Journal of Materials Chemistry最新文献_第6页

Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles. 来自茶叶的绿色纳米技术:茶叶中的植物化学物质作为生产生物相容性金纳米颗粒的基石。

Journal of Materials Chemistry Pub Date : 2009-06-01 DOI: 10.1039/b822015h

Satish K Nune, Nripen Chanda, Ravi Shukla, Kavita Katti, Rajesh R Kulkarni, Subramanian Thilakavathi, Swapna Mekapothula, Raghuraman Kannan, Kattesh V Katti

{"title":"Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles.","authors":"Satish K Nune, Nripen Chanda, Ravi Shukla, Kavita Katti, Rajesh R Kulkarni, Subramanian Thilakavathi, Swapna Mekapothula, Raghuraman Kannan, Kattesh V Katti","doi":"10.1039/b822015h","DOIUrl":"https://doi.org/10.1039/b822015h","url":null,"abstract":"Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve the dual roles as effective reducing agents to reduce gold and also as stabilizers to provide robust coating on the gold nanoparticles in a single step. The Tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and have been found to be non toxic as assessed through MTT assays. No 'man made' chemicals, other than gold salts, are used in this true biogenic green nanotechnological process thus paving excellent opportunities for their applications in molecular imaging and therapy.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/b822015h","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28718295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 351

Pharmaceutical organogels prepared from aromatic amino acid derivatives. 用芳香族氨基酸衍生物制备药用有机凝胶。

Journal of Materials Chemistry Pub Date : 2009-04-28 DOI: 10.1039/B822657A

Guillaume Bastiat, Jean-Christophe Leroux

{"title":"Pharmaceutical organogels prepared from aromatic amino acid derivatives.","authors":"Guillaume Bastiat, Jean-Christophe Leroux","doi":"10.1039/B822657A","DOIUrl":"10.1039/B822657A","url":null,"abstract":"Organogels are semi-solid systems in which an organic liquid phase is immobilized by a 3-dimensional network composed of self-assembled gelator molecules. Although there is a large variety of organogel systems, relatively few have been investigated in the field of drug delivery, owing mostly to the lack of information on their biocompatibility and toxicity. In this work, organogelator-biocompatible structures based on aromatic amino acids, namely, tyrosine, tryptophan, and phenylalanine were synthesized by derivatization with aliphatic chains. Their ability to gel an injectable vegetable oil (i.e. safflower oil) and to sustain the release of a model anti-Alzheimer drug (i.e. rivastigmine) was then evaluated. Organogels and molecular packing were characterized by differential scanning calorimetry, rheology analysis, Fourier-transform infrared spectroscopy and X-ray crystallography. The amino acid derivatives were able to gel safflower oil through van der Waals interactions and H-bonds. Tyrosine-derivatives produced the strongest gels while tryptophan was associated with poor gelling properties. The superior gelling ability of tyrosine derivatives could be explained by their well-structured 2-dimensional packing in the network. The addition of an optimal N-methyl-2-pyrrolidone amount to tyrosine gels fluidized the network and allowed their injection through conventional needles. Upon contact with an aqueous medium, the gels formed in situ and released entrapped rivastigmine in a sustained fashion.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835228/pdf/nihms5148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34479094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and In vitro activity of ROMP-based polymer nanoparticles. romp基纳米聚合物的合成及体外活性研究。

Journal of Materials Chemistry Pub Date : 2009-04-21 DOI: 10.1039/B817511J

Deedee Smith, Sandra H Clark, Paul A Bertin, Bernard L Mirkin, Sonbinh T Nguyen

{"title":"Synthesis and In vitro activity of ROMP-based polymer nanoparticles.","authors":"Deedee Smith, Sandra H Clark, Paul A Bertin, Bernard L Mirkin, Sonbinh T Nguyen","doi":"10.1039/B817511J","DOIUrl":"https://doi.org/10.1039/B817511J","url":null,"abstract":"A new type of polymer nanoparticle (PNP) containing a high density of covalently linked doxorubicin, attached via a non-cleavable amine linkage (amine-linked Dox-PNP) was prepared. Together with a previously reported cleavable carbamate-linked Dox-PNP, this new amine-linked Dox-PNP was subsequently evaluated against free doxorubicin for its cytotoxicity and inhibitory effects on SKNSH wild-type and SKrDOX6 doxorubicin-resistant human neuroblastoma cell lines. Analogous cholesterol-containing PNPs (Chol-PNPs) and indomethacin-containing PNPs (IND-PNPs) were also synthesized and used as the non-cytotoxic controls. While neither cell line was affected by Chol-PNPs or IND-PNPs, SKrDOX6 doxorubicin-resistant cells exhibited similar cytotoxic responses to free doxorubicin and both amine- and carbamate-linked Dox-PNPs, suggesting that doxorubicin or the doxorubicin-containing polymer must be the active agent in the latter case. SKNSH wild-type cells also responded to both Dox-PNPs, albeit at a higher apparent concentration than free doxorubicin alone. The growth of SKNSH wild-type cells was significantly inhibited upon incubation with carbamate-linked Dox-PNPs, as with free doxorubicin, over a 7-day period. In comparison to free doxorubicin, carbamate-linked Dox-PNPs produced a longer (72-h) period of initial inhibition in SKrDOX6 doxorubicin-resistant cells.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/B817511J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32026003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Functional DNA directed assembly of nanomaterials for biosensing. 用于生物传感的功能性 DNA 定向组装纳米材料。

Journal of Materials Chemistry Pub Date : 2009-04-07 DOI: 10.1039/B813939C

Zidong Wang, Yi Lu

{"title":"Functional DNA directed assembly of nanomaterials for biosensing.","authors":"Zidong Wang, Yi Lu","doi":"10.1039/B813939C","DOIUrl":"10.1039/B813939C","url":null,"abstract":"This review summarizes recent progress in the development of biosensors by integrating functional DNA molecules with different types of nanomaterials, including metallic nanoparticles, semiconductor nanoparticles, magnetic nanoparticles, and carbon nanotubes. On one hand, advances in nanoscale science and technology have generated nanomaterials with unique optical, electrical, magnetic and catalytic properties. On the other hand, recent progress in biology has resulted in functional DNAs, a new class of DNAs that can either bind to a target molecule (known as aptamers) or perform catalytic reactions (known as DNAzymes) with the ability to recognize a broad range of targets from metal ions to organic molecules, proteins and cells specifically. By taking advantage of the strengths in both fields, the physical and chemical properties of nanomaterials have been modulated by the target recognition and catalytic activity of functional DNAs in the presence of a target analyte, resulting in a large number of colorimetric, fluorescent, electrochemical, surface-enhanced Raman scattering and magnetic resonance imaging sensors for the detection of a broad range of analytes with high sensitivity and selectivity.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846351/pdf/nihms505587.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31929195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of quantum dot-polymer composites. 量子点-聚合物复合材料的合成与表征。

Journal of Materials Chemistry Pub Date : 2009-04-01 DOI: 10.1039/b820204d

Joe Weaver, Rashid Zakeri, Samir Aouadi, Punit Kohli

{"title":"Synthesis and characterization of quantum dot-polymer composites.","authors":"Joe Weaver, Rashid Zakeri, Samir Aouadi, Punit Kohli","doi":"10.1039/b820204d","DOIUrl":"https://doi.org/10.1039/b820204d","url":null,"abstract":"In this study, we demonstrate a facile and simple synthesis of quantum dot (QD)-polymer composites. Highly fluorescent semiconducting CdSe/ZnS quantum dots were embedded in different commercially available polymers using one easy step. QD-polymer composite nanoparticles were also synthesized using template-assisted synthesis. In particular, we self-assembled lamellar micelles inside nanoporous alumina membranes which were used for the synthesis of mesoporous silica hollow nanotubes and solid nanorods. We observed that the addition of excess free octadecylamine (ODA) in the QD-silica solution resulted in gelation. The gelation time was found to be dependent on free ODA concentration. Similarly, the emission of QD-polymer composites was also found to be dependent on free ODA concentration. Highly purified QDs provided polymer composites that have a much lower emission compared to unpurified nanocomposites. This was attributed to passivation of the QD surfaces by amine, which reduced the surface defects and non-radiative pathways for excited QDs. Finally, highly fluorescent QD-polymer patterns were demonstrated on glass substrates which retained their emission in both polar and non-polar solvents.","PeriodicalId":16297,"journal":{"name":"Journal of Materials Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/b820204d","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28527093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Silica nanoparticles as a delivery system for nucleic acid-based reagents. 二氧化硅纳米颗粒作为核酸基试剂的递送系统。

Journal of Materials Chemistry Pub Date : 2009-01-01 DOI: 10.1039/b904197d

Christopher Hom, Jie Lu, Fuyuhiko Tamanoi

引用次数: 69

A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging. 一种用于肺癌成像的超顺磁性氧化铁纳米颗粒表面修饰的新策略。

Journal of Materials Chemistry Pub Date : 2009-01-01 DOI: 10.1039/b902358e

Gang Huang, Chunfu Zhang, Shunzi Li, Chalermchai Khemtong, Su-Geun Yang, Ruhai Tian, John D Minna, Kathlynn C Brown, Jinming Gao

引用次数: 82

Multifunctional Nanoparticles as Biocompatible Targeted Probes for Human Cancer Diagnosis and Therapy. 多功能纳米颗粒作为人类癌症诊断和治疗的生物相容性靶向探针。

Journal of Materials Chemistry Pub Date : 2009-01-01 DOI: 10.1039/b817667c

Ken-Tye Yong, Indrajit Roy, Mark T Swihart, Paras N Prasad