Journal of Medical Case Reports最新文献

{"title":"Wilson's disease with psychiatric symptoms: a case report.","authors":"Nguyen Van Tuan, Tran Nguyen Ngoc, Nguyen Thuy Hang, Tran My Ha","doi":"10.1186/s13256-025-05486-7","DOIUrl":"10.1186/s13256-025-05486-7","url":null,"abstract":"<p><strong>Background: </strong>Wilson's disease is a copper metabolic disorder defined by the body's accumulation of copper, which inhibits its excretion and initially manifests as liver and neurological symptoms. The patient reported herein showed only psychiatric symptoms and was diagnosed in the latter stages without typical Wilson's disease symptoms. The case underscores the complexity of diagnosing Wilson's disease, emphasizing the significant challenges regarding early detection and treatment efficacy.</p><p><strong>Case presentation: </strong>We report the case of a 20-year-old Vietnamese male with Wilson's disease. The initial manifestations in the patient reported herein include psychiatric symptoms such as mood fluctuations, anger, irritation, impulsivity, emotional eruptions, weariness, and sleep disorders. The patient exhibited no symptoms of Wilson's disease as documented and was diagnosed solely via DNA sequencing, resulting in serious complications and an unfavorable prognosis.</p><p><strong>Conclusions: </strong>This case underscores the complexity of Wilson's disease symptoms. Early identification and effective therapy are crucial for enhancing patient outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"469"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effect of radical debris evacuation with a flexible neuroendoscope on patients with ventriculitis: a case series.","authors":"Takeyoshi Honta, Tomohiro Kawaguchi, Hiroki Uchida, Shunsuke Omodaka, Kuniyasu Niizuma, Hidenori Endo","doi":"10.1186/s13256-025-05541-3","DOIUrl":"10.1186/s13256-025-05541-3","url":null,"abstract":"<p><strong>Background: </strong>Ventriculitis is a severe infectious disease affecting the entire ventricular system and is associated with high mortality and morbidity, particularly due to the subsequent development of hydrocephalus. Although most patients are treated with external ventricular drainage or ventricular irrigation, the impact of radical debris evacuation on clinical outcomes has not been well examined.</p><p><strong>Case presentation: </strong>This study included 11 Japanese patients with ventriculitis treated at Tohoku University Hospital or Kohnan Hospital between January 2000 and December 2020. Of these, eight were male and three were female, with ages ranging from 24 to 88 years (median: 52 years). The following variables were retrospectively analyzed using a computerized neuroendoscopy patient database: age, sex, etiology of ventriculitis, initial ventriculitis treatment, presence of hydrocephalus, and the duration between the initial surgery and additional treatment for hydrocephalus. Among the 11 patients, 6 were treated with external ventricular drainage, while 5 underwent radical debris evacuation with a neuroendoscope. Cerebrospinal fluid diversion surgery for hydrocephalus was required in five of six (83.3%) patients treated with external ventricular drainage and three of five (60%) patients treated with neuroendoscopic debris evacuation. The time interval between the initial treatment for ventriculitis and shunt surgery was significantly shorter in patients who underwent radical debris evacuation (12.7 ± 6.5 days) than in those treated with external ventricular drainage (72.2 ± 52.5 days).</p><p><strong>Conclusion: </strong>Neuroendoscopic radical debris evacuation in patients with ventriculitis may shorten the duration between the initial treatment and shunt surgery and potentially reduce the proportion of patients requiring shunt surgery. This effect is likely due to the attenuation of ventricular inflammation, contributing to improved clinical outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"461"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical subacute thyroiditis mimicking tuberculosis: a case report and review of literature.","authors":"Yembu Ngwengi, Martine Nida, Olive Kamga, Vincent Fonyam","doi":"10.1186/s13256-025-05376-y","DOIUrl":"10.1186/s13256-025-05376-y","url":null,"abstract":"<p><strong>Introduction: </strong>Subacute thyroiditis is a self-limiting condition caused by thyroid inflammation. It usually presents with fever, neck pain and symptoms of thyrotoxicosis. Atypical presentations without neck pain are rare and often lead to misdiagnosis, especially in low-resource settings.</p><p><strong>Case report: </strong>We report a case of atypical subacute thyroiditis in a man of Middle Eastern descent that was initially misdiagnosed as tuberculosis, with lymphoma, painless sporadic thyroiditis, and laryngeal malignancy being differentials. The patient, a 41-year-old male, presented with progressively worsening fevers, night sweats, and weight loss, with thyroid cartilage thickening and tenderness on physical exam. He was diagnosed with subacute thyroiditis through Doppler ultrasound scanning of the thyroid gland, elevated inflammatory markers, and the presence of antibody-negative hyperthyroidism on his biochemical thyroid screen. Symptomatic relief was provided with salicylate and prednisolone. The patient experienced transient asymptomatic hypothyroidism 4 months after disease onset, which was not treated. Euthyroidism was achieved 6 months after symptom onset.</p><p><strong>Conclusion: </strong>Subacute thyroiditis is a rare disease thought to be postviral in origin. It generally presents with fever, neck pain, and signs of thyrotoxicosis and evolves in three phases-a hyperthyroid, hypothyroid, and euthyroid phase. Atypical subacute thyroiditis without neck pain is even rarer; therefore, clinicians should maintain a high index of suspicion for thyroid disorders whenever symptoms suggestive of thyrotoxicosis are encountered, and should always consider thyroid abnormalities when investigating weight loss or persistent fevers in an African setting.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"460"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of finasteride for transgender men with androgenetic alopecia: a case series.","authors":"Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Tomoko Sako, Takatoshi Moriwake, Satoshi Horii, Takuya Sadahira, Satoshi Katayama, Takehiro Iwata, Shingo Nishimura, Kensuke Bekku, Kohei Edamura, Masami Watanabe, Motoo Araki","doi":"10.1186/s13256-025-05562-y","DOIUrl":"10.1186/s13256-025-05562-y","url":null,"abstract":"<p><strong>Background: </strong>Testosterone replacement therapy is commonly used in transgender men for masculinization. One of the most common adverse effects of testosterone replacement therapy is androgenetic alopecia. In Japan, finasteride is approved exclusively for cisgender men and is not indicated for transgender men. The aim of this clinical trial was to evaluate the safety and efficacy of finasteride in transgender men with androgenetic alopecia.</p><p><strong>Case presentation: </strong>This study included three transgender men (assigned female at birth, identifying as male), aged 44, 43, and 29 years. All participants were of Asian ethnicity. A clinical trial was conducted from October 2021 to December 2023. Transgender men aged 20-60 years who had not undergone hysterectomy, were undergoing testosterone replacement therapy, and who had been diagnosed with stage ≥ II androgenetic alopecia on the basis of the Norwood-Hamilton scale were recruited. The participants initiated treatment with 0.2 mg of finasteride per day for 3 months (phase 1). If no adverse events above grade 2 occurred, the dose was increased to 1.0 mg per day for an additional 3 months (phase 2). The primary endpoints were the incidence of treatment-related adverse events at 1 week, 1 month, and 3 months, as well as the rate of participants continuing treatment at 3 months. None of the patients experienced serious adverse events at 3 months, and all the patients extended their treatment to a total of 6 months. Improvements of at least one stage on the N-H scale were observed, but two participants experienced resumption of menstruation.</p><p><strong>Conclusion: </strong>Finasteride appears to be a safe and effective treatment for androgenetic alopecia in transgender men undergoing testosterone replacement therapy. However, its potential for reducing some of the effects of testosterone replacement therapy warrants further investigation.</p><p><strong>Trial registration: </strong>jRCT, jRCTs061210040, registered 7 October 2021, https://jrct.mhlw.go.jp/latest-detail/jRCTs061210040 .</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"468"},"PeriodicalIF":0.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cardiac endosarcoma: a case report.","authors":"Shishi Zhong, Yanhong Luo, Yunxia Fei, Siyu Zhang","doi":"10.1186/s13256-025-05538-y","DOIUrl":"10.1186/s13256-025-05538-y","url":null,"abstract":"<p><strong>Background: </strong>Primary cardiac intimal sarcoma is an exceptionally rare and aggressive malignancy, representing a small subset of primary cardiac tumors. Owing to its rapid progression and limited treatment options, the median survival is typically less than 1 year. We report a rare case of primary cardiac intimal sarcoma with MDM2 amplification, in which the patient achieved survival exceeding 1 year through a multimodal treatment approach, offering valuable insights into the management of this highly lethal disease.</p><p><strong>Case presentation: </strong>A 48-year-old previously healthy Han Chinese woman presented with progressive chest tightness, dyspnea, and hemoptysis. Imaging revealed a large, irregular mass (64 × 41 mm) in the left atrium, partially prolapsing into the left ventricle. Elevated serum tumor markers were noted. The patient underwent surgical resection under cardiopulmonary bypass, and histopathological examination confirmed intimal sarcoma with MDM2 gene amplification. The diagnosis is: primary cardiac endosarcoma. Despite postoperative recurrence within the left ventricle, sequential therapies were implemented, including liposomal doxorubicin, oral anlotinib, and combined chemotherapy with gemcitabine and docetaxel plus anlotinib. The tumor initially showed progression but subsequently demonstrated partial regression following therapy adjustments. The patient has remained clinically stable for over 1 year post-diagnosis under ongoing treatment.</p><p><strong>Conclusion: </strong>This case highlights the extreme rarity and poor prognosis of primary cardiac intimal sarcoma and demonstrates that combining surgery, chemotherapy, and targeted therapy may contribute to prolonged survival. These findings suggest the potential role of anlotinib-based therapy for managing MDM2-amplified cardiac intimal sarcoma and warrant further clinical investigation.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"447"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequate hemodialysis does not compromise the cardioprotective effect of agalsidase alfa on patients with Fabry disease: a case report.","authors":"Xiansen Wei, Shimin Jiang, Li Zhuo, Hong Jiang, Wenge Li","doi":"10.1186/s13256-025-05488-5","DOIUrl":"10.1186/s13256-025-05488-5","url":null,"abstract":"<p><strong>Background: </strong>Fabry disease is an inherited lysosomal storage disease that can be reversed, or the progression slowed, by enzyme replacement therapy in the early stage. However, whether patients receiving renal replacement therapy benefit from enzyme replacement therapy remains controversial, especially in regard to patients on hemodialysis, who additionally suffer from uremia and abnormal hemodynamics.</p><p><strong>Case presentation: </strong>Two male Han Chinese patients diagnosed with uremia prior to Fabry disease underwent renal transplantation and hemodialysis, respectively. At the ages of 27 and 32 years, they began receiving agalsidase-α, an enzyme replacement therapy drug, in February 2022, lasting for 1.5 years. Cardiac structural and functional parameters were obtained using the 6-minute walk test, along with serum biomarkers and electrocardiogram and ultrasound examinations. Changes in the cardiac parameters and the plasma globotriaosylsphingosine concentration before and after enzyme replacement therapy were evaluated. Both patients received enzyme replacement therapy for 18 months, which was uneventful. One patient maintained normal renal function, while the other received adequate dialysis. The level of globotriaosylsphingosine was reduced by approximately two-thirds after the first 3-month enzyme replacement therapy and remained stable during follow-up. No significant changes were detected in cardiac structure or function parameters, with the exception of the PR interval and left atrial reservoir strain. The PR interval of the renal transplant patient was prolonged from 108 to 128 milliseconds. Left atrial reservoir strain improved significantly in both patients, from 29.4% to 53.1% and from 46.3% to 59.3%, respectively.</p><p><strong>Conclusion: </strong>Patients with Fabry disease who are on renal replacement therapy may benefit from enzyme replacement therapy. Moreover, adequate hemodialysis does not compromise the cardioprotective effect of agalsidase-α.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"453"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected occurrence of anti-B antibodies in a patient with A2B blood group: a case report and review of literature.","authors":"Fatemeh Kalhori, Masoumeh Babakhani, Mohammad Sayyadi","doi":"10.1186/s13256-025-05535-1","DOIUrl":"10.1186/s13256-025-05535-1","url":null,"abstract":"<p><strong>Background: </strong>The ABO blood group system categorizes human blood according to the inherited characteristics of erythrocytes, which are defined by the presence or absence of antigens A and B located on the surface of red blood cells. In the absence of these antigens, the body produces natural antibodies.</p><p><strong>Case presentation: </strong>In this case report, we present a 42-year-old man of Iranian (Persian) ethnicity who was a blood donor at the Arak transfusion center. Forward and reverse typing showed a discrepancy, with AB as the cell type and O blood group as the back type results.</p><p><strong>Conclusion: </strong>This report shares our experience of unexpected anti-A and anti-B antibodies presence in AB blood group. Finally, it was discovered that the patient has an A2B blood group with clinically insignificant anti-A1 antibodies. The reason behind the occurrence of B antibodies in this case is still unknown but can be considered an acquired B phenomenon. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A2B blood type in Iran.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"446"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of ectrodactyly-associated foot deformity in a child: a case report.","authors":"Sohaib Raza, Shahrukh Rehman, Zernain Toor, Risha Naeem, Soban Ahmed Qureshi, Muzzamil Ahmed, Tehreem Zubair, Samim Noori, Sardar Noman Qayyum","doi":"10.1186/s13256-025-05389-7","DOIUrl":"10.1186/s13256-025-05389-7","url":null,"abstract":"<p><strong>Background: </strong>Ectrodactyly, also called split hand/foot malformation, is a rare birth defect where some middle fingers or toes are missing or not formed properly, making the hand or foot look split. This condition can happen on its own or as part of more complicated syndromes such as ectrodactyly-ectodermal dysplasia-cleft syndrome. Surgery for young patients is usually tailored to their specific needs on the basis of how much the condition affects their ability to function and their appearance.</p><p><strong>Case presentation: </strong>In this manuscript, we reported a case of a Punjabi 6-year-old female presenting with difficulty in walking and an abnormal appearance of her left foot since birth. The clinical examination revealed the congenital absence of the second and third toes, syndactyly between the first and fourth digits, and a bony protrusion on the dorsum of the foot. The patient's radiological evaluation confirmed the absence of corresponding metatarsals and phalanges. The patient underwent a ray amputation of the first and fourth digits, along with the removal of the ectopic phalanx. The surgical procedure resulted in improved weight-bearing and cosmetic appearance. On the third postoperative day, the patient was discharged, and she demonstrated satisfactory healing and ambulation during follow-up.</p><p><strong>Conclusion: </strong>This case highlights the surgical management of a rare foot deformity associated with ectrodactyly in a child. Ray amputation proved to be a functional and aesthetically acceptable approach. Early recognition and tailored interventions are crucial for optimizing the patient outcomes in congenital limb anomalies.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"452"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydatid cyst of the neck presenting with left upper limb paresthesia in a 29-year-old man: a case report.","authors":"Jalal Rezaei, Hossein Gandomkar, Ehsan Chenarani, Zahra Moghimi, Ehsan Sobhanian","doi":"10.1186/s13256-025-05523-5","DOIUrl":"10.1186/s13256-025-05523-5","url":null,"abstract":"<p><strong>Background: </strong>Hydatid disease (echinococcosis) is a parasitic infection caused by Echinococcus species, commonly involving the liver and lungs. Cervical hydatid cysts are exceptionally rare, even in endemic regions, accounting for less than 1% of cases. Clinical presentation often mimics other benign neck masses, making early diagnosis challenging. Neurological manifestations due to mass effect on neural structures are exceedingly uncommon.</p><p><strong>Case presentation: </strong>We report a rare case of a 29-year-old Iranian man presenting with a 2-week history of progressive left-sided neck swelling and associated paresthesia in the left upper limb. Physical examination revealed a firm, mobile mass in the left posterior triangle of the neck. Neurological examination showed decreased sensation in the C5-C6 dermatome. Imaging studies revealed a simple cystic lesion adjacent to the left carotid sheath. Surgical excision confirmed a hydatid cyst compressing the brachial plexus. Histopathology supported the diagnosis. The patient experienced full resolution of neurological symptoms within 2 months postoperatively, and no recurrence was noted at 1-year follow-up. Albendazole therapy was continued for 2 months post-surgery.</p><p><strong>Conclusion: </strong>To our knowledge this is the second documented case of a cervical hydatid cyst presenting with neurological symptoms due to brachial plexus compression. It underscores the importance of considering hydatid disease in the differential diagnosis of neck masses, particularly in endemic areas or among individuals with livestock exposure. Prompt surgical intervention combined with antiparasitic therapy is essential for a favorable outcome.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"445"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced eumycetoma with intracranial extension in three Sudanese patients: a case series and review of the literature.","authors":"Mohamed Soud Saadeldein, Mohamed Daffalla Awadalla Gismalla, Mustafa Yousif Altahir Alnkhly","doi":"10.1186/s13256-025-05443-4","DOIUrl":"10.1186/s13256-025-05443-4","url":null,"abstract":"<p><strong>Background: </strong>Eumycetoma is an endemic chronic granulomatous infection in tropical and subtropical regions, including Sudan.</p><p><strong>Case presentation: </strong>This case series presents three Sudanese patients with intracranial mycetoma (27-year-old female from Central Sudan, 20-year-old male from Central Sudan, and 23-year-old male from West Sudan), highlighting different clinical presentations, diagnostic challenges, and management strategies. All cases involved young individuals with painless swellings, discharging sinuses, and other central nervous system manifestations. The diagnosis was confirmed by different histopathological and imaging modalities. Surgical management was performed for the localized lesion case but, unfortunately, the other two cases were difficult to operate on owing to the large extension of the disease and were followed with medical management.</p><p><strong>Conclusion: </strong>This series highlights the difficulties in diagnosing and managing cases of intracranial mycetoma. It emphasizes the importance of early diagnosis, multidisciplinary management, and public health efforts to reduce the burden of mycetoma in endemic regions.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"451"},"PeriodicalIF":0.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}