Journal of lasers in medical sciences最新文献

{"title":"Low-Level Laser Therapy, Photobiomodulation, and Photodynamics with Photosensitizer Combination in Dentistry: A Systematic Review.","authors":"Lila Muntadir, Ida Bagus Narmada, Theresia Indah Budhy Sulisetyawati, Ernie Maduratna Setiawatie, Retna Apsari, Ari Triwarhani, Alexander Patera Nugraha","doi":"10.34172/jlms.49244","DOIUrl":"10.34172/jlms.49244","url":null,"abstract":"<p><p><b>Introduction:</b> Photobiomodulation (PBM), photodynamic therapy (PDT), and combined therapies have recently attracted attention due to their potentially beneficial antimicrobial, analgesic, and regenerative properties in dentistry. Although PBM and PDT have been extensively studied separately, evidence regarding their combined application is limited. This study aimed to systematically review studies employing combined PBM + PDT protocols in dental and oral applications. <b>Methods:</b> A systematic search of PubMed, ScienceDirect, ProQuest, DOAJ, and Google Scholar (2021-2025) identified original studies using combined PBM and PDT. Inclusion criteria: dental-related PBM + PDT, clear dosimetric parameters, English, primary research. Exclusion: PBM-only, PDT-only, non-dental studies, insufficient parameters Inclusion criteria: dental-related PBM and PDT; clearly reported dosimetric parameters; English language; primary research. <b>Results:</b> Eight studies met eligibility criteria. Applications included oral mucositis management, orthodontic acceleration, endodontic disinfection, oral lesion therapy, antimicrobial modulation, and regenerative endodontics. Combined PBM + PDT demonstrated enhanced antimicrobial activity, reduced inflammatory markers, accelerated wound healing, and improved patient-reported outcomes compared with single-modality treatments. <b>Conclusion:</b> PBM + PDT shows synergistic therapeutic potential across multiple dental fields. Despite promising outcomes, heterogeneity in parameters remains a limitation. Standardized protocols and high-quality clinical trials are required.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e49244"},"PeriodicalIF":1.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy and Photobiomodulation in the Treatment of Osteonecrosis: A Series of Cases.","authors":"Vanessa da Silva Pereira, Erick Ibraim Carlos da Costa, Lídia Laís de Deus Silva, Iury da Silva Ximenes, Arthur Vieira de Carvalho, Karine Cestaro Mesquita, Clarissa Pessoa Fernandes Forte, Thinali Sousa Dantas","doi":"10.34172/jlms.48814","DOIUrl":"10.34172/jlms.48814","url":null,"abstract":"<p><p><b>Introduction:</b> This study reports five cases of osteonecrosis treated with photobiomodulation and antimicrobial photodynamic therapy (aPDT). <b>Methods:</b> One patient had osteoradionecrosis, another had spontaneous osteonecrosis, and three had osteonecrosis associated with medication, all of which were smaller than 1cm, with or without bone sequestration. aPDT sessions used 0.01% methylene blue followed by 9 J of red light and photobiomodulation sessions ranging from 1 to 3 Joules of red or infrared light. In one of the cases observed, osteoplasty was necessary to reduce exposed bone height. <b>Results:</b> aPDT and photobiomodulation produced positive clinical responses, either alone or as adjuncts to minimally invasive procedures. <b>Conclusion:</b> aPDT associated with photobiomodulation, removal of necrotic bone tissue, bone reduction, and antibiotic therapy proved to be effective in treating osteonecrosis described in the five cases reported.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48814"},"PeriodicalIF":1.7,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Conventional Disinfectants: A Comparative Review of Cold Atmospheric Plasma and Photodynamic Therapy against Oral Pathogens.","authors":"Maryam Pourhajibagher, Steven Parker, Rashin Bahrami, Abbas Bahador","doi":"10.34172/jlms.51008","DOIUrl":"10.34172/jlms.51008","url":null,"abstract":"<p><p><b>Introduction:</b> Microbial resistance is a global challenge for conventional antimicrobial methods such as chlorhexidine (CHX) and sodium hypochlorite (NaOCl). Among the recently developed approaches, photodynamic therapy (PDT) and cold atmospheric plasma (CAP) have garnered attention. This study reviews the effectiveness of CAP and PDT relative to each other and to other antimicrobial methods. <b>Methods:</b> The primary keywords, including \"antimicrobial photodynamic therapy,\" \"cold plasma,\" \"disinfection,\" and \"oral pathogens,\" were used in a literature search across databases such as Google Scholar and PubMed, covering the period from January 2016 to September 2025. <b>Results:</b> CAP and PDT showed effective antimicrobial effects against oral pathogens. For CAP, main parameters include gas composition (He/O₂), power (55 W), and exposure duration (60-180 seconds). A He/O₂ plasma jet reduced the bacterial load in <i>Enterococcus faecalis</i> biofilms. The efficacy of PDT was different based on the types of photosensitizers and light parameters. Indocyanine green (0.2%) with an 810-nm laser (12 J/cm², 60 s) was effective against <i>Streptococcus mutans</i>, while Methylene blue (0.02%) with a 660-nm laser (20 J/cm², 100 s) showed higher biofilm reduction. Both methods surpassed conventional antimicrobial agents such as CHX and NaOCl, especially in biofilm penetration. <b>Conclusion:</b> CAP and PDT are promising alternatives to conventional antimicrobial methods, offering effective control of oral pathogens with lower side effects than CHX and NaOCl. However, further research is needed to optimize treatment parameters and determine the most suitable clinical applications for each method.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e51008"},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Management of a Pregnancy Tumor Using a Soft Tissue Diode Laser: A Case Report and Literature Review.","authors":"Nahid Derikvand, Seyedeh Sara Ghasemi, Hassan Piriaei","doi":"10.34172/jlms.48668","DOIUrl":"10.34172/jlms.48668","url":null,"abstract":"<p><p><b>Introduction:</b> Pregnancy tumors, also known as pyogenic granulomas or granuloma gravidarum, are benign vascular lesions commonly seen in the oral cavity of pregnant women. Though non-cancerous, they tend to grow rapidly, causing bleeding, pain, aesthetic concerns, and functional interference. Their development is linked to hormonal changes during pregnancy and local irritants like plaque or trauma. Traditional surgical removal can lead to discomfort and significant bleeding. This study aims to demonstrate a successful, minimally invasive management of a pregnancy tumor using a soft tissue diode laser, supported by a literature review highlighting this modality's benefits. <b>Methods:</b> This report presents a case involving a 27-year-old pregnant woman in her second trimester with a growing gingival lesion on the labial gingiva near the left maxillary premolars. Clinical assessment identified it as a pregnancy tumor. The lesion was excised using a 980 nm diode laser (Dr. Smile, Wiser) in continuous wave (CW) mode with a 400 μm initiated fiber, under local anesthesia. Due to effective haemostasis, sutures were unnecessary. The excised tissue was sent for histopathological analysis to confirm the diagnosis. <b>Results:</b> Laser excision was performed without intraoperative bleeding or suturing. Postoperatively, the patient experienced minimal discomfort, and healing was rapid with complete tissue regeneration by the third week. Histopathology confirmed pyogenic granuloma. The laser facilitated excellent bleeding control, minimized trauma, and enhanced patient comfort. <b>Conclusion:</b> Diode laser excision is a safe, effective, and minimally invasive treatment for pregnancy tumors. It offers significant advantages-reduced bleeding, less postoperative pain, faster healing, and higher patient satisfaction-over conventional surgical methods. The literature from 2000 to 2025 supports the reliability of diode lasers in managing oral soft tissue lesions during pregnancy.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48668"},"PeriodicalIF":1.7,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of thulium fiber laser and holmium:YAG laser for prostate enucleation: a systematic review and meta-analysis.","authors":"Phawat Luangtangvarodom, Kawintharat Harirugsakul, Manint Usawachintachit, Paweena Susantitaphong, Gantapong Sainont","doi":"10.34172/jlms.48963","DOIUrl":"10.34172/jlms.48963","url":null,"abstract":"<p><p><b>Introduction:</b> Laser enucleation has become a preferred surgical treatment for benign prostatic hyperplasia (BPH), especially for large prostates and patients unable to discontinue anticoagulation. This systematic review and meta-analysis compared the efficacy and safety of Thulium Fiber Laser Enucleation of the Prostate (ThuFLEP) and Holmium Laser Enucleation of the Prostate (HoLEP). <b>Methods:</b> We searched PubMed, Scopus, Embase, and the Cochrane Library for studies published up to February 2025. We included randomized controlled trials and observational studies comparing ThuFLEP and HoLEP in adult males with BPH. Outcomes included symptom scores (IPSS), urinary flow (Qmax), quality of life (QoL), post-void residual (PVR), enucleation time, operative time, enucleation efficiency, and complications. Risk of bias was assessed using the Cochrane RoB 2.0 tool for RCTs and the Newcastle-Ottawa Scale for cohort studies. Data were synthesized using random-effects meta-analysis models. <b>Results:</b> Eleven studies were included. IPSS, QoL, PVR, total operative time, and complications showed no significant differences between groups. HoLEP showed a significantly greater Qmax improvement at 3 months (mean difference -1.25 mL/s; 95% CI -1.847 to -0.653) and shorter enucleation time (mean difference 7.654 min; 95% CI 0.362 to 14.947), though the clinical relevance was limited. No significant differences were observed in enucleation efficiency or urinary incontinence rates. Study limitations included heterogeneity in laser settings and surgical technique, limited RCTs, and a lack of long-term follow-up. <b>Conclusion:</b> ThuFLEP and HoLEP are comparable in efficacy and safety for prostate enucleation in BPH patients. While HoLEP showed modest advantages in specific operative metrics, the clinical impact appears minimal. TFL represents a viable alternative in the surgical management of BPH.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48963"},"PeriodicalIF":1.7,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immediate, Short-Term and Long-Term Effects of Photobiomodulation on Chronic Post-Surgical Pain After Tympanomastoidectomy Surgery.","authors":"Shadman Nemati, Kamran Ezzati, Ali Faghih Habibi, Maryam Shakiba, Shadi Salamroudi, Hedieh Ramezani","doi":"10.34172/jlms.48430","DOIUrl":"10.34172/jlms.48430","url":null,"abstract":"<p><p><b>Introduction:</b> Photobiomodulation (PBM) is one of the alternatives to opioid analgesics to reduce post-operative pain. The aim of this study was to investigate the immediate, short-term, and long-term effects of PBM on chronic post-surgical pain after tympanomastoidectomy. <b>Methods:</b> A total of 138 subjects who had undergone tympanomastoidectomy were selected randomly and divided into two groups: PBM and control. Patients in the PBM group (n=64) received laser therapy (energy density of 8 j/cm2, wavelength of 980 nm, and power of 50 mW in 8 points behind the ear during ten sessions every day) with routine drug therapy, while patients in the control group (n=64) received only routine drug therapy (Dexamethasone, cephalexin 500 mg, acetaminophen 500 mg). The visual analogue scale (VAS) and the headache subscale of the neck disability index (NDI) were provided to both groups to assess pain intensity before the intervention, after sessions one and five, and at one- and three-month follow-ups. The between-group comparison was made through the Mann-Whitney U test, and the within-group comparison was performed using the Friedman test with pairwise comparisons. <b>Results:</b> No significant differences in all variables were observed between the two groups at baseline (<i>P</i>>0.05). The between-group comparison showed significantly lower VAS scores in PBM compared to the control group at all four time points of the study, resulting in a very large effect size at session 5, month 1, and month 3. Also, the PBM group had significantly lower NDI scores at session 5, month 1, and month 3 (<i>P</i><0.001). The effect size was large at session 5 and very large thereafter. <b>Conclusion:</b> The combined effects of PBM and drugs may reduce pain intensity in short-term and long-term follow-ups in patients after tympanomastoidectomy. Nevertheless, PBM did not show immediate effects on pain. <b>The trial registration number:</b> IRCT200808310011138N28.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48430"},"PeriodicalIF":1.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of using 40% HF treatment on the shear bond strength of the zirconia surface in comparison to conventional surface treatment methods.","authors":"Rahab Ghoveizi, Elaheh Beyabanaki, Sara Tavakolizadeh, Aynaz Samadnezhad, Pejman Moradi","doi":"10.34172/jlms.48130","DOIUrl":"10.34172/jlms.48130","url":null,"abstract":"<p><p><b>Introduction:</b> The goal of this investigation was to examine how various surface preparation techniques affect the Shear Bond Strength (SBS) of resin cement to zirconia restorations. <b>Methods:</b> 120 samples of zirconia ceramic disks in eight categories (10 x 3 mm) were randomly selected: 1. Control group (no surface treatments), 2. AL₂O₃ particle sandblasting, 3. 2.5 W Nd/YAG laser, 4. 3 W Nd/YAG laser, 5. Sandblasting plus 2.5 W Nd/YAG laser, 6. Sandblasting plus 3 W Nd/YAG laser, 7. 40% Hydrofluoric acid (HF), and 8. Sandblasting plus 40% HF. The analysis of one sample from each group was done using scanning. PANAVIA F2 dual-cure resin cement was then used to attach the samples to the composite resin. After thermocycling, the present researchers conducted the shear bond strength test utilizing the universal testing machine. The data were statistically evaluated using the Welch and Games-Howell tests, with a significance threshold of 0.05. <b>Results:</b> A statistically significant difference (<i>P</i><0.001) was seen between the SBS of the control and other groups. Comparison of SBS values with other groups revealed no statistically significant differences, except when compared to the control group (<i>P</i>>0.05). Sandblasting with HF acid etching had the greatest SBS, measuring 13.04 MPa. Out of all the groups, the SBS value was lowest for the control group (3.85 MPa). In terms of fracture type, the control group experienced more adhesive fractures. In the sandblasting and 3 W laser groups, the mixed and adhesive fractures were equal, and the mixed fracture was the most common type in the other groups. <b>Conclusion:</b> The greatest SBS was obtained by sandblasting combined with etching. Nevertheless, this disparity was not statistically significant. In all groups but the control group, the SBS was not statistically significant.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48130"},"PeriodicalIF":1.7,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Actimins Containing Toothpaste and Er,Cr:YSGG Laser on Remineralization of Primary Enamel Lesions.","authors":"Alireza Aghajanian, Majid Mehran, Roza Haghgoo, Mohammad Asnaashari, Mohammad-Bagher Rezvani, Fatemeh Papi","doi":"10.34172/jlms.48304","DOIUrl":"10.34172/jlms.48304","url":null,"abstract":"<p><p><b>Introduction:</b> Currently, the main focus of caries control measures is on methods for early detection and non-invasive treatment of incipient lesions. The present study aimed to compare the efficacy of a toothpaste containing Actimins and an Er,Cr:YSGG laser on the microhardness of demineralized enamel. <b>Methods:</b> Forty maxillary and mandibular primary posterior teeth with sound buccal or lingual surfaces were evaluated in this in vitro study. After measuring their baseline microhardness, the teeth were immersed in a demineralizing solution for 48 hours, and their microhardness was measured again. The teeth were then randomly divided into 5 groups of negative control (artificial saliva), positive control [1.23% acidulated phosphate fluoride (APF)], Actimins, Er,Cr:YSGG laser (0.75 W power, 20 Hz frequency, 60% water, 40% air, and 60 s pulse duration), and Actimins plus Er,Cr:YSGG laser, and underwent microhardness measurement for the third time after the intervention. The microhardness data were compared by an ANOVA and a Bonferroni test with the significance level set at 0.05. <b>Results:</b> The toothpaste containing 5% Actimins and the Er,Cr:YSGG laser significantly enhanced the remineralization of primary enamel incipient lesions. The lowest mean microhardness at baseline, after demineralization, and after remineralization was noted in the artificial saliva group. No significant difference was found in microhardness between the groups at baseline or after demineralization (<i>P</i>>0.05). <b>Conclusion:</b> According to the results, the toothpaste containing 5% Actimins and the Er,Cr:YSGG laser significantly enhanced the remineralization of primary enamel incipient lesions.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e48304"},"PeriodicalIF":1.7,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation Improves Testicular Structure and Antioxidant Defense in a Rat Model of Torsion/Detorsion.","authors":"Azar Afshar, Ali Amiri Motlagh, Reza Soltani, Hojjat Allah Abbaszadeh, Zahra Arazm, Ibrahim Mohammadzadeh, Mohsen Norozian, Fakhroddin Aghajanpour","doi":"10.34172/jlms.50905","DOIUrl":"10.34172/jlms.50905","url":null,"abstract":"<p><p><b>Introduction:</b> Testicular torsion/detorsion (T/D) causes ischemia-reperfusion injury that disrupts spermatogenesis mainly through oxidative stress. Photobiomodulation (PBM), known for its antioxidant effects, may counteract such damage. However, its efficacy in T/D injury remains unclear. This study evaluated the potential of PBM to improve sperm quality, testicular structure, and redox balance. <b>Methods:</b> Twenty-four adult male rats were randomly assigned to three groups: Sham (scrotal incision without torsion), T/D (left testis rotated 720° for 2 hours followed by detorsion), and T/D+PBM (T/D followed by transscrotal laser therapy). PBM was administered using an 810-nm diode laser at 100 mW, delivering 2 J/cm² per session for 20 seconds daily over six consecutive days. Epididymal sperm and testicular tissues were collected to assess sperm parameters, histological features, and oxidative stress markers, including superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde. <b>Results:</b> T/D reduced sperm motility, viability (<i>P</i><0.0001), and count (<i>P</i><0.05). Histological analysis revealed decreased seminiferous tubule diameter and epithelial thickness. Moreover, antioxidant enzyme activities were diminished, whereas lipid peroxidation levels increased (<i>P</i><0.001). PBM intervention improved sperm motility and viability, restored seminiferous tubule architecture, and re-established the testicular redox balance by enhancing antioxidant defense and reducing lipid peroxidation (<i>P</i><0.001). <b>Conclusion:</b> Collectively, these findings indicate that PBM effectively attenuates testicular damage induced by T/D by enhancing antioxidant defenses and restoring redox homeostasis. PBM promoted spermatogenic recovery, improved sperm quality, and preserved seminiferous tubule architecture following ischemia-reperfusion injury. These results highlight PBM as a promising, noninvasive adjunctive strategy for protecting male reproductive function after testicular ischemia insults.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50905"},"PeriodicalIF":1.7,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Photobiomodulation on Ventilatory Mechanics and Inflammatory Response in a Rat Model of Acute Lung Injury.","authors":"Rafaella Rocha Figueiredo, Gabrielly Santos Pereira, Laura Pereira Generoso, João Eduardo de Araújo, Josie Resende Torres da Silva, Marcelo Lourenço da Silva","doi":"10.34172/jlms.50021","DOIUrl":"10.34172/jlms.50021","url":null,"abstract":"<p><p><b>Introduction:</b> Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are life-threatening inflammatory conditions characterized by neutrophil recruitment, cytokine storm, and disruption of ventilatory mechanics. Despite advances in supportive care, effective pharmacological therapies remain limited. Photobiomodulation (PBM), using different light spectra, including LED and low-level laser therapy (LLLT), has shown potential anti-inflammatory and tissue-regenerative effects. However, the specific impact of PBM on acute lung inflammation is not fully established. <b>Methods:</b> This experimental study involved 288 male Wistar rats subjected to tracheal instillation of Escherichia coli lipopolysaccharide (LPS) to induce acute lung injury. Animals were allocated to control and treatment groups receiving 430 nm LED, 660 nm red laser, or 808 nm infrared laser. After 24 hours, ventilatory mechanics (resistance, viscosity, elastance, and hysteresivity) were assessed through mechanical ventilation. Lung tissue was analyzed for myeloperoxidase (MPO) activity, cytokine expression (TNF-α, IL-1β, IL-6, IL-10) by RT-qPCR, and histological alterations. <b>Results:</b> Among the phototherapies, the 660 nm red laser was the only intervention capable of significantly reducing all parameters of ventilatory mechanics, MPO activity, and inflammatory cytokines, with histological evidence of attenuated neutrophil infiltration, reduced alveolar wall thickening, and decreased pulmonary edema. The 430 nm LED attenuated only selective cytokines without histological or mechanical benefits, while the 808 nm infrared laser reduced TNF-α and IL-6 with partial histological improvement but no effect on lung mechanics. <b>Conclusion:</b> PBM with a 660 nm red laser effectively modulated the inflammatory cascade in LPS-induced ALI, reducing the cytokine storm and improving ventilatory function with histological evidence of lung protection. These findings highlight PBM as a potential adjuvant therapy for acute lung inflammation.</p>","PeriodicalId":16224,"journal":{"name":"Journal of lasers in medical sciences","volume":"17 ","pages":"e50021"},"PeriodicalIF":1.7,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}