Journal of Medical Case Reports最新文献

筛选
英文 中文
Recurrent breast abscess leading to an incidental diagnosis of tuberculous mastitis: a case report. 复发性乳房脓肿导致偶然诊断为结核性乳腺炎:1例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-21 DOI: 10.1186/s13256-026-06493-y
Shital Shrikant Ghogale, Ketaki Niranjan Pathak
{"title":"Recurrent breast abscess leading to an incidental diagnosis of tuberculous mastitis: a case report.","authors":"Shital Shrikant Ghogale, Ketaki Niranjan Pathak","doi":"10.1186/s13256-026-06493-y","DOIUrl":"10.1186/s13256-026-06493-y","url":null,"abstract":"<p><strong>Background: </strong>Breast abscesses are commonly seen in lactating and non-lactating women due to bacterial infections, often caused by Staphylococcus aureus. Recurrent abscesses pose a therapeutic challenge. Tuberculous mastitis (TM) is a rare but important differential diagnosis, often misdiagnosed as pyogenic abscesses or malignancies. Routine AFB staining and molecular testing are recommended for all atypical or recurring breast abscesses in endemic regions to rule out tuberculous mastitis.</p><p><strong>Case presentation: </strong>We report a case of a 26-year-old Indian female presenting with recurrent right breast abscess. On local examination there was a 4 × 3 cm tender, fluctuant swelling in the upper outer quadrant of the right breast with erythema and raised temperature; no nipple retraction or axillary lymphadenopathy was noted. She denied systemic symptoms such as chronic cough, fever, night sweats, or unintended weight loss. The abscess was managed with incision and drainage followed by secondary suturing. Routine Ziehl-Neelsen staining of the pus revealed acid-fast bacilli (AFB), prompting cartridge-based nucleic acid amplification test (CBNAAT) and culture which confirmed Mycobacterium tuberculosis; Rapid Tuberculosis (TB) Ag MPT64 was also positive. Antitubercular therapy (ATT) was initiated as per national guidelines.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering tuberculous mastitis in recurrent or non-resolving breast abscesses, particularly in endemic settings. Early microbiological evaluation, including AFB staining and molecular assays, is essential for accurate diagnosis and timely initiation of anti-tuberculous therapy, thereby preventing repeated interventions and morbidity.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single and multiple oral giant cell fibromas: a case report and review of the literature. 单发及多发口腔巨细胞纤维瘤1例报告及文献复习。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-21 DOI: 10.1186/s13256-026-06534-6
Ghada Alaa Mohamed Aziz, Basma Ahmed Hamed, Iman Mohamed Helmy
{"title":"Single and multiple oral giant cell fibromas: a case report and review of the literature.","authors":"Ghada Alaa Mohamed Aziz, Basma Ahmed Hamed, Iman Mohamed Helmy","doi":"10.1186/s13256-026-06534-6","DOIUrl":"10.1186/s13256-026-06534-6","url":null,"abstract":"<p><strong>Introduction: </strong>Giant cell fibroma (GCF), a benign fibrous growth, accounts for about 4.7% of all oral benign or reactive fibrous growths. GCF commonly occurs in Caucasians, with a minor female predilection and a peak occurrence in the first three decades of life. Clinically, gingival nodules that are roughly 1 cm in diameter are commonly seen. Diagnosis relies on histopathological features, as clinical features are not sufficient on their own.</p><p><strong>Case presentation: </strong>Here, we report Egyptian case series of three female and two male patients with GCFs, with age range from 15 to 64 years. Three of them occurred in relatively uncommon locations (tongue and buccal mucosa). Some of the patients had esthetic concerns and others had masticatory problems. The first case was multiple, which is extremely rare. The lesions were removed surgically and depending on the histopathological features, a final diagnosis of giant cell fibroma was established.</p><p><strong>Conclusions: </strong>It is crucial for dentists to identify GCFs due to their frequent occurrence and to consider them when making a differential diagnosis with other fibrous hyperplastic diseases of the oral cavity, not only solitary lesions but also multiple lesions.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic challenges in primary aldosteronism evaluation and finerenone use. 原发性醛固酮增多症评估和精烯酮使用的诊断挑战。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-19 DOI: 10.1186/s13256-026-06619-2
Yuwan Xu, Ke Song, Shuairan Wu, Jing Li, Sancong Pan
{"title":"Diagnostic challenges in primary aldosteronism evaluation and finerenone use.","authors":"Yuwan Xu, Ke Song, Shuairan Wu, Jing Li, Sancong Pan","doi":"10.1186/s13256-026-06619-2","DOIUrl":"https://doi.org/10.1186/s13256-026-06619-2","url":null,"abstract":"<p><strong>Introduction: </strong>Primary aldosteronism (PA) is a common but frequently ignored cause of hypertension, particularly in patients with normal serum potassium and aldosterone levels.</p><p><strong>Case presentation: </strong>We report the case of a 70-year-old Han Chinese man with a 20-year history of hypertension who presented with normokalemia and normal plasma aldosterone levels. Despite this, laboratory evaluation revealed suppressed direct renin concentration (DRC) and a markedly elevated aldosterone-to-renin ratio (ARR), raising suspicion for PA. Adrenal computed tomography demonstrated bilateral nodular adrenal thickening. The patient had persistently uncontrolled blood pressure despite triple antihypertensive therapy with amlodipine besylate, valsartan/hydrochlorothiazide, and bisoprolol. Spironolactone was added to the existing regimen but was subsequently discontinued due to intolerance. Treatment was then switched to finerenone, a nonsteroidal mineralocorticoid receptor antagonist. During follow-up, blood pressure was well controlled, serum potassium levels remained stable, and both plasma renin concentration and the aldosterone-to-renin ratio normalized.</p><p><strong>Discussion: </strong>This case highlights the diagnostic challenge of PA evaluation in a patient with normal-range aldosterone and suppressed renin and provides clinical experience with finerenone after intolerance to a steroidal mineralocorticoid receptor antagonist.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report. 有其父必有其女:阿莫西林诱发的女患者及其父亲的无菌性脑膜炎一例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-18 DOI: 10.1186/s13256-026-06579-7
Ibrahim Farhood, Sabine Seidel, Maximilian Kaeder, Lars Schönlau, Corinna Seliger
{"title":"Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report.","authors":"Ibrahim Farhood, Sabine Seidel, Maximilian Kaeder, Lars Schönlau, Corinna Seliger","doi":"10.1186/s13256-026-06579-7","DOIUrl":"10.1186/s13256-026-06579-7","url":null,"abstract":"<p><strong>Background: </strong>Drug-induced aseptic meningitis (DIAM) is a neurological disorder that requires specialized diagnostic pathways and an in-depth patient history to prevent inaccurate diagnoses and unnecessary procedures. Amoxicillin has been reported as one of the drugs causing recurrent DIAM, with a total of 22 patients described in the literature.</p><p><strong>Case presentation: </strong>We report two cases involving patients of Mediterranean ethnicity -a father (69-years-old) and his daughter (47-years-old)-who presented to our neurology department at different time points with severe headache persisting for several days. Both patients disclosed recent use of amoxicillin to treat bronchitis and otitis. In both cases, examination of cerebrospinal fluid (CSF) revealed leukocytosis with lymphocytic predominance, while no causative pathogens were identified. After extensive investigations to rule out other causes of secondary headache, a diagnosis of amoxicillin-induced aseptic meningitis (AIAM) was established. Notably, the daughter experienced two similar episodes, both temporally associated with amoxicillin intake.</p><p><strong>Conclusions: </strong>Amoxicillin-induced aseptic meningitis is a rare adverse reaction that should be considered in patients presenting with severe headache in the absence of an identifiable pathogen. A thorough patient history combined with comprehensive diagnostic evaluation is essential to establish the diagnosis and to avoid unnecessary or excessive treatment. Additionally, potential genetic predispositions, as suggested in other forms of drug-induced aseptic meningitis, may play a role and should be considered in selected cases.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying the ICF framework in severe traumatic brain injury: functional profiling to guide multidisciplinary rehabilitation-a case report. 应用ICF框架在严重创伤性脑损伤:功能分析指导多学科康复-一个病例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-17 DOI: 10.1186/s13256-026-06522-w
Dhruvi Chandyoke, Elanthendral Chandrasekar
{"title":"Applying the ICF framework in severe traumatic brain injury: functional profiling to guide multidisciplinary rehabilitation-a case report.","authors":"Dhruvi Chandyoke, Elanthendral Chandrasekar","doi":"10.1186/s13256-026-06522-w","DOIUrl":"10.1186/s13256-026-06522-w","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury is a leading cause of long-term disability and often results in complex physical, cognitive, and psychosocial challenges. Rehabilitation must be individualized and multidisciplinary. This case report demonstrates the application of the International Classification of Functioning, Disability and Health (ICF) framework in developing a comprehensive functional profile, facilitating goal setting, and supporting multidisciplinary rehabilitation planning in severe traumatic brain injury.</p><p><strong>Case presentation: </strong>A 35-year-old South Indian male sustained severe traumatic brain injury and multiple injuries following a road traffic accident. On admission, he presented with deep coma. Neuroimaging revealed bilateral frontal and cerebellar contusions, extradural and subdural hematomas, subarachnoid hemorrhage, cerebral edema, skull fractures, and thoracic injuries. Clinical swallow evaluation indicated severely impaired oral and pharyngeal reflexes. He underwent acute neurosurgical and medical management, followed by a multidisciplinary neurorehabilitation program. Functional assessment using the ICF framework identified deficits in mental functions, neuromusculoskeletal and movement-related functions, sensory functions, swallowing, and activities of daily living. ICF qualifiers guided the formulation of individualized rehabilitation goals addressing arousal, orientation, motor control, communication, swallowing, and daily function. The ICF framework was used to identify impairments, activity limitations, participation restrictions, and environmental factors relevant to rehabilitation planning. The resulting functional profile guided individualized goal setting within the multidisciplinary team. Over, the course of rehabilitation, the patient progressed from a minimally conscious state to achieving basic orientation, oral feeding with compensatory strategies, and functional communication.</p><p><strong>Conclusions: </strong>This case highlights the practical application of the ICF framework in comprehensively profiling functioning and disability following severe traumatic brain injury. The framework facilitated structured assessment, interdisciplinary communication, and individualized goal setting within a multidisciplinary rehabilitation context.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosing Pearson syndrome requires proving a single mtDNA deletion. 诊断皮尔逊综合症需要证明单个mtDNA缺失。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-11 DOI: 10.1186/s13256-026-06600-z
Josef Finsterer
{"title":"Diagnosing Pearson syndrome requires proving a single mtDNA deletion.","authors":"Josef Finsterer","doi":"10.1186/s13256-026-06600-z","DOIUrl":"10.1186/s13256-026-06600-z","url":null,"abstract":"","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALCAPA syndrome: a rare cause of sudden cardiac arrest in adulthood?-a case report. ALCAPA综合征:成人心脏骤停的罕见原因?-一份病例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-09 DOI: 10.1186/s13256-026-06504-y
Carolin Arnoldy, Paul Martin Bansmann
{"title":"ALCAPA syndrome: a rare cause of sudden cardiac arrest in adulthood?-a case report.","authors":"Carolin Arnoldy, Paul Martin Bansmann","doi":"10.1186/s13256-026-06504-y","DOIUrl":"10.1186/s13256-026-06504-y","url":null,"abstract":"<p><strong>Background: </strong>Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare coronary artery anomaly occurring in approximately 1 in 300,000 live births. Typically diagnosed in infancy, ALCAPA can lead to significant cardiovascular complications, including myocardial ischemia, heart failure, and sudden cardiac death if untreated. The adult form of ALCAPA is less common and often identified incidentally through modern cardiac imaging techniques.</p><p><strong>Case presentation: </strong>We describe the case of a 30-year-old white German woman who suffered an out-of-hospital cardiac arrest. Immediate resuscitation was performed, and after successful defibrillation, she was stabilized. Initial hospital assessments, including electrocardiogram (ECG) and echocardiography, showed no abnormalities. However, coronary computed tomography (CT) angiography revealed that the left anterior descending coronary artery (LAD) originated from the pulmonary artery, confirming a diagnosis of ALCAPA. Additionally, an anomaly in the circumflex artery (CX) was discovered, which originated from the right coronary artery (RCA) and ran retroaortically to the lateral wall of the left ventricle. A persistent foramen ovale (PFO) was suspected. Cardiac magnetic resonance imaging (MRI) showed no signs of myocardial scarring. Therefore, additional genetic testing was recommended to evaluate potential non-ischemic causes of the cardiac arrest. The patient underwent successful surgical revascularization of the LAD using the left internal thoracic artery (LIMA) and closure of PFO. Post-surgery, the patient commenced rehabilitation and an implantable cardioverter-defibrillator (ICD) was implanted.</p><p><strong>Conclusion: </strong>This case highlights the complexities in diagnosing and managing ALCAPA in adults. While most patients with ALCAPA present during infancy with heart failure or myocardial ischemia, survival into adulthood without symptoms is rare and depends on the development of extensive collateral circulation. Adult presentation with sudden cardiac arrest in a previously healthy individual is particularly uncommon and poses significant diagnostic challenges. Treatment is typically surgical but must be tailored to the individual, especially in older adults who may benefit from conservative management. This case underscores the importance of interdisciplinary decision-making in the management of ALCAPA to ensure optimal patient outcomes and the importance of advanced cardiac imaging in unexplained cardiac arrest in young adults.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-extubation negative pressure pulmonary edema following acute upper airway obstruction in a young athlete: a case report. 急性上气道阻塞后拔管负压肺水肿一例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-09 DOI: 10.1186/s13256-026-06565-z
Mehdi Oudrhiri Safiani, Hamza Zarouali, Hamza Berrada, Omar Megane, Rim Essaoud, Othmane Sebbata, Bouchra Armel, Rachid El Moussaoui
{"title":"Post-extubation negative pressure pulmonary edema following acute upper airway obstruction in a young athlete: a case report.","authors":"Mehdi Oudrhiri Safiani, Hamza Zarouali, Hamza Berrada, Omar Megane, Rim Essaoud, Othmane Sebbata, Bouchra Armel, Rachid El Moussaoui","doi":"10.1186/s13256-026-06565-z","DOIUrl":"10.1186/s13256-026-06565-z","url":null,"abstract":"<p><strong>Background: </strong>Negative pressure pulmonary edema (NPPE) is a non-cardiogenic hemodynamic pulmonary edema resulting from significant inspiratory effort against obstructed airways. Although rare, it is a recognized cause of postoperative respiratory distress and can mimic differential diagnoses. Patients most predisposed to this condition are muscular or athletic individuals, due to their ability to generate significant negative intrathoracic pressure.</p><p><strong>Case presentation: </strong>An 18-year-old male patient underwent a laparoscopic appendectomy under general anesthesia with tracheal intubation. Two minutes after extubation, the patient developed acute respiratory distress with salmon-pink sputum. Lung auscultation revealed bilateral crackles, associated with desaturation and cyanosis, occurring in the context of acute obstruction of the upper airways during anesthetic awakening. A pleuro-pulmonary ultrasound performed according to the Bedside Lung Ultrasound in Emergency (BLUE) protocol showed a bilateral B-line pattern with preserved pleural sliding. Transthoracic echocardiography showed preserved left ventricular function with non-elevated filling pressures, allowing the rapid exclusion of a cardiogenic origin. Chest radiography demonstrated perihilar alveolar opacities consistent with pulmonary edema. A diagnosis of negative pressure pulmonary edema was thus made. Management consisted of a semi-sitting position at 30°, oxygen therapy, and non-invasive ventilation, without the use of diuretics. Clinical improvement was observed within the first 2 hours, with normalization of blood gases and radiological improvement within 24 hours.</p><p><strong>Conclusion: </strong>Negative pressure pulmonary edema (NPPE) should be considered a cause of post-extubation respiratory distress, particularly in young muscular patients. The integration of pleuro-pulmonary ultrasound and transthoracic echocardiography allows for rapid diagnostic guidance at the patient's bedside. Positive pressure ventilation remains the cornerstone of treatment.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe rise in tacrolimus levels following blood orange and grapefruit juice intake in a kidney transplant recipient: a case report. 肾移植受者血橙和葡萄柚汁摄入后他克莫司水平严重升高:一例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-07 DOI: 10.1186/s13256-026-06514-w
Victoria Östman, Anna-Karin Hamberg, Shinji Yamamoto, Tomas Lorant
{"title":"Severe rise in tacrolimus levels following blood orange and grapefruit juice intake in a kidney transplant recipient: a case report.","authors":"Victoria Östman, Anna-Karin Hamberg, Shinji Yamamoto, Tomas Lorant","doi":"10.1186/s13256-026-06514-w","DOIUrl":"10.1186/s13256-026-06514-w","url":null,"abstract":"<p><strong>Background: </strong>Tacrolimus is a cornerstone immunosuppressant in kidney transplantation with a narrow therapeutic index and high interindividual pharmacokinetic variability, largely determined by CYP3A4, CYP3A5, and P-glycoprotein activity. Grapefruit juice is a known intestinal CYP3A4 inhibitor capable of increasing tacrolimus exposure, whereas blood orange juice has not been documented to exert such effects.</p><p><strong>Case presentation: </strong>A 33-year-old male kidney transplant recipient of Somali origin had persistently low tacrolimus trough levels, averaging about 4.5 µg/L, despite increased dosing. On postoperative day 5 (POD 5), the patient consumed approximately one liter of blood orange juice followed later the same evening by a clinically supervised 250 mL dose of grapefruit juice intended to enhance tacrolimus exposure. The following morning, his tacrolimus concentration had risen sharply sixfold to 30 µg/L, far above the increase typically associated with grapefruit juice alone. Kidney biopsy at that time showed eosinophilic infiltration, consistent with a drug-related inflammatory reaction. Tacrolimus therapy was temporarily stopped, then gradually reintroduced. His condition stabilized, and he was discharged on POD 12.</p><p><strong>Conclusions: </strong>The pronounced increase in tacrolimus exposure following sequential ingestion of blood orange and grapefruit juice suggests a potential synergistic interaction affecting tacrolimus disposition via CYP3A4, CYP3A5 and/or P-glycoprotein pathways. While causality remains unconfirmed, this case emphasizes the value of thorough dietary history in transplant care and supports further research on blood orange juice as a possible modulator of tacrolimus pharmacokinetics.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Residual drugs in the stomach? A case report. 胃里残留药物?一份病例报告。
IF 0.8
Journal of Medical Case Reports Pub Date : 2026-09-05 DOI: 10.1186/s13256-026-06568-w
Shusheng Zhang, Chenhao Wang, Haiyan Song, Zhiwei Chen, Yining Xue, Yikun Zhang, Hongzhu Wen
{"title":"Residual drugs in the stomach? A case report.","authors":"Shusheng Zhang, Chenhao Wang, Haiyan Song, Zhiwei Chen, Yining Xue, Yikun Zhang, Hongzhu Wen","doi":"10.1186/s13256-026-06568-w","DOIUrl":"10.1186/s13256-026-06568-w","url":null,"abstract":"<p><strong>Background: </strong>High-density material identified in the stomach on computed tomography (CT) most commonly represents ingested drugs, oral contrast agents, or blood. Distinguishing between these is critical, as misidentifying drugs or contrast as active gastric bleeding may lead to unnecessary interventions. We report a rare cause of hyperdense gastric material on CT, other than the three etiologies mentioned above.</p><p><strong>Case presentation: </strong>A 25-year-old man with Crohn's disease presented to the gastroenterology department with suspected disease recurrence. At 11:20, a gastroscopy identified an antral ulcer, bile reflux, and a duodenal stricture, through which the gastroscope (approximately 10 mm in width) was able to pass. A subsequent CT enterography performed at 13:49 revealed several round, high-density lesions within the stomach on non-contrast and contrast CT images, which appeared distinct from the surrounding gastric mucosa. While retained oral medication was initially suspected, the patient confirmed he had ingested nothing other than a 2.5% mannitol solution, taken for CT enterography preparation following the gastroscopy. To investigate the composition of these lesions, we combined artificial gastric juice, artificial bile, and 2.5% mannitol in a test tube. This combination yielded a visible precipitate. We therefore conclude that the round lesions observed on CT most likely represent this precipitated material.</p><p><strong>Conclusion: </strong>This case highlights a fourth etiology of high-density gastric material on CT; it is important for radiologists and clinicians to be aware of this situation to prevent misinterpretation of images.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"20 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书