the antioxidant potential of edible fungi in vitro, and its influencing factors. At present, research on EGT in biology and medicine mainly focuses on basic theories, so we believe that clinical trial research will become a hot trend in the future.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6127-6149"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncolytic Virotherapy for Glioma: A Bibliometric Roadmap for Multidisciplinary Clinical and Research Strategies.","authors":"Shichao Liu, Risheng Liang","doi":"10.2147/JMDH.S557248","DOIUrl":"10.2147/JMDH.S557248","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma (GBM) remains the most lethal primary brain tumor with a dismal prognosis despite standard therapies. Oncolytic viruses (OVs), which selectively destroy cancer cells and stimulate anti-tumor immunity, have emerged as a promising therapeutic strategy. This study aims to systematically map the global research landscape, knowledge structure, and evolutionary trends of OV therapy for gliomas.</p><p><strong>Methods: </strong>Publications from 2009 to 2025 were retrieved from the Web of Science Core Collection (WOSCC). Bibliometric analysis and knowledge mapping were conducted using CiteSpace and RStudio to analyze collaboration networks, co-citation patterns, and keyword evolution.</p><p><strong>Results: </strong>A total of 559 publications were analyzed. The annual output has grown exponentially since 2020, with the USA and China being the most productive countries. A clear paradigm shift was identified, moving from early research focused on direct oncolysis by viral vectors like Herpes Simplex Virus to a current emphasis on immuno-virotherapy. Recent hotspots are dominated by keywords such as immunotherapy, combination, tumor microenvironment, and T-cells, indicating a research trajectory towards complex, synergistic treatment strategies. Harvard University and Brigham and Women's Hospital are the leading institutions in this field.</p><p><strong>Conclusion: </strong>The research field of oncolytic virotherapy for gliomas is rapidly advancing, with a clear evolution towards sophisticated combination immunotherapies. This analysis provides a comprehensive roadmap of the field's knowledge base and identifies key future directions, including overcoming delivery barriers and developing personalized treatment protocols, to accelerate the clinical translation of this promising therapy.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6167-6185"},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Six Decades of Research and Innovation in Cardiac Electrophysiology: A Historical Scientometrics Analysis.","authors":"Oscar Andrés Alzate Mejía, Foday Tejan Mansaray, Ornella Fiorillo-Moreno, Johana Patricia Galván-Barrios","doi":"10.2147/JMDH.S538851","DOIUrl":"10.2147/JMDH.S538851","url":null,"abstract":"<p><strong>Background: </strong>Cardiac electrophysiology research has expanded rapidly, yet its global distribution, collaborative dynamics, and thematic evolution have never been quantified across the full history of the field. Mapping these patterns is crucial for guiding funding and designing impactful studies.</p><p><strong>Methods: </strong>A scientometrics analysis was conducted on articles indexed in Scopus, Web of Science, and PubMed (1959-2025). After screening, 3766 peer-reviewed papers were analyzed. Publication trends, citation-based indicators (h-index, which reflects productivity and impact; g-index, which highlights highly cited work; and m-index, which adjusts for time), journal quartiles, World Bank income-levels, and WHO regions were quantified. Co-authorship networks mapped institutional and national partnerships, while text-mining tracked keyword trajectories to identify emerging research fronts.</p><p><strong>Results: </strong>Annual publications increased from 3 in 1959 to 268 in 2021. Articles averaged six co-authors, with 25% showing international collaboration. High-income countries produced 86.7% of output and dominated journals' impact (mean h-index = 155). In contrast, lower-middle-income nations contributed only 1.9%. The University of California and the United States were central collaboration hubs, while Africa and Latin America remained peripheral. Keyword analysis showed a shift from pharmacology and in-vitro biophysics to newer areas such as implantable devices, artificial intelligence-guided risk scoring, and stem cell-based models. Emerging concepts such as Bayes theorem (for probabilistic modeling) and quantitative trait locus (for linking genetics to arrhythmia risk) are beginning to appear, though still scarcely represented. Cross-continental papers received the highest citation density.</p><p><strong>Conclusion: </strong>Cardiac electrophysiology knowledge is concentrated in high-income regions and in teams with strong collaboration. This map highlights geographic blind spots and emerging themes, offering a practical guide for building north-south consortia, focusing on neglected pathologies, and investing in artificial intelligence and stem-cell-based strategies likely to drive the next breakthroughs.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6103-6114"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Magnetic Resonance Imaging and Radiomics in Brucella Spondylitis: Diagnostic Applications and Differential Diagnosis.","authors":"Xiaopeng Wu, Ruijun Wang","doi":"10.2147/JMDH.S536880","DOIUrl":"10.2147/JMDH.S536880","url":null,"abstract":"<p><p>Brucella spondylitis (BS) is one of the most common and serious complications of brucellosis, with insidious clinical manifestations and lack of specificity, which often delay the disease and cause a series of adverse consequences such as multi-organ involvement and dysfunction in severe cases. Due to the lag of laboratory-related laboratory tests and pathological examinations and the many factors that interfere with the confirmed results, the diagnosis and treatment of BS are affected. Magnetic resonance imaging (MRI) is particularly important in the diagnosis of BS and in the assessment of disease progression, treatment efficacy, and prognosis through a refined response to the structure and function of diseased tissues due to its multiparametric imaging and good tissue resolution. Radiomics, as an emerging means to quantitatively analyze image information and provide disease diagnosis and treatment assistance, is gradually showing its important value, by screening the omics features of the imaging affected vertebral bodies, constructing a diagnostic model based on machine learning, and conducting research on the diagnosis and differential diagnosis of BS.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6091-6101"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Driven Development of the Chalerm App: A Mobile Health Application for Chronic Disease Management and Elderly Care in Southern Thailand.","authors":"Akkachai Lekapol, Buppha Raksanam, Wittaya Sornkaew, Phiman Thirarattanasunthon, Worayuth Nak-Ai, Abdulloh Bunmalert, Rattana Kraikaew, Benjawan Chuaykaew, Lafi Munira, Anwar Mallongi","doi":"10.2147/JMDH.S541792","DOIUrl":"10.2147/JMDH.S541792","url":null,"abstract":"<p><strong>Background: </strong>Mobile health (mHealth) applications have the potential to improve chronic disease management and healthcare support for older adults. However, their development and contextual adaptation in rural communities remain limited. This study aimed to develop and evaluate the Chalerm App, a mobile health application designed to strengthen chronic disease management, service accessibility, and caregiver support among older adults in Southern Thailand.</p><p><strong>Methods: </strong>A participatory action research (PAR) design was conducted at a Health Promoting Hospital in Nakhon Si Thammarat Province, Southern Thailand, from March to August 2024. The Chalerm App was developed on Android- and iOS-based platforms through collaboration with software developers, health professionals, and community stakeholders. The study comprised three phases. In Phase 1 (Situation analysis), 223 participants-including 30 elderly individuals, 10 health staff, 7 community leaders, and 176 community members-were recruited using stratified random sampling and participated in interviews and focus groups to identify care gaps. In Phase 2 (Mobile Health Application Development), 30 participants-including 10 health staff, 7 community leaders, and 13 elderly individuals with their caregivers-engaged in co-designing the app. In Phase 3 (Usability and Effectiveness Assessment), 30 elderly individuals and caregivers, recruited via simple random sampling, evaluated the app using a validated researcher-developed tool.</p><p><strong>Results: </strong>In Phase 1, the main challenges identified included the high prevalence of chronic diseases (hypertension, diabetes, and degenerative joint disease), psychological issues such as loneliness and depression, limited access to healthcare due to geographical and workforce constraints, and low levels of digital literacy. In Phase 2, the Chalerm App was developed with four key functions: (1) Remote Appointment Scheduling, (2) Demographic Information Display, (3) Home Navigation Support, and (4) Health Knowledge Repository. In Phase 3, the evaluation demonstrated that the app significantly exceeded the quality benchmark (p < 0.001), showing notable improvements in elderly healthcare performance, perceptions of the innovation, and the overall quality of care services (p < 0.001).</p><p><strong>Conclusion: </strong>The Chalerm App improved chronic disease management, service accessibility, and caregiver support for older adults in a rural Thai community. Findings suggest that community-driven mHealth solutions can reduce healthcare inequities in resource-limited settings with potential applicability to similar contexts.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6115-6125"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Nutritional Management on Postoperative Recovery Outcomes in Prostate Cancer Patients Undergoing Radical Prostatectomy: A Retrospective Study.","authors":"Guoyu Du, Yi Zhang","doi":"10.2147/JMDH.S549544","DOIUrl":"10.2147/JMDH.S549544","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer remains a prevalent malignant tumor among males globally, while the impact of perioperative nutritional management on prognosis remains poorly defined. This study aims to investigate the management efficacy of dietary supplement (nutrient) administration in prostate cancer patients following radical prostatectomy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 70 prostate cancer patients who underwent radical prostatectomy at our institution between March 2022 and January 2024. Participants were divided into two groups based on distinct perioperative management protocols: the control group received conventional management, while the observation group received targeted dietary supplements (nutrients) in addition to the conventional regimen. Comparative analyses were performed on clinical indicators, recovery parameters, and adverse symptom incidence between groups to evaluate the role of nutrient supplementation in perioperative management.</p><p><strong>Results: </strong>Baseline characteristics demonstrated comparability between groups (P>0.05). The observation group exhibited significantly shorter postoperative drainage tube removal duration and hospital stay compared to controls (P<0.05). First postoperative bowel movement time and independent ambulation recovery time were also reduced in the observation group (P<0.05). No statistically significant difference in BMI levels was observed between groups (P>0.05). Serum albumin levels measured at preoperative day 1, and postoperative days 1 and 3 were significantly elevated in the observation group (P<0.05). Postoperative day 3 serum immunoglobulin levels (IgG, IgA, IgM) showed marked increases in the observation group (P<0.05). The observation group reported significantly fewer gastrointestinal symptoms including thirst, hunger, and nausea compared to controls (P<0.05).</p><p><strong>Conclusion: </strong>Dietary supplement (nutrient) administration may improve perioperative nutritional parameters, enhance systemic immunity, facilitate postoperative rehabilitation, and alleviate gastrointestinal symptoms in prostate cancer patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6079-6090"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease.","authors":"Dong-Hong Huang, Yue-Ling Zhang, Sheng-Liang Shi, Tian-Jia Liang, Jun-Jian Chen, Guo-Qiao Li, Zhao-De Chen","doi":"10.2147/JMDH.S533723","DOIUrl":"10.2147/JMDH.S533723","url":null,"abstract":"<p><strong>Objective: </strong>Emerging evidence suggests a genetic link between immune-related diseases and Alzheimer's disease (AD), though the underlying mechanisms remain unclear. This Mendelian randomization (MR) study investigates the genetic relationship between six immune-related diseases-type 1 diabetes (T1DM), systemic lupus erythematosus (SLE), asthma, myasthenia gravis (MG), endometriosis, and idiopathic thrombocytopenic purpura (ITP)-and AD.</p><p><strong>Methods: </strong>Summary-level data were obtained from publicly available genome-wide association studies (GWAS) for the six immune-related diseases and AD. MR-estimation was conducted utilizing the inverse variance weighted (IVW), MR-Egger, and WM methods. Additionally, sensitivity analyses were performed, encompassing Cochran's Q test, MR-Egger intercept, MR-Pleiotropy residual sum and outlier (MR-PRESSO) method, leave-one-out analysis, and funnel plots.</p><p><strong>Results: </strong>A statistically significant association was identified between asthma and a slightly lower risk of AD (odds ratio [OR] = 0.996, 95% CI: 0.994-0.997, P = 0.001); however, the effect size was negligible and likely lacks clinical significance. No significant genetic associations were found between T1DM, SLE, MG, endometriosis, or ITP and AD. Reverse MR analyses indicated no evidence of reverse causality from AD to these immune-related conditions.</p><p><strong>Conclusion: </strong>Although a nominal association was observed, this MR analysis does not support a causal relationship between genetic liability to asthma and Alzheimer's disease. This relationship underscores the specificity of the association, as no causal connections were found between other studied immune-related diseases conditions-T1DM, SLE, MG, endometriosis, and ITP-and AD.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6063-6077"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses.","authors":"Ping Li, Tingting Qiu, Lvjie Xu, Liming Wu, Sixuan Zhao, Xiao Liu, Yiting Yang, Jiawei Wang","doi":"10.2147/JMDH.S539951","DOIUrl":"10.2147/JMDH.S539951","url":null,"abstract":"<p><strong>Purpose: </strong>To explore causal relationships between kidney function and the risk of senile cataract and primary open-angle glaucoma (POAG) using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Summary statistics for kidney function traits were obtained from the CKDGen consortium to identify genetically predicted chronic kidney disease (CKD), estimated glomerular filtration rate (eGFR), and urinary albumin-to-creatinine ratio (UACR). Data on senile cataract and POAG were sourced from the FinnGen consortium. Initially, we applied the bidirectional univariate MR method (UVMR) to assess the causal effects between kidney function and the risk of senile cataract and POAG. Inverse-variance weighted method (IVW) served as the primary analysis, supplemented by weighted median and MR-Egger methods. Subsequently, multivariable MR (MVMR) was conducted to validate significant causal associations identified in UVMR. Bioinformatics analyses were conducted through enrichment analysis and a protein-protein interaction network to elucidate potential molecular mechanisms.</p><p><strong>Results: </strong>UVMR showed that higher genetically predicted UACR was associated with an increased risk of senile cataract (IVW OR = 1.29, 95% CI: 1.05 to 1.58, P = 0.016), but no reverse causality was observed. No causal associations were found between CKD or eGFR and cataract, or between kidney function and POAG. MVMR further indicated that the associations of UACR with senile cataract remained robust after adjusting for potential confounders, including eGFR, telomere length, diabetes, hypertension, and smoking. Enrichment analysis highlighted significant associations with retinol metabolism, xenobiotic metabolism by cytochrome P450, and glycine/serine/threonine metabolism pathways.</p><p><strong>Conclusion: </strong>Our results suggested that kidney damage, as measured by UACR, causally increased the risk of cataract, but no causal relationship was found between kidney function and POAG. This study underscores the importance of regular ophthalmic screening for individuals with albuminuria.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6051-6061"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}