Journal of Multidisciplinary Healthcare最新文献

{"title":"Exploring Early Mobilization Practices in Adult Intensive Care Units in Jordan: A Cross-Sectional Survey.","authors":"Adnan Wshah, Sakher Obaidat, Amjad I Shallan, Ahmad Muhsen, Bodor Bin Sheeha, Asmaa Alkasassbeh, Shadi Wshah, Abdel Razzaq Bassam Al Hadidi, Thamer A Altaim, Batul Sawafta, Salsabeel Alqallab","doi":"10.2147/JMDH.S524236","DOIUrl":"10.2147/JMDH.S524236","url":null,"abstract":"<p><strong>Background: </strong>Prolonged immobilization in critically ill patients in the intensive care unit (ICU) is associated with adverse health outcomes, such as ICU-acquired weakness (ICU-AW), pressure ulcers, and decreased cardiopulmonary function. Early mobilization has been shown to be an important intervention to mitigate these effects; however, there is limited information regarding its implementation in ICUs in Jordan. This study aimed to explore early mobilization practices in adult ICUs in Jordan and identify common strategies employed by healthcare professionals.</p><p><strong>Methods: </strong>An observational, cross-sectional survey was conducted among healthcare professionals working in various ICUs across Jordan. A structured online questionnaire collected data on participants' demographics, patient selection criteria for early mobilization, and early mobilization practices. Descriptive and inferential statistics (Kruskal‒Wallis, Mann‒Whitney, Chi‒square, and Fisher's exact tests) were used, with significance at p < 0.05.</p><p><strong>Results: </strong>A total of 200 surveys were completed, primarily from physiotherapists (34.5%) and nurses (21%). The most common early mobilization strategies reported were positioning (19.3%), active mobilization (14.4%), and passive mobilization (13.1%). The majority of respondents combined early mobilization with secretion drainage activities. Respiratory stability was the most frequently cited criterion for determining patient eligibility. A significant proportion of respondents (36%) reported the absence of standardized protocols for early mobilization in their ICUs.</p><p><strong>Conclusion: </strong>Early mobilization is recognized among healthcare professionals in Jordan as an essential practice in ICUs, but there are variations in its implementation and a lack of standardized protocols. These findings highlight the need for clear guidelines and training initiatives to support consistent practice. Future research should investigate barriers to early mobilization, particularly in high-risk populations, to improve outcomes in critically ill patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3749-3761"},"PeriodicalIF":2.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate Change and Health.","authors":"Scott Fraser","doi":"10.2147/JMDH.S544176","DOIUrl":"10.2147/JMDH.S544176","url":null,"abstract":"","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3763-3764"},"PeriodicalIF":2.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Anemia Among Patients with Chronic Kidney Disease: A Systematic Review of Empirical Evidence.","authors":"Prapatsinee Prapaiwong, Suebsarn Ruksakulpiwat, Pawitra Jariyasakulwong, Piyoros Kasetkala, Wimolrat Puwarawuttipanit, Kewalin Pongsuwun","doi":"10.2147/JMDH.S535423","DOIUrl":"10.2147/JMDH.S535423","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to identify and synthesize empirical evidence regarding determinants of anemia among patients with chronic kidney disease (CKD) to inform clinical management and guide future research.</p><p><strong>Methods: </strong>A comprehensive search of six electronic databases (PubMed, MEDLINE, ScienceDirect, Scopus, Web of Science, Google Scholar) was conducted for studies published from 2019 to 2024, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklists tailored to each study design, and data synthesis was performed using convergent thematic analysis.</p><p><strong>Results: </strong>Of 2269 records initially identified, 21 studies met inclusion criteria. Most studies originated from China (33.3%), employed cross-sectional designs (66.6%), and were hospital-based. Overall methodological quality was moderate to high, with JBI scores ranging from 69.23% to 100% (mean = 86.48%); notably, 47.6% of studies achieved a perfect quality score. Seven key themes emerged: 1) demographic and personal characteristics, 2) comorbidities, 3) duration of dialysis treatment, 4) kidney function, 5) biomarkers and metabolic ions, 6) geographic disparities, and 7) stimulation interventions (including stimulating agents, supplements, and exercise). Our review highlights that comorbidity (eg, diabetes mellitus, low BMI), declining kidney function, prolonged dialysis duration, and biomarkers such as calcium, phosphorus, ferritin, and inflammatory markers were significantly associated with anemia. Geographic disparities highlighted greater anemia prevalence in rural populations.</p><p><strong>Conclusion: </strong>This review underscores multifaceted determinants of anemia in CKD, emphasizing comprehensive assessment and targeted interventions. Future research should explore individualized strategies addressing these diverse factors.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3765-3780"},"PeriodicalIF":2.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Caffeine Intake and Bowel Habits and Inflammatory Bowel Disease: A Population-Based Study.","authors":"Xiaoxian Yang, Haiyi Yan, Yan Chen, Rui Guo","doi":"10.2147/JMDH.S512855","DOIUrl":"10.2147/JMDH.S512855","url":null,"abstract":"<p><strong>Background: </strong>The effect of caffeine in coffee, a popular beverage, on gastrointestinal symptoms has been the subject of ongoing debate worldwide. The present study explored the association between caffeine intake and bowel habits and Inflammatory bowel disease (IBD).</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2010 were utilized for this cross-sectional survey. Bowel habits and IBD were defined by self-report. Logistic regression models assessed the linear relationship between caffeine intake and chronic constipation. Nonlinear associations were delineated using fitted smoothed curves and threshold effect analyses. Finally, subgroup analyses and interactions were used to test the stability of the findings.</p><p><strong>Results: </strong>This population-based study included a total of 12,759 adults. We found that caffeine intake was negatively associated with chronic diarrhea. There was a U-shaped nonlinear relationship between caffeine intake and chronic constipation. To the left of breakpoint 2.04 (100 mg/1 unit), caffeine intake was negatively associated with chronic constipation (OR [95% CI]: 0.82 [0.74, 0.90]), however, to the right of the breakpoint, there was a positive association (OR [95% CI]: 1.06 [1.00, 1.12]). In addition, no significant association was found between caffeine intake and IBD. Subgroup analyses and interaction tests showed that caffeine intake was simply negatively associated with chronic constipation in older adults.</p><p><strong>Conclusion: </strong>In conclusion, moderate caffeine intake may help with bowel movements, but excessive caffeine intake may cause chronic constipation. Appropriate caffeine intake in older adults may help prevent chronic constipation. This suggests that in our clinical practice, we need to strategize caffeine intake according to the population's defecation status.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3717-3726"},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auxiliary Diagnosis of Pulmonary Nodules' Benignancy and Malignancy Based on Machine Learning: A Retrospective Study.","authors":"Wanling Wang, Bingqing Yang, Huan Wu, Hebin Che, Yue Tong, Bozun Zhang, Hongwu Liu, Yuanyuan Chen","doi":"10.2147/JMDH.S518166","DOIUrl":"10.2147/JMDH.S518166","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer, one of the most lethal malignancies globally, often presents insidiously as pulmonary nodules. Its nonspecific clinical presentation and heterogeneous imaging characteristics hinder accurate differentiation between benign and malignant lesions, while biopsy's invasiveness and procedural constraints underscore the critical need for non-invasive early diagnostic approaches.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed outpatient and inpatient records from the First Medical Center of Chinese PLA General Hospital between 2011 and 2021, focusing on pulmonary nodules measuring 5-30mm on CT scans without overt signs of malignancy. Pathological examination served as the reference standard. Comparative experiments evaluated SVM, RF, XGBoost, FNN, and Atten_FNN using five-fold cross-validation to assess AUC, sensitivity, and specificity. The dataset was split 70%/30%, and stratified five-fold cross-validation was applied to the training set. The optimal model was interpreted with SHAP to identify the most influential predictive features.</p><p><strong>Results: </strong>This study enrolled 3355 patients, including 1156 with benign and 2199 with malignant pulmonary nodules. The Atten_FNN model demonstrated superior performance in five-fold cross-validation, achieving an AUC of 0.82, accuracy of 0.75, sensitivity of 0.77, and F1 score of 0.80. SHAP analysis revealed key predictive factors: demographic variables (age, sex, BMI), CT-derived features (maximum nodule diameter, morphology, density, calcification, ground-glass opacity), and laboratory biomarkers (neuroendocrine markers, carcinoembryonic antigen).</p><p><strong>Conclusion: </strong>This study integrates electronic medical records and pathology data to predict pulmonary nodule malignancy using machine/deep learning models. SHAP-based interpretability analysis uncovered key clinical determinants. Acknowledging limitations in cross-center generalizability, we propose the development of a multimodal diagnostic systems that combines CT imaging and radiomics, to be validated in multi-center prospective cohorts to facilitate clinical translation. This framework establishes a novel paradigm for early precision diagnosis of lung cancer.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3735-3748"},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Diagnostic Utility of Combining Electromyography with Clinical and Pathological Indices in the Diagnosis of Diabetic Peripheral Neuropathy: A Retrospective Study.","authors":"Wenhua Wang, Ziwei Gong, Siyi Wang, Gang Li","doi":"10.2147/JMDH.S525731","DOIUrl":"10.2147/JMDH.S525731","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic value of combining electromyography (EMG) with clinical and pathological parameters in diagnosing diabetic peripheral neuropathy (DPN).</p><p><strong>Methods: </strong>A retrospective study was conducted on 156 diabetic patients (69 with DPN, 87 without) treated from July 2022 to December 2024. Clinical, biochemical, and EMG parameters were compared between groups. Multivariate logistic regression identified independent predictors of DPN. ROC curve analysis assessed diagnostic performance.</p><p><strong>Results: </strong>Group A (DPN) had significantly higher levels of glycated hemoglobin, cystatin C, uric acid, and creatinine, and significantly reduced motor and sensory nerve conduction velocities compared to Group B. Logistic regression identified these indicators as independent risk factors. Combined ROC analysis showed higher diagnostic accuracy (AUC = 0.873) than any single indicator.</p><p><strong>Conclusion: </strong>The combination of EMG with selected clinical and pathological parameters offers high diagnostic accuracy for DPN in diabetic patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3727-3734"},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Efficacy of Combined N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) and Cardiac Troponin I (cTnI) Testing in Myocardial Injury of Children with <i>Mycoplasma</i> Pneumoniae Pneumonia.","authors":"Mei Yang, Aili Xuan, Guoji Zhu","doi":"10.2147/JMDH.S527700","DOIUrl":"10.2147/JMDH.S527700","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic performance of combined N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) testing for myocardial injury in children with Mycoplasma pneumoniae pneumonia (MPP).</p><p><strong>Methods: </strong>This retrospective study included 103 pediatric patients with MPP complicated by myocardial injury admitted between December 2021 and December 2023. Patients were stratified by New York Heart Association (NYHA) functional class (I-IV). Demographic and clinical characteristics, biomarker levels, and diagnostic accuracy were analyzed. ROC curves were used to assess diagnostic performance of single and combined biomarkers.</p><p><strong>Results: </strong>No significant differences were observed in age or gender across NYHA classes. However, BMI Z-scores declined significantly with worsening class (P = 0.013), while heart rate, systolic blood pressure, fever duration, respiratory rate, and hospital stay increased progressively (all P < 0.01), indicating disease severity. Serum NT-proBNP and cTnI levels rose in parallel with advancing NYHA class (P < 0.001 between all adjacent groups). A strong positive correlation was found between NT-proBNP and cTnI (r = 0.617, P < 0.001). Combined biomarker testing demonstrated superior diagnostic accuracy (AUC = 0.914), outperforming NT-proBNP (AUC = 0.877) and cTnI alone (AUC = 0.739). The combination improved sensitivity (94.15%) and specificity (95.19%), reducing false negatives and enhancing risk stratification. Notably, 80% of NYHA class III-IV cases were correctly reclassified into the high-risk group, with a net reclassification improvement (NRI) of +34.2% (P = 0.002).</p><p><strong>Conclusion: </strong>Combined NT-proBNP and cTnI testing provides robust diagnostic efficacy for myocardial injury in pediatric MPP. This dual-biomarker strategy enables earlier identification of high-risk patients and supports more precise clinical management.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3709-3716"},"PeriodicalIF":2.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Communication in Managing Chronic Lower Limb Wounds.","authors":"Davide Costa, Raffaele Serra","doi":"10.2147/JMDH.S533416","DOIUrl":"10.2147/JMDH.S533416","url":null,"abstract":"<p><p>Chronic wounds of the lower limbs present a significant global healthcare challenge, requiring interdisciplinary management and patient adherence to treatment protocols. Effective communication plays a pivotal role in ensuring optimal outcomes, fostering patient engagement, and promoting interdisciplinary collaboration. This review article explores the role of communication in managing chronic wounds of the lower limbs, highlighting its impact on patient education, adherence, early detection, emotional support, and healthcare coordination. It synthesizes the most updated literature on the subject, identifying best practices and potential areas for improvement. The review also examines technological advancements in communication, such as telemedicine and mobile health applications, that facilitate wound care management. Additionally, challenges and potential solutions related to communication barriers are discussed. This comprehensive analysis provides insights into communication strategies that can be implemented globally to enhance wound care outcomes. Further, it explores the role of culture, socioeconomic factors, and health literacy in shaping effective communication strategies. Finally, ethical and policy implications are addressed, offering a holistic understanding of the broader impact of communication on chronic wound management. Effective communication is not only essential in clinical settings but also within public health frameworks, influencing health literacy campaigns, wound prevention strategies, and patient advocacy efforts. The integration of culturally competent communication practices, consideration of social determinants of health, and the use of artificial intelligence in patient-provider interactions further shape the effectiveness of communication in chronic wound care. This review provides a foundation for future research on how evolving communication methodologies can further enhance patient outcomes and reduce disparities in wound care management worldwide.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3685-3708"},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Practice Respiratory Therapy in the State of California: A Cross-Sectional Needs Assessment Study.","authors":"Abdullah Alismail, Yiqing Xu, Krystal Craddock, David Lopez, Michael Terry, Laren Tan","doi":"10.2147/JMDH.S530602","DOIUrl":"10.2147/JMDH.S530602","url":null,"abstract":"<p><strong>Introduction: </strong>As the respiratory therapy (RT) profession in the United States discusses the establishment of the Advanced Practice in Respiratory Therapy (APRT) profession, the purpose of this study was to investigate the perception of the respiratory therapy community in the state of California (CA) on the need to start the APRT profession within the state.</p><p><strong>Methods: </strong>This was a descriptive pilot cross-sectional anonymous study that was approved by the institutional review board at Loma Linda University. Survey was sent via Email to program directors, faculty, students, bedside RTs, and hospital managers/directors by The Respiratory Care Board of CA, and the California Society in Respiratory Care to be sent out to their constituents.</p><p><strong>Results: </strong>A total of 1030 responded to the survey. Of the respondents, 50.6% were males and 48.1% females, with mean age of 45.7 ± 13.1 years. Most were practicing RTs (74.2%). Majority of the respondents held at least a bachelor's degree and worked in a mid-size hospital. An overwhelming majority of the respondents supported the establishment of APRT in CA (91.9%). When asked about APRT educational level, 56% recommended a graduate degree. Nearly 56% of the respondents had knowledge of APRT prior to the survey, with 68.1% of them showing interest in applying for an APRT program once established. The main identified barriers to implementation were acceptance among other advanced practice providers, acceptance among physicians, legislation, scope of practice, and reimbursement. A majority believed that APRT should require a separate license, 71.7%. Chi-Square results showed that those with higher education were more supportive of APRT than those with high school, p = 0.015.</p><p><strong>Conclusion: </strong>The results of this pilot study show the strong support of the respiratory therapy workforce in California for establishing APRT. In addition, respondents believed that APRT should have its own separate license and those holding higher education were more supportive to establish APRT within the state. Further research is needed by surveying physicians, nurse practitioners, and physician assistants on the need for APRT within the state.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3673-3684"},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Brain's Role in Osteoarthritis: New Evidence for Prevention.","authors":"Jingkai Di, Yujia Xi, Yaru Liu, Likun Qi, Shuai Chen, Yingda Qin, Chuan Xiang","doi":"10.2147/JMDH.S522952","DOIUrl":"10.2147/JMDH.S522952","url":null,"abstract":"<p><strong>Purpose: </strong>This study explores the causal link between brain structural parameters and Osteoarthritis (OA), aiming to prevent OA progression.</p><p><strong>Patients and methods: </strong>We used two-sample Mendelian randomization. In addition to European OA data with a sample size of 484,598, Firth correction OA data from the same source, and SPA correction OA data were included as outcome data. 3913 brain imaging-derived phenotypes (IDPs) from the UK Biobank were used as exposure data. Weighted median, MR Egger, and IVW validated causal correlations. Analyses of sensitivity and heterogeneity validated the robustness of the findings.</p><p><strong>Results: </strong>Thirteen brain regions significantly linked to OA. Increased fractional anisotropy (FA) in the cingulate hippocampal gyrus (OR: 0.99, 95% CI: 0.98-1.00, P = 0.003), orientation diffusion(OD) in the fornix and Stria terminalis (OR: 0.99, 95% CI: 0.98-1.00, P = 0.004) and isotropic volume fraction (ISOVF) (OR: 0.99, 95% CI: 0.99-1.00, P = 0.039) in the fornix, as well as an increase in OD in the posterior thalamic radiation (R) (OR: 0.99, 95% CI: 0.98-1.00, P = 0.047) reduce OA risk as protective factors. Increased subparietal lobule area (OR: 0.99, 95% CI: 0.98-1.00, P = 0.045) and middle temporal gyrus volume (OR: 0.98, 95% CI: 0.97-1.00, P = 0.029) also demonstrated a protective effect against OA. Conversely, OA risk was increased by increases in the medial thalamic tract's OD (OR: 1.01, 95% CI: 1.00-1.02, P = 0.034), the cerebral peduncle's intracellular volume fraction (ICVF) (OR: 1.01, 95% CI: 1.00-1.01, P = 0.010), the anterior limb of the internal capsule's ISOVF (OR: 1.01, 95% CI: 1.00-1.01, P = 0.033), and the posterior thalamic radiation(L) 's MO (OR: 1.02, 95% CI: 1.00-1.03, P = 0.024). Interestingly, lateral orbitofrontal volume decreased (R: OR: 0.99, 95% CI: 0.98-1.00, P = 0.013; L: OR: 0.99, 95% CI: 0.98-1.00, P = 0.038), while medial orbitofrontal increased risk (OR: 1.02, 95% CI: 1.00-1.04, P = 0.024).</p><p><strong>Conclusion: </strong>Our findings provide genetic evidence for the prevention of OA based on the bone-brain axis and suggest a clinical strategy for integrated pain-psychomotor intervention through neural nociceptive modulation, limbic circuit stabilization, and motor pathway enhancement.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3605-3617"},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}