Efficacy of Blood Products and Photobiomodulation Therapy for Neurosensory Recovery in Patients With Inferior Alveolar Nerve Injury Following Orthognathic Surgery: A Systematic Review Study.

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal of lasers in medical sciences Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI:10.34172/jlms.2025.05
Maryam Nasiri, Akram Ghannadpour, Neda Hakimiha
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引用次数: 0

Abstract

Introduction: Inferior alveolar nerve (IAN) injury is among the most common complications associated with orthognathic surgery. Managing these injuries poses significant challenges due to the lack of a standardized treatment protocol. This study aimed to systematically review the literature on the efficacy of blood products and photobiomodulation (PBM) therapy for neurosensory recovery in patients with IAN injuries after orthognathic surgery. Methods: This systematic review involved a comprehensive search of Scopus, Embase, and PubMed databases, as well as the initial 100 search results from Google Scholar, to identify relevant articles published between 2015 and 2024. The articles were selected using defined eligibility criteria. Results: The research paper reviewed 170 articles, ultimately including 14 studies that focused on IAN injury related to surgical procedures such as genioplasty, sagittal split mandibular ramus osteotomy (SSRO), and bilateral sagittal split osteotomy (BSSO). Among these studies, five assessed the effectiveness of various blood products-specifically platelet-rich fibrin (PRF), leukocyte-rich PRF (L-PRF), advanced PRF (A-PRF), and concentrated growth factor (CGF)-all of which were found to alleviate hypoesthesia. Nine studies evaluated the efficacy of PBM, primarily utilizing wavelengths of 810 and 808 nm over 5 to 10 sessions. PBM also successfully enhanced the recovery of IAN. Moreover, one article highlighted the synergistic effect of using L-PRF in conjunction with PBM. Conclusion: It appears that neurosensory recovery following IAN injury due to orthognathic surgery may be enhanced by blood-derived products such as PRF, CGF, A-PRF, and L-PRF, which release growth factors that facilitate tissue repair. Additionally, PBM further supports recovery by reducing inflammation in the initial weeks and stimulating cellular metabolism to promote regeneration in the subsequent weeks.

血液制品和光生物调节治疗对正颌手术后下肺泡神经损伤患者神经感觉恢复的疗效:一项系统回顾研究。
下牙槽神经损伤是与正颌手术相关的最常见的并发症之一。由于缺乏标准化的治疗方案,管理这些伤害带来了重大挑战。本研究旨在系统回顾有关血液制品和光生物调节(PBM)治疗对正颌手术后IAN损伤患者神经感觉恢复的疗效的文献。方法:本系统综述包括对Scopus、Embase和PubMed数据库的综合检索,以及谷歌Scholar的最初100个检索结果,以确定2015年至2024年间发表的相关文章。根据确定的合格标准选择文章。结果:本研究综述了170篇文章,最终包括14篇研究,重点关注与手术相关的IAN损伤,如颏成形术、矢状分裂下颌支截骨术(SSRO)和双侧矢状分裂截骨术(BSSO)。在这些研究中,五项研究评估了各种血液制品的有效性,特别是富血小板纤维蛋白(PRF),富白细胞PRF (L-PRF),晚期PRF (A-PRF)和浓缩生长因子(CGF),所有这些都被发现可以缓解感觉减退。9项研究评估了PBM的疗效,主要是在5到10个疗程中使用810和808 nm的波长。PBM也成功地提高了IAN的回收率。此外,一篇文章强调了将L-PRF与PBM结合使用的协同效应。结论:血源性产品如PRF、CGF、A-PRF和L-PRF可促进正颌手术所致IAN损伤后的神经感觉恢复,这些产品释放生长因子促进组织修复。此外,PBM通过在最初几周减少炎症和刺激细胞代谢来促进随后几周的再生,从而进一步支持恢复。
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来源期刊
Journal of lasers in medical sciences
Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
13.30%
发文量
24
期刊介绍: The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)
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