Alessandra Luchini, Caterina Longo, Virginia Espina, Emanuel F Petricoin, Lance A Liotta
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Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery.
The incorporation of affinity baits into N-isopropylacrylamide-hydrogel-based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.
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