Journal of lasers in medical sciences最新文献

{"title":"Combination of Different Laser Wavelengths as a Treatment Strategy for Maxillary Osteonecrosis: A Case Report.","authors":"Pilar Rocio Blanco Flórez, Jennifer Orozco Páez","doi":"10.34172/jlms.2025.18","DOIUrl":"10.34172/jlms.2025.18","url":null,"abstract":"<p><p><b>Introduction:</b> Osteonecrosis causes the death of bone tissue due to insufficient blood flow, which disrupts the supply of oxygen and nutrients, compromising the structural integrity of the bone. The jaws are particularly vulnerable due to their high bone turnover and vascularization. This study aimed to present the complex case of a patient diagnosed with maxillary osteonecrosis associated with osteomyelitis, treated exclusively with laser therapy. <b>Case Report:</b> We present the case of a 62-year-old male patient with maxillary osteonecrosis associated with osteomyelitis, manifested by an oroantral fistula located in the upper jaw. The treatment consisted of various laser therapy modalities, starting with the surgical phase on hard tissue for the excision of the necrotic bone (Er,Cr:YSGG 2780 nm laser), followed by photodynamic therapy (650 nm diode laser) for wound disinfection and intravascular laser irradiation of blood (ILIB) therapy (880 nm diode laser) in each session. <b>Conclusion:</b> The combination of different laser wavelengths was effective for the treatment of osteonecrosis.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e18"},"PeriodicalIF":1.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer and the Rise of Focal Laser Therapies: A Narrative Review of Benefits and Limitations.","authors":"Alvand Naserghandi, Amir Reza Abedi, Mohammad Amin Tofighi Zavareh, Mohammad Javad Shahsavari, Mohammad Mehdi Shadravan, Soroush Mirzaei, Mohamad Amir Kakaee, Farzad Allameh","doi":"10.34172/jlms.2025.16","DOIUrl":"10.34172/jlms.2025.16","url":null,"abstract":"<p><p><b>Introduction:</b> Prostate cancer is the second most prevalent cancer in men and remains a major global health concern. Traditional treatment modalities such as radical prostatectomy (RP) and radiation therapy, while effective, often result in significant morbidity, including urinary incontinence and sexual dysfunction. <b>Methods:</b> A narrative review was conducted to synthesize current evidence on focal laser therapy for prostate cancer. A comprehensive literature search was performed across three major databases: PubMed, Scopus, and Web of Science. The search strategy employed the following Medical Subject Headings (MeSH) terms and keywords: (\"Prostatic Neoplasms\" [MeSH] OR \"prostate cancer\") AND (\"Laser Therapy\" [MeSH] OR \"laser ablation\" OR \"focal therapy\"). The search was limited to studies published between 2000 and 2024. <b>Results:</b> The initial search retrieved 1,444 articles. After a rigorous screening of titles, abstracts, and full-texts, 79 studies met the inclusion criteria and were incorporated into the review. The selected literature enables a comprehensive and critical evaluation of the current state of research on focal laser therapy in the management of prostate cancer. <b>Conclusion:</b> While focal laser therapies offer promising outcomes with fewer side effects, their long-term efficacy and survival benefits remain uncertain. High-quality studies with long-term follow-up are essential to better define their role in the prostate cancer treatment landscape and inform optimal patient selection.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e16"},"PeriodicalIF":1.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Low-Level Laser Therapy in Controlling Inflammation and Damage-Associated Molecular Pattern Regulation in Spinal Cord Injury: A Systematic Review.","authors":"Hamid Reza Mosleh, Shahram Darabi, Hooman Kazemi Mirni, Sanaz Barisi, Zahra Mahdavirad, Hojjat-Allah Abbaszadeh, Leila Darabi","doi":"10.34172/jlms.2025.17","DOIUrl":"10.34172/jlms.2025.17","url":null,"abstract":"<p><p><b>Introduction:</b> Spinal cord injury (SCI) is a debilitating condition characterized by primary mechanical damage followed by secondary injury processes, including inflammation and gliosis. These complex pathophysiological responses significantly hinder neuronal recovery and functional restoration. Emerging therapies, such as low-level laser therapy (LLLT), offer promising avenues for mitigating these secondary effects and promoting repair. This review aims to explore the pathophysiology of SCI, with a focus on inflammation and gliosis, and to evaluate the therapeutic potential of LLLT in improving outcomes after SCI. <b>Methods:</b> A comprehensive literature search was conducted across PubMed, Scopus, Cochrane Database, Google Scholar, and Web of Science databases to identify studies published from 2000 to 2024. Keywords included \"spinal cord injury,\" \"inflammation,\" \"gliosis,\" and \"low-level laser therapy.\" Articles were screened based on relevance, and data were extracted and synthesized to provide insights into the mechanisms and therapeutic applications. <b>Results:</b> Inflammation following SCI involves a cascade of cellular and molecular events that contribute to secondary damage. Gliosis, predominantly driven by astrocytes and microglia, forms a glial scar that impedes axonal regeneration. While these processes are initially protective, their prolonged activation exacerbates neural damage. LLLT has shown the potential to modulate these responses by reducing oxidative stress, promoting anti-inflammatory pathways, and enhancing neuroprotection. Preclinical studies demonstrate that LLLT improves functional recovery, reduces gliosis, and supports axonal regeneration, although standardized protocols and clinical validation remain challenges. <b>Conclusion:</b> The interplay between inflammation and gliosis significantly influences the outcomes of SCI. LLLT emerges as a promising therapeutic strategy by targeting these processes and promoting regeneration. Further research is needed to standardize LLLT protocols and validate its efficacy in clinical settings, paving the way for improved management of SCI.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e17"},"PeriodicalIF":1.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Effects of Er,Cr:YSGG Laser, Eggshell Solution, and Their Combination on the Remineralization of Erosive Lesion Caused by Lemonade.","authors":"Fatemeh Dehghani, Roza Haghgoo, Mohammad Asnaashari, Hossein Dehghan","doi":"10.34172/jlms.2025.15","DOIUrl":"10.34172/jlms.2025.15","url":null,"abstract":"<p><p><b>Introduction:</b> Erosion is the loss of minerals by acids without the intervention of microorganisms. Complications caused by erosion make the use of therapeutic agents necessary. This study aims to survey the effects of the eggshell, the Er,Cr:YSGG laser, and their combination on the remineralization of erosive lesions caused by lemonade. <b>Methods:</b> The microhardness of 40 impacted third molar teeth was measured in this laboratory study. Then, the samples were subjected to an erosion challenge using a regular lemonade drink. After measuring microhardness, the samples were exposed to remineralizing materials: Er, Cr:YSG laser, eggshell, laser Er,Cr:YSGG, eggshell, and fluoride (positive control), and artificial saliva (negative control). Finally, data were analyzed via Kolmogorov-Smirnov, mixed-model analysis of variance (ANOVA), and LSD post hoc tests. <b>Results:</b> The microhardness of permanent third molar teeth, which was reduced after using lemonade, increased significantly after laser application compared to fluoride and artificial saliva. No significant difference was observed between the five experimental groups while there were statistically significant differences between the three stages of the study. Moreover, there was a significant interaction between the groups and stages (group * stage). The SMH of fluoride, artificial saliva, and laser+solution groups did not significantly change in the three stages of the study whilst the SMH of laser and solution groups significantly changed in the three stages. The SMH of the laser group had the most increasing trend (between erosive and treatment stages), followed by laser+solution and solution groups. However, the change in the laser+solution group was not statistically noticeable. <b>Conclusion:</b> Based on the results of this study, the Er,Cr:YSGG laser alone can be effective in the remineralization of erosive lesions caused by lemonade.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e15"},"PeriodicalIF":1.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Photobiomodulation Therapy Dosing Strategies on Strength, Clinical Outcomes, and Metabolic Responses: A Blinded Randomized Clinical Trial.","authors":"Carlos Eduardo Girasol, Luis Carlos Caseiro Filho, José Miguel Andrade Ferraz Moraes, Mateus Lelé Rinaldi, Marcelo Papoti, Rinaldo Roberto de Jesus Guirro","doi":"10.34172/jlms.2025.14","DOIUrl":"10.34172/jlms.2025.14","url":null,"abstract":"<p><p><b>Introduction:</b> Recent evidence suggests that the combination of exercise and photobiomodulation therapy (PBMT) enhances muscle performance, including improvements in strength, hypertrophy, and fatigue resistance. As muscle tissue changes after training, a dose progression over time may show additional effects. However, there needs to be more clarity regarding the optimal physical parameters for enhancing muscle performance. Thus, the aim was to evaluate the impact of strength training combined with PBMT at fixed or progressive doses on strength performance, metabolic activity, and clinical outcomes in healthy individuals. <b>Methods:</b> This was a double-blind, randomized clinical trial. Fifty-six male participants were randomly allocated into four groups: Sham, minimal dose (60 J), maximal dose (300 J), and incremental dose (60-300 J). Baseline assessments included body composition analysis and isokinetic dynamometry (peak torque and total work of the quadriceps femoris and hamstring muscles), followed by ten sessions of strength training combined with PBMT applied before each exercise session, which consisted of three sets of stiff and squats. PBMT irradiation was applied to the quadriceps and hamstrings. Training loads and psychophysiological responses were monitored throughout the intervention. Participants were reassessed at the end of the training period and followed up for a total duration of seven days. <b>Results:</b> No significant differences were observed between the groups in isokinetic strength parameters (<i>P</i>>0.05), although small to moderate effect sizes favored the Incremental and Maximal Dose groups. Similar patterns were found for psychophysiological responses and training loads across the groups. <b>Conclusion:</b> In the context of this research model, PBMT combined with strength training did not yield superior outcomes in muscle strength, psychophysiological, or metabolic parameters compared to the different dosing strategies evaluated.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e14"},"PeriodicalIF":1.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of LLLT Along With Minimally Invasive Flaps in Regeneration of Periodontal Intrabony Defects: A Randomized Controlled Clinical Trial.","authors":"Prakash Psg, Kavitha Sanjeev, Sangeetha Subramanian, Abirami Thanigaimalai, Devapriya Appukuttan","doi":"10.34172/jlms.2025.13","DOIUrl":"10.34172/jlms.2025.13","url":null,"abstract":"<p><p><b>Introduction:</b> The current study aims at evaluating the effectiveness of low level laser therapy (LLLT) in intra-bony defect regeneration by comparing the clinical parameters between periodontitis patients with intra-bony defects treated with simplified papilla preservation flap (SPPF) alone and SPPF with the adjunctive use of LLLT. <b>Methods:</b> The current study is a randomized controlled clinical trial involving 64 patients/sites, 32 sites treated with SPPF - control group and 32 sites treated with SPPF and adjunctive use of LLLT (SPPF+LLLT) - test group. Clinical parameters such as probing pocket depth (PPD), clinical attachment level (CAL), position of gingival margin (PGM), radiographic intra-bony defect depth (R-IBD), full mouth plaque score (FMPS), and full mouth bleeding score (FMBS) were evaluated at baseline, 6 months, and one year post-surgery. Radiographic defect depths were assessed at baseline and one year post-surgery. The results were statistically analyzed. <b>Results:</b> There was a statistically significant reduction in the PPD, CAL, PGM, and radiographic defect depth in the test group at the 6 months and one year post-surgery when compared with the control group (<i>P</i><0.05). In addition, the total number of sites with PPD more than 4 mm was reduced significantly in the test group when compared to the control group at 6 months and one year. <b>Conclusion:</b> The current study reports a significant improvement in PPD and radiographic intrabony defect fill in periodontitis patients treated with adjunctive LLLT supplementing SPPF. The article evaluates the adjunctive usage of LLLT in periodontal regeneration. The results reiterate the synergistic role of LLLT with periodontal surgical therapy for accelerated regenerative outcomes.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e13"},"PeriodicalIF":1.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Photobiomodulation Therapy on Ovarian Structure and GDF9, BMP15 and BMP4 Expression in the Spinal Cord Injury Female Rat Model.","authors":"Shima Jahanbaz, Hamid Reza Mosleh, Hadise Taheri, Reza Mastery Farahani, Amin Karamin, Foozhan Tahmasebinia, Hooman Kazemi Mirni, Sama Abbasi, Mahbobeh Hossainpour, Hojjat-Allah Abbaszadeh","doi":"10.34172/jlms.2025.12","DOIUrl":"10.34172/jlms.2025.12","url":null,"abstract":"<p><p><b>Introduction:</b> Spinal cord injury (SCI) often results in severe neurological deficits and secondary complications, including disruptions in female reproductive health. Current treatment options are limited in addressing both neurological recovery and reproductive outcomes. This study investigated the impact of photobiomodulation therapy (PBMT) on spinal cord healing and ovarian health in a female rat model of SCI. <b>Methods:</b> in this study 18 rats were divided into three groups (Control, contusion and PBMT) and SCI was induced by a weight drop model. Real-time PCR use for gene expression (GDF9, BMP15 and BMP4), histological analyses for ovarian tissues by hematoxylin and eosin (H&E), cell counting and ovary volume by stereology and estrogen level measured by ELISA kit. <b>Results:</b> Real-time PCR results showed that PBMT treatment significantly reduced inflammation, evidenced by lower levels of tumor necrosis factor alpha (TNF-α), and facilitated tissue repair in the ovary. Additionally, stereology results showed that ovarian assessments revealed improved follicular structure and overall enhancement of ovarian function in the PBMT-treated group compared to the contusion group, and this result is statistically significant. <b>Conclusion:</b> This research highlights the dual benefits of PBMT in supporting neurological recovery and safeguarding reproductive health in female rats following SCI. These findings point to the potential of PBMT as a novel therapeutic approach to improve outcomes for women affected by SCI.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e12"},"PeriodicalIF":1.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Clinical and Functional Outcomes Following Thulium Laser Enucleation of the Prostate in Jordan.","authors":"Samer Al-Rawashdah, Malik Ayyad, Khalil Abu Zahra, Saddam Al Demour, Mohammad Al-Zubi, Omar Ayaad","doi":"10.34172/jlms.2025.11","DOIUrl":"10.34172/jlms.2025.11","url":null,"abstract":"<p><p><b>Introduction:</b> Significantly impairs the quality of life through lower urinary tract symptoms. Ejaculation-sparing Thulium laser enucleation, a minimally invasive technique, offers symptom relief while aiming to preserve sexual function. This study aimed to assess the clinical outcomes, safety, and efficacy of thulium laser enucleation of the prostate in Jordan. <b>Methods:</b> A longitudinal, quantitative study was conducted in three private clinics and three private hospitals in Amman, Jordan. This study included 29 male patients suffering from moderate to severe benign prostatic hyperplasia (BPH). Postoperatively, at intervals of 2, 4, 6, and 8 months following ejaculation-sparing thulium laser enucleation, several instruments were utilized to measure the maximum urinary flow rate, post-void residual (PVR) volume, average flow rate, prostate-specific antigen (PSA), International Prostate Symptom Score (IPSS), and International Index of Erectile Function (IIEF-5). <b>Results:</b> After undergoing ejaculation-sparing thulium laser enucleation, the mean maximum urinary flow rate saw a significant increase from 6.3±2.8 mL/s at baseline to 19.8±3.2 mL/s at 2 months. It then increased to 20.6±3.0 mL/s at 4 months and to 19.0±1.7 mL/s at 8 months (<i>P</i><0.001). Furthermore, the average urinary flow rate improved, rising from 4.31±1.8 mL/s to 9.5±4.1 mL/s, then to 16.2±2.8 mL/s, and finally to 12.7±2.9 mL/s at the same intervals (<i>P</i><0.001). Symptom severity, as indicated by the IPSS, underwent a significant improvement from 21.33±3.1 to 5.1±3.4 (<i>P</i><0.001). <b>Conclusion:</b> Ejaculation-sparing thulium laser enucleation is an effective and safe treatment for BPH. It offers notable improvements in urinary function and symptom relief, and it also helps to preserve sexual function.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e11"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold Plasma Treatment for <i>Candida</i> Biofilm on Resin Base Dentures: A Systematic Review.","authors":"Hosein Eslami, Vahid Fakhrzadeh, Elham Nazari, Katayoun Katebi, Mohammad Alinejad","doi":"10.34172/jlms.2025.10","DOIUrl":"10.34172/jlms.2025.10","url":null,"abstract":"<p><p><b>Introduction:</b> <i>Candida</i> biofilm on resin base dentures is a common problem among denture wearers, leading to denture stomatitis and associated complications. Cold plasma treatment has been proposed as a novel and promising approach to eradicate <i>Candida</i> biofilm. This systematic review aims to evaluate the effectiveness of cold plasma treatment for <i>Candida</i> biofilm on resin base dentures. <b>Methods:</b> This systematic review study was conducted following PRISMA guidelines. The main objective was to investigate whether cold plasma treatment could reduce the number of <i>Candida</i> cells in dentures compared to other disinfection methods or controls. In September 2024, an electronic search was performed without any limitation on the publication start date in PubMed, Web of Science, Google Scholar, Embase, and Scopus databases. English in vitro studies, focusing on acrylic denture bases using cold plasma treatment as the intervention, were included. The selected articles were assessed using the QUIN risk-of-bias tool for in vitro studies conducted in dentistry. <b>Results:</b> Initially, 259 papers were identified, and 164 remained after removing duplicates. Following the screening of titles and abstracts, 21 papers remained. Ten articles were not related to dentures, and 11 studies were included. All of these articles demonstrated a medium risk of bias and were case-control in vitro studies. The evidence currently available suggests that cold plasma exhibits antimicrobial efficacy against denture candidiasis; however, its application is not without limitations. <b>Conclusion:</b> Based on the findings of in vitro studies, cold plasma shows promise as an effective tool for disinfecting dentures. Notably, significant reductions in the <i>Candida</i> cell count can be achieved within a reasonable treatment duration, although the existing data present variable results.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e10"},"PeriodicalIF":1.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed Dye, Fractional CO2, and Nd:YAG Lasers: A Comprehensive Evaluation in the Management of Nail Psoriasis.","authors":"Amirhossein Rahimnia, Amirhoushang Ehsani, Nafiseh Esmaeili, Zeinab Aryanian, Zahra Razavi, Mina Koohian Mohammadabadi, Ala Ehsani","doi":"10.34172/jlms.2025.09","DOIUrl":"10.34172/jlms.2025.09","url":null,"abstract":"<p><p><b>Introduction:</b> Nail psoriasis poses a notable challenge due to its significant impact on patient's quality of life and its resistance to traditional treatments. Recent interest has focused on laser therapies, which offer targeted treatment by addressing the underlying inflammatory processes of the disease. This study evaluated the effectiveness and safety of pulsed dye laser (PDL), fractional CO2 laser, and Nd:YAG (neodymium-doped yttrium aluminum garnet) laser for nail psoriasis. <b>Methods:</b> In this randomized clinical trial, 40 patients with mild to moderate bilateral nail psoriasis were enrolled at Razi hospital. The participants were divided into four groups: Nd:YAG laser, PDL, fractional CO2 laser, and a control group treated with calcipotriol/betamethasone ointment. Each received four treatment sessions over four months. The Nail Psoriasis Severity Index (NAPSI) was used to evaluate effectiveness, while pain and satisfaction were assessed using the visual analog scale (VAS). Statistical significance was determined, with P<0.05 as the threshold. <b>Results:</b> The study found that PDL achieved the highest reduction in NAPSI scores, with a significant 62.4% decrease, followed by a 54.6% decrease with the fractional CO2 laser. In contrast, the Nd:YAG laser achieved a less notable 32.4% improvement, while the ointment control group showed a 15.9% decrease. Pain was least reported in the PDL group, and satisfaction scores were highest among these patients. The PDL and fractional CO2 lasers outperformed both the Nd:YAG laser and the topical therapy in effectiveness and patient comfort. <b>Conclusion:</b> PDL and fractional CO2 laser treatments are superior interventions for managing nail psoriasis, providing a significant improvement in NAPSI scores and better patient experiences compared to the Nd:YAG laser and topical ointment. These findings endorse the inclusion of laser therapy in management plans for nail psoriasis, suggesting further research into optimizing their use and potential combination with other therapies. <b>Trial Registration:</b> https://irct.behdasht.gov.ir/; identifier: IRCT20220723055530N4.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"16 ","pages":"e9"},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}