Fatemeh Kalhori, Masoumeh Babakhani, Mohammad Sayyadi
{"title":"Unexpected occurrence of anti-B antibodies in a patient with A2B blood group: a case report and review of literature.","authors":"Fatemeh Kalhori, Masoumeh Babakhani, Mohammad Sayyadi","doi":"10.1186/s13256-025-05535-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The ABO blood group system categorizes human blood according to the inherited characteristics of erythrocytes, which are defined by the presence or absence of antigens A and B located on the surface of red blood cells. In the absence of these antigens, the body produces natural antibodies.</p><p><strong>Case presentation: </strong>In this case report, we present a 42-year-old man of Iranian (Persian) ethnicity who was a blood donor at the Arak transfusion center. Forward and reverse typing showed a discrepancy, with AB as the cell type and O blood group as the back type results.</p><p><strong>Conclusion: </strong>This report shares our experience of unexpected anti-A and anti-B antibodies presence in AB blood group. Finally, it was discovered that the patient has an A2B blood group with clinically insignificant anti-A1 antibodies. The reason behind the occurrence of B antibodies in this case is still unknown but can be considered an acquired B phenomenon. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A2B blood type in Iran.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"446"},"PeriodicalIF":0.8000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465467/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13256-025-05535-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The ABO blood group system categorizes human blood according to the inherited characteristics of erythrocytes, which are defined by the presence or absence of antigens A and B located on the surface of red blood cells. In the absence of these antigens, the body produces natural antibodies.
Case presentation: In this case report, we present a 42-year-old man of Iranian (Persian) ethnicity who was a blood donor at the Arak transfusion center. Forward and reverse typing showed a discrepancy, with AB as the cell type and O blood group as the back type results.
Conclusion: This report shares our experience of unexpected anti-A and anti-B antibodies presence in AB blood group. Finally, it was discovered that the patient has an A2B blood group with clinically insignificant anti-A1 antibodies. The reason behind the occurrence of B antibodies in this case is still unknown but can be considered an acquired B phenomenon. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A2B blood type in Iran.
期刊介绍：
JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
