{"title":"Oncolytic Virotherapy for Glioma: A Bibliometric Roadmap for Multidisciplinary Clinical and Research Strategies.","authors":"Shichao Liu, Risheng Liang","doi":"10.2147/JMDH.S557248","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma (GBM) remains the most lethal primary brain tumor with a dismal prognosis despite standard therapies. Oncolytic viruses (OVs), which selectively destroy cancer cells and stimulate anti-tumor immunity, have emerged as a promising therapeutic strategy. This study aims to systematically map the global research landscape, knowledge structure, and evolutionary trends of OV therapy for gliomas.</p><p><strong>Methods: </strong>Publications from 2009 to 2025 were retrieved from the Web of Science Core Collection (WOSCC). Bibliometric analysis and knowledge mapping were conducted using CiteSpace and RStudio to analyze collaboration networks, co-citation patterns, and keyword evolution.</p><p><strong>Results: </strong>A total of 559 publications were analyzed. The annual output has grown exponentially since 2020, with the USA and China being the most productive countries. A clear paradigm shift was identified, moving from early research focused on direct oncolysis by viral vectors like Herpes Simplex Virus to a current emphasis on immuno-virotherapy. Recent hotspots are dominated by keywords such as immunotherapy, combination, tumor microenvironment, and T-cells, indicating a research trajectory towards complex, synergistic treatment strategies. Harvard University and Brigham and Women's Hospital are the leading institutions in this field.</p><p><strong>Conclusion: </strong>The research field of oncolytic virotherapy for gliomas is rapidly advancing, with a clear evolution towards sophisticated combination immunotherapies. This analysis provides a comprehensive roadmap of the field's knowledge base and identifies key future directions, including overcoming delivery barriers and developing personalized treatment protocols, to accelerate the clinical translation of this promising therapy.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6167-6185"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484103/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S557248","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
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Abstract
Background: Glioblastoma (GBM) remains the most lethal primary brain tumor with a dismal prognosis despite standard therapies. Oncolytic viruses (OVs), which selectively destroy cancer cells and stimulate anti-tumor immunity, have emerged as a promising therapeutic strategy. This study aims to systematically map the global research landscape, knowledge structure, and evolutionary trends of OV therapy for gliomas.
Methods: Publications from 2009 to 2025 were retrieved from the Web of Science Core Collection (WOSCC). Bibliometric analysis and knowledge mapping were conducted using CiteSpace and RStudio to analyze collaboration networks, co-citation patterns, and keyword evolution.
Results: A total of 559 publications were analyzed. The annual output has grown exponentially since 2020, with the USA and China being the most productive countries. A clear paradigm shift was identified, moving from early research focused on direct oncolysis by viral vectors like Herpes Simplex Virus to a current emphasis on immuno-virotherapy. Recent hotspots are dominated by keywords such as immunotherapy, combination, tumor microenvironment, and T-cells, indicating a research trajectory towards complex, synergistic treatment strategies. Harvard University and Brigham and Women's Hospital are the leading institutions in this field.
Conclusion: The research field of oncolytic virotherapy for gliomas is rapidly advancing, with a clear evolution towards sophisticated combination immunotherapies. This analysis provides a comprehensive roadmap of the field's knowledge base and identifies key future directions, including overcoming delivery barriers and developing personalized treatment protocols, to accelerate the clinical translation of this promising therapy.
期刊介绍：
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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