Journal of Medical Case Reports最新文献

{"title":"Isolated celiac artery vasculitis: a cause of recurrent abdominal pain in a young adult: a case report.","authors":"Ali Hajihashemi, Pardis Tavallaeinejad, Mahsa Geravandi","doi":"10.1186/s13256-025-05108-2","DOIUrl":"10.1186/s13256-025-05108-2","url":null,"abstract":"<p><strong>Background: </strong>Vasculitis encompasses a group of disorders characterized by inflammation of blood vessel walls, leading to diverse clinical presentations on the basis of the size and location of the affected vessels. Gastrointestinal involvement is a known feature of small- and medium-sized vessel vasculitides, typically as part of systemic inflammation. However, isolated vasculitis of the celiac artery is extremely rare and has been scarcely reported in the literature, making this case particularly novel and significant.</p><p><strong>Case presentation: </strong>We report the case of a 35-year-old Iranian male of Persian ethnicity who presented with a 7-day history of abdominal pain localized to the epigastric and periumbilical regions, accompanied by nausea. On admission, the patient's vital signs were stable, and clinical examination was unremarkable. Laboratory findings revealed elevated C-reactive protein and erythrocyte sedimentation rate. Contrast-enhanced abdominopelvic computed tomography suggested isolated vasculitis of the celiac artery. Subsequent serological tests showed borderline positive anti-nuclear antibodies, while other specific autoantibodies were negative. On the basis of clinical and radiological findings, the patient was diagnosed with isolated celiac artery vasculitis. Treatment with oral corticosteroids for 10 days led to symptom resolution and normalization of C-reactive protein levels. A follow-up computed tomography scan performed 2 weeks after treatment completion demonstrated complete resolution of inflammatory changes with no residual abnormalities. At 6-month follow-up, the patient remained asymptomatic, with no recurrence of symptoms or complications.</p><p><strong>Conclusion: </strong>Isolated celiac artery vasculitis is an extremely rare condition that requires high clinical suspicion for timely diagnosis. Early intervention can effectively prevent life-threatening complications and reduce morbidity. This case highlights the importance of recognizing isolated vascular inflammation as a potential diagnosis in patients presenting with unexplained abdominal pain and elevated inflammatory markers.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"89"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total atrioventricular block as a cardiac manifestation in Weil's disease: a case report.","authors":"Ivana Purnama Dewi, Arya Taksya Bagaskara, Andreas Mercyan Anggitama, Kadex Reisya Sita Damayanti, Ihdinal Mukti","doi":"10.1186/s13256-024-04970-w","DOIUrl":"10.1186/s13256-024-04970-w","url":null,"abstract":"<p><strong>Background: </strong>Weil's disease is an infection caused by Leptospira bacteria. Leptospirosis may cause arrhythmias, such as atrial fibrillation and ST-T segment changes. We report a rare case of total atrioventricular block induced by leptospirosis. Early diagnosis and prompt management present particular challenges.</p><p><strong>Case report: </strong>A 43-year-old Asian woman was referred from internal medicine to cardiology owing to an electrocardiogram abnormality. She complained of worsening chest discomfort 3 days earlier, accompanied by fever, nausea, and intermittent headaches. The patient appeared lethargic and jaundiced; blood pressure was 81/43 mmHg, heart rate was 41 bpm, respiratory rate was 20 times/minute, and temperature was 38.2 °C. The electrocardiogram showed a total atrioventricular block with a junctional escape rhythm of 45 bpm. Laboratory tests revealed increased renal and liver function, thrombocytopenia (98,000/µL), and positive immunoglobulin G and M anti-Leptospira. The patient was diagnosed with Weil's disease (Faine's score 32) and total atrioventricular block. The initial management involved fitting the patient with a transcutaneous pacemaker and giving dopamine 5 mcg/kgBW/minute, titrated to a target systolic blood pressure of > 90 mmHg. The patient was also scheduled to undergo temporary transvenous pacing. However, the patient died of suspected cardiogenic shock due to a deterioration in clinical condition.</p><p><strong>Conclusion: </strong>Leptospirosis can cause rare but fatal arrhythmias, as seen in this case of fulminant leptospirosis with total atrioventricular block. Clinicians should be vigilant and consider this potential complication in similar cases.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"91"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post coronavirus-disease-vaccination immune reconstitution inflammatory syndrome in tuberculosis treatment: a case report.","authors":"Aadit Mehta, Alok Pant","doi":"10.1186/s13256-025-05081-w","DOIUrl":"10.1186/s13256-025-05081-w","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis immune reconstitution inflammatory syndrome is an uncommon condition caused by excessive immune response against Mycobacterium tuberculosis. We report on a case which may have been precipitated by coronavirus disease messenger ribonucleic acid vaccine booster.</p><p><strong>Case presentation: </strong>A 47-year old Indian man developed reactivation tuberculosis in the cervical lymph nodes in the setting of immune suppression caused by tumor necrosis factor inhibitor adalimumab. The symptoms improved with starting antituberculous therapy, but 5 days after receiving a coronavirus disease booster messenger ribonucleic acid vaccine, he had recurrence of severe constitutional symptoms. After a detailed evaluation, he was diagnosed with immune reconstitution inflammatory syndrome and was successfully treated with high-dose steroid therapy, which was weaned off over several weeks.</p><p><strong>Conclusion: </strong>Immune reconstitution inflammatory syndrome should be considered as a differential in patients who develop paradoxical worsening of symptoms with antitubercular therapy in the setting of immune reconstitution. Hyperactive immune response after infection or messenger ribonucleic acid vaccine booster may have contributed to the development of immune reconstitution inflammatory syndrome syndrome in this patient.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"93"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheal nodularity and paratracheal soft tissue nodule: post-radioactive iodine treatment changes with peculiar visual and pathologic findings in a case of metastatic follicular variant papillary thyroid carcinoma: a case report.","authors":"Benjamin L Sievers, Wangpan Shi, Jingjing Hu, Russell Miller, Niral M Patel, Keriann Van Nostrand, George Z Cheng, Charles H Choe, Jorge Alberto Muñoz Pineda","doi":"10.1186/s13256-025-05116-2","DOIUrl":"10.1186/s13256-025-05116-2","url":null,"abstract":"<p><strong>Background: </strong>Follicular variant papillary thyroid carcinoma is a distinct subtype of papillary thyroid carcinoma that can occasionally present with aggressive features, including distant metastases and extrathyroidal extension. While radioactive iodine ablation is a well-established treatment for residual disease, its post-treatment effects on tracheal and paratracheal structures remain poorly characterized.</p><p><strong>Case presentation: </strong>A 22-year-old male individual of Taiwanese descent presented with an enlarged neck mass and was diagnosed with follicular variant papillary thyroid carcinoma. He underwent thyroidectomy, modified radical neck dissection, and postoperative radioactive iodine-131 ablation (100 mCi). A total of 1 year later, a chest computed tomography revealed a paratracheal soft tissue nodule and tracheal nodularity. Bronchoscopy with endobronchial ultrasound-guided sampling identified multiple 2-3 mm submucosal tracheal nodules containing white exudate. Cytopathologic analysis of both the paratracheal soft tissue nodule and the tracheal wall nodules revealed mucinous material without evidence of malignancy or inflammation. Microbiologic studies were negative for infection.</p><p><strong>Conclusion: </strong>These atypical bronchoscopic and pathologic findings likely represent post-radioactive iodine treatment changes. The patient remained without evidence of disease for 22 months, ongoing on thyroid suppression levels of thyroxine hormone replacement. The case represents successful radioactive iodine treatment of papillary thyroid carcinoma residual disease after surgical resection, with the first described pathologic findings to correlate with these post-treatment changes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"92"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis of the elbow joint: the complexity of diagnosis and treatment-A case report and review of literature.","authors":"J Manske, E Tille, A Schlüßler, A Biewener, J Nowotny","doi":"10.1186/s13256-025-05102-8","DOIUrl":"10.1186/s13256-025-05102-8","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis is one of the deadliest diseases worldwide, with an estimated incidence of more than 10 million new cases annually. As part of bone and joint tuberculosis (5-6% of all extrapulmonary tuberculosis cases), elbow tuberculosis is a rare manifestation-especially in the Western world-and is associated with nonspecific symptoms such as swelling, redness, and painful limitation of motion. This often leads to initial misdiagnoses, such as septic arthritis or rheumatoid arthritis, resulting in a significant delay in diagnosis and treatment.</p><p><strong>Case presentation: </strong>A 27-year-old male patient from Bangalore, South India presented with left elbow pain and restricted motion. The clinical and imaging findings led to the suspicion of olecranon bursitis. Intraoperatively, joint tuberculosis was suspected; therefore, multiple tissue samples were taken and a diagnostic routine according to guidelines was initiated. The tuberculosis-specific interferon gamma test was positive and thus confirmed the patient's previous contact with Mycobacterium tuberculosis. Since extrapulmonary tuberculosis is often caused by multidrug-resistant mycobacterial strains, tuberculostatic therapy was started after obtaining the resistogram. Under the initiated therapy, a reduction in synovial inflammation on magnetic resonance imaging and a rehabilitation of the mobility of the elbow were achieved over a period of more than 15 months.</p><p><strong>Conclusion: </strong>The basis for finding the diagnosis is a detailed, interdisciplinary diagnostic process, especially in patients with persisting unspecific symptoms, since joint tuberculosis is frequently the only site of manifestation. Despite the slow growth of mycobacteria, the microbiological findings, particularly the resistogram, should be awaited since extrapulmonary tuberculosis is often multidrug resistant. As shown in this case, surgical treatment is important for reliable diagnosis, including pathogen identification, but it is not mandatory for successful healing and regaining functionality of the affected joint.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"88"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of laryngeal leishmaniasis presenting as hoarseness in an Ethiopian patient: a case report.","authors":"Mohammedsefa Arusi Dari, Zelalem Tadesse Wondimu, Melaku Abay Muluneh, Martha Mekonen Gdey, Adil Fekede Ayele","doi":"10.1186/s13256-025-05134-0","DOIUrl":"10.1186/s13256-025-05134-0","url":null,"abstract":"<p><strong>Background: </strong>Leishmaniasis is a zoonotic disease caused by unicellular protozoa of the Leishmania genus. The infection can spread through zoonotic or anthroponotic transmission, depending on the species, with the phlebotomine sandfly serving as the primary vector. Leishmaniasis is endemic in tropical regions of Asia and Africa. While mucocutaneous leishmaniasis is rarely reported in Ethiopia, both the cutaneous and visceral forms of the disease are more commonly seen. The clinical spectrum of Leishmania infection includes visceral leishmaniasis (the most common form), as well as cutaneous, mucocutaneous, mucosal, and post-kala-azar dermal leishmaniasis. The mucosal form typically involves the nasal and oral mucosa, though in rare cases, it can also affect the laryngeal and pharyngeal mucosa.</p><p><strong>Case presentation: </strong>This report discusses a case of laryngeal leishmaniasis presenting as hoarseness of voice and discomfort during swallowing, with a focus on clinical presentation, diagnostic process, and management. A 31-year-old Ethiopian man from Addis Ababa, Ethiopia, presented with a 6-month history of hoarseness and difficulty swallowing. He had a history of travel to Humera, a region endemic for leishmaniasis. Flexible nasolaryngoscopy revealed whitish erythema and irregular margins on the right vocal cord. Laryngeal cancer was initially suspected, and a microlaryngoscopy with biopsy was performed, which confirmed the presence of Leishmania amastigotes. He was treated with liposomal amphotericin B. After completing the treatment, his voice returned to normal, and repeat nasolaryngoscopy showed no abnormalities.</p><p><strong>Conclusion: </strong>Laryngeal leishmaniasis is a rare but important differential diagnosis for patients presenting with hoarseness, particularly those with a history of travel to endemic areas. Clinicians should consider leishmaniasis in the differential diagnosis of upper respiratory symptoms in endemic regions, even in the absence of classic skin lesions. Early diagnosis and appropriate treatment with antifungal agents such as liposomal amphotericin B can lead to full recovery, as demonstrated in this case.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"86"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dorsally exophytic brain stem ganglioglioma extending to the foramen of Luschka: a case report.","authors":"Ege Anil Ucar, Utku Ozgen, Talat Kiris","doi":"10.1186/s13256-025-05128-y","DOIUrl":"10.1186/s13256-025-05128-y","url":null,"abstract":"<p><strong>Background: </strong>Gangliogliomas are rare tumors primarily arising from the central nervous system, mostly in the temporal lobes, with brain stem involvement being particularly infrequent. To the best of our knowledge, this is the first reported instance of a brainstem ganglioglioma exhibiting an extension to foramen of Luschka.</p><p><strong>Case presentation: </strong>We present a unique case of ganglioglioma of the brainstem. 23-year-old Turkish patient presented with flashing lights in the peripheral visual fields. Imaging studies revealed a distinct mass lesion adjacent to the brainstem, demonstrating an unusual exophytic growth pattern that extended towards the foramen of Luschka. Surgical intervention was performed to prevent tumor progression and obtain a definitive diagnosis. The surgical approach employed was the telovelar approach, which provides excellent visualization of the posterior fossa. Histopathological examination of the resected specimen confirmed the diagnosis of grade 1 ganglioglioma. Postoperative magnetic resonance imaging scans displayed gross total resection of the tumor. The patient's postoperative course was uneventful, and the initial symptom of flashing lights resolved in the postoperative period.</p><p><strong>Conclusion: </strong>This case report highlights the uniqueness of a dorsally exophytic brain stem ganglioglioma extending to the foramen of Luschka. Utilization of the telovelar approach and sodium fluorescein in the surgical management of this challenging case underscores its efficacy in managing deep-seated lesions within the posterior fossa. Although presenting infrequently, gangliogliomas should be considered in the differential diagnosis of lesions of the foramen of Luschka because early recognition is important for the management and prognosis.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"87"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The formation of portal venous system thrombosis after blunt abdominal trauma: a case report.","authors":"Zhidong Wang, Huan Tong, Hao Wu","doi":"10.1186/s13256-025-05125-1","DOIUrl":"10.1186/s13256-025-05125-1","url":null,"abstract":"<p><strong>Introduction: </strong>Portal venous system thrombosis accompanied by intestinal infarction is a rare complication following blunt abdominal trauma. It is known to be caused by liver cirrhosis. Herein, we describe the clinical manifestations and treatment of portal venous system thrombosis in a patient, confirmed by imaging and pathology.</p><p><strong>Case presentation: </strong>A 38-year-old Chinese woman presented with abdominal pain and vomiting after a car accident. Portal venous system thrombosis without other thrombophilic states was diagnosed via computed tomography angiography after 2 months. The patient developed small bowel infarction and received successful treatment via anticoagulation and surgery.</p><p><strong>Conclusion: </strong>This report demonstrates that vascular injury, including both hemorrhage and ischemia, should be considered in the differential diagnosis after abdominal trauma. Clinicians should be aware of portal venous system thrombosis following acute abdomen, especially when clinical presentations do not correspond to common situations. Early anticoagulation therapy can improve prognosis once the diagnosis is established.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"85"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected postoperative incidental recurrent laryngeal nerve palsy post total thyroidectomy after intraoperative nerve monitoring (overstimulation and fatigability): a case report.","authors":"Saad Alshehri, Faisal Alsarrani, Abdulaziz Aldrees, Ahad Alotaibi, Sarah Alsadun, Abdulrahman Almalik","doi":"10.1186/s13256-025-05079-4","DOIUrl":"10.1186/s13256-025-05079-4","url":null,"abstract":"<p><strong>Background: </strong>Postoperative recurrent or permanent recurrent laryngeal nerve injury is one of the most serious complications in the field of thyroid surgery, in either benign or malignant thyroid disease, significantly affecting patients' quality of life. The importance of recurrent laryngeal nerve identification intraoperatively reduces the risk of injury. We report herein a young patient who underwent nerve monitoring in total thyroidectomy that led to recurrent laryngeal nerve injury.</p><p><strong>Case presentation: </strong>We report a 30-year-old Arab male patient who presented to our clinic with a longstanding thyroid swelling, which was reported as papillary thyroid carcinoma, and was scheduled for total thyroidectomy and lymph node dissection. Nerve monitoring was used to identify the recurrent laryngeal nerve, leading to recurrent laryngeal nerve nerve fatigability/paresis that was seen during the postoperative course.</p><p><strong>Conclusion: </strong>Visual identification of the recurrent laryngeal nerve is the gold standard for nerve protection. We recommend the use of nerve monitoring as an adjunct in challenging cases but not in routine settings, as it does not decrease the incidence of injuries compared with visualization alone in our experience.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"82"},"PeriodicalIF":0.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clival fibrous dysplasia in which short interval disease progression posed a diagnostic challenge in a skeletally mature patient: a case report.","authors":"Sujitra Tinnut, Nancy Pham, Jayakar Nayak, Juan C Fernandez-Miranda, Hannes Vogel, Nancy Fischbein","doi":"10.1186/s13256-025-05104-6","DOIUrl":"10.1186/s13256-025-05104-6","url":null,"abstract":"<p><strong>Background: </strong>Fibrous dysplasia is an uncommon bone disorder in which medullary bone is replaced by disorganized fibro-osseous tissue. Fibrous dysplasia typically exhibits slow growth that stabilizes with skeletal maturity. We report a case in which rapid progression of a clival lesion otherwise typical for fibrous dysplasia in an adult male led to concern for a malignant rather than a benign lesion.</p><p><strong>Case presentation: </strong>A 38 year-old white male developed eye pain, and magnetic resonance imaging of the brain was interpreted as normal. A total of 2 years later, the patient again presented with eye pain, and a repeat magnetic resonance imaging study demonstrated interval development of a lesion replacing much of the clivus. Though the lesion appeared fairly typical of fibrous dysplasia, with magnetic resonance imaging and subsequent computed tomography revealing a well-defined and mildly expansile clival lesion, lesions of fibrous dysplasia do not typically appear in skeletally mature patients, and they are generally indolent. On the basis of concern for malignant degeneration or possibly an alternative diagnosis, as the patient had been referred to our center with a diagnosis of clival chordoma, the lesion was treated with endoscopic resection. The diagnosis of typical fibrous dysplasia was ultimately confirmed through histopathological, immunohistochemical, and genetic analysis.</p><p><strong>Conclusion: </strong>This case demonstrates the potential for development and progression of benign fibrous dysplasia lesions beyond skeletal maturity, a phenomenon rarely reported in literature and not previously demonstrated in the clivus.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"83"},"PeriodicalIF":0.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}