Journal of Medical Case Reports最新文献

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Recurrent ovarian inguinal hernia complicated with Mayer-Rokitansky-Küster-Hauser syndrome: a case report. 复发性卵巢腹股沟疝合并mayer - rokitansky - k<s:1> ster- hauser综合征1例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-25 DOI: 10.1186/s13256-025-05262-7
Weichao Liang, Qisheng Chen, Yihao Ma, Yingchang Zhu
{"title":"Recurrent ovarian inguinal hernia complicated with Mayer-Rokitansky-Küster-Hauser syndrome: a case report.","authors":"Weichao Liang, Qisheng Chen, Yihao Ma, Yingchang Zhu","doi":"10.1186/s13256-025-05262-7","DOIUrl":"10.1186/s13256-025-05262-7","url":null,"abstract":"<p><strong>Background: </strong>Herniation of female genital organs complicated by Mayer-Rokitansky-Küster-Hauser syndrome in adolescents is rarely reported in previous studies, and delayed diagnosis or misdiagnosis of this situation can lead to serious injury.</p><p><strong>Case presentation: </strong>Herein, we report a 13-year-old Chinese female patient who presented with a recurrent left inguinal mass. The patient was diagnosed with herniation of the uterus, ovaries, and fallopian tubes into the inguinal canal complicated by adolescent Mayer-Rokitansky-Küster-Hauser syndrome. We provide anatomic, diagnostic, and therapeutic considerations for this rare phenomenon. The malformed uterus, ovaries, and fallopian tubes were returned to the abdominal cavity using the Bassini technique for inguinal hernia. No intraoperative or postoperative complications were reported, and the patient made a good postoperative recovery.</p><p><strong>Conclusion: </strong>This study highlights the coexistence of Mayer-Rokitansky-Küster-Hauser syndrome with inguinal hernia. Early and accurate diagnosis is crucial for successful intervention. Individualized surgical and follow-up strategies play a key role in optimizing both physical and mental recovery.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"251"},"PeriodicalIF":0.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microapical surgery of a periapical cyst caused by apical ramification: a case report and review of the literature. 根尖分叉引起的根尖周围囊肿的显微根尖手术:1例报告及文献复习。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-23 DOI: 10.1186/s13256-025-05234-x
Liyun Bai, Na Hu, Qin Yang, Dongquan Pu, Xiaoqian Feng, Yiyun Yue, Weiwei Xiao, Rui Liu, Li Liu, Xia Zhou
{"title":"Microapical surgery of a periapical cyst caused by apical ramification: a case report and review of the literature.","authors":"Liyun Bai, Na Hu, Qin Yang, Dongquan Pu, Xiaoqian Feng, Yiyun Yue, Weiwei Xiao, Rui Liu, Li Liu, Xia Zhou","doi":"10.1186/s13256-025-05234-x","DOIUrl":"10.1186/s13256-025-05234-x","url":null,"abstract":"<p><strong>Background: </strong>The destruction of tooth apical bone mainly comes from odontogenic apical cysts caused by pulp necrosis, chronic inflammation, or trauma. Some affected teeth can be cured by modern root canal treatment or non-surgical retreatment, but some affected teeth do not heal after treatment. Apical surgery should be considered when root canal therapy has failed, root canal retreatment through the crown channel is difficult, or true cysts are present. This article explores the use of microapical surgery to treat a periapical cyst caused by apical ramification, emphasizing a minimal surgical approach for this lesion.</p><p><strong>Case presentation: </strong>A 47-year-old female (Han nationality) presented with a chief complaint of recurrent buccal mucosal fistula in their maxillary posterior teeth for 1 year. Clinical examination revealed a porcelain-fused-metal crown of the maxilla of the left second premolar (tooth 25) and buccal mucosa fistula. X-ray assessment showed a high-density shadow in the root canal and low-density transmission from the root apex to the middle third of distal root surface. Microscopic apical surgery was performed under local anesthesia. The apical ramification was exposed and a root apex of 3 mm was cut off. Then the apical foramen of buccal root canal, palatal root canal, and apical ramification were filled retrogradely with mineral trioxide aggregate, and finally sewn up. Follow-up X-ray at postoperative 12 months and 24 months showed that the bone density of the root apex and distal root surface was higher compared with the values measured immediately after operation. There were no clinical symptoms, and normal mucosa.</p><p><strong>Conclusion: </strong>The patient presented with a recurrent buccal mucosal fistula in the maxillary left second premolar. Microscopic apical surgery was performed under local anesthesia. After minimally invasive surgery, apical resection, inverted preparation, and mineral trioxide aggregate treatment, at postoperative 24 months, the outcome was satisfactory, with recovered apical bone, normal mucosa, and no clinical symptoms. For periapical cysts, X-ray and cone-beam computed tomography images should be read carefully before the operation. The semicircular low-density transmission image around the apical sidewall indicates the apical ramification, and that root canal treatment or microapical surgery should be performed. The operating microscope enhances visibility and provides the surgeon with a better understanding of canal anatomy, a better surgical view, and the ability to undertake more complex but predictable apical resection techniques.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"249"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine arteriovenous malformation or uterine artery pseudoaneurysm secondary to uterine aspiration in cesarean scar ectopic pregnancy: a case report and review of the literature. 剖宫产瘢痕异位妊娠子宫抽吸继发子宫动静脉畸形或子宫动脉假性动脉瘤1例报告并文献复习。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-23 DOI: 10.1186/s13256-025-05312-0
Ngoc Diep Le, Phuc Nhon Nguyen
{"title":"Uterine arteriovenous malformation or uterine artery pseudoaneurysm secondary to uterine aspiration in cesarean scar ectopic pregnancy: a case report and review of the literature.","authors":"Ngoc Diep Le, Phuc Nhon Nguyen","doi":"10.1186/s13256-025-05312-0","DOIUrl":"10.1186/s13256-025-05312-0","url":null,"abstract":"<p><strong>Introduction: </strong>Uterine arteriovenous malformation or uterine artery pseudoaneurysm after the treatment of cesarean scar ectopic pregnancy is a scarce entity, leading to potentially life-threatening conditions due to the massive bleeding. The management remains significantly crucial. Herein, we report an uncommon case with surgical management of such a rare condition at our center.</p><p><strong>Presentation case: </strong>A 31-year-old Vietnamese female patient (gravida 2, para 1) was hospitalized for cesarean scar pregnancy. The uterine aspiration was well performed. However, the woman was readmitted for an abnormally persistent hypervascularity at the site of cesarean scar ectopic pregnancy under repeated ultrasound scans. After counseling, arteriovenous malformation was suspected more, whereas uterine pseudoaneurysm was incompletely ruled out. Initially, gonadotropin-releasing hormone agonist was administered, with two doses of 37.5 mg. Later, the patient underwent laparoscopic intervention to suture the vascular proliferation mass to prevent spontaneous rupture. The surgery was achieved successfully. One more dose of gonadotropin-releasing hormone agonist was added. The ultrasound detected no existing lesion compared with previous ultrasonic imaging and serum beta-human chorionic gonadotropin declined to a negative value. The patient was monitored in 1 month uneventfully.</p><p><strong>Conclusion: </strong>A high index of suspicion of uterine arteriovenous malformation or uterine artery pseudoaneurysm should be raised after uterine curettage of cesarean scar ectopic pregnancy. Ultrasound scan is still a pivotal first-line tool in assessing this abnormality. Laparoscopic surgery with compressing suture of the enhanced myometrial vascularity/arteriovenous malformation combined with administration of gonadotropin-releasing hormone agonist may be applied. This surgical approach has not been reported before, which makes our case report unique. Further cases are required for this rare entity so as to ensure patient safety.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"248"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transradial retrograde percutaneous coronary intervention of chronic total occlusion using a single guiding catheter: a case report. 单导管经桡动脉逆行经皮冠状动脉介入治疗慢性全闭塞1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-23 DOI: 10.1186/s13256-025-05313-z
Georgi Goranov, Petko Petrov
{"title":"Transradial retrograde percutaneous coronary intervention of chronic total occlusion using a single guiding catheter: a case report.","authors":"Georgi Goranov, Petko Petrov","doi":"10.1186/s13256-025-05313-z","DOIUrl":"10.1186/s13256-025-05313-z","url":null,"abstract":"<p><strong>Background: </strong>With the development of specialized equipment and the retrograde technique, success rates for percutaneous coronary intervention of chronic total occlusions have increased from 60 to 90% in the past 10 years. Performing percutaneous coronary intervention via a collateral channel from the contralateral artery, using two guiding catheters, is usually the preferred approach to retrograde chronic total occlusion-percutaneous coronary intervention. In the case described in this report, we performed successful retrograde revascularization of chronic total occlusion of dominant left circumflex artery via the ipsilateral septal collateral artery from the left anterior descending artery. The procedure was performed successfully through radial artery access using a single guiding catheter. An 85-year-old white Bulgarian Caucasian male patient, with a history of lateral and inferior myocardial infarction 20 years ago and previous percutaneous coronary intervention, underwent a planned coronary arteriography owing to his complaints of typical angina symptoms. Coronary angiography revealed three-vessel coronary artery disease with patent implanted drug-eluting stents in the mid-left anterior descending artery and in the proximal right coronary artery and chronic total occlusion of dominant left circumflex artery. A septal branch in the midsegment of left anterior descending artery was supplying the distal left circumflex artery retrogradely. After repeated failed attempts at antegrade percutaneous coronary intervention for the left circumflex artery's chronic total occlusion, the retrograde approach was tried. This intervention finally succeeded through the ipsilateral septal collateral. It was performed via a single radial artery access throughout the whole process. Postoperatively, the patient had no complications and was stable at the 6-month follow-up.</p><p><strong>Conclusion: </strong>The transradial approach to retrograde percutaneous coronary intervention for chronic total occlusions via an ipsilateral septal collateral using a single guiding catheter is feasible and safe in appropriately selected cases.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"247"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant hyperthermia: patient undergoing limb debridement surgery-a case report. 恶性高热:行肢体清创手术1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-23 DOI: 10.1186/s13256-025-05299-8
Zhixiang Geng, Jinling Yang, An Wang, Xiaoling Chen, Rujie Chen, Zhongwang Li, Xiaolong Zhang
{"title":"Malignant hyperthermia: patient undergoing limb debridement surgery-a case report.","authors":"Zhixiang Geng, Jinling Yang, An Wang, Xiaoling Chen, Rujie Chen, Zhongwang Li, Xiaolong Zhang","doi":"10.1186/s13256-025-05299-8","DOIUrl":"10.1186/s13256-025-05299-8","url":null,"abstract":"<p><strong>Background: </strong>Malignant hyperthermia is a rare but potentially fatal clinical emergency, primarily triggered by inhaled volatile anesthetics. It is associated with inherited autosomal-dominant skeletal muscle disorders and typically caused by mutations in muscle calcium channel genes. Owing to its rapid onset and severe complications, prompt diagnosis and intervention are crucial. This case report highlights a unique instance of malignant hyperthermia, emphasizing the importance of early detection and timely treatment in saving a patient's life.</p><p><strong>Case presentation: </strong>A 30-year-old Han Chinese male underwent limb debridement surgery twice within 4 days, and, during the second surgery, he developed signs of malignant hyperthermia following the administration of inhaled anesthetics. The patient presented with hyperthermia, tachycardia, hypercapnia, and masseter spasm. Clinical diagnosis of malignant hyperthermia was confirmed, and immediate treatment with dantrolene was initiated. A multidisciplinary approach was employed to manage the condition, leading to successful stabilization and recovery. The patient ultimately made a full recovery without further complications. After the surgery, the patient underwent genetic testing, and no clear pathogenic genes were found; however, there were some suspicious related genes.</p><p><strong>Conclusion: </strong>This case underscores the critical importance of the early recognition of malignant hyperthermia and the prompt administration of dantrolene, which is vital in mitigating its life-threatening consequences. It also highlights the need for thorough preoperative screening for patients at risk of malignant hyperthermia and suggests improvements in treatment protocols to optimize patient outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"250"},"PeriodicalIF":0.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical treatment of giant sacral terminal filar cysts: a case report and review of the literature. 巨大骶端丝状囊肿的手术治疗:1例报告及文献复习。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-22 DOI: 10.1186/s13256-025-05306-y
Shuai Li, Guoqing Wu, XiangJin Gu, Danglin Zhang, Xuesheng Zheng
{"title":"Surgical treatment of giant sacral terminal filar cysts: a case report and review of the literature.","authors":"Shuai Li, Guoqing Wu, XiangJin Gu, Danglin Zhang, Xuesheng Zheng","doi":"10.1186/s13256-025-05306-y","DOIUrl":"10.1186/s13256-025-05306-y","url":null,"abstract":"<p><strong>Background: </strong>Sacral terminal filar cysts are a rare and distinctive type of sacral canal cyst, which are anatomically characterized by the presence of filum terminale within the cyst rather than nerve roots. Given their rarity and therapeutic challenges, the presentation of this case report aims to share a novel and effective treatment approach, providing valuable reference for clinicians.</p><p><strong>Case presentation: </strong>A 39-year-old Chinese woman patient presented to our hospital with symptoms including lumbosacral pain, anal distension, increased frequency of urination, and incomplete urination. Magnetic resonance imaging scans revealed a sacral canal cyst compressing the adjacent sacral nerve roots. We performed minimally invasive surgery, guided by magnetic resonance imaging and computed tomography scans, to precisely remove the cyst. Six months postoperatively, a follow-up visit revealed normalized bowel and bladder functions, indicating a successful outcome.</p><p><strong>Conclusion: </strong>The present study proposes an effective treatment strategy for sacral terminal filar cysts. Initially, magnetic resonance imaging scan results were employed to ascertain the location of the leak and to identify the corresponding cross-section of the leak in the computed tomography scan results. Subsequently, three-dimensional reconstruction of the computed tomography scan results was conducted to determine the extent of a visualized surgical incision. Ultimately, minimally invasive surgical treatment was performed.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"246"},"PeriodicalIF":0.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Mycobacterium tuberculosis in a patient with suspected cystic echinococcosis: a case report. 疑似囊性包虫病患者结核分枝杆菌检测1例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-21 DOI: 10.1186/s13256-025-05286-z
Simon Daller, Julian Frederic Hotz, Moritz Staudacher, Polina Kalinina, Susanna Lang, Fredrik Waneck, Heimo Lagler
{"title":"Detection of Mycobacterium tuberculosis in a patient with suspected cystic echinococcosis: a case report.","authors":"Simon Daller, Julian Frederic Hotz, Moritz Staudacher, Polina Kalinina, Susanna Lang, Fredrik Waneck, Heimo Lagler","doi":"10.1186/s13256-025-05286-z","DOIUrl":"10.1186/s13256-025-05286-z","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis is a global health issue affecting millions of people worldwide. While pulmonary tuberculosis is common, hepatic tuberculosis is rare and accounts for less than 1% of cases. Diagnosis is challenging owing to nonspecific symptoms and its ability to mimic other hepatic diseases.</p><p><strong>Case presentation: </strong>This case report describes a 62-year-old male healthcare worker, originally from the Philippines and of Filipino ethnicity, who was initially suspected to have cystic echinococcosis, an epidemiologically uncommon zoonotic disease in both Austria and the Philippines. Echinococcosis was excluded by ultrasound and serology. Several other differential diagnoses, including pyogenic and amoebic liver abscesses, brucellosis, hepatocellular carcinoma, and hepatic metastases of other malignancies, were also ruled out. Ultimately, a biopsy of the liver lesion was performed, and the tissue tested positive for Mycobacterium tuberculosis complex by polymerase chain reaction. The patient was successfully treated with a standard 6-month antitubercular combination therapy.</p><p><strong>Conclusion: </strong>This case highlights the potential for tuberculosis to affect any organ system, including the liver, particularly in patients from high-burden regions.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"245"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rimegepant in airplane headache treatment: a case report. 大剂量药物治疗飞机头痛1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-21 DOI: 10.1186/s13256-025-05304-0
Massimo Autunno, Marcella De Luca, Ludovica Ferraù, Carmelo Rodolico
{"title":"Rimegepant in airplane headache treatment: a case report.","authors":"Massimo Autunno, Marcella De Luca, Ludovica Ferraù, Carmelo Rodolico","doi":"10.1186/s13256-025-05304-0","DOIUrl":"10.1186/s13256-025-05304-0","url":null,"abstract":"<p><strong>Background: </strong>Airplane headache is a rare condition first identified in 2004 and subsequently included in the International Classification of Headache Disorders (Headache Classification Committee of the International Headache Society in Cephalalgia 33:629-808, 2013. https://doi.org/10.1177/0333102413485658 ). Airplane headache typically presents as intense, stabbing, unilateral pain in the frontal or orbital regions, with a severity of 8-10 on the numeric rating scale. Despite its relatively low prevalence and generally nondisabling nature, the intense pain associated with airplane headache often leads to significant anxiety and fear of flying, underscoring the need for effective treatment strategies. Currently, there are no established guidelines for the treatment of airplane headache. Various anecdotal treatments have been reported, including nasal decongestants, nonsteroidal antiinflammatory drugs, and triptans.</p><p><strong>Case presentation: </strong>We describe the case of a 28-years old Caucasian female patient with recurrent airplane headache successfully treated with rimegepant, a calcitonin gene-related peptide receptor antagonist, taken half an hour before plane departure. A 10-month follow-up confirmed the treatment efficacy.</p><p><strong>Conclusion: </strong>This novel use of rimegepant, typically employed in migraine management, demonstrates a promising therapeutic option for airplane headache.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"243"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A response of rituximab plus lenalidomide therapy in patients with post-transplant lymphoproliferative disease and methotrexate-related lymphoproliferative disorder in the central nervous system: a case report. 利妥昔单抗联合来那度胺治疗移植后淋巴细胞增生性疾病和中枢神经系统甲氨蝶呤相关淋巴细胞增生性疾病的疗效:1例报告
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-21 DOI: 10.1186/s13256-025-05307-x
Hanguo Guo, Hong Zhang, Wenyu Li
{"title":"A response of rituximab plus lenalidomide therapy in patients with post-transplant lymphoproliferative disease and methotrexate-related lymphoproliferative disorder in the central nervous system: a case report.","authors":"Hanguo Guo, Hong Zhang, Wenyu Li","doi":"10.1186/s13256-025-05307-x","DOIUrl":"10.1186/s13256-025-05307-x","url":null,"abstract":"<p><strong>Background: </strong>Post-transplant lymphoproliferative disorder and methotrexate-related lymphoproliferative disorder are rare complications normally with unfavorable prognosis. Post-transplant lymphoproliferative disorder of the central nervous system is a rare disorder and predominantly presents as diffuse large B-cell lymphomas of non-germinal center cell origin. However, the treatment for these patients with this diagnosis has not reached a consensus. CASE 1 AND 2 PRESENTATIONS: In this case report, one patient with post-transplant lymphoproliferative disorder and another patient with methotrexate-related lymphoproliferative disorder were both diagnosed with Epstein-Barr virus-diffuse large B-cell lymphomas of primary central nervous system. The former case was a 37-year-old Han Chinese female diagnosed with post-transplant lymphoproliferative disorder of the central nervous system after a kidney transplant, and the latter case was a 61-year-old Han Chinese male diagnosed with methotrexate-related lymphoproliferative disorder after receiving methotrexate treatment for psoriasis. The initial treatment for both of them was rituximab plus lenalidomide followed by lenalidomide as maintenance for disease progression or intolerance. After the treatment, magnetic resonance imaging showed partial response or complete remission of their brain lesions. In addition, the renal function of the patient with post-transplant lymphoproliferative disorder of the central nervous system was normal, and psoriasis did not recur in the patient with methotrexate-related lymphoproliferative disorder during lenalidomide maintenance treatment.</p><p><strong>Conclusion: </strong>The treatment has proved to be a promising therapeutic method for post-transplant lymphoproliferative disorder of the central nervous system and methotrexate-related lymphoproliferative disorder, when the decreasing or withdrawal of immunosuppressive therapy could not achieve a satisfying outcome. Owing to the relatively small sample size, the effect of this treatment should be further investigated under a larger sample size.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"244"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteomyelitis of the great trochanter after removal of a femoral nail: a case report. 股骨钉拔除后大转子骨髓炎1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-20 DOI: 10.1186/s13256-025-05291-2
A Cosentino, G Odorizzi, W Berger
{"title":"Osteomyelitis of the great trochanter after removal of a femoral nail: a case report.","authors":"A Cosentino, G Odorizzi, W Berger","doi":"10.1186/s13256-025-05291-2","DOIUrl":"10.1186/s13256-025-05291-2","url":null,"abstract":"<p><strong>Background: </strong>Osteomyelitis following orthopedic hardware removal is a rare but serious complication, particularly in pediatric patients. This case report describes a unique instance of osteomyelitis of the great trochanter following the removal of a femoral nail in a 14-year-old girl, highlighting diagnostic challenges and management strategies.</p><p><strong>Case presentation: </strong>A 14-year-old Mediterranean white girl presented with persistent pain and swelling at the site of a previously removed femoral nail, used to treat a prior femoral shaft fracture. Symptoms developed 2 weeks post-removal, accompanied by erythema and increased warmth over the great trochanter. Laboratory findings showed elevated inflammatory markers. Imaging studies, including magnetic resonance imaging, confirmed osteomyelitis of the great trochanter. The patient underwent surgical debridement, followed by targeted intravenous antibiotic therapy based on culture sensitivities. The patient responded well to surgical debridement and a 3-week course of intravenous antibiotics, with subsequent transition to oral antibiotics. Follow-up at 1 year showed resolution of symptoms, normalization of inflammatory markers, and no signs of infection recurrence on imaging. The patient was free of pain, demonstrated complete range of motion, and the wound showed no signs of infection, as confirmed by clinical examination and accompanying photographs.</p><p><strong>Conclusion: </strong>This case underscores the importance of prompt diagnosis and comprehensive management of osteomyelitis following hardware removal in pediatric patients. Early intervention with appropriate surgical and antibiotic treatment can lead to excellent outcomes in managing this rare complication.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"241"},"PeriodicalIF":0.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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