Journal of Medical Case Reports最新文献

{"title":"A fast and easy-to-perform noninvasive Muller's muscle sublimation technique using plasma technology for treatment of mild-to-moderate ptosis: a case report.","authors":"Nasrin Raffati","doi":"10.1186/s13256-025-05330-y","DOIUrl":"10.1186/s13256-025-05330-y","url":null,"abstract":"<p><strong>Background: </strong>Currently, most surgeons favor Muller's muscle conjunctival resection as a treatment for mild-to-moderate ptosis, as this method is associated with fewer post-surgical complications.</p><p><strong>Case presentation: </strong>This case series of six Iranian women aged between 15 and 65 (mean 43) years with mild-to-moderate ptosis treated at Negah Eye Hospital used a plasma scalpel (PLEXR™) for conjunctivo-Muller sublimation. A 1-4 area management strategy was applied, and margin reflex distance 1 measurements showed improvement from 1.58 mm pre-treatment to 3.66 mm after 6 months.</p><p><strong>Conclusion: </strong>Seemingly, applying plasma technology to treat mild-to-moderate ptosis via conjunctivo-Muller muscle sublimation might be a promising alternative to more invasive surgical methods.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"279"},"PeriodicalIF":0.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of meglumine antimoniate in patient with cutaneous leishmaniasis with end-stage renal failure undergoing hemodialysis: a case report.","authors":"Hazem Arab, Yousef Alsaffaf, Ahmed Aldolly, Abdullah Dukhan, Thaer Douri","doi":"10.1186/s13256-025-05331-x","DOIUrl":"10.1186/s13256-025-05331-x","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous leishmaniasis is the most common form of leishmaniasis. Meglumine antimoniate is the first line of available treatment in developing countries. There is limited research on the renal effects of antimonial compounds.</p><p><strong>Case presentation: </strong>A 25-year-old Arab male patient presented to the dermatology clinic with a 9-month history of multiple skin lesions. The patient had a history of end-stage renal failure. Physical examination of these lesions revealed ulcerated nodules that are painless and non-itchy located on the hands, forearms, feet, and neck. The lesions were diagnosed as cutaneous leishmaniasis tropica on the basis of the histopathology of a skin biopsy and the patient's region, which is endemic to female sandflies and this specific subtype cutaneous leishmaniasis. The patient started taking meglumine antimoniate intramuscular administration after the dialysis session at a dose of 750 mg/kg per week. The lesions showed partial to complete remission after 60 days of treatment without any meglumine antimoniate side effects. The patient has not experienced any relapse of leishmaniasis since kidney transplantation 6 years ago.</p><p><strong>Conclusion: </strong>This case highlights knowledge gaps in the therapeutic approach for using meglumine antimoniate in patients with end-stage renal failure undergoing hemodialysis. The need for further research and clinical trials to establish clear guidelines is essential.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"277"},"PeriodicalIF":0.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoidal hypertrophy and pulmonary bullae in a child: a case report.","authors":"Lei Ding, Hui Jiang","doi":"10.1186/s13256-025-05339-3","DOIUrl":"10.1186/s13256-025-05339-3","url":null,"abstract":"<p><strong>Background: </strong>This case demonstrates the critical importance of preoperative imaging in pediatric surgery after incidentally detecting a giant pulmonary bulla (3.6 cm) in a Han Chinese child scheduled for routine adenoidectomy. The novelty lies in managing conflicting pathologies-common adenoidal hypertrophy versus rare asymptomatic lung anomalies-requiring multidisciplinary risk-benefit evaluation.</p><p><strong>Case presentation: </strong>A previously healthy Han Chinese 6-year-old boy was admitted for adenoidectomy using plasma radiofrequency ablation. Preoperative chest radiograph and computed tomography unexpectedly revealed a right lung bulla. Despite meeting surgical criteria for adenoid hypertrophy, the procedure was cancelled owing to anesthesia-related barotrauma risks. A joint decision involving parents, surgeons, and anesthesiologists prioritized conservative management, with nasal steroids for adenoids and monitoring for the bulla.</p><p><strong>Conclusion: </strong>This case highlights the importance of preoperative thoracic imaging in children undergoing elective surgery, particularly in those of Han Chinese ethnicity, to detect occult anomalies. The incidental finding of a giant pulmonary bulla necessitated a multidisciplinary approach and transparent parent-clinician collaboration, leading to a conservative management strategy. The decision to defer surgery in favor of monitoring underscores the need for individualized risk assessment and patient-centered care in pediatric surgical practice.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"276"},"PeriodicalIF":0.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic gastroenteritis in a 14-year-old patient with Noonan syndrome with a PTPN11 variation: a case report.","authors":"Nobuhiko Koga, Shuichi Yatsuga, Kei Kubota, Toshikazu Niimi, Takahito Inoue, Shinichiro Nagamitsu","doi":"10.1186/s13256-025-05344-6","DOIUrl":"10.1186/s13256-025-05344-6","url":null,"abstract":"<p><strong>Background: </strong>Noonan syndrome has a wide range of symptoms due to dysregulation of the RAS/MAPK pathway with several gene variations, including the PTPN11 gene. There are currently no case reports of Noonan syndrome with eosinophilic gastroenteritis.</p><p><strong>Case: </strong>A 14-year-old Japanese girl was clinically diagnosed with Noonan syndrome. She had intermittent abdominal pain and vomiting from 10 years old. The patient was diagnosed with eosinophilic gastroenteritis on the basis of the pathological finding of multiple foci with > 20 eosinophils/high power field in the mucosal lamina propria of the colon by endoscopy at 12 years old. Vomiting and abdominal pain are currently being controlled by antihistamines and leukotriene antagonist therapy. Genetic testing showed the missense variation p.Ala72Gly in the PTPN11 gene.</p><p><strong>Discussion: </strong>The pathogenesis of eosinophilic gastroenteritis is similar to that of other allergic inflammatory diseases, such as bronchial asthma. The cause of eosinophilic gastroenteritis is multifactorial, including genetic and environmental factors. The PTPN11 gene variations are suggested to promote eosinophilic disorders by leading to the activation of the RAS/MAPK pathway. This activation subsequently results in the production of interleukin-5, which plays a crucial role in the pathogenesis of eosinophilic gastroenteritis. The relationship between eosinophilic gastroenteritis and the PTPN11 gene has not yet been reported.</p><p><strong>Conclusion: </strong>We herein present the first known case of eosinophilic gastroenteritis in Noonan syndrome with a variation in the PTPN11 gene. The relationship between Noonan syndrome and eosinophilic gastroenteritis remains unknown; therefore, additional case reports of Noonan syndrome with eosinophilic gastroenteritis are required to elucidate this potential relationship.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"273"},"PeriodicalIF":0.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent symmetrical white matter hyperintensities: a case report.","authors":"S A Paranavitane, P Manokaran, N T Wijesinghe, S Bandusena, A Fernando","doi":"10.1186/s13256-025-05342-8","DOIUrl":"10.1186/s13256-025-05342-8","url":null,"abstract":"<p><strong>Introduction: </strong>White matter hyperintensities on magnetic resonance imaging are a frequent finding. Anaplastic astrocytoma as a cause of persistent, symmetrical white matter hyperintensities is unusual.</p><p><strong>Case presentation: </strong>A 22-year-old Sri Lankan male presented with an episodic, nonspecific headache for 1 month's duration, which was followed by brief episodes of altered awareness and a progressive decrease in consciousness. The physical examination showed a reduced conscious state without any focal neurological signs. Non-contrast computed tomography brain showed cerebral edema and dilated temporal horns of the lateral ventricles. Magnetic resonance imaging of the brain showed extensive, symmetrical T2 and fluid-attenuated inversion recovery hyperintensities involving the corpus callosum, pericallosal region, periventricular white matter, deep white matter, and bilateral cerebellar hemispheres surrounding the dentate nuclei, without diffusion restriction or contrast enhancement. In addition, the body of the lateral ventricles were compressed leading to dilatation of the temporal horns. The cerebrospinal fluid full report was normal, and the cerebrospinal fluid cultures and cytology was negative. External ventricular drainage was placed after consultation with the neurosurgeons. He was treated with intravenous 3% sodium chloride for a few days and intravenous dexamethasone, intravenous ceftriaxone, and intravenous acyclovir for 14 days. There was no significant clinical or radiological improvement. A ventricular wall biopsy was performed. This showed an anaplastic astrocytoma (World Health Organization Grade III). The patient was subsequently referred for specialized oncological management, but died following the initiation of chemotherapy.</p><p><strong>Conclusion: </strong>This case highlights the unusual presentation of a primary central nervous system tumor with symmetrical, persistent white matter hyperintensities.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"275"},"PeriodicalIF":0.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-melanoma differentiation-associated gene 5 antibody associated rapidly progressive interstitial lung disease in a pediatric patient: a case report.","authors":"Thitima Sirimontakan, Natalia Escobar, Fiona Kritzinger, Elizaveta Limenis, Greta Mastrangelo, Briseida Mema, Haifa Mtaweh","doi":"10.1186/s13256-025-05336-6","DOIUrl":"10.1186/s13256-025-05336-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Rapidly progressive interstitial lung disease presents as a severe complication of juvenile dermatomyositis, particularly when associated with anti-melanoma differentiation-associated gene 5. We report a pediatric case that underscores the necessity for clinicians to maintain a high index of suspicion for early identification and management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case presentation: &lt;/strong&gt;A previously healthy 7-year-old White girl presented with a 6-week history of generalized weakness, fever, joint pain, and abdominal pain. Initial examination revealed hypoxia, tachypnea, and hepatosplenomegaly. Laboratory tests were marked by thrombocytopenia, lymphopenia, elevated liver enzymes, high ferritin, high triglyceride, elevated muscle enzymes, and increased soluble IL-2 receptor, suggesting macrophage activation syndrome that was and managed with dexamethasone 5 mg/kg/m&lt;sup&gt;2&lt;/sup&gt; twice daily. There were no pathogenic skin features of juvenile dermatomyositis, except for nailfold capillary dropout. Initial cell counts revealed that her white blood cell count was 2.87 × 10&lt;sup&gt;9&lt;/sup&gt;/L, hemoglobin was 105 g/L, platelet was 90 × 10&lt;sup&gt;9&lt;/sup&gt;/L, and ferritin was 2000.6 μg/L and antinuclear and anti-Ro52 antibodies were positive. She was noted to have peripheral muscle weakness. Her clinical course was marked by progressive respiratory failure requiring mechanical ventilation with imaging revealing diffuse alveolar ground-glass opacities. The infectious work up was negative for bacterial, fungal, and viral ethologies including Epstein-Barr virus; hepatitis A virus, hepatitis B, hepatitis C, and hepatitis E viruses; parvovirus B19; cytomegalovirus; herpes simplex virus 1 and 2; and human herpesvirus 6. With the interstitial lung disease picture, pulse doses of intravenous methylprednisolone and intravenous immunoglobulin were initiated. She developed a significant air leak that was managed with bilateral chest tubes. Her significant hypoxemia required cannulation to veno-venous extracorporeal membrane oxygenation. The diagnosis of anti-melanoma differentiation-associated gene 5 antibody-associated juvenile dermatomyositis was confirmed by antibody testing. Additional immunomodulatory therapy was utilized during the treatment course with no noted improvement. She was not a candidate for lung transplantation, and in the face of additional organ dysfunction, life-sustaining therapies were withdrawn on day 32 of intensive care unit admission.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This case demonstrates the diagnostic and therapeutic challenges in patients with rapidly progressive interstitial lung disease in the context of anti-melanoma differentiation-associated gene 5 associated juvenile dermatomyositis, who may not present with overt muscle and cutaneous features of juvenile dermatomyositis and whose lung disease can progress very rapidly. A high index of suspicion among clinicians is critical, and expedited diagnostic serology ","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"274"},"PeriodicalIF":0.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of a patient with renal tubular acidosis: renal tubular acidosis with hyperparathyroidism, pheochromocytoma, and multiple kidney stones: a case report.","authors":"Marzieh Nasiri Sangari, Reza Salehinia, Hossein Rahnama, Fatemeh Ameri, Arefeh Azimi Athary, Farnaz Lashgari","doi":"10.1186/s13256-025-05343-7","DOIUrl":"10.1186/s13256-025-05343-7","url":null,"abstract":"<p><strong>Background: </strong>Renal tubular acidosis is a rare disorder affecting acid-base balance, and its coexistence with endocrine abnormalities such as hyperparathyroidism and pheochromocytoma is exceptionally uncommon. This combination presents unique diagnostic and therapeutic challenges requiring a multidisciplinary approach.</p><p><strong>Case presentation: </strong>A 25-year-old Iranian woman presented with recurrent flank pain, episodic palpitations, headaches, and intermittent hypertension. Imaging revealed bilateral nephrolithiasis, leading to ureteroscopic lithotripsy. Biochemical evaluation confirmed distal renal tubular acidosis (type 1), hyperparathyroidism, and pheochromocytoma, a rare and complex association. Metabolic acidosis, hypokalemia, and elevated catecholamine metabolites were noted. Potassium citrate was prescribed for stone prevention, and the patient remains asymptomatic after a year of follow-up.</p><p><strong>Conclusion: </strong>This case underscores the need for heightened clinical suspicion when nephrolithiasis is accompanied by systemic symptoms. The rare coexistence of renal tubular acidosis, hyperparathyroidism, and pheochromocytoma highlights the importance of early recognition and a multidisciplinary approach to prevent complications and optimize patient outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"272"},"PeriodicalIF":0.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5q deletion in childhood T-acute lymphoblastic leukemia at diagnosis: a case report.","authors":"Yousra Sbibih, Mohammed Bensalah, Mounia Slaoui, Abderrazak Saddari, Nabiha Trougouty, Abdelilah Berhili, Rachid Seddik","doi":"10.1186/s13256-024-04999-x","DOIUrl":"10.1186/s13256-024-04999-x","url":null,"abstract":"<p><strong>Background: </strong>We present the case of a 6-year-old Moroccan male patient of Berber ethnic origin, diagnosed with T-cell acute lymphoblastic leukemia, who exhibited a deletion of the 5q region.</p><p><strong>Case presentation: </strong>The patient initially presented with classic symptoms of T-cell acute lymphoblastic leukemia, including bone pain, hepatosplenomegaly, and lymphadenopathy. Laboratory tests revealed anemia, hyperleukocytosis, and a high percentage of lymphoid blasts in both the blood and bone marrow. Immunophenotyping results confirmed that these blasts were of T-cell origin. Cytogenetic analysis identified a deletion of the long arm of chromosome 5 in a subset of the patient's cells.</p><p><strong>Conclusion: </strong>The presence of a 5q deletion in pediatric T-cell acute lymphoblastic leukemia is an unusual finding and its prognostic significance may differ from that observed in myeloid leukemias. The implications of this cytogenetic anomaly in lymphoid malignancies remain unclear and warrant further investigation. Understanding the origins and effects of such chromosomal abnormalities in T-cell acute lymphoblastic leukemia could provide deeper insights into the disease's pathogenesis and contribute to more tailored therapeutic strategies.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"271"},"PeriodicalIF":0.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric pneumatosis and hepatoportal venous gas in superior mesenteric artery syndrome: a case report.","authors":"Elie Ghadban, Seba Mhanna, Cesar Ghadbane, Bassem Akiki, Georgio El-Joukhadar, Saade Abboud","doi":"10.1186/s13256-025-05093-6","DOIUrl":"10.1186/s13256-025-05093-6","url":null,"abstract":"<p><strong>Background: </strong>Gastric pneumatosis is a rare condition characterized by the presence of air within the stomach wall. It can range from benign conditions to potentially fatal complications. It can be classified as gastric emphysema or emphysematous gastritis. Hepatic portal venous gas, which is often linked to high mortality rates, presents a controversial decision regarding the necessity of surgical intervention. This rare case of gastric pneumatosis and hepatic portal venous gas is notable for its association with superior mesenteric artery syndrome, an uncommon underlying cause, and highlights the potential for a benign outcome despite alarming initial signs.</p><p><strong>Case presentation: </strong>This is a case of an 87-year-old Lebanese Middle Eastern female patient who presented with diffuse abdominal pain and severe postprandial vomiting, which showed gastric emphysema and hepatoportal venous gas due to superior mesenteric artery syndrome upon investigation. While worrisome findings on radiological imaging and gastric endoscopy favor urgent surgical intervention, this patient was managed conservatively with successful outcomes before proceeding to surgery to treat the atypical underlying causative superior mesenteric artery syndrome. Endoscopic images illustrate the dramatic initial presentation and unexpected clinical improvement, highlighting the unique aspects of this case.</p><p><strong>Conclusion: </strong>This case highlights the rare occurrence of gastric pneumatosis with hepatic portal venous gas linked to superior mesenteric artery syndrome and highlights both the severity of initial symptoms and their benign resolution, focusing on the unexpected clinical variability of superior mesenteric artery syndrome. These findings suggest that conservative management can lead to favorable outcomes, challenging the typical urgency for surgical intervention in such alarming cases. The overall clinical picture, including the underlying etiology, clinical examination, and laboratory parameters should be considered when making treatment decisions.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"270"},"PeriodicalIF":0.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilobar massive cavitating adenocarcinoma: a case report.","authors":"Gerardo Arwi, Paul Fogarty, Andrew Mant, Julee H'ng, Andrew Barling, Francis Thien","doi":"10.1186/s13256-025-05140-2","DOIUrl":"10.1186/s13256-025-05140-2","url":null,"abstract":"<p><strong>Background: </strong>The diagnostic evaluation of complex cavitary lung lesions is often challenging owing to the broad spectrum of differential diagnoses. These lesions can be associated with various conditions, making it crucial to employ comprehensive diagnostic strategies. This case underscores the significance of serial imaging, close clinical follow-up, and surgical biopsy in managing such complex cases.</p><p><strong>Case presentation: </strong>A 59-year-old woman of Indian descent was referred for the management of pneumonia. Initial chest computed tomography showed patchy inflammatory changes in the right upper lobe, a large cavity in the left upper lobe, and a smaller cavity in the left lower lobe. Follow-up imaging indicated progressive cavitary disease. Bronchoscopies did not yield significant findings. A video-assisted thoracoscopic surgery biopsy was performed, which confirmed mucinous adenocarcinoma.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic challenge posed by cavitary lung lesions and emphasizes the importance of serial imaging, vigilant clinical monitoring, and surgical biopsy in achieving an accurate diagnosis. Early and systematic investigation is key to identifying rare causes such as mucinous adenocarcinoma.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"269"},"PeriodicalIF":0.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}