Journal of Multidisciplinary Healthcare最新文献

{"title":"Latent Profile Analysis of Post-Surgical Psychological Distress in Young Thyroid Cancer Patients and Its Association with Self-Management Efficacy.","authors":"Jia Zhang, Dan Xiong, Chaixiu Li, Dan Li, Yinhuan Wang, Yanmei Fang, Ying Yang","doi":"10.2147/JMDH.S518462","DOIUrl":"10.2147/JMDH.S518462","url":null,"abstract":"<p><strong>Purpose: </strong>Psychological distress (PD) is one of the most prevalent psychological challenges among young patients with thyroid cancer. Recognizing the symptoms of psychological distress among young cancers at different stages is essential for improving their quality of life. This study aims to identify distinct profiles of psychological distress in young thyroid cancer patients post-surgery and assess differences in self-management efficacy across these profiles.</p><p><strong>Methods: </strong>This cross-sectional study was carried out in one general hospital in Chongqing, China. Participants completed the data collection on sociodemographic information, the specific Cancer Distress Scales for Adolescents and Young Adults (CDS-AYA), and the Strategies Used by People to Promote Health (SUPPH). Latent profile analysis was utilized to classify psychological distress into distinct subgroups, and analysis of covariance (ANCOVA) was employed to examine differences in self-management efficacy across these subgroups.</p><p><strong>Results: </strong>A total of 213 valid questionnaires were collected. Ultimately, three distinct profiles of psychological distress were identified: \"low PD group\" (67.1%), \"moderate PD group\" (25.8%), and \"high PD group\" (7.1%). Statistically significant differences were observed among these groups with respect to monthly economic income, underlying diseases, treatment modalities, tumor node metastasis (TNM) staging, and cervical lymph node dissection (F = 36.308, <i>P</i> < 0.001). Additionally, there were statistically significant variations in self-management efficacy scores across the three subgroups.</p><p><strong>Conclusion: </strong>Healthcare professionals ought to implement targeted interventions to tackle the heterogeneity of psychological distress, thereby assisting young with thyroid cancer in lowering their level of psychological distress and enhancing their ability to self-manage their disease.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3345-3356"},"PeriodicalIF":2.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationships of Air Pollution and Meteorological Factors with Acute Aortic Dissection in Urumqi, China: A Distributed Lag Nonlinear Model Analysis.","authors":"Feng-Xia Wang, Qian-Ru Yuan, Jun Cui, Xiao-Qin Ke, Fei-Fei Wang, Xiang-Yu Dong, Ting Wang, Adiya Hahaerman, Yong-Fu Tong, Zhong-Xing Xu, Yan Feng, Yu-Kui Du","doi":"10.2147/JMDH.S509228","DOIUrl":"10.2147/JMDH.S509228","url":null,"abstract":"<p><strong>Objective: </strong>While prior studies link individual meteorological and air quality factors to acute aortic dissection (AAD), their combined lagged effects remain poorly understood. This study evaluates how air pollution and weather conditions collectively influence AAD risk in Urumqi, China.</p><p><strong>Methods: </strong>The results show that the onset of AAD predominantly occurs in the cold season, exhibiting distinct seasonal characteristics. Meanwhile, PM2.5, PM10, SO2, and the average dew point are significantly correlated with an increased risk of AAD. Males are more sensitive to certain pollutants (PM2.5, PM10, SO2) and the average dew point. In contrast, in females, CO surprisingly has a protective effect. Among people aged ≤ 50, O3_8h and the average dew point have a strong cumulative correlation with the incidence of AAD, while CO exposure and the maximum sustained wind speed are negatively correlated with the incidence of AAD. Individuals aged over 50 show little sensitivity to air pollutants and meteorological conditions. Under extreme conditions, the concentrations of PM2.5, SO2, and PM10 can still increase the risk of AAD onset.</p><p><strong>Conclusion: </strong>Air pollution and meteorological factors significantly impact AAD risk, highlighting the need to consider these factors in prevention and management strategies.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3331-3343"},"PeriodicalIF":2.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Shared Decision-Making-Based Exercise Management Program on Blood Glucose Control in Patients with Gestational Diabetes Mellitus.","authors":"Bei Liu, Ge Jia, Fengcheng Cai","doi":"10.2147/JMDH.S525616","DOIUrl":"10.2147/JMDH.S525616","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the application of a shared decision-making (SDM)-based exercise management program in patients with gestational diabetes mellitus (GDM) and its impact on blood glucose control.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 88 GDM patients who delivered at the Hangzhou Women's Hospitalbetween December 2022 and April 2024. Patients were divided into the control group (n=44, receiving conventional exercise management program) and the observation group (n=44, receiving SDM-based exercise management program). Compliance with medical advice, quality of life (DSQL), self-management ability (SDSCA), blood glucose indicators (FBG, 2 h PG, and HbAlc), adverse self-management behaviors, and maternal and neonatal pregnancy outcomes were compared between the two groups.</p><p><strong>Results: </strong>The observation group had higher rates of standardized medication use, scientific diet, regular blood glucose monitoring, adherence to exercise, and regular sleep patterns compared to the control group (P<0.05). After intervention, the DSQL scores in both groups decreased, while the SDSCA scores increased, with the observation group showing a greater change (P<0.05). The FBG, 2 h PG, and HbAlc levels were all lower after intervention in both groups, with the observation group showing a greater change (P<0.05). The observation group had lower rates of poor blood glucose control, excessive weight gain during pregnancy, and unsatisfactory post-delivery oral glucose tolerance test (OGTT) compared to the control group (P<0.05). The total incidence of adverse maternal pregnancy outcomes and neonatal adverse pregnancy outcomes was also lower in the observation group compared to the control group (P<0.05).</p><p><strong>Conclusion: </strong>Compared to conventional exercise management programs, the SDM-based individualized exercise management program can further improve GDM patients' compliance with medical advice, enhance self-management abilities and quality of life, regulate blood glucose control, and improve maternal and neonatal pregnancy outcomes.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3311-3320"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Healthcare Agility: A Strategic Framework for Pandemic-Responsive Operational Planning.","authors":"Abdullah Alrabghi, Abdullah Tameem","doi":"10.2147/JMDH.S524619","DOIUrl":"10.2147/JMDH.S524619","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has challenged healthcare systems globally, testing their resilience due to sudden fluctuations in confirmed cases, intensive care unit utilization, and medical team availability. These dynamics forced healthcare facilities to continuously adapt their operational plans.</p><p><strong>Methods: </strong>This research conducts a comprehensive review of published changes implemented by various healthcare facilities in response to the pandemic.</p><p><strong>Results: </strong>The study provides new insights into enabling healthcare agility during pandemics such as COVID-19. A decision-making framework is proposed to assist hospital management in exploring and selecting appropriate alternatives, allowing faster adaptation in dynamic environments.</p><p><strong>Discussion: </strong>The framework can be tailored to each hospital's unique characteristics and the prevailing epidemiological situation. Future research could explore the use of simulation to automate the development of dynamic operational plans based on pre-selected criteria, further enhancing healthcare responsiveness.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3321-3330"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Ocular Manifestations in Acute Leukemia: Clinical Patterns and Hematologic Correlates.","authors":"Bo-Jing Yan, Li-Hua Luo, Jing Shen, Ying-Xiang Huang","doi":"10.2147/JMDH.S522369","DOIUrl":"10.2147/JMDH.S522369","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical manifestations of secondary ocular changes in acute leukemia, classify these based on disease progression, investigate the etiology and treatment options for this rare retinal disease, and provide references for clinical management.</p><p><strong>Methods: </strong>This cohort study was conducted in collaboration between the Department of Ophthalmology and Hematology at Beijing Friendship Hospital, Capital Medical University. A total of 74 acute leukemia patients admitted to the Hematology Department from January 2018 to September 2023 were enrolled. Ocular screenings were performed, and 34 patients with ocular symptoms were categorized and followed up. Clinical data differences were statistically analyzed based on hematologic diagnosis, and ocular manifestations and treatment outcomes were observed to identify optimal treatment approaches.</p><p><strong>Results: </strong>Among the 74 patients, 34 (45.9%) exhibited ocular manifestations, with the majority being retinal changes (91.2%), mainly retinal hemorrhage or vascular occlusion. Ocular involvement in AML and ALL patients was classified into three severity levels, each corresponding to different treatments. Red blood cell hematocrit, white blood cell count, and platelet count were compared between AML and ALL patients with and without ocular involvement. Results showed that AML and ALL patients with retinal hemorrhage had lower hematocrit than those without ocular involvement (P<0.05). Platelet counts were higher in AML and ALL patients with Roth spots than in those without ocular involvement (P<0.05).</p><p><strong>Conclusion: </strong>Acute leukemia remains a rare condition in ophthalmology practice in China. This study fills a diagnostic gap, providing valuable theoretical support for clinicians in terms of etiology, clinical manifestations, and treatment strategies.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3289-3297"},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Cognitive-Behavioral Intervention (CBI) on Enhancing Mental Health and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy Nursing.","authors":"Miaoxin Fan, Xiuli Wei","doi":"10.2147/JMDH.S527594","DOIUrl":"10.2147/JMDH.S527594","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the impact of cognitive behavior intervention (CBI) on the mental health and quality of life of patients with lung cancer.</p><p><strong>Methods: </strong>A retrospective study was conducted involving 80 lung cancer patients admitted to Taihe County People's Hospital between June 2022 and June 2023. Patients were divided into two groups: an experimental group receiving CBI and a comparison group receiving conventional care only, with 40 patients in each group. Mental health was evaluated using the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). The Simplified Health Survey Scale (SF-36) was utilized to assess overall quality of life across eight dimensions: physical functioning, role limitations due to physical health, bodily pain, general health, vitality, social functioning, role limitations due to emotional problems, and mental health. Additionally, patient satisfaction with nursing care was measured. Demographic characteristics, including age and gender distribution, were recorded for both groups.</p><p><strong>Results: </strong>Baseline characteristics of the total study population (n=80) were documented, including age, sex, and lung cancer stage. The mean age of the participants was 60.16 ± 9.13 years.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3299-3309"},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of Acupuncture Treatment of Postoperative Complications from 2003 to 2023.","authors":"Daocheng Zhu, Wei Xu, Wenguo Ye, Yuexia Jiang, Lin Jiao, Rixin Chen","doi":"10.2147/JMDH.S528696","DOIUrl":"10.2147/JMDH.S528696","url":null,"abstract":"<p><strong>Background: </strong>Postoperative complications refer to some related clinical symptoms that occur after surgery, which can affect7 the patient's recovery. Acupuncture has a good effects on postoperative complications, which can accelerate postoperative recovery. Currently, there are many literature studies in this field. However, there has been no quantitative analysis of these literature. Therefore, in this study, the bibliometric method was adopted to analyze the relevant literature, thereby exploring the research hotspots and trends in this field.</p><p><strong>Methods: </strong>Through the web of science core database, we collected the relevant literature on the acupuncture treatment of postoperative complications from 2003 to 2023, used citespace software to analyze the author, publishing institution, country, keywords, references, cited journals and other information of these literature, and analyzed its research hotspots and research trends through a visual view.</p><p><strong>Results: </strong>A total of 213 articles were obtained, and the annual publication volume overall is on the rise, especially in recent years when the publication volume has surged. The field with the highest number of publications is Integrative Complementary Medicine. The most cited journal is Evidence-Based Complementary and Alternative Medicine. The country with the highest number of publications is China, and the institution with the highest number of publications is Capital Medical University. The author with the highest number of publications is Zhu, Junchao. The most central cited author is LEE A. The articles with the highest frequency and centrality of cited references are published by Liu, Y. H. The most frequently studied keywords are acupuncture.</p><p><strong>Conclusion: </strong>This study systematically analyzes the current research status and hotspots of acupuncture treatment for postoperative complications in the past 20 years, which can help researchers grasp the current research direction and provide reference basis for further research.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3269-3287"},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12154538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Bibliometric Analysis of Cardiovascular Disease Risk in Obesity (2014-2024).","authors":"Hang Yang, Tao Zhang, Dongyang Wang, Edmund Loi, Qixiang Geng, Baoling Wu, Xi Wang, Rongjiang Cai","doi":"10.2147/JMDH.S504022","DOIUrl":"10.2147/JMDH.S504022","url":null,"abstract":"<p><strong>Background: </strong>Obesity, as a global chronic disease, is causing an increasing risk of cardiovascular disease. This study used bibliometrics to synthesize and analyze publications related to obesity and cardiovascular risk from 2014 to 2024. It aimed to clarify the current status of research, predict future trends, and provide a scientific basis for prevention and treatment.</p><p><strong>Methods: </strong>In this study, we used bibliometrics online analysis platform, Citespace (version 6.3.R1, LLR algorithm) and VOSviewer (version 1.6.20) software to analyze the co-occurrence network analysis of publications related to cardiovascular risk of obesity in worldwide for countries, institutions, authors, and journals from January 2014 to September 2024, and keyword co-occurrence, clustering, and burst analysis were performed to reveal research trends and hotspots.</p><p><strong>Results: </strong>A total of 1492 articles related to cardiovascular risk in obesity were selected for this study, and in terms of the number of publications showed a steady increase over time. Based on keyword clustering analysis, the field can be summarized into two research themes: the field of the relationship between health indicators such as BMI, waist circumference, cardiovascular disease, and the field of metabolism and obesity-related issues. According to the keyword burst analysis, the keywords cholesterol, oxidative stress, non-alcoholic fatty liver disease, and ratio to height became prominent and will be the main research hotspots in the future.</p><p><strong>Conclusion: </strong>In recent years, there has been a rapid increase in cardiovascular risk research in obese patients. This article reveals the remarkable progress and dynamic trends in this field, providing strong support for exploring new directions, as well as laying a data foundation for public health policy development and interdisciplinary collaboration. Future research should prioritize focusing on mechanism exploration and clinical application of novel drugs to promote health improvement.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3233-3255"},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice of Medical Staff Towards Metabolic Syndrome in Schizophrenia in Chinese Hospitals: A Cross-Sectional Study.","authors":"Yuejia Wang, Xuefen Yu, Haiqin Chen, Chunxia Tang, Na Zhang","doi":"10.2147/JMDH.S503664","DOIUrl":"10.2147/JMDH.S503664","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the knowledge, attitude, and practice (KAP) of medical staff regarding metabolic syndrome in schizophrenia in Chinese hospitals, emphasizing implications for improving clinical management.</p><p><strong>Methods: </strong>This multicenter, cross-sectional study enrolled medical staff in 5 hospitals between March 2024 and April 2024. A self-administered questionnaire was developed to collect the demographic information and KAP scores of the participants.</p><p><strong>Results: </strong>A total of 359 valid questionnaires were analyzed, with 280 respondents (77.99%) being female and 298 (83.01%) employed in public tertiary hospitals. Mean scores for knowledge, attitude, and practice were 30.93±7.45, 28.81±3.60, and 22.50±5.11, respectively. The proportion of participants achieving good levels of knowledge, attitude, and practice (defined as scores ≥60% of the maximum score) was 75.77%, 99.72%, and 88.58%, respectively. Multivariate logistic regression identified several factors independently associated with practice: higher knowledge scores (OR = 1.16), positive attitude scores (OR = 1.09), being female (OR = 2.64), having ≥16 years of experience (OR = 3.24), and previous experience in managing patients with metabolic syndrome in schizophrenia (OR = 0.50). Approximately 64.9% of participants had experience treating patients with schizophrenia and metabolic syndrome, and this experience was significantly associated with higher practice scores. Structural equation model analysis revealed that knowledge influenced attitude (β = 0.10), attitude influenced practice (β = 0.82), and knowledge directly influenced practice (β = 0.50).</p><p><strong>Conclusion: </strong>Medical staff possess adequate knowledge, positive attitude, and proactive practice concerning metabolic syndrome in schizophrenia. Although the overall level of KAP was good, there is still room for further improvement. The findings suggest targeted interventions, such as continuous education programs and training tailored for Chinese medical staff, could enhance their proactive practices in managing metabolic syndrome in schizophrenia patients.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3257-3268"},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.","authors":"Shuang Chen, Shihao Sun, Zihan Zhou, Zhaokai Zhou, Ran Zhang, Wenyan Song, Hang Xin, Qingling Yang, Shanjun Dai, Kai Huang, Wenbin Niu, Hao Shi, Yihong Guo","doi":"10.2147/JMDH.S524949","DOIUrl":"10.2147/JMDH.S524949","url":null,"abstract":"<p><strong>Background: </strong>Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.</p><p><strong>Methods: </strong>Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). Causal links were decrypted using genome-wide association study (GWAS) data. Sensitivity analyses were performed to assess the strength, heterogeneity, and horizontal pleiotropy of the results.</p><p><strong>Results: </strong>For AS, 34 causal relationships were identified, with BAFF-R, CD20, and CD27 in the B-cell panel having protective effects against AS. A crucial causative connection between <i>CD11c+ CD62L- monocyte%monocyte</i> (cDC panel) and AS pathogenesis was also revealed. For PCOS, 40 causal effects were established, with CD20, CD24, and CD27 in the B-cell panel playing different roles in PCOS. <i>CD4 on CM CD4+</i> (maturation stages of the T-cell panel) significantly increased the risk of PCOS. For SA, 33 causative associations were determined, and a protective effect of <i>CCR2 (C-C chemokine receptor type 2) on CD14+ CD16+ monocytes</i> (monocyte panel) in SA was particularly noted. The diverse functions of the CD28, CD39, and CD25 molecules in the Treg cell panel in SA were also observed.</p><p><strong>Conclusion: </strong>This study comprehensively evaluated the causal impact of immune traits on reproductive illnesses, stressing the complex and important role of immunogenic factors in pathogenesis and highlighting a novel direction for clinical work.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"3219-3232"},"PeriodicalIF":2.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}