Journal of Multidisciplinary Healthcare最新文献

{"title":"Multimodal Magnetic Resonance Imaging and Radiomics in Brucella Spondylitis: Diagnostic Applications and Differential Diagnosis.","authors":"Xiaopeng Wu, Ruijun Wang","doi":"10.2147/JMDH.S536880","DOIUrl":"10.2147/JMDH.S536880","url":null,"abstract":"<p><p>Brucella spondylitis (BS) is one of the most common and serious complications of brucellosis, with insidious clinical manifestations and lack of specificity, which often delay the disease and cause a series of adverse consequences such as multi-organ involvement and dysfunction in severe cases. Due to the lag of laboratory-related laboratory tests and pathological examinations and the many factors that interfere with the confirmed results, the diagnosis and treatment of BS are affected. Magnetic resonance imaging (MRI) is particularly important in the diagnosis of BS and in the assessment of disease progression, treatment efficacy, and prognosis through a refined response to the structure and function of diseased tissues due to its multiparametric imaging and good tissue resolution. Radiomics, as an emerging means to quantitatively analyze image information and provide disease diagnosis and treatment assistance, is gradually showing its important value, by screening the omics features of the imaging affected vertebral bodies, constructing a diagnostic model based on machine learning, and conducting research on the diagnosis and differential diagnosis of BS.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6091-6101"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Driven Development of the Chalerm App: A Mobile Health Application for Chronic Disease Management and Elderly Care in Southern Thailand.","authors":"Akkachai Lekapol, Buppha Raksanam, Wittaya Sornkaew, Phiman Thirarattanasunthon, Worayuth Nak-Ai, Abdulloh Bunmalert, Rattana Kraikaew, Benjawan Chuaykaew, Lafi Munira, Anwar Mallongi","doi":"10.2147/JMDH.S541792","DOIUrl":"10.2147/JMDH.S541792","url":null,"abstract":"<p><strong>Background: </strong>Mobile health (mHealth) applications have the potential to improve chronic disease management and healthcare support for older adults. However, their development and contextual adaptation in rural communities remain limited. This study aimed to develop and evaluate the Chalerm App, a mobile health application designed to strengthen chronic disease management, service accessibility, and caregiver support among older adults in Southern Thailand.</p><p><strong>Methods: </strong>A participatory action research (PAR) design was conducted at a Health Promoting Hospital in Nakhon Si Thammarat Province, Southern Thailand, from March to August 2024. The Chalerm App was developed on Android- and iOS-based platforms through collaboration with software developers, health professionals, and community stakeholders. The study comprised three phases. In Phase 1 (Situation analysis), 223 participants-including 30 elderly individuals, 10 health staff, 7 community leaders, and 176 community members-were recruited using stratified random sampling and participated in interviews and focus groups to identify care gaps. In Phase 2 (Mobile Health Application Development), 30 participants-including 10 health staff, 7 community leaders, and 13 elderly individuals with their caregivers-engaged in co-designing the app. In Phase 3 (Usability and Effectiveness Assessment), 30 elderly individuals and caregivers, recruited via simple random sampling, evaluated the app using a validated researcher-developed tool.</p><p><strong>Results: </strong>In Phase 1, the main challenges identified included the high prevalence of chronic diseases (hypertension, diabetes, and degenerative joint disease), psychological issues such as loneliness and depression, limited access to healthcare due to geographical and workforce constraints, and low levels of digital literacy. In Phase 2, the Chalerm App was developed with four key functions: (1) Remote Appointment Scheduling, (2) Demographic Information Display, (3) Home Navigation Support, and (4) Health Knowledge Repository. In Phase 3, the evaluation demonstrated that the app significantly exceeded the quality benchmark (p < 0.001), showing notable improvements in elderly healthcare performance, perceptions of the innovation, and the overall quality of care services (p < 0.001).</p><p><strong>Conclusion: </strong>The Chalerm App improved chronic disease management, service accessibility, and caregiver support for older adults in a rural Thai community. Findings suggest that community-driven mHealth solutions can reduce healthcare inequities in resource-limited settings with potential applicability to similar contexts.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6115-6125"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Nutritional Management on Postoperative Recovery Outcomes in Prostate Cancer Patients Undergoing Radical Prostatectomy: A Retrospective Study.","authors":"Guoyu Du, Yi Zhang","doi":"10.2147/JMDH.S549544","DOIUrl":"10.2147/JMDH.S549544","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer remains a prevalent malignant tumor among males globally, while the impact of perioperative nutritional management on prognosis remains poorly defined. This study aims to investigate the management efficacy of dietary supplement (nutrient) administration in prostate cancer patients following radical prostatectomy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 70 prostate cancer patients who underwent radical prostatectomy at our institution between March 2022 and January 2024. Participants were divided into two groups based on distinct perioperative management protocols: the control group received conventional management, while the observation group received targeted dietary supplements (nutrients) in addition to the conventional regimen. Comparative analyses were performed on clinical indicators, recovery parameters, and adverse symptom incidence between groups to evaluate the role of nutrient supplementation in perioperative management.</p><p><strong>Results: </strong>Baseline characteristics demonstrated comparability between groups (P>0.05). The observation group exhibited significantly shorter postoperative drainage tube removal duration and hospital stay compared to controls (P<0.05). First postoperative bowel movement time and independent ambulation recovery time were also reduced in the observation group (P<0.05). No statistically significant difference in BMI levels was observed between groups (P>0.05). Serum albumin levels measured at preoperative day 1, and postoperative days 1 and 3 were significantly elevated in the observation group (P<0.05). Postoperative day 3 serum immunoglobulin levels (IgG, IgA, IgM) showed marked increases in the observation group (P<0.05). The observation group reported significantly fewer gastrointestinal symptoms including thirst, hunger, and nausea compared to controls (P<0.05).</p><p><strong>Conclusion: </strong>Dietary supplement (nutrient) administration may improve perioperative nutritional parameters, enhance systemic immunity, facilitate postoperative rehabilitation, and alleviate gastrointestinal symptoms in prostate cancer patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6079-6090"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease.","authors":"Dong-Hong Huang, Yue-Ling Zhang, Sheng-Liang Shi, Tian-Jia Liang, Jun-Jian Chen, Guo-Qiao Li, Zhao-De Chen","doi":"10.2147/JMDH.S533723","DOIUrl":"10.2147/JMDH.S533723","url":null,"abstract":"<p><strong>Objective: </strong>Emerging evidence suggests a genetic link between immune-related diseases and Alzheimer's disease (AD), though the underlying mechanisms remain unclear. This Mendelian randomization (MR) study investigates the genetic relationship between six immune-related diseases-type 1 diabetes (T1DM), systemic lupus erythematosus (SLE), asthma, myasthenia gravis (MG), endometriosis, and idiopathic thrombocytopenic purpura (ITP)-and AD.</p><p><strong>Methods: </strong>Summary-level data were obtained from publicly available genome-wide association studies (GWAS) for the six immune-related diseases and AD. MR-estimation was conducted utilizing the inverse variance weighted (IVW), MR-Egger, and WM methods. Additionally, sensitivity analyses were performed, encompassing Cochran's Q test, MR-Egger intercept, MR-Pleiotropy residual sum and outlier (MR-PRESSO) method, leave-one-out analysis, and funnel plots.</p><p><strong>Results: </strong>A statistically significant association was identified between asthma and a slightly lower risk of AD (odds ratio [OR] = 0.996, 95% CI: 0.994-0.997, P = 0.001); however, the effect size was negligible and likely lacks clinical significance. No significant genetic associations were found between T1DM, SLE, MG, endometriosis, or ITP and AD. Reverse MR analyses indicated no evidence of reverse causality from AD to these immune-related conditions.</p><p><strong>Conclusion: </strong>Although a nominal association was observed, this MR analysis does not support a causal relationship between genetic liability to asthma and Alzheimer's disease. This relationship underscores the specificity of the association, as no causal connections were found between other studied immune-related diseases conditions-T1DM, SLE, MG, endometriosis, and ITP-and AD.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6063-6077"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses.","authors":"Ping Li, Tingting Qiu, Lvjie Xu, Liming Wu, Sixuan Zhao, Xiao Liu, Yiting Yang, Jiawei Wang","doi":"10.2147/JMDH.S539951","DOIUrl":"10.2147/JMDH.S539951","url":null,"abstract":"<p><strong>Purpose: </strong>To explore causal relationships between kidney function and the risk of senile cataract and primary open-angle glaucoma (POAG) using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Summary statistics for kidney function traits were obtained from the CKDGen consortium to identify genetically predicted chronic kidney disease (CKD), estimated glomerular filtration rate (eGFR), and urinary albumin-to-creatinine ratio (UACR). Data on senile cataract and POAG were sourced from the FinnGen consortium. Initially, we applied the bidirectional univariate MR method (UVMR) to assess the causal effects between kidney function and the risk of senile cataract and POAG. Inverse-variance weighted method (IVW) served as the primary analysis, supplemented by weighted median and MR-Egger methods. Subsequently, multivariable MR (MVMR) was conducted to validate significant causal associations identified in UVMR. Bioinformatics analyses were conducted through enrichment analysis and a protein-protein interaction network to elucidate potential molecular mechanisms.</p><p><strong>Results: </strong>UVMR showed that higher genetically predicted UACR was associated with an increased risk of senile cataract (IVW OR = 1.29, 95% CI: 1.05 to 1.58, P = 0.016), but no reverse causality was observed. No causal associations were found between CKD or eGFR and cataract, or between kidney function and POAG. MVMR further indicated that the associations of UACR with senile cataract remained robust after adjusting for potential confounders, including eGFR, telomere length, diabetes, hypertension, and smoking. Enrichment analysis highlighted significant associations with retinol metabolism, xenobiotic metabolism by cytochrome P450, and glycine/serine/threonine metabolism pathways.</p><p><strong>Conclusion: </strong>Our results suggested that kidney damage, as measured by UACR, causally increased the risk of cataract, but no causal relationship was found between kidney function and POAG. This study underscores the importance of regular ophthalmic screening for individuals with albuminuria.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6051-6061"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rise of Artificial Intelligence in Orthopedics: A Bibliometric and Visualization Analysis.","authors":"Shenghui Wu, Yu Miao, Jiong Mei, Shengren Xiong","doi":"10.2147/JMDH.S536633","DOIUrl":"10.2147/JMDH.S536633","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the progress and status of the application of artificial intelligence (AI) in orthopedics and highlight the current hot research areas.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed database, covering the period from 2010 to 2024. The R software (version 4.2.0) was used for the bibliometric analysis.</p><p><strong>Results: </strong>A total of 112 articles related to AI and orthopedics have been published, demonstrating a consistent upward trend in research output. Hot keywords, such as \"machine learning\", \"deep learning\", \"ChatGPT\", \"3D printing\", and \"arthroplasty\", were frequent occurring terms. While most countries engaged in extensive collaborative networks, the frequency of these partnerships remained relatively limited.</p><p><strong>Conclusion: </strong>The influence of AI in the field of orthopedics has been growing. This impact may signify the historic onset of the AI era in orthopedics, with milestones being set along the path from precision diagnostics to targeted treatments.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6037-6050"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics Associated with Length of Stay in Intensive Care Unit for Cancer Patients in China: A Nationwide Retrospective Cohort Study.","authors":"Guoxing Zhang, Haitao Liu, Rui Xia, Li Zhang, Kaizhong Liu, Dongmin Zhou, Xuezhong Xing, Haifeng Liu","doi":"10.2147/JMDH.S533848","DOIUrl":"10.2147/JMDH.S533848","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer patients can receive specialized care and monitoring at intensive care unit (ICU). However, prolonged ICU stay may increase medical expenses and risk of complications.</p><p><strong>Methods: </strong>To assess characteristics associated with length of stay (LOS) at ICU in Chinese cancer patients, a retrospective cohort study was conducted at 33 ICUs in China between May and July 2021. Cancer patients' demographics, medical history, disease severity, cancer types, status and treatments at the admission, death or survival, and LOS were documented. Characteristics associated with the LOS were determined by the bivariable and multivariable linear regression analyses.</p><p><strong>Results: </strong>The study included 1488 cancer patients, with a median age of 63 (interquartile range [IQR]: 56-72) years old, and 61.4% of patients were men. The median LOS was 4 (IQR, 2-7) days. Chronic renal failure, delirium, sepsis, renal replacement therapy, mechanical ventilation, sedatives, and feeding method were significantly associated with the LOS. Subgroup analysis indicated that chronic renal failure, delirium, sepsis, renal replacement therapy, mechanical ventilation, and feeding method (enteral with or without parenteral feeding) were associated with the LOS in patients who survived to be discharged from ICU. Only the feeding method was associated with the LOS in patients who died.</p><p><strong>Conclusion: </strong>A clinical history of chronic renal failure, along with specific conditions and treatments administered during admission, was significantly associated with the LOS at ICU for cancer patients overall.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6025-6035"},"PeriodicalIF":2.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial Analysis of Postoperative Recurrence of Anal Fistula: A Retrospective Study.","authors":"Fang Fang, Luping Wen","doi":"10.2147/JMDH.S537028","DOIUrl":"10.2147/JMDH.S537028","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to investigate the main factors that influence the recurrence of anal fistulas in patients with perianal abscesses following incision and drainage treatment.</p><p><strong>Methods: </strong>A retrospective case-control study was performed according to the STROBE guidelines for patients with perianal abscesses who underwent surgical treatment at Guangdong Provincial Hospital of Chinese Medicine in Zhuhai and at the Affiliated Hospital of Xuzhou Medical University in Lasso between June 2021 and June 2023. Lasso and multivariate logistic regression analyses were performed to further determine the recurrence of perianal abscesses.</p><p><strong>Results: </strong>A total of 435 patients were included in the study, with a median follow-up period of 25 months (range 18-40 months) after receiving treatment for perianal abscesses. Of these patients, 27 were in the anal fistula group and 408 were in the cured group. The results of the multivariate logistic regression analysis showed that a history of abscesses, enteritis, intraoperative pus cavity residue, standardized dressing changes after discharge, the surgeon's specialty, preoperative ultrasound or MRI examination, Parks classification and Wexner score were independently influential factors in the formation of anal fistulas after perianal abscess surgery (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>A history of abscesses and enteritis, Parks classification, and intraoperative pus cavity residue are high-risk factors for anal fistula recurrence. Standardized dressing changes after discharge, a preoperative ultrasound or MRI scan, and a postoperative assessment of anal function (Wexner score) are important for protecting anal sphincter function and improving the prognosis of perianal abscesses.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6015-6024"},"PeriodicalIF":2.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trends and Progress in Exercise Interventions for Depression: A Bibliometric Visualization Analysis.","authors":"Mingqi Wang, Shensen Lu, Lu Hao, Nan Chen, Yifei Xia","doi":"10.2147/JMDH.S529339","DOIUrl":"10.2147/JMDH.S529339","url":null,"abstract":"<p><strong>Objective: </strong>Depression is a chronic disorder that affects a considerable population worldwide. Exercise has been proposed as an effective adjunct for depression. Although there has been a significant amount of research on exercise for depression, there is a lack of reviews analyzing current state and frontier of the research. This study aims to identify current hot topics and tendencies in the field of exercise for depression.</p><p><strong>Methods: </strong>Articles and reviews on the topic of exercise for depression published in English between January 2010 and December 2023 were screened from the Web of Science Core Collection. The qualified records were evaluated quantitatively and visualized using CiteSpace software. The analysis contains information on authors, institutions, journals, publications, and countries/regions, as well as subject categories and keywords.</p><p><strong>Results: </strong>A total of 2405 records were analyzed. The number of related publications has been growing rapidly from 2010 to 2023. The Journal of Affective Disorders published the most articles (n = 137). The USA leads in terms of the number of publications (n = 684) and citations (n =19688). The most productive institution and author were King's College London (n = 69) and Stubbs B (n = 31), respectively. Psychiatry (n = 783) was definitely the first research hotspot category. The keywords analysis revealed that the group of interest was older adults, and the form of exercise of interest was Hatha yoga in the area.</p><p><strong>Conclusion: </strong>The topic of exercise for depression is an expanding field of research, with the expectation that it will remain a focus of investigation. The findings of our study indicate the key areas and potential avenues for further investigation in this field. More research is required to investigate potential mechanisms of exercise and to develop more personalized exercise prescriptions in order to effectively improve depression in specific populations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5961-5976"},"PeriodicalIF":2.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Barriers to Evidence Transformation and Countermeasures for MARSI Prevention in Tracheal Intubated Patients Based on the i-PARIHS Framework.","authors":"Minhua Hu, Jiajia Hu, Peng Sun, Hongyan Zheng, Mingyang Zhang","doi":"10.2147/JMDH.S531060","DOIUrl":"10.2147/JMDH.S531060","url":null,"abstract":"<p><strong>Objective: </strong>To systematically analyze the current status of evidence application for the prevention of medical adhesive-related skin injury (MARSI) in patients undergoing tracheal intubation, identify the multidimensional barriers and facilitators in the process of evidence translation on the basis of the i-PARIHS framework, and construct targeted intervention strategies.</p><p><strong>Methods: </strong>Review indicators were developed on the basis of the 30 pieces of best evidence for the prevention of medical adhesive-associated skin injury in patients with tracheal intubation obtained from a previous study, and the review results were analyzed for barriers and facilitators by applying the Evidence Application Barrier Identification Assessment Checklist under the i-PARIHS framework.</p><p><strong>Results: </strong>A total of 30 pieces of evidence were screened for conversion, and 24 review indicators were formulated, of which only 13 items (54.2%) had a compliance rate>60%, and 11 items (45.8%) had compliance rates<60%, with 3 key indicators (12.5%) having extremely low compliance rates (<10%). Key obstacles: Poor feasibility of change implementation: Evidence has not been transformed into easily accessible and actionable practical tools such as flowcharts and checklists; there is a lack of standardized operating procedures to guide clinical execution. Insufficient ability and cognition of change recipients, especially anesthesiologists: lack of relevant knowledge reserves; not receiving sufficient relevant training; lack of understanding and trust in the effectiveness of intervention measures. Organizational support and environmental deficiencies include a lack of effective incentive or constraint mechanisms such as performance linkages and quality feedback. The physical work environment, such as the operating space and equipment layout, has not been optimized to support new practices.</p><p><strong>Conclusion: </strong>The best evidence for preventing MARSI in endotracheal intubation patients shows significant differences in clinical translation, with nearly half of the reviewed indicators having insufficient compliance and serious missing items (<10%). It is urgent to develop and implement strengthened intervention strategies to address the multidimensional barriers mentioned above, particularly in terms of change enforceability, anesthesiologist capabilities, organizational mechanisms, and the environment; actively promoting healthcare personnel change; and facilitating the effective clinical translation of the best evidence.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5949-5959"},"PeriodicalIF":2.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}