{"title":"Associations Between the Triglyceride-Glucose Index Along with Its Combinations with Obesity Indicators and Kidney Stone Among American Adults.","authors":"Xinyu Hu, Linqun Wang, Shuqi Min, Xialin Tang, Bowen Lu, Mingyan Lei, Shiyan Shang, Zhihui Yang, Qiwang He","doi":"10.2147/JMDH.S552357","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Relationships of triglyceride-glucose (TyG) index and TyG combined with obesity indicators [TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI)] with kidney stone (KS) have been infrequently investigated among the American. This study aimed to examine these relationships within a substantial, nationwide population.</p><p><strong>Methods: </strong>The current cross-sectional study recruited totally 9,808 adult participants in National Health and Nutrition Examination Survey (NHANES) 2007-2018. For investigating relations of the TyG index, TyG-WC, TyG-WHtR, and TyG-BMI with KS, multivariate logistic regression, restricted cubic spline (RCS), mediation, sensitivity, subgroup and interaction analyses were used.</p><p><strong>Results: </strong>This analysis indicated that TyG combined with obesity indicators [TyG-WC, (odds ratio (OR) = 2.19, 95% CI: 1.69-2.84, <i>P</i> < 0.001); TyG-WHtR, (OR = 2.26, 95% CI: 1.73-2.95, <i>P</i> < 0.001); TyG-BMI, (OR = 1.88, 95% CI: 1.48-2.39, <i>P</i> < 0.001)] exhibited a stronger correlation with KS compared to the TyG index alone (OR = 1.40, 95% CI: 1.10-1.78, <i>P</i> = 0.006). Based on RCS analysis, TyG index and TyG combined with obesity indicators were linearly related to KS (<i>P</i>-overall < 0.0001, <i>P</i>-nonlinear > 0.05). Mediation analysis indicated that high-density lipoprotein cholesterol (HDL-C) had a significant mediating effect.</p><p><strong>Conclusion: </strong>In this study, TyG index and TyG combined with obesity indicators (TyG-WC, TyG-WHtR and TyG-BMI) show a significantly positive relationship to KS. Furthermore, in comparison to the TyG index alone, TyG combined with obesity indicators exhibited enhanced diagnostic relevance.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"6233-6244"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495975/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S552357","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Relationships of triglyceride-glucose (TyG) index and TyG combined with obesity indicators [TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI)] with kidney stone (KS) have been infrequently investigated among the American. This study aimed to examine these relationships within a substantial, nationwide population.
Methods: The current cross-sectional study recruited totally 9,808 adult participants in National Health and Nutrition Examination Survey (NHANES) 2007-2018. For investigating relations of the TyG index, TyG-WC, TyG-WHtR, and TyG-BMI with KS, multivariate logistic regression, restricted cubic spline (RCS), mediation, sensitivity, subgroup and interaction analyses were used.
Results: This analysis indicated that TyG combined with obesity indicators [TyG-WC, (odds ratio (OR) = 2.19, 95% CI: 1.69-2.84, P < 0.001); TyG-WHtR, (OR = 2.26, 95% CI: 1.73-2.95, P < 0.001); TyG-BMI, (OR = 1.88, 95% CI: 1.48-2.39, P < 0.001)] exhibited a stronger correlation with KS compared to the TyG index alone (OR = 1.40, 95% CI: 1.10-1.78, P = 0.006). Based on RCS analysis, TyG index and TyG combined with obesity indicators were linearly related to KS (P-overall < 0.0001, P-nonlinear > 0.05). Mediation analysis indicated that high-density lipoprotein cholesterol (HDL-C) had a significant mediating effect.
Conclusion: In this study, TyG index and TyG combined with obesity indicators (TyG-WC, TyG-WHtR and TyG-BMI) show a significantly positive relationship to KS. Furthermore, in comparison to the TyG index alone, TyG combined with obesity indicators exhibited enhanced diagnostic relevance.
期刊介绍:
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.