Journal of Medical Case Reports最新文献

{"title":"Hemothorax caused by zone I penetrating neck injury effectively treated with pleural dome laceration covering performed using video-assisted thoracic surgery: a case report.","authors":"Sachie Koike, Takayuki Shiina, Keiichirou Takasuna","doi":"10.1186/s13256-025-05556-w","DOIUrl":"10.1186/s13256-025-05556-w","url":null,"abstract":"<p><strong>Background: </strong>Penetrating neck injuries in the area between the clavicles and the cricoid cartilage sometimes cause intrathoracic problems such as pneumothorax or hemothorax. Injuries of subclavian vessels were reported as a cause of hemothorax caused by penetrating neck injuries. Coil embolization and hemostasis with electrocautery were reported as treatment. Herein we present a case of hemothorax caused by penetrating neck injury, which was treated with pleural dome laceration covering performed using video-assisted thoracic surgery.</p><p><strong>Case presentation: </strong>A 68-year-old Japanese woman presented to our hospital after sustaining a self-inflicted stab wound to her left neck and chest with a kitchen knife. She was in hemorrhagic shock due to hemothorax caused by penetrating neck injury. We performed video-assisted thoracic surgery and stopped bleeding with pleural dome laceration covering. We chose the treatment instead of coil embolization or hemostasis with electrocautery because the bleeding vessel was unclear.</p><p><strong>Conclusion: </strong>Pleural dome laceration covering was effective for hemothorax that was caused by penetrating neck injury when the bleeding vessel was unclear.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"463"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic acute Marjolin ulcer with a short latency period in a young man: a case report.","authors":"Betty Kaitira, Mariam Uledi, Alex Mashaka, Maria Beda, Emmanuel Lugina","doi":"10.1186/s13256-025-05314-y","DOIUrl":"10.1186/s13256-025-05314-y","url":null,"abstract":"<p><strong>Background: </strong>Marjolin ulcer was first mentioned by Celsius in the first century as a malignant transformation of burn scars, which can be caused by chronic wounds. Marjolin ulcer has been observed to have a latent period of over 10 years and occasionally even 36 years, with a small number of reports of short latent periods. Squamous-cell carcinoma (SCC) is the most common histology and is often characterized by an ulcerated wound around the injury site with raised margins. Marjolin ulcer squamous-cell carcinoma's poor vascularity makes it difficult for it to respond to chemotherapy and radiotherapy. There is lack of data on acute Marjolin ulcer related to post-traumatic wounds in sub-Saharan Africa. We are reporting on a rare case of acute Marjolin ulcer squamous-cell carcinoma of the lower limb that was treated at Ocean Road Cancer Institute in Tanzania. The authors sought to enhance awareness of acute Marjolin ulcer in low- and middle-income countries.</p><p><strong>Case description: </strong>This is a case of a 35-year-old male patient of African origin who was working as an agriculture officer and was involved in a motor bicycle traffic accident 6 years prior at the age of 29 years and sustained facial, chest, and right lower limb injuries, which healed by secondary intention 3 months later. A total of 6 months later, he was diagnosed with invasive squamous-cell carcinoma around the lesions in his right knee. The patient was treated with surgery, chemotherapy, and radiotherapy.</p><p><strong>Conclusion: </strong>To our knowledge, this is likely to be the first reported case of acute Marjolin ulcer in East Africa and the third in Africa. This highlights the challenges in diagnosing and managing acute Marjolin ulcer in low- and middle-income countries. The short latent period of acute Marjolin ulcer in Africa necessitates genetic and immunological studies. Where possible, deep chronic wounds should be grafted, while unstable scars should be excised and grafted.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"458"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dieffenbachia plant poisoning requiring mechanical ventilation: a case report and review of the literature.","authors":"Dinberu Oyamo","doi":"10.1186/s13256-025-05388-8","DOIUrl":"10.1186/s13256-025-05388-8","url":null,"abstract":"<p><strong>Background: </strong>Poisoning with Dieffenbachia, a member of the Araceae family, poses serious risks, particularly with respect to oral and airway exposure. This case highlights the critical need for precautionary measures, prompt treatment, and continuous observation following such exposure, emphasizing its significant clinical implications.</p><p><strong>Case presentation: </strong>A 3-year-old Ethiopian boy, who was previously healthy and neurodevelopmentally normal, was brought to the pediatric emergency department after inadvertently chewing and swallowing the parts of Dieffenbachia plant. Initially, he had mild symptoms and signs, including oral and throat irritation and laryngeal and pharyngeal erythema, which were neglected by the parents, leading to respiratory depression, desaturation, seizures, and airway edema on laryngoscope examination. The child's blood counts, renal function, liver enzymes, electrolytes, and blood glucose tests were normal. His case was initially managed in the emergency department with supportive medications, including steroids, antihistamines, acid suppressants, and analgesics. Later, there was a need for immediate intubation and mechanical ventilator support, as the patient developed impending respiratory failure due to upper airway obstruction. The child eventually fully recovered after a few days, with no residual sequelae.</p><p><strong>Conclusion: </strong>It is essential to seek immediate medical attention if individuals are exposed to the toxic Dieffenbachia plant and to closely monitor them for any late symptoms or complications for a minimum of 24 hours, particularly in cases involving the digestive system and airway.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"457"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new tip for early warning of catastrophic antiphospholipid syndrome and hemolysis, elevated liver enzymes, and low platelet count syndrome: a case report.","authors":"Ran Teng, Nan Zheng, Ruixuan Yu, Fengchan Xi","doi":"10.1186/s13256-025-05559-7","DOIUrl":"10.1186/s13256-025-05559-7","url":null,"abstract":"<p><strong>Introduction: </strong>Hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome are severe complications of pregnancy with potentially life-threatening consequences. Currently, the timely recognition and management of pregnant women with hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome remains a challenge.</p><p><strong>Case presentation: </strong>In this case, we describe a 28-year-old East Asian pregnant woman with a history of antiphospholipid syndrome who developed hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome after delivery at 36 weeks of pregnancy. The patient presented with multiple red spots on her extremities and despite receiving conventional therapy, her condition deteriorated rapidly postpartum leading to multiple organ dysfunction syndrome. Notably, the onset of multiple organ dysfunction syndrome occurred within a narrow timeframe of 11 hours.</p><p><strong>Conclusion: </strong>This case underscores the importance of the early warning value of skin manifestations. At the same time, it is crucial to closely monitor pregnant women with antiphospholipid syndrome both during and after delivery. Furthermore, the rapid onset and progression of multiple organ dysfunction syndrome highlight the critical need for prompt initiation of organ support measures in such situations.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"456"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible role of anastrozole-induced hormonal alterations in pathogenesis of mammary apocrine carcinoma and follicular lymphoma: a case report and review of the literature.","authors":"Yukiko Kitagawa, Mehdi Nassiri, Hector Mesa, Jamunabai Prakash, Nikolay Popnikolov","doi":"10.1186/s13256-025-05553-z","DOIUrl":"10.1186/s13256-025-05553-z","url":null,"abstract":"<p><strong>Background: </strong>In postmenopausal women, aromatase inhibitors decrease estrogen levels and increase local dihydrotestosterone concentrations. In this case report, we describe interesting associations between aromatase-inhibitor-induced hormonal changes and the development of apocrine mammary carcinoma and follicular lymphoma.</p><p><strong>Case presentation: </strong>Here we report an 83-year-old Caucasian female patient who initially presented with Paget's disease of the right nipple and associated small focus of invasive ductal carcinoma (ERα + PR + HER2-). The patient did not pursue surgical resection and was treated only with anastrozole, and 5 years later, she was diagnosed with a 1.1 cm ipsilateral periareolar apocrine mammary carcinoma (ERα-ERβ + PR - AR + HER2-) that was detected during surveillance mammography. In addition to this tumor, the subsequent mastectomy specimen revealed an adjacent residual focus of the original invasive ductal carcinoma (ERα + ERβ + PR + AR + HER2-) within the nipple and a focus of follicular lymphoma (ERα-ERβ + AR^low) in the retroareolar area. Sentinel lymph nodes and imaging studies were negative for malignancy. The patient was continued on observation. Anastrozole was stopped after 10 months, and 2 months later, during a routine screening, a 1.8 cm invasive apocrine carcinoma (ERα-ERβ + PR-AR + HER2-) was detected in the patient's contralateral breast and she underwent simple mastectomy with sentinel lymph node biopsy. The sentinel lymph node was negative. No chemotherapy or radiation therapy was recommended. All carcinomas exposed to anastrozole expressed androgen-responsive molecules (GCDFP-15, NKX3.1). Germline genetic testing for 19 genes associated with hereditary breast cancer syndromes was negative, and 3 years later, the patient is still alive with no recurrences.</p><p><strong>Conclusion: </strong>Our case suggests that unopposed local androgen exposure and loss of ERβ-mediated suppressive effect of estrogens may be involved in development of apocrine mammary tumors and lymphomas, respectively. However, further studies are necessary to clarify the roles of steroid hormones in pathogenesis of apocrine carcinoma and follicular lymphoma. This case also illustrates the importance of patient follow-up during and after aromatase inhibitor therapy. Appropriate surveillance for lymphoma may also be considered for those patients. Finally, when lymphoid aggregates are encountered in specimens from patients with breast cancer, a clinical history of hormonal therapy should alert the pathologist for a possibility of lymphoma.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"465"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaplastic carcinoma of breast with heterologous mesenchymal differentiation (carcinosarcoma) having an endothelial component: a case report.","authors":"Shubham Dokania, Lincoln Pujari, Prashanth Giridhar, Abhishek Shinghal, Ankita Rungta Kapoor, Avradeep Datta, Zachariah Chowdhury, Anuj Gupta, Mayank Tripathi, Pritam Mondal, Satyajit Pradhan","doi":"10.1186/s13256-025-05574-8","DOIUrl":"10.1186/s13256-025-05574-8","url":null,"abstract":"<p><strong>Background: </strong>Metaplastic breast cancer with heterologous mesenchymal differentiation, known earlier as carcinosarcoma, consists of both infiltrating ductal carcinoma cells and mesenchymal cells, and is associated with an aggressive course. The mesenchymal component is rarely endothelial, with only two previously reported cases. The present case is the third among those. Moreover, the disease outcome was good, unlike the usual course of carcinosarcoma.</p><p><strong>Case presentation: </strong>A 59-year-old multiparous woman of Indo-aryan ethnicity developed a lump in her left breast and was diagnosed with breast carcinosarcoma having an endothelial component, with the help of histopathological examination and immunohistochemistry. The tumor was surgically removed; then the patient received adjuvant chemotherapy, epirubicin, and cyclophosphamide, followed by adjuvant radiotherapy to the whole breast, followed by tumor bed boost. The patient was clinic-radiologically disease-free even at 26 months post-treatment.</p><p><strong>Conclusion: </strong>Surgery followed by adjuvant chemotherapy and radiotherapy gives better outcomes compared with surgery alone, with a doubtful role of neoadjuvant chemotherapy. Targeted therapies can be considered in patients not responding to conventional treatment.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"470"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-thickness tracheal laceration managed conservatively: a case report.","authors":"Nikita Arora, Maude Rancourt, Mahesh Nagappa, Mehdi Qiabi","doi":"10.1186/s13256-025-05540-4","DOIUrl":"10.1186/s13256-025-05540-4","url":null,"abstract":"<p><strong>Background: </strong>Tracheobronchial injuries, which are rare complications of intubation, can be overlooked without a high degree of clinical suspicion. While traditionally managed surgically, recent literature proposes nonoperative management for low-risk injuries.</p><p><strong>Case presentation: </strong>This case illustrates a 56-year old Caucasian Canadian female with a grade IIIA injury successfully treated conservatively using an endotracheal tube and medical therapy. Consequently, it suggests that nonoperative management may be suitable for patients meeting specific criteria indicative of clinical stability.</p><p><strong>Conclusion: </strong>These insights challenge the conventional surgical approach and emphasize the potential efficacy of conservative measures in selected cases of tracheobronchial injury.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"459"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute isolated fallopian tube torsion in a 37-year-old woman: a case report.","authors":"Abdulaziz Babier, Mohammed Alfaqeh, Joud Makki, Raghad Althobaiti","doi":"10.1186/s13256-025-05527-1","DOIUrl":"10.1186/s13256-025-05527-1","url":null,"abstract":"<p><strong>Background: </strong>Isolated fallopian tube torsion is a rare but critical gynecologic emergency that often presents a diagnostic challenge owing to its nonspecific symptoms and infrequent occurrence. CASE PRESENTATION: This paper discusses the case of a 37-year-old Saudi female who was hospitalized with acute right lower quadrant pain, accompanied by nausea and vomiting. The initial differential diagnosis included ovarian torsion and appendicitis. Diagnostic laparoscopy revealed a right fallopian tube twisted five times, which was later confirmed to be necrotic. Given the irreversible damage to the fallopian tube, a right salpingectomy was performed. The patient recovered well postoperatively and was discharged after 48 h without complications.</p><p><strong>Conclusion: </strong>This case report underscores the importance of considering isolated fallopian tube torsion in the differential diagnosis of acute abdominal pain and highlights the need for prompt surgical intervention to prevent severe complications. The rarity of isolated tubal torsion, normal Doppler findings despite significant torsion, and the surgical management decisions impacting fertility make this case an informative addition to current literature.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"462"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal acute miliary tuberculosis complicated by obstructive jaundice, acute pancreatitis, and hemophagocytic lymphohistiocytosis in a 57-year-old immunocompetent female: a case report.","authors":"Ahed Assaf, Suleiman Khaddour, Saja Karaja, William Borghol, Haya Almohammad, Mario Wassel, Kinan Alkeshk, Akram Shammat","doi":"10.1186/s13256-025-05558-8","DOIUrl":"10.1186/s13256-025-05558-8","url":null,"abstract":"<p><strong>Background: </strong>Miliary tuberculosis occurs in 2% of all patients with tuberculosis when Mycobacterium tuberculosis circulates in the bloodstream, leading to various nonspecific features. Delayed diagnosis and treatment are associated with poor prognosis and outcomes, with complications becoming life-threatening, making management very challenging for clinicians.</p><p><strong>Case presentation: </strong>A 57-year-old immunocompetent Pakistani female presented with nonspecific features, and further investigations yielded a diagnosis of miliary tuberculosis, accompanied by several rare complications, including pancreatitis, obstructive jaundice, acute respiratory distress syndrome, disseminated intravascular coagulation, hemophagocytic lymphohistiocytosis syndrome, and liver failure. Management was challenging, and the patient subsequently died owing to further derangement in liver function.</p><p><strong>Conclusion: </strong>Miliary tuberculosis may present with nonspecific features and symptoms, and a thorough correlation between clinical examination, radiological findings, and laboratory tests is required to establish the diagnosis. The delayed diagnosis and treatment of miliary tuberculosis majorly affect patient outcomes. The progression of the disease is unpredictable, and several complications, although rare, may occur all at once, emphasizing the importance of multidisciplinary collaboration between specialists. Hemophagocytic lymphohistiocytosis symptoms may overlap with miliary tuberculosis symptoms, and antituberculosis therapy medications are irreplaceable in the treatment of tuberculosis-related hemophagocytic lymphohistiocytosis. Immunocompetence is not a basis for excluding miliary tuberculosis.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"466"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced-stage colorectal cancer in the context of coronavirus disease-19, highlighting socioeconomic disparities and outcomes: a case report.","authors":"Hassan Brim, Santiago Gonzales, Mrinalini Deverapalli, Adeyinka O Laiyemo, Mudasir Rashid, Rabia Zafar, Christine Nembhard, Hassan Ashktorab","doi":"10.1186/s13256-025-05409-6","DOIUrl":"10.1186/s13256-025-05409-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This is a case report about how pre-coronavirus disease-19 pandemic health disparities in African Americans with colorectal cancer were compounded and exacerbated by the pandemic's associated delays in screening.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case presentation: &lt;/strong&gt;A 69-year-old African American male patient presented with a primary concern of hematochezia for 1 week. His history revealed multiple risk factors for colorectal cancer, including obesity, diabetes mellitus, and a family history of colorectal cancer in his grandfather. Of note, his father had prostate cancer. On colonoscopy, the patient was found to have a 3-cm fungating, ulcerated, partially obstructing mass in the sigmoid colon, histologically confirmed as well-differentiated adenocarcinoma with mismatch repair proficiency. Imaging studies demonstrated a 2.4-cm hepatic lesion consistent with metastatic disease. Despite a history of benign polyps, removed 10 years earlier, the lack of follow-up colonoscopy led to a delayed diagnosis. The patient was diagnosed with stage IV colorectal adenocarcinoma with hepatic metastases. Initial treatment involved systemic chemotherapy with the folinic acid, fluorouracil, and oxaliplatin regimen to address micrometastatic disease. A laparoscopic hepatectomy and sigmoid colectomy with primary anastomosis was subsequently performed. After surgery, the patient underwent additional chemotherapy with folinic acid, fluorouracil, and oxaliplatin and bevacizumab for 3 months. Despite this, surveillance imaging revealed disease progression within 4 months, including new lung nodules and remnant liver disease. At this stage, therapy was escalated to folinic acid, fluorouracil, and irinotecan and cetuximab owing to the tumor's microsatellite stability and K-RAS/BRAF wild-type status. Unfortunately, the patient's disease progression reflects the aggressive nature of advanced-stage colorectal cancer and highlights the challenges of managing such cases when diagnosis is delayed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This case underscores the critical role of timely colorectal cancer screening and follow-up in preventing late-stage presentations, particularly among African Americans, who already face a disproportionate burden of colorectal cancer incidence and mortality. Socioeconomic barriers, compounded by disruptions during the coronavirus disease-19 pandemic, were key contributors to the patient's delayed diagnosis and subsequent poor outcome. This highlights the need for comprehensive approaches to improve healthcare access, including patient navigation programs, policy changes to expand insurance coverage, and community outreach initiatives to increase awareness about the importance of screening. In addition, early and consistent communication of family cancer history, even involving second-degree relatives, may impact surveillance schedules. This case is also of relevance to the general population as the coronavirus disease-19 pandemic-as","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"467"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}