Journal of Multidisciplinary Healthcare最新文献

{"title":"Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis.","authors":"Nazira B Bekenova, Tamara A Vochshenkova, Aliya Zhylkybekova, Nurgul Ablakimova, Nadiar M Mussin, Rustam K Albayev, Asset A Kaliyev, Amin Tamadon","doi":"10.2147/JMDH.S471606","DOIUrl":"10.2147/JMDH.S471606","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular diseases (CVDs) stand as the foremost global cause of mortality, accounting for 32% of total deaths in 2019, with 85% attributed to heart attacks and strokes. Individuals with Type 2 Diabetes Mellitus (T2DM) exhibit an elevated susceptibility to coronary heart disease (CHD). In numerous studies, it has been established that genetic polymorphism of genes influences the onset, progression, and complications of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). The aims of this study are to employ bibliometric analysis methods for mapping the array of research on genome variability concerning the development of coronary heart disease in individuals with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>We derived the data from the Web of Science (WoS) Core Collection database and Scopus on January 6, 2023. All publications from 1987 to 2023 are exported in plain text format for WoS-CC and BibTeX format for Scopus, containing bibliographic information, keywords, and citation information. RStudio v.4.1.2 software (RStudio, PBC, Boston, MA, USA) was used for conducting bibliometric analysis.</p><p><strong>Results: </strong>Our analysis of 241 articles published between 1987 and 2023 revealed a consistent increase in research output, especially after 2004, highlighting a growing academic focus on genome variability's role in coronary heart disease (CHD) development among Type 2 Diabetes Mellitus (T2DM) patients. Key contributing journals include The Lancet and Nature Genetics, indicating high-impact interest in this domain. The United States leads in research productivity and collaboration, with China also emerging as a notable contributor in recent years. Prominent authors such as S. Humphries have significantly shaped the field, contributing to a cumulative knowledge base that underscores the role of genetic factors in CHD among T2DM patients.</p><p><strong>Discussion: </strong>Our findings underscore the value of bibliometric studies in guiding future research directions. This increasing scholarly attention to genome variability in CHD and T2DM may encourage deeper investigation into specific genetic polymorphisms and their mechanistic roles in disease progression. Additionally, these insights can help prioritize collaboration across leading research hubs and potentially drive innovation in therapeutic interventions targeting genetic risk factors in CHD and T2DM. Future research could build on these trends by focusing on comparative studies across populations, advancing precision medicine approaches for at-risk individuals with T2DM.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5445-5455"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hyperbaric Oxygen Therapy on Patients with SARS-CoV-2 Infection: A Retrospective Cohort Study.","authors":"Pingzhi Wang, Zhengtao Wang, Junyan Zhang, Caiqin Lan, Yani Zhao, Xiaoqing Chen, Yu Li, Qi Mei, Huijing Feng, Shuang Wei, Zhifeng Xue, Fang Gao, Xiaolei Liu, Ying Liang","doi":"10.2147/JMDH.S486170","DOIUrl":"10.2147/JMDH.S486170","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the impact of hyperbaric oxygen therapy (HBOT) on patients with SARS-CoV-2 infection and determine its efficacy and safety in reducing treatment failure events.</p><p><strong>Methods: </strong>A retrospective cohort study involving patients with COVID-19 was conducted. Inverse probability of treatment weighting (IPTW) was used to balance covariates between the HBOT and non-HBOT groups. The primary endpoint was the occurrence of a clinical treatment failure event, defined as all-cause mortality, abandonment of treatment, or transfer to the Intensive Care Unit due to worsening condition.</p><p><strong>Results: </strong>A total of 720 patients with COVID-19 were enrolled in the study, with 27 patients receiving HBOT and 693 patients not receiving HBOT. The occurrence of treatment failure was significantly lower in the HBOT group compared to the non-HBOT group, with no treatment failure events in the HBOT group versus 36 events in the non-HBOT group. The IPTW database analysis results showed that in comparison to the non-HBOT group, the hazard ratio (HR) for treatment failure in the HBOT group was less than 0.001 (95% CI: <0.001 ~ <0.001, p<0.001). Lymphocyte count >0.8×10⁹/L and HBOT was associated with a significantly lower risk of treatment failure. Glucocorticoid use was associated with a higher risk of treatment failure. The incidence of venous thrombosis events was significantly higher in the HBOT group compared to the non-HBOT group.</p><p><strong>Conclusion: </strong>This study revealed that adjunctive HBOT significantly reduces the risk of treatment failure in patients with COVID-19 and is associated with satisfactory safety. HBOT shows promise as a beneficial therapy for improving outcomes in COVID-19-infected patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5501-5511"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Glucose Monitoring: A Transformative Approach to the Detection of Prediabetes.","authors":"Xueen Liu, Jiale Zhang","doi":"10.2147/JMDH.S493128","DOIUrl":"10.2147/JMDH.S493128","url":null,"abstract":"<p><p>Prediabetes, as an intermediary stage between normal glucose homeostasis and overt diabetes, affects an estimated 720 million individuals worldwide, highlighting the urgent need for proactive intervention strategies. Continuous glucose monitoring (CGM) emerges as a transformative tool, offering unprecedented insights into glycemic dynamics and facilitating tailored therapeutic interventions. This perspective scores the clinical significance of even slightly elevated fasting blood glucose levels and the critical role of early intervention. CGM technology provides real-time, continuous data on glucose concentrations, surpassing the constraints of conventional monitoring methods. Both retrospectively analyzed and real-time CGM systems offer valuable tools for glycemic management, each with unique strengths. The integration of CGM into routine care can detect early indicators of type 2 diabetes, inform the development of personalized intervention strategies, and foster patient engagement and empowerment. Despite challenges such as cost and the need for effective utilization through training and education, CGM's potential to revolutionize prediabetes management is evident. Future research should focus on refining CGM algorithms, exploring personalized intervention strategies, and leveraging wearable technology and artificial intelligence advancements to optimize glycemic control and patient well-being.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5513-5519"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Future: A Comprehensive Bibliometric Analysis of Circulating Tumor DNA in Colorectal Cancer.","authors":"Chengzu Wang","doi":"10.2147/JMDH.S493863","DOIUrl":"10.2147/JMDH.S493863","url":null,"abstract":"<p><strong>Purpose: </strong>Colorectal cancer (CRC) is among the most prevalent malignancies worldwide, with rising incidence and mortality rates presenting substantial public health challenges. Traditional detection methods have inherent limitations, which has led to growing interest in liquid biopsy technologies for the identification of circulating tumor DNA (ctDNA). The aim of this study is to explore the developmental trends and future prospects of ctDNA in colorectal cancer through bibliometric analysis.</p><p><strong>Methods: </strong>This bibliometric analysis examines the literature on ctDNA in CRC from 2004 to 2024, utilizing the Web of Science Core Collection database to identify research trends, key areas of interest, and potential future directions. The R package \"bibliometrix\" and VOSviewer software were employed for bibliometric analysis and visualization. The analysis encompassed an evaluation of publication volume, contributing authors, influential journals, country and institutional contributions, and citation metrics.</p><p><strong>Results: </strong>The analysis encompassed a total of 1,054 publications, demonstrating a marked escalation in research activity since 2015. The journal \"Cancers\" has been identified as the most prolific publisher within this domain. Prominent researchers, including Bardelli A and Sartore-Bianchi A, have made substantial contributions to the field. The United States is the leading country in terms of both publication volume and citation frequency, followed by China and Italy. A keyword analysis identified seven conceptual clusters, with \"circulating tumor DNA\" and \"liquid biopsy\" emerging as predominant themes.</p><p><strong>Conclusion: </strong>This study emphasizes the evolving emphasis on the clinical applications of ctDNA, encompassing early detection, treatment monitoring, and prognostic assessment in CRC, thereby underscoring its potential as a non-invasive biomarker in oncology.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5473-5486"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of the ASPECT Score for Predicting Intracranial Hemorrhage Following Intravenous Thrombolysis in Patients with Suspected MCA Infarction: Insights from the Northern Thai Stroke Registry.","authors":"Chutithep Teekaput, Chayasak Wantaneeyawong, Chaiwet Jakrachai, Sarocha Nuttawut, Soraya Nuttawut, Saranya Bowornsomboonkun, Kanokkarn Teekaput, Kitti Thiankhaw","doi":"10.2147/JMDH.S495952","DOIUrl":"10.2147/JMDH.S495952","url":null,"abstract":"<p><strong>Purpose: </strong> The association between the Alberta Stroke Programme Early CT Score (ASPECTS) and intracranial hemorrhage (ICH) in acute ischemic stroke (AIS) patients undergoing thrombolysis remains unclear. This study aimed to determine the relationship between ASPECTS and thrombolysis-associated outcomes, focusing on symptomatic (sICH) and asymptomatic (aICH) ICH.</p><p><strong>Patients and methods: </strong> AIS patients with middle cerebral artery (MCA) territory treated with thrombolysis were enrolled. Patients were categorized into favorable (8-10) and unfavorable (7 or less) ASPECTS. The primary outcomes were sICH and aICH. Secondary outcomes included ICH management, modified Rankin Scale (mRS), and mortality. Multivariable logistic regression analysis evaluated the risk of unfavorable ASPECTS and its association with study outcomes.</p><p><strong>Results: </strong> We included 622 patients (mean age 66.1 ± 13.5 years; 50.5% male); 95 (15.3%) had unfavorable ASPECTS. Patients with unfavorable ASPECTS had higher sICH but not aICH (21.1% vs 4.9%, P < 0.001 and 16.9% vs 17.3%, P = 1.00). Unfavorable ASPECTS was associated with sICH (adjusted odds ratio 5.1; 95% confidence interval 2.7-9.7, P < 0.001). Factors associated with lower ASPECTS included age ≥ 65 years, body weight < 60 kg, atrial fibrillation, onset-to-needle time ≥ 120 minutes, and anemia. Patients with lower ASPECTS had higher mortality and unfavorable mRS (>2) at discharge, 14 days, and 90 days (74.7% vs 50.1%, P < 0.001 for 90-day mRS >2).</p><p><strong>Conclusion: </strong> ASPECTS is a simple tool to predict thrombolysis-associated sICH but not aICH. Patients with unfavorable ASPECTS are at higher risk of complications and poor functional outcomes. Alternative treatments, such as mechanical thrombectomy, might be advisable for these patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5487-5499"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Trends in College Students' Health Education: A Bibliometric Analysis.","authors":"Juan Gao, Jianyi Li, Yuqing Geng, Yan Yan","doi":"10.2147/JMDH.S479983","DOIUrl":"10.2147/JMDH.S479983","url":null,"abstract":"<p><p>This study offers new insights into college students' health education (CSHE) regarding its research status, hot spots, and trends by conducting a comprehensive bibliometric analysis of this field in the past decade (2014 to 2024). Specifically, we analyzed publication trends and used the bibliometric method with CiteSpace software to explore collaborative networks, detailed co-citation status, and co-occurrence dynamics based on 1358 Web of Science Core Collection articles. Our results indicate increased relevant publications and the collaboration networks show complex institutional and regional partnerships. At the same time, co-citation and co-occurrence analyses highlight interdisciplinary research themes that encompass public health. The study particularly underscores the emerging importance of mental health, global health, and innovative educational approaches. These findings reveal trends in CSHE research and provide crucial insights for future studies, stressing the need for interdisciplinary collaboration and creative strategies to tackle student health challenges. Moreover, in practice, this study contributes to promoting and practicing targeted health intervention policies and countermeasures aimed at enhancing student well-being, such as establishing dedicated health education courses, providing specialized training for teachers, conducting regular health assessments, and providing funding for CSHE.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5375-5406"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Hotspots and Frontiers of Patient Delay: A Bibliometric Analysis from 2000 to 2023.","authors":"Fengyan Song, Yuting Yang, Juan Xue","doi":"10.2147/JMDH.S495024","DOIUrl":"10.2147/JMDH.S495024","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the global scientific output of research on patient delay and explore the hotspots and frontiers from 2000 to 2023 through bibliometric analysis.</p><p><strong>Methods: </strong>Publications regarding patient delay published from 2000 to 2023 were extracted from the Web of Science Core Collection (WOSCC). Subsequently, CiteSpace, VOSviewer, and Bibliometrix Online Analysis Platform were used to analyze publications, countries, institutions, authors, journals, and keywords.</p><p><strong>Results: </strong>A total of 721 papers were included in the study. The publication output increased from 20 papers in 2000 to 64 papers in 2023, a remarkable 220.00% growth. The USA (138 papers) and University of California San Francisco (21 papers) were identified as the most productive country and institution, respectively. Moser (10 papers), and Dracup (10 papers) are the most productive authors. \"BMC Public Health\" (24 publications) is the most productive journal. \"Patient Delay\" was the most cited keyword, with high-frequency keywords such as \"Prehospital Delay\", \"Symptoms\", \"Time\", \"Care\", \"Diagnosis\", \"Acute Myocardial-infarction\", and \"Mortality\" signaling hot topics in Patient Delay.</p><p><strong>Conclusion: </strong>There are increasingly many papers on patient delay. However, there has been limited development of cooperation between countries and institutions. In the future, collaboration between countries and institutions should be strengthened. In addition, 3 hotspots and 3 frontiers are summarized in this study to provide researchers with future research directions.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5407-5423"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Technique Reduce Lower Limb Complications After the Traditional No-Touch Technique for Vein Graft Harvesting: A Single-Center Retrospective Historical Controlled Study.","authors":"Teng-Yue Zhao, Bing-Jie Wang, Jiang Liu, Chu Liu, Ji-Qiang Bu, Yu Liu, Fang Yan, Wen-Li Zhang, Zi-Ying Chen, Yu-Ming Wu","doi":"10.2147/JMDH.S492144","DOIUrl":"10.2147/JMDH.S492144","url":null,"abstract":"<p><strong>Objective: </strong>The employment of the no-touch technique in harvesting the great saphenous vein (GSV) for coronary artery bypass grafting has been associated with a significant improvement in clinical patency rates. Despite these advantages, such grafts may predispose patients to complications in the lower limbs. This study endeavors to evaluate the incidence of complications in the lower extremities by deploying an enhanced protocol for the no-touch harvesting technique.</p><p><strong>Methods: </strong>The historical control group in this study included patients who underwent coronary artery bypass grafting (CABG) with the no-touch technique for GSV harvesting at our institution from August 2018 to April 2020, in compliance with ethical standards. The intervention group consisted of patients who received CABG and were subjected to an optimized no-touch technique for GSV harvesting from May 2020 to June 2022. Technical modifications were applied to reduce lower limb complications, including limited use of electrocautery, minimization of extravascular tissue preservation, relaxation of postoperative elastic compression bandages, and elevation of the lower extremities. These measures aimed to decrease the incidence of postoperative lower limb complications, such as pain, numbness, edema, exudation, and delayed healing. The occurrences of postoperative complications were meticulously documented, compared, and analyzed between the two groups.</p><p><strong>Results: </strong>The adoption of the optimized no-touch technique resulted in a significant decrease in the incidence of postoperative lower extremity incisional complications among patients subjected to off-pump CABG (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The results of this study substantiate that the application of an optimized no-touch technique to harvest the GSV significantly diminishes the incidence of postoperative lower limb complications in patients receiving CABG. These results highlight the importance of adopting and integrating this optimized technique into clinical protocols, emphasizing its critical role in advancing patient care outcomes.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5435-5444"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a Missense Mutation in the <i>FLNC</i> Gene from a Chinese Family with Restrictive Cardiomyopathy.","authors":"Jiangtao Dong, Wenjuan Zhang, Qianwen Chen, Lingfeng Zha","doi":"10.2147/JMDH.S494831","DOIUrl":"10.2147/JMDH.S494831","url":null,"abstract":"<p><strong>Objective: </strong>Restrictive cardiomyopathy (RCM) is a heterogenous cardiomyopathy with various causes, and genetic variants take an important part of the pathogenesis. Whole-exome sequencing (WES) is effective to discover genes that cause genetic diseases. By using WES, we attempted to identify the genetic cause of an RCM family and clarify the clinical diagnosis of the patient and then provide a personalized treatment plan.</p><p><strong>Materials and methods: </strong>Blood samples were obtained from the proband and his healthy parents. WES and Sanger sequencing were performed to identify the possible pathogenic gene. Co-segregation analysis was conducted for candidate variants, and the allele frequency was checked in databases including Ensembl, Exome Aggregation Consortium (ExAC) and Human Gene Mutation Database (HGMD). Furthermore, the potential effect of variant was predicted using various-free software such as SIFT, Polyphen-2 and Mutation Taster and the conservation was tested using multiple sequence alignments by ClustalX.</p><p><strong>Results: </strong>The proband was a 20 years old boy with severe heart failure symptoms including dyspnea, massive ascites, edema of both lower limbs and chest congestion. Echocardiography showed significant biatrial enlargement, normal left ventricular wall thickness and preserved systolic function of both ventricles. A missense mutation in <i>FLNC</i> (c.6451G>A, p.G2151S), encoded filamin-C was detected in proband by WES and Sanger sequencing, while it was not be found in his parents, we supposed that the <i>FLNC</i> mutation (c.6451G>A, p.G2151S) may be a de-novo mutation. Through multiple functional predictions, we found that it is a deleterious mutation and the mutation in filamin-C could alter its structure and normal function, contributing to RCM.</p><p><strong>Conclusion: </strong>Here, an <i>FLNC</i> missense mutation (c.6451G>A, p.G2151S) known to be pathogenic in hypertrophic cardiomyopathy, was found to be associated with RCM, indicating the genetic overlap among cardiomyopathies. This study provides insights into Phenotype-Genotype Correlations of RCM in patients with <i>FLNC</i> mutations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5363-5373"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study Protocol for a Randomized Controlled Trial: Evaluating the Impact of Acupuncture on Menstrual Regulation and Pregnancy Enhancement in Patients with DOR Using Rs-fMRI to Assess Brain Functional Networks.","authors":"Tianyu Bai, E Zhou, Kai Wang, Weizheng Li, Jieyu Bi, Jiacheng Ju","doi":"10.2147/JMDH.S490162","DOIUrl":"10.2147/JMDH.S490162","url":null,"abstract":"<p><strong>Background: </strong>Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive way to evaluate brain physiological activity by detecting blood oxygen level fluctuations. Diminished ovarian reserve (DOR) indicates ovarian aging. Before 40, patients may have menstrual abnormalities, poor reproduction, and poor assisted reproductive results. Without treatment, it can cause early ovarian failure. Studies have shown that acupuncture can ameliorate sex hormones and antral follicle count (AFC) in DOR patients.</p><p><strong>Objective: </strong>Despite limited studies on its mechanism, acupuncture have been shown to treat DOR. There is no relevant research on brain functional magnetic resonance and brain functional connectivity of acupuncture in treating DOR. We design this clinical trial to preliminarily elucidate the neuroimaging method of controlling the brain functional network and acupuncture impact in DOR patients using rs-fMRI.</p><p><strong>Methods: </strong>This study will involve 30 DOR patients and 30 healthy individuals. DOR patients will have rs-fMRI before and after 3 menstrual cycles of acupuncture, whereas healthy individuals will need one rs-fMRI scan. The primary end measures will be follicle-stimulating hormone (FSH) and AFC. In contrast, the secondary outcomes will be luteinizing hormone(LH), estradiol (E2), anti-Müllerian hormone (AMH), modified Kupperman scale, self-rating anxiety scale (SAS), self-rating depression scale (SDS), and rs-fMRI alterations.</p><p><strong>Results: </strong>This study uses rs-fMRI technology to identify the brain regions that differ between DOR patients and healthy people before and after acupuncture treatment. This study will connect brain regions, examine the effects of acupuncture on menstruation and pregnancy on DOR patients' brain function networks, and discuss neuroimaging methods.</p><p><strong>Conclusion: </strong>Acupuncture may have the potential to regulate menstruation and increase the chances of pregnancy promotion in patients with DOR.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"17 ","pages":"5425-5434"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}