Journal of Medical Case Reports最新文献

{"title":"Transient osteoporosis of the hip in a 17-year-old nonpregnant female: a case report.","authors":"Abdirizak Abdullahi Sheikdon, Abdishakur Mohamud Ahmed, Omar Hassan Ahmed","doi":"10.1186/s13256-025-05381-1","DOIUrl":"10.1186/s13256-025-05381-1","url":null,"abstract":"<p><strong>Background: </strong>Transient osteoporosis of the hip is a rare, self-limiting condition that typically affects middle-aged men and pregnant women in the third trimester. It is rarely observed in adolescents.</p><p><strong>Case report: </strong>We present a unique case of transient osteoporosis of the hip in a 17-year-old Somali nonpregnant female who reported severe left hip pain and restricted mobility. Initial investigations revealed bone marrow edema on magnetic resonance imaging and deficiencies in phosphorus and magnesium. The patient was treated conservatively with bed rest, nutritional supplementation, bisphosphonates, and corticosteroids. This comprehensive approach led to significant improvement. At follow-up, the patient demonstrated complete resolution of symptoms and normalization of imaging findings.</p><p><strong>Conclusion: </strong>This case underscores the importance of early diagnosis and targeted therapy in achieving full recovery from transient osteoporosis of the hip. Furthermore, it expands the demographic spectrum of transient osteoporosis of the hip, emphasizing its occurrence in nonpregnant adolescents.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"323"},"PeriodicalIF":0.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dowling-Degos disease in a 23-year-old Jordanian male: a case report.","authors":"Hamdah Hanifa, Aya Mohannad Hamdan, Ansam Zakaria Baniamer, Jihan Mohammed Muhaidat, Sultan Hussein Al-Sahoud, Mohammad Raed AlGhzawi, Mohammad Tareq Alfaqeh","doi":"10.1186/s13256-025-05398-6","DOIUrl":"10.1186/s13256-025-05398-6","url":null,"abstract":"<p><strong>Background: </strong>Dowling-Degos disease is a rare genodermatosis disorder that presents as an autosomal dominant trait during late childhood or in adolescence and is also known as reticulate pigmented anomaly of flexures, Dowling-Degos-Kitamura, or dark dot disease. Dowling-Degos disease is characterized by acquired reticular hyperpigmentation, and manifests as a clustered or reticulated pattern mainly at flexural sites, especially in the folds of the skin with comedone-like follicular papules and pitted perioral scars. It appears in both genders but is more likely in females.</p><p><strong>Case presentation: </strong>A 23-year-old Jordanian male presented with progressive hyperpigmented macules and papules on his forehead, initially managed with Triderma cream without improvement. Histopathological examination via punch biopsies revealed features consistent with Dowling-Degos disease, excluding malignancy. Treatment was transitioned to sunblock, depigmenting agents (Isis Unit One 4 White), and moisturizers, resulting in significant fading of lesions after 8 months. Genetic counseling was provided owing to the hereditary nature of Dowling-Degos disease, and long-term management strategies were emphasized.</p><p><strong>Conclusion: </strong>Dowling-Degos disease is a rare genodermatosis that can cause significant psychological distress and a decline in quality of life. Despite challenging treatment, a multidisciplinary approach is essential for improving patient outcomes and managing the elevated risk of skin cancers.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"322"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom improvement in a South Asian patient with Parkinson's disease treated with immediate- and extended-release carbidopa-levodopa: a case report.","authors":"Gail Reiner, Michael Skipworth","doi":"10.1186/s13256-025-05385-x","DOIUrl":"10.1186/s13256-025-05385-x","url":null,"abstract":"<p><strong>Background: </strong>Little is reported in literature about Parkinson's disease and treatment responses among South Asians.</p><p><strong>Case presentation: </strong>Under the supervision of a movement disorders neurologist, an 85-year-old South Asian American man in hospice care was sufficiently regenerated from an adjustment of medications for Parkinson's disease, such that he was able to shift from being immobile, unable to speak, or safely eat and drink fluids orally, to walking, eating, drinking fluids, and communicating again. His initial symptoms motivated him to seek neurological care in 2012, with his first consultation with a movement disorders neurologist occurring in 2023. After receiving specialty care and adjusting his carbidopa-levodopa from immediate release to a combination short- and long-acting formulation, Rytary, he was discharged from hospice to home health care. He progressed from being almost entirely nonverbal, bed-bound, and solely dependent on artificial nutrition to supportive home-based physical therapy, which facilitated his ability to regain sufficient strength for ambulation, eating and drinking orally, and he can once again use expressive language.</p><p><strong>Conclusion: </strong>Immediate-release carbidopa-levodopa given three to four times daily remains the most common medication regimen for managing Parkinson's disease symptoms of tremor and rigidity, with benefits noted in responsive patients for 2 to 3 hours. Extended release and combination formulations of carbidopa-levodopa that combine short- and long-acting medications in one capsule provide symptom relief for responsive patients for 4-6 hours and should be considered when the benefit from immediate-release carbidopa-levodopa is limited. Little has previously been published about the potential for variations in carbidopa-levodopa formulation responsiveness in South Asians, though it has been suggested that Western guidelines for managing \"off\" periods where carbidopa-levodopa is less effective, may not apply to other ethnicities (Bhidayasiri et al. in Expert Rev Neurother 15(11):1285-1297, 2015). As exemplified in this case, greater understanding of non-Caucasian races' responses to carbidopa-levodopa, extended release, and their combination formulas is needed as is the benefit from subspecialty care within neurology, where the art of medication management is enhanced by experience in movement disorders and where objective tools such as the Movement Disorder Society-Unified Parkinson's Disease Rating Scale can measure stability, decline, or improvement within each patient pertaining to their activities of daily living, cognitive and motor functions impacted by Parkinson's disease, as well as monitoring for adverse reactions to medications used for Parkinson's disease, such as dyskinesias.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"321"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of severe leptospirosis complicated with massive rhabdomyolysis and acute kidney injury: a case report.","authors":"Milad Badri, Negar Sheikhdavoodi, Farhad Nikkhahi, Aida Vafae Eslahi, Panagiotis Karanis","doi":"10.1186/s13256-025-05378-w","DOIUrl":"10.1186/s13256-025-05378-w","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis is a reemerging waterborne zoonotic infection with a significant global health importance. The manifestations are ranged from mild febrile illness to severe conditions, including Weil's disease and rhabdomyolysis-induced acute kidney injury.</p><p><strong>Case presentation: </strong>Here we report a case of a 27-year-old Iranian male patient with a history of mountain climbing who developed severe leptospirosis. The patient presented massive rhabdomyolysis, acute kidney injury, and respiratory distress, initially suspected to be related to his physical activity. The leptospirosis infection was confirmed using an enzyme-linked immunosorbent assay. Despite hydration and broad-spectrum antibiotic therapy, the patient's condition demanded intensive care and hemodialysis. Finally, the patient recovered completely, underscoring the critical need for timely diagnosis and intervention in leptospirosis cases. To date, there have been no reports of leptospirosis-associated rhabdomyolysis in Iran. Additionally, cases of rhabdomyolysis caused by leptospirosis are rare worldwide.</p><p><strong>Conclusion: </strong>This is report reveals the reemergence of leptospirosis, particularly in environments conducive to the survival of Leptospira bacteria, and the significance of awareness and preventive measures, especially for susceptible populations.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"316"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation in a large broad ligament leiomyoma: a case report.","authors":"Jouni Aljoudeh, Ali Deeb, Yahia Ranjous, Mari Alahmad, Sarah Al Haj Diab, Aimar Abo Moughdeb, Dema Adwan","doi":"10.1186/s13256-025-05384-y","DOIUrl":"10.1186/s13256-025-05384-y","url":null,"abstract":"<p><strong>Background: </strong>Uterine leiomyomas (uterine fibroids) are the most common tumors of the uterus. Extrauterine fibroids are rare, with the broad ligament being the most common location. Fibroids are usually asymptomatic. Some common symptoms include menstrual disturbances, a sensation of heaviness, and urinary issues.</p><p><strong>Case presentation: </strong>A 27 year-old Syrian woman presented with lower abdominal pain that had persisted for a year. Her last delivery was 9 months prior. Ultrasound imaging revealed a 10 cm × 15 cm heterogeneous mass extending from the right iliac region to the umbilical region. The mass was surgically resected, with preservation of the uterus and adnexa. Histopathological examination confirmed the diagnosis as leiomyoma with hyaline degeneration.</p><p><strong>Conclusion: </strong>Leiomyomas, typically located in the uterus, can also occur in extrauterine locations such as the broad ligament. The diagnosis and management of extrauterine fibroids are challenging owing to their rarity and rich vascularity of the surrounding tissue, especially in patients wishing to preserve fertility.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"318"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral joint infection caused by Salmonella: a post-gastroenteritis complication-a case report.","authors":"Mario Cahueque, Enrique Azmitia, Ramirez Claudio","doi":"10.1186/s13256-025-05144-y","DOIUrl":"10.1186/s13256-025-05144-y","url":null,"abstract":"<p><strong>Background: </strong>Septic arthritis of the sacroiliac joint is an uncommon condition, accounting for only 1-2% of all septic arthritis cases. Its rarity, coupled with a nonspecific clinical presentation, often leads to diagnostic delays. While Staphylococcus aureus is the most common pathogen, Salmonella species are rare etiological agents, typically associated with specific risk factors. This case highlights the novelty of a Salmonella enteritidis-induced septic sacroiliitis in a previously healthy adolescent of Ladino ethnicity, emphasizing the importance of considering atypical pathogens.</p><p><strong>Case presentation: </strong>A 17-year-old Ladino male presented with severe lower back and buttock pain radiating to the left leg, 1 week after recovering from a gastrointestinal illness. Laboratory findings revealed elevated inflammatory markers, and imaging showed significant inflammation of the left sacroiliac joint. Diagnosis was confirmed via joint fluid aspiration, which identified S. enteritidis. The patient was treated with intravenous ceftriaxone and amikacin, transitioning to oral antibiotics for 6 weeks. Symptoms resolved within 72 hours of treatment initiation, with full recovery of mobility and sustained symptom-free status at 1-year follow-up.</p><p><strong>Conclusion: </strong>This case underscores the importance of timely diagnosis and tailored treatment for septic sacroiliitis caused by atypical pathogens. It also highlights the need to consider Salmonella in patients presenting with sacroiliac joint pain and a recent history of gastrointestinal infection, even in the absence of traditional risk factors, ensuring optimal clinical outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"315"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of mediastinal teratoma and intrapulmonary bronchogenic cyst: a case report.","authors":"Sepehr Sadrizadeh, Ali Sadrizadeh, Mohammad Hadi Sadeghian","doi":"10.1186/s13256-025-05391-z","DOIUrl":"10.1186/s13256-025-05391-z","url":null,"abstract":"<p><strong>Background: </strong>Mediastinal masses are relatively common in pediatric populations, but their coexistence with bronchogenic cysts is extremely rare. Such cases present diagnostic and therapeutic challenges owing to overlapping features and the need for precise identification to guide appropriate management. Reporting this unusual combination enhances awareness and contributes to the understanding of their clinical presentation and treatment.</p><p><strong>Case presentation: </strong>A 15-year-old female of Iranian ethnicity presented with a 3-month history of persistent, nonproductive cough unresponsive to standard medical treatments. The patient had no significant past medical history. Diagnostic imaging, including chest X-ray and computed tomography scans, revealed two separate thoracic lesions suggestive of mediastinal and pulmonary masses. The patient also underwent surgical resection via left posterolateral thoracotomy. Histopathological examination confirmed a mature cystic teratoma in the mediastinum, containing various tissue types, and an infected bronchogenic cyst within the lung, characterized by alveolar hemorrhage and abscess formation. Postoperative recovery was uneventful, and follow-up imaging demonstrated no residual abnormalities.</p><p><strong>Conclusion: </strong>This case revealed the importance of comprehensive diagnostic evaluation in pediatric patients with persistent respiratory symptoms. Although rare, the simultaneous occurrence of mediastinal mature teratomas and bronchogenic cysts should be considered in differential diagnoses to enable timely surgical intervention. Recognizing this coexistence can lead to favorable outcomes and informs clinicians about the potential complexity of thoracic masses in adolescents.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"320"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timely diagnosis of emphysematous pyelitis by point-of-care ultrasound in an outpatient setting prevented infection spread: a case report and review of the literature.","authors":"Octavio J Salgado, Angela M Vidal, Abhilash Koratala, Zoila K Salazar-Torres, Hermel M Espinosa","doi":"10.1186/s13256-025-05361-5","DOIUrl":"10.1186/s13256-025-05361-5","url":null,"abstract":"<p><strong>Background: </strong>Emphysematous pyelitis represents the initial stage of emphysematous pyelonephritis, a rare and potentially life-threatening necrotizing renal infection caused by gas-forming bacteria. Diabetes mellitus and/or lithiasis constitute significant risk factors for such conditions. Renal point-of-care ultrasound is an invaluable diagnostic tool for the early detection of gas within the kidney and urinary tract. The present case provides an illustrative example of the crucial importance of routinely using renal point-of-care ultrasound in every patient with a suspected urinary tract infection in an outpatient setting.</p><p><strong>Case presentation: </strong>A 55 year-old hypertensive, non-diabetic female patient of Wayuu indigenous ethnicity was evaluated for mild-to-moderate right flank pain accompanied by slight fever at night. She was referred to the renal outpatient clinic with a presumptive urinary tract infection. In the context of a systemic review for symptoms, the patient reports expulsion of gas bubbles during urination. She was evaluated by ultrasound, which detected gas in the pyelocaliceal system. A computed tomography scan confirmed this. The patient was admitted to the hospital and started on intravenous therapy with ceftriaxone. Urine culture revealed the presence of E. coli > 100 CFU sensitive to ceftriaxone. The response to antibiotherapy was favorable, with remission of clinical symptoms and moderate leukocytosis observed at the time of admission.</p><p><strong>Conclusion: </strong>Routine point-of-care ultrasound evaluation should be part of the physical evaluation of every patient presenting with a suspected upper urinary tract infection in the renal outpatient clinic.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"319"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel sequence of the PHKG2 mutation associated with the first case of glycogen storage diseases type IXc in Syria: a case report and review of literature.","authors":"Seba Harh, Shaza Shahoud, Shady Daher, Diana Alasmar","doi":"10.1186/s13256-025-05383-z","DOIUrl":"10.1186/s13256-025-05383-z","url":null,"abstract":"<p><strong>Background: </strong>Glycogen storage diseases are a group of inherited metabolic disorders that affect the body's ability to break down and/or store glycogen. Type IX glycogen storage disease is an inherited disorder caused by a deficiency of phosphorylase kinase, which leads to various symptoms. We report the first reported case in Syria of glycogen storage disease type IXc caused by a novel phosphorylase B kinase catalytic subunit gamma 2 gene mutation, emphasizing the importance of early diagnosis and genetic counseling.</p><p><strong>Case presentation: </strong>A 6-month-old Syrian male infant of Arab ethnicity presented with developmental delay, hepatomegaly, and hypoglycemia. Genetic testing identified a previously unreported phosphorylase B kinase catalytic subunit gamma 2 variant (c.801G > A p.( =)), classified as a variant of uncertain significance. Liver biopsy and clinical features were consistent with glycogen storage disease type IXc.</p><p><strong>Discussion: </strong>This report expands the current understanding of phosphorylase B kinase catalytic subunit gamma 2-related glycogen storage disease type IXc by documenting a novel synonymous mutation with potential clinical significance. It underscores the critical role of early genetic testing in consanguineous populations, not only for accurate diagnosis but also for guiding family counseling and long-term management.</p><p><strong>Conclusion: </strong>The identification of this novel mutation contributes to expanding the known phosphorylase B kinase catalytic subunit gamma 2 mutation spectrum and stresses the need for genetic counseling in similar populations.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"317"},"PeriodicalIF":0.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent giant retroperitoneal dedifferentiated liposarcoma requiring challenging multiorgan resection: a case report.","authors":"Cesar Prugue, Emma Bao, Camden Pereira, Bing Yi","doi":"10.1186/s13256-025-05379-9","DOIUrl":"10.1186/s13256-025-05379-9","url":null,"abstract":"<p><strong>Background: </strong>Dedifferentiated liposarcoma is a rare, aggressive subtype of liposarcoma known for its high recurrence rate and local invasiveness. This case demonstrates the challenges in managing a rapidly recurring dedifferentiated liposarcoma and underscores the need for improved surveillance and additional treatment options.</p><p><strong>Case presentation: </strong>A 57-year-old non-Hispanic white male presented in November 2023 with a 2-month history of intermittent fevers, nonproductive cough, and lower abdominal discomfort. Imaging revealed a 12 cm × 12 cm × 16 cm retroperitoneal mass, confirmed to be a high-grade dedifferentiated liposarcoma. Initial surgical resection in December 2023 removed the tumor, which was densely adhered to the left kidney. Despite adjuvant chemotherapy, follow-up imaging in July 2024 showed tumor recurrence with a 15 cm × 14 cm × 21 cm multiloculated cystic mass extending from the spleen to the lower pole of the kidney, as well as a 12 cm × 6 cm × 15 cm mass inferior to the left kidney. Owing to the extensive local invasion, a second surgery in August 2024 required a left nephrectomy, splenectomy, hemicolectomy, and distal pancreatectomy. The tumor's proximity to the abdominal aorta and invasion into the psoas muscle posed significant surgical challenges, requiring careful resection.</p><p><strong>Conclusion: </strong>This case highlights the aggressive nature of high-grade dedifferentiated liposarcoma and its resistance to chemotherapy. Surgical resection remains the primary treatment option, but the recurrence emphasizes the need for more effective therapies. The case further illustrates the complexity of multiorgan involvement in recurrent dedifferentiated liposarcoma and the critical role of experienced oncologic surgeons in managing these cases. More research is necessary to develop alternative treatments that can better control tumor progression and improve patient outcomes.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"313"},"PeriodicalIF":0.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}