Journal of lasers in medical sciences最新文献

{"title":"Laser-Based Rejuvenation of the Upper Airway: A Novel Non-Surgical Approach to Habitual Snoring.","authors":"Rohit Kothari, Rohan Manoj, Asharbh Raman, Shubham Deokar, Vishavjit Singh, Aayush Gupta","doi":"10.34172/jlms.51118","DOIUrl":"10.34172/jlms.51118","url":null,"abstract":"<p><p><b>Introduction:</b> This study aimed to evaluate the efficacy of Erbium-Doped Yttrium Aluminium Garnet (Er: YAG, 2940 nm), combined with a long-pulse Nd: YAG laser, in mitigating habitual snoring. <b>Methods:</b> Thirty patients participated in the single-arm prospective study, receiving approximately 20,000 pulses of the Er: YAG laser directed at the target sites using a patterned beam from the PSO3X handpiece in Long Pulse (LP) mode, followed by long-pulse Nd: YAG irradiation of the submental and lateral neck region. Treatments were administered on days 0, 15, and 45. The treatment response was evaluated through subjective methods, including the Snore Outcomes Survey (SOS) and the Spouse/Bed Partner Survey (SBPS). Anatomical enhancement was assessed using the Mallampati classification before each session and nine months subsequent to the final session. <b>Results:</b> The mean Mallampati class decreased from 3.50±0.68 to 2.43±0.73. Statistically significant alterations were observed in the SOS and SBPS scores, which increased from 47.10±11.34 to 66.22±11.18 and from 44.38±16.22 to 63.11±14.64, respectively. Older age showed a borderline correlation with the Mallampati class, whereas weight and BMI did not; patients with lower baseline SOS scores tended to improve more. <b>Conclusion:</b> In this single-arm pilot study, the combined Er: YAG and Nd: YAG protocol was well tolerated and was associated with improvements in habitual snoring; controlled trials are required to confirm its efficacy in the early management of snoring.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51118"},"PeriodicalIF":1.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Carbon-Based Nanomaterials on Antimicrobial Photodynamic Therapy (aPDT).","authors":"Marjan Salehimanesh, Fedora Khatibi Shahidi, Afshan Shirkavand, Shaghayegh Nasr","doi":"10.34172/jlms.51974","DOIUrl":"10.34172/jlms.51974","url":null,"abstract":"<p><p><b>Introduction:</b> The escalating global burden of antimicrobial resistance (AMR) and persistent biofilm-associated infections has created an urgent need for novel therapeutic strategies. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising, resistance-independent approach capable of generating reactive oxygen species (ROS) to damage multiple cellular targets. <b>Methods:</b> This review synthesizes recent advances in the application of carbon-based nanomaterials-including carbon quantum dots (CQDs), graphene quantum dots (GQDs), porphyrin-carbon hybrids, and related nanocomposites-to enhance the efficacy of aPDT against bacterial pathogens and biofilms. <b>Results:</b> Carbon quantum dots demonstrate potent photosensitizing properties, enabling high levels of microbial inactivation under blue light irradiation, while graphene quantum dots effectively serve as nanocarriers for hydrophobic photosensitizers, significantly improving solubility, cellular uptake, and biofilm penetration. Hybrid systems, such as N/S-doped CQDs combined with mesoporous silica or chitosan-modified carbon platforms, provide stimuli-responsive delivery and superior anti-biofilm activity. Porphyrin-encapsulated electrospun nanofibers and carbon-based nanozymes further amplify ROS generation and enable multifunctional applications, including sensing and synergistic therapies such as sonophotodynamic inactivation (SPDI). Collectively, these nanomaterials overcome key limitations of conventional aPDT by enhancing ROS production, improving biofilm disruption, and reducing required treatment parameters, while maintaining low cytotoxicity toward mammalian cells. <b>Conclusion:</b> Despite promising preclinical results, challenges remain in standardization, scalability, long-term biosafety, and clinical translation. This review highlights the transformative potential of carbon-based nanomaterials in revolutionizing aPDT and outlines future directions to accelerate their development into effective tools against resistant infections and biofilms.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51974"},"PeriodicalIF":1.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorin e6 as a Photosensitizer for Inducing Targeted Effects in Transscleral Photodynamic Therapy.","authors":"Elena Vladislavovna Samkovich, Ernest Vitalievich Boiko, Irina Evgenievna Panova, Tatyana Georgievna Grishacheva, Sergey Leonidovich Vorobyev, Elizaveta Sergeevna Kalashnikova, Alexander Anatolievich Ivanov, Sergey Borisovich Shevchenko, Viktoria Gievna Gvazava, Elizaveta Antonovna Masian","doi":"10.34172/jlms.51515","DOIUrl":"10.34172/jlms.51515","url":null,"abstract":"<p><p><b>Introduction:</b> This study aimed to evaluate the role of chlorin e6 in mediating targeted vascular injury during transscleral photodynamic therapy (TS-PDT) under controlled thermal conditions. <b>Methods:</b> Twenty eyes of ten rabbits were randomized into two groups. The TS-PDT group received intravenous chlorin e6 (2.5 mg/kg) followed by transscleral laser irradiation (660 nm, 0.17 W, 10 min.). The control group (TSLT) underwent identical laser exposure without a photosensitizer. Scleral temperature was monitored in real time using a thermal probe. On day 14, histological analysis assessed choroidal vascular thrombosis and stromal fibrosis using a semiquantitative scoring system. Retinal and scleral tissue damage was also evaluated. <b>Results:</b> The analysis accounting for inter-animal clustering revealed a significant association between chlorin e6 administration and choroidal vascular thrombosis (90% vs. 50%; adjusted OR=9.8, 95% CI: 1.4-68.9; <i>P</i>=0.021) and fibrosis (80% vs. 40%; adjusted OR=6.2, 95% CI: 1.1-35.0; <i>P</i>=0.039). Severity scores for thrombosis and fibrosis were also significantly higher in the TS-PDT group (<i>P</i><0.001 for both). No significant differences in scleral temperature (<i>P</i>≥0.45) orretinal/scleral damage were observed. <b>Conclusion:</b> Vascular damage during TS-PDT is primarily photochemical, mediated by chlorin e6. No significant intergroupdifferences were observed in monitored scleral surface temperaturesunder these parameters, arguing against a major contribution from differential surface heating. The method demonstrates short-term structuralpreservation of surrounding ocular tissues, supporting itspotential as an organ-preserving treatment for intraocular tumors.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51515"},"PeriodicalIF":1.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Light Power from 940 nm Diode Laser Transmitted Through Tooth Crown.","authors":"Mohammed Abbood Al-Maliky, Tamara Sardar Al-Karadaghi","doi":"10.34172/jlms.50816","DOIUrl":"10.34172/jlms.50816","url":null,"abstract":"<p><p><b>Introduction:</b> Light transmission in biological tissues is used in many subsurface intervention applications, such as photobiomodulation, fluorescence, and laser Doppler flowmetry. The aims of the current study were to measure the light power of a 940-nm diode laser transmitted through dental crowns and to correlate this transmission with crown thickness. <b>Methods:</b> Thirty non-carious extracted human premolar longitudinal-half-crown sections were used in this experiment. The laser device was operated in continuous wave mode at 0.59 W for 10 s. The power density was 468.25 W/cm², and the irradiation dose was 4682.5 J/cm² at the laser tip. The laser irradiation was applied twice to each sample, on the external crown surface and the pulpal surface. The transmitted laser power through the tooth crown was measured using a power meter. <b>Results:</b> Descriptive statistics indicated a transmitted power of 0.044±0.018 W when the external surface of the tooth was irradiated and 0.164±0.039 W when the pulpal side was irradiated. Spearman correlation analysis revealed a non-significant negative relationship between sample thickness and transmitted laser power in the externally irradiated group (r=- 0.111, <i>P</i>=0.558) and a significant negative relationship in the pulpal irradiated group (r=- 0.637, <i>P</i>=0.000). <b>Conclusion:</b> The laser power transmission was four times greater after irradiation of the pulpal side than the external side. Our findings demonstrated that laser transmission is inversely associated with tooth thickness.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50816"},"PeriodicalIF":1.7,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Phototherapy on Magnesium, Vitamin D, Albumin, Calcium Levels, and Platelet Counts in Neonates With Hyperbilirubinemia.","authors":"Hosein Effatpanah, Zahra Razaghi, Mohammad Javad Hossein Tehrani, Rajab Mardani, Nayebali Ahmadi","doi":"10.34172/jlms.47495","DOIUrl":"10.34172/jlms.47495","url":null,"abstract":"<p><p><b>Introduction:</b> Phototherapy is the standard treatment for neonatal hyperbilirubinemia, however, its effects on biochemical and hematological parameters remain incompletely understood. This study aimed to evaluate the impact of phototherapy on serum magnesium, vitamin D, albumin, calcium levels, and platelet counts in neonates with hyperbilirubinemia. <b>Methods:</b> A prospective before-after study was conducted on 100 neonates receiving phototherapy. Blood samples were collected before treatment and 24 hours after phototherapy. Biochemical parameters were measured using standardized assays. Albumin gene expression and protein levels were assessed using real-time PCR and Western blotting. Paired t-tests were applied to compare pre- and post-treatment values. Pearson correlation and ROC curve analyses were performed to evaluate relationships and predictive performance. <b>Results:</b> Phototherapy resulted in significant reductions in platelet counts (<i>P</i>=0.031), albumin levels (<i>P</i>=0.028), magnesium (<i>P</i>=0.004), vitamin D (<i>P</i>=0.003), and calcium levels (<i>P</i>=0.006). Magnesium demonstrated the highest diagnostic performance (AUC=0.805), followed by the magnesium/albumin ratio (AUC=0.766). A strong positive correlation was observed between magnesium and platelet counts (r=0.736, <i>P</i><0.01). Albumin mRNA expression and protein levels significantly decreased following phototherapy (<i>P</i><0.05). <b>Conclusion:</b> Phototherapy induces significant biochemical and hematological alterations in neonates, particularly affecting magnesium, albumin, calcium, vitamin D, and platelet levels. Routine monitoring of these parameters during phototherapy is recommended to prevent potential complications.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e47495"},"PeriodicalIF":1.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Proliferation and Pluripotency in Human Dental Pulp Stem Cells through 980-nm Laser Irradiation: Implications for Regenerative Dentistry.","authors":"Mohammad Hasan Soheilifar, Parnia Hemmati, Maryam Ghahremani-Nasab, Afshan Shirkavand, Hoda Keshmiri Neghab, Sima Nobari, Elahe Reyhani, Razieh Amini","doi":"10.34172/jlms.50924","DOIUrl":"10.34172/jlms.50924","url":null,"abstract":"<p><p><b>Introduction:</b> Dental pulp stem cells (DPSCs) possess remarkable proliferative ability and multilineage differentiation potential, and they are known as immunomodulatory cells. Identifying factors that enhance DPSC proliferation is crucial, as accelerated expansion is necessary for tissue engineering applications, while maintaining pluripotency gene expression is essential to preserve their proliferative and differentiation potential. Low-level laser irradiation (LLLI) has increasingly been recognized as a promising non-invasive approach to accelerate proliferation and enhance tissue regeneration. Within this framework, the current study was designed to evaluate the influence of laser irradiation on proliferation, pluripotency, and angiogenesis in DPSCs. <b>Methods:</b> The DPSCs were purchased from the Iranian Biological Resources Center and cultured under standard conditions. The experimental protocol involved exposing DPSCs to a 980 nm diode laser with an output power of 50 mW for a duration of 20 seconds, corresponding to an energy density of 1 J/cm². Following a 24-hour incubation period post-irradiation, cell viability was quantitatively measured using the MTT colorimetric assay. Subsequently, the expression levels of Sox2, Nanog, VEGF, TGF-β, PCNA, and Cyclin D1 were assessed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR), while the protein expression of Sox2, TGF-β, and Cyclin D1 was determined using western blot analysis. <b>Results:</b> The results showed that laser irradiation at 980 nm for 20 seconds increased the expression of Sox2, TGF-β, and Cyclin D1 at the RNA expression level (<i>P</i><0.05). Moreover, Sox2 and Cyclin D1 protein levels were increased compared to the control group. <b>Conclusion:</b> Our findings suggest that irradiation with a 980-nm laser at an energy density of 1 J/cm² significantly enhances the proliferative capacity and upregulates pluripotency marker expression in DPSCs, supporting its potential as a therapeutic approach in regenerative medicine.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50924"},"PeriodicalIF":1.7,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation-Assisted Vital Pulp Therapy in a Mature Permanent Tooth: A Case Report.","authors":"Vahideh Motamedosanaye, Mahboobeh Mahmood, Atefeh Sadat Langari","doi":"10.34172/jlms.50679","DOIUrl":"10.34172/jlms.50679","url":null,"abstract":"<p><p><b>Introduction:</b> Maintaining pulp vitality in mature permanent teeth with deep caries is challenging, especially when initial vitality tests are negative. <b>Case Presentation:</b> A 45-year-old male presented with extensive caries in the maxillary left lateral incisor, asymptomatic but non-responsive to cold testing, and with delayed electric response. Selective caries removal was performed without anesthesia to assess sensitivity. Photobiomodulation (PBM) using a 635-nm diode laser (100 mW, 4 J/cm²) was applied over deep dentin near the pulp with a 2-mm tip. Subsequent sessions irradiated buccal and lingual surfaces with an 8-mm tip. Pulp sensitivity returned by the fifth session, and after seven sessions, the tooth was restored with composite resin. A well-sealed adhesive restoration was placed without a liner. <b>Conclusion:</b> At 6-month follow-up, it remained vital and asymptomatic with normal radiographic findings. Diode laser PBM may restore pulp reactivity in mature teeth, supporting conservative vital pulp therapy.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50679"},"PeriodicalIF":1.7,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Inflammation and Enhancing Cell Viability: A Study on 980 nm and 660 nm Laser Irradiation in Synovial Cells.","authors":"Paria Karami, Faezeh Bozorgi, Morteza Golbashirzadeh, Jaber Zafari, Atousa Moradzadegan","doi":"10.34172/jlms.49177","DOIUrl":"10.34172/jlms.49177","url":null,"abstract":"<p><p><b>Introduction:</b> Photobiomodulation (PBM) is a non-invasive approach known to influence cellular activity and reduce inflammation. This study investigated the comparative effects of 980 nm and 660 nm PBM on human synovial cells (K4IM), focusing on cell viability and the expression of inflammatory mediators within the TRPV4/PI3K/AKT/mTOR signaling pathway. <b>Methods:</b> Human synovial cells were irradiated with 980 nm or 660 nm lasers for 30, 60, or 75 seconds using a PIoon device (continuous wave, 500 mW, 1 cm²). Cell viability was measured using the MTT assay. Gene expression levels of TRPV4, PI3K, AKT, mTOR, IL6, IL8, and IL10 were quantified via Real-Time PCR following RNA extraction and cDNA synthesis using commercial kits. Statistical analyses were performed using SPSS 22 and Excel 2021. <b>Results:</b> Both wavelengths significantly enhanced cell viability, with the strongest effect observed at 60 seconds (<i>P</i><0.001). A slight, non-significant increase occurred at 30 seconds, while 75 seconds produced a marked improvement compared to 30 seconds (<i>P</i><0.001). PBM at both wavelengths upregulated TRPV4, PI3K, AKT, mTOR, IL8, and IL10, while downregulating IL6. AKT expression was significantly elevated across all treated groups (<i>P</i><0.0001). The 660 nm wavelength demonstrated comparable efficacy to 980 nm. <b>Conclusion:</b> PBM at 660 nm and 980 nm enhances synovial cell viability and modulates inflammation through activation of the TRPV4/PI3K/AKT/mTOR pathway. These findings highlight the importance of wavelength and exposure duration in optimizing PBM therapeutic protocols.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e49177"},"PeriodicalIF":1.7,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Therapy in the Management of Endodontic-Periodontal Lesions: A Comprehensive Review of Clinical Efficacy and Therapeutic Applications.","authors":"Hassan Semyari, Ardavan Etemadi, Pouria Astaraki, Hamid Ahmadian-Moghadam, Hossein Semyari","doi":"10.34172/jlms.50692","DOIUrl":"10.34172/jlms.50692","url":null,"abstract":"<p><p><b>Introduction:</b> Endodontic-periodontal lesions (EPLs) are diagnostically and therapeutically challenging owing to dual pulpal-periodontal involvement and overlapping clinical features. Conventional management, including scaling and root planing (SRP) and standard endodontic therapy, may fail to achieve predictable outcomes due to persistent microbial contamination and the limitations of mechanical debridement. <b>Methods:</b> PubMed, Scopus, Web of Science, and Embase were searched for studies published between 1988 and 2025 on laser therapy in EPLs and related endodontic and periodontal conditions. Clinical, experimental, and review articles on diode or other laser approaches relevant to EPL were extracted and qualitatively analyzed. <b>Results:</b> Two recent randomized clinical trials and one comparative clinical study suggest that an adjunctive 940-nm diode laser may improve probing depth (PD) reduction, clinical attachment level (CAL) gain, and radiographic bone changes when added to conventional endodontic-periodontal therapy. Additional case reports, clinical series, and in vitro studies support the bactericidal effects of diode lasers in root canals and periodontal pockets, as well as enhanced decontamination through laser-activated irrigation and antimicrobial photoactivated disinfection. These studies also highlight benefits for photobiomodulation, wound healing, and pain reduction. However, the evidence base is limited by small sample sizes, heterogeneous laser parameters, variable study designs, and a lack of standardized protocols and long-term outcomes. <b>Conclusion:</b> Within the limits of the available evidence, diode lasers appear to be a promising adjunct in EPL management, with potential benefits for microbial control and tissue healing when combined with established endodontic and periodontal therapies. Further well-designed studies are required to establish standardized protocols and to confirm long-term efficacy and safety.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50692"},"PeriodicalIF":1.7,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tooth Sensitivity During In-Office Bleaching with Laser Irradiation: A Systematic Review and Meta-Analysis.","authors":"Azam Valian, Shahin Kasraei, Niusha Golbari, Sogol Nejad Karimi, Farzaneh Sadeghi Mahounak, Atiyeh Farahi","doi":"10.34172/jlms.50203","DOIUrl":"10.34172/jlms.50203","url":null,"abstract":"<p><p><b>Introduction:</b> This systematic review and meta-analysis aimed to evaluate the impact of laser irradiation during in-office bleaching on tooth sensitivity. <b>Methods:</b> A comprehensive search was conducted in PubMed, Scopus, and Web of Science for randomized controlled trials (RCTs) published up to August 2025 that assessed tooth sensitivity following laser-assisted in-office bleaching. The primary outcome was sensitivity intensity, measured using the Visual Analog Scale (VAS). A total of 230 records were retrieved, 31 full-texts were assessed, and 4 RCTs were included in the final analysis. Data were extracted, and meta-analyses were performed using a random-effects model. <b>Results:</b> Four RCTs were included. All included studies used diode lasers (wavelengths: 810-980 nm). The meta-analysis demonstrated a significant reduction in post-bleaching tooth sensitivity with laser irradiation compared to the control group (WMD=1.174; 95% CI: 0.474 to 1.874; <i>P</i>=0.001). However, high heterogeneity was observed (I²=99.93%). Sensitivity analyses confirmed the robustness of the findings, though potential publication bias was suggested. <b>Conclusion:</b> Laser irradiation during in-office bleaching appears to significantly reduce tooth sensitivity compared to conventional methods, potentially improving patient comfort. Nonetheless, the high variability among studies highlights the need for further well-designed clinical trials with standardized protocols to confirm these results and optimize laser parameters.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50203"},"PeriodicalIF":1.7,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}