Journal of Multidisciplinary Healthcare最新文献

{"title":"A Qualitative Study of Norwegian Care Institutions Health Care Workers' Experiences of Ad Hoc Ethical Reflection During the Workday.","authors":"Håkon Johansen, Ann Karin Helgesen, Ingrid Femdal","doi":"10.2147/JMDH.S534283","DOIUrl":"10.2147/JMDH.S534283","url":null,"abstract":"<p><strong>Background/objectives: </strong>The objective of the study was to explore experiences related to ad hoc ethical reflection and how ethical reflection might be structured. There has been limited research on the topic in the context of nursing homes and health care centres. Reflection is an ongoing practice in healthcare, often linked to problem-solving and clinical decision-making.</p><p><strong>Methods: </strong>The study has an exploratory design with a qualitative approach. The researchers conducted four group interviews. The data were analysed with systematic text condensation, which entails condensing meaning units following development of code groups.</p><p><strong>Results: </strong>When health care workers (registered nurses, auxiliary nurses, or care workers) encounter ethical uncertainty or ethical issues, they may perceive these situations as challenging. Occasionally, they take the initiative to conduct ad hoc ethical reflection, where they discuss different perspectives and make decisions collectively. Hence, ethical reflection contributes to collaboration. The structure of ad hoc ethical reflection appears to be shaped by two key components: problem-solving and consensus-building, while also addressing, to some extent, the values involved. Furthermore, ethical reflection often led to health care workers supporting each other.</p><p><strong>Conclusion: </strong>Ad hoc ethical reflection can improve decision-making and foster moral awareness among nursing home health care workers. Moreover, the study identifies a need to implement practices of ad hoc ethical reflection through training programs, such as simulation training. Future research, preferably observational, may provide deeper insight into the prerequisites, structure and performance of ad hoc ethical reflection, and how its conclusions are implemented.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6003-6014"},"PeriodicalIF":2.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Exosomes Associated with Rheumatic Diseases in the 21st Century.","authors":"Yuanyuan Zou, Shuwei Wang, Xingyue Ao, Jialu Zhang, Enhao Chen, Jinping Wang, Jing Luo, Qingwen Tao","doi":"10.2147/JMDH.S536183","DOIUrl":"10.2147/JMDH.S536183","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous studies have suggested that exosomes are associated with rheumatic diseases, but no bibliometric analysis has been performed. This study presents the first comprehensive bibliometric analysis aiming to evaluate the current research hotspots and to anticipate future trends.</p><p><strong>Methods: </strong>An electronic search was conducted in the Web of Science Core Collection (WOSCC) using exosome and rheumatic disease-specific terminology to identify eligible studies published from January 1, 2000 to October 19, 2024. Only English-language articles and review articles were selected for bibliometric analysis. Data analysis and visualization were conducted using CiteSpace 6.2.R3, VOSviewer 1.6.18, and the Bibliometrix R package.</p><p><strong>Results: </strong>A total of 1,251 publications with 49,374 citations were extracted from the WOSCC database. Both publication and citation frequency increased steadily. 255 different countries or regions, 4,413 institutions and 7,213 authors contributed to the field. China and the USA are the leading countries and Shanghai Jiao Tong University has a significant influence. Théry C is the most frequently co-cited researcher. Most papers are published in Frontiers in Immunology, while Stem Cell Research & Therapy has the highest citations. Research is primarily concentrated in cell biology, immunology, and experimental medicine. Exosm, mesenchymal stem cells (MSCs), autoimmunity, regeneration, and others are major areas of research in this field. Research hotspots primarily focus on the diagnostic potential and therapeutic applications of exosomes in osteoarthritis and rheumatoid arthritis. Exosomes derived from MSCs and their cargo, such as microRNAs (miRNAs), have the potential to serve as biomarkers and therapeutic vehicles in these diseases.</p><p><strong>Conclusion: </strong>This study firstly quantifies and identifies the current status and research frontiers of exosomes in RDs by using bibliometric analysis, which may provide valuable insights for researchers to navigate trends and emerging applications into the field.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5977-6001"},"PeriodicalIF":2.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective Commitment Influences Occupational Stressors Among Maternal and Child Health Nurses via Job Burnout as a Mediator.","authors":"Lixin Tian","doi":"10.2147/JMDH.S536236","DOIUrl":"10.2147/JMDH.S536236","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the mediating role of job burnout between affective commitment and occupational stressors among nurses working in maternal and child health settings, with the goal of informing strategies to enhance both physical and psychological well-being while supporting the quality and safety of nursing care.</p><p><strong>Methods: </strong>Maternal and child health nurses were recruited from a tertiary care hospital in Tongzhou District, Beijing between July and August 2024. Correlations among affective commitment, job burnout, and occupational stressors were assessed. The mediating role of job burnout was evaluated using structural equation modeling, and a model was constructed to verify the hypothesized affective commitment-job burnout-occupational stressors pathway.</p><p><strong>Results: </strong>The average item scores were 3.84 ± 1.48 for job burnout, 1.99 ± 0.75 for occupational stressors, and 3.60 ± 1.09 for affective commitment. Pearson's correlation coefficients indicated that affective commitment was negatively associated with both job burnout and occupational stressors, while job burnout was positively associated with occupational stressors. Structural equation modeling revealed that job burnout significantly mediated the relationship between affective commitment and occupational stressors, with an indirect effect value of -0.344, accounting for 35.16% of the total effect.</p><p><strong>Conclusion: </strong>Moderate levels of affective commitment, job burnout, and occupational stressors were observed among maternal and child health nurses. Job burnout played a mediating role between affective commitment and occupational stressors. Interventions aimed at enhancing organizational climate and mitigating job burnout may contribute to reduced occupational stress in this population.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5905-5916"},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing a Management Evaluation Index System Based on Hierarchical Analysis in the Interventional Therapy of Hematological Surgery in Hospitals.","authors":"Lingxue Fu, Yiying Wang, Zimian Gao, Weiwei Zhao, Miaomiao Wang, Huiqian Yu","doi":"10.2147/JMDH.S541171","DOIUrl":"10.2147/JMDH.S541171","url":null,"abstract":"<p><strong>Purpose: </strong>To construct a set of comprehensive, practical, scientific and reasonable management evaluation index system to provide strong theoretical support and practical guidance for improving the management level of interventional therapy of hematology surgery in hospitals.</p><p><strong>Methods: </strong>A research team was set up at an early stage and a large amount of literature was consulted to construct a preliminary evaluation index system for the management of interventional therapy in the Department of Hematologic Surgery, which was modified and improved with two rounds of Delphi expert correspondence; at the same time, the weighting of the index system was analyzed by using the hierarchical analysis method. The reliability of the questionnaire was evaluated by using the Cronbach's alpha coefficient, a measure of correlation and internal consistency, on 100 patients receiving interventional therapy.</p><p><strong>Results: </strong>The final evaluation index system of interventional therapy management in hematologic surgery includes 5 first-level indexes, 18 second-level indexes, and 41 third-level indexes; the Cronbach's α of all the first-level indexes is >0.7.</p><p><strong>Conclusion: </strong>The scientific, reliable, and practicality of the index system of interventional therapy management in hematologic surgery is high, and it provides a relevant basis for the continuous improvement of interventional therapy in hematologic surgery in the future. It provides a relevant basis for the continuous improvement of hematology surgery interventional therapy in the future.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5935-5947"},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualising the Knowledge Structure of Microglia in Alzheimer's Disease: A CiteSpace Analysis.","authors":"Qi Wang, Xiuchu Zhang, Delong Wang, Xinyu Jiang, Yanyan Zhou, Te Zhang, Xueying Yang, Li Liu, Quan Li","doi":"10.2147/JMDH.S521350","DOIUrl":"10.2147/JMDH.S521350","url":null,"abstract":"<p><strong>Purpose: </strong>Alzheimer's disease (AD) is a growing global health burden, yet effective therapies remain elusive. Microglia-the brain's resident immune cells-have emerged as key players in AD, capable of both neuroprotection and neurotoxicity. To elucidate research progress and gaps, we conducted a bibliometric analysis of global studies on \"microglia and AD\" from 2010 to 2025, highlighting advances beyond prior reviews.</p><p><strong>Methods: </strong>We searched the Web of Science Core Collection for relevant publications (2010-2025). After screening and deduplication, 12,275 records were analysed with CiteSpace 6.2.R4 to generate co-citation networks, keyword clusters, citation-burst timelines, and collaboration maps at national, institutional, and author levels.</p><p><strong>Results: </strong>Annual output rose markedly, peaking in 2022. The United States and China led the field; Harvard University, the University of California System, and the Chinese Academy of Sciences were the most prolific institutions. Influential authors included Holtzman, Heneka, Zetterberg, and Colonna. Co-citation analysis revealed three dominant knowledge clusters: microglial activation, TREM2-mediated immune responses, and neuroinflammation. Keyword evolution showed growing attention to TREM2 variants, NLRP3 inflammasome, single-cell omics, and novel imaging techniques, reflecting a shift toward microglial heterogeneity and translational research.</p><p><strong>Conclusion: </strong>Microglia occupy a central position in AD pathogenesis through intertwined molecular pathways and dynamic functional states. Future work should refine subtype-specific roles, integrate peripheral-central immune interactions, and accelerate the translation of mechanistic insights into targeted interventions. This bibliometric overview maps collaboration patterns and emerging themes, providing a strategic guide for researchers aiming to advance microglia-focused AD therapeutics.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5917-5933"},"PeriodicalIF":2.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital-at-Home in Taiwan: Reducing Hospital Stay and Medical Expenditures.","authors":"Tian-Hoe Tan, Yu-Chieh Ho, Hung-Lin Hsu, Ting-Chia Chang, Kang-Ting Tsai, Hung-Jen Tang, Chien-Chin Hsu, Hung-Jung Lin, Hsiu-Chin Chen, Chien-Cheng Huang","doi":"10.2147/JMDH.S547734","DOIUrl":"10.2147/JMDH.S547734","url":null,"abstract":"<p><strong>Background: </strong>Hospital-at-Home (HaH) is an alternative care model that delivers hospital-level treatment at home, improving patient outcomes while reducing healthcare costs. Despite its success globally, HaH was not implemented in Taiwan until the initiation of a pilot program. This study evaluates the outcomes of HaH compared to traditional hospitalization.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a tertiary medical center in Taiwan. HaH patients diagnosed with pneumonia, urinary tract infection, or soft tissue infection between August 1, 2024, and January 31, 2025, were included (n = 69). A matched hospitalized cohort (n = 246) was selected based on age, sex, and diagnosis. Outcomes, including length of stay, medical expenditure, emergency department (ED) visits, rehospitalization, and patient satisfaction, were analyzed using univariate and logistic regression analyses.</p><p><strong>Results: </strong>The HaH cohort had a significantly shorter length of stay (adjusted OR: 0.53, 95% CI: 0.30-0.93, p = 0.028) and lower medical expenditure (adjusted OR: 0.18, 95% CI: 0.10-0.33, p < 0.001). HaH patients were more likely to transition to home healthcare (73.9% vs 7.3%, p < 0.001), and satisfaction was 100%. No significant differences were found in ED visits or rehospitalization rates between the two cohorts (all p > 0.05).</p><p><strong>Conclusion: </strong>HaH is an effective alternative to hospitalization, reducing length of stay and medical expenses while maintaining patient safety and satisfaction. Expanding HaH to additional conditions could further enhance healthcare efficiency. These findings highlight HaH's feasibility in Taiwan and its role in healthcare resilience.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5893-5903"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Research for Inherited Retinal Disease Related Pediatric Blindness: A Preliminary Descriptive Analysis Based on ClinicalTrials.gov.","authors":"Ahmed M Ashour, Maan H Harbi, Fahad S Alshehri, Saad M Wali, Mohammed M Aldurdunji, Nasser M Alorfi","doi":"10.2147/JMDH.S539699","DOIUrl":"10.2147/JMDH.S539699","url":null,"abstract":"<p><strong>Background: </strong>Childhood blindness is a significant global health concern, consistently identified in existing research as stemming from rare genetic and congenital disorders. With the technological advances of the 21^st century which have positively impacted many areas of human life, healthcare included, recent advances in gene therapy and pharmacological interventions have served to spur clinical research in this area. The primary focus of the current study was to use data from ClinicalTrials.gov to carry out a preliminary exploration and and descriptive analysis of clinical trials focusing on the treatment of childhood blindness.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using data from ClinicalTrials.gov. The initial search for data in ClinicalTrials.gov yielded a total of 110 studies under blindness-related conditions. Upon further cross-examination of these studies based on the inclusion criteria, only five interventional trials (published between 2012 and 2023) specifically targeting childhood blindness met the inclusion criteria and were therefore included. Key trial characteristics studied conditions, intervention types, outcome measures, study phases, and enrollment sizes were extracted and analyzed descriptively.</p><p><strong>Results: </strong>Across the five included trials, a majority of trials investigated rare genetic conditions, including Leber Congenital Amaurosis, Wolfram Syndrome, and Osteoporosis Pseudoglioma. On interventions, the most commonly used approaches for handling childhood blindness include gene therapy vectors like AAV RPE65, antisense oligonucleotides like QR-110, and repurposed pharmacological agents such as lithium and dantrolene sodium. All studies included children within their target populations, and most were early-phase (Phase 1/2) trials with small sample sizes (11-26 participants). Primary outcomes focused on safety, while secondary outcomes assessed visual function and biochemical changes.</p><p><strong>Conclusion: </strong>Although limited in number, current clinical trials represent a promising shift toward targeted therapies for childhood blindness. The dominance of early-phase studies highlights the need for expanded, multicenter, and later-phase trials. Future research should aim to improve trial accessibility, standardize outcome measures, and ensure ethical conduct in pediatric populations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5865-5874"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Traditional Chinese Medicine into Maternity Care: Development and Evaluation of a Delphi-Based Training Course to Enhance Nurses' Competency - A Quasi-Experimental Study.","authors":"Shijie Huang, Zhaoying Chen, Shiying Cai, Ling Chen, Wei Ren, Wenzhi Cai","doi":"10.2147/JMDH.S517695","DOIUrl":"10.2147/JMDH.S517695","url":null,"abstract":"<p><strong>Purpose: </strong>Traditional Chinese medicine(TCM) has significant advantages in regulating the maternal constitution and promoting the healthy development of the fetus with its unique concept of health and fetal protection. However, there is no systematic training course for maternity nurses. Therefore, this study focused on designing a training course for maternity nurses on TCM health preservation during pregnancy and the perinatal period.</p><p><strong>Methods: </strong>A two-round Delphi process with 18 multidisciplinary experts (clinicians, educators, TCM specialists) was employed to establish consensus on the training course through anonymous iterative feedback. From August 2024 to October 2024, a quasi-experimental design was utilized to conveniently recruit 84 maternity nurses from two hospitals for comparison. Among them, 42 nurses in the observation group received the training curriculum validated through the Delphi method, while 42 nurses in the control group received conventional education. The TCM knowledge, behavioral competence, and clinical competency of nurses in both groups were assessed using a standardized questionnaire before and after the training, to compare the intervention effects.</p><p><strong>Results: </strong>The recovery rates of the two rounds of consultation were 100% and 88.8%, and the authority coefficients of experts were 0.771 and 0.822, respectively. The TCM health preservation during pregnancy and perinatal period training course for maternity nurses was formed, including 4 first-level indicators, 15 second-level indicators and 77 third-level indicators. The results of empirical research showed that the scores of knowledge, behavior ability and competency level of nurses in the observation group were significantly higher than those in the control group (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The TCM health preservation during pregnancy and perinatal period training course for maternity nurses is scientific and reliable, which can provide a reference for maternity nurses to learn the knowledge and technology of TCM.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5837-5847"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Nephropathy Screening as a Health Seeking Behavior Among Type 2 Diabetes Mellitus Patients: A Phenomenological Study in Southwestern Uganda.","authors":"Ritah Kiconco, Robert Kalyesubula, Naomi Sanyu, Bosco Bekiita Agaba, Erick Nyakundi Ondari, Deusdedit Tusubira, Gertrude N Kiwanuka","doi":"10.2147/JMDH.S551738","DOIUrl":"10.2147/JMDH.S551738","url":null,"abstract":"<p><strong>Background: </strong>Nephropathy screening is vital in type 2 diabetes mellitus (T2DM) management to prevent complications, yet uptake remains low in resource-limited settings like Southwestern Uganda. This study explored the barriers and facilitators influencing screening among T2DM patients and providers at the diabetic clinic of Mbarara Regional Referral Hospital.</p><p><strong>Methods: </strong>A qualitative cross-sectional study guided by a phenomenological approach to explore lived experiences around nephropathy screening was conducted. Fifteen adult T2DM patients in care for ≥12 months and five healthcare providers (doctors, nurses, and a laboratory technician) were purposively sampled. Semi-structured, in-depth interviews were conducted. Data were analyzed using an inductive approach. Socio-demographics; including age, sex, education, and employment were collected. All interviews were audio-recorded, transcribed verbatim, and thematically analyzed using Dedoose (version 10.0.25). Study reporting adhered to the COREQ 32-item checklist.</p><p><strong>Results: </strong>Patients described diabetes as a burdensome and life-altering condition. Key barriers to nephropathy screening included financial constraints, lack of transport, limited awareness, and dissatisfaction with care. Despite these challenges, facilitators such as proactive provider encouragement, community outreach, and availability of free testing motivated screening uptake. Providers emphasized their critical role in educating patients and detecting nephropathy but reported systemic constraints, including staff shortages, equipment failures, limited knowledge on new disease trends and screening protocols. Both groups highlighted the need for routine integration of nephropathy screening into diabetes care and greater support from the health system.</p><p><strong>Conclusion: </strong>Nephropathy screening behaviors among T2DM patients are influenced by perceived disease severity, provider communication, and systemic barriers such as cost and infrastructure. While both patients and providers recognize the value of early detection, sustained screening is hindered by resource limitations and inconsistent implementation. Strengthening institutional capacity, integrating screening into routine care, and enhancing patient-provider engagement are essential to reducing the burden of diabetic nephropathy in the study setting.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5875-5892"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Research Landscape of Polyphenols in Osteoarthritis: A Bibliometric Perspective.","authors":"Weibei Sheng, Siyang Cao, Haotian Qin, Peng Liu, Deli Wang, Hui Zeng, Jian Weng, Fei Yu","doi":"10.2147/JMDH.S547995","DOIUrl":"10.2147/JMDH.S547995","url":null,"abstract":"<p><p>Polyphenols, a diverse group of plant-derived compounds known for their antioxidant and anti-inflammatory properties, have garnered increasing attention for their therapeutic potential in osteoarthritis (OA). However, a comprehensive bibliometric analysis of the research landscape in this field has been lacking. This study aimed to systematically evaluate global research trends, knowledge structure, and emerging hotspots related to polyphenols in OA. Publications from 2000 to 2025 were retrieved from the Web of Science Core Collection and analyzed using bibliometric tools such as VOSviewer and CiteSpace. A total of 1,436 publications were identified, demonstrating a steady rise in annual output, with China and the United States emerging as the most prolific contributors. Keyword co-occurrence and citation burst analyses revealed that curcumin, resveratrol, EGCG, inflammation, oxidative stress, and cartilage degeneration are central research themes. Notably, recent trends highlight increasing interest in ferroptosis, gut microbiota, and targeted drug delivery systems in the context of polyphenol-based OA therapies. This bibliometric analysis provides a comprehensive overview of the current status and developmental trajectory of polyphenol research in OA, offering valuable insights to guide future studies and foster interdisciplinary collaboration.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"5849-5864"},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}