Journal of Medical Case Reports最新文献

{"title":"Eosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report.","authors":"Sarah Jalloul, Johny Salem, Karam Karam, Clara Chamoun, Louis Chaptini","doi":"10.1186/s13256-025-05044-1","DOIUrl":"10.1186/s13256-025-05044-1","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic esophagitis is a condition characterized clinically by symptoms related to esophageal dysfunction and histologically by a marked eosinophilic infiltrate in the esophageal mucosa. The most typical symptoms of eosinophilic esophagitis include intermittent dysphagia with episodic food impaction and heartburn with propensity for young individuals. The relationship between hiccups and eosinophilic esophagitis is unclear but has been described.</p><p><strong>Case report: </strong>We report a case of a 93-year-old Middle Eastern male presenting for longstanding treatment-refractory hiccups. Imaging with computed tomography of the chest and abdomen was unremarkable. An upper endoscopy was normal without any endoscopic finding to suggest eosinophilic esophagitis. Given his elevated peripheral eosinophil count, biopsies were taken from mid- and distal esophagus and revealed eosinophilic infiltration in the range of 15 eosinophils per high-power field, favoring a diagnosis of eosinophilic esophagitis. The hiccups resolved following the initiation of eosinophilic esophagitis treatment.</p><p><strong>Conclusion: </strong>This case underscores the need to consider the diagnosis of eosinophilic esophagitis in the setting of chronic refractory hiccups.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"99"},"PeriodicalIF":0.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The novel SERPINC1 missense mutation c.1148 T > A (p.L383H) causes hereditary antithrombin deficiency and thromboembolism in a Chinese family: a case report.","authors":"Fangkai He, Yang Wang, Weiwei Ning, Chao Liu, Xiaojun Guan, Yao Yao","doi":"10.1186/s13256-025-05114-4","DOIUrl":"https://doi.org/10.1186/s13256-025-05114-4","url":null,"abstract":"<p><strong>Background: </strong>Hereditary antithrombin deficiency, an autosomal-dominant thrombotic disease caused by a SERPINC1 gene deficiency, is extremely rare, although it is the leading cause of hereditary thrombophilias. Herein we report a novel SERPINC1 gene mutation in a Chinese family and one case of pulmonary embolism associated with the mutation. We also discuss the latest diagnostic and treatment strategies for antithrombin deficiency.</p><p><strong>Case presentation: </strong>The 33-year-old Chinese male proband had a pulmonary embolism and there was no evidence of thromboembolism in the other family members. In the pulmonary embolism case, treatment with nadroparin calcium combined with warfarin failed; however, rivaroxaban was effective. No emboli were evident in the follow-up computed tomography pulmonary angiography. Antithrombin activity fluctuated approximately 50% during hospitalization and follow-up. The antithrombin activity of the proband, his 58-year-old father, and his 5-year-old son was significantly low (44-48%). A novel missense variant c.1148 T > A (p.L383H) in the SERPINC1 gene was identified in these three family members. The pathogenesis predictions from Mutation-Taster, Provean, and SIFT were \"disease-causing,\" \"deleterious,\" and \"damaging,\" respectively.</p><p><strong>Conclusion: </strong>The novel c.1148 T > A (p.L383H) pathogenic mutation in the SERPINC1 gene updated the gene mutation spectrum of hereditary antithrombin deficiency. Direct oral anticoagulation with rivaroxaban may be a more effective and selective anticoagulant in patients with hereditary antithrombin deficiency over warfarin or heparin.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"102"},"PeriodicalIF":0.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of two previously unreported Duchenne muscular dystrophy gene variants in a patient diagnosed with a dystrophinopathy: a case report.","authors":"Sarah Gerges, Rania Naoufal, Hicham Mansour","doi":"10.1186/s13256-025-05135-z","DOIUrl":"https://doi.org/10.1186/s13256-025-05135-z","url":null,"abstract":"<p><strong>Introduction: </strong>Duchenne muscular dystrophy and Becker muscular dystrophy are X-linked recessive disorders affecting muscle function, which are caused by mutations in the dystrophin gene (also known as the Duchenne muscular dystrophy gene). The resulting condition is dictated by the severity of the involved mutation; for instance, Duchenne muscular dystrophy presents in early childhood with rapid progression, whereas Becker muscular dystrophy exhibits a milder, later onset with slower progression. In this report, we present the case of a young patient with clinical symptoms of a dystrophinopathy, whose genetic analysis yielded two previously undescribed mutations within the dystrophin gene.</p><p><strong>Case presentation: </strong>This paper focuses on a 12-year-old Syrian male patient with a 6-year history of progressive gait difficulty, lower limb weakness, and recurrent falls. Physical examination revealed a positive Gowers' sign and pseudohypertrophy, but normal muscle strength. A diagnosis of myopathy was supported by elevated serum creatine kinase and a muscle biopsy showing dystrophic changes in the right quadriceps muscle. While the initial deletion and duplication screening in the Duchenne muscular dystrophy gene using multiplex ligation-dependent probe amplification was negative, further extensive genetic analysis revealed two novel hemizygous variants of uncertain significance in the Duchenne muscular dystrophy gene (c.536A > T p.(Asp179Val) and c.680C > T p.(Ser227Phe), with no other clinically relevant variants in the neuromuscular panel.</p><p><strong>Conclusion: </strong>The identification of novel variants in the Duchenne muscular dystrophy gene, alongside the absence of pathogenic mutations in other genes investigated by the neuromuscular panel, strongly suggests an X-linked dystrophinopathy diagnosis in our patient. This case highlights the need for continued exploration of dystrophinopathies' genetic variants. Further studies are required to elucidate the functional impact of these novel variants and to improve our understanding of the genotypic and phenotypic variability observed in these disorders, which may lead to a revolution in treatment approaches and potentially offer curative options for patients.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"101"},"PeriodicalIF":0.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report.","authors":"Xianshu Liu, Ailian Sun, Xingxing Zheng, Meng Xia, Yan Liu, Shuaiqin Huang, Xiang Wu","doi":"10.1186/s13256-025-05105-5","DOIUrl":"10.1186/s13256-025-05105-5","url":null,"abstract":"<p><strong>Background: </strong>Hookworm infection remains of considerable importance to public health. However, because critical cases caused by hookworm infection are rarely observed in China, accurate and prompt diagnoses are difficult to achieve in clinical practice. In this study, we describe how we combined morphological and molecular approaches to achieve the clinical diagnosis of hookworm infection.</p><p><strong>Case presentation: </strong>A 75-year-old Chinese woman who presented with dizziness, poor appetite, poor sleep, and weakness in her limbs was diagnosed with chronic atrophic gastritis and was positive for Helicobacter pylori, iron deficiency anemia with a hemoglobin concentration of 35 g/L, and left atrial enlargement. However, after symptomatic treatment, the patient did not improve. Upper gastrointestinal endoscopy revealed the presence of live nematodes in the descending portion of the patient's duodenum. Fecal examination via saturated brine flotation revealed hookworm eggs. Further verification via semi-nested reverse transcription-polymerase chain reaction assay confirmed provided confirmation that the hookworm species was Necator americanus. Albendazole was used for antihelminthic treatment. Through follow-up visits, we found that the antihelminthic treatment was successful and that her anemia was cured.</p><p><strong>Conclusion: </strong>In this study, a combination of morphological and molecular approaches were used to make a definite diagnosis of severe iron deficiency anemia caused by Necator americanus infection in a patient. The results presented here provide suitable guidance for the clinical diagnosis of hookworm infection and a powerful tool for the identification of hookworms.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"100"},"PeriodicalIF":0.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pancreatitis as an initial presentation of systemic lupus erythematosus: a case report.","authors":"Mengyu Li, Sutong Li","doi":"10.1186/s13256-025-05119-z","DOIUrl":"10.1186/s13256-025-05119-z","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus is a systemic autoimmune disease affecting different organ systems. Gastrointestinal symptoms in patients with systemic lupus erythematosus are common. But systemic lupus erythematosus-related acute pancreatitis is a rare presentation. Particularly, it is extremely rare to observe acute pancreatitis as the initial presentation of systemic lupus erythematosus combined with antiphospholipid syndrome.</p><p><strong>Case presentation: </strong>Here, we report a case of abdominal pain as the initial symptom of systemic lupus erythematosus in a patient who was finally diagnosed with systemic lupus erythematosus-related acute pancreatitis. Our patient was a 47-year-old Han female with epigastric pain, nausea, vomiting gastric contents, and loss of appetite. She did not mention any relevant medical history and did not consume alcohol nor greasy food. She was successively diagnosed with acute cholecystitis, acute pancreatitis, and acute appendicitis, but relevant therapeutic interventions proved to be ineffective in improving gastrointestinal symptoms. Renal pathology, along with positive antinuclear antibody and anti-double stranded DNA tests, supported the diagnosis of systemic lupus erythematosus. In addition, the presence of positive anti-cardiolipin antibodies and lupus anti-coagulant, along with thrombosis in vein and internal carotid artery occlusion, supported the diagnosis of antiphospholipid syndrome. Corticosteroid and cyclophosphamide therapy led to resolution of abdominal manifestations, and the patient was discharged with methylprednisolone and hydroxychloroquine. Aspirin was used to treat antiphospholipid syndrome.</p><p><strong>Conclusion: </strong>Systemic lupus erythematosus-related acute pancreatitis should be considered in the differential diagnosis of patients with acute pancreatitis after exclusion of other causes. The patient was given treatment as soon as possible. Corticosteroids combined with cyclophosphamide are an effective treatment.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"95"},"PeriodicalIF":0.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudocyclops lesion treated conservatively: a case report.","authors":"Seela Hinrichs, Rich Snellings, Ryan Scholte","doi":"10.1186/s13256-025-05025-4","DOIUrl":"10.1186/s13256-025-05025-4","url":null,"abstract":"<p><strong>Background: </strong>This case report explores the rare complication of a pseudocyclops lesion within an anterior cruciate ligament autograft, identified in a patient with a recent knee injury and an existing anterior cruciate ligament autograft graft. Notably, this case was managed conservatively, diverging from typical surgical interventions, and resulted in a successful outcome.</p><p><strong>Case presentation: </strong>A 37-year-old Caucasian male with a prior anterior cruciate ligament autograft sustained a new knee injury; 9 days post-injury, he presented with persistent pain and swelling, exacerbated by weight-bearing, and limited knee extension, though no instability was noted. Non-contrast magnetic resonance imaging revealed a partial tear in the distal anterior fibers of the anterior cruciate ligament autograft, with a 2.5 × 1.3 cm extrusion extending toward Hoffa's fat pad. The patient was prescribed nonsurgical rehabilitation, which proved effective.</p><p><strong>Conclusions: </strong>This case underscores the potential of conservative management for pseudocyclops lesions. The successful non-surgical treatment of the pseudocyclops lesion expands the therapeutic options available for similar cases and contributes to the broader understanding of postoperative anterior cruciate ligament autograft pathologies.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"97"},"PeriodicalIF":0.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent-induced hypersensitivity leading to refractory in-stent restenosis: a case report.","authors":"Menghuai Ma, Jiong Tang","doi":"10.1186/s13256-025-05122-4","DOIUrl":"10.1186/s13256-025-05122-4","url":null,"abstract":"<p><strong>Background: </strong>Even in the era of new-generation drug-eluting stents, in-stent restenosis remains a common and challenging problem of percutaneous coronary intervention. Among the many factors that contribute to in-stent restenosis, stent-related hypersensitivity is relatively rare, but may be a significant trigger of chronic refractory in-stent restenosis. Nevertheless, it is difficult to diagnose and assess the stent-related hypersensitivity, and there is no standardized treatment strategy.</p><p><strong>Case presentation: </strong>We present the case of a 63-year-old Chinese female who experienced refractory in-stent restenosis following the successful implantation of platinum chromium everolimus-eluting stents in the left main, left anterior descending and left circumflex artery. Although the cardiovascular risk factors were well-controlled, the patient developed four episodes of acute myocardial infarction with in-stent restenosis within 1 year. Intravascular ultrasound revealed diffuse neointimal hyperplasia in the in-stent restenosis lesion, and the blood tests showed no sign of systemic inflammation or infection. Thus, we speculated that the cause of refractory in-stent restenosis was stent-mediated hypersensitivity. Initially, the in-stent restenosis was treated with paclitaxel-coated balloon angioplasty, and only mild neointimal hyperplasia was observed on intravascular ultrasound 3 months after paclitaxel-coated balloon angioplasty. However, the paclitaxel-coated balloon could not prevent in-stent restenosis recurrence, and she eventually underwent coronary artery bypass grafting. After over 2 years of follow-up, her cardiac function had significantly improved, and the bridging vessels remained patent, as confirmed by computed tomography angiography.</p><p><strong>Conclusion: </strong>When encountering refractory in-stent restenosis, physicians should consider the potential for stent-associated hypersensitivity. Since there may be difficulty in obtaining histopathological examination of restenotic vessels, intravascular imaging can be instrumental in detecting neointimal hyperplasia and diagnosing stent allergy. Coronary artery bypass grafting may be a reasonable treatment for patients with stent allergy; further clinical research is required to explore the optimal treatments.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"96"},"PeriodicalIF":0.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report.","authors":"Yuksel Dogan, Adnan Mesut Dede, Arzu Erdoğan","doi":"10.1186/s13256-025-05133-1","DOIUrl":"10.1186/s13256-025-05133-1","url":null,"abstract":"<p><strong>Background: </strong>Gastric xanthelasma is a rare, benign lesion with uncertain clinical significance. Despite its asymptomatic nature, it may coexist with conditions like chronic gastritis and iron deficiency anemia.</p><p><strong>Case presentation: </strong>A 71-year-old Turkish male presented with iron deficiency anemia, chronic fatigue, and upper abdominal pain. Endoscopy revealed yellowish-white plaques (2-6 mm) on the antral mucosa, confirmed as gastric xanthelasma on histopathology. Concurrently, a rectal sessile polyp was excised during colonoscopy. The patient recovered following a 3-month course of oral iron supplementation and proton pump inhibitors. Follow-up endoscopy showed resolution of gastric lesions.</p><p><strong>Conclusion: </strong>This report underscores the diagnostic importance of endoscopy and biopsy in patients with unexplained anemia and highlights the potential association between gastric xanthelasma and ron deficiency anemia, warranting further research.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"98"},"PeriodicalIF":0.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of a child with anterior blepharitis caused by Candida albicans: a case report.","authors":"Noriko Mukai, Yukiya Takeichi, Yamato Yoshikawa, Kensuke Tajiri, Teruyo Kida","doi":"10.1186/s13256-025-05129-x","DOIUrl":"10.1186/s13256-025-05129-x","url":null,"abstract":"<p><strong>Background: </strong>To date, there have been few detailed reports of the clinical findings in cases of fungal blepharitis. In this report, we present a rare case of anterior blepharitis in a Japanese child in whom Candida albicans was identified from secretions on the eyelash roots and present the clinical findings of the patient's eyelid margin via photograph documentation.</p><p><strong>Case presentation: </strong>This study involved a 6-year-old Japanese boy with Treacher-Collins syndrome and severe ulcerative colitis who, during a follow-up visit at the Department of Pediatrics at Osaka Medical and Pharmaceutical University Hospital, Takatsuki City, Osaka, Japan, suffered a cardiac arrest due to massive gastrointestinal hemorrhage, which led to persistent altered consciousness following resuscitation. Subsequently, the patient developed lagophthalmos, resulting in corneal ulcers caused by methicillin-resistant Staphylococcus aureus, which were successfully treated with a six-times-daily administration of 1% vancomycin ophthalmic ointment. Thereafter, the patient underwent a six-times-daily administration of ofloxacin ophthalmic ointment for the treatment of lagophthalmos keratitis. However, increased ocular discharge, upper eyelid edema, redness of the eyelash roots, and eyelash loss (madarosis) developed in his left eye, leading to a diagnosis of anterior blepharitis. Smear and culture tests of the eyelash root secretions revealed the presence of Candida albicans. The patient was then treated with a six-times-daily administered 1% pimaricin ophthalmic ointment, resulting in rapid resolution of the blepharitis and subsequent regrowth of the eyelashes.</p><p><strong>Conclusion: </strong>In this study, we report the clinical findings of a rare case of fungal anterior blepharitis in a Japanese child in which Candida albicans was identified. A noticeable white discharge at the base of the eyelashes and somewhat rapid eyelash loss were characteristic symptoms.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"94"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous tuberculosis and its pleomorphic presentations in human immunodeficiency virus-negative patients: a case report.","authors":"Rose Ekambi Kotto, Grace Anita Nkoro, Coralie Reine Mendouga Menye, Odette Berline Sigha, Ulrich Nguena Feungue, Christelle Ebongo Aboutou, Aristide Nguenmegne, Thierry Zo'obo, Edgar Mandeng Ma Linwa, Alain-Patrice Mélédié, Emmanuel Armand Kouotou","doi":"10.1186/s13256-024-04918-0","DOIUrl":"10.1186/s13256-024-04918-0","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous tuberculosis is reported to be rare, especially in human immunodeficiency virus-negative patients but probably also underdiagnosed. This is because it presents with pictorial and anatomoclinical polymorphism. In Africa, despite tuberculosis being endemic, isolating the germ and/or obtaining histopathological confirmation constitutes a significant challenge. Literature on the clinical presentations and outcomes of patients with cutaneous tuberculosis is sparse in Cameroon and sub-Saharan Africa. This prompted us to report on the cases of cutaneous tuberculosis we encountered.</p><p><strong>Case presentation: </strong>We report ten cases of cutaneous tuberculosis diagnosed in human immunodeficiency virus-negative patients from 2018 to 2022 in Cameroon. All cases included were confirmed by histology and/or laboratory test. The average age of our patients was 35.7 ± 20.3 years, with age ranges between 8 and 72 years. The sex ratio (M/F) was 1.5. The clinical forms identified were scrofuloderma (three cases), papulonecrotic tuberculid (two cases), and tuberculosis verrucosa cutis (two cases). Tubercular gumma, lupus vulgaris, and disseminated tuberculosis accounted for one case each. Under antituberculosis drugs, the clinical progress was favorable for all cases.</p><p><strong>Conclusion: </strong>Cutaneous tuberculosis can present in various forms. Though rare in our setting, physicians should consider this diagnosis when faced with any chronic skin lesion that does not respond to conventional treatment.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"90"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}