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Natural history and clinical manifestation of Pediatric Brain Arteriovenous Malformations. 小儿脑动静脉畸形的自然史和临床表现。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 DOI: 10.3340/jkns.2024.0037
Adikarige Haritha Dulanka Silva, Greg James
{"title":"Natural history and clinical manifestation of Pediatric Brain Arteriovenous Malformations.","authors":"Adikarige Haritha Dulanka Silva, Greg James","doi":"10.3340/jkns.2024.0037","DOIUrl":"10.3340/jkns.2024.0037","url":null,"abstract":"<p><p>Brain arteriovenous malformations (bAVMs) are aberrant arteriovenous shunts through a vascular nidus with no intervening capillary beds. They are one of the commonest causes of spontaneous intracranial haemorrhage in children and may be associated with significant morbidity and mortality in cases of rupture. Treatment strategies include microsurgical resection, endovascular embolisation, stereotactic radiosurgery, multimodality treatment with a combination thereof, and particularly in high-grade bAVMs, conservative management. Clinicians involved in treating bAVMs need to have familiarity with the natural history pertaining to bAVMs in terms of risk of rupture, risk factors elevating rupture risk as well as understanding the clinical manifestations of bAVMs. This invited review serves to provide a synthesis on natural history and clinical presentation of bAVMs with particular focus in children to inform decision-making pertaining to management.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface : Invited Issue Editor, Professor Edward R. Smith, and the Pediatric Vascular Malformations of the Central Nervous System. 前言：本期特邀编辑 Edward R. Smith 教授和儿科中枢神经系统血管畸形。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 Epub Date: 2024-03-05 DOI: 10.3340/jkns.2024.0048
Jun Bum Park, Seung-Ki Kim
{"title":"Preface : Invited Issue Editor, Professor Edward R. Smith, and the Pediatric Vascular Malformations of the Central Nervous System.","authors":"Jun Bum Park, Seung-Ki Kim","doi":"10.3340/jkns.2024.0048","DOIUrl":"10.3340/jkns.2024.0048","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Central Nervous System Vascular Malformation : Pathological Review with Diagram. 小儿中枢神经系统血管畸形：病理回顾与图解》（Pediatric Central Nervous System Vascular Malformation : Pathological Review with Diagram.
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.3340/jkns.2024.0006
Se Hoon Kim
{"title":"Pediatric Central Nervous System Vascular Malformation : Pathological Review with Diagram.","authors":"Se Hoon Kim","doi":"10.3340/jkns.2024.0006","DOIUrl":"10.3340/jkns.2024.0006","url":null,"abstract":"<p><p>Pediatric central nervous system (CNS) vascular malformations are a group of abnormal blood vessel formations within the brain or spinal cord in children. The most crucial point of pediatric CNS vascular malformation is that no golden standard classifications exist. In addition, there is a big gap in knowledge and the viewpoint of clinicians, radiologists, and pathologists. In addition, many genes associated with pediatric CNS vascular malformation, such as Sturge-Weber-Dimitri syndrome with guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) gene mutation, and cavernous malformations with cerebral cavernous malformations 1 (CCM1), CCM2, and CCM3 gene mutation, were recently revealed. For proper therapeutic approaches, we must understand the lesions' characterizations in anatomical, morphological, and functional views. In this review, the author would like to provide basic pediatric CNS vascular malformation concepts with understandable diagrams. Thus, the author hopes that it might be helpful for the proper diagnosis and treatment of CNS pediatric vascular malformations.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features and Treatment of Pediatric Cerebral Cavernous Malformations. 小儿脑腔畸形的临床特征和治疗。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 Epub Date: 2024-03-28 DOI: 10.3340/jkns.2024.0047
Ji Hoon Phi, Seung-Ki Kim
{"title":"Clinical Features and Treatment of Pediatric Cerebral Cavernous Malformations.","authors":"Ji Hoon Phi, Seung-Ki Kim","doi":"10.3340/jkns.2024.0047","DOIUrl":"10.3340/jkns.2024.0047","url":null,"abstract":"<p><p>Cerebral cavernous malformation (CCM) is a vascular anomaly commonly found in children and young adults. Common clinical presentations of pediatric patients with CCMs include headache, focal neurological deficits, and seizures. Approximately 40% of pediatric patients are asymptomatic. Understanding the natural history of CCM is crucial and hemorrhagic rates are higher in patients with an initial hemorrhagic presentation, whereas it is low in asymptomatic patients. There is a phenomenon known as temporal clustering in which a higher frequency of symptomatic hemorrhages occurs within a few years following the initial hemorrhagic event. Surgical resection remains the mainstay of treatment for pediatric CCMs. Excision of a hemosiderin-laden rim is controversial regarding its impact on epilepsy outcomes. Stereotactic radiosurgery is an alternative treatment, especially for deepseated CCMs, but its true efficacy needs to be verified in a clinical trial.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroid Plexus Hyperplasia : Report of Two Cases with Unique Radiologic Findings. 脉络丛增生：两例独特放射学表现的报告。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 Epub Date: 2023-10-18 DOI: 10.3340/jkns.2023.0126
Joo Whan Kim, Waka Hisamura, Seung-Ki Kim, Ji Hoon Phi
{"title":"Choroid Plexus Hyperplasia : Report of Two Cases with Unique Radiologic Findings.","authors":"Joo Whan Kim, Waka Hisamura, Seung-Ki Kim, Ji Hoon Phi","doi":"10.3340/jkns.2023.0126","DOIUrl":"10.3340/jkns.2023.0126","url":null,"abstract":"<p><p>Choroid plexus hyperplasia (CPH), also known as diffuse villous hyperplasia of choroid plexus, is a rare condition characterized by excessive production of cerebrospinal fluid (CSF), resulting in hydrocephalus. Diagnosing CPH can be challenging due to the absence of clear imaging criteria for choroid plexus hypertrophy and the inability to assess CSF production non-invasively. As a result, many CPH patients are initially treated with a ventriculoperitoneal (VP) shunt, but subsequently require additional surgical intervention due to intractable ascites. In our study, we encountered two CPH patients who presented with significantly enlarged subarachnoid spaces, reduced parenchymal volume, and prominent choroid plexus. Initially, we treated these patients with a VP shunt, but eventually opted for endoscopic choroid plexus cauterization (CPC) to address the intractable ascites. Following the treatment with endoscopic CPC, we observed a gradual reduction in subarachnoid spaces and an increase in parenchymal volume. In cases where bilateral prominent choroid plexus, markedly enlarged subarachnoid spaces, and cortical atrophy are present, CPH should be suspected. In these cases, considering initial treatment with combined endoscopic CPC and shunt may help minimize the need for multiple surgical interventions.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Expression of KIFC1 in Glioma Correlates with Poor Prognosis. 胶质瘤中 KIFC1 的高表达与预后不良有关
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-05-01 DOI: 10.3340/jkns.2023.0155
Pengfei Xue, Juan Zheng, Rongrong Li, Lili Yan, Zhaohao Wang, Qingbin Jia, Lianqun Zhang, Xin Li
{"title":"High Expression of KIFC1 in Glioma Correlates with Poor Prognosis.","authors":"Pengfei Xue, Juan Zheng, Rongrong Li, Lili Yan, Zhaohao Wang, Qingbin Jia, Lianqun Zhang, Xin Li","doi":"10.3340/jkns.2023.0155","DOIUrl":"10.3340/jkns.2023.0155","url":null,"abstract":"<p><strong>Objective: </strong>Kinesin family member C1 (KIFC1), a non-essential kinesin-like motor protein, has been found to serve a crucial role in supernumerary centrosome clustering and the progression of several human cancer types. However, the role of KIFC1 in glioma has been rarely reported. Thus, the present study aimed to investigate the role of KIFC1 in glioma progression.</p><p><strong>Methods: </strong>Online bioinformatics analysis was performed to determine the association between KIFC1 expression and clinical outcomes in glioma. Immunohistochemical staining was conducted to analyze the expression levels of KIFC1 in glioma and normal brain tissues. Furthermore, KIFC1 expression was knocked in the glioma cell lines, U251 and U87MG, and the functional roles of KIFC1 in cell proliferation, invasion and migration were analyzed using cell multiplication, wound healing and Transwell invasion assays, respectively. The autophagic flux and expression levels matrix metalloproteinase-2 (MMP2) were also determined using imaging flow cytometry, western blotting and a gelation zymography assay.</p><p><strong>Results: </strong>The results revealed that KIFC1 expression levels were significantly upregulated in glioma tissues compared with normal brain tissues, and the expression levels were positively associated with tumor grade. Patients with glioma with low KIFC1 expression levels had a more favorable prognosis compared with patients with high KIFC1 expression levels. In vitro, KIFC1 knockdown not only inhibited the proliferation, migration and invasion of glioma cells, but also increased the autophagic flux and downregulated the expression levels of MMP2.</p><p><strong>Conclusion: </strong>Upregulation of KIFC1 expression may promote glioma progression and KIFC1 may serve as a potential prognostic biomarker and possible therapeutic target for glioma.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Intracranial Vascular Malformations in Children : Radiological Overview. 儿童先天性颅内血管畸形：放射学概述。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-04-26 DOI: 10.3340/jkns.2024.0033
Jung-Eun Cheon, Ji Hye Kim
{"title":"Congenital Intracranial Vascular Malformations in Children : Radiological Overview.","authors":"Jung-Eun Cheon, Ji Hye Kim","doi":"10.3340/jkns.2024.0033","DOIUrl":"https://doi.org/10.3340/jkns.2024.0033","url":null,"abstract":"Prompt medical attention is crucial for congenital intracranial vascular malformations in children and newborns due to potential severe outcomes. Imaging is pivotal for accurate identification, given the diverse risks and treatment strategies. This article aims to enhance the identification and understanding of congenital intracranial vascular abnormalities including arteriovenous malformation, arteriovenous fistula, cavernous malformation, capillary telangiectasia, developmental venous anomaly, and sinus pericranii in pediatric patients.","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editors' Pick in May 2024. 2024 年 5 月编辑推荐。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-04-26 DOI: 10.3340/jkns.2024.0089
Hee-Jin Yang
{"title":"Editors' Pick in May 2024.","authors":"Hee-Jin Yang","doi":"10.3340/jkns.2024.0089","DOIUrl":"https://doi.org/10.3340/jkns.2024.0089","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paroxysmal Sympathetic Hyperactivity in the Acute Phase Post-Brain Tumour Surgery of Glioblastoma Multiforme. 多形性胶质母细胞瘤脑肿瘤手术后急性期的阵发性交感神经功能亢进。
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-04-23 DOI: 10.3340/jkns.2024.0026
Yasothai Sahadeevan, Mazlina Mazlan
{"title":"Paroxysmal Sympathetic Hyperactivity in the Acute Phase Post-Brain Tumour Surgery of Glioblastoma Multiforme.","authors":"Yasothai Sahadeevan, Mazlina Mazlan","doi":"10.3340/jkns.2024.0026","DOIUrl":"https://doi.org/10.3340/jkns.2024.0026","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Factors of Spinal Intramedullary Hemangioblastoma : Analysis of Surgical Outcomes and Tumor Characteristics. 脊髓髓内血管母细胞瘤的预后因素：手术效果和肿瘤特征分析
IF 1.6 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2024-04-23 DOI: 10.3340/jkns.2023.0221
Hyun Jun Jang, B. Moon, K. Kim, Jeong-Yoon Park, D. Chin, Yong-Eun Cho, Keun-Su Kim
{"title":"Prognostic Factors of Spinal Intramedullary Hemangioblastoma : Analysis of Surgical Outcomes and Tumor Characteristics.","authors":"Hyun Jun Jang, B. Moon, K. Kim, Jeong-Yoon Park, D. Chin, Yong-Eun Cho, Keun-Su Kim","doi":"10.3340/jkns.2023.0221","DOIUrl":"https://doi.org/10.3340/jkns.2023.0221","url":null,"abstract":"Objective\u0000Spinal intramedullary hemangioblastoma is a rare and highly vascularized benign tumor. The characteristics of the tumor, its corresponding location, and surgical outcomes remain unknown. The purpose of this study was to identify risk factors and strategies for neurologic deterioration following hemangioblastoma surgery.\u0000\u0000\u0000Methods\u0000A comprehensive retrospective analysis was undertaken to evaluate patients who underwent surgical intervention for intramedullary hemangioblastoma at our institution from 1993 to 2022. Patients with at least one year of follow-up data were included. The analysis covered patient demographics, pre- and post-operative Modified McCormick Scale (MMCS), tumor location, and tumor size.\u0000\u0000\u0000Results\u0000This study included 25 cases. One-year after surgery, neurological deterioration was observed in 5 (20.0%) cases, and neurological improvement was found in 9 (36.0%) cases. Five cases were ventrally located, and twelve cases were dorsally located. Ventrally located cases were larger in tumor axial size (p = 0.029) than dorsal location tumors, resulting in poorer follow-up MMCS and a higher prevalence of von Hippel-Lindau syndrome (VHL) (p = 0.042). Three of them were confirmed to be supplied by the anterior spinal artery. In the case of dorsally located cases, there was no neurologic deterioration.\u0000\u0000\u0000Conclusion\u0000In intramedullary spinal cord hemangioblastomas, cases located ventrally had a higher incidence of neurological deterioration following surgery than those located dorsally or in intramedullary extramedullary cases. Ventrally located hemangioblastomas were larger than those in other locations. They were mainly supplied by the anterior spinal artery in VHL patients.","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140666826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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