Journal of Korean Neurosurgical Society最新文献

{"title":"The Biomarkers and Underlying Mechanisms of Mitochondrial and Programmed Cell Death Related Genes in Epilepsy by Combining Transcriptome and Single-Cell Sequencing.","authors":"Wang Xiaoqiang, Wang Ren, Zhang Jianglong","doi":"10.3340/jkns.2024.0230","DOIUrl":"10.3340/jkns.2024.0230","url":null,"abstract":"<p><strong>Objective: </strong>Reactive oxygen species generated by mitochondria contribute to the induction of programmed cell death (PCD), but their involvement in epilepsy remains uncertain. The present study investigates the biomarkers and underlying mechanisms of mitochondriarelated genes (MRGs) and PCD-related genes (PCDRGs) in epilepsy.</p><p><strong>Methods: </strong>The MRGs and PCDRGs were respectively intersected with differentially expressed genes in epilepsy and control samples within the GSE134697. Afterwards, Spearman correlation analysis was implemented to select candidate genes. Thereafter, candidate biomarkers were identified through intersection of eight algorithm results in cytoHubba plugin. The receiver operating characteristic curve analysis and expression validation in GSE134697 and GSE168375 were implemented to select biomarkers. Moreover, functional analysis, drug prediction and molecular docking were carried out to explore the mechanism of biomarkers in epilepsy, as well as single cell RNA sequencing analysis. Finally, the expression of biomarkers in clinical sample was validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR).</p><p><strong>Results: </strong>LTBR and IRF1 were down-regulated in epilepsy samples in both GSE134697 and GSE168375 datasets, Therefore, they were identified as biomarkers for epilepsy related to PCD and mitochondria. IRF1 formed a hydrogen bond interaction with the recombinant cytokine, indicating recombinant cytokine was an effective drug target, while LTBR was not a suitable drug target. The macrophage was observed to engage in more frequent and intensive interactions with other cells. RT-qPCR showed that both biomarkers also low expression in epilepsy clinical samples.</p><p><strong>Conclusion: </strong>LTBR, IRF1 were identified as biomarkers associated with mitochondria and PCD in epilepsy, providing novel perspectives on the management of this condition.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"196-214"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Erythrocyte Sedimentation Rate/C-Reactive Protein Ratio and Procalcitonin Values in Postoperative Spondylodiscitis : Potential Biomarker Comparison.","authors":"Ömer Faruk Şahin, Oğuzhan Uzlu, Bekir Tunç, Ali Yılmaz, Mağruf İlkay Yapakcı, Ahmet Burak Gürpınar","doi":"10.3340/jkns.2025.0067","DOIUrl":"10.3340/jkns.2025.0067","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative spondylodiscitis is a rare but serious complication of spinal surgery. The difficulty in establishing an early diagnosis necessitates the evaluation of novel biomarkers. This study aims to determine the diagnostic value of procalcitonin (PCT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ESR/CRP, and ESR/PCT ratios in the diagnosis of postoperative spondylodiscitis and to compare the sensitivity and specificity of these parameters.</p><p><strong>Methods: </strong>This retrospective study was conducted by evaluating 55 patients who underwent two-level lumbar instrumentation (foraminotomy-medial facetectomy and microdiscectomy, autologous graft with fusion) between 2019 and 2023. Laboratory values of 28 patients diagnosed with postoperative spondylodiscitis and 27 control patients with no signs of infection were analyzed. The cut-off values, sensitivity, specificity, positive and negative predictive values, and area under the curve (AUC) of CRP, ESR, PCT, ESR/CRP, and ESR/PCT ratios were calculated using receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>CRP, ESR, and PCT levels were significantly elevated in patients with spondylodiscitis (p<0.05). The ESR/PCT ratio demonstrated 96% specificity and was considered a supportive marker for the diagnosis of spondylodiscitis. However, the ESR/CRP ratio did not show a significant difference between the two groups (p=0.222). The cut-off value for CRP was determined as 43.7 mg/L, with a specificity of 100%. The cut-off value for ESR was 46 mm/hr, with a sensitivity of 92.9%. The cut-off value for PCT was found to be 0.034 ng/mL, with a sensitivity of 96.2%.</p><p><strong>Conclusion: </strong>CRP and ESR/PCT ratios were found to be effective in supporting the diagnosis of postoperative spondylodiscitis due to their high specificity. On the other hand, ESR and PCT demonstrated higher sensitivity, making them more successful in distinguishing non-infected individuals. However, no single biomarker was deemed sufficient on its own, emphasizing the necessity of clinical evaluation alongside laboratory findings. Prospective studies are needed in the future to enhance the diagnostic accuracy of these biomarkers.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"225-230"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Serum Prestin as a Potential Biomarker for Trauma Severity in Patients with Traumatic Brain Injury.","authors":"Abdulaziz Yalınkılıç, Zübeyir Huyut, Mehmet Edip Akyol, Damla Ayan Gündemir, Mehmet Tahir Huyut, Yaser Said Çetin","doi":"10.3340/jkns.2025.0143","DOIUrl":"10.3340/jkns.2025.0143","url":null,"abstract":"<p><strong>Objective: </strong>Prestin, expressed in cochlear outer hair cells, is essential for auditory signal amplification and may serve as a biomarker for cochlear injury related to trauma. This study aimed to investigate the potential role of prestin in the diagnosis and prognosis of cranial trauma.</p><p><strong>Methods: </strong>A total of 150 participants were included, comprising 110 patients aged 18-70 who were treated for head trauma and 40 age-matched healthy controls. The patients were divided into two groups of 55 each, with Glasgow coma scale (GCS) ≥13 and GCS ≤8, according to the GCS. Prestin was measured by enzyme-linked immunosorbent assay in serum on days 1, 3, and 7 in the patient and also the control groups. In the diagnosis of trauma and determining trauma severity, important risk levels (cut-off values) according to prestin's measurement days were calculated by receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Prestin values in both the GCS ≥13 and GCS ≤8 groups were dramatically lower than those in the control on all measurement days. Additionally, prestin values in the GCS ≤8 group on days 3 and 7 tended to be lower than those in the GCS ≥13 group. Furthermore, there was a tendency for serum prestin values to increase as time progressed especially in the GCS ≥13 group. ROC analysis showed that prestin values on the first, third, and seventh days showed high accuracy in detecting traumatized individuals with area under the curve (AUC) values of 85%, 81%, and 75%, respectively (sensitivity : 84%, 79%, and 83%, respectively). Also, prestin data on the first day accurately detected the severity of trauma at a high rate (sensitivity, 82%; AUC, 90%).</p><p><strong>Conclusion: </strong>Our findings suggest that serum prestin levels on the first day after trauma may provide supportive information regarding trauma severity. However, further controlled studies are needed before definitive diagnostic or prognostic use.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"186-195"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Recurrent Herniation Surgery with Biportal Endoscopic Discectomy : A Comparison of Biportal Endoscopic Discectomy and Microscopic Discectomy for Recurrent Disc Herniation.","authors":"Sang Youp Han, Sang Hyub Lee, Jae-Won Jang, Dong-Geun Lee, Yong Eun Cho, Choon-Keun Park, Il Sup Kim","doi":"10.3340/jkns.2025.0083","DOIUrl":"10.3340/jkns.2025.0083","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to compare the clinical outcomes of unilateral biportal endoscopic (UBE) lumbar discectomy and open lumbar microdiscectomy (MD) for recurrent disc herniation.</p><p><strong>Methods: </strong>Ninety patients who underwent discectomy, including 44 and 46 who underwent UBE and MD, respectively, were enrolled. All surgeries were performed between March 2020 and April 2023. Only patients with single-level recurrence were included; patients with multilevel recurrence or unstable disease, as well as those who had undergone surgery less than 6 months prior, were excluded. Visual analog scale (VAS) scores, recurrence rates, and complications were compared between the groups.</p><p><strong>Results: </strong>The average follow-up periods were 19.09 and 20.45 months in the UBE revision and MD revision discectomy groups, respectively. The mean bleeding loss and hospital stay were shorter in the UBE group than in the MD group. Postoperative short-term back pain was lower in the UBE group (VAS score, 3.32) than in the MD group (VAS score, 7.89) (p<0.001). Radiating pain showed similar patterns in both groups at all time points. Recurrence was more frequent in the MD group; however, this difference did not reach statistical significance, likely owing to the small sample size (p=0.677). Similarly, incidental durotomy occurred less frequently in the UBE group (6.8% vs. 8.7%), but this difference was not statistically significant.</p><p><strong>Conclusion: </strong>Both UBE and MD could achieve good long-term outcomes; however, UBE revision was superior in terms of short-term back pain, bleeding loss, and length of hospital stay after surgery.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"231-237"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing for the Resumption of Anticoagulants after Intracranial Hemorrhage.","authors":"Sejin Choi, Myoung-Jin Jang, Kangmin Kim, Won-Sang Cho, Hyun-Seung Kang, Jeong Eun Kim, Sung Ho Lee","doi":"10.3340/jkns.2025.0112","DOIUrl":"10.3340/jkns.2025.0112","url":null,"abstract":"<p><strong>Objective: </strong>To identify the ideal timing for resuming oral or injectable anticoagulants therapy after spontaneous intracranial hemorrhage (sICH).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study involving 90 patients from a tertiary hospital in Korea, between June 2000 and May 2022, who had experienced sICH while receiving anticoagulant therapy and who resumed treatment within 6 months. Exclusions were made for trauma-induced hemorrhages and early post-ictus fatalities. The interval between sICH occurrence and anticoagulant resumption was the main exposure variable. We evaluated hemorrhagic and thromboembolic events as outcomes. Multivariate analysis was used to determine the risk factors for post-resumption complications. Receiver operating characteristic (ROC) and locally estimated scatterplot smoothing (LOESS) were used to identify optimal timing.</p><p><strong>Results: </strong>The median patient age was 71 years, with 56.7% male. Warfarin was the most commonly used anticoagulant prior to sICH (63.3%), and non-vitamin K antagonist oral anticoagulants (NOACs) were used in 22.2%. Within 6 months of resuming anticoagulants, nine patients experienced hemorrhagic and 13 experienced ischemic complications. Age ≥80 years was significantly associated with ischemic events (odds ratio [OR], 4.29; p=0.048), while NOAC use was strongly associated with hemorrhagic complications (OR, 16.59; p=0.003). ROC analyses suggested possible cut-off points for anticoagulants resumption at day 30 for ischemic risk and day 7.5 for hemorrhagic risk, though AUC values were not statistically significant. Risk modeling using LOESS curves indicated that the combined complication risk was lowest when anticoagulants were resumed between days 20 and 22 after ictus.</p><p><strong>Conclusion: </strong>The findings suggest that approximately 3 weeks after sICH is the optimal time to resume anticoagulants, minimizing the risk of rebleeding or thromboembolic events. These findings may inform clinical decision-making in a broad patient population, though individualized assessment remains essential.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"215-224"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Lumboperitoneal Shunt Surgery for Normal Pressure Hydrocephalus : A 5-Year Single-Center Retrospective Study of Patients with at Least 1 Year of Follow-Up.","authors":"Ki-Su Park, Minjoon Kim, Taegon Kim, Seongyun Kim, Seong-Hyun Park, Eunhee Park, Kyunghun Kang","doi":"10.3340/jkns.2025.0094","DOIUrl":"10.3340/jkns.2025.0094","url":null,"abstract":"<p><strong>Objective: </strong>Lumboperitoneal shunt (LPS) surgery is a widely used treatment for normal pressure hydrocephalus (NPH), especially in East Asia. Although LPS surgery has been widely studied internationally, large-scale data from the Republic of Korea are limited. This study aimed to evaluate clinical outcomes and complications of LPS surgery in NPH patients, with particular focus on anesthesia type and valve pressure management strategies.</p><p><strong>Methods: </strong>A retrospective review was conducted of 244 patients with NPH who underwent LPS surgery between February 2020 and February 2025. Valve pressures were initially set at the highest level and gradually adjusted downward based on clinical response. Functional outcomes-including the modified Rankin scale (mRS), timed up and go (TUG), 10-m gait test, and Mini-Mental State Examination (MMSE)-were assessed at 1 year and followed for up to 4 years. Complications were categorized by type and whether surgical intervention was required.</p><p><strong>Results: </strong>Among 244 patients, 119 completed at least 1 year of follow-up. At 1 year, 53.8% of patients showed mRS improvement, and 66.4% demonstrated gait improvements (TUG and 10-m walk). Stable or improved function was observed in 93.3% of patients. MMSE scores did not show significant change. The overall complication rate was 16.8%, with 11.1% requiring surgical revision, primarily for chronic subdural hematoma and catheter-related issues. No surgery-related mortality occurred, but three patients (1.2%) died from falls despite improved gait, underscoring the need for fall prevention. The adoption of an initial high-pressure setting reduced overdrainage-related complications, contributing to a decreased annual revision rate of 5.6%.</p><p><strong>Conclusion: </strong>A retrospective study showed that LPS surgery with local anesthesia is effective for NPH patients, demonstrating favorable functional outcomes and acceptable complications. Using higher initial valve pressures significantly decreased the need for revision surgeries and complications related to overdrainage.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"286-298"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors' Pick in March 2026.","authors":"Hee-Jin Yang","doi":"10.3340/jkns.2025.0055","DOIUrl":"10.3340/jkns.2025.0055","url":null,"abstract":"","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":"69 2","pages":"173-175"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile of Neurosurgical Consultations from the Emergency Department : A Retrospective Analysis.","authors":"Bekir Tunç, Oğuzhan Uzlu, Ömer Faruk Şahin, Egemen Ünal","doi":"10.3340/jkns.2025.0160","DOIUrl":"10.3340/jkns.2025.0160","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to retrospectively analyze consultations requested from the emergency departments (EDs) to the neurosurgery (NS) department of a tertiary care hospital, and to comprehensively evaluate the clinical characteristics, referral reasons, and diagnostic and therapeutic processes of these patients. In addition, the study aims to provide concrete recommendations for strategic objectives such as optimizing hospital workflow, enhancing interphysician coordination, and standardizing consultation processes.</p><p><strong>Methods: </strong>This single-center, retrospective study evaluated patients who presented to the ED of a tertiary care hospital and for whom a neurosurgical consultation was requested between January 1, 2024 and December 31, 2024. Demographic data, consultation request notes prepared by emergency physicians, consultation responses provided by NS specialists, and radiological imaging findings of the patients were reviewed in detail.</p><p><strong>Results: </strong>Of the patients, 69% were consulted for traumatic and 31% for non-traumatic reasons. Among traumatic cases, falls were identified as the most common cause, whereas headache and altered mental status were the leading reasons in non-traumatic cases. Of the 386 patients, did not require neurosurgical intervention and were safely directed to clinical follow-up, representing the majority of NS consultations (44.8%). Surgical intervention was performed in 40 of 386 patients (10.3%). The frequency of consultations was notably higher during the summer months.</p><p><strong>Conclusion: </strong>The increase in admissions during the summer months demonstrates the necessity of planning adapted to seasonal workload. In pediatric head trauma, the application of the Pediatric Emergency Care Applied Research Network rules, and in suspected cauda equina syndrome, performing joint history-taking and physical examination, may enhance diagnostic accuracy and reduce unnecessary imaging. In cases of spontaneous subarachnoid hemorrhage and spontaneous intracerebral hemorrhage, rapid access can be strengthened through telemedicine, artificial intelligence-assisted analysis, and joint educational meetings.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"247-255"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Quality Assurance Guidelines for Gamma Knife Radiosurgery in Republic of Korea : A Multi-institutional Survey.","authors":"Hyeong Cheol Moon, Jong Hyeok Kwak, Seong Jin Jin, Byungmok Kim, Yong-Seok Im, Gyeong Rip Kim","doi":"10.3340/jkns.2025.0118","DOIUrl":"10.3340/jkns.2025.0118","url":null,"abstract":"<p><strong>Objective: </strong>The Leksell Gamma Knife (LGK) is one of the most precise radiosurgical tools available. However, the quality assurance (QA) practices for LGK vary considerably across institutions in Korea. In this study, we aim to identify and standardize key QA items, categorized into daily, monthly, biannual, and annual protocols, based on a nationwide survey conducted at 16 medical centers. Additionally, the tolerance values for each QA items were reviewed, comparing them with the American Association of Physicists in Medicine Task Group (TG-178), and tailored to establish distinct Korean Gamma Knife radiosurgery (GKRS) tolerances reflecting local standards and regulatory requirements.</p><p><strong>Methods: </strong>The survey focused on QA practices for the LGK IconTM/EspritTM and PerfexionTM systems. The QA items were categorized into daily, monthly, biannual, and annual tasks in accordance with the guidelines set by TG-178. Sixteen participating institutions were asked to rate the importance of each QA item on a scale of 0 (not important) to 5 (extremely important). Items rated 4 or 5 were selected to create a national priority list.</p><p><strong>Results: </strong>Eleven daily, six monthly, and three annual QA items were identified as high priority. Daily QA tasks primarily focused on radiation and patient safety, whereas the monthly tasks were largely related to dosimetric validation. Annual QA emphasizes mechanical and dosimetric checks. Biannual evaluations were not prioritized as they were routinely performed by the manufacturer's maintenance service (Elekta AB, Stockholm, Sweden).</p><p><strong>Conclusion: </strong>We succeeded in making recommendations for Gamma Knife QA standardization in Korea. Continuous QA updates are essential to ensure treatment safety, particularly with the introduction of new LGK models. These findings may contribute to the development of unified national QA guidelines for GKRS.</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"299-306"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Diagnostic Yield of the New Albert-Wong Stereotactic Frame and Its Comparison with the Cosman-Robert-Wells Frame for Brain Biopsy.","authors":"Kugan Vijian, Lau Bik Liang, Donald Ngian San Liew, Zamzuri Idris, Abdul Rahman Izaini Ghani, Jafri Malin Abdullah, Albert Wong Sii Hieng","doi":"10.3340/jkns.2025.0090","DOIUrl":"10.3340/jkns.2025.0090","url":null,"abstract":"<p><strong>Objective: </strong>The Albert-Wong (AW) stereotactic frame for brain biopsy was created by a Malaysian neurosurgeon in 2015. A phantombased accuracy study demonstrated that its accuracy was non-inferior to well-established stereotactic frames. The objective of our study is to compare the diagnostic yield and accuracy between two stereotactic frame systems : the Cosman-Robert-Wells (CRW) and AW frame.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study. All patients who had undergone frame-based biopsy for intracranial lesions using the CRW or AW frame from the year 2014 to 2022 were included in this study. Sociodemographic details, biopsy characteristics, and histopathological reports were collected, tabulated, and analyzed. A p-value of <0.05 was regarded as statistically significant.</p><p><strong>Results: </strong>A total of 38 patients underwent frame-based stereotactic biopsy from January 2014 to January 2022. The CRW frame was used for 19 (50%) of the patients, and the remaining utilized the AW frame. Deep lesions were biopsied in 27 (71%) of the patients, and the overall diagnostic yield was 89.5%. When comparing sociodemography and lesion characteristics between the CRW and AW frame groups, no statistically significant differences were found. The diagnostic yield and accuracy of these frames were 100% vs. 84% and 100% vs. 90% (AW vs. CRW), respectively, with no statistical difference between them (p>0.05).</p><p><strong>Conclusion: </strong>This study found that biopsies with the AW frame demonstrated diagnostic yield and accuracy which were non-inferior to the older more established frame (CRW).</p>","PeriodicalId":16283,"journal":{"name":"Journal of Korean Neurosurgical Society","volume":" ","pages":"265-271"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}