Adipose-Derived Stem Cells for Cartilage Tissue Engineering: A Bibliometric Analysis of Trends and Themes.

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S522203
Jing Zhang, Kai Wu, Lin Zhou, Shusen Zheng
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引用次数: 0

Abstract

Purpose: Adipose-derived stem cells (ADSCs) have shown great potential in cartilage tissue engineering (TE) due to their accessibility, high proliferation rate, and chondrogenic differentiation capacity. This study aims to systematically evaluate research trends, collaboration patterns, and emerging themes in ADSC-based cartilage TE through a bibliometric analysis, providing actionable insights to address knowledge gaps and advance the field.

Patients and methods: A systematic search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to ADSCs and cartilage TE. Bibliometric and visualized analysis was performed using VOSviewers (V 1.6.20), CiteSpace (V 6.3.R1) and Bibliometrix (R 4.3.3).

Results: A total of 436 English articles were analyzed, involving 2356 authors from 1532 institutions across 50 countries/regions, contributing to 189 journals. The annual growth rate of publications was 8.73%, peaking in 2021. China contributed the most articles (n=127, 29.1%), followed by the USA (n=65, 14.9%). Leading institutions included Kaohsiung Medical University and Duke University. Tissue Engineering Part A had the highest H-index (21) and the most publications (n = 26). Reis Rui L. and Gomes Manuela E. were among the most influential contributors. Keyword analysis revealed an early focus on "in-vitro" studies and "bone-marrow", which later transitioned to "chondrogenic differentiation", "growth", and "regeneration". Recent trends since 2020 include "3D printing", "mesenchymal stem cells", and "cartilage repair", reflecting the field's evolution towards advanced technologies and translational applications.

Conclusion: This bibliometric analysis provides valuable guidance for researchers, clinicians, and policymakers, emphasizing the necessity of addressing translational challenges and fostering global collaboration to develop clinically effective solutions for cartilage repair and regeneration.

脂肪来源干细胞用于软骨组织工程:趋势和主题的文献计量学分析。
目的:脂肪源性干细胞(ADSCs)因其可及性、高增殖率和成软骨分化能力在软骨组织工程(TE)中显示出巨大的潜力。本研究旨在通过文献计量分析系统地评估基于adsc的软骨TE的研究趋势、合作模式和新兴主题,为解决知识差距和推进该领域提供可操作的见解。患者和方法:在Web of Science Core Collection (WoSCC)数据库中进行系统搜索,以确定与ADSCs和软骨TE相关的出版物。使用vosviewer (v1.6.20)、CiteSpace (v6.3 . r1)和Bibliometrix (v4.3.3)进行文献计量和可视化分析。结果:共分析英文论文436篇,涉及50个国家/地区1532家机构的2356位作者,投稿期刊189个。出版物年增长率为8.73%,在2021年达到峰值。中国贡献的文章最多(n=127, 29.1%),其次是美国(n=65, 14.9%)。主要机构包括高雄医科大学和杜克大学。组织工程A部分h指数最高(21),发表文献最多(n = 26)。Reis Rui L.和Gomes Manuela E.是最有影响力的贡献者。关键词分析显示,早期的重点是“体外”研究和“骨髓”,后来转变为“软骨分化”、“生长”和“再生”。自2020年以来的最新趋势包括“3D打印”、“间充质干细胞”和“软骨修复”,反映了该领域向先进技术和转化应用的发展。结论:该文献计量分析为研究人员、临床医生和政策制定者提供了有价值的指导,强调了解决转化挑战和促进全球合作的必要性,以开发临床有效的软骨修复和再生解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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