Journal of Multidisciplinary Healthcare最新文献

{"title":"Acute Nomophobia and Its Psychological Correlates in Adolescents: An Explanatory Sequential Mixed-Methods Approach.","authors":"Dua'a Fayiz Al Maghaireh, Najah Sami Shawish, Andaleeb M Abu Kamel, Mariam Kawafha","doi":"10.2147/JMDH.S505535","DOIUrl":"10.2147/JMDH.S505535","url":null,"abstract":"<p><strong>Background: </strong>Nomophobia is a recent medical term; it is a combination of \"no-mobile\" and \"phobia\". Nomophobia encompasses feelings of fear, anxiety, and discomfort stemming from the absence of a mobile device or the inability to access one, when necessary, as well as the apprehension of disconnection from the digital realm. It's correlated with many psychological problems.</p><p><strong>Aim: </strong>This study aimed to explore the impact of nomophobia and its psychological correlates, particularly stress, loneliness, and depression, among adolescents.</p><p><strong>Methods: </strong>Explanatory sequential mixed-methods design was used. A sample of 180 students were participated. They completed the Nomophobia Questionnaire, Perceived Stress Scale, Beck Depression Inventory, and UCLA Loneliness Scale, followed by semi-structured interviews with 30 students exhibiting high levels of nomophobia.</p><p><strong>Results: </strong>The study found that the majority of students (76.7%) exhibited high levels of nomophobia, with a higher prevalence among females (78.72%) compared to males (69.76%). Students reported high levels of stress (mean = 32.96, SD = 1.35) and social loneliness (mean = 67.9, SD = 4.17), while depression levels were low (mean = 7.03, SD = 4.1). Female students experienced higher levels of stress and loneliness than their male counterparts. Stress and social loneliness were identified as significant predictors of nomophobia, with positive associations (coefficients: 1.64 and 1.20, respectively) and strong correlations (<i>R²</i> = 0.93 and 0.98, p = 0.01). Depression showed a negative but non-significant association with nomophobia (-0.43, p = 0.06). The qualitative results reveal four major themes: compulsive phone behaviors, emotional issues, health concerns, and behavioral problems.</p><p><strong>Conclusion: </strong>Nomophobia significantly affects the emotional, physical, and social health of students, highlighting the necessity for specific strategies aimed at addressing smartphone addiction and fostering more positive digital behaviors within this age group.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1445-1460"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics and Synbiotics: Applications, Benefits, and Mechanisms for the Improvement of Human and Ecological Health.","authors":"Ankita Bhatia, Deeksha Sharma, Jyoti Mehta, Vinoth Kumarasamy, M Yasmin Begum, Ayesha Siddiqua, Mahendran Sekar, Vetriselvan Subramaniyan, Ling Shing Wong, Nur Najihah Izzati Mat Rani","doi":"10.2147/JMDH.S501056","DOIUrl":"https://doi.org/10.2147/JMDH.S501056","url":null,"abstract":"<p><p>This review explores the multifaceted roles and applications of probiotics, emphasizing their significance in maintaining and enhancing host health through microbial interactions. It includes the concept of holobionts and the symbiotic relationships between hosts and their microbiomes, illustrating how various microbiota can enhance immunity, support growth, and prevent diseases. It delves into the customization of probiotics using molecular and genomic techniques, focusing <i>Enterococcus, Bifidobacterium</i>, and <i>Lactobacillus</i> species. Furthermore, it discusses the symbiotic effects of symbiotics which aids in enhancing the survivability and beneficial effects of probiotics. The role beneficial microbes in gut is emphasized, noting its impact on preventing diseases and maintaining a stable microbial community. The potential therapeutic value of probiotics includes the ability to treat gastrointestinal diseases, as well as to strengthen the immune system and reduce the number of free radicals that are present in the body. Additionally, it explores secondary metabolites produced by bacteria in the gut, such as bacteriocins and exopolysaccharides, and their effect on the health of human, particularly in the gastrointestinal tract. The review concludes by addressing the use of probiotics in traditional medicine and their potential in novel therapeutic applications, including the treatment of endangered wildlife species and various human ailments.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1493-1510"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Needs and Wishes of Older Adults in Interprofessional Treatment for Malnutrition and Sarcopenia: A Grounded Theory Study.","authors":"Sandra D Boxum, Sabien H Van Exter, Jan-Jaap Reinders, Hans Drenth, Manon G A Van den Berg, Michael Tieland, Anjo Geluk-Bleumink, Sophie L W Spoorenberg, Evelyn Finnema, Philip J Van der Wees, Niek Koenders, Harriët Jager-Wittenaar","doi":"10.2147/JMDH.S507567","DOIUrl":"https://doi.org/10.2147/JMDH.S507567","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition and sarcopenia impact the physical health and quality of life of community-dwelling older adults. Managing these conditions requires integrating nutritional and exercise interventions delivered by professionals from diverse backgrounds. Interprofessional collaboration holds promise for providing integrated, person-centered care to older adults. However, to tailor such care, it is essential to understand the needs and wishes of older adults, which remain underexplored. This study aimed to understand the needs and wishes of community-dwelling older adults regarding interprofessional treatment for (risk of) malnutrition and sarcopenia.</p><p><strong>Methods: </strong>We conducted a grounded theory study. Data collection involved semi-structured interviews and focus groups with community-dwelling older adults who are undergoing treatment or have been treated for (risk of) malnutrition and/or sarcopenia. We systematically analyzed the data using open, axial, and selective coding and developed a conceptual model.</p><p><strong>Results: </strong>Interviews and focus groups were conducted with 18 older adults. Three selective codes were identified: 1) older adults need to be involved in their interprofessional treatment, 2) older adults need healthcare professionals to be well-informed about their interprofessional treatment, and 3) older adults need collaboration amongst involved healthcare professionals in interprofessional treatment. Our conceptual model addresses the needs and wishes of older adults in relation to interprofessional collaboration. Older adults' needs highlight what is missing, while their wishes offer ways to fulfill these needs.</p><p><strong>Conclusion: </strong>Older adults' need for involvement in interprofessional treatment can be met by engaging them actively in healthcare decisions and as partners to healthcare professionals. The need for well-informed healthcare professionals can be fulfilled by ensuring accessible healthcare information, the prevention of conflicting advice, and the prevention of repeating medical history. Finally, the need for collaboration among healthcare professionals can be fulfilled by healthcare professionals communicating openly and directly and working closely together.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1433-1444"},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Differences in Necessary Competencies, Skills, and Performance Abilities Among Thai Board-Certified Occupational Medicine Physicians and Basic Occupational Medicine Certified Physicians.","authors":"Pachara Sasanawin, Vithawat Surawattanasakul, Shewarat Prasan, Kitipong Banomyong","doi":"10.2147/JMDH.S509530","DOIUrl":"10.2147/JMDH.S509530","url":null,"abstract":"<p><strong>Background: </strong>Occupational physicians in Thailand are classified into two groups: Thai board-certified occupational medicine physicians (TBOMPs) and Basic occupational medicine certified physician (BOMCPs). Variations in training duration result in differences in professional competencies. Although national regulations allow both groups to perform similar duties, disparities in training have raised concerns regarding competency, necessitating further investigation.</p><p><strong>Purpose: </strong>To explore the necessary competencies, skills, and abilities to perform in occupational medicine in TBOMPs and BOMCPs.</p><p><strong>Patients and methods: </strong>An analytic cross-sectional survey was conducted using an anonymous online questionnaire distributed via the Redcap platform to TBOMPs end BOMCPs across institutions. The questionnaire was developed based on several standardized sources of core competencies, is divided into three sections, which include: demographic and working conditions, necessary competencies and skills, and abilities to perform in occupational medicine.</p><p><strong>Results: </strong>A total of 216 respondents participated in the study, comprising 58 TBOMPs and 158 BOMCPs. The TBOMPs had a slightly higher proportion of males than the BOMCPs (67.2% vs 53.2%) and a marginally lower mean age (34.84 ± 8.59 vs 37.67 ± 8.69 years). As regards necessary competencies, TBOMPs significantly rated four areas higher than BOMCPs which include diagnosis of work-related diseases (4.57 vs 4.43, p = 0.032), ergonomics (4.38 vs 4.10, p = 0.005), medical surveillance and prevention (4.63 vs 4.48, p = 0.034), and communication skills (4.81 vs 4.57, p = 0.001). Additionally, as regards the abilities to perform, TBOMPs rated all areas higher than BOMCPs except for diagnosing work-related diseases (93.1% vs 81.7%, p = 0.053), and leadership and teamwork (91.4% vs 87.3%, p = 0.481).</p><p><strong>Conclusion: </strong>HRM, communication, teamwork, and leadership are essential competencies and skills. Enhancing training in environmental medicine, revising research methodology instruction, and introducing refresher training sessions in the The Residency Training Program of Occupational Medicine (ROM) and Basic occupational medicine (BOM) curricula are recommended to improve professional practice.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1423-1432"},"PeriodicalIF":2.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of The Mindfulness-Based Relaxation, Aromatherapy, and Prayer (RADO) Intervention on Anxiety and Quality of Life Among Children With Cancer.","authors":"Dyna Apriany, Windy Rakhmawati, Aulia Iskandarsyah, Dany Hilmanto","doi":"10.2147/JMDH.S507759","DOIUrl":"10.2147/JMDH.S507759","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the effectiveness of a novel mindfulness-based intervention called RADO (Relaxation, Aromatherapy, and Prayer) for reducing anxiety and improving the quality of life in children with cancer.</p><p><strong>Patients and methods: </strong>A quasi-experimental pre- and post-control group design was used. Participants included 66 children with cancer aged 10-17 years, diagnosed with cancer for at least 3 months, currently undergoing treatment, and able to communicate verbally, and recruited from three hospitals in Bandung, Indonesia. The study used consecutive sampling. The intervention group received a seven-day RADO program involving mindfulness-based relaxation, aromatherapy, and prayer. Anxiety and QoL were measured using the Hamilton Rating Scale for Anxiety (HRS-A) and Pediatric Quality of Life Inventory (PEDQL 3.0), respectively. Data were collected at baseline (T0), day three (T1), and day seven (T3). Statistical analysis included repeated ANOVA and independent t-tests.</p><p><strong>Results: </strong>By day seven (T3), the intervention group showed a significant reduction in anxiety (p < 0.001) and improved QoL (p = 0.001) compared to the control group. Repeated ANOVA revealed significant within-group changes in the intervention group across time points, while no significant changes were observed in the control group. Following the intervention, males and a diagnosis of ALL demonstrated slightly higher anxiety scores and quality of life scores than female and those with other cancer types. Additionally, individuals who underwent fewer chemotherapy cycles (<10) showed better outcomes in anxiety and quality of life than those with 10 or more cycles.</p><p><strong>Conclusion: </strong>The RADO intervention significantly reduced anxiety and enhanced QoL among pediatric cancer patients, demonstrating its potential as a culturally tailored MBI for children undergoing cancer treatment. Further research is needed to explore long-term effects and cross-cultural adaptability.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1381-1392"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences, Challenges, and Needs of People Living with HIV in Hunan Province, China: A Qualitative Study.","authors":"Chunhong Shi, Xiya Li, Yehua Dai, Ming Chen, Lin Mao, Xinyue Zhou, Yanzhi Lei, Wenxia Yuan","doi":"10.2147/JMDH.S512278","DOIUrl":"10.2147/JMDH.S512278","url":null,"abstract":"<p><strong>Background: </strong>Globally, the human immunodeficiency virus (HIV) epidemic continues to pose significant challenges. In China, the differentiated services delivery (DSD) model has been implemented to improve healthcare for people living with HIV (PLHIV). However, challenges persist in fully implementing and scaling up the DSD model. Given the knowledge gaps and the need for better strategies to support this vulnerable population, our study aimed to explore the experiences, challenges, and needs of PLHIV to inform the development of patient-centered healthcare services.</p><p><strong>Methods: </strong>We employed a qualitative design to interview 20 PLHIV from July 27 to October 13, 2024, in the Infectious Disease Ward at the Second People's Hospital in Chenzhou, Hunan Province. Individual face-to-face in-depth interviews were conducted to collect data. Colaizzi's seven-step analysis method and NVivo 14 was used to analyze the transcripts.</p><p><strong>Results: </strong>The participants, aged 23 to 83 years, had been living with HIV for durations ranging from one month to 19 years. The interview data revealed four themes: (1) the <i>physiological</i> dimension: multi-organ physical symptoms, increased physical vulnerability, and a desire for healthcare guidance; (2) the <i>psychological</i> dimension: emotional distress, inadequate HIV-related knowledge, considerable stigma and discrimination, and a desire for respect and dignity; (3) the <i>societal</i> dimension: huge economic burden, fragile social networks, and a desire for social support; and (4) the <i>spiritual</i> dimension: mixed feelings about death, negative expectations of the future, seeking solace in faith, and a desire for a \"good\" death.</p><p><strong>Conclusion: </strong>PLHIV in this study have undergone complex journeys across physical, psychological, societal, and spiritual dimensions, expressing urgent needs for support from various stakeholders. Our findings highlight the urgency of implementing patient-centered care, enhancing psychological support, reducing discrimination, and providing robust social and spiritual care through stakeholder collaboration to optimize the DSD model and resource allocation.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1405-1421"},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Four-Stage Death Education Model Based on Constructivist Learning Theory for Trainee Nursing Students.","authors":"Yujing Yang, Yue Li, Jia Fu, Dan Guo, Jingjing Xue","doi":"10.2147/JMDH.S500169","DOIUrl":"10.2147/JMDH.S500169","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effectiveness of the four-step death education model based on constructivist learning theory in enhancing the death coping abilities and attitudes of trainee nurses and improving course satisfaction.</p><p><strong>Methods: </strong>Sixty-six trainee nurses from a tumour hospital in Shanxi Province were selected as the study subjects, and a class-experimental research design was adopted, in which the nursing students before the course implementation were taken as the control group and those after the course implementation were taken as the experimental group. Death Attitude Profile Revised Scale (DAP) was used to measure the cognitive attitude of nursing students towards death, and a self-made questionnaire was used to test the satisfaction of nursing students with the curriculum design. Paired sample <i>t</i> test was used to compare the participants before and after the study.</p><p><strong>Results: </strong>Post-course death avoidance score, fear of death score, and escape-orientated death acceptance score of the trainee nurses (all <i>P</i><0.05) were higher than the control group. Neutral death acceptance score (<i>P</i><0.05) was lower amongst the trainee nurses than the control group after the course. It showed that the attitudes towards death of the trainee nurses before and after the course improved in terms of fear and anxiety, sense of avoidance, and neutral acceptance. In the evaluation of the content of the course, the teaching methods of the course, and the teaching results, most of the trainee nurses gave a better evaluation.</p><p><strong>Conclusion: </strong>The four-step death education model based on constructivist learning theory significantly improved the death coping skills and attitudes of trainee nursing students. Although this educational model is still limited, it provides research materials for the future establishment of a systematic death education.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1371-1380"},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.","authors":"Alexander Halim Santoso, Edwin Destra, Yohanes Firmansyah, Susy Olivia Lontoh","doi":"10.2147/JMDH.S486370","DOIUrl":"10.2147/JMDH.S486370","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia, characterized by a progressive decline in muscle mass and strength, poses significant public health challenges for the elderly, impacting physical performance and quality of life. This study aims to investigate the associations between glucose profile, fasting insulin, renal function, and muscle strength among elderly residents of a single-centered nursing home in Indonesia, identifying potential biomarkers for sarcopenia.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on 31 elderly residents of Santa Anna Nursing Home, with muscle strength measured using handgrip dynamometry and biochemical parameters evaluated through standardized laboratory methods.</p><p><strong>Results: </strong>Structural Equation Modeling-Partial Least Squares (SEM-PLS) analysis revealed strong negative correlations between glucose profile (β = -0.683, p < 0.01) and fasting insulin (β = -0.208, p < 0.05) with muscle strength, while renal function showed a moderate positive relationship (β = 0.295, p < 0.05).</p><p><strong>Conclusion: </strong>These findings highlight glucose profile, fasting insulin, and renal function as critical predictors of sarcopenia, offering potential pathways for early detection and targeted interventions. Future research should explore longitudinal assessments and molecular mechanisms to refine sarcopenia prevention strategies in aging populations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1393-1404"},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality in an Asthmatic Adult Population in Saudi Arabia: A Cross-Sectional Study.","authors":"Tareq F Alotaibi, Saleh S Algarni, Mohammed M Alqahtani, Hassan Y Aljohani, Taha T Ismaeil, Mobarak K Alqahtani, Riyadh Abdullah Alotaibi, Abdullah H Alateeq, Fahad Saad Al-Dawsari, Mansour M Alotaibi, Mohammed F Alshahrani, Turki M Alanazi, Abdullah M Alanazi","doi":"10.2147/JMDH.S480326","DOIUrl":"10.2147/JMDH.S480326","url":null,"abstract":"<p><strong>Background & aims: </strong>Asthma is a chronic disorder affecting health-related quality of life. This study aimed to explore differences in sleep quality based on individual characteristics, such as smoking habits and asthma.</p><p><strong>Methods: </strong>This cross-sectional study included Saudi citizens aged ≥18 years. A questionnaire was used to collect information regarding demographics, sleep quality, smoking history, and physical activity.</p><p><strong>Results: </strong>We included 489 participants (male, 58%), divided into three main groups for analysis: (1) individuals with asthma (n=52), smokers (n=104), and controls (n=333). In total, 71.15% (n=37) of individuals with asthma and 64.4% (n=67) of the smokers had sleep difficulties. Furthermore, 61.5% (n=32) of individuals with asthma and 56.7% (n=59) of smokers were found to be insufficiently active. Additionally, 15.4% (n=8) of individuals with asthma and 15.4% of smokers (n=16) were moderately active. Finally, 23.1% (n=12) of individuals with asthma and 27.9% (n=29) of smokers were active. The questionnaire also revealed that 57.7% (n=282) of respondents had poor sleep quality, with a significantly higher rate among individuals with asthma (71.15%; n=37; mean ± SD: 10 ± 3.57) compared to that among non-asthmatics (50%; n=245; mean ± SD: 6.58 ± 3.61; <i>P</i>=0.027).</p><p><strong>Conclusion: </strong>Asthma has a significant impact on sleep quality and physical activity levels. Poor sleep quality adversely affects the quality of life, suggesting that increased public awareness of these risk factors is crucial.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1345-1351"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Energy Metabolism-Related Subtypes and Diagnostic Biomarkers for Osteoarthritis by Integrating Bioinformatics and Machine Learning.","authors":"Sheng Xu, Jie Ye, Xiaochong Cai","doi":"10.2147/JMDH.S510308","DOIUrl":"10.2147/JMDH.S510308","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a chronic and complex degenerative joint disease that increasingly burdens and affects the elderly population. Abnormal energy metabolism is closely associated with the pathological mechanisms of OA. This study aims to identify key genes related to energy metabolism that are closely linked to the treatment and diagnosis of OA.</p><p><strong>Methods: </strong>The transcriptomic data for OA were collected from the Gene Expression Omnibus (GEO), with GSE51588 and GSE63359 serving as the training and validation datasets, respectively. Differential expression analysis was conducted to identify key energy metabolism-related genes. Unsupervised clustering was performed to classify molecular subtypes. Three machine learning algorithms were employed to identify key diagnosis genes, specifically Least Absolute Shrinkage and Selection Operator (LASSO), Support Vector Machine Recursive Feature Elimination (SVM-RFE), and Random Forest (RF). We construct a comprehensive nomogram, and the diagnostic performance of both the nomogram and feature genes was evaluated using operating characteristic curve (ROC) and calibration curves. We assessed the immune infiltration levels in OA samples using the IOBR platform and the CIBERSORT algorithm.</p><p><strong>Results: </strong>We classified OA patients into two molecular subtypes, which exhibited distinct differences in immune infiltration levels. Subsequently, we successfully identified two characteristic genes, NUP98 and RPIA, and demonstrated statistically significant differences (P < 0.05) and diagnostic performance in the validation cohort. Evaluation using ROC and calibration curves demonstrated that these characteristic genes exhibit robust diagnostic performance. Multiple immune cells may be involved in the development of OA, and all characteristic genes may be associated with immune cells to varying degrees.</p><p><strong>Conclusion: </strong>In conclusion, NUP98 and RPIA have the potential to serve as diagnostic biomarkers for OA and may offer opportunities for therapeutic intervention in OA.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1353-1369"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}