Journal of Materials Chemistry最新文献_第5页

Immobilization of magnetic iron oxide nanoparticles on laponite discs - an easy way to biocompatible ferrofluids and ferrogels. 磁性氧化铁纳米颗粒在拉脱土圆盘上的固定化-一种生物相容性铁磁流体和铁凝胶的简单方法。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/c0jm00061b

Vassilios Tzitzios, Georgia Basina, Aristides Bakandritsos, Costas G Hadjipanayis, Hui Mao, Dimitrios Niarchos, George C Hadjipanayis, Jiri Tucek, Radek Zboril

{"title":"Immobilization of magnetic iron oxide nanoparticles on laponite discs - an easy way to biocompatible ferrofluids and ferrogels.","authors":"Vassilios Tzitzios, Georgia Basina, Aristides Bakandritsos, Costas G Hadjipanayis, Hui Mao, Dimitrios Niarchos, George C Hadjipanayis, Jiri Tucek, Radek Zboril","doi":"10.1039/c0jm00061b","DOIUrl":"https://doi.org/10.1039/c0jm00061b","url":null,"abstract":"Magnetic nanocomposites containing iron oxide (maghemite) nanoparticles, well embedded in a synthetic clay matrix (laponite) were prepared by a new one step chemical route and characterized by TEM, XRD, magnetization measurements, Mössbauer spectroscopy, DLS, and MRI measurements. The synthetic procedure leads to non-stoichiometric γ-Fe(2)O(3) with a controllable content in the nanocomposite. Magnetic nanoparticles incorporated in the diamagnetic clay matrix exhibit a mean diameter of 13 nm, superparamagnetic behavior with a high saturation magnetization achievable at low applied magnetic fields. In-field Mössbauer spectra and ZFC/FC magnetization curves reveal a perfect ferrimagnetic ordering within nanoparticles with negligible spin frustration and interparticle interactions due to the complete coating of maghemite surfaces by the nanocrystalline laponite matrix. Magnetic iron oxide nanoparticles embedded in laponite matrix exhibit strong T(2) weighted MRI contrast. The maghemite/laponite composite particles have 200 nm hydrodynamic diameter and form very stable hydrosols and/or hydrogels depending on their concentration in water.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/c0jm00061b","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29082217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Functionalization of iron oxide nanoparticles with a versatile epoxy amine linker. 氧化铁纳米颗粒与多功能环氧胺连接剂的功能化。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/c0jm00808g

Michael Nickels, Jingping Xie, Jared Cobb, John C Gore, Wellington Pham

{"title":"Functionalization of iron oxide nanoparticles with a versatile epoxy amine linker.","authors":"Michael Nickels, Jingping Xie, Jared Cobb, John C Gore, Wellington Pham","doi":"10.1039/c0jm00808g","DOIUrl":"https://doi.org/10.1039/c0jm00808g","url":null,"abstract":"A synthetically diverse linker molecule consisting of both a terminal epoxide and a terminal amine has been synthesized and shown to have the desired reactivity. Proof of principle experimentation showed that the prepared linker molecule possessed the ability to be reactive towards dextran coated iron nanoparticles, essentially converting the surface alcohols to amines with an efficiency on average of 50 linkers per nanoparticle. Once the surface of the nanoparticles had been functionalized, the iron nanoparticles were subsequently functionalized with both folic acid and fluorescein isothiocyanate, with an average efficiency of 20 and 3 molecules per nanoparticle, respectively. The labeled nanoparticles were then incubated with both folate receptor positive and negative cell lines, which showed a preferential accumulation of the particles in the receptor positive cell line. In addition to the fluorescence based assays, accumulation of the nanoparticles was demonstrated using T2-weighted MRI imaging, which showed that the iron core of the nanoparticle was present within the desired cell line. Overall, this linker has shown the ability to functionalize the surface of nanoparticles and can theoretically be used to label a wide variety of other targeting agents or imaging agents for in vivo therapies or diagnostics.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/c0jm00808g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29156827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Synthesis and characterization of highly photoresponsive fullerenyl dyads with a close chromophore antenna-C(60) contact and effective photodynamic potential. 具有密切的发色团天线- c(60)接触和有效光动力势的高光响应的富勒烯基二偶体的合成和表征。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/C0JM00037J

Long Y Chiang, Prashant A Padmawar, Joy E Rogers-Haley, Grace So, Taizoon Canteenwala, Sammaiah Thota, Loon-Seng Tan, Kenneth Pritzker, Ying-Ying Huang, Sulbha K Sharma, Divya Balachandran Kurup, Michael R Hamblin, Brian Wilson, Augustine Urbas

{"title":"Synthesis and characterization of highly photoresponsive fullerenyl dyads with a close chromophore antenna-C(60) contact and effective photodynamic potential.","authors":"Long Y Chiang, Prashant A Padmawar, Joy E Rogers-Haley, Grace So, Taizoon Canteenwala, Sammaiah Thota, Loon-Seng Tan, Kenneth Pritzker, Ying-Ying Huang, Sulbha K Sharma, Divya Balachandran Kurup, Michael R Hamblin, Brian Wilson, Augustine Urbas","doi":"10.1039/C0JM00037J","DOIUrl":"https://doi.org/10.1039/C0JM00037J","url":null,"abstract":"We report the synthesis of a new class of photoresponsive C(60)-DCE-diphenylaminofluorene nanostructures and their intramolecular photoinduced energy and electron transfer phenomena. Structural modification was made by chemical conversion of the keto group in C(60)(>DPAF-C(n)) to a stronger electron-withdrawing 1,1-dicyanoethylenyl (DCE) unit leading to C(60)(>CPAF-C(n)) with an increased electronic polarization of the molecule. The modification also led to a large bathochromic shift of the major band in visible spectrum giving measureable absorption up to 600 nm and extended the photoresponsive capability of C(60)-DCE-DPAF nanostructures to longer red wavelengths than C(60)(>DPAF-C(n)). Accordingly, C(60)(>CPAF-C(n)) may allow 2γ-PDT using a light wavelength of 1000-1200 nm for enhanced tissue penetration depth. Production efficiency of singlet oxygen by closely related C(60)(>DPAF-C(2) (M)) was found to be comparable with that of tetraphenylporphyrin photosensitizer. Remarkably, the (1)O(2) quantum yield of C(60)(>CPAF-C(2) (M)) was found to be nearly 6-fold higher than that of C(60)(>DPAF-C(2) (M)), demonstrating the large light-harvesting enhancement of the CPAF-C(2) (M) moiety and leading to more efficient triplet state generation of the C(60)> cage moiety. This led to highly effective killing of HeLa cells by C(60)(>CPAF-C(2) (M)) via photodynamic therapy (200 J cm(-2) white light). We interpret the phenomena in terms of the contributions by the extended π-conjugation and stronger electron-withdrawing capability associated with the 1,1-dicyanoethylenyl group compared to that of the keto group.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/C0JM00037J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29329792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Tailored Synthesis of Nitric Oxide-Releasing Polyurethanes Using O-Protected Diazeniumdiolated Chain Extenders. 使用 O 型保护重氮二醇链延伸剂定制合成释放一氧化氮的聚氨酯。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/c000152j

Melissa M Reynolds, Joseph E Saavedra, Brett M Showalter, Carlos A Valdez, Anna P Shanklin, Bong K Oh, Larry K Keefer, Mark E Meyerhoff

{"title":"Tailored Synthesis of Nitric Oxide-Releasing Polyurethanes Using O-Protected Diazeniumdiolated Chain Extenders.","authors":"Melissa M Reynolds, Joseph E Saavedra, Brett M Showalter, Carlos A Valdez, Anna P Shanklin, Bong K Oh, Larry K Keefer, Mark E Meyerhoff","doi":"10.1039/c000152j","DOIUrl":"10.1039/c000152j","url":null,"abstract":"Nitric oxide (NO) has been shown to exhibit significant anti-platelet activity and its release from polymer matrices has been already utilized to increase the biocompatibility of various blood-contacting devices. Herein, details of a new synthetic approach for preparing NO-releasing diazeniumdiolated polyurethanes (PU) are described. The method's utility is demonstrated by the incorporation of methoxymethyl- or sugar-protected pre-formed diazeniumdiolate moieties directly into chain extender diols which are then incorporated into the polyurethane backbone. This approach provides the ability to control the number of diazeniumdiolate groups incorporated into the polymer backbone, and hence the surface flux of NO that can ultimately be liberated from polymeric films prepared from the new PU materials. The method provides a means of covalently attaching diazeniumdiolate groups to polyurethanes in a form that resists dissociation of NO during processing but can be activated for spontaneous NO release via hydrolysis of the carbohydrate or methoxymethyl moieties under basic and acidic conditions, respectively.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994584/pdf/nihms250673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29513091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Tunable Rainbow Colored Colloidal Silver Nanoparticles Using Single-Nanoparticle Plasmonic Microscopy and Spectroscopy. 利用单纳米粒子等离子体显微镜和光谱学合成和表征可调谐彩虹色胶体银纳米粒子。

Journal of Materials Chemistry Pub Date : 2010-01-01 Epub Date: 2010-09-30 DOI: 10.1039/C0JM01990A

Tao Huang, Xiao-Hong Nancy Xu

{"title":"Synthesis and Characterization of Tunable Rainbow Colored Colloidal Silver Nanoparticles Using Single-Nanoparticle Plasmonic Microscopy and Spectroscopy.","authors":"Tao Huang, Xiao-Hong Nancy Xu","doi":"10.1039/C0JM01990A","DOIUrl":"https://doi.org/10.1039/C0JM01990A","url":null,"abstract":"Noble metal nanoparticles (NPs) possess size- and shape- dependent optical properties, suggesting the possibility of tuning desired optical properties of ensemble NPs at single NP resolution and underscoring the importance of probing the sizes and shapes of single NPs in situ and in real-time. In this study, we synthesized twelve colloids of Ag NPs. Each colloid contains various sizes and shapes of single NPs, showing rainbow colors with peak-wavelength of absorption spectra from 393 to 738 nm. We correlated the sizes and shapes of single NPs determined by high-resolution transmission electron microscopy (HRTEM) with scattering localized surface plasmon resonance (LSPR) spectra of single NPs characterized by dark-field optical microcopy and spectroscopy (DFOMS). Single spherical (2-39 nm in diameter), rod (2-47 nm in length with aspect ratios of 1.3-1.6), and triangular (4-84 nm in length with thickness of 2-27 nm) NPs show LSPR spectra (λ(max)) at 476±5 or 533±12, 611±23, and 711±40 nm, respectively. Notably, we observed new cookie-shaped NPs, which exhibit LSPR spectra (λ(max)) at 725±10 nm with a shoulder peak at 604±5 nm. Linear correlations of sizes of any given shape of single NPs with their LSPR spectra (λ(max)) enable the creation of nano optical rulers (calibration curves) for identification of the sizes and shapes of single NPs in solution in real time using DFOMS, offering the feasibility of using single NPs as multicolored optical probes for study of dynamics events of interest in solutions and living organisms at nm scale in real time.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/C0JM01990A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30698432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 228

Photocatalytic Properties of Porous Silicon Nanowires. 多孔硅纳米线的光催化性能。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/c0jm00493f

Yongquan Qu, Xing Zhong, Yujing Li, Lei Liao, Yu Huang, Xiangfeng Duan

引用次数: 116

Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancer. 金纳米共轭物的制备和功能表征，有望应用于卵巢癌的治疗。

Journal of Materials Chemistry Pub Date : 2010-01-01 DOI: 10.1039/b913224d

Chitta Ranjan Patra, Resham Bhattacharya, Priyabrata Mukherjee

{"title":"Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancer.","authors":"Chitta Ranjan Patra, Resham Bhattacharya, Priyabrata Mukherjee","doi":"10.1039/b913224d","DOIUrl":"10.1039/b913224d","url":null,"abstract":"In this paper we report the surface modification and functional characterization of a gold nanoparticle-based drug delivery system for potential therapeutic application in ovarian cancer. It is currently recognized that nanotechnology may play a pivotal role in drug delivery by increasing efficacy and reducing toxicity of anti-cancer drugs. Here, we report the fabrication of a gold nanoparticles (AuNP) based drug delivery system consisting of folic acid (FA), mercapto-polyethylene glycol (PEG-SH) with a molecular weight of 2000 (designated as PSH2-2K or PSH) and cis-platin (CP) [Au-PSH-CP-FA] for potential therapeutic application in ovarian cancer. Fabrication is done in a three steps incubation process at room temperature (RT). The gold nanoconjugates are characterized with several physico-chemical techniques such as UV-Vis (UV-Visible spectroscopy), TEM (Transmission electron microscopy), ICP (Inductively coupled plasma) and radioactivity measurement with a scintillation counter. Attachment and release profiles of FA from the gold nanoconjugates are performed using (3)H-labelled FA ((3)H-FA). The expressions of folate receptor (FR) for ovarian cancer cell lines (OV-167, OVCAR-5), human umbilical vein endothelial cells (HUVEC) and ovarian surface epithelial (OSE) cells are determined by FACS analysis. Quantitation of platinum content in the nanoconjugates and its release profile is determined by platinum (Pt) analysis using ICP-MS. Biological functional characterization using in vitro proliferation assay demonstrates that Au-PSH-CP-FA not only retains the cytotoxic effect of CP, but it protects the normal cells from the cytotoxic insult, while enhancing the cytotoxic effect on the tumor cells. In future, this strategy may be utilized as a strategy for the treatment of ovarian cancers and may overcome the core side effect issues in anticancer therapy.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860188/pdf/nihms-194858.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28960677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A photochemically initiated chemistry for coupling underivatized carbohydrates to gold nanoparticles. 将未充分活化的碳水化合物与金纳米颗粒耦合的光化学引发化学反应。

Journal of Materials Chemistry Pub Date : 2009-12-21 DOI: 10.1039/B917900C

Xin Wang, Olof Ramström, Mingdi Yan

{"title":"A photochemically initiated chemistry for coupling underivatized carbohydrates to gold nanoparticles.","authors":"Xin Wang, Olof Ramström, Mingdi Yan","doi":"10.1039/B917900C","DOIUrl":"10.1039/B917900C","url":null,"abstract":"The sensitive optoelectronic properties of metal nanoparticles make nanoparticle-based materials a powerful tool to study fundamental biorecognition processes. Here we present a new and versatile method for coupling underivatized carbohydrates to gold nanoparticles (Au NPs) via the photochemically induced reaction of perfluorophenylazide (PFPA). A one-pot procedure was developed where Au NPs were synthesized and functionalized with PFPA by a ligand-exchange reaction. Carbohydrates were subsequently immobilized on the NPs by a fast light activation. The coupling reaction was efficient, resulting in high coupling yield as well as high ligand surface coverage. A colorimetric system based on the carbohydrate-modified Au NPs was used for the sensitive detection of carbohydrate-protein interactions. Binding and cross-reactivity studies were carried out between carbohydrate-functionalized Au NPs and lectins. Results showed that the surface-bound carbohydrates not only retained their binding affinities towards the corresponding lectin, but also exhibited affinity ranking consistent with that of the free ligands in solution.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941222/pdf/nihms174271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40082261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery. 纳米粒子技术：解决蛋白质生物标记物发现的基本障碍。

Journal of Materials Chemistry Pub Date : 2009-08-07 DOI: 10.1039/b822264a

Alessandra Luchini, Caterina Longo, Virginia Espina, Emanuel F Petricoin, Lance A Liotta

引用次数: 0

Biomedical applications of chemically-modified silk fibroin. 化学改性丝素蛋白的生物医学应用。

Journal of Materials Chemistry Pub Date : 2009-06-23 DOI: 10.1039/b905802h

Amanda R Murphy, David L Kaplan

引用次数: 383