{"title":"Langerhans cell histiocytosis present in a 1-day-old girl: a case report.","authors":"Yang Meng","doi":"10.1186/s13256-025-05485-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis is a rare condition characterized by diverse clinical manifestations, ranging from cutaneous lesions to systemic involvement. Although Langerhans cell histiocytosis occurs infrequently in newborns, its diagnosis during this period presents significant challenges.</p><p><strong>Case presentation: </strong>A 1-day-old Chinese female infant presented with multiple red papules at birth and was diagnosed with Langerhans cell histiocytosis following a second skin biopsy. Despite symptomatic treatment, the child experienced recurrent fever and gastrointestinal bleeding. Tafinlar treatment was initiated at 2 months of age, which improved her symptoms.</p><p><strong>Conclusion: </strong>Prompt identification of Langerhans cell histiocytosis in newborns remains challenging owing to the disease's complexity and varied clinical manifestations; thus, it is essential to advance pathological technologies for Langerhans cell histiocytosis detection.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"406"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357455/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13256-025-05485-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Background: Langerhans cell histiocytosis is a rare condition characterized by diverse clinical manifestations, ranging from cutaneous lesions to systemic involvement. Although Langerhans cell histiocytosis occurs infrequently in newborns, its diagnosis during this period presents significant challenges.
Case presentation: A 1-day-old Chinese female infant presented with multiple red papules at birth and was diagnosed with Langerhans cell histiocytosis following a second skin biopsy. Despite symptomatic treatment, the child experienced recurrent fever and gastrointestinal bleeding. Tafinlar treatment was initiated at 2 months of age, which improved her symptoms.
Conclusion: Prompt identification of Langerhans cell histiocytosis in newborns remains challenging owing to the disease's complexity and varied clinical manifestations; thus, it is essential to advance pathological technologies for Langerhans cell histiocytosis detection.
期刊介绍：
JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
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