Journal of Korean Neurosurgical Society最新文献

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Allergic Reaction to a Bovine-Derived Dural Graft Without Eosinophilic Meningitis: A Case Report and Literature Review. 无嗜酸性粒细胞性脑膜炎的牛源硬脑膜移植物的过敏反应:1例报告和文献复习。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-18 DOI: 10.3340/jkns.2025.0092
Rose Fluss, Riana Lo Bu, Keyvan Ghadimi, Jason Yu, Maya Jurgens, Imane Abbas, Nagma Dalvi, Allison Martin, Andrew J Kobets
{"title":"Allergic Reaction to a Bovine-Derived Dural Graft Without Eosinophilic Meningitis: A Case Report and Literature Review.","authors":"Rose Fluss, Riana Lo Bu, Keyvan Ghadimi, Jason Yu, Maya Jurgens, Imane Abbas, Nagma Dalvi, Allison Martin, Andrew J Kobets","doi":"10.3340/jkns.2025.0092","DOIUrl":"https://doi.org/10.3340/jkns.2025.0092","url":null,"abstract":"<p><p>Bovine-derived dural substitutes are commonly used in cranial and spinal duraplasty. Although they are generally well tolerated, allergic reactions have been reported-almost all presented with eosinophilic meningitis. A 7-year-old girl with Li Fraumeni syndrome and diffuse pediatric glioma underwent a third salvage resection in which a bovine collagen dural onlay was placed. Ten days post operatively, she developed fever, lethargy, and a subcutaneous scalp fluid collection. Cultures and imaging were negative for infection; cerebrospinal fluid (CSF) revealed pleocytosis (elevated white blood cells and protein) without eosinophilia. High-dose dexamethasone produced transient clinical and radiographic improvement, but fever and fluid re accumulated whenever steroids were tapered. Given the steroid dependence and persistently negative infectious work up, the graft was explanted. Pathology demonstrated a foreign body giant cell reaction without eosinophils, and the patient's symptoms resolved permanently after removal. This report documents the first pediatric case of bovine-derived dural graft hypersensitivity without eosinophilic meningitis. Clinicians should consider graft-related allergy in children who develop recurrent fluid collections and fevers after duraplasty-even when CSF eosinophils are absent and cultures remain negative and should recognize that definitive treatment may require graft removal rather than prolonged steroid therapy.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Von Hippel-Lindau Disease : A Comprehensive Review of Diagnosis, Genetics, Clinical Challenges, and Surveillance" by Jung et al. (J Korean Neurosurg Soc 68 : 338-349, 2025). Jung等人对“Von Hippel-Lindau病:诊断,遗传学,临床挑战和监测的综合回顾”的更正(J Korean neurosurgery Soc 68: 338-349, 2025)。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-18 DOI: 10.3340/jkns.2025.0018.e1
{"title":"Corrigendum to \"Von Hippel-Lindau Disease : A Comprehensive Review of Diagnosis, Genetics, Clinical Challenges, and Surveillance\" by Jung et al. (J Korean Neurosurg Soc 68 : 338-349, 2025).","authors":"","doi":"10.3340/jkns.2025.0018.e1","DOIUrl":"https://doi.org/10.3340/jkns.2025.0018.e1","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editors' Pick in July 2025. 2025年7月的编辑选择。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-16 DOI: 10.3340/jkns.2025.0121
Hee-Jin Yang
{"title":"Editors' Pick in July 2025.","authors":"Hee-Jin Yang","doi":"10.3340/jkns.2025.0121","DOIUrl":"https://doi.org/10.3340/jkns.2025.0121","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Value of Texture Analysis in Postoperative Recurrence of Chronic Subdural Hematoma. 慢性硬膜下血肿术后复发的肌理分析价值。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-16 DOI: 10.3340/jkns.2024.0125
Yu Yan, Jianchao Wang, Jincai Fang, Yunnong Song
{"title":"The Value of Texture Analysis in Postoperative Recurrence of Chronic Subdural Hematoma.","authors":"Yu Yan, Jianchao Wang, Jincai Fang, Yunnong Song","doi":"10.3340/jkns.2024.0125","DOIUrl":"https://doi.org/10.3340/jkns.2024.0125","url":null,"abstract":"<p><strong>Objective: </strong>Texture analysis is widely used in all walks of life, and also in medicine. This paper aims to discuss the value of texture analysis in postoperative recurrence of chronic subdural hematoma (CSDH).</p><p><strong>Methods: </strong>A total of 173 patients with CSDH who were hospitalized in our hospital from January 2018 to August 2023 were selected . All the patients underwent magnetic resonance imaging (MRI) examinations before surgery. According to whether patients with CSDH have relapsed after surgery, the patients are divided into recurrence group and non-recurrence group. FireVoxel software (https://firevoxel.org) was used to manually delineate the region of interest on the largest level of the hematoma cavity during MRI plain scans and measure the texture parameters. The texture parameters with statistical difference were analyzed by receiver operating characteristic curve.</p><p><strong>Results: </strong>Heterogeneity and entropy texture parameters in the recurrence group were statistically different from those in the nonrecurrence group (p<0.05). When the cut-off point of the heterogeneity parameter was 0.284, the sensitivity, specificity, and accuracy of judging whether CSDH relapsed were 83.3%, 80.4%, and 80.7%, respectively.</p><p><strong>Conclusion: </strong>Texture analysis of CSDH can provide a new method to judge the recurrence of patients with CSDH.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lordosis Distribution Index in an Asymptomatic Elderly Population : The Role of Lower and Upper Lumbar Lordosis According to Individual Pelvic Incidence and Roussouly Type. 无症状老年人群腰椎前凸分布指数:根据个体骨盆发病率和Roussouly型,上下腰椎前凸的作用。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-10 DOI: 10.3340/jkns.2025.0086
Seung-Jae Hyun, Sanghyun Han, Youngbae B Kim
{"title":"Lordosis Distribution Index in an Asymptomatic Elderly Population : The Role of Lower and Upper Lumbar Lordosis According to Individual Pelvic Incidence and Roussouly Type.","authors":"Seung-Jae Hyun, Sanghyun Han, Youngbae B Kim","doi":"10.3340/jkns.2025.0086","DOIUrl":"https://doi.org/10.3340/jkns.2025.0086","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to elucidate the normative upper and lower lumbar lordosis (ULL and LLL) based on individual pelvic and spinal morphology within an asymptomatic elderly population.</p><p><strong>Methods: </strong>Whole spine standing radiographs were obtained from asymptomatic elderly populations who had not undergone previous spinal surgery. The lumbar lordosis (LL), lower LL and upper LL were measured. Pelvic incidence (PI) and the lordosis distribution index for the upper and lower lumbar spine (ULDI and LDI, respectively) were calculated. Pearson correlation and linear regression analyses were performed, and the mean value for each parameter was obtained according to PI subgroup (PI < 40°, 40° ≤ PI < 50°, 50° ≤ PI < 60°, and 60° ≤ PI) and \"theoretical\" Roussouly type.</p><p><strong>Results: </strong>Overall, data from 150 male were retrospectively collected in the study, with an average age of 64.1 ± 6.4 years. The mean height was 167.0 ± 5.5 cm, weight was 67.3 ± 9.8 kg, and body mass index was 24.1 ± 3.1 kg/m2. The average LL was -57.5° ± 9.0°, LLL was -39.7° ± 6.8°, and PI was 48.6° ± 8.6°. PT tended to increase with ULL, PI-LL, PI-ULL, PI-LLL, and ULDI and decrease with LLL and LDI. However, PT was not significantly related to LL. The mean ULDI and LDI were 30.4% ± 11.7% and 69.7% ± 11.7%, respectively. The differences between PI and LL (PI-LL) and between PI and LLL (PI-LLL) were -8.9° ± 8.0° and 9.0° ± 9.3°, respectively. As PI increased from low (<40°) to high (≥60°), ULDI increased significantly from 25.9% to 38.9%, while LDI decreased from 74.1% to 61.1%. Additionally, LDI varied by Roussouly type, ranging from 62.6% to 81.0%. The LDIs of Roussouly types 1 and 4 were significantly higher and lower, respectively, than those of types 2 and 3 (p < 0.001).</p><p><strong>Conclusion: </strong>As PI and Roussouly type increase, the contribution of ULL to overall LL rises, reaching up to 38.9%. Conversely, LLL substantially impacts LL in patients with a low PI and those classified as Roussouly type 1. PT is significantly related to LLL instead of LL according to PI.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factor Analysis of Simple Drainage Followed by Instrumented Fusion in Patients with Pyogenic Spinal Infection. 化脓性脊柱感染单纯引流后器械融合术的危险因素分析。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-09 DOI: 10.3340/jkns.2025.0084
Jong Tae Ko, Sang Hyub Lee, Tae Yong An, Dong Hwan Kim, Dong Ho Kang
{"title":"Risk Factor Analysis of Simple Drainage Followed by Instrumented Fusion in Patients with Pyogenic Spinal Infection.","authors":"Jong Tae Ko, Sang Hyub Lee, Tae Yong An, Dong Hwan Kim, Dong Ho Kang","doi":"10.3340/jkns.2025.0084","DOIUrl":"https://doi.org/10.3340/jkns.2025.0084","url":null,"abstract":"<p><strong>Objective: </strong>The first-line treatment for pyogenic spondylitis is conservative management with immobilization and systemic antibiotic therapy. However, in cases where conservative treatment fails or neurological deficits and spinal instability are present, surgical intervention is required. Surgical treatment helps manage spondylitis by decompressing neural structures through abscess drainage and maintaining spinal stability. It includes simple decompression via abscess removal, debridement of inflamed and necrotic tissues, and reconstruction with fixation. This study aims to analyze the risk factors associated with clinical outcomes in patients undergoing simple drainage followed by instrumented fusion.</p><p><strong>Methods: </strong>We retrospectively evaluated patients who underwent surgical treatment with intravenous antibiotics for pyogenic spondylitis at our hospital between March 2010 and November 2021. We categorized the study group into a group that underwent simple decompression and drainage and a group that was followed up until fusion. We compared the basic demographics, laboratory data, and radiological findings between the two groups.</p><p><strong>Results: </strong>Overall, 88 patients (50 males and 38 females) with a mean age of 63.8 years were included in this study. Of the 88 patients, 71 underwent simple abscess drainage and 17 underwent instrumented fusion. In the univariate logistic regression analysis based on demographic data, longer duration of antibiotic use (p=0.021), body signal change (p=0.001), facet inflammation (p=0.003), disc abscess (p<0.001), psoas abscess (p=0.003), disc space bone erosion (p=0.006), and hypertension (p=0.024) were significant risk factors for necessitation of fusion surgery after decompression and drainage surgery. Multivariate logistic regression analysis based on these risk factors revealed that the longer the period of total antibiotic use after decompression and drainage (p=0.019), the higher the risk of fusion surgery, as well as a higher risk of body signal change.</p><p><strong>Conclusion: </strong>When planning surgical treatment for pyogenic spondylitis, close observation is required because the necessity for instrumented fusion surgery increases when antibiotic use is prolonged or body signal changes are confirmed on magnetic resonance imaging.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Study on Clinical Outcomes of Posterior Endoscopic Cervical Foraminotomy under Local Anesthesia with Conscious Sedation and General Anesthesia. 局麻清醒镇静与全麻下后路内窥镜颈椎椎间孔切开术临床效果的比较研究。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-09 DOI: 10.3340/jkns.2024.0229
Jason K Lim, Marium Raza, Do H Lim, Samuel Kim, Jeffrey M Breton, David Zhao, Patrick Kim, Mani N Nair, Christoph P Hofstetter, Byeong Cheol Rim
{"title":"Comparative Study on Clinical Outcomes of Posterior Endoscopic Cervical Foraminotomy under Local Anesthesia with Conscious Sedation and General Anesthesia.","authors":"Jason K Lim, Marium Raza, Do H Lim, Samuel Kim, Jeffrey M Breton, David Zhao, Patrick Kim, Mani N Nair, Christoph P Hofstetter, Byeong Cheol Rim","doi":"10.3340/jkns.2024.0229","DOIUrl":"https://doi.org/10.3340/jkns.2024.0229","url":null,"abstract":"<p><strong>Objective: </strong>Posterior endoscopic cervical foraminotomy (PECF) is a minimally invasive surgical technique for treating cervical radiculopathy. Traditionally, PECF is performed under general anesthesia in the prone position, but concerns over anesthesia-related complications have led to the exploration of local anesthesia in the lateral decubitus position as an alternative. This study aims to compare the clinical outcomes, safety, and efficacy of PECF performed under local anesthesia in the lateral decubitus position versus general anesthesia in the prone position.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 13 patients who underwent PECF under local anesthesia in the lateral decubitus position. The outcomes were compared with data from 357 patients across eight studies who underwent PECF under general anesthesia in the prone position. Outcomes measures included visual analog scale (VAS) pain scores, Oswestry disability Index (ODI), length of stay (LOS), minimally clinically important difference (MCID), and complications.</p><p><strong>Results: </strong>Patients in the local anesthesia group demonstrated significant reductions in neck pain (VAS-N: 4.93±1.32 to 1.49±0.52, p<0.001) and arm pain (VAS-A: 8.69±0.75 to 1.85±1.46, p<0.001), achieving a mean pain reduction of 78.8%. These improvements were comparable to the general anesthesia group (VAS-N: 4.80 to 1.28; VAS-A: 6.71 to 1.23). Functional outcomes improved significantly in both groups, with ODI scores improving from 54.76% to 9.82% locally and from 39.92% to 9.62% in the general group. Although length of stay was slightly longer for the local anesthesia group (5.85±3.20 vs. 4.81±2.17 days, p=0.18), post-procedure monitoring time was significantly shorter (3.2 vs. 7.4 hours, p<0.001). The local anesthesia group reported zero complications (0%, 95% CI: 0-22.8%) compared to an 8.68% complication rate (95% CI: 5.8%-11.6%) in the general anesthesia cohort (p=0.612).</p><p><strong>Conclusion: </strong>PECF under local anesthesia in the lateral decubitus position provides comparably effective pain relief and functional improvement comparable to general anesthesia, though the difference in complication rates was not statistically significant and requires larger studies for confirmation. This technique may be particularly advantageous for patients at higher risk for anesthesia-related complications. Further research is warranted to validate these findings in larger, prospective studies.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-Segment Fixation with Anterior Support versus Long-Segment Fixation with Separation Surgery for Thoracolumbar Spinal Metastatic Tumors : A Comparative Analysis. 短节段与长节段固定治疗胸腰椎转移性肿瘤的临床和放射学结果:回顾性比较分析。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-09 DOI: 10.3340/jkns.2024.0208
Younggyu Oh, Subum Lee, Jinuk Kim, Seo Eun Kim, Jae Hwan Cho, Jin Hoon Park
{"title":"Short-Segment Fixation with Anterior Support versus Long-Segment Fixation with Separation Surgery for Thoracolumbar Spinal Metastatic Tumors : A Comparative Analysis.","authors":"Younggyu Oh, Subum Lee, Jinuk Kim, Seo Eun Kim, Jae Hwan Cho, Jin Hoon Park","doi":"10.3340/jkns.2024.0208","DOIUrl":"10.3340/jkns.2024.0208","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate and compare the clinical and radiographic outcomes of patients with metastatic spinal tumors who underwent either short-segment fixation with anterior support or long-segment fixation with a separation surgery in the thoracic or lumbar spine.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of adult patients who were treated surgically for spinal metastases in the thoracic or lumbar spine at a single tertiary referral center between April 2014 and December 2022. Surgical treatments included spinal cord decompression, short-segment fixation with maximal circumferential debulking of the lytic tumor portion and anterior support, or long-segment fixation without anterior support, followed by separation surgery and posterolateral fusion. We compared the two fixation strategies based on patient demographics, preoperative diagnoses, surgical data, neurological assessments, and changes in segmental Cobb angles immediately after surgery, and at the final follow-up.</p><p><strong>Results: </strong>A total of 91 patients were included (short-segment = 44, long-segment = 47). No significant differences were observed between the groups regarding age, sex, comorbidities, primary cancer location, postoperative complications, or reoperation rates. Furthermore, no significant differences in the sagittal Cobb angles, including global angle (thoracic kyphosis, lumbar lordosis) and segmental angle were noted from the preop to the final follow-up. Compared to traditional long-segment fixation, short-segment fixation with anterior support significantly improved neurological outcomes in the thoracic region and reduced the length of hospital stay. No significant differences were observed between the two groups regarding complications or other clinical outcomes.</p><p><strong>Conclusion: </strong>Short-segment fixation is comparable to long-segment fixation in the management of thoracolumbar metastatic spinal tumors, with no significant differences in radiographic outcomes. However, short-segment fixation provides the added advantages of improved neurological outcomes in the thoracic region and shorter hospital stays.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Transfusion Timing of Plasma and Red Blood Cells in a 1 : 1 Ratio Is Related with Survival and Functional Outcomes in Multiple Trauma Patients with Severe Traumatic Brain Injury. 重型颅脑损伤多发创伤患者血浆和红细胞输注时间1:1的比例与生存和功能预后相关
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-09 DOI: 10.3340/jkns.2025.0006
Donghwan Choi, Nam Kyu You, Hohyung Jung, Dongmin Seo, Jaeri Yoo, Tae Seok Jeong
{"title":"The Transfusion Timing of Plasma and Red Blood Cells in a 1 : 1 Ratio Is Related with Survival and Functional Outcomes in Multiple Trauma Patients with Severe Traumatic Brain Injury.","authors":"Donghwan Choi, Nam Kyu You, Hohyung Jung, Dongmin Seo, Jaeri Yoo, Tae Seok Jeong","doi":"10.3340/jkns.2025.0006","DOIUrl":"https://doi.org/10.3340/jkns.2025.0006","url":null,"abstract":"<p><strong>Objective: </strong>High-ratio plasma transfusion is proposed as a strategy for treating polytrauma with severe traumatic brain injury (TBI). This study analyzed outcomes based on the ratio and timing of plasma transfusion.</p><p><strong>Methods: </strong>The clinical characteristics and results were collected from March 2016 to December 2022. Subjects included patients with severe TBI and polytrauma who underwent massive transfusion (MT). Severe TBI was defined as Head Abbreviated Injury Score (AIS) ≥3, and MT was defined as packed Red Blood Cells ≥4 units in the first 4 h and ≥10 units in the first 24 h. The 4-h ratios were assigned to the \"Early group,\" and the 24-h ratios to the \"Catch-up group.\" Next, the ratio of each group was divided into \"≥1:1\" and \"<1:1\" groups, respectively.</p><p><strong>Results: </strong>In this study, 532 patients participated. Mortality rates between the 1:2 and 1:1.5 ratios did not differ statistically; however, a significant difference was noted only at the 1:1 ratio (p=0.006). In the Early group, outcomes did not significantly differ. The logistic regression for 30-d mortality identified independent risk factors, including advanced age, low Glasgow Coma Scale (GOS) scores, high AIS head scores, and a ratio <1:1. For the Catch-up group, the odds ratio for a favorable GOS at ≥1:1 was 1.61, with a 30-d mortality rate of 0.60 when comparing ≥1:1 to <1:1 ratios.</p><p><strong>Conclusion: </strong>This study showed that maintaining a ≥1:1 plasma ratio for 24 h improved functional outcomes and survival, without increased morbidity. Therefore, high-ratio plasma transfusion may be effective in the treatment of patients with polytrauma and severe TBI.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Dose Bone Morphogenetic Protein Use in Spinal Fusion : Rethinking Clinical Efficacy. 低剂量骨形态发生蛋白在脊柱融合术中的应用:对临床疗效的重新思考。
IF 1.4 4区 医学
Journal of Korean Neurosurgical Society Pub Date : 2025-06-02 DOI: 10.3340/jkns.2025.0025
Jun Ho Lee, Ji Hyun Youn, Hyun Jung Park, Seung-Jae Hyun
{"title":"Low-Dose Bone Morphogenetic Protein Use in Spinal Fusion : Rethinking Clinical Efficacy.","authors":"Jun Ho Lee, Ji Hyun Youn, Hyun Jung Park, Seung-Jae Hyun","doi":"10.3340/jkns.2025.0025","DOIUrl":"https://doi.org/10.3340/jkns.2025.0025","url":null,"abstract":"<p><p>In spinal fusion surgery, autogenous bone grafting remains the gold standard for achieving optimal bone fusion; however, challenges such as donor site morbidity and limited graft availability have prompted active research into alternative options. Recombinant human bone morphogenetic protein-2 (rhBMP-2) exhibits excellent osteoinductive properties. Using rhBMP-2 was anticipated to promote early and effective fusion, particularly in challenging surgical scenarios involving elderly patients, those with low bone density, or individuals with multiple comorbidities, although in these populations, the biological response to rhBMP-2 may be attenuated and the risk of complications increased. This review provides a comprehensive overview of the development, characteristics, and dose-related adverse reactions of rhBMP-2 in spinal fusion, based on extensive clinical and experimental findings. Factors contributing to the decline in rhBMP-2 usage are also discussed. Furthermore, this review proposes a safer carrier with reduced rhBMP-2 doses to optimize delivery and minimize complications. Emphasis is placed on the critical role of carriers in improving bioavailability control, minimizing side effects, and better aligning with natural bone healing processes.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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