Journal of Medical Case Reports最新文献

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Subdural empyema-a rare complication of chronic otitis media: a case report. 硬膜下积液--慢性中耳炎的罕见并发症:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-08-03 DOI: 10.1186/s13256-024-04671-4
Emnet Tekeste Fekadu, Nahom Daniel, Samuel Tekle Mengistu, Genet Tekeste Fekadu
{"title":"Subdural empyema-a rare complication of chronic otitis media: a case report.","authors":"Emnet Tekeste Fekadu, Nahom Daniel, Samuel Tekle Mengistu, Genet Tekeste Fekadu","doi":"10.1186/s13256-024-04671-4","DOIUrl":"10.1186/s13256-024-04671-4","url":null,"abstract":"<p><strong>Background: </strong>Subdural empyema is an extremely rare and fatal intracranial complication of chronic otitis media. Due to its rarity and vague symptoms, it is often diagnosed late if not completely missed; specially in developing countries where the diagnostic modalities are hardly available or accessible. To the best knowledge of the authors, this is a preliminary reported case of subdural empyema as a complication of chronic otitis media in Eritrea. It aims to provide vital information on the clinical presentation, preferred diagnostic modalities, and the proper management of such cases.</p><p><strong>Case report: </strong>An 8 years old female patient from the Rashaida ethnic group presented with fever, right ear purulent discharge, right post-auricular swelling, and altered mental status. Prior to her admission, she had history of recurrent purulent discharge from her right ear for almost 2 years, and had been diagnosed with chronic otitis media. Upon admission her GCS was 13/15 which later on deteriorated to be 3/15 on day 3. MRI was done and showed a right fronto-tempo-parietal subdural empyema with mass effect, shifting the midline to the left. She was immediately started on empirical broad-spectrum antibiotics. After the diagnosis was made, craniotomy was done, and 30 ml of pus was removed from the subdural space. Culture and sensitivity of the pus obtained intraoperatively was done but produced no yield. Hence, she was continued on the empirically started antibiotics. The patient's condition was well improved by post-operative day 4.</p><p><strong>Conclusion: </strong>It is important to have a high index of suspicion of intracranial complications in patients with history of chronic otitis media or other otologic complaints, who present with neurologic manifestations. Subdural empyema still being uncommon even among the intracranial complications of COM, it is often missed. Hence, timely diagnosis with MRI, immediate surgical evacuation of the empyema along with the prolonged administration of broad-spectrum antibiotics is highly recommended.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connected to the cloud at time of death: a case report. 死亡时与云连接:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-08-03 DOI: 10.1186/s13256-024-04573-5
Isabel Straw, Claire Kirkby, Preethi Gopinath
{"title":"Connected to the cloud at time of death: a case report.","authors":"Isabel Straw, Claire Kirkby, Preethi Gopinath","doi":"10.1186/s13256-024-04573-5","DOIUrl":"10.1186/s13256-024-04573-5","url":null,"abstract":"<p><strong>Background: </strong>Our case report provides the first clinical evaluation of autopsy practices for a patient death that occurs on the cloud. We question how autopsy practices may require adaptation for a death that presents via the 'Internet of Things', examining how existing guidelines capture data related to death which is no longer confined to the patient's body.</p><p><strong>Case presentation: </strong>The patient was a British man in his 50s, who came to the attention of the medical team via an alert on the cloud-based platform that monitored his implanted cardioverter defibrillator (ICD). The patient had a background of congenital heart disease, with previous ventricular fibrillation cardiac arrest, for which the ICD had been implanted two years earlier. Retrospective analysis of the cloud data demonstrated a gradually decreasing nocturnal heart rate over the previous three months, falling to a final transmission of 24 beats per minute (bpm). In the patient post-mortem the ICD was treated as medical waste, structural tissue changes precluded the effective evaluation of device hardware, potential issues related to device software were not investigated and the cause of death was assigned to underlying heart failure. The documentation from the attending law enforcement officials did not consider possible digital causes of harm and relevant technology was not collected from the scene of death.</p><p><strong>Conclusion: </strong>Through this patient case we explore novel challenges associated with digital deaths including; (1) device hardware issues (difficult extraction processes, impact of pathological tissue changes), (2) software and data limitations (impact of negative body temperatures and mortuary radio-imaging on devices, lack of retrospective cloud data analysis), (3) guideline limitations (missing digital components in autopsy instruction and death certification), and (4) changes to clinical management (emotional impact of communicating deaths occurring over the internet to members of family). We consider the implications of our findings for public health services, the security and intelligence community, and patients and their families. In sharing this report we seek to raise awareness of digital medical cases, to draw attention to how the nature of dying is changing through technology, and to motivate the development of digitally appropriate clinical practice.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient with Herlyn-Werner-Wunderlich syndrome and endometriosis achieves successful full-term pregnancy (40 weeks and 6 days): a case report. Herlyn-Werner-Wunderlich 综合征和子宫内膜异位症患者成功足月妊娠(40 周零 6 天):病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-08-03 DOI: 10.1186/s13256-024-04695-w
Juliana Vieira Queiroz Almeida Oliveira, Chris Elizabeth Philip, Thayná Andreza Ribeiro Pereira, Gabriela Martins Perez Garcia, Quésia Tamara Mirante Ferreira Villamil
{"title":"Patient with Herlyn-Werner-Wunderlich syndrome and endometriosis achieves successful full-term pregnancy (40 weeks and 6 days): a case report.","authors":"Juliana Vieira Queiroz Almeida Oliveira, Chris Elizabeth Philip, Thayná Andreza Ribeiro Pereira, Gabriela Martins Perez Garcia, Quésia Tamara Mirante Ferreira Villamil","doi":"10.1186/s13256-024-04695-w","DOIUrl":"10.1186/s13256-024-04695-w","url":null,"abstract":"<p><strong>Introduction: </strong>Herlyn-Werner-Wunderlich syndrome , a rare Müllerian ducts congenital disease, is characterized by a diphtheritic uterus, blind hemivagina, and ipsilateral renal agenesis. Diagnosis is at young age by ultrasound and magnetic resonance imaging, and the prognosis is good. Usually, complications evolve endometriosis and secondary pelvic inflammation.</p><p><strong>Case report: </strong>A 40-year-old female patient, Brazilian, white, primigravida, diagnosed at 30 years with a didelphic uterus on ultrasound, and 4 years later, with a left ovarian endometrioma, multiple ovarian cysts, and left renal agenesis on magnetic resonance imaging. Subsequently, due to dyspareunia and a feeling of swelling, the patient underwent transvaginal ultrasound with bowel preparation, and a hematocolpos was found and Herlyn-Werner-Wunderlich syndrome was suspected; 10 years after the diagnosis she had a planned pregnancy. She presented frequent contractions following the 15th week of pregnancy and fortunately there were no complications or premature labor. Labor was inducted at 40 weeks and 6 days without progress and a cesarean section was indicated and performed without complications. Herlyn-Werner-Wunderlich syndrome often goes unnoticed, leading to inadequate treatment. Individuals with Herlyn-Werner-Wunderlich syndrome commonly face fertility issues, such as high miscarriage rate (21-33%), and obstetric complications, such as spontaneous abortions (40% risk), intrauterine growth restriction, postpartum hemorrhage, increased fetal mortality, preterm delivery (21-29%), and elevated rates of cesarean sections. In addition, there is higher susceptibility of developing endometriosis, especially with hemivaginal obstruction, and pelvic adhesions.</p><p><strong>Conclusion: </strong>Early diagnosis enables timely treatment and, consequently, fewer complications. Still, when these factors are absent, vaginal birth may still be possible. The true prevalence and incidence of complications related to Herlyn-Werner-Wunderlich syndrome are still unknown.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary pulmonary meningioma presenting as a pulmonary ground glass nodule: a case report and review of the literature. 表现为肺磨玻璃结节的原发性肺脑膜瘤:病例报告和文献综述。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-08-02 DOI: 10.1186/s13256-024-04668-z
Shengliang Zhao, Xiaoqing Liu, Mingzhang Xiang, Jigang Dai
{"title":"Primary pulmonary meningioma presenting as a pulmonary ground glass nodule: a case report and review of the literature.","authors":"Shengliang Zhao, Xiaoqing Liu, Mingzhang Xiang, Jigang Dai","doi":"10.1186/s13256-024-04668-z","DOIUrl":"10.1186/s13256-024-04668-z","url":null,"abstract":"<p><strong>Background: </strong>A primary pulmonary meningioma is an extremely rare entity. Primary pulmonary meningiomas manifested with a ground glass nodule are a very rare occurrence in clinical practice.</p><p><strong>Case presentation: </strong>In this study, we report a case of a primary pulmonary meningioma with atypical computed tomography features. A 59-year-old Han Chinese female came to our hospital for treatment and reported that her physical examination revealed a ground glass nodule in the right lung for over 3 months. The histologic result revealed a primary pulmonary meningioma. The patient underwent a thoracoscopic lung wedge resection of the right upper lobe for a ground glass nodule. After 1 year of follow-up, the patient is still alive without evidence of metastasis or recurrence.</p><p><strong>Conclusions: </strong>Primary pulmonary meningiomas could have a variety of radiological findings. As there are no specific radiologic features for the diagnosis of primary pulmonary meningiomas, complete resection of the lesion is required for both diagnosis and treatment. It is necessary to note the imaging features of primary pulmonary meningiomas, presenting as a ground glass nodule; this rare tumor should be considered in differential diagnoses.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe hypoglycemia in a diabetic patient with pituitary apoplexy: a case report. 脑垂体瘫痪糖尿病患者的严重低血糖症:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-08-01 DOI: 10.1186/s13256-024-04642-9
Binyam Melese Getahun, Medhanet Azene Gebeyehu, Amsalu Molla Getahun, Yoseph Gebremedhin Kassie
{"title":"Severe hypoglycemia in a diabetic patient with pituitary apoplexy: a case report.","authors":"Binyam Melese Getahun, Medhanet Azene Gebeyehu, Amsalu Molla Getahun, Yoseph Gebremedhin Kassie","doi":"10.1186/s13256-024-04642-9","DOIUrl":"10.1186/s13256-024-04642-9","url":null,"abstract":"<p><strong>Introduction: </strong>Hypoglycemia is a common occurrence in diabetic patients. But unlike non diabetic patients, its causes are frequently related to drugs they are receiving to control blood glucose. But this may not always be the case. Here we report a type 2 diabetic patient with severe hypoglycemia owing to acute hypopituitarism secondary to pituitary apoplexy.</p><p><strong>Case presentation: </strong>A 45 year old male diabetic patient from Ethiopia taking 2 mg of oral glimepiride daily who presented with change in mentation of 30 minutes and blood glucose recording of 38 mg/dl upon arrival to the emergency room. Brain magnetic resonance imaging showed pituitary macroadenoma with hemorrhage suggestive of pituitary apoplexy. Blood work up showed low adrenocorticotropic hormone, cortisol, and serum sodium levels. Subsequently transsphenoidal hypophysectomy was done.</p><p><strong>Conclusion: </strong>The occurrence of hypoglycemia in a diabetic patient taking sulphonylurea monotherapy is common. But when it is severe enough to cause altered mentation, patients should be approached differently. In the presence of clinical clues suggesting cortisol deficiency, hypopituitarism can be a possible cause.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphomatosis cerebri caused by adult T cell leukemia/lymphoma: a differential diagnosis for depression: a case report. 成人T细胞白血病/淋巴瘤引起的脑淋巴瘤病:抑郁症的鉴别诊断:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-07-31 DOI: 10.1186/s13256-024-04666-1
Satoshi Inaba, Masataka Kudo, Hironori Kamano, Yoshihiro Ohishi, Junichi Kiyasu, Takashi Watari
{"title":"Lymphomatosis cerebri caused by adult T cell leukemia/lymphoma: a differential diagnosis for depression: a case report.","authors":"Satoshi Inaba, Masataka Kudo, Hironori Kamano, Yoshihiro Ohishi, Junichi Kiyasu, Takashi Watari","doi":"10.1186/s13256-024-04666-1","DOIUrl":"10.1186/s13256-024-04666-1","url":null,"abstract":"<p><strong>Background: </strong>Primary central nervous system lymphoma is rare, and primary central nervous system T cell lymphoma is relatively uncommon, contributing to < 5% of all cases. Lymphomatosis cerebri, a rare subtype of primary central nervous system lymphoma, is characterized by extensive white-matter lesions on magnetic resonance imaging and nonspecific symptoms, such as cognitive decline and depression. Reports of lymphomatosis cerebri in adult T cell leukemia/lymphoma are limited.</p><p><strong>Case presentation: </strong>A 49-year-old Japanese man gradually developed insomnia, anorexia, and weight loss over a 2-month period following work-related promotion. Initially diagnosed with depression, his condition rapidly deteriorated with cognitive decline and motor dysfunction. Despite various treatments, his symptoms persisted within a month. Upon admission, the presence of neurological abnormalities suggestive of a central nervous system disorder raised suspicion of a cerebral lesion. Diagnostic tests revealed extensive brain lesions on imaging and the presence of atypical lymphocytes (flower cells) in the cerebrospinal fluid. The patient was diagnosed with lymphomatosis cerebri due to adult T cell leukemia/lymphoma, a rare presentation in the literature. Due to irreversible brainstem damage and poor neurological prognosis, aggressive treatment was not initiated, and the patient died, with an autopsy confirming the diagnosis.</p><p><strong>Conclusion: </strong>Lymphomatosis cerebri with adult T cell leukemia/lymphoma is very rare. It is crucial to promptly consider lymphomatosis cerebri as a differential diagnosis, particularly in cases of rapid cognitive decline and poor treatment response. Recognition of lymphomatosis cerebri as an important differential diagnosis for cognitive decline, and depression is necessary for timely intervention and management. Further research is required to better understand this unique and rare presentation in adult T cell leukemia/lymphoma.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Atypical duplex appendix arising from the ascending colon: a case report. 致编辑的信:升结肠产生的非典型盲肠:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-07-31 DOI: 10.1186/s13256-024-04687-w
B M Munasinghe
{"title":"Letter to the Editor: Atypical duplex appendix arising from the ascending colon: a case report.","authors":"B M Munasinghe","doi":"10.1186/s13256-024-04687-w","DOIUrl":"10.1186/s13256-024-04687-w","url":null,"abstract":"","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthroscopic reduction and internal fixation for fracture of the posterior process of the talus (Shepherd's fracture): a case report. 距骨后突骨折(Shepherd骨折)的关节镜复位和内固定术:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-07-30 DOI: 10.1186/s13256-024-04652-7
Branislav Krivokapic, Pieter DHooghe, Nikola Bogosavljevic, Danilo Jeremic, Nina Rajović
{"title":"Arthroscopic reduction and internal fixation for fracture of the posterior process of the talus (Shepherd's fracture): a case report.","authors":"Branislav Krivokapic, Pieter DHooghe, Nikola Bogosavljevic, Danilo Jeremic, Nina Rajović","doi":"10.1186/s13256-024-04652-7","DOIUrl":"10.1186/s13256-024-04652-7","url":null,"abstract":"<p><strong>Introduction: </strong>Fracture of the lateral tubercle of the posterior process of the talus (Shepherd fracture) is an uncommon injury seen in sport. It is secondary either to indirect trauma on the plantarflexed foot or to high-impact direct trauma. The fracture can be missed with conventional X-rays and therefore advanced imaging methods such as CT scans are usually warranted for management planning. There is a low threshold towards surgical management in the displaced or comminuted case as the delayed functional outcome with conservative treatment is frequently sub-optimal with long-term pain, degenerative changes and non-union. In this regard, recent years saw an increasing interest in the role of minimally invasive approaches for Shepherd´s fracture treatment, such as arthroscopic reduction and internal fixation (ARIF).</p><p><strong>Case report: </strong>We present a case of a 27-year-old white male professional football player from Serbia who had Shepard fracture and successfully managed with arthroscopic osteosynthesis. The technical approach is detailed with posterior ankle arthroscopy offering the advantages of a minimally invasive approach with low morbidity and a rapid return to regular sporting activities.</p><p><strong>Conclusion: </strong>The utilization of the 2-port arthroscopic approach this method enables the direct observation of the articular surface along with the corresponding fracture lines, thereby affording the surgeon the chance to achieve accurate reduction via a minimally invasive soft tissue aperture. We advocate that Arthroscopic reduction and internal fixation (ARIF) is a reliable method for the fixation of Shepherd's fracture in the hands of experienced ankle arthroscopists.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preserved walking function without postoperative reconstruction for pelvic Ewing's sarcoma: a case report. 盆腔尤文氏肉瘤术后重建无需保留行走功能:病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2024-07-29 DOI: 10.1186/s13256-024-04670-5
Kazunori Nakayama, Seiji Shimomura, Toshiharu Shirai, Ryu Terauchi, Naoki Mizoshiri, Yuki Mori, Tomoki Saito, Yusei Katsuyama, Shinji Tsuchida, Kenji Takahashi
{"title":"Preserved walking function without postoperative reconstruction for pelvic Ewing's sarcoma: a case report.","authors":"Kazunori Nakayama, Seiji Shimomura, Toshiharu Shirai, Ryu Terauchi, Naoki Mizoshiri, Yuki Mori, Tomoki Saito, Yusei Katsuyama, Shinji Tsuchida, Kenji Takahashi","doi":"10.1186/s13256-024-04670-5","DOIUrl":"10.1186/s13256-024-04670-5","url":null,"abstract":"<p><strong>Background: </strong>Ewing's sarcoma is a primary bone tumor predominantly observed in children and adolescents, necessitating a multidisciplinary treatment approach. While localized cases have a 5-year survival rate of 60-70%, the prognosis is significantly worse in pelvic advanced cases with metastasis. Moreover, pelvic Ewing's sarcoma has the unique problem of leading to high rates of postoperative infection.</p><p><strong>Case presentation: </strong>We present the case of a Japanese 14-year-old boy with left iliac Ewing's sarcoma and multiple metastases. At the initial visit, imaging revealed a large tumor in the left iliac bone with extraosseous extension and metastasis to multiple sites. Neoadjuvant chemotherapy resulted in significant tumor reduction. Surgical resection was performed without pelvic ring reconstruction to enable early postoperative chemotherapy and minimize postoperative infection risk. Despite complete abductor muscle removal, the patient achieved a stable gait postoperatively by centering the load axis.</p><p><strong>Conclusion: </strong>Our case highlights the successful management of a left iliac Ewing's sarcoma with multiple metastases, with a focus on functional preservation and infection risk reduction. Pelvic ring reconstruction was not performed to avoid postoperative complications, emphasizing the importance of early postoperative chemotherapy. The patient achieved a stable gait postoperatively, demonstrating the potential benefits of this approach in similar cases.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stevens–Johnson syndrome-toxic epidermal necrolysis overlap in a patient taking quetiapine and famotidine: a case report 一名服用喹硫平和法莫替丁的患者出现史蒂文斯-约翰逊综合征--中毒性表皮坏死:病例报告
IF 1
Journal of Medical Case Reports Pub Date : 2024-07-28 DOI: 10.1186/s13256-024-04629-6
Chi-Sheng Su, Chi-Lan Kao
{"title":"Stevens–Johnson syndrome-toxic epidermal necrolysis overlap in a patient taking quetiapine and famotidine: a case report","authors":"Chi-Sheng Su, Chi-Lan Kao","doi":"10.1186/s13256-024-04629-6","DOIUrl":"https://doi.org/10.1186/s13256-024-04629-6","url":null,"abstract":"Stevens–Johnson syndrome-toxic epidermal necrolysis (SJS-TNE) overlap is a rare skin disorder characterized by erythema, blisters, extensive exfoliation, epidermal detachment, the involvement of multiple mucosae, and positive Nikolsky’s sign. SJS-TEN has a high mortality rate. Our case involves a rare occurrence of drug-induced Stevens–Johnson syndrome-toxic epidermal necrolysis overlap with a delayed onset in the setting of quetiapine and famotidine therapy. An 82-year-old Taiwanese female was admitted to our hospital for decreased urine output, generalized edema, and multiple skin blisters and bedsores. With further spread of the lesions, multiple ruptured bullae with shallow erosions on the face, trunk, and limbs and mucosal involvement affected 20% of the total body surface area. Nikolsky’s sign was positive. A diagnosis of Steven–Johnson syndrome was highly suspected. One month prior, she had started famotidine and quetiapine. Intravenous methylprednisolone treatment was initiated, which ameliorated the skin lesions after 3 days. However, new lesions developed after only 1 day of methylprednisolone tapering. The patient died 12 days after admission. Stevens–Johnson syndrome-toxic epidermal necrolysis is a rare skin disorder. Although it is mainly acute and has a high mortality rate, delayed onset can still occur. Quetiapine and famotidine are generally safe and effective for treating geriatric and gastrointestinal problems, but rare drug hypersensitivity reactions can lead to debilitating consequences. Therefore, increased clinical awareness and the initiation of supportive care are imperative. Optimal management guidelines are still lacking, and confirmation of developed guidelines through randomized controlled trials is needed. Collaboration for better management strategies is warranted.","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141771016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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