Journal of lasers in medical sciences最新文献

{"title":"Nanocarrier-Assisted Laser-Driven Photodynamic/Chemo Therapy for Breast Cancer: A Narrative Review.","authors":"Sahar Abdollahi Jahdi, Parviz Parvin, Romina Khoshnevisan, Somayeh Hashamdar, Mohammad Reza Razzaghi, Mohammad Reza Masjedi","doi":"10.34172/jlms.51547","DOIUrl":"10.34172/jlms.51547","url":null,"abstract":"<p><p><b>Introduction:</b> Efficacy of conjugated photodynamic therapy (PDT)/chemotherapy in the treatment of breast cancer is summarized in this review. Alternative chemo drugs (CDs) and photosensitizers (PSs) are irradiated with lasers at various wavelengths to verify the toxicity of photo-stimulated compounds. <b>Methods:</b> The conducted studies on conjugated photodynamic and chemotherapy treatment of breast cancer across three phases (in vitro, in vivo and clinical) from 2014 to 2025 are summarized in this review. Articles on laser-activated therapies are evaluated, and irrelevant studies have been omitted. The records are sorted based on CD/PS typ laser irradiation wavelength, and energy. <b>Results:</b> Synergic PDT+chemotherapy is a promising method for breast cancer treatment according to in vitro, in vivo and clinical studies. Nevertheless, the clinical translation of the conjugated approach still meets unresolved issues, including long-term safety, limited selectivity, and biodistribution challenges. <b>Conclusion:</b> The hybrid treatment exhibits superior advantages in tumor shrinkage, high selectivity, inhibition of malignant cells, overcoming drug resistance, and metastasis control. Furthermore, the conjugate treatments mitigate the side effects of high-dosage chemotherapy.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51547"},"PeriodicalIF":1.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Low-Level and High-level Laser Therapy for Rotator Cuff-Related Shoulder Disorders: A Systematic Review and Meta-Analysis.","authors":"Sahar Dadkhahfar, Maryam Abbasian, Saba Hasanzadeh, Parsa Omidvar, Seyed Mohammadmisagh Moteshakereh, Hooshmand Zarei, Mahsa Nikkhoo, Mohammadreza Abbasian","doi":"10.34172/jlms.52056","DOIUrl":"10.34172/jlms.52056","url":null,"abstract":"<p><p><b>Introduction:</b> While photobiomodulation and high-power lasers are common for rotator cuff-related shoulder pain, evidence interpretation is hindered by inconsistent dosimetry and clinical findings. This systematic review and meta-analysis evaluate the effects of low-level (LLLT) and high-level laser therapy (HLLT) on pain, range of motion (ROM), and shoulder function. <b>Methods:</b> This PROSPERO-registered review included randomized controlled trials comparing LLLT or HLLT against sham, no treatment, or conventional care. Two reviewers independently conducted screening, data extraction, and risk-of-bias assessment. Continuous outcomes were synthesized using random-effects models, supplemented by subgroup analyses (LLLT vs. HLLT; laser vs. laser plus exercise) and sensitivity analyses to address heterogeneity. <b>Results:</b> Twenty-three trials (wavelengths 805-1064 nm) were included. Pooled analysis showed that laser therapy significantly reduced overall pain (VAS: MD -5.22; 95% CI -7.56 to -2.88; <i>P</i><0.001 <i>P</i><0.001 <i>P</i><0.001), though improvements in pain at rest, during movement, and at night were not statistically significant. After excluding outliers, modest improvements were noted in active internal rotation (MD 1.14; 95% CI 0.19-2.09; <i>P</i><0.001 <i>P</i><0.001 <i>P</i><0.001) and passive external rotation (MD -1.33; 95% CI -1.92 to -0.73; <i>P</i><0.001 <i>P</i><0.001 <i>P</i><0.001). Subgroup analysis indicated that HLLT yielded superior active-abduction outcomes compared to LLLT (<i>P</i>=0.016 <i>P</i>=0.016 <i>P</i>=0.016). Certainty was limited by heterogeneity, small sample sizes, inconsistent dosimetry, and short follow-up. <b>Conclusion:</b> Laser therapy provides modest, reproducible analgesic benefits, and selective ROM improvements, particularly when HLLT is combined with exercise. Given the limited functional gains and reporting inconsistencies, lasers should be used as an adjunct to structured rehabilitation rather than a standalone treatment. Future trials require standardized dosing and longer follow-ups.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e52056"},"PeriodicalIF":1.7,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulatory Effects of Low-Power Pulsed Laser on Oxidative Stress, Apoptosis, and Inflammatory Responses in the Testicular Tissue of Cisplatin-Treated Adult Male Mice.","authors":"Zahra Arazm, Niayesh Ebrahimdamavandi, Azar Afshar, Fakhroddin Aghajanpour, Hojjat Allah Abbaszadeh, Arefeh Fasih, Nader Momtazmanesh, Alireza Zamani, Mohsen Norouzian, Reza Soltani","doi":"10.34172/jlms.52525","DOIUrl":"10.34172/jlms.52525","url":null,"abstract":"<p><p><b>Introduction:</b> Cisplatin is widely used as a key treatment for solid tumors. Despite being a highly effective chemotherapy, the use of cisplatin is restricted by several side effects during treatment, such as germ cell depletion and testicular atrophy. Photobiomodulation (PBM) has emerged as a promising strategy for tissue repair. The present study seeks to assess the effects of PBM on improving antioxidant and anti-inflammatory responses in the testicular tissue of adult male mice subjected to cisplatin treatment. <b>Methods:</b> Twenty-four adult male NMRI mice were randomly assigned to three groups (n=8 each): an untreated Control group (Cont), an Injury group that received a solitary intraperitoneal (IP) injection of Cisplatin at 7 mg/kg (Cis), and a Treatment group that received Laser treatment at 4 J/cm² following the Cisplatin injection (Treat). Subsequently, the testes and epididymides were extracted. The right testis was designated for histological and stereological analysis, while the left testis was preserved at -80 °C for molecular and biochemical assessments. <b>Results:</b> PBM conferred notable protective effects after treatment, significantly improving the total sperm count and sperm motility in the Treat group (<i>P</i>≤0.0001). Following laser irradiation, a marked reduction in the TNF-α and IL-1β levels was observed in the Treat group (<i>P</i>=0.0008, <i>P</i>≤0.0001). Moreover, there was a significant rise in the expression of the <i>Bcl-2</i> gene in the Treat group (<i>P</i>=0.0004). <b>Conclusion:</b> Notwithstanding the constraints of the current research, this study endorses the translational potential of PBM and establishes a robust basis for forthcoming investigations in the domain of toxicology and laser-assisted therapies.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e52525"},"PeriodicalIF":1.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Toxic Keratopathy after Photorefractive Keratectomy: A Four-Year Case Report.","authors":"Raed Shatnawi, Abdallah M Aljazzazi","doi":"10.34172/jlms.50088","DOIUrl":"10.34172/jlms.50088","url":null,"abstract":"<p><p><b>Introduction:</b> Central toxic keratopathy (CTK) is an uncommon, non-inflammatory opacification of the central cornea after excimer laser refractive surgery, usually within the first postoperative week. The cornea loses central stromal tissue and flattens, and the eye becomes hyperopic. Why it happens is not known; both surgical contaminants and an immune-mediated process have been proposed. <b>Methods:</b> We describe a 26-year-old male physician who underwent bilateral photorefractive keratectomy (PRK) for refractive correction before applying for military service. <b>Results:</b> One week after surgery he had central corneal haze in both eyes, with topographic flattening and a large hyperopic astigmatic shift that was worse in the right eye. He was treated medically: the topical corticosteroid was intensified and topical cyclosporine was added. Over 16 months of follow-up the left eye recovered completely, while the right eye recovered partially and settled at an uncorrected distance visual acuity of 0.8 with faint residual paracentral haze. At four years the corneas remained stable and the visual result unchanged, without further surgical intervention. <b>Conclusion:</b> CTK is rare, but the visual loss in the first week after PRK can be severe. Recognizing it early matters, because the alternatives are an unnecessary antimicrobial course or an unnecessary operation. With close follow-up the long-term outlook is good, and patients deserve to hear about this complication before they consent to refractive surgery.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50088"},"PeriodicalIF":1.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Antibacterial Effects of Photosensitizing Silver Nanoparticles Synthesized from <i>Myrmecodia pendans</i> and Chitosan Nanoparticles against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>.","authors":"Iman Aris Fadzallah, Suryani Dyah Astuti, Sari Luthfiyah, Anindya Chandra Faizah","doi":"10.34172/jlms.51433","DOIUrl":"10.34172/jlms.51433","url":null,"abstract":"<p><p><b>Introduction:</b> Silver nanoparticles (AgNPs) exhibit potent antimicrobial activity, and their combination with chitosan nanoparticles (CsNPs) may provide enhanced antibacterial effects. Although numerous eco-friendly approaches for AgNP synthesis have been reported, the use of green-synthesized AgNPs in combination with CsNPs for laser-assisted antibacterial applications remains limited. This study aimed to develop a rapid microwave-assisted green synthesis of AgNPs using <i>Myrmecodia pendans</i> extract and to evaluate the antibacterial and photodynamic effects of AgNPs-CsNPs formulations. <b>Methods:</b> AgNPs were synthesized using <i>M. pendans</i> extract as a natural reducing and stabilizing agent rich in polyphenolic compounds. Antibacterial activity was evaluated against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> using bacterial growth assessment. Photodynamic inactivation was performed using a 405-nm blue laser with irradiation times of 90-180 s at different nanoparticle concentrations. Experiments were performed in five replicates, and data were expressed as mean±standard deviation. Statistical analysis was conducted using one-way ANOVA followed by Tukey's post hoc test. <b>Results:</b> UV-Vis spectroscopy showed characteristic absorption peaks at approximately 430 nm and 290 nm for AgNPs and CsNPs, respectively. Dynamic light scattering revealed particle sizes below 45 nm for AgNPs and approximately 11 nm for CsNPs. The combined AgNPs-CsNPs formulations demonstrated significantly greater antibacterial activity than <i>M. pendans</i> extract alone against both <i>S. aureus</i> and <i>P. aeruginosa</i> (<i>P</i><0.05). Following 405-nm blue laser irradiation for 90-180 s, the AgNPs-CsNPs formulations produced near-complete bacterial reduction, particularly against <i>P. aeruginosa</i>, whereas non-irradiated treatments exhibited lower antibacterial activity. <b>Conclusion:</b> Green-synthesized AgNPs produced using <i>M. pendans</i> extract can be effectively combined with CsNPs to enhance antibacterial activity. The combination of AgNPs-CsNPs with 405-nm blue laser irradiation showed enhanced photodynamic antibacterial performance, indicating its potential as a laser-assisted antimicrobial strategy against bacterial pathogens.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51433"},"PeriodicalIF":1.7,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Modifications of Graphene Oxide: A Practical and Reliable Choice for Enhanced Photodynamic Therapy in Cancer.","authors":"Mahfam Soleimanzadeh-Khayat, Melika Joulaei, Seyedeh Zohreh Azarshin, Elnaz Tehrani, Safoura Jabbari, Fatemeh Javani Jouni, Jaber Zafari","doi":"10.34172/jlms.51485","DOIUrl":"10.34172/jlms.51485","url":null,"abstract":"<p><p><b>Introduction:</b> Photodynamic therapy (PDT) has emerged as a minimally invasive strategy for cancer treatment because of its spatial selectivity and relatively low systemic toxicity. However, its clinical efficacy is limited by poor solubility and nonspecific distribution of photosensitizers (PSs), rapid degradation, and tumor hypoxia. Recently, graphene oxide (GO) and its derivatives have gained considerable attention as multifunctional nanocarriers capable of overcoming these limitations. <b>Methods:</b> A comprehensive literature review was conducted using recent studies focused on GO based nanoplatforms for PDT applications in cancer therapy. Relevant articles were analyzed to evaluate the physicochemical properties of GO, photosensitizer loading mechanisms, surface functionalization approaches, and therapeutic performance in different therapeutic strategies. <b>Results:</b> The reviewed studies demonstrated that GO possesses unique physicochemical characteristics enabling efficient loading of PS molecules through π-π interactions and other surface modification strategies. Functionalization approaches, including polymer coating, targeting ligands, metal nanoparticle incorporation, and stimuli responsive systems, improved PS stability, tumor targeting, and reactive oxygen species (ROS) generation. Furthermore, GO based systems showed promising performance in combined photodynamic and photothermal therapy (PDT/PTT), resulting in synergistic anticancer effects and improved therapeutic efficacy. <b>Conclusion:</b> Overall, GO based nanoplatforms represent a promising strategy for improving the therapeutic efficiency, targeting capability, and multifunctionality of PDT based cancer treatments. Nevertheless, further investigations regarding long term biosafety and clinical translation are still required.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51485"},"PeriodicalIF":1.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Platelet-Rich Fibrin (PRF) Protocol and Laser Acupuncture in the Treatment of Infertile Men with Non-Obstructive Azoospermia: A Randomized Clinical Trial.","authors":"Mohammadreza Razaghi, Reza Nicknama, Sona Zare, Mohammad Seifipoor, Mohammadmohsen Mazloumfard, Fatemeh Sheibani, Parnia Rahnamay Farnood","doi":"10.34172/jlms.52024","DOIUrl":"10.34172/jlms.52024","url":null,"abstract":"<p><p><b>Introduction:</b> Non-obstructive azoospermia (NOA) is a challenging male infertility disorder with limited treatment options. This study investigated the efficacy of novel reconstructive approaches, specifically platelet-rich fibrin (PRF), with and without laser needling, in improving testicular function and sperm retrieval in patients with NOA. <b>Methods:</b> In a randomized clinical trial, 40 men with NOA were divided into two groups: PRF + laser and PRF alone. Semen parameters (volume, concentration, motility, morphology, DNA fragmentation), hormone levels (FSH, LH, testosterone), and testicular volume were assessed at baseline, immediately post-intervention, and at one and three months. <b>Results:</b> Sperm concentration, motility, morphology, and DNA fragmentation rates showed no significant intergroup differences. While semen volume increased within groups post-intervention (<i>P</i>=0.039), this change was not significant between groups (<i>P</i>>0.05). No serious complications were reported. <b>Conclusion:</b> In summary, this study found that PRF injection, with or without laser-acupuncture, did not significantly improve sperm parameters in NOA patients in the short term. Further research with larger cohorts, extended follow-up, and precise patient selection is needed.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e52024"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of High-Intensity Laser Therapy on Pain, PPT, and ROM in Individuals with Myofascial Pain Syndrome: A Systematic Review.","authors":"Mehrdad Sadeghnia, Zinat Kalbali, Zahra Fazel, Fateme Hojjati, Mehrnaz Kajbafvala, Saeid Rezaei","doi":"10.34172/jlms.49774","DOIUrl":"10.34172/jlms.49774","url":null,"abstract":"<p><p><b>Introduction:</b> Myofascial pain syndrome (MPS) is the most common musculoskeletal pain disorder. One of the suggested treatments for MPS is High-Intensity Laser Therapy (HILT). HILT is a treatment method for addressing musculoskeletal pain and inflammation. Although many studies have demonstrated the effects of HILT, these effects are controversial due to the placebo effect of the laser. Therefore, there is a need to evaluate HILT compared to other physical therapy methods to achieve the best outcomes. This systematic review aimed to investigate the effect of HILT on pain intensity, pressure pain threshold (PPT), and joint range of motion (ROM) in subjects with MPS. <b>Methods:</b> PubMed/Medline, Scopus, Web of Science, and Science Direct were searched from inception to January 28, 2025, and the search was subsequently updated to August 2, 2025. Randomized controlled trials (RCTs) and clinical trials that assessed the effect of HILT on pain intensity, PPT, and joint ROM in subjects with MPS were included. <b>Results:</b> Twelve RCTs were included. The within-group results indicated that HILT significantly improved pain intensity, PPT, and joint ROM. However, compared to the control group, HILT had superior or similar effects on pain intensity and joint ROM. Level B evidence indicates that HILT is more effective than placebo or sham and traditional treatments in the improvement of pain and ROM in patients with trapezius trigger points. <b>Conclusion:</b> Compared to traditional treatments, HILT is more effective in reducing pain and increasing joint ROM in subjects with MPS. However, further studies comparing HILT with other treatments, especially dry needling, are needed to make a clinical decision.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e49774"},"PeriodicalIF":1.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Antimicrobial Photodynamic Therapy (aPDT) with Various Photosensitizers on the Bond Strength of Orthodontic Brackets.","authors":"Sepideh Seyfnia, Mahdjoube Goldani Moghadam, Farzaneh Ahrari","doi":"10.34172/jlms.49657","DOIUrl":"10.34172/jlms.49657","url":null,"abstract":"<p><p><b>Introduction:</b> Antimicrobial photodynamic therapy (aPDT) has demonstrated effectiveness in reducing gingival hyperplasia and preventing dental caries formation. However, concerns exist about its potential impact on the bond strength of resin composites. This study aimed to evaluate the effect of aPDT with various photosensitizers on the shear bond strength (SBS) of orthodontic brackets to enamel. <b>Methods:</b> A total of 102 healthy bovine central incisors were divided into six groups as follows: Group 1: control, Group 2: chlorhexidine (CHX), Group 3: aPDT with methylene blue and a 660-nm laser, Group 4: aPDT with indocyanine green and an 810-nm laser, Group 5: aPDT with curcumin and an LED, and Group 6: aPDT with riboflavin and an LED. Following the aPDT procedure, orthodontic brackets were bonded to the enamel surfaces. Shear bond strength was assessed using a universal testing machine, and the adhesive remnant index (ARI) scores were recorded. Data were analyzed using one-way ANOVA and Fisher's exact test, with a significance level set at <i>P</i><0.05. <b>Results:</b> The highest SBS value was found in the indocyanine green group (10.31±3.46) and the lowest in the control group (7.82±1.86). ANOVA revealed no significant difference in shear bond strength between the groups (<i>P</i>=0.337). Additionally, the ARI scores showed no significant variation across the study groups (<i>P</i>=0.882). <b>Conclusion:</b> Photodynamic therapy does not adversely affect the bond strength of orthodontic brackets to enamel, and thus it can be applied safely in orthodontic patients due to its proven antibacterial benefits.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e49657"},"PeriodicalIF":1.7,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Cost Photoacoustic Imaging System for Vascular Occlusion Detection in Polymer Phantoms.","authors":"Nesbher Vulgira, Atika Windra Sari, Mika Sillanpää, Mitrayana","doi":"10.34172/jlms.51117","DOIUrl":"10.34172/jlms.51117","url":null,"abstract":"<p><p><b>Introduction:</b> Vascular occlusion is a chronic condition that impairs blood flow to vital organs. This study developed a novel, low-cost photoacoustic imaging (PAI) system that utilizes phantom modeling to detect this condition. In this study, vascular occlusion was modeled using polyvinyl chloride-dioctyl terephthalate phantoms, which were categorized into healthy and occluded types. <b>Methods:</b> The PAI system comprised an 808-nm laser diode as the radiation source, a condenser microphone as the detector, and a mechanical stage for sample scanning. The PAI system utilized a modulated continuous-wave diode laser, operating at a frequency of 14 kHz and a 50% duty cycle. <b>Results:</b> Acoustic intensity analysis revealed that healthy vasculature consistently generated more intense signals than occluded vasculature. At a depth of 1 mm, the average intensities were 76.3 dB (healthy) and 65.2 dB (occluded), which decreased to 46.2 dB and 22.1 dB, respectively, at a 5-mm depth. Because of these differences, the contrast ratio between healthy and occluded regions ranged from 1.4 to 6.6 dB. Furthermore, the signal-to-noise ratio in healthy samples was measured at 16.1 dB (1 mm depth) and 3.2 dB (5 mm depth). <b>Conclusion:</b> This study demonstrates that a simple PAI system can distinguish between healthy and occluded vasculature.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51117"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}