美国成年人甘油三酯-葡萄糖指数及其联合肥胖指标和肾结石之间的关系

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-09-30 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S552357
Xinyu Hu, Linqun Wang, Shuqi Min, Xialin Tang, Bowen Lu, Mingyan Lei, Shiyan Shang, Zhihui Yang, Qiwang He
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引用次数: 0

摘要

目的:甘油三酯-葡萄糖(TyG)指数及TyG联合肥胖指标[TyG-腰围(TyG- wc)、TyG-腰高比(TyG- whtr)、TyG-体重指数(TyG- bmi)]与肾结石(KS)的关系在美国研究较少。这项研究的目的是在全国范围内大量人群中检验这些关系。方法:本横断面研究共招募了2007-2018年国家健康与营养检查调查(NHANES)的9808名成人参与者。为了研究TyG指数、TyG- wc、TyG- whtr和TyG- bmi与KS的关系,采用了多变量logistic回归、限制三次样条(RCS)、中介分析、敏感性分析、亚组分析和交互作用分析。结果:本分析显示,TyG联合肥胖指标[TyG- wc,(比值比(OR) = 2.19, 95% CI: 1.69 ~ 2.84, P < 0.001);TyG-WHtR (OR = 2.26, 95% CI: 1.73—-2.95,P < 0.001);与单独的TyG指数相比,TyG- bmi (OR = 1.88, 95% CI: 1.48-2.39, P < 0.001)与KS的相关性更强(OR = 1.40, 95% CI: 1.10-1.78, P = 0.006)。RCS分析显示,TyG指数及TyG联合肥胖指标与KS呈线性相关(P-overall < 0.0001, P-nonlinear > 0.05)。中介分析表明,高密度脂蛋白胆固醇(HDL-C)具有显著的中介作用。结论:本研究中,TyG指数及TyG联合肥胖指标(TyG- wc、TyG- whtr、TyG- bmi)与KS呈显著正相关。此外,与单独的TyG指数相比,TyG与肥胖指标联合显示出更强的诊断相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Between the Triglyceride-Glucose Index Along with Its Combinations with Obesity Indicators and Kidney Stone Among American Adults.

Objective: Relationships of triglyceride-glucose (TyG) index and TyG combined with obesity indicators [TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI)] with kidney stone (KS) have been infrequently investigated among the American. This study aimed to examine these relationships within a substantial, nationwide population.

Methods: The current cross-sectional study recruited totally 9,808 adult participants in National Health and Nutrition Examination Survey (NHANES) 2007-2018. For investigating relations of the TyG index, TyG-WC, TyG-WHtR, and TyG-BMI with KS, multivariate logistic regression, restricted cubic spline (RCS), mediation, sensitivity, subgroup and interaction analyses were used.

Results: This analysis indicated that TyG combined with obesity indicators [TyG-WC, (odds ratio (OR) = 2.19, 95% CI: 1.69-2.84, P < 0.001); TyG-WHtR, (OR = 2.26, 95% CI: 1.73-2.95, P < 0.001); TyG-BMI, (OR = 1.88, 95% CI: 1.48-2.39, P < 0.001)] exhibited a stronger correlation with KS compared to the TyG index alone (OR = 1.40, 95% CI: 1.10-1.78, P = 0.006). Based on RCS analysis, TyG index and TyG combined with obesity indicators were linearly related to KS (P-overall < 0.0001, P-nonlinear > 0.05). Mediation analysis indicated that high-density lipoprotein cholesterol (HDL-C) had a significant mediating effect.

Conclusion: In this study, TyG index and TyG combined with obesity indicators (TyG-WC, TyG-WHtR and TyG-BMI) show a significantly positive relationship to KS. Furthermore, in comparison to the TyG index alone, TyG combined with obesity indicators exhibited enhanced diagnostic relevance.

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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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