Mapping the Brain's Role in Osteoarthritis: New Evidence for Prevention.

IF 2.7 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Journal of Multidisciplinary Healthcare Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S522952

Jingkai Di, Yujia Xi, Yaru Liu, Likun Qi, Shuai Chen, Yingda Qin, Chuan Xiang

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引用次数: 0

Abstract

Purpose: This study explores the causal link between brain structural parameters and Osteoarthritis (OA), aiming to prevent OA progression.

Patients and methods: We used two-sample Mendelian randomization. In addition to European OA data with a sample size of 484,598, Firth correction OA data from the same source, and SPA correction OA data were included as outcome data. 3913 brain imaging-derived phenotypes (IDPs) from the UK Biobank were used as exposure data. Weighted median, MR Egger, and IVW validated causal correlations. Analyses of sensitivity and heterogeneity validated the robustness of the findings.

Results: Thirteen brain regions significantly linked to OA. Increased fractional anisotropy (FA) in the cingulate hippocampal gyrus (OR: 0.99, 95% CI: 0.98-1.00, P = 0.003), orientation diffusion(OD) in the fornix and Stria terminalis (OR: 0.99, 95% CI: 0.98-1.00, P = 0.004) and isotropic volume fraction (ISOVF) (OR: 0.99, 95% CI: 0.99-1.00, P = 0.039) in the fornix, as well as an increase in OD in the posterior thalamic radiation (R) (OR: 0.99, 95% CI: 0.98-1.00, P = 0.047) reduce OA risk as protective factors. Increased subparietal lobule area (OR: 0.99, 95% CI: 0.98-1.00, P = 0.045) and middle temporal gyrus volume (OR: 0.98, 95% CI: 0.97-1.00, P = 0.029) also demonstrated a protective effect against OA. Conversely, OA risk was increased by increases in the medial thalamic tract's OD (OR: 1.01, 95% CI: 1.00-1.02, P = 0.034), the cerebral peduncle's intracellular volume fraction (ICVF) (OR: 1.01, 95% CI: 1.00-1.01, P = 0.010), the anterior limb of the internal capsule's ISOVF (OR: 1.01, 95% CI: 1.00-1.01, P = 0.033), and the posterior thalamic radiation(L) 's MO (OR: 1.02, 95% CI: 1.00-1.03, P = 0.024). Interestingly, lateral orbitofrontal volume decreased (R: OR: 0.99, 95% CI: 0.98-1.00, P = 0.013; L: OR: 0.99, 95% CI: 0.98-1.00, P = 0.038), while medial orbitofrontal increased risk (OR: 1.02, 95% CI: 1.00-1.04, P = 0.024).

Conclusion: Our findings provide genetic evidence for the prevention of OA based on the bone-brain axis and suggest a clinical strategy for integrated pain-psychomotor intervention through neural nociceptive modulation, limbic circuit stabilization, and motor pathway enhancement.

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绘制大脑在骨关节炎中的作用：预防的新证据。

目的：探讨脑结构参数与骨关节炎（OA）之间的因果关系，旨在预防OA进展。患者和方法：采用双样本孟德尔随机化。除样本量为484,598的欧洲OA数据外，还纳入同一来源的Firth校正OA数据和SPA校正OA数据作为结局数据。使用来自UK Biobank的3913个脑成像衍生表型（IDPs）作为暴露数据。加权中位数、MR Egger和IVW验证了因果关系。敏感性和异质性分析验证了研究结果的稳健性。结果：13个脑区与OA显著相关。扣带海马回分数各向异性（FA）的增加（OR: 0.99, 95% CI: 0.98-1.00, P = 0.003），穹窿和终纹的取向扩散（OD）（OR: 0.99, 95% CI: 0.98-1.00, P = 0.004）和各向同性体积分数（ISOVF）（OR: 0.99, 95% CI: 0.99-1.00, P = 0.039），以及丘脑后辐射(R)的OD增加（OR: 0.99, 95% CI: 0.98-1.00, P = 0.047）作为保护因素降低OA风险。增加的顶叶下小叶面积（OR: 0.99, 95% CI: 0.98-1.00, P = 0.045）和中颞回体积（OR: 0.98, 95% CI: 0.97-1.00, P = 0.029）也显示出对OA的保护作用。相反，丘脑内侧束的OD （OR: 1.01, 95% CI: 1.00-1.02, P = 0.034）、脑梗的细胞内体积分数（ICVF）（OR: 1.01, 95% CI: 1.00-1.01, P = 0.010）、内囊前肢的ISOVF （OR: 1.01, 95% CI: 1.00-1.01, P = 0.033）和丘脑后部辐射(L)的增加增加了OA的风险。（OR: 1.02, 95% CI: 1.00-1.03, P = 0.024）。有趣的是，侧眶额体积减小(R: OR: 0.99, 95% CI: 0.98-1.00, P = 0.013；L: OR: 0.99, 95% CI: 0.98-1.00, P = 0.038)，而内侧眶额部增加了风险（OR: 1.02, 95% CI: 1.00-1.04, P = 0.024）。结论：我们的研究结果为骨脑轴预防骨性关节炎提供了遗传证据，并提出了通过神经伤害性调节、边缘回路稳定和运动通路增强进行疼痛-精神运动综合干预的临床策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Multidisciplinary Healthcare Nursing-General Nursing

CiteScore

4.60

自引率

3.00%

发文量

287

审稿时长

16 weeks

期刊介绍： The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.